SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZZN_A_SAMA401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aow ANNEXIN IV

(Bos taurus) 		PF00191
(Annexin) 		5 LEU A 193
GLY A 157
ILE A 123
ASN A 124
ASP A  90
 None
 1.27A 2zznA-1aowA:
0.0		 2zznA-1aowA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8o ICE INHIBITOR

(Cowpox virus) 		PF00079
(Serpin) 		5 LEU A 214
GLY A 206
ILE A 204
ASN A 203
PHE A 151
 None
 1.31A 2zznA-1c8oA:
0.0		 2zznA-1c8oA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d02 TYPE II RESTRICTION
ENZYME MUNI

(Mycoplasma) 		PF11407
(RestrictionMunI) 		5 ARG A 162
PHE A 152
GLY A 154
PRO A 182
VAL A 150
 None
 1.29A 2zznA-1d02A:
undetectable		 2zznA-1d02A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fue FLAVODOXIN

(Helicobacter
pylori) 		PF00258
(Flavodoxin_1) 		5 PHE A   7
GLY A   9
ILE A   6
VAL A  48
PHE A  45
 None
 1.16A 2zznA-1fueA:
undetectable		 2zznA-1fueA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Thermotoga
maritima) 		PF01380
(SIS) 		5 PHE A  45
GLY A  47
PRO A  74
ILE A 121
PHE A  62
 None
 1.08A 2zznA-1j5xA:
2.3		 2zznA-1j5xA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis) 		PF07859
(Abhydrolase_3) 		5 ARG A 110
GLY A 150
PRO A 111
ASP A 358
VAL A 359
 None
 1.29A 2zznA-1jkmA:
1.4		 2zznA-1jkmA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		5 TYR D 115
ARG D 175
GLY D 113
ASP D 242
VAL D 239
 None
 1.23A 2zznA-1mhzD:
0.0		 2zznA-1mhzD:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oll NK RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A 102
GLY A 168
PRO A 100
VAL A  92
PHE A  13
 None
 1.18A 2zznA-1ollA:
undetectable		 2zznA-1ollA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p6f NATURAL CYTOTOXICITY
TRIGGERING RECEPTOR
1

(Homo sapiens) 		no annotation 5 LEU A 105
GLY A 171
PRO A 103
VAL A  95
PHE A  16
 None
 1.17A 2zznA-1p6fA:
undetectable		 2zznA-1p6fA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhl PROTEIN (CELL
DIVISION PROTEIN
MUKB)

(Escherichia
coli) 		PF04310
(MukB) 		5 ARG A   8
PHE A   7
GLY A   5
ILE A 183
ASN A  94
 None
 0.99A 2zznA-1qhlA:
undetectable		 2zznA-1qhlA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkx CDP-GLUCOSE-4,6-DEHY
DRATASE

(Yersinia
pseudotuberculosis) 		PF16363
(GDP_Man_Dehyd) 		5 ARG A 192
PHE A 262
GLY A 194
PRO A 231
ILE A 130
 None
None
NAD  A 360 (-3.5A)
None
NAD  A 360 (-4.8A)
 0.84A 2zznA-1rkxA:
4.4		 2zznA-1rkxA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlj INTERFERON
STIMULATED GENE
20KDA

(Homo sapiens) 		PF00929
(RNase_T) 		5 ARG A  21
ARG A  44
GLY A  24
PRO A  45
VAL A  56
 None
None
None
None
U5P  A 300 ( 4.9A)
 1.30A 2zznA-1wljA:
undetectable		 2zznA-1wljA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzn SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		5 GLY A  51
PRO A  55
ASP A  96
VAL A  97
PHE A 119
 SAH  A1001 (-3.1A)
SAH  A1001 (-4.4A)
SAH  A1001 (-3.3A)
SAH  A1001 (-3.5A)
SAH  A1001 (-4.8A)
 1.29A 2zznA-1wznA:
15.1		 2zznA-1wznA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0u HYPOTHETICAL
METHYLMALONYL-COA
DECARBOXYLASE ALPHA
SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01039
(Carboxyl_trans) 		5 PHE A 338
PRO A 289
ILE A 342
ASN A 333
VAL A 374
 None
 1.07A 2zznA-1x0uA:
undetectable		 2zznA-1x0uA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d) 		5 LEU A 137
PHE A 315
GLY A 284
ILE A 237
PHE A 114
 None
 1.14A 2zznA-2amcA:
undetectable		 2zznA-2amcA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e2n HEXOKINASE

(Sulfurisphaera
tokodaii) 		PF01869
(BcrAD_BadFG) 		5 ARG A 153
LEU A 181
ILE A 219
ASP A 218
VAL A 215
 None
 1.17A 2zznA-2e2nA:
undetectable		 2zznA-2e2nA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9h EXTRACELLULAR
ENTEROTOXIN TYPE I

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		5 LEU D  24
PHE D  65
GLY D  81
ILE D 125
VAL D 127
 None
 1.31A 2zznA-2g9hD:
undetectable		 2zznA-2g9hD:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2y FUSION PROTEIN
CONSISTS OF
IMMUNOGLOBULIN
G-BINDING PROTEIN G
AND SPLICING FACTOR,
ARGININE/SERINE-RICH
3

(Streptococcus
sp. 'group G';
Homo sapiens) 		PF00076
(RRM_1)
PF01378
(IgG_binding_B) 		5 ARG A  92
TYR A  96
PHE A  94
GLY A  98
VAL A 115
 None
 1.10A 2zznA-2i2yA:
2.3		 2zznA-2i2yA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca) 		PF04672
(Methyltransf_19) 		5 TYR A  26
GLY A  86
ILE A 111
ASP A 135
VAL A 136
 SAM  A 400 ( 3.8A)
SAM  A 400 ( 3.2A)
SAM  A 400 (-3.7A)
SAM  A 400 (-3.4A)
SAM  A 400 (-3.8A)
 0.91A 2zznA-2qe6A:
10.4		 2zznA-2qe6A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsj DNA-BINDING RESPONSE
REGULATOR, LUXR
FAMILY

(Ruegeria
pomeroyi) 		PF00072
(Response_reg) 		5 LEU A 131
GLY A 101
ILE A  82
ASP A  55
VAL A  56
 None
 1.22A 2zznA-2qsjA:
undetectable		 2zznA-2qsjA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqd PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Staphylococcus
aureus) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		5 LEU A 522
GLY A 454
ILE A 434
VAL A 395
PHE A 444
 None
 1.27A 2zznA-2wqdA:
undetectable		 2zznA-2wqdA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9x CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		5 TYR A 234
PRO A 434
ASN A 238
ASP A 241
VAL A 320
 None
None
None
None
NA  A1625 (-4.5A)
 1.29A 2zznA-2x9xA:
undetectable		 2zznA-2x9xA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9e MYOSIN-2

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 TYR X 118
PHE X 122
ILE X 685
VAL X 680
PHE X 482
 None
 1.22A 2zznA-2y9eX:
undetectable		 2zznA-2y9eX:
20.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3a27 UNCHARACTERIZED
PROTEIN MJ1557

(Methanocaldococcus
jannaschii) 		PF02475
(Met_10) 		6 ARG A  87
PHE A 104
GLY A 106
ASN A 129
ASP A 154
PHE A 178
 SAM  A 250 (-4.7A)
SAM  A 250 (-4.7A)
SAM  A 250 (-3.6A)
None
SAM  A 250 (-3.2A)
SAM  A 250 (-4.6A)
 0.86A 2zznA-3a27A:
26.4		 2zznA-3a27A:
31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ay0 UNCHARACTERIZED
PROTEIN MJ0883

(Methanocaldococcus
jannaschii) 		PF02475
(Met_10) 		11 TYR A 177
LEU A 182
ARG A 186
PHE A 203
GLY A 205
PRO A 208
ILE A 224
ASN A 225
ASP A 251
VAL A 252
PHE A 273
 ADN  A 401 (-4.3A)
None
None
ADN  A 401 (-4.9A)
ADN  A 401 ( 4.0A)
None
ADN  A 401 (-3.7A)
ADN  A 401 (-4.9A)
ADN  A 401 (-3.8A)
ADN  A 401 (-3.9A)
ADN  A 401 (-4.6A)
 0.59A 2zznA-3ay0A:
36.7		 2zznA-3ay0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf0 PROTEASE 4

(Escherichia
coli) 		PF01343
(Peptidase_S49) 		5 TYR A 420
ARG A 496
ILE A 328
VAL A 330
PHE A 529
 None
 1.29A 2zznA-3bf0A:
undetectable		 2zznA-3bf0A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ARG A 222
PHE A 191
PRO A  57
ILE A 192
VAL A 143
 None
 1.31A 2zznA-3cmtA:
undetectable		 2zznA-3cmtA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ARG A1222
PHE A1191
PRO A1057
ILE A1192
VAL A1143
 None
 1.31A 2zznA-3cmtA:
undetectable		 2zznA-3cmtA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ARG A3222
PHE A3191
PRO A3057
ILE A3192
VAL A3143
 None
 1.31A 2zznA-3cmtA:
undetectable		 2zznA-3cmtA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ARG A4222
PHE A4191
PRO A4057
ILE A4192
VAL A4143
 None
 1.31A 2zznA-3cmtA:
undetectable		 2zznA-3cmtA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ARG A 222
PHE A 191
PRO A  57
ILE A 192
VAL A 143
 None
 1.28A 2zznA-3cmuA:
undetectable		 2zznA-3cmuA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ARG A1222
PHE A1191
PRO A1057
ILE A1192
VAL A1143
 None
 1.28A 2zznA-3cmuA:
undetectable		 2zznA-3cmuA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ARG A2222
PHE A2191
PRO A2057
ILE A2192
VAL A2143
 None
 1.28A 2zznA-3cmuA:
undetectable		 2zznA-3cmuA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ARG A3222
PHE A3191
PRO A3057
ILE A3192
VAL A3143
 None
 1.28A 2zznA-3cmuA:
undetectable		 2zznA-3cmuA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ARG A4222
PHE A4191
PRO A4057
ILE A4192
VAL A4143
 None
 1.28A 2zznA-3cmuA:
undetectable		 2zznA-3cmuA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ARG A5222
PHE A5191
PRO A5057
ILE A5192
VAL A5143
 None
 1.28A 2zznA-3cmuA:
undetectable		 2zznA-3cmuA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ARG A1222
PHE A1191
PRO A1057
ILE A1192
VAL A1143
 None
 1.17A 2zznA-3cmvA:
undetectable		 2zznA-3cmvA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehk PRUNIN

(Prunus dulcis) 		PF00190
(Cupin_1) 		5 TYR A 402
PHE A 466
GLY A 405
ASN A 404
VAL A 428
 None
 1.19A 2zznA-3ehkA:
undetectable		 2zznA-3ehkA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fku NEUTRALIZING
ANTIBODY F10

(Homo sapiens) 		no annotation 5 LEU X  83
GLY X  49
ASN X  59
ASP X 232
VAL X 239
 None
 1.29A 2zznA-3fkuX:
undetectable		 2zznA-3fkuX:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		PF00632
(HECT) 		5 LEU A4249
PHE A4299
GLY A4302
ASN A4343
ASP A4346
 None
None
NA  A5001 ( 4.9A)
NA  A5001 (-3.2A)
None
 1.28A 2zznA-3g1nA:
undetectable		 2zznA-3g1nA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6r PUTATIVE TRANSFERASE
PH0793

(Pyrococcus
horikoshii) 		PF02475
(Met_10) 		5 ARG A 116
PHE A 133
GLY A 135
ASP A 183
PHE A 207
 None
 0.76A 2zznA-3k6rA:
26.7		 2zznA-3k6rA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Ruegeria
pomeroyi) 		PF00356
(LacI)
PF00532
(Peripla_BP_1) 		5 ARG A 300
LEU A  76
PRO A  74
ILE A 165
VAL A 163
 None
 1.24A 2zznA-3kjxA:
undetectable		 2zznA-3kjxA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcc PUTATIVE METHYL
CHLORIDE TRANSFERASE

(Arabidopsis
thaliana) 		PF05724
(TPMT) 		5 PHE A 141
GLY A  76
ILE A  96
ASP A 123
VAL A 124
 SAH  A 300 (-4.6A)
SAH  A 300 (-3.5A)
SAH  A 300 (-4.2A)
SAH  A 300 (-3.8A)
SAH  A 300 (-4.1A)
 0.76A 2zznA-3lccA:
14.9		 2zznA-3lccA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mae 2-OXOISOVALERATE
DEHYDROGENASE E2
COMPONENT,
DIHYDROLIPOAMIDE
ACETYLTRANSFERASE

(Listeria
monocytogenes) 		PF00198
(2-oxoacid_dh) 		5 PHE A 331
GLY A 329
ILE A 277
VAL A 252
PHE A 397
 None
 1.30A 2zznA-3maeA:
undetectable		 2zznA-3maeA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mae 2-OXOISOVALERATE
DEHYDROGENASE E2
COMPONENT,
DIHYDROLIPOAMIDE
ACETYLTRANSFERASE

(Listeria
monocytogenes) 		PF00198
(2-oxoacid_dh) 		5 PHE A 331
ILE A 277
ASN A 278
VAL A 252
PHE A 397
 None
 1.22A 2zznA-3maeA:
undetectable		 2zznA-3maeA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nip 3-GUANIDINOPROPIONAS
E

(Pseudomonas
aeruginosa) 		PF00491
(Arginase) 		5 LEU A   9
PHE A  23
GLY A  86
ILE A  40
VAL A 122
 None
 1.29A 2zznA-3nipA:
2.7		 2zznA-3nipA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3out GLUTAMATE RACEMASE

(Francisella
tularensis) 		PF01177
(Asp_Glu_race) 		5 LEU A  17
PHE A  10
GLY A   8
ILE A  63
VAL A  85
 None
 1.22A 2zznA-3outA:
2.1		 2zznA-3outA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owa ACYL-COA
DEHYDROGENASE

(Bacillus
anthracis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ARG A 509
TYR A 323
LEU A  97
GLY A 327
ASP A  22
 None
 1.15A 2zznA-3owaA:
undetectable		 2zznA-3owaA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		5 ARG A 254
LEU A 735
PHE A 221
PRO A  27
ILE A 210
 None
 1.20A 2zznA-3pieA:
3.0		 2zznA-3pieA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ARG A 179
GLY A 192
PRO A 194
ASP A 364
VAL A 372
 None
 1.31A 2zznA-3ppsA:
undetectable		 2zznA-3ppsA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfh EPIDERMIN LEADER
PEPTIDE PROCESSING
SERINE PROTEASE EPIP

(Staphylococcus
aureus) 		PF00082
(Peptidase_S8) 		5 ARG A 214
PHE A 216
GLY A 188
ILE A 139
VAL A 245
 None
 1.29A 2zznA-3qfhA:
3.0		 2zznA-3qfhA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qiv SHORT-CHAIN
DEHYDROGENASE OR
3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		5 GLY A  14
ILE A  37
ASN A  38
ASP A  62
VAL A  63
 None
 0.92A 2zznA-3qivA:
7.1		 2zznA-3qivA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpk BACKBONE PILUS
SUBUNIT

(Streptococcus
pneumoniae) 		PF16555
(GramPos_pilinD1)
PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		5 TYR A 234
PRO A 434
ASN A 238
ASP A 241
VAL A 320
 None
 1.23A 2zznA-3rpkA:
undetectable		 2zznA-3rpkA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		5 TYR A2253
LEU A1949
PHE A1992
ILE A1960
PHE A2080
 None
 1.26A 2zznA-4asiA:
undetectable		 2zznA-4asiA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayg GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		5 ARG A1308
GLY A1277
ASN A1253
ASP A1246
VAL A1294
 None
 1.03A 2zznA-4aygA:
undetectable		 2zznA-4aygA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		5 LEU C  82
ARG C  87
GLY C1043
ILE C1039
VAL C1037
 None
 1.24A 2zznA-4hb4C:
undetectable		 2zznA-4hb4C:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxd RNA-DIRECTED RNA
POLYMERASE L

(Dugbe
orthonairovirus) 		PF02338
(OTU) 		5 TYR B  28
PRO B  21
ASN B 143
ASP B 153
VAL B 147
 None
 1.15A 2zznA-4hxdB:
undetectable		 2zznA-4hxdB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6v AMIDOHYDROLASE 2

(Planctopirus
limnophila) 		PF02614
(UxaC) 		5 ARG A 420
GLY A 370
ILE A 426
ASN A 422
PHE A 141
 None
 1.16A 2zznA-4i6vA:
undetectable		 2zznA-4i6vA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuy SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE

(Acinetobacter
baumannii) 		PF00106
(adh_short) 		5 TYR A  56
PHE A  28
GLY A  32
ASN A  34
VAL A  89
 None
 1.30A 2zznA-4iuyA:
6.7		 2zznA-4iuyA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jon CENTROSOMAL PROTEIN
OF 170 KDA

(Homo sapiens) 		PF00498
(FHA) 		5 ARG A  88
PHE A  89
GLY A  65
ASN A  64
VAL A  25
 None
 1.28A 2zznA-4jonA:
undetectable		 2zznA-4jonA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnv THIOESTER-CONTAINING
PROTEIN I

(Anopheles
gambiae) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 ARG A 141
LEU A 672
GLY A 181
PRO A 151
VAL A 160
 None
 1.29A 2zznA-4lnvA:
undetectable		 2zznA-4lnvA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8n RAS-RELATED PROTEIN
RAP-1B

(Homo sapiens) 		PF00071
(Ras) 		5 TYR E   4
PHE E 158
GLY E  77
PRO E 110
ASP E  57
 None
None
None
None
MG  E 200 (-3.5A)
 1.31A 2zznA-4m8nE:
undetectable		 2zznA-4m8nE:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk6 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		5 TYR A 291
PHE A 293
GLY A 315
VAL A 303
PHE A 301
 None
None
None
MLY  A 304 ( 3.2A)
None
 1.20A 2zznA-4nk6A:
undetectable		 2zznA-4nk6A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovb PROTEIN OSA

(Shigella
flexneri) 		no annotation 5 TYR A  68
GLY A 170
ASN A  70
VAL A 132
PHE A 134
 AUC  A 206 (-3.2A)
None
None
None
None
 1.24A 2zznA-4ovbA:
undetectable		 2zznA-4ovbA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4owt INTEGRATOR COMPLEX
SUBUNIT 3
SOSS COMPLEX SUBUNIT
C

(Homo sapiens;
Homo sapiens) 		PF10189
(Ints3)
PF15925
(SOSSC) 		5 ARG A 263
TYR C  82
LEU C 101
ASN A 260
VAL A 233
 None
 1.07A 2zznA-4owtA:
undetectable		 2zznA-4owtA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozy POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		5 TYR A 291
PHE A 293
GLY A 315
VAL A 303
PHE A 301
 None
 1.14A 2zznA-4ozyA:
undetectable		 2zznA-4ozyA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D

(Vibrio
cholerae;
Vibrio cholerae) 		PF03116
(NQR2_RnfD_RnfE)
PF02508
(Rnf-Nqr) 		5 LEU B 174
PHE B 185
ASN B 203
VAL B 189
PHE D 189
 None
 1.22A 2zznA-4p6vB:
undetectable		 2zznA-4p6vB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlp ALANINE AND PROLINE
RICH PROTEIN,
TUBERCULOSIS
NECROTIZING TOXIN
(TNT)

(Mycobacterium
tuberculosis) 		PF14021
(TNT) 		5 ARG B 713
GLY B 813
ASN B 726
VAL B 784
PHE B 696
 None
 1.25A 2zznA-4qlpB:
undetectable		 2zznA-4qlpB:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlp ALANINE AND PROLINE
RICH PROTEIN,
TUBERCULOSIS
NECROTIZING TOXIN
(TNT)

(Mycobacterium
tuberculosis) 		PF14021
(TNT) 		5 ARG B 713
PRO B 812
ASN B 726
VAL B 784
PHE B 696
 None
 1.21A 2zznA-4qlpB:
undetectable		 2zznA-4qlpB:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0c ABGT PUTATIVE
TRANSPORTER FAMILY

(Alcanivorax
borkumensis) 		PF03806
(ABG_transport) 		5 PHE A 382
GLY A 428
ILE A 389
ASN A 390
PHE A 407
 None
None
None
NA  A 801 (-2.9A)
None
 1.27A 2zznA-4r0cA:
undetectable		 2zznA-4r0cA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		5 LEU A 477
ARG A  15
GLY A 432
ILE A 315
VAL A 373
 None
 1.20A 2zznA-4re2A:
undetectable		 2zznA-4re2A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v36 LYSYL-TRNA-DEPENDENT
L-YSYL-PHOSPHATIDYLG
YCEROL SYNTHASE

(Bacillus
licheniformis) 		PF09924
(DUF2156) 		5 TYR A 559
LEU A 534
GLY A 526
VAL A 607
PHE A 609
 None
 1.29A 2zznA-4v36A:
undetectable		 2zznA-4v36A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB

(Drosophila
melanogaster) 		PF10613
(Lig_chan-Glu_bd) 		5 GLY A  18
PRO A  20
ASN A 180
ASP A  65
VAL A  63
 None
 1.30A 2zznA-4wxjA:
undetectable		 2zznA-4wxjA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zch TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B

(Homo sapiens) 		PF00229
(TNF) 		5 LEU A  56
PHE A 201
GLY A 288
ASP A 265
VAL A 195
 None
 1.28A 2zznA-4zchA:
undetectable		 2zznA-4zchA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		5 PRO A 132
ILE A 225
ASN A 176
VAL A 216
PHE A 180
 None
 1.15A 2zznA-5d0fA:
undetectable		 2zznA-5d0fA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgq PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN

(Photobacterium
profundum) 		PF00759
(Glyco_hydro_9) 		5 TYR A 564
LEU A 489
GLY A 521
ILE A 558
ASP A 139
 None
 1.27A 2zznA-5dgqA:
undetectable		 2zznA-5dgqA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e72 N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE

(Thermococcus
kodakarensis) 		PF01170
(UPF0020)
PF02926
(THUMP) 		5 LEU A 165
PHE A 187
GLY A 189
ILE A 209
ASP A 235
 None
SAM  A 400 (-4.7A)
SAM  A 400 (-3.3A)
SAM  A 400 (-3.9A)
SAM  A 400 (-3.4A)
 0.88A 2zznA-5e72A:
16.6		 2zznA-5e72A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fod LEUCYL-TRNA
SYNTHETASE

(Plasmodium
falciparum) 		no annotation 5 PHE A 391
GLY A 393
ILE A 390
VAL A 283
PHE A 289
 None
 1.24A 2zznA-5fodA:
undetectable		 2zznA-5fodA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghe PESTICIDAL CRYSTAL
PROTEIN CRY6AA

(Bacillus
thuringiensis) 		no annotation 5 PHE A 186
GLY A 189
ILE A 200
ASN A 199
ASP A  90
 None
 1.12A 2zznA-5gheA:
undetectable		 2zznA-5gheA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5has SEC7

(Thielavia
terrestris) 		PF12783
(Sec7_N)
PF16213
(DCB) 		5 LEU A 169
PHE A 177
ILE A 355
ASN A 352
VAL A 357
 None
 1.12A 2zznA-5hasA:
undetectable		 2zznA-5hasA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i70 PLASMEPSIN IV

(Plasmodium
falciparum) 		no annotation 5 LEU B 143
GLY B 125
ILE B 103
ASN B  39
VAL B  42
 None
 1.31A 2zznA-5i70B:
undetectable		 2zznA-5i70B:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icq METHYLOCYSTIS PARVUS
OBBP MBNE

(Methylocystis
parvus) 		PF00496
(SBP_bac_5) 		5 ARG A 339
PHE A 342
PRO A 406
VAL A 471
PHE A 444
 None
 1.30A 2zznA-5icqA:
undetectable		 2zznA-5icqA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8j HISTONE DEACETYLASE
HDA1

(Saccharomyces
cerevisiae) 		PF09757
(Arb2) 		5 LEU A 469
PHE A 537
GLY A 541
ILE A 695
PHE A 621
 None
 1.20A 2zznA-5j8jA:
undetectable		 2zznA-5j8jA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcn OS09G0567300 PROTEIN

(Oryza sativa) 		PF07992
(Pyr_redox_2) 		5 TYR A 174
LEU A 203
GLY A 172
VAL A 221
PHE A 353
 NAD  A 501 (-3.6A)
None
NAD  A 501 ( 4.5A)
None
None
 1.20A 2zznA-5jcnA:
2.2		 2zznA-5jcnA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp0 BETA-GLUCOSIDASE
BOGH3B

(Bacteroides
ovatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ARG A 549
LEU A 539
ARG A 570
GLY A 528
VAL A 584
 None
 1.23A 2zznA-5jp0A:
undetectable		 2zznA-5jp0A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy1 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Paraburkholderia
xenovorans) 		PF13561
(adh_short_C2) 		5 GLY A  15
ILE A  38
ASN A  39
ASP A  63
VAL A  64
 NAD  A 301 ( 4.2A)
NAD  A 301 (-3.7A)
None
NAD  A 301 (-3.8A)
NAD  A 301 (-3.6A)
 0.98A 2zznA-5jy1A:
6.9		 2zznA-5jy1A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		5 LEU A 242
PHE A 309
GLY A 319
ILE A 312
PHE A 270
 None
None
None
CU  A 808 ( 4.9A)
None
 1.12A 2zznA-5k8dA:
undetectable		 2zznA-5k8dA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA

(Bacillus
thuringiensis) 		no annotation 5 PHE A 186
GLY A 189
ILE A 200
ASN A 199
ASP A  90
 None
 0.96A 2zznA-5kucA:
undetectable		 2zznA-5kucA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF03971
(IDH) 		5 ARG A 731
LEU A 694
GLY A 661
ASN A 659
VAL A 708
 None
 1.13A 2zznA-5kvuA:
undetectable		 2zznA-5kvuA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxi NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4

(Homo sapiens) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 ARG A 171
ILE A  48
ASN A  60
ASP A  49
VAL A  50
 None
 0.91A 2zznA-5kxiA:
undetectable		 2zznA-5kxiA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		no annotation 5 LEU B4249
PHE B4299
GLY B4302
ASN B4343
ASP B4346
 None
 1.27A 2zznA-5lp8B:
undetectable		 2zznA-5lp8B:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m11 IMMUNOREACTIVE 84KD
ANTIGEN PG93

(Porphyromonas
gingivalis) 		no annotation 5 ARG A 424
LEU A 457
ASN A 389
VAL A 362
PHE A 416
 None
 1.07A 2zznA-5m11A:
undetectable		 2zznA-5m11A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 5 ARG W 563
GLY W 397
ILE W 540
ASP W 513
VAL W 512
 None
None
None
ADP  W1501 ( 4.0A)
None
 1.22A 2zznA-5o9gW:
2.2		 2zznA-5o9gW:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubu PUTATIVE
ACETAMIDASE/FORMAMID
ASE

(Yersinia
enterocolitica) 		PF03069
(FmdA_AmdA) 		5 GLY A 197
PRO A 165
ILE A 201
ASN A 257
VAL A 101
 None
 1.29A 2zznA-5ubuA:
undetectable		 2zznA-5ubuA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		5 ARG A 188
PHE A 234
ILE A 249
VAL A 236
PHE A 342
 None
 0.97A 2zznA-5vocA:
undetectable		 2zznA-5vocA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A

(Pyrococcus
abyssi) 		no annotation 9 ARG A 133
ARG A 174
PHE A 191
GLY A 193
PRO A 196
ILE A 214
ASN A 215
ASP A 243
VAL A 244
 G  C  37 ( 4.0A)
None
MTA  A 401 (-4.4A)
MTA  A 401 (-3.6A)
None
MTA  A 401 (-3.7A)
None
MTA  A 401 (-3.3A)
MTA  A 401 (-3.8A)
 0.66A 2zznA-5wt3A:
28.1		 2zznA-5wt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM

(Homo sapiens) 		no annotation 5 ARG A 577
TYR A 392
ASN A 575
ASP A 608
PHE A 486
 None
 1.13A 2zznA-5xgjA:
undetectable		 2zznA-5xgjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyf TERF1-INTERACTING
NUCLEAR FACTOR 2

(Homo sapiens) 		no annotation 5 LEU A  41
PHE A  14
GLY A   8
ASP A 172
VAL A 173
 None
 1.28A 2zznA-5xyfA:
undetectable		 2zznA-5xyfA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B

(Pyrococcus
abyssi) 		PF02475
(Met_10) 		9 TYR A 164
LEU A 169
ARG A 173
PHE A 190
GLY A 192
PRO A 195
ASN A 213
ASP A 238
PHE A 260
 None
 0.68A 2zznA-5yacA:
24.4		 2zznA-5yacA:
42.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjq -

(-) 		no annotation 5 TYR A 404
ARG A 311
PHE A 302
GLY A 306
VAL A 299
 None
 1.25A 2zznA-6cjqA:
undetectable		 2zznA-6cjqA:
undetectable