SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZZM_A_SAMA401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3b PROTEIN (GLUTAMATE
DEHYDROGENASE)


(Thermotoga
maritima)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
3 ARG A 190
ASP A 362
ASN A 368
None
0.85A 2zzmA-1b3bA:
4.4
2zzmA-1b3bA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE


(Pseudomonas
fluorescens)
PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5)
3 ARG A  83
ASP A 138
ASN A  55
None
0.86A 2zzmA-1cjxA:
undetectable
2zzmA-1cjxA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e32 P97

(Mus musculus)
PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
3 ARG A  95
ASP A 204
ASN A  90
None
0.79A 2zzmA-1e32A:
undetectable
2zzmA-1e32A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH


(Escherichia
coli)
PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind)
3 ARG A 162
ASP A 101
ASN A 156
None
0.84A 2zzmA-1gz0A:
undetectable
2zzmA-1gz0A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE


(Schizosaccharomyces
pombe)
PF03372
(Exo_endo_phos)
3 ARG A 744
ASP A 713
ASN A 706
2IP  A 302 (-2.8A)
None
None
0.58A 2zzmA-1i9zA:
1.8
2zzmA-1i9zA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5o CPI-17

(Sus scrofa)
PF05361
(PP1_inhibitor)
3 ARG A  25
ASP A  17
ASN A  72
None
0.89A 2zzmA-1k5oA:
undetectable
2zzmA-1k5oA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lar PROTEIN (LAR)

(Homo sapiens)
PF00102
(Y_phosphatase)
3 ARG A1365
ASP A1407
ASN A1349
None
0.79A 2zzmA-1larA:
undetectable
2zzmA-1larA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)


(Limulus
polyphemus)
PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C)
3 ARG A 215
ASP A 357
ASN A 362
None
0.64A 2zzmA-1llaA:
undetectable
2zzmA-1llaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE


(Methanothermobacter
marburgensis)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
3 ARG A 526
ASP A  78
ASN A 341
None
0.85A 2zzmA-1mroA:
undetectable
2zzmA-1mroA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)


(Escherichia
coli)
PF00199
(Catalase)
PF06628
(Catalase-rel)
3 ARG A 278
ASP A 352
ASN A 404
None
0.85A 2zzmA-1qf7A:
undetectable
2zzmA-1qf7A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjm LACTOFERRIN

(Equus caballus)
PF00405
(Transferrin)
3 ARG A 531
ASP A 563
ASN A 556
None
0.89A 2zzmA-1qjmA:
undetectable
2zzmA-1qjmA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpm RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
MU


(Homo sapiens)
PF00102
(Y_phosphatase)
3 ARG A 939
ASP A 981
ASN A 923
None
0.88A 2zzmA-1rpmA:
undetectable
2zzmA-1rpmA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1v SH3 DOMAIN-BINDING
GLUTAMIC ACID-RICH
PROTEIN-LIKE 3


(Mus musculus)
PF04908
(SH3BGR)
3 ARG A  51
ASP A  39
ASN A  44
None
0.87A 2zzmA-1t1vA:
undetectable
2zzmA-1t1vA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te2 2-DEOXYGLUCOSE-6-P
PHOSPHATASE


(Escherichia
coli)
PF13419
(HAD_2)
3 ARG A 201
ASP A 173
ASN A 176
None
CA  A 702 (-2.9A)
None
0.67A 2zzmA-1te2A:
2.1
2zzmA-1te2A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1


(Rattus
norvegicus)
PF00996
(GDI)
3 ARG A  40
ASP A 433
ASN A  46
None
0.60A 2zzmA-1vg0A:
undetectable
2zzmA-1vg0A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1n 4-ALPHA-GLUCANOTRANS
FERASE


(Solanum
tuberosum)
PF02446
(Glyco_hydro_77)
3 ARG A 194
ASP A  88
ASN A 256
GOL  A1006 (-3.7A)
None
None
0.60A 2zzmA-1x1nA:
undetectable
2zzmA-1x1nA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN


(Homo sapiens)
PF00102
(Y_phosphatase)
3 ARG A 959
ASP A1020
ASN A 943
None
0.83A 2zzmA-1yguA:
undetectable
2zzmA-1yguA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhn RAS-RELATED PROTEIN
RAB-7


(Homo sapiens)
PF00071
(Ras)
3 ARG A 103
ASP A 114
ASN A 147
None
0.86A 2zzmA-1yhnA:
undetectable
2zzmA-1yhnA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3o TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 6


(Homo sapiens)
PF00017
(SH2)
PF00102
(Y_phosphatase)
3 ARG A 286
ASP A 334
ASN A 270
None
0.79A 2zzmA-2b3oA:
undetectable
2zzmA-2b3oA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b49 PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 3


(Homo sapiens)
PF00102
(Y_phosphatase)
3 ARG A 829
ASP A 834
ASN A 712
None
0.82A 2zzmA-2b49A:
undetectable
2zzmA-2b49A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT


(Hyphomicrobium
denitrificans)
PF01011
(PQQ)
PF13360
(PQQ_2)
3 ARG A 109
ASP A 330
ASN A 394
PQQ  A 601 (-3.2A)
None
PQQ  A 601 (-3.5A)
0.83A 2zzmA-2d0vA:
undetectable
2zzmA-2d0vA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7d UVRABC SYSTEM
PROTEIN B


(Bacillus
subtilis)
PF00271
(Helicase_C)
PF02151
(UVR)
PF04851
(ResIII)
PF12344
(UvrB)
3 ARG A 183
ASP A 198
ASN A 170
None
0.89A 2zzmA-2d7dA:
3.8
2zzmA-2d7dA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fez PROBABLE REGULATORY
PROTEIN EMBR


(Mycobacterium
tuberculosis)
PF00486
(Trans_reg_C)
PF00498
(FHA)
PF03704
(BTAD)
3 ARG A 370
ASP A 343
ASN A 348
None
0.87A 2zzmA-2fezA:
undetectable
2zzmA-2fezA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2foi ENOYL-ACYL CARRIER
REDUCTASE


(Plasmodium
falciparum)
PF13561
(adh_short_C2)
3 ARG A 318
ASP A 168
ASN A 218
None
NAD  A 450 (-3.8A)
NAD  A 450 (-4.1A)
0.73A 2zzmA-2foiA:
5.1
2zzmA-2foiA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjt RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE PTPRO


(Homo sapiens)
PF00102
(Y_phosphatase)
3 ARG A 978
ASP A1020
ASN A 962
None
0.77A 2zzmA-2gjtA:
undetectable
2zzmA-2gjtA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,


(Homo sapiens)
PF00102
(Y_phosphatase)
3 ARG A1743
ASP A1785
ASN A1727
None
MG  A 304 ( 3.8A)
None
0.82A 2zzmA-2h03A:
undetectable
2zzmA-2h03A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE


(Homo sapiens)
PF00102
(Y_phosphatase)
3 ARG A 750
ASP A 793
ASN A 734
None
0.83A 2zzmA-2i1yA:
undetectable
2zzmA-2i1yA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON


(Homo sapiens)
PF00102
(Y_phosphatase)
3 ARG A 467
ASP A 509
ASN A 451
None
0.76A 2zzmA-2jjdA:
undetectable
2zzmA-2jjdA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)


(Homo sapiens)
PF00102
(Y_phosphatase)
3 ARG A 890
ASP A 934
ASN A 874
None
0.86A 2zzmA-2nlkA:
undetectable
2zzmA-2nlkA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nv5 PTPRD, PHOSPHATASE

(Rattus
norvegicus)
PF00102
(Y_phosphatase)
3 ARG A1267
ASP A1309
ASN A1251
None
0.85A 2zzmA-2nv5A:
undetectable
2zzmA-2nv5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T


(Homo sapiens)
PF00102
(Y_phosphatase)
3 ARG A 950
ASP A 992
ASN A 934
None
0.81A 2zzmA-2ooqA:
undetectable
2zzmA-2ooqA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9


(Homo sapiens)
PF00102
(Y_phosphatase)
3 ARG A 343
ASP A 385
ASN A 327
None
0.85A 2zzmA-2pa5A:
undetectable
2zzmA-2pa5A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2


(Homo sapiens)
PF00102
(Y_phosphatase)
3 ARG A 786
ASP A 829
ASN A 770
None
0.71A 2zzmA-2qepA:
undetectable
2zzmA-2qepA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A


(Geobacillus
stearothermophilus)
PF00005
(ABC_tran)
3 ARG A 411
ASP A 106
ASN A 268
None
0.54A 2zzmA-2r6fA:
undetectable
2zzmA-2r6fA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvy PROTEIN B15

(Vaccinia virus)
PF06227
(Poxvirus)
3 ARG A 146
ASP A  24
ASN A 142
None
0.88A 2zzmA-2vvyA:
undetectable
2zzmA-2vvyA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wf7 BETA-PHOSPHOGLUCOMUT
ASE


(Lactococcus
lactis)
PF13419
(HAD_2)
3 ARG A  38
ASP A 170
ASN A  41
None
MG  A1220 (-2.5A)
None
0.84A 2zzmA-2wf7A:
undetectable
2zzmA-2wf7A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yeq ALKALINE PHOSPHATASE
D


(Bacillus
subtilis)
PF09423
(PhoD)
PF16655
(PhoD_N)
3 ARG A 282
ASP A 151
ASN A 216
None
CA  A1525 (-2.4A)
CA  A1526 (-3.3A)
0.85A 2zzmA-2yeqA:
undetectable
2zzmA-2yeqA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqy HYPOTHETICAL PROTEIN
TTHA0303


(Thermus
thermophilus)
PF12867
(DinB_2)
3 ARG A 150
ASP A 128
ASN A 144
None
0.86A 2zzmA-2yqyA:
undetectable
2zzmA-2yqyA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron)
PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C)
3 ARG A  98
ASP A 281
ASN A 120
None
0.84A 2zzmA-3a24A:
undetectable
2zzmA-3a24A:
20.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ay0 UNCHARACTERIZED
PROTEIN MJ0883


(Methanocaldococcus
jannaschii)
PF02475
(Met_10)
3 ARG A 186
ASP A 223
ASN A 265
None
ADN  A 401 (-2.6A)
ADN  A 401 (-4.9A)
0.62A 2zzmA-3ay0A:
36.3
2zzmA-3ay0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckk TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE


(Homo sapiens)
PF02390
(Methyltransf_4)
3 ARG A 216
ASP A 169
ASN A 217
None
0.84A 2zzmA-3ckkA:
10.3
2zzmA-3ckkA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1t TYPE I SITE-SPECIFIC
RESTRICTION-MODIFICA
TION SYSTEM, R
(RESTRICTION)
SUBUNIT


(Vibrio
vulnificus)
PF00271
(Helicase_C)
PF04851
(ResIII)
PF13588
(HSDR_N_2)
3 ARG A 456
ASP A 423
ASN A 461
None
0.83A 2zzmA-3h1tA:
4.5
2zzmA-3h1tA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i36 VASCULAR PROTEIN
TYROSINE PHOSPHATASE
1


(Rattus
norvegicus)
PF00102
(Y_phosphatase)
3 ARG A 960
ASP A1001
ASN A 944
None
0.81A 2zzmA-3i36A:
undetectable
2zzmA-3i36A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij3 CYTOSOL
AMINOPEPTIDASE


(Coxiella
burnetii)
PF00883
(Peptidase_M17)
3 ARG A 120
ASP A 151
ASN A 117
None
0.89A 2zzmA-3ij3A:
undetectable
2zzmA-3ij3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jck 26S PROTEASOME
REGULATORY SUBUNIT
RPN3


(Saccharomyces
cerevisiae)
PF01399
(PCI)
PF08375
(Rpn3_C)
3 ARG A 196
ASP A 375
ASN A 243
None
0.75A 2zzmA-3jckA:
undetectable
2zzmA-3jckA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens)
PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N)
3 ARG A 230
ASP A 500
ASN A 239
None
0.85A 2zzmA-3lppA:
undetectable
2zzmA-3lppA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR


(Legionella
pneumophila)
PF14860
(DrrA_P4M)
3 ARG A 453
ASP A 445
ASN A 451
None
0.89A 2zzmA-3n6oA:
undetectable
2zzmA-3n6oA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A


(Thermotoga
maritima)
PF00005
(ABC_tran)
3 ARG A 391
ASP A 106
ASN A 270
None
0.61A 2zzmA-3pihA:
undetectable
2zzmA-3pihA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6


(Homo sapiens)
PF00017
(SH2)
PF00102
(Y_phosphatase)
3 ARG A 286
ASP A 334
ASN A 270
None
0.90A 2zzmA-3ps5A:
undetectable
2zzmA-3ps5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE


(Sus scrofa)
PF00305
(Lipoxygenase)
3 ARG A 364
ASP A 352
ASN A 544
None
0.82A 2zzmA-3rdeA:
undetectable
2zzmA-3rdeA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2j DIPEPTIDASE

(Streptomyces
coelicolor)
PF01244
(Peptidase_M19)
3 ARG A   8
ASP A 333
ASN A 339
None
0.73A 2zzmA-3s2jA:
undetectable
2zzmA-3s2jA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s3f TYROSINE-PROTEIN
PHOSPHATASE 10D


(Drosophila
melanogaster)
PF00102
(Y_phosphatase)
3 ARG A  86
ASP A 128
ASN A  70
None
0.72A 2zzmA-3s3fA:
undetectable
2zzmA-3s3fA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0a NTNH

(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C)
3 ARG B1043
ASP B1110
ASN B1148
None
0.89A 2zzmA-3v0aB:
undetectable
2zzmA-3v0aB:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi1 ALKALINE
METALLOPROTEINASE


(Pseudomonas
aeruginosa)
PF08548
(Peptidase_M10_C)
PF13583
(Reprolysin_4)
3 ARG A 393
ASP A 435
ASN A 458
None
0.73A 2zzmA-3vi1A:
undetectable
2zzmA-3vi1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A


(Mycobacterium
tuberculosis)
PF00005
(ABC_tran)
3 ARG A 419
ASP A 107
ASN A 276
None
0.43A 2zzmA-3zqjA:
undetectable
2zzmA-3zqjA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A


(Mycobacterium
tuberculosis)
PF00005
(ABC_tran)
3 ARG A 783
ASP A 722
ASN A 747
None
0.58A 2zzmA-3zqjA:
undetectable
2zzmA-3zqjA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aie GLUCAN
1,6-ALPHA-GLUCOSIDAS
E


(Lactobacillus
acidophilus)
PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C)
3 ARG A 177
ASP A 206
ASN A 170
None
0.85A 2zzmA-4aieA:
undetectable
2zzmA-4aieA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au0 EXOGLUCANASE 2

(Trichoderma
reesei)
PF01341
(Glyco_hydro_6)
3 ARG A 353
ASP A 419
ASN A 369
None
0.89A 2zzmA-4au0A:
undetectable
2zzmA-4au0A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S


(Homo sapiens)
PF00102
(Y_phosphatase)
3 ARG A1432
ASP A1474
ASN A1416
None
0.88A 2zzmA-4bpcA:
undetectable
2zzmA-4bpcA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S


(Homo sapiens)
PF00102
(Y_phosphatase)
3 ARG A1721
ASP A1763
ASN A1705
None
0.80A 2zzmA-4bpcA:
undetectable
2zzmA-4bpcA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE


(Mycobacterium
avium)
PF04909
(Amidohydro_2)
3 ARG A 381
ASP A 113
ASN A   5
None
0.88A 2zzmA-4dziA:
undetectable
2zzmA-4dziA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxw ADENOSINE DEAMINASE

(Burkholderia
ambifaria)
PF00962
(A_deaminase)
3 ARG A 272
ASP A 301
ASN A 267
None
0.86A 2zzmA-4gxwA:
undetectable
2zzmA-4gxwA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikc PHOSPHOTIDYLINOSITOL
PHOSPHATASE PTPRQ


(Homo sapiens)
PF00102
(Y_phosphatase)
3 ARG A2722
ASP A2764
ASN A2706
None
0.88A 2zzmA-4ikcA:
undetectable
2zzmA-4ikcA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE


(Francisella
tularensis)
PF00155
(Aminotran_1_2)
3 ARG A 274
ASP A  36
ASN A 273
None
0.79A 2zzmA-4iw7A:
2.2
2zzmA-4iw7A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jat ALPHA-PYRONE
SYNTHESIS POLYKETIDE
SYNTHASE-LIKE PKS11


(Mycobacterium
tuberculosis)
PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C)
3 ARG A 207
ASP A  97
ASN A  92
None
0.61A 2zzmA-4jatA:
undetectable
2zzmA-4jatA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqn D-HYDANTOINASE

(Bacillus sp.
AR9)
PF01979
(Amidohydro_1)
3 ARG A  79
ASP A  62
ASN A 412
ARG  A  79 ( 0.6A)
ASP  A  62 ( 0.6A)
ASN  A 412 ( 0.6A)
0.89A 2zzmA-4kqnA:
undetectable
2zzmA-4kqnA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1a CELL
DIVISIONFTSK/SPOIIIE


(Thermomonospora
curvata)
PF01580
(FtsK_SpoIIIE)
3 ARG A 996
ASP A1006
ASN A1012
None
0.83A 2zzmA-4n1aA:
1.9
2zzmA-4n1aA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnd TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 18


(Homo sapiens)
PF00102
(Y_phosphatase)
3 ARG A  72
ASP A 114
ASN A  56
None
0.79A 2zzmA-4nndA:
undetectable
2zzmA-4nndA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN


(Chloroflexus
aurantiacus)
PF13407
(Peripla_BP_4)
3 ARG A 142
ASP A 145
ASN A 347
None
0.75A 2zzmA-4rxuA:
undetectable
2zzmA-4rxuA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3o E3 UBIQUITIN-PROTEIN
LIGASE RING2
POLYCOMB GROUP RING
FINGER PROTEIN 5


(Homo sapiens;
Homo sapiens)
PF13923
(zf-C3HC4_2)
PF13923
(zf-C3HC4_2)
3 ARG C  55
ASP C  72
ASN B 105
None
0.86A 2zzmA-4s3oC:
undetectable
2zzmA-4s3oC:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT


(Methylococcus
capsulatus)
no annotation 3 ARG B 137
ASP B 357
ASN B 421
PQQ  B 702 (-3.0A)
None
PQQ  B 702 (-3.7A)
0.80A 2zzmA-4tqoB:
undetectable
2zzmA-4tqoB:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uu2 FERULIC ACID
DECARBOXYLASE


(Enterobacter
sp.)
PF05870
(PA_decarbox)
3 ARG A 142
ASP A  38
ASN A 148
None
0.87A 2zzmA-4uu2A:
undetectable
2zzmA-4uu2A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN


(Mycolicibacterium
thermoresistibile)
PF00722
(Glyco_hydro_16)
3 ARG A 117
ASP A  30
ASN A  80
BEZ  A 306 (-3.5A)
None
None
0.75A 2zzmA-4xdqA:
undetectable
2zzmA-4xdqA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqe HOMOSPERMIDINE
SYNTHASE


(Blastochloris
viridis)
PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C)
3 ARG A 211
ASP A 358
ASN A 329
None
0.70A 2zzmA-4xqeA:
3.5
2zzmA-4xqeA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE


(Saccharophagus
degradans)
PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36)
3 ARG A 349
ASP A 345
ASN A 350
LGC  A 804 (-4.0A)
GOL  A 802 (-3.0A)
LGC  A 804 (-3.0A)
0.76A 2zzmA-4zlgA:
undetectable
2zzmA-4zlgA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE


(Homo sapiens)
PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
PF09336
(Vps4_C)
3 ARG A  95
ASP A 204
ASN A  90
None
0.67A 2zzmA-5c1bA:
undetectable
2zzmA-5c1bA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC


(Arabidopsis
thaliana)
PF02446
(Glyco_hydro_77)
3 ARG A 246
ASP A 140
ASN A 308
None
0.80A 2zzmA-5csuA:
undetectable
2zzmA-5csuA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgq PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN


(Photobacterium
profundum)
PF00759
(Glyco_hydro_9)
3 ARG A 364
ASP A 303
ASN A 308
None
0.88A 2zzmA-5dgqA:
undetectable
2zzmA-5dgqA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ek8 LIPOXYGENASE

(Cyanothece sp.
PCC 8801)
PF00305
(Lipoxygenase)
3 ARG A 487
ASP A 551
ASN A 545
None
0.82A 2zzmA-5ek8A:
undetectable
2zzmA-5ek8A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h08 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA


(Homo sapiens)
PF00102
(Y_phosphatase)
3 ARG A1766
ASP A1810
ASN A1750
None
0.84A 2zzmA-5h08A:
undetectable
2zzmA-5h08A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11


(Homo sapiens)
PF00017
(SH2)
PF00102
(Y_phosphatase)
3 ARG A 289
ASP A 340
ASN A 273
None
0.90A 2zzmA-5i6vA:
undetectable
2zzmA-5i6vA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m7r PROTEIN O-GLCNACASE

(Homo sapiens)
PF07555
(NAGidase)
3 ARG A 610
ASP A 600
ASN A 588
None
0.79A 2zzmA-5m7rA:
undetectable
2zzmA-5m7rA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mj7 UNCHARACTERIZED
PROTEIN


(Caenorhabditis
elegans)
PF01156
(IU_nuc_hydro)
3 ARG A 286
ASP A 277
ASN A 281
None
0.75A 2zzmA-5mj7A:
2.8
2zzmA-5mj7A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no8 BACCELL_00875

(Bacteroides
cellulosilyticus)
no annotation 3 ARG A 395
ASP A 441
ASN A 379
None
0.78A 2zzmA-5no8A:
undetectable
2zzmA-5no8A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9w THEBAINE
6-O-DEMETHYLASE


(Papaver
somniferum)
no annotation 3 ARG A 305
ASP A 144
ASN A 221
AKG  A 402 (-2.7A)
None
AKG  A 402 (-3.7A)
0.86A 2zzmA-5o9wA:
undetectable
2zzmA-5o9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olj DIPEPTIDYL PEPTIDASE
IV


(Porphyromonas
gingivalis)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
3 ARG A 635
ASP A 273
ASN A 300
None
0.81A 2zzmA-5oljA:
undetectable
2zzmA-5oljA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ols RHAMNOGALACTURONAN
LYASE


(Bacteroides
thetaiotaomicron)
no annotation 3 ARG A 319
ASP A 215
ASN A 324
GTR  A 608 (-3.0A)
CA  A 601 (-2.1A)
RAM  A 607 (-2.8A)
0.78A 2zzmA-5olsA:
undetectable
2zzmA-5olsA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tt0 OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY


(Burkholderia
thailandensis)
PF13561
(adh_short_C2)
3 ARG A  74
ASP A  68
ASN A  72
None
EDO  A 307 ( 4.5A)
None
0.84A 2zzmA-5tt0A:
6.9
2zzmA-5tt0A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucr PANTOTHENATE
SYNTHETASE


(Neisseria
gonorrhoeae)
PF02569
(Pantoate_ligase)
3 ARG A  41
ASP A 139
ASN A  46
None
0.86A 2zzmA-5ucrA:
2.4
2zzmA-5ucrA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN 70
KDA HOMOLOG
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN C


(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae)
no annotation
no annotation
3 ARG B 124
ASP B 103
ASN A   2
None
0.76A 2zzmA-5uz5B:
undetectable
2zzmA-5uz5B:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdu BNAB NIH45-46 SCFV
HEAVY CHAIN


(Homo sapiens)
no annotation 3 ARG D  53
ASP D  76
ASN D  31
None
0.62A 2zzmA-5wduD:
undetectable
2zzmA-5wduD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcy GLUCANASE

(Phanerochaete
chrysosporium)
PF01341
(Glyco_hydro_6)
3 ARG A 347
ASP A 412
ASN A 362
None
0.89A 2zzmA-5xcyA:
undetectable
2zzmA-5xcyA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfm ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron)
no annotation 3 ARG A 392
ASP A 427
ASN A 386
None
0.86A 2zzmA-5xfmA:
undetectable
2zzmA-5xfmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xm3 GLUCOSE
DEHYDROGENASE


(Methylophaga
aminisulfidivorans)
no annotation 3 ARG A 140
ASP A 361
ASN A 425
PQQ  A 701 (-3.3A)
None
PQQ  A 701 (-3.4A)
0.83A 2zzmA-5xm3A:
undetectable
2zzmA-5xm3A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B


(Pyrococcus
abyssi)
PF02475
(Met_10)
3 ARG A 173
ASP A 211
ASN A 252
None
0.60A 2zzmA-5yacA:
31.0
2zzmA-5yacA:
42.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bs7 ADENYLOSUCCINATE
SYNTHETASE


(Legionella
pneumophila)
no annotation 3 ARG A 148
ASP A 204
ASN A  71
None
0.76A 2zzmA-6bs7A:
2.1
2zzmA-6bs7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwe PUTATIVE FIMBRIAL
ASSOCIATED
SORTASE-LIKE PROTEIN


(Corynebacterium
diphtheriae)
no annotation 3 ARG A 235
ASP A 204
ASN A 198
None
0.72A 2zzmA-6bweA:
undetectable
2zzmA-6bweA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d1w POLYCYSTIN-2

(Homo sapiens)
no annotation 3 ARG A 440
ASP A 394
ASN A 547
None
0.80A 2zzmA-6d1wA:
undetectable
2zzmA-6d1wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae)
no annotation 3 ARG A 827
ASP A1309
ASN A  35
None
0.83A 2zzmA-6eojA:
undetectable
2zzmA-6eojA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fi2 VEXL

(Achromobacter
denitrificans)
no annotation 3 ARG A 172
ASP A 122
ASN A 151
None
0.78A 2zzmA-6fi2A:
undetectable
2zzmA-6fi2A:
undetectable