SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZZM_A_SAMA401_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aow ANNEXIN IV

(Bos taurus) 		PF00191
(Annexin) 		5 LEU A 193
GLY A 157
ILE A 123
ASN A 124
ASP A  90
 None
 1.15A 2zzmA-1aowA:
0.0		 2zzmA-1aowA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE

(Rattus
norvegicus) 		PF00106
(adh_short) 		5 ARG A  29
GLY A  23
ILE A 151
VAL A  87
LEU A  30
 None
 1.18A 2zzmA-1e6wA:
6.6		 2zzmA-1e6wA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Thermotoga
maritima) 		PF01380
(SIS) 		5 PHE A  45
GLY A  47
PRO A  74
ILE A 121
PHE A  62
 None
 1.03A 2zzmA-1j5xA:
2.1		 2zzmA-1j5xA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1my6 IRON (III)
SUPEROXIDE DISMUTASE

(Thermosynechococcus
elongatus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 TYR A  17
GLY A  91
ASN A 184
LEU A  86
PHE A  82
 None
 1.21A 2zzmA-1my6A:
0.0		 2zzmA-1my6A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7r HYALURONIDASE

(Streptococcus
pneumoniae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 LEU A 813
PHE A 679
GLY A 794
LEU A 797
PHE A 594
 None
 1.24A 2zzmA-1n7rA:
0.0		 2zzmA-1n7rA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oll NK RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A 102
GLY A 168
PRO A 100
VAL A  92
PHE A  13
 None
 1.22A 2zzmA-1ollA:
undetectable		 2zzmA-1ollA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p6f NATURAL CYTOTOXICITY
TRIGGERING RECEPTOR
1

(Homo sapiens) 		no annotation 5 LEU A 105
GLY A 171
PRO A 103
VAL A  95
PHE A  16
 None
 1.20A 2zzmA-1p6fA:
0.0		 2zzmA-1p6fA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhl PROTEIN (CELL
DIVISION PROTEIN
MUKB)

(Escherichia
coli) 		PF04310
(MukB) 		5 ARG A   8
PHE A   7
GLY A   5
ILE A 183
ASN A  94
 None
 1.05A 2zzmA-1qhlA:
0.0		 2zzmA-1qhlA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkx CDP-GLUCOSE-4,6-DEHY
DRATASE

(Yersinia
pseudotuberculosis) 		PF16363
(GDP_Man_Dehyd) 		5 ARG A 192
PHE A 262
GLY A 194
PRO A 231
ILE A 130
 None
None
NAD  A 360 (-3.5A)
None
NAD  A 360 (-4.8A)
 0.87A 2zzmA-1rkxA:
4.5		 2zzmA-1rkxA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sji CALSEQUESTRIN,
CARDIAC MUSCLE
ISOFORM

(Canis lupus) 		PF01216
(Calsequestrin) 		5 TYR A 160
PHE A 176
GLY A 150
VAL A 222
PHE A 170
 None
 1.19A 2zzmA-1sjiA:
undetectable		 2zzmA-1sjiA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0u HYPOTHETICAL
METHYLMALONYL-COA
DECARBOXYLASE ALPHA
SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01039
(Carboxyl_trans) 		5 PHE A 338
PRO A 289
ILE A 342
ASN A 333
VAL A 374
 None
 1.06A 2zzmA-1x0uA:
undetectable		 2zzmA-1x0uA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp8 RECA PROTEIN

(Deinococcus
radiodurans) 		PF00154
(RecA) 		5 PHE A 203
PRO A  69
ILE A 204
VAL A 155
LEU A 227
 None
 1.19A 2zzmA-1xp8A:
1.3		 2zzmA-1xp8A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d) 		5 LEU A 137
PHE A 315
GLY A 284
ILE A 237
PHE A 114
 None
 1.18A 2zzmA-2amcA:
undetectable		 2zzmA-2amcA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e2n HEXOKINASE

(Sulfurisphaera
tokodaii) 		PF01869
(BcrAD_BadFG) 		5 ARG A 153
LEU A 181
ILE A 219
ASP A 218
VAL A 215
 None
 1.16A 2zzmA-2e2nA:
undetectable		 2zzmA-2e2nA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES

(Escherichia
coli) 		PF07995
(GSDH) 		5 GLY A 130
PRO A 196
VAL A  69
LEU A 140
PHE A 134
 None
 1.06A 2zzmA-2g8sA:
undetectable		 2zzmA-2g8sA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Aquifex
aeolicus) 		PF03331
(LpxC) 		5 TYR A  23
GLY A  17
ILE A  74
ASN A  99
LEU A  26
 None
 1.23A 2zzmA-2go4A:
undetectable		 2zzmA-2go4A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2y FUSION PROTEIN
CONSISTS OF
IMMUNOGLOBULIN
G-BINDING PROTEIN G
AND SPLICING FACTOR,
ARGININE/SERINE-RICH
3

(Streptococcus
sp. 'group G';
Homo sapiens) 		PF00076
(RRM_1)
PF01378
(IgG_binding_B) 		5 ARG A  92
TYR A  96
PHE A  94
GLY A  98
VAL A 115
 None
 1.11A 2zzmA-2i2yA:
2.9		 2zzmA-2i2yA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is5 HYPOTHETICAL PROTEIN

(Neisseria
meningitidis) 		PF05838
(Glyco_hydro_108)
PF09374
(PG_binding_3) 		5 GLY A  18
ILE A  34
VAL A  86
LEU A  13
PHE A  82
 None
 1.13A 2zzmA-2is5A:
undetectable		 2zzmA-2is5A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mev MENGO VIRUS COAT
PROTEIN (SUBUNIT
VP2)
MENGO VIRUS COAT
PROTEIN (SUBUNIT
VP3)

(Cardiovirus A;
Cardiovirus A) 		PF00073
(Rhv)
PF00073
(Rhv) 		5 ARG 2 101
LEU 2 248
GLY 3 132
PRO 3 130
LEU 2 100
 None
 1.20A 2zzmA-2mev2:
undetectable		 2zzmA-2mev2:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		5 ARG A 487
PHE A 486
GLY A 151
ILE A 154
PHE A 453
 None
 1.13A 2zzmA-2okxA:
undetectable		 2zzmA-2okxA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qne PUTATIVE
METHYLTRANSFERASE

(Desulfitobacterium
hafniense) 		PF06253
(MTTB) 		5 LEU A 181
GLY A 163
ILE A 225
LEU A  72
PHE A  70
 None
EDO  A 477 ( 4.6A)
None
None
None
 0.97A 2zzmA-2qneA:
undetectable		 2zzmA-2qneA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		5 GLY A 807
PRO A 462
ILE A 782
VAL A 800
LEU A 572
 None
 1.22A 2zzmA-2vz9A:
undetectable		 2zzmA-2vz9A:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7q OUTER-MEMBRANE
LIPOPROTEIN CARRIER
PROTEIN

(Pseudomonas
aeruginosa) 		PF03548
(LolA) 		5 PHE A  67
GLY A  65
ILE A  80
ASN A  82
LEU A 111
 None
 0.99A 2zzmA-2w7qA:
undetectable		 2zzmA-2w7qA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz8 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN LF

(Drosophila
melanogaster) 		no annotation 5 PHE A 332
GLY A 305
ILE A 309
ASN A 308
PHE A 263
 None
 1.23A 2zzmA-2xz8A:
undetectable		 2zzmA-2xz8A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK

([Ruminococcus]
gnavus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		5 ARG A 194
LEU A 304
GLY A 553
ASN A 204
PHE A 257
 None
 1.20A 2zzmA-2yfnA:
undetectable		 2zzmA-2yfnA:
17.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3a27 UNCHARACTERIZED
PROTEIN MJ1557

(Methanocaldococcus
jannaschii) 		PF02475
(Met_10) 		5 PHE A 104
GLY A 106
ASN A 129
ASP A 154
PHE A 178
 SAM  A 250 (-4.7A)
SAM  A 250 (-3.6A)
None
SAM  A 250 (-3.2A)
SAM  A 250 (-4.6A)
 0.54A 2zzmA-3a27A:
26.0		 2zzmA-3a27A:
31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ay0 UNCHARACTERIZED
PROTEIN MJ0883

(Methanocaldococcus
jannaschii) 		PF02475
(Met_10) 		11 TYR A 177
LEU A 182
PHE A 203
GLY A 205
PRO A 208
ILE A 224
ASN A 225
ASP A 251
VAL A 252
LEU A 266
PHE A 273
 ADN  A 401 (-4.3A)
None
ADN  A 401 (-4.9A)
ADN  A 401 ( 4.0A)
None
ADN  A 401 (-3.7A)
ADN  A 401 (-4.9A)
ADN  A 401 (-3.8A)
ADN  A 401 (-3.9A)
ADN  A 401 ( 4.7A)
ADN  A 401 (-4.6A)
 0.51A 2zzmA-3ay0A:
36.3		 2zzmA-3ay0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 PHE A3191
PRO A3057
ILE A3192
VAL A3143
LEU A3215
 None
 1.22A 2zzmA-3cmtA:
undetectable		 2zzmA-3cmtA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 PHE A2191
PRO A2057
ILE A2192
VAL A2143
LEU A2215
 None
 1.24A 2zzmA-3cmvA:
undetectable		 2zzmA-3cmvA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dli METHYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF13489
(Methyltransf_23) 		5 PHE A 351
GLY A 292
ILE A 312
ASN A 313
ASP A 330
 None
 0.72A 2zzmA-3dliA:
13.3		 2zzmA-3dliA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmy PROTEIN FDRA

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 LEU A 153
PRO A 173
ILE A 199
VAL A 259
LEU A 231
 None
 1.18A 2zzmA-3dmyA:
undetectable		 2zzmA-3dmyA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0s UNCHARACTERIZED
PROTEIN

(Chlorobaculum
tepidum) 		PF05235
(CHAD) 		5 ARG A 267
LEU A 229
ILE A 412
ASP A 413
LEU A 268
 None
 1.17A 2zzmA-3e0sA:
undetectable		 2zzmA-3e0sA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1

(Homo sapiens) 		PF00616
(RasGAP) 		5 LEU A1030
GLY A1159
VAL A1153
LEU A1191
PHE A1265
 None
 1.15A 2zzmA-3fayA:
undetectable		 2zzmA-3fayA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5a FMN
ADENYLYLTRANSFERASE

([Candida]
glabrata) 		PF01507
(PAPS_reduct) 		5 LEU A 205
GLY A 287
ASN A 232
LEU A 223
PHE A 114
 None
None
None
APC  A 305 (-4.4A)
None
 1.16A 2zzmA-3g5aA:
undetectable		 2zzmA-3g5aA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7u CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Escherichia
coli) 		PF00145
(DNA_methylase) 		5 PHE A   7
GLY A   9
ILE A  30
ASP A  51
VAL A  52
 None
 0.71A 2zzmA-3g7uA:
8.5		 2zzmA-3g7uA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkb PUTATIVE ENOYL-COA
HYDRATASE

(Streptomyces
avermitilis) 		PF00378
(ECH_1) 		5 LEU A 268
GLY A 113
VAL A 109
LEU A  65
PHE A 122
 None
 1.02A 2zzmA-3gkbA:
undetectable		 2zzmA-3gkbA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN HEAVY CHAIN
ISOFORM A

(Doryteuthis
pealeii) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF02736
(Myosin_N) 		5 LEU A 390
ILE A 302
ASN A 301
VAL A 308
LEU A 361
 None
 0.94A 2zzmA-3i5gA:
undetectable		 2zzmA-3i5gA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifq PLAKOGLOBIN
E-CADHERIN

(Homo sapiens;
Mus musculus) 		PF00514
(Arm)
PF01049
(Cadherin_C) 		5 GLY A 640
ILE C 657
ASN C 660
VAL A 648
LEU A 634
 None
 1.14A 2zzmA-3ifqA:
undetectable		 2zzmA-3ifqA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		5 TYR W 556
PHE W 554
GLY W 520
VAL W 552
LEU W 564
 None
 0.96A 2zzmA-3iylW:
8.6		 2zzmA-3iylW:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcc PUTATIVE METHYL
CHLORIDE TRANSFERASE

(Arabidopsis
thaliana) 		PF05724
(TPMT) 		5 PHE A 141
GLY A  76
ILE A  96
ASP A 123
VAL A 124
 SAH  A 300 (-4.6A)
SAH  A 300 (-3.5A)
SAH  A 300 (-4.2A)
SAH  A 300 (-3.8A)
SAH  A 300 (-4.1A)
 0.79A 2zzmA-3lccA:
14.4		 2zzmA-3lccA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mae 2-OXOISOVALERATE
DEHYDROGENASE E2
COMPONENT,
DIHYDROLIPOAMIDE
ACETYLTRANSFERASE

(Listeria
monocytogenes) 		PF00198
(2-oxoacid_dh) 		5 PHE A 331
ILE A 277
ASN A 278
VAL A 252
PHE A 397
 None
 1.21A 2zzmA-3maeA:
undetectable		 2zzmA-3maeA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		5 TYR A  82
GLY A  94
ILE A 263
LEU A  84
PHE A 423
 None
 1.24A 2zzmA-3mpnA:
undetectable		 2zzmA-3mpnA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0v FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Pseudomonas
putida) 		PF00551
(Formyl_trans_N) 		5 ARG A 109
TYR A 108
ILE A  94
VAL A  92
LEU A 115
 None
 1.19A 2zzmA-3n0vA:
4.9		 2zzmA-3n0vA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nip 3-GUANIDINOPROPIONAS
E

(Pseudomonas
aeruginosa) 		PF00491
(Arginase) 		5 LEU A   9
PHE A  23
GLY A  86
ILE A  40
VAL A 122
 None
 1.23A 2zzmA-3nipA:
undetectable		 2zzmA-3nipA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqp SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 LEU A 507
GLY A  76
ILE A  79
ASN A 344
LEU A  96
 None
None
EDO  A1004 ( 3.8A)
None
None
 1.18A 2zzmA-3nqpA:
undetectable		 2zzmA-3nqpA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		5 ARG A 254
LEU A 735
PHE A 221
PRO A  27
ILE A 210
 None
 1.12A 2zzmA-3pieA:
2.8		 2zzmA-3pieA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qiv SHORT-CHAIN
DEHYDROGENASE OR
3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		5 GLY A  14
ILE A  37
ASN A  38
ASP A  62
VAL A  63
 None
 0.89A 2zzmA-3qivA:
7.3		 2zzmA-3qivA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3so2 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chlorella
variabilis) 		PF00692
(dUTPase) 		5 GLY A  91
ASP A 108
VAL A 104
LEU A  94
PHE A 102
 None
 1.22A 2zzmA-3so2A:
undetectable		 2zzmA-3so2A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 GLY A 416
PRO A 419
ASN A 452
ASP A 477
LEU A 500
 None
 1.22A 2zzmA-3ua4A:
7.8		 2zzmA-3ua4A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvd AMINO ACID ABC
TRANSPORTER, BINDING
PROTEIN

(Thermus
thermophilus) 		PF00497
(SBP_bac_3) 		5 LEU A  34
PHE A  37
ASP A 232
VAL A 233
LEU A  41
 None
 1.21A 2zzmA-3vvdA:
undetectable		 2zzmA-3vvdA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		5 TYR A2253
LEU A1949
PHE A1992
ILE A1960
PHE A2080
 None
 1.23A 2zzmA-4asiA:
undetectable		 2zzmA-4asiA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmr RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus cereus) 		PF00268
(Ribonuc_red_sm) 		5 TYR A 171
LEU A 249
GLY A 168
ILE A 191
LEU A 173
 None
 1.17A 2zzmA-4bmrA:
undetectable		 2zzmA-4bmrA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 PHE A 124
GLY A 158
ILE A 285
ASP A 344
LEU A 151
 None
 1.06A 2zzmA-4bziA:
undetectable		 2zzmA-4bziA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN

(Escherichia
coli) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 ARG A  79
GLY A  71
ILE A  77
VAL A  55
PHE A  51
 None
 1.07A 2zzmA-4c7oA:
undetectable		 2zzmA-4c7oA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex4 MALATE SYNTHASE G

(Mycobacterium
leprae) 		PF01274
(Malate_synthase) 		5 LEU A 381
GLY A 426
PRO A 428
VAL A  39
LEU A 375
 None
 1.21A 2zzmA-4ex4A:
undetectable		 2zzmA-4ex4A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 HSL7 PROTEIN

(Xenopus laevis) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 GLY A 363
PRO A 366
ASN A 390
ASP A 415
LEU A 432
 SAH  A 701 ( 4.1A)
None
None
SAH  A 701 (-2.8A)
SAH  A 701 (-4.5A)
 0.92A 2zzmA-4g56A:
8.9		 2zzmA-4g56A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Homo sapiens) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 GLY A 367
PRO A 370
ASN A 394
ASP A 419
LEU A 436
 0XU  A 701 ( 3.7A)
0XU  A 701 (-4.2A)
None
0XU  A 701 (-2.9A)
None
 0.87A 2zzmA-4gqbA:
9.4		 2zzmA-4gqbA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0u THYMIDYLATE SYNTHASE

(Corynebacterium
glutamicum) 		PF00303
(Thymidylat_synt) 		5 LEU A 162
ASN A 236
VAL A 251
LEU A 186
PHE A  55
 None
 1.14A 2zzmA-4h0uA:
undetectable		 2zzmA-4h0uA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		5 LEU A 240
GLY A 196
PRO A 199
ILE A 146
LEU A 227
 None
 1.18A 2zzmA-4idmA:
4.3		 2zzmA-4idmA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imd N-ACETYLNEURAMINATE
LYASE

(Pasteurella
multocida) 		PF00701
(DHDPS) 		5 PHE A 109
GLY A 143
ILE A 138
VAL A 106
PHE A  52
 None
 1.23A 2zzmA-4imdA:
undetectable		 2zzmA-4imdA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Paracoccus
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 166
ILE A 174
VAL A 177
LEU A 218
PHE A 216
 None
 1.11A 2zzmA-4izgA:
undetectable		 2zzmA-4izgA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 PHE A 114
GLY A 117
ASN A  94
VAL A  46
LEU A 109
 None
 1.05A 2zzmA-4j0mA:
undetectable		 2zzmA-4j0mA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcn GLUTAMYL
ENDOPEPTIDASE

(Staphylococcus
epidermidis) 		PF13365
(Trypsin_2) 		5 GLY A 124
ILE A  93
ASN A 128
VAL A 118
LEU A 163
 None
 1.21A 2zzmA-4jcnA:
undetectable		 2zzmA-4jcnA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 HEAVY
CHAIN
MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 LIGHT
CHAIN

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 PHE L  98
GLY L 100
VAL H  37
LEU L  89
PHE H  96
 None
 1.20A 2zzmA-4jo2L:
undetectable		 2zzmA-4jo2L:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 GLY A 551
ILE A 555
ASN A 554
VAL A 629
LEU A 617
 None
 1.06A 2zzmA-4kxbA:
undetectable		 2zzmA-4kxbA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ooq DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Arabidopsis
thaliana) 		PF00692
(dUTPase) 		5 ARG A  88
ILE A  69
VAL A  61
LEU A  91
PHE A 124
 None
 1.16A 2zzmA-4ooqA:
undetectable		 2zzmA-4ooqA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4owt INTEGRATOR COMPLEX
SUBUNIT 3
SOSS COMPLEX SUBUNIT
C

(Homo sapiens;
Homo sapiens) 		PF10189
(Ints3)
PF15925
(SOSSC) 		5 ARG A 263
TYR C  82
LEU C 101
ASN A 260
VAL A 233
 None
 1.09A 2zzmA-4owtA:
undetectable		 2zzmA-4owtA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlp ALANINE AND PROLINE
RICH PROTEIN,
TUBERCULOSIS
NECROTIZING TOXIN
(TNT)

(Mycobacterium
tuberculosis) 		PF14021
(TNT) 		5 ARG B 713
GLY B 813
ASN B 726
VAL B 784
PHE B 696
 None
 1.17A 2zzmA-4qlpB:
undetectable		 2zzmA-4qlpB:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlp ALANINE AND PROLINE
RICH PROTEIN,
TUBERCULOSIS
NECROTIZING TOXIN
(TNT)

(Mycobacterium
tuberculosis) 		PF14021
(TNT) 		5 ARG B 713
PRO B 812
ASN B 726
VAL B 784
PHE B 696
 None
 1.15A 2zzmA-4qlpB:
undetectable		 2zzmA-4qlpB:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB

(Drosophila
melanogaster) 		PF10613
(Lig_chan-Glu_bd) 		5 GLY A  18
PRO A  20
ASN A 180
ASP A  65
VAL A  63
 None
 1.23A 2zzmA-4wxjA:
undetectable		 2zzmA-4wxjA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxc FLAGELLAR ASSEMBLY
PROTEIN H,ENDOLYSIN

(Escherichia
virus T4;
Salmonella
enterica) 		PF00959
(Phage_lysozyme) 		5 LEU A  36
PHE A  88
ASP A  93
VAL A  92
PHE A  25
 None
 1.22A 2zzmA-4yxcA:
undetectable		 2zzmA-4yxcA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aor DOSAGE COMPENSATION
REGULATOR

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		5 LEU A 859
GLY A1007
VAL A 999
LEU A 874
PHE A 878
 None
 1.09A 2zzmA-5aorA:
3.7		 2zzmA-5aorA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd7 MATERNAL EFFECT
PROTEIN OSKAR

(Drosophila
melanogaster) 		PF12872
(OST-HTH) 		5 PHE A 189
ASN A 187
VAL A 160
LEU A 191
PHE A 198
 None
 1.18A 2zzmA-5cd7A:
undetectable		 2zzmA-5cd7A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		5 PRO A 132
ILE A 225
ASN A 176
VAL A 216
PHE A 180
 None
 1.14A 2zzmA-5d0fA:
undetectable		 2zzmA-5d0fA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dhx ANTI-REV ANTIBODY
FAB SINGLE-CHAIN
VARIABLE FRAGMENT,
LIGHT CHAIN,ANTI-REV
ANTIBODY FAB
SINGLE-CHAIN
VARIABLE FRAGMENT,
HEAVY CHAIN

(Oryctolagus
cuniculus) 		PF07686
(V-set) 		5 PHE B 101
GLY B 103
VAL B 147
LEU B  89
PHE B 214
 None
 1.23A 2zzmA-5dhxB:
undetectable		 2zzmA-5dhxB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia annua) 		PF00724
(Oxidored_FMN) 		5 LEU A 272
ILE A  62
VAL A 159
LEU A 187
PHE A 212
 None
 1.13A 2zzmA-5dxxA:
undetectable		 2zzmA-5dxxA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e72 N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE

(Thermococcus
kodakarensis) 		PF01170
(UPF0020)
PF02926
(THUMP) 		5 LEU A 165
PHE A 187
GLY A 189
ILE A 209
ASP A 235
 None
SAM  A 400 (-4.7A)
SAM  A 400 (-3.3A)
SAM  A 400 (-3.9A)
SAM  A 400 (-3.4A)
 0.87A 2zzmA-5e72A:
16.8		 2zzmA-5e72A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5egn ESTERASE

(uncultured
bacterium) 		PF12697
(Abhydrolase_6) 		5 LEU A 199
GLY A  96
ASN A  92
LEU A 122
PHE A 191
 None
 1.03A 2zzmA-5egnA:
undetectable		 2zzmA-5egnA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffj ENDONUCLEASE AND
METHYLASE LLAGI

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII) 		5 TYR A1403
LEU A1431
GLY A1441
ILE A1360
LEU A1408
 None
 1.22A 2zzmA-5ffjA:
10.9		 2zzmA-5ffjA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fod LEUCYL-TRNA
SYNTHETASE

(Plasmodium
falciparum) 		no annotation 5 PHE A 391
GLY A 393
ILE A 390
VAL A 283
PHE A 289
 None
 1.19A 2zzmA-5fodA:
undetectable		 2zzmA-5fodA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghe PESTICIDAL CRYSTAL
PROTEIN CRY6AA

(Bacillus
thuringiensis) 		no annotation 5 PHE A 186
GLY A 189
ILE A 200
ASN A 199
ASP A  90
 None
 1.03A 2zzmA-5gheA:
undetectable		 2zzmA-5gheA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5has SEC7

(Thielavia
terrestris) 		PF12783
(Sec7_N)
PF16213
(DCB) 		5 LEU A 169
PHE A 177
ILE A 355
ASN A 352
VAL A 357
 None
 1.06A 2zzmA-5hasA:
undetectable		 2zzmA-5hasA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvm ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Aspergillus
fumigatus) 		PF00982
(Glyco_transf_20) 		5 LEU A 154
GLY A 175
PRO A 158
LEU A  16
PHE A  55
 None
 1.15A 2zzmA-5hvmA:
2.3		 2zzmA-5hvmA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icq METHYLOCYSTIS PARVUS
OBBP MBNE

(Methylocystis
parvus) 		PF00496
(SBP_bac_5) 		6 ARG A 339
PHE A 342
PRO A 406
VAL A 471
LEU A 338
PHE A 444
 None
 1.39A 2zzmA-5icqA:
undetectable		 2zzmA-5icqA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcn OS09G0567300 PROTEIN

(Oryza sativa) 		PF07992
(Pyr_redox_2) 		5 TYR A 174
LEU A 203
GLY A 172
VAL A 221
PHE A 353
 NAD  A 501 (-3.6A)
None
NAD  A 501 ( 4.5A)
None
None
 1.17A 2zzmA-5jcnA:
undetectable		 2zzmA-5jcnA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy1 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Paraburkholderia
xenovorans) 		PF13561
(adh_short_C2) 		5 GLY A  15
ILE A  38
ASN A  39
ASP A  63
VAL A  64
 NAD  A 301 ( 4.2A)
NAD  A 301 (-3.7A)
None
NAD  A 301 (-3.8A)
NAD  A 301 (-3.6A)
 0.86A 2zzmA-5jy1A:
6.8		 2zzmA-5jy1A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		5 LEU A 242
PHE A 309
GLY A 319
ILE A 312
PHE A 270
 None
None
None
CU  A 808 ( 4.9A)
None
 1.10A 2zzmA-5k8dA:
undetectable		 2zzmA-5k8dA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA

(Bacillus
thuringiensis) 		no annotation 5 PHE A 186
GLY A 189
ILE A 200
ASN A 199
ASP A  90
 None
 0.88A 2zzmA-5kucA:
undetectable		 2zzmA-5kucA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3r SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN,
CHLOROPLASTIC
CELL DIVISION
PROTEIN FTSY
HOMOLOG,
CHLOROPLASTIC

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF00448
(SRP54)
PF02881
(SRP54_N) 		5 LEU A 115
PHE B 109
VAL B 144
LEU B 104
PHE B 365
 None
 1.23A 2zzmA-5l3rA:
undetectable		 2zzmA-5l3rA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lwe C-C CHEMOKINE
RECEPTOR TYPE 9

(Homo sapiens) 		PF00001
(7tm_1) 		5 LEU A  87
GLY A  65
VAL A  58
LEU A 312
PHE A 308
 79K  A 401 (-4.3A)
OLA  A 412 ( 4.1A)
None
CLR  A 417 ( 4.7A)
OLA  A 402 (-4.1A)
 1.01A 2zzmA-5lweA:
undetectable		 2zzmA-5lweA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m11 IMMUNOREACTIVE 84KD
ANTIGEN PG93

(Porphyromonas
gingivalis) 		no annotation 5 ARG A 424
LEU A 457
ASN A 389
VAL A 362
PHE A 416
 None
 1.05A 2zzmA-5m11A:
undetectable		 2zzmA-5m11A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5od2 BIFUNCTIONAL
ADP-SPECIFIC
GLUCOKINASE/PHOSPHOF
RUCTOKINASE

(Methanocaldococcus
jannaschii) 		no annotation 5 LEU A 354
ILE A 309
ASN A 305
LEU A 335
PHE A 339
 None
 1.23A 2zzmA-5od2A:
3.7		 2zzmA-5od2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oet GLUTATHIONE
SYNTHETASE-LIKE
EFFECTOR 30
(GPA-GSS30-APO)

(Globodera
pallida) 		no annotation 5 PHE B 101
PRO B 473
ASP B 106
VAL B 105
LEU B 524
 None
 1.14A 2zzmA-5oetB:
undetectable		 2zzmA-5oetB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovl 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG

(Mycolicibacterium
smegmatis) 		no annotation 5 GLY A  31
PRO A  60
ASN A  96
LEU A  27
PHE A  80
 None
None
NAP  A1001 (-3.4A)
None
None
 1.21A 2zzmA-5ovlA:
5.1		 2zzmA-5ovlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A

(Pyrococcus
abyssi) 		no annotation 8 ARG A 133
PHE A 191
GLY A 193
PRO A 196
ILE A 214
ASN A 215
ASP A 243
VAL A 244
 G  C  37 ( 4.0A)
MTA  A 401 (-4.4A)
MTA  A 401 (-3.6A)
None
MTA  A 401 (-3.7A)
None
MTA  A 401 (-3.3A)
MTA  A 401 (-3.8A)
 0.63A 2zzmA-5wt3A:
28.0		 2zzmA-5wt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 5 LEU A 306
PHE A 228
GLY A  48
PRO A 250
VAL A 205
 None
 1.14A 2zzmA-5wugA:
undetectable		 2zzmA-5wugA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B

(Pyrococcus
abyssi) 		PF02475
(Met_10) 		9 TYR A 164
LEU A 169
PHE A 190
GLY A 192
PRO A 195
ASN A 213
ASP A 238
LEU A 253
PHE A 260
 None
 0.70A 2zzmA-5yacA:
31.0		 2zzmA-5yacA:
42.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1

(Mus musculus) 		no annotation 5 TYR A 205
ILE A 165
ASP A 169
LEU A 201
PHE A 197
 None
 1.21A 2zzmA-6brkA:
undetectable		 2zzmA-6brkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
COMPONENT RRP40

(Homo sapiens) 		no annotation 5 PHE G 129
ASP G 161
VAL G 157
LEU G 141
PHE G 146
 None
 1.14A 2zzmA-6d6qG:
undetectable		 2zzmA-6d6qG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE

(Paenibacillus
sp. YM1) 		no annotation 5 TYR A 286
GLY A 217
ILE A 163
VAL A 268
PHE A 235
 None
 1.04A 2zzmA-6gh2A:
undetectable		 2zzmA-6gh2A:
undetectable