SIMILAR PATTERNS OF AMINO ACIDS FOR 316D_C_DVAC2_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1as4 ANTICHYMOTRYPSIN

(Homo sapiens) 		PF00079
(Serpin) 		3 THR B 377
PRO B 376
THR B 379
 None
 0.90A 316dC-1as4B:
undetectable		 316dC-1as4B:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aun PR-5D

(Nicotiana
tabacum) 		PF00314
(Thaumatin) 		3 THR A 190
PRO A 187
THR A 188
 None
 0.84A 316dC-1aunA:
undetectable		 316dC-1aunA:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.) 		PF00067
(p450) 		3 THR A 109
PRO A 107
THR A 111
 None
 0.80A 316dC-1cptA:
undetectable		 316dC-1cptA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8t HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		3 THR A 396
PRO A 392
THR A 394
 None
 0.87A 316dC-1e8tA:
undetectable		 316dC-1e8tA:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg1 ENDOGLUCANASE I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		3 THR A   5
PRO A   8
THR A   7
 None
 0.78A 316dC-1eg1A:
undetectable		 316dC-1eg1A:
4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7c ELONGATION FACTOR
1-ALPHA

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		3 THR A 240
PRO A 239
THR A 267
 None
 0.78A 316dC-1g7cA:
undetectable		 316dC-1g7cA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 THR A 428
PRO A 394
THR A 430
 None
 0.89A 316dC-1gycA:
undetectable		 316dC-1gycA:
3.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2a HYDROGENASE

(Desulfovibrio
vulgaris) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		3 THR S  80
PRO S  79
THR S 128
 None
 0.90A 316dC-1h2aS:
undetectable		 316dC-1h2aS:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3p ANTIBODY FAB
FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR H  64
PRO H  60
THR H  62
 None
 0.87A 316dC-1h3pH:
undetectable		 316dC-1h3pH:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1q ANTHRANILATE
SYNTHASE COMPONENT I

(Salmonella
enterica) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		3 THR A   7
PRO A   6
THR A 199
 None
 0.86A 316dC-1i1qA:
undetectable		 316dC-1i1qA:
2.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3e SEQA PROTEIN

(Escherichia
coli) 		PF03925
(SeqA) 		3 THR A  84
PRO A  72
THR A  70
 None
 0.80A 316dC-1j3eA:
undetectable		 316dC-1j3eA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		3 THR A  97
PRO A  95
THR A  99
 None
 0.87A 316dC-1jioA:
undetectable		 316dC-1jioA:
7.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kj0 SERINE PROTEASE
INHIBITOR I

(Schistocerca
gregaria) 		PF05375
(Pacifastin_I) 		3 THR A   5
PRO A  21
THR A  20
 None
 0.88A 316dC-1kj0A:
undetectable		 316dC-1kj0A:
38.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8j ENDOTHELIAL PROTEIN
C RECEPTOR

(Homo sapiens) 		PF16497
(MHC_I_3) 		3 THR A  48
PRO A  44
THR A  46
 None
 0.90A 316dC-1l8jA:
undetectable		 316dC-1l8jA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE

(Bos taurus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 THR A 472
PRO A 471
THR A 474
 None
 0.76A 316dC-1lamA:
undetectable		 316dC-1lamA:
2.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrr SEQA PROTEIN

(Escherichia
coli) 		PF03925
(SeqA) 		3 THR A 149
PRO A 137
THR A 135
 None
 0.86A 316dC-1lrrA:
undetectable		 316dC-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA

(Mycobacterium
tuberculosis) 		PF01625
(PMSR) 		3 THR A  63
PRO A  60
THR A  61
 None
 0.87A 316dC-1nwaA:
undetectable		 316dC-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyi HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF13242
(Hydrolase_like) 		3 THR A 245
PRO A 241
THR A 243
 None
 0.83A 316dC-1qyiA:
undetectable		 316dC-1qyiA:
2.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwe ANTIBODY 14D9

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR H  33
PRO H  52
THR H  30
 None
 0.91A 316dC-1uweH:
undetectable		 316dC-1uweH:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C) 		3 THR A1032
PRO A1034
THR A1035
 None
 0.82A 316dC-1ux6A:
undetectable		 316dC-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xru 4-DEOXY-L-THREO-5-HE
XOSULOSE-URONATE
KETOL-ISOMERASE

(Escherichia
coli) 		PF04962
(KduI) 		3 THR A 120
PRO A 123
THR A 122
 None
 0.89A 316dC-1xruA:
undetectable		 316dC-1xruA:
4.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yuz NIGERYTHRIN

(Desulfovibrio
vulgaris) 		PF02915
(Rubrerythrin) 		3 THR A 200
PRO A 175
THR A 198
 None
 0.87A 316dC-1yuzA:
undetectable		 316dC-1yuzA:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlr COAGULATION FACTOR
XI

(Homo sapiens) 		PF00089
(Trypsin) 		3 THR A  36
PRO A  37
THR A  37
 None
 0.80A 316dC-1zlrA:
undetectable		 316dC-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zn6 PHAGE-RELATED
CONSERVED
HYPOTHETICAL PROTEIN

(Bordetella
bronchiseptica) 		PF02586
(SRAP) 		3 THR A 201
PRO A 197
THR A 199
 None
 0.82A 316dC-1zn6A:
undetectable		 316dC-1zn6A:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		3 THR C  37
PRO C  36
THR C 241
 None
 0.89A 316dC-1zrtC:
undetectable		 316dC-1zrtC:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zwt MAJOR STRUCTURAL
SUBUNIT OF
BUNDLE-FORMING PILUS

(Escherichia
coli) 		PF05307
(Bundlin) 		3 THR A  99
PRO A 137
THR A 136
 None
 0.91A 316dC-1zwtA:
undetectable		 316dC-1zwtA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE

(Phanerochaete
chrysosporium) 		no annotation 3 THR A 252
PRO A 100
THR A  98
 None
 0.87A 316dC-2cl2A:
undetectable		 316dC-2cl2A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 THR A 428
PRO A 394
THR A 430
 None
 0.88A 316dC-2hzhA:
undetectable		 316dC-2hzhA:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2llf VILLIN-1

(Gallus gallus) 		PF00626
(Gelsolin) 		3 THR A  90
PRO A  86
THR A  88
 None
 0.87A 316dC-2llfA:
undetectable		 316dC-2llfA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohh TYPE A FLAVOPROTEIN
FPRA

(Methanothermobacter
thermautotrophicus) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		3 THR A 359
PRO A 322
THR A 361
 None
 0.91A 316dC-2ohhA:
undetectable		 316dC-2ohhA:
3.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osy ENDOGLYCOCERAMIDASE
II

(Rhodococcus sp.) 		PF00150
(Cellulase) 		3 THR A 441
PRO A 440
THR A 472
 None
 0.82A 316dC-2osyA:
undetectable		 316dC-2osyA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7q OUTER-MEMBRANE
LIPOPROTEIN CARRIER
PROTEIN

(Pseudomonas
aeruginosa) 		PF03548
(LolA) 		3 THR A 106
PRO A 109
THR A 108
 None
 0.87A 316dC-2w7qA:
undetectable		 316dC-2w7qA:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN

(Shewanella
oneidensis) 		PF00854
(PTR2) 		3 THR A 468
PRO A 467
THR A 470
 None
 0.81A 316dC-2xutA:
undetectable		 316dC-2xutA:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Homo sapiens) 		PF01593
(Amino_oxidase) 		3 THR A 278
PRO A 274
THR A 276
 None
FAD  A 600 ( 4.9A)
None
 0.82A 316dC-2z5xA:
undetectable		 316dC-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cue TRANSPORT PROTEIN
PARTICLE 31 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF04051
(TRAPP) 		3 THR B 217
PRO B 216
THR B 219
 None
 0.90A 316dC-3cueB:
undetectable		 316dC-3cueB:
3.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg6 ADSEVERIN

(Homo sapiens) 		PF00626
(Gelsolin) 		3 THR A 704
PRO A 700
THR A 702
 None
 0.66A 316dC-3fg6A:
undetectable		 316dC-3fg6A:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg7 VILLIN-1

(Homo sapiens) 		PF00626
(Gelsolin) 		3 THR A 708
PRO A 704
THR A 706
 None
 0.88A 316dC-3fg7A:
undetectable		 316dC-3fg7A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmt PROTEIN SEQA

(Escherichia
coli) 		PF03925
(SeqA)
PF17206
(SeqA_N) 		3 THR A 149
PRO A 137
THR A 135
 None
 0.89A 316dC-3fmtA:
undetectable		 316dC-3fmtA:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gle PILIN

(Streptococcus
pyogenes) 		PF12892
(FctA) 		3 THR A  84
PRO A  48
THR A  50
 THR  A  84 ( 0.8A)
PRO  A  48 ( 1.1A)
THR  A  50 ( 0.8A)
 0.81A 316dC-3gleA:
undetectable		 316dC-3gleA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1q ETHANOLAMINE
UTILIZATION PROTEIN
EUTJ

(Carboxydothermus
hydrogenoformans) 		PF14450
(FtsA) 		3 THR A 166
PRO A 165
THR A 147
 None
 0.89A 316dC-3h1qA:
undetectable		 316dC-3h1qA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij3 CYTOSOL
AMINOPEPTIDASE

(Coxiella
burnetii) 		PF00883
(Peptidase_M17) 		3 THR A 305
PRO A 290
THR A 307
 None
 0.75A 316dC-3ij3A:
undetectable		 316dC-3ij3A:
2.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00476
(DNA_pol_A) 		3 THR A 638
PRO A 635
THR A 636
 None
 0.71A 316dC-3ikmA:
undetectable		 316dC-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j81 US2

(Kluyveromyces
lactis) 		PF00318
(Ribosomal_S2) 		3 THR A 124
PRO A 126
THR A 147
 None
 0.79A 316dC-3j81A:
undetectable		 316dC-3j81A:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF00171
(Aldedh) 		3 THR A 124
PRO A 121
THR A 122
 None
CL  A 465 (-4.1A)
CL  A 465 (-4.1A)
 0.84A 316dC-3k9dA:
undetectable		 316dC-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krv HYDROLASE

(Geobacillus
stearothermophilus) 		PF04199
(Cyclase) 		3 THR A  48
PRO A 195
THR A  46
 None
 0.85A 316dC-3krvA:
undetectable		 316dC-3krvA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9v FAD-DEPENDENT
OXIDOREDUCTASE

(Actinomadura
kijaniata) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 THR A  51
PRO A  50
THR A  53
 None
 0.68A 316dC-3m9vA:
undetectable		 316dC-3m9vA:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my7 ALCOHOL
DEHYDROGENASE/ACETAL
DEHYDE DEHYDROGENASE

(Vibrio
parahaemolyticus) 		PF00171
(Aldedh) 		3 THR A 119
PRO A 116
THR A 117
 None
CL  A 453 ( 4.6A)
CL  A 453 ( 4.4A)
 0.87A 316dC-3my7A:
undetectable		 316dC-3my7A:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE

(Taxus
canadensis) 		PF00221
(Lyase_aromatic) 		3 THR A 129
PRO A 125
THR A 127
 None
 0.78A 316dC-3nz4A:
undetectable		 316dC-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p40 NEUROFASCIN

(Homo sapiens) 		PF13927
(Ig_3) 		3 THR A 367
PRO A 366
THR A 410
 None
 0.78A 316dC-3p40A:
undetectable		 316dC-3p40A:
2.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sc2 SERINE
CARBOXYPEPTIDASE II
(CPDW-II)

(Triticum
aestivum) 		PF00450
(Peptidase_S10) 		3 THR B 346
PRO B 342
THR B 344
 None
 0.86A 316dC-3sc2B:
undetectable		 316dC-3sc2B:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3so4 METHIONINE-ADENOSYLT
RANSFERASE

(Entamoeba
histolytica) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 THR A  49
PRO A 242
THR A  47
 None
 0.87A 316dC-3so4A:
undetectable		 316dC-3so4A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sz4 EXONUCLEASE

(Laribacter
hongkongensis) 		PF09588
(YqaJ) 		3 THR A 118
PRO A 116
THR A 120
 None
 0.80A 316dC-3sz4A:
undetectable		 316dC-3sz4A:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue3 SEPTUM FORMATION,
PENICILLIN BINDING
PROTEIN 3,
PEPTIDOGLYCAN
SYNTHETASE

(Acinetobacter
sp. ATCC 27244) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		3 THR A 360
PRO A 362
THR A 364
 None
 0.90A 316dC-3ue3A:
undetectable		 316dC-3ue3A:
2.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		3 THR A  69
PRO A  65
THR A  67
 None
 0.90A 316dC-4aioA:
undetectable		 316dC-4aioA:
1.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bil DNA MATURASE B

(Escherichia
virus T7) 		no annotation 3 THR A 261
PRO A 263
THR A 259
 None
 0.87A 316dC-4bilA:
undetectable		 316dC-4bilA:
2.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8) 		no annotation 3 THR A 297
PRO A 299
THR A 295
 None
 0.90A 316dC-4btpA:
undetectable		 316dC-4btpA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		3 THR A 647
PRO A 649
THR A 650
 None
 0.76A 316dC-4byfA:
undetectable		 316dC-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 THR A 628
PRO A 627
THR A 658
 None
 0.91A 316dC-4bziA:
undetectable		 316dC-4bziA:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Methanosarcina
mazei) 		PF01458
(UPF0051) 		3 THR A 248
PRO A 247
THR A 220
 None
 0.91A 316dC-4dn7A:
undetectable		 316dC-4dn7A:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euf PUTATIVE REDUCTASE
CA_C0462

(Clostridium
acetobutylicum) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		3 THR A 284
PRO A 286
THR A 168
 None
 0.86A 316dC-4eufA:
undetectable		 316dC-4eufA:
1.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
caccae) 		PF07523
(Big_3)
PF13306
(LRR_5) 		3 THR A 217
PRO A 192
THR A 194
 None
 0.77A 316dC-4fd0A:
undetectable		 316dC-4fd0A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdw LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF07523
(Big_3)
PF13306
(LRR_5) 		3 THR A 217
PRO A 192
THR A 194
 None
 0.74A 316dC-4fdwA:
undetectable		 316dC-4fdwA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE

(Thermothelomyces
thermophila) 		no annotation 3 THR A 210
PRO A 234
THR A 232
 None
 0.79A 316dC-4g4iA:
undetectable		 316dC-4g4iA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4j ACP-POLYENE
THIOESTERASE

(Streptomyces
globisporus) 		PF13279
(4HBT_2) 		3 THR A 128
PRO A 124
THR A 126
 None
 0.83A 316dC-4i4jA:
undetectable		 316dC-4i4jA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jru THAUMATIN-LIKE
PROTEIN

(Vitis vinifera) 		PF00314
(Thaumatin) 		3 THR A 100
PRO A 102
THR A  86
 None
 0.85A 316dC-4jruA:
undetectable		 316dC-4jruA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oie NON-STRUCTURAL
PROTEIN NS1

(West Nile virus) 		PF00948
(Flavi_NS1) 		3 THR A 230
PRO A 226
THR A 228
 None
 0.89A 316dC-4oieA:
undetectable		 316dC-4oieA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov4 2-ISOPROPYLMALATE
SYNTHASE

(Leptospira
biflexa) 		PF00682
(HMGL-like) 		3 THR A 208
PRO A 176
THR A 178
 None
KIV  A 402 (-4.2A)
KIV  A 402 (-2.8A)
 0.85A 316dC-4ov4A:
undetectable		 316dC-4ov4A:
2.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Alicyclobacillus
acidocaldarius) 		PF13416
(SBP_bac_8) 		3 THR A 259
PRO A 255
THR A 257
 None
 0.68A 316dC-4ovjA:
undetectable		 316dC-4ovjA:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3o MGS-MT1

(unidentified) 		PF07859
(Abhydrolase_3) 		3 THR A 282
PRO A 281
THR A 309
 None
 0.91A 316dC-4q3oA:
undetectable		 316dC-4q3oA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn8 VIPE

(Legionella
pneumophila) 		no annotation 3 THR A   4
PRO A   2
THR A   6
 None
 0.86A 316dC-4qn8A:
undetectable		 316dC-4qn8A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry1 PERIPLASMIC SOLUTE
BINDING PROTEIN

(Pectobacterium
atrosepticum) 		PF13416
(SBP_bac_8) 		3 THR A 301
PRO A 303
THR A 165
 None
 0.91A 316dC-4ry1A:
undetectable		 316dC-4ry1A:
3.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME

(Bacillus cereus) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		3 THR A 166
PRO A 168
THR A 162
 None
 0.90A 316dC-4s3jA:
undetectable		 316dC-4s3jA:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uu9 MEDI7814

(Homo sapiens) 		PF07686
(V-set) 		3 THR B  95
PRO B  93
THR B  94
 None
 0.89A 316dC-4uu9B:
undetectable		 316dC-4uu9B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wct FRUCTOSYL
AMINE:OXYGEN
OXIDOREDUCTASE

(Aspergillus
fumigatus) 		PF01266
(DAO) 		3 THR A 327
PRO A 329
THR A 145
 None
 0.86A 316dC-4wctA:
undetectable		 316dC-4wctA:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvh CARBOHYDRATE
ESTERASE FAMILY 2
(CE2)

(Chaetomium) 		PF13472
(Lipase_GDSL_2) 		3 THR A 285
PRO A 287
THR A 288
 None
 0.71A 316dC-4xvhA:
undetectable		 316dC-4xvhA:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw8 UBIQUITIN-LIKE
PROTEIN MDY2

(Saccharomyces
cerevisiae) 		PF16843
(Get5_bdg) 		3 THR D  23
PRO D  25
THR D  21
 None
 0.90A 316dC-5bw8D:
undetectable		 316dC-5bw8D:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwy PLASMEPSIN-2

(Plasmodium
falciparum) 		PF00026
(Asp) 		3 THR A 116
PRO A 113
THR A 114
 None
 0.81A 316dC-5bwyA:
undetectable		 316dC-5bwyA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8) 		3 THR D1946
PRO D1943
THR D1944
 None
 0.90A 316dC-5disD:
undetectable		 316dC-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eod COAGULATION FACTOR
XI

(Homo sapiens) 		PF00024
(PAN_1)
PF00089
(Trypsin) 		3 THR A 390
PRO A 392
THR A 393
 None
 0.91A 316dC-5eodA:
undetectable		 316dC-5eodA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j78 ACETALDEHYDE
DEHYDROGENASE
(ACETYLATING)

(Parageobacillus
thermoglucosidasius) 		PF00171
(Aldedh) 		3 THR A 146
PRO A 143
THR A 144
 None
ACT  A1005 (-3.9A)
ACT  A1005 (-3.3A)
 0.81A 316dC-5j78A:
undetectable		 316dC-5j78A:
2.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7z PUTATIVE SECRETED
ENDOGLYCOSYLCERAMIDA
SE

(Rhodococcus
hoagii) 		PF00150
(Cellulase) 		3 THR A 421
PRO A 420
THR A 453
 None
 0.88A 316dC-5j7zA:
undetectable		 316dC-5j7zA:
2.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfm ALDEHYDE
DEHYDROGENASE

(Rhodopseudomonas
palustris) 		PF00171
(Aldedh) 		3 THR A 203
PRO A 200
THR A 201
 None
 0.82A 316dC-5jfmA:
undetectable		 316dC-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		3 THR A 438
PRO A 264
THR A 436
 None
 0.91A 316dC-5l46A:
undetectable		 316dC-5l46A:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 2

(Sus scrofa) 		no annotation 3 THR A   6
PRO A 193
THR A   8
 None
 0.91A 316dC-5mpmA:
undetectable		 316dC-5mpmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmp ISATIN HYDROLASE

(Ralstonia
solanacearum) 		no annotation 3 THR A  77
PRO A 255
THR A  75
 None
 0.74A 316dC-5nmpA:
undetectable		 316dC-5nmpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnb ISATIN HYDROLASE A

(Labrenzia
aggregata) 		no annotation 3 THR A  72
PRO A 248
THR A  70
 None
 0.78A 316dC-5nnbA:
undetectable		 316dC-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o19 GENOME POLYPROTEIN

(Japanese
encephalitis
virus) 		no annotation 3 THR A 230
PRO A 226
THR A 228
 None
 0.90A 316dC-5o19A:
undetectable		 316dC-5o19A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o36 JAPANESE
ENCEPHALITIS VIRUS
NON-STRUCTURAL
PROTEIN 1'
(NS1'),JAPANESE
ENCEPHALITIS VIRUS
NON-STRUCTURAL
PROTEIN 1' (NS1')

(Japanese
encephalitis
virus) 		no annotation 3 THR A 230
PRO A 226
THR A 228
 None
 0.91A 316dC-5o36A:
undetectable		 316dC-5o36A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4

(Homo sapiens) 		no annotation 3 THR D 388
PRO D 385
THR D 386
 None
 0.85A 316dC-5of4D:
undetectable		 316dC-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1o GLUTATHIONE
REDUCTASE

(Vibrio
parahaemolyticus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 THR A 228
PRO A 227
THR A 197
 None
 0.91A 316dC-5u1oA:
undetectable		 316dC-5u1oA:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM6

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		3 THR 6 295
PRO 6 391
THR 6 297
 None
 0.69A 316dC-5udb6:
undetectable		 316dC-5udb6:
1.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1

(Homo sapiens) 		PF01485
(IBR) 		3 THR A 131
PRO A 127
THR A 129
 None
 0.88A 316dC-5udhA:
undetectable		 316dC-5udhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0a GLUCANASE

(Trichoderma
harzianum) 		no annotation 3 THR A   5
PRO A   8
THR A   7
 THR  A   5 ( 0.8A)
PRO  A   8 ( 1.1A)
THR  A   7 ( 0.8A)
 0.81A 316dC-5w0aA:
undetectable		 316dC-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE

(Culex
quinquefasciatus) 		PF00135
(COesterase) 		3 THR A 502
PRO A 504
THR A 505
 None
 0.82A 316dC-5w1uA:
undetectable		 316dC-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3v APOBEC3H

(Macaca
nemestrina) 		no annotation 3 THR B  43
PRO B  42
THR B  35
 None
 0.88A 316dC-5w3vB:
undetectable		 316dC-5w3vB:
2.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S) 		3 THR A 210
PRO A 209
THR A 212
 None
 0.90A 316dC-5xfaA:
undetectable		 316dC-5xfaA:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxa NON-STRUCTURAL
PROTEIN 1

(Yellow fever
virus) 		no annotation 3 THR A  60
PRO A  56
THR A  58
 None
 0.87A 316dC-5yxaA:
undetectable		 316dC-5yxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhv POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		no annotation 3 THR A 973
PRO A 956
THR A 821
 None
 0.87A 316dC-6bhvA:
undetectable		 316dC-6bhvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dll P-HYDROXYBENZOATE
HYDROXYLASE

(Pseudomonas
putida) 		no annotation 3 THR A 217
PRO A 193
THR A 192
 None
 0.84A 316dC-6dllA:
undetectable		 316dC-6dllA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 3 THR A1051
PRO A1050
THR A1086
 None
 0.89A 316dC-6eojA:
undetectable		 316dC-6eojA:
1.20