SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZZM_A_SAMA401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aow ANNEXIN IV

(Bos taurus) 		PF00191
(Annexin) 		5 LEU A 193
GLY A 157
ILE A 123
ASN A 124
ASP A  90
 None
 1.15A 2zzmA-1aowA:
0.0		 2zzmA-1aowA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE

(Rattus
norvegicus) 		PF00106
(adh_short) 		5 ARG A  29
GLY A  23
ILE A 151
VAL A  87
LEU A  30
 None
 1.18A 2zzmA-1e6wA:
6.6		 2zzmA-1e6wA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Thermotoga
maritima) 		PF01380
(SIS) 		5 PHE A  45
GLY A  47
PRO A  74
ILE A 121
PHE A  62
 None
 1.03A 2zzmA-1j5xA:
2.1		 2zzmA-1j5xA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1my6 IRON (III)
SUPEROXIDE DISMUTASE

(Thermosynechococcus
elongatus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 TYR A  17
GLY A  91
ASN A 184
LEU A  86
PHE A  82
 None
 1.21A 2zzmA-1my6A:
0.0		 2zzmA-1my6A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7r HYALURONIDASE

(Streptococcus
pneumoniae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 LEU A 813
PHE A 679
GLY A 794
LEU A 797
PHE A 594
 None
 1.24A 2zzmA-1n7rA:
0.0		 2zzmA-1n7rA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oll NK RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A 102
GLY A 168
PRO A 100
VAL A  92
PHE A  13
 None
 1.22A 2zzmA-1ollA:
undetectable		 2zzmA-1ollA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p6f NATURAL CYTOTOXICITY
TRIGGERING RECEPTOR
1

(Homo sapiens) 		no annotation 5 LEU A 105
GLY A 171
PRO A 103
VAL A  95
PHE A  16
 None
 1.20A 2zzmA-1p6fA:
0.0		 2zzmA-1p6fA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhl PROTEIN (CELL
DIVISION PROTEIN
MUKB)

(Escherichia
coli) 		PF04310
(MukB) 		5 ARG A   8
PHE A   7
GLY A   5
ILE A 183
ASN A  94
 None
 1.05A 2zzmA-1qhlA:
0.0		 2zzmA-1qhlA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkx CDP-GLUCOSE-4,6-DEHY
DRATASE

(Yersinia
pseudotuberculosis) 		PF16363
(GDP_Man_Dehyd) 		5 ARG A 192
PHE A 262
GLY A 194
PRO A 231
ILE A 130
 None
None
NAD  A 360 (-3.5A)
None
NAD  A 360 (-4.8A)
 0.87A 2zzmA-1rkxA:
4.5		 2zzmA-1rkxA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sji CALSEQUESTRIN,
CARDIAC MUSCLE
ISOFORM

(Canis lupus) 		PF01216
(Calsequestrin) 		5 TYR A 160
PHE A 176
GLY A 150
VAL A 222
PHE A 170
 None
 1.19A 2zzmA-1sjiA:
undetectable		 2zzmA-1sjiA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0u HYPOTHETICAL
METHYLMALONYL-COA
DECARBOXYLASE ALPHA
SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01039
(Carboxyl_trans) 		5 PHE A 338
PRO A 289
ILE A 342
ASN A 333
VAL A 374
 None
 1.06A 2zzmA-1x0uA:
undetectable		 2zzmA-1x0uA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp8 RECA PROTEIN

(Deinococcus
radiodurans) 		PF00154
(RecA) 		5 PHE A 203
PRO A  69
ILE A 204
VAL A 155
LEU A 227
 None
 1.19A 2zzmA-1xp8A:
1.3		 2zzmA-1xp8A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d) 		5 LEU A 137
PHE A 315
GLY A 284
ILE A 237
PHE A 114
 None
 1.18A 2zzmA-2amcA:
undetectable		 2zzmA-2amcA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e2n HEXOKINASE

(Sulfurisphaera
tokodaii) 		PF01869
(BcrAD_BadFG) 		5 ARG A 153
LEU A 181
ILE A 219
ASP A 218
VAL A 215
 None
 1.16A 2zzmA-2e2nA:
undetectable		 2zzmA-2e2nA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES

(Escherichia
coli) 		PF07995
(GSDH) 		5 GLY A 130
PRO A 196
VAL A  69
LEU A 140
PHE A 134
 None
 1.06A 2zzmA-2g8sA:
undetectable		 2zzmA-2g8sA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Aquifex
aeolicus) 		PF03331
(LpxC) 		5 TYR A  23
GLY A  17
ILE A  74
ASN A  99
LEU A  26
 None
 1.23A 2zzmA-2go4A:
undetectable		 2zzmA-2go4A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2y FUSION PROTEIN
CONSISTS OF
IMMUNOGLOBULIN
G-BINDING PROTEIN G
AND SPLICING FACTOR,
ARGININE/SERINE-RICH
3

(Streptococcus
sp. 'group G';
Homo sapiens) 		PF00076
(RRM_1)
PF01378
(IgG_binding_B) 		5 ARG A  92
TYR A  96
PHE A  94
GLY A  98
VAL A 115
 None
 1.11A 2zzmA-2i2yA:
2.9		 2zzmA-2i2yA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is5 HYPOTHETICAL PROTEIN

(Neisseria
meningitidis) 		PF05838
(Glyco_hydro_108)
PF09374
(PG_binding_3) 		5 GLY A  18
ILE A  34
VAL A  86
LEU A  13
PHE A  82
 None
 1.13A 2zzmA-2is5A:
undetectable		 2zzmA-2is5A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mev MENGO VIRUS COAT
PROTEIN (SUBUNIT
VP2)
MENGO VIRUS COAT
PROTEIN (SUBUNIT
VP3)

(Cardiovirus A;
Cardiovirus A) 		PF00073
(Rhv)
PF00073
(Rhv) 		5 ARG 2 101
LEU 2 248
GLY 3 132
PRO 3 130
LEU 2 100
 None
 1.20A 2zzmA-2mev2:
undetectable		 2zzmA-2mev2:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		5 ARG A 487
PHE A 486
GLY A 151
ILE A 154
PHE A 453
 None
 1.13A 2zzmA-2okxA:
undetectable		 2zzmA-2okxA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qne PUTATIVE
METHYLTRANSFERASE

(Desulfitobacterium
hafniense) 		PF06253
(MTTB) 		5 LEU A 181
GLY A 163
ILE A 225
LEU A  72
PHE A  70
 None
EDO  A 477 ( 4.6A)
None
None
None
 0.97A 2zzmA-2qneA:
undetectable		 2zzmA-2qneA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		5 GLY A 807
PRO A 462
ILE A 782
VAL A 800
LEU A 572
 None
 1.22A 2zzmA-2vz9A:
undetectable		 2zzmA-2vz9A:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7q OUTER-MEMBRANE
LIPOPROTEIN CARRIER
PROTEIN

(Pseudomonas
aeruginosa) 		PF03548
(LolA) 		5 PHE A  67
GLY A  65
ILE A  80
ASN A  82
LEU A 111
 None
 0.99A 2zzmA-2w7qA:
undetectable		 2zzmA-2w7qA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz8 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN LF

(Drosophila
melanogaster) 		no annotation 5 PHE A 332
GLY A 305
ILE A 309
ASN A 308
PHE A 263
 None
 1.23A 2zzmA-2xz8A:
undetectable		 2zzmA-2xz8A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK

([Ruminococcus]
gnavus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		5 ARG A 194
LEU A 304
GLY A 553
ASN A 204
PHE A 257
 None
 1.20A 2zzmA-2yfnA:
undetectable		 2zzmA-2yfnA:
17.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3a27 UNCHARACTERIZED
PROTEIN MJ1557

(Methanocaldococcus
jannaschii) 		PF02475
(Met_10) 		5 PHE A 104
GLY A 106
ASN A 129
ASP A 154
PHE A 178
 SAM  A 250 (-4.7A)
SAM  A 250 (-3.6A)
None
SAM  A 250 (-3.2A)
SAM  A 250 (-4.6A)
 0.54A 2zzmA-3a27A:
26.0		 2zzmA-3a27A:
31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ay0 UNCHARACTERIZED
PROTEIN MJ0883

(Methanocaldococcus
jannaschii) 		PF02475
(Met_10) 		11 TYR A 177
LEU A 182
PHE A 203
GLY A 205
PRO A 208
ILE A 224
ASN A 225
ASP A 251
VAL A 252
LEU A 266
PHE A 273
 ADN  A 401 (-4.3A)
None
ADN  A 401 (-4.9A)
ADN  A 401 ( 4.0A)
None
ADN  A 401 (-3.7A)
ADN  A 401 (-4.9A)
ADN  A 401 (-3.8A)
ADN  A 401 (-3.9A)
ADN  A 401 ( 4.7A)
ADN  A 401 (-4.6A)
 0.51A 2zzmA-3ay0A:
36.3		 2zzmA-3ay0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 PHE A3191
PRO A3057
ILE A3192
VAL A3143
LEU A3215
 None
 1.22A 2zzmA-3cmtA:
undetectable		 2zzmA-3cmtA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 PHE A2191
PRO A2057
ILE A2192
VAL A2143
LEU A2215
 None
 1.24A 2zzmA-3cmvA:
undetectable		 2zzmA-3cmvA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dli METHYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF13489
(Methyltransf_23) 		5 PHE A 351
GLY A 292
ILE A 312
ASN A 313
ASP A 330
 None
 0.72A 2zzmA-3dliA:
13.3		 2zzmA-3dliA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmy PROTEIN FDRA

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 LEU A 153
PRO A 173
ILE A 199
VAL A 259
LEU A 231
 None
 1.18A 2zzmA-3dmyA:
undetectable		 2zzmA-3dmyA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0s UNCHARACTERIZED
PROTEIN

(Chlorobaculum
tepidum) 		PF05235
(CHAD) 		5 ARG A 267
LEU A 229
ILE A 412
ASP A 413
LEU A 268
 None
 1.17A 2zzmA-3e0sA:
undetectable		 2zzmA-3e0sA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1

(Homo sapiens) 		PF00616
(RasGAP) 		5 LEU A1030
GLY A1159
VAL A1153
LEU A1191
PHE A1265
 None
 1.15A 2zzmA-3fayA:
undetectable		 2zzmA-3fayA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5a FMN
ADENYLYLTRANSFERASE

([Candida]
glabrata) 		PF01507
(PAPS_reduct) 		5 LEU A 205
GLY A 287
ASN A 232
LEU A 223
PHE A 114
 None
None
None
APC  A 305 (-4.4A)
None
 1.16A 2zzmA-3g5aA:
undetectable		 2zzmA-3g5aA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7u CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Escherichia
coli) 		PF00145
(DNA_methylase) 		5 PHE A   7
GLY A   9
ILE A  30
ASP A  51
VAL A  52
 None
 0.71A 2zzmA-3g7uA:
8.5		 2zzmA-3g7uA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkb PUTATIVE ENOYL-COA
HYDRATASE

(Streptomyces
avermitilis) 		PF00378
(ECH_1) 		5 LEU A 268
GLY A 113
VAL A 109
LEU A  65
PHE A 122
 None
 1.02A 2zzmA-3gkbA:
undetectable		 2zzmA-3gkbA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN HEAVY CHAIN
ISOFORM A

(Doryteuthis
pealeii) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF02736
(Myosin_N) 		5 LEU A 390
ILE A 302
ASN A 301
VAL A 308
LEU A 361
 None
 0.94A 2zzmA-3i5gA:
undetectable		 2zzmA-3i5gA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifq PLAKOGLOBIN
E-CADHERIN

(Homo sapiens;
Mus musculus) 		PF00514
(Arm)
PF01049
(Cadherin_C) 		5 GLY A 640
ILE C 657
ASN C 660
VAL A 648
LEU A 634
 None
 1.14A 2zzmA-3ifqA:
undetectable		 2zzmA-3ifqA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		5 TYR W 556
PHE W 554
GLY W 520
VAL W 552
LEU W 564
 None
 0.96A 2zzmA-3iylW:
8.6		 2zzmA-3iylW:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcc PUTATIVE METHYL
CHLORIDE TRANSFERASE

(Arabidopsis
thaliana) 		PF05724
(TPMT) 		5 PHE A 141
GLY A  76
ILE A  96
ASP A 123
VAL A 124
 SAH  A 300 (-4.6A)
SAH  A 300 (-3.5A)
SAH  A 300 (-4.2A)
SAH  A 300 (-3.8A)
SAH  A 300 (-4.1A)
 0.79A 2zzmA-3lccA:
14.4		 2zzmA-3lccA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mae 2-OXOISOVALERATE
DEHYDROGENASE E2
COMPONENT,
DIHYDROLIPOAMIDE
ACETYLTRANSFERASE

(Listeria
monocytogenes) 		PF00198
(2-oxoacid_dh) 		5 PHE A 331
ILE A 277
ASN A 278
VAL A 252
PHE A 397
 None
 1.21A 2zzmA-3maeA:
undetectable		 2zzmA-3maeA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		5 TYR A  82
GLY A  94
ILE A 263
LEU A  84
PHE A 423
 None
 1.24A 2zzmA-3mpnA:
undetectable		 2zzmA-3mpnA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0v FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Pseudomonas
putida) 		PF00551
(Formyl_trans_N) 		5 ARG A 109
TYR A 108
ILE A  94
VAL A  92
LEU A 115
 None
 1.19A 2zzmA-3n0vA:
4.9		 2zzmA-3n0vA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nip 3-GUANIDINOPROPIONAS
E

(Pseudomonas
aeruginosa) 		PF00491
(Arginase) 		5 LEU A   9
PHE A  23
GLY A  86
ILE A  40
VAL A 122
 None
 1.23A 2zzmA-3nipA:
undetectable		 2zzmA-3nipA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqp SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 LEU A 507
GLY A  76
ILE A  79
ASN A 344
LEU A  96
 None
None
EDO  A1004 ( 3.8A)
None
None
 1.18A 2zzmA-3nqpA:
undetectable		 2zzmA-3nqpA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		5 ARG A 254
LEU A 735
PHE A 221
PRO A  27
ILE A 210
 None
 1.12A 2zzmA-3pieA:
2.8		 2zzmA-3pieA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qiv SHORT-CHAIN
DEHYDROGENASE OR
3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		5 GLY A  14
ILE A  37
ASN A  38
ASP A  62
VAL A  63
 None
 0.89A 2zzmA-3qivA:
7.3		 2zzmA-3qivA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3so2 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chlorella
variabilis) 		PF00692
(dUTPase) 		5 GLY A  91
ASP A 108
VAL A 104
LEU A  94
PHE A 102
 None
 1.22A 2zzmA-3so2A:
undetectable		 2zzmA-3so2A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 GLY A 416
PRO A 419
ASN A 452
ASP A 477
LEU A 500
 None
 1.22A 2zzmA-3ua4A:
7.8		 2zzmA-3ua4A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvd AMINO ACID ABC
TRANSPORTER, BINDING
PROTEIN

(Thermus
thermophilus) 		PF00497
(SBP_bac_3) 		5 LEU A  34
PHE A  37
ASP A 232
VAL A 233
LEU A  41
 None
 1.21A 2zzmA-3vvdA:
undetectable		 2zzmA-3vvdA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		5 TYR A2253
LEU A1949
PHE A1992
ILE A1960
PHE A2080
 None
 1.23A 2zzmA-4asiA:
undetectable		 2zzmA-4asiA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmr RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus cereus) 		PF00268
(Ribonuc_red_sm) 		5 TYR A 171
LEU A 249
GLY A 168
ILE A 191
LEU A 173
 None
 1.17A 2zzmA-4bmrA:
undetectable		 2zzmA-4bmrA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 PHE A 124
GLY A 158
ILE A 285
ASP A 344
LEU A 151
 None
 1.06A 2zzmA-4bziA:
undetectable		 2zzmA-4bziA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN

(Escherichia
coli) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 ARG A  79
GLY A  71
ILE A  77
VAL A  55
PHE A  51
 None
 1.07A 2zzmA-4c7oA:
undetectable		 2zzmA-4c7oA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex4 MALATE SYNTHASE G

(Mycobacterium
leprae) 		PF01274
(Malate_synthase) 		5 LEU A 381
GLY A 426
PRO A 428
VAL A  39
LEU A 375
 None
 1.21A 2zzmA-4ex4A:
undetectable		 2zzmA-4ex4A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 HSL7 PROTEIN

(Xenopus laevis) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 GLY A 363
PRO A 366
ASN A 390
ASP A 415
LEU A 432
 SAH  A 701 ( 4.1A)
None
None
SAH  A 701 (-2.8A)
SAH  A 701 (-4.5A)
 0.92A 2zzmA-4g56A:
8.9		 2zzmA-4g56A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Homo sapiens) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 GLY A 367
PRO A 370
ASN A 394
ASP A 419
LEU A 436
 0XU  A 701 ( 3.7A)
0XU  A 701 (-4.2A)
None
0XU  A 701 (-2.9A)
None
 0.87A 2zzmA-4gqbA:
9.4		 2zzmA-4gqbA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0u THYMIDYLATE SYNTHASE

(Corynebacterium
glutamicum) 		PF00303
(Thymidylat_synt) 		5 LEU A 162
ASN A 236
VAL A 251
LEU A 186
PHE A  55
 None
 1.14A 2zzmA-4h0uA:
undetectable		 2zzmA-4h0uA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		5 LEU A 240
GLY A 196
PRO A 199
ILE A 146
LEU A 227
 None
 1.18A 2zzmA-4idmA:
4.3		 2zzmA-4idmA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imd N-ACETYLNEURAMINATE
LYASE

(Pasteurella
multocida) 		PF00701
(DHDPS) 		5 PHE A 109
GLY A 143
ILE A 138
VAL A 106
PHE A  52
 None
 1.23A 2zzmA-4imdA:
undetectable		 2zzmA-4imdA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Paracoccus
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 166
ILE A 174
VAL A 177
LEU A 218
PHE A 216
 None
 1.11A 2zzmA-4izgA:
undetectable		 2zzmA-4izgA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 PHE A 114
GLY A 117
ASN A  94
VAL A  46
LEU A 109
 None
 1.05A 2zzmA-4j0mA:
undetectable		 2zzmA-4j0mA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcn GLUTAMYL
ENDOPEPTIDASE

(Staphylococcus
epidermidis) 		PF13365
(Trypsin_2) 		5 GLY A 124
ILE A  93
ASN A 128
VAL A 118
LEU A 163
 None
 1.21A 2zzmA-4jcnA:
undetectable		 2zzmA-4jcnA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 HEAVY
CHAIN
MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 LIGHT
CHAIN

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 PHE L  98
GLY L 100
VAL H  37
LEU L  89
PHE H  96
 None
 1.20A 2zzmA-4jo2L:
undetectable		 2zzmA-4jo2L:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 GLY A 551
ILE A 555
ASN A 554
VAL A 629
LEU A 617
 None
 1.06A 2zzmA-4kxbA:
undetectable		 2zzmA-4kxbA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ooq DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Arabidopsis
thaliana) 		PF00692
(dUTPase) 		5 ARG A  88
ILE A  69
VAL A  61
LEU A  91
PHE A 124
 None
 1.16A 2zzmA-4ooqA:
undetectable		 2zzmA-4ooqA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4owt INTEGRATOR COMPLEX
SUBUNIT 3
SOSS COMPLEX SUBUNIT
C

(Homo sapiens;
Homo sapiens) 		PF10189
(Ints3)
PF15925
(SOSSC) 		5 ARG A 263
TYR C  82
LEU C 101
ASN A 260
VAL A 233
 None
 1.09A 2zzmA-4owtA:
undetectable		 2zzmA-4owtA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlp ALANINE AND PROLINE
RICH PROTEIN,
TUBERCULOSIS
NECROTIZING TOXIN
(TNT)

(Mycobacterium
tuberculosis) 		PF14021
(TNT) 		5 ARG B 713
GLY B 813
ASN B 726
VAL B 784
PHE B 696
 None
 1.17A 2zzmA-4qlpB:
undetectable		 2zzmA-4qlpB:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlp ALANINE AND PROLINE
RICH PROTEIN,
TUBERCULOSIS
NECROTIZING TOXIN
(TNT)

(Mycobacterium
tuberculosis) 		PF14021
(TNT) 		5 ARG B 713
PRO B 812
ASN B 726
VAL B 784
PHE B 696
 None
 1.15A 2zzmA-4qlpB:
undetectable		 2zzmA-4qlpB:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB

(Drosophila
melanogaster) 		PF10613
(Lig_chan-Glu_bd) 		5 GLY A  18
PRO A  20
ASN A 180
ASP A  65
VAL A  63
 None
 1.23A 2zzmA-4wxjA:
undetectable		 2zzmA-4wxjA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxc FLAGELLAR ASSEMBLY
PROTEIN H,ENDOLYSIN

(Escherichia
virus T4;
Salmonella
enterica) 		PF00959
(Phage_lysozyme) 		5 LEU A  36
PHE A  88
ASP A  93
VAL A  92
PHE A  25
 None
 1.22A 2zzmA-4yxcA:
undetectable		 2zzmA-4yxcA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aor DOSAGE COMPENSATION
REGULATOR

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		5 LEU A 859
GLY A1007
VAL A 999
LEU A 874
PHE A 878
 None
 1.09A 2zzmA-5aorA:
3.7		 2zzmA-5aorA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd7 MATERNAL EFFECT
PROTEIN OSKAR

(Drosophila
melanogaster) 		PF12872
(OST-HTH) 		5 PHE A 189
ASN A 187
VAL A 160
LEU A 191
PHE A 198
 None
 1.18A 2zzmA-5cd7A:
undetectable		 2zzmA-5cd7A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		5 PRO A 132
ILE A 225
ASN A 176
VAL A 216
PHE A 180
 None
 1.14A 2zzmA-5d0fA:
undetectable		 2zzmA-5d0fA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dhx ANTI-REV ANTIBODY
FAB SINGLE-CHAIN
VARIABLE FRAGMENT,
LIGHT CHAIN,ANTI-REV
ANTIBODY FAB
SINGLE-CHAIN
VARIABLE FRAGMENT,
HEAVY CHAIN

(Oryctolagus
cuniculus) 		PF07686
(V-set) 		5 PHE B 101
GLY B 103
VAL B 147
LEU B  89
PHE B 214
 None
 1.23A 2zzmA-5dhxB:
undetectable		 2zzmA-5dhxB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia annua) 		PF00724
(Oxidored_FMN) 		5 LEU A 272
ILE A  62
VAL A 159
LEU A 187
PHE A 212
 None
 1.13A 2zzmA-5dxxA:
undetectable		 2zzmA-5dxxA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e72 N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE

(Thermococcus
kodakarensis) 		PF01170
(UPF0020)
PF02926
(THUMP) 		5 LEU A 165
PHE A 187
GLY A 189
ILE A 209
ASP A 235
 None
SAM  A 400 (-4.7A)
SAM  A 400 (-3.3A)
SAM  A 400 (-3.9A)
SAM  A 400 (-3.4A)
 0.87A 2zzmA-5e72A:
16.8		 2zzmA-5e72A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5egn ESTERASE

(uncultured
bacterium) 		PF12697
(Abhydrolase_6) 		5 LEU A 199
GLY A  96
ASN A  92
LEU A 122
PHE A 191
 None
 1.03A 2zzmA-5egnA:
undetectable		 2zzmA-5egnA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffj ENDONUCLEASE AND
METHYLASE LLAGI

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII) 		5 TYR A1403
LEU A1431
GLY A1441
ILE A1360
LEU A1408
 None
 1.22A 2zzmA-5ffjA:
10.9		 2zzmA-5ffjA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fod LEUCYL-TRNA
SYNTHETASE

(Plasmodium
falciparum) 		no annotation 5 PHE A 391
GLY A 393
ILE A 390
VAL A 283
PHE A 289
 None
 1.19A 2zzmA-5fodA:
undetectable		 2zzmA-5fodA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghe PESTICIDAL CRYSTAL
PROTEIN CRY6AA

(Bacillus
thuringiensis) 		no annotation 5 PHE A 186
GLY A 189
ILE A 200
ASN A 199
ASP A  90
 None
 1.03A 2zzmA-5gheA:
undetectable		 2zzmA-5gheA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5has SEC7

(Thielavia
terrestris) 		PF12783
(Sec7_N)
PF16213
(DCB) 		5 LEU A 169
PHE A 177
ILE A 355
ASN A 352
VAL A 357
 None
 1.06A 2zzmA-5hasA:
undetectable		 2zzmA-5hasA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvm ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Aspergillus
fumigatus) 		PF00982
(Glyco_transf_20) 		5 LEU A 154
GLY A 175
PRO A 158
LEU A  16
PHE A  55
 None
 1.15A 2zzmA-5hvmA:
2.3		 2zzmA-5hvmA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icq METHYLOCYSTIS PARVUS
OBBP MBNE

(Methylocystis
parvus) 		PF00496
(SBP_bac_5) 		6 ARG A 339
PHE A 342
PRO A 406
VAL A 471
LEU A 338
PHE A 444
 None
 1.39A 2zzmA-5icqA:
undetectable		 2zzmA-5icqA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcn OS09G0567300 PROTEIN

(Oryza sativa) 		PF07992
(Pyr_redox_2) 		5 TYR A 174
LEU A 203
GLY A 172
VAL A 221
PHE A 353
 NAD  A 501 (-3.6A)
None
NAD  A 501 ( 4.5A)
None
None
 1.17A 2zzmA-5jcnA:
undetectable		 2zzmA-5jcnA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy1 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Paraburkholderia
xenovorans) 		PF13561
(adh_short_C2) 		5 GLY A  15
ILE A  38
ASN A  39
ASP A  63
VAL A  64
 NAD  A 301 ( 4.2A)
NAD  A 301 (-3.7A)
None
NAD  A 301 (-3.8A)
NAD  A 301 (-3.6A)
 0.86A 2zzmA-5jy1A:
6.8		 2zzmA-5jy1A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		5 LEU A 242
PHE A 309
GLY A 319
ILE A 312
PHE A 270
 None
None
None
CU  A 808 ( 4.9A)
None
 1.10A 2zzmA-5k8dA:
undetectable		 2zzmA-5k8dA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA

(Bacillus
thuringiensis) 		no annotation 5 PHE A 186
GLY A 189
ILE A 200
ASN A 199
ASP A  90
 None
 0.88A 2zzmA-5kucA:
undetectable		 2zzmA-5kucA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3r SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN,
CHLOROPLASTIC
CELL DIVISION
PROTEIN FTSY
HOMOLOG,
CHLOROPLASTIC

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF00448
(SRP54)
PF02881
(SRP54_N) 		5 LEU A 115
PHE B 109
VAL B 144
LEU B 104
PHE B 365
 None
 1.23A 2zzmA-5l3rA:
undetectable		 2zzmA-5l3rA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lwe C-C CHEMOKINE
RECEPTOR TYPE 9

(Homo sapiens) 		PF00001
(7tm_1) 		5 LEU A  87
GLY A  65
VAL A  58
LEU A 312
PHE A 308
 79K  A 401 (-4.3A)
OLA  A 412 ( 4.1A)
None
CLR  A 417 ( 4.7A)
OLA  A 402 (-4.1A)
 1.01A 2zzmA-5lweA:
undetectable		 2zzmA-5lweA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m11 IMMUNOREACTIVE 84KD
ANTIGEN PG93

(Porphyromonas
gingivalis) 		no annotation 5 ARG A 424
LEU A 457
ASN A 389
VAL A 362
PHE A 416
 None
 1.05A 2zzmA-5m11A:
undetectable		 2zzmA-5m11A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5od2 BIFUNCTIONAL
ADP-SPECIFIC
GLUCOKINASE/PHOSPHOF
RUCTOKINASE

(Methanocaldococcus
jannaschii) 		no annotation 5 LEU A 354
ILE A 309
ASN A 305
LEU A 335
PHE A 339
 None
 1.23A 2zzmA-5od2A:
3.7		 2zzmA-5od2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oet GLUTATHIONE
SYNTHETASE-LIKE
EFFECTOR 30
(GPA-GSS30-APO)

(Globodera
pallida) 		no annotation 5 PHE B 101
PRO B 473
ASP B 106
VAL B 105
LEU B 524
 None
 1.14A 2zzmA-5oetB:
undetectable		 2zzmA-5oetB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovl 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG

(Mycolicibacterium
smegmatis) 		no annotation 5 GLY A  31
PRO A  60
ASN A  96
LEU A  27
PHE A  80
 None
None
NAP  A1001 (-3.4A)
None
None
 1.21A 2zzmA-5ovlA:
5.1		 2zzmA-5ovlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A

(Pyrococcus
abyssi) 		no annotation 8 ARG A 133
PHE A 191
GLY A 193
PRO A 196
ILE A 214
ASN A 215
ASP A 243
VAL A 244
 G  C  37 ( 4.0A)
MTA  A 401 (-4.4A)
MTA  A 401 (-3.6A)
None
MTA  A 401 (-3.7A)
None
MTA  A 401 (-3.3A)
MTA  A 401 (-3.8A)
 0.63A 2zzmA-5wt3A:
28.0		 2zzmA-5wt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 5 LEU A 306
PHE A 228
GLY A  48
PRO A 250
VAL A 205
 None
 1.14A 2zzmA-5wugA:
undetectable		 2zzmA-5wugA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B

(Pyrococcus
abyssi) 		PF02475
(Met_10) 		9 TYR A 164
LEU A 169
PHE A 190
GLY A 192
PRO A 195
ASN A 213
ASP A 238
LEU A 253
PHE A 260
 None
 0.70A 2zzmA-5yacA:
31.0		 2zzmA-5yacA:
42.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1

(Mus musculus) 		no annotation 5 TYR A 205
ILE A 165
ASP A 169
LEU A 201
PHE A 197
 None
 1.21A 2zzmA-6brkA:
undetectable		 2zzmA-6brkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
COMPONENT RRP40

(Homo sapiens) 		no annotation 5 PHE G 129
ASP G 161
VAL G 157
LEU G 141
PHE G 146
 None
 1.14A 2zzmA-6d6qG:
undetectable		 2zzmA-6d6qG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE

(Paenibacillus
sp. YM1) 		no annotation 5 TYR A 286
GLY A 217
ILE A 163
VAL A 268
PHE A 235
 None
 1.04A 2zzmA-6gh2A:
undetectable		 2zzmA-6gh2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3b PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermotoga
maritima) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 ARG A 190
ASP A 362
ASN A 368
 None
 0.85A 2zzmA-1b3bA:
4.4		 2zzmA-1b3bA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Pseudomonas
fluorescens) 		PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5) 		3 ARG A  83
ASP A 138
ASN A  55
 None
 0.86A 2zzmA-1cjxA:
undetectable		 2zzmA-1cjxA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e32 P97

(Mus musculus) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2) 		3 ARG A  95
ASP A 204
ASN A  90
 None
 0.79A 2zzmA-1e32A:
undetectable		 2zzmA-1e32A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH

(Escherichia
coli) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		3 ARG A 162
ASP A 101
ASN A 156
 None
 0.84A 2zzmA-1gz0A:
undetectable		 2zzmA-1gz0A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03372
(Exo_endo_phos) 		3 ARG A 744
ASP A 713
ASN A 706
 2IP  A 302 (-2.8A)
None
None
 0.58A 2zzmA-1i9zA:
1.8		 2zzmA-1i9zA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5o CPI-17

(Sus scrofa) 		PF05361
(PP1_inhibitor) 		3 ARG A  25
ASP A  17
ASN A  72
 None
 0.89A 2zzmA-1k5oA:
undetectable		 2zzmA-1k5oA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lar PROTEIN (LAR)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A1365
ASP A1407
ASN A1349
 None
 0.79A 2zzmA-1larA:
undetectable		 2zzmA-1larA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 ARG A 215
ASP A 357
ASN A 362
 None
 0.64A 2zzmA-1llaA:
undetectable		 2zzmA-1llaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 ARG A 526
ASP A  78
ASN A 341
 None
 0.85A 2zzmA-1mroA:
undetectable		 2zzmA-1mroA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 ARG A 278
ASP A 352
ASN A 404
 None
 0.85A 2zzmA-1qf7A:
undetectable		 2zzmA-1qf7A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjm LACTOFERRIN

(Equus caballus) 		PF00405
(Transferrin) 		3 ARG A 531
ASP A 563
ASN A 556
 None
 0.89A 2zzmA-1qjmA:
undetectable		 2zzmA-1qjmA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpm RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
MU

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A 939
ASP A 981
ASN A 923
 None
 0.88A 2zzmA-1rpmA:
undetectable		 2zzmA-1rpmA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1v SH3 DOMAIN-BINDING
GLUTAMIC ACID-RICH
PROTEIN-LIKE 3

(Mus musculus) 		PF04908
(SH3BGR) 		3 ARG A  51
ASP A  39
ASN A  44
 None
 0.87A 2zzmA-1t1vA:
undetectable		 2zzmA-1t1vA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te2 2-DEOXYGLUCOSE-6-P
PHOSPHATASE

(Escherichia
coli) 		PF13419
(HAD_2) 		3 ARG A 201
ASP A 173
ASN A 176
 None
CA  A 702 (-2.9A)
None
 0.67A 2zzmA-1te2A:
2.1		 2zzmA-1te2A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1

(Rattus
norvegicus) 		PF00996
(GDI) 		3 ARG A  40
ASP A 433
ASN A  46
 None
 0.60A 2zzmA-1vg0A:
undetectable		 2zzmA-1vg0A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1n 4-ALPHA-GLUCANOTRANS
FERASE

(Solanum
tuberosum) 		PF02446
(Glyco_hydro_77) 		3 ARG A 194
ASP A  88
ASN A 256
 GOL  A1006 (-3.7A)
None
None
 0.60A 2zzmA-1x1nA:
undetectable		 2zzmA-1x1nA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A 959
ASP A1020
ASN A 943
 None
 0.83A 2zzmA-1yguA:
undetectable		 2zzmA-1yguA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhn RAS-RELATED PROTEIN
RAB-7

(Homo sapiens) 		PF00071
(Ras) 		3 ARG A 103
ASP A 114
ASN A 147
 None
 0.86A 2zzmA-1yhnA:
undetectable		 2zzmA-1yhnA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3o TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		3 ARG A 286
ASP A 334
ASN A 270
 None
 0.79A 2zzmA-2b3oA:
undetectable		 2zzmA-2b3oA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b49 PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 3

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A 829
ASP A 834
ASN A 712
 None
 0.82A 2zzmA-2b49A:
undetectable		 2zzmA-2b49A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT

(Hyphomicrobium
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		3 ARG A 109
ASP A 330
ASN A 394
 PQQ  A 601 (-3.2A)
None
PQQ  A 601 (-3.5A)
 0.83A 2zzmA-2d0vA:
undetectable		 2zzmA-2d0vA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7d UVRABC SYSTEM
PROTEIN B

(Bacillus
subtilis) 		PF00271
(Helicase_C)
PF02151
(UVR)
PF04851
(ResIII)
PF12344
(UvrB) 		3 ARG A 183
ASP A 198
ASN A 170
 None
 0.89A 2zzmA-2d7dA:
3.8		 2zzmA-2d7dA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fez PROBABLE REGULATORY
PROTEIN EMBR

(Mycobacterium
tuberculosis) 		PF00486
(Trans_reg_C)
PF00498
(FHA)
PF03704
(BTAD) 		3 ARG A 370
ASP A 343
ASN A 348
 None
 0.87A 2zzmA-2fezA:
undetectable		 2zzmA-2fezA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2foi ENOYL-ACYL CARRIER
REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		3 ARG A 318
ASP A 168
ASN A 218
 None
NAD  A 450 (-3.8A)
NAD  A 450 (-4.1A)
 0.73A 2zzmA-2foiA:
5.1		 2zzmA-2foiA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjt RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE PTPRO

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A 978
ASP A1020
ASN A 962
 None
 0.77A 2zzmA-2gjtA:
undetectable		 2zzmA-2gjtA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A1743
ASP A1785
ASN A1727
 None
MG  A 304 ( 3.8A)
None
 0.82A 2zzmA-2h03A:
undetectable		 2zzmA-2h03A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A 750
ASP A 793
ASN A 734
 None
 0.83A 2zzmA-2i1yA:
undetectable		 2zzmA-2i1yA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A 467
ASP A 509
ASN A 451
 None
 0.76A 2zzmA-2jjdA:
undetectable		 2zzmA-2jjdA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A 890
ASP A 934
ASN A 874
 None
 0.86A 2zzmA-2nlkA:
undetectable		 2zzmA-2nlkA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nv5 PTPRD, PHOSPHATASE

(Rattus
norvegicus) 		PF00102
(Y_phosphatase) 		3 ARG A1267
ASP A1309
ASN A1251
 None
 0.85A 2zzmA-2nv5A:
undetectable		 2zzmA-2nv5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A 950
ASP A 992
ASN A 934
 None
 0.81A 2zzmA-2ooqA:
undetectable		 2zzmA-2ooqA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A 343
ASP A 385
ASN A 327
 None
 0.85A 2zzmA-2pa5A:
undetectable		 2zzmA-2pa5A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A 786
ASP A 829
ASN A 770
 None
 0.71A 2zzmA-2qepA:
undetectable		 2zzmA-2qepA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		3 ARG A 411
ASP A 106
ASN A 268
 None
 0.54A 2zzmA-2r6fA:
undetectable		 2zzmA-2r6fA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvy PROTEIN B15

(Vaccinia virus) 		PF06227
(Poxvirus) 		3 ARG A 146
ASP A  24
ASN A 142
 None
 0.88A 2zzmA-2vvyA:
undetectable		 2zzmA-2vvyA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wf7 BETA-PHOSPHOGLUCOMUT
ASE

(Lactococcus
lactis) 		PF13419
(HAD_2) 		3 ARG A  38
ASP A 170
ASN A  41
 None
MG  A1220 (-2.5A)
None
 0.84A 2zzmA-2wf7A:
undetectable		 2zzmA-2wf7A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yeq ALKALINE PHOSPHATASE
D

(Bacillus
subtilis) 		PF09423
(PhoD)
PF16655
(PhoD_N) 		3 ARG A 282
ASP A 151
ASN A 216
 None
CA  A1525 (-2.4A)
CA  A1526 (-3.3A)
 0.85A 2zzmA-2yeqA:
undetectable		 2zzmA-2yeqA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqy HYPOTHETICAL PROTEIN
TTHA0303

(Thermus
thermophilus) 		PF12867
(DinB_2) 		3 ARG A 150
ASP A 128
ASN A 144
 None
 0.86A 2zzmA-2yqyA:
undetectable		 2zzmA-2yqyA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		3 ARG A  98
ASP A 281
ASN A 120
 None
 0.84A 2zzmA-3a24A:
undetectable		 2zzmA-3a24A:
20.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ay0 UNCHARACTERIZED
PROTEIN MJ0883

(Methanocaldococcus
jannaschii) 		PF02475
(Met_10) 		3 ARG A 186
ASP A 223
ASN A 265
 None
ADN  A 401 (-2.6A)
ADN  A 401 (-4.9A)
 0.62A 2zzmA-3ay0A:
36.3		 2zzmA-3ay0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckk TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Homo sapiens) 		PF02390
(Methyltransf_4) 		3 ARG A 216
ASP A 169
ASN A 217
 None
 0.84A 2zzmA-3ckkA:
10.3		 2zzmA-3ckkA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1t TYPE I SITE-SPECIFIC
RESTRICTION-MODIFICA
TION SYSTEM, R
(RESTRICTION)
SUBUNIT

(Vibrio
vulnificus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF13588
(HSDR_N_2) 		3 ARG A 456
ASP A 423
ASN A 461
 None
 0.83A 2zzmA-3h1tA:
4.5		 2zzmA-3h1tA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i36 VASCULAR PROTEIN
TYROSINE PHOSPHATASE
1

(Rattus
norvegicus) 		PF00102
(Y_phosphatase) 		3 ARG A 960
ASP A1001
ASN A 944
 None
 0.81A 2zzmA-3i36A:
undetectable		 2zzmA-3i36A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij3 CYTOSOL
AMINOPEPTIDASE

(Coxiella
burnetii) 		PF00883
(Peptidase_M17) 		3 ARG A 120
ASP A 151
ASN A 117
 None
 0.89A 2zzmA-3ij3A:
undetectable		 2zzmA-3ij3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jck 26S PROTEASOME
REGULATORY SUBUNIT
RPN3

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF08375
(Rpn3_C) 		3 ARG A 196
ASP A 375
ASN A 243
 None
 0.75A 2zzmA-3jckA:
undetectable		 2zzmA-3jckA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		3 ARG A 230
ASP A 500
ASN A 239
 None
 0.85A 2zzmA-3lppA:
undetectable		 2zzmA-3lppA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR

(Legionella
pneumophila) 		PF14860
(DrrA_P4M) 		3 ARG A 453
ASP A 445
ASN A 451
 None
 0.89A 2zzmA-3n6oA:
undetectable		 2zzmA-3n6oA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		3 ARG A 391
ASP A 106
ASN A 270
 None
 0.61A 2zzmA-3pihA:
undetectable		 2zzmA-3pihA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		3 ARG A 286
ASP A 334
ASN A 270
 None
 0.90A 2zzmA-3ps5A:
undetectable		 2zzmA-3ps5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus scrofa) 		PF00305
(Lipoxygenase) 		3 ARG A 364
ASP A 352
ASN A 544
 None
 0.82A 2zzmA-3rdeA:
undetectable		 2zzmA-3rdeA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2j DIPEPTIDASE

(Streptomyces
coelicolor) 		PF01244
(Peptidase_M19) 		3 ARG A   8
ASP A 333
ASN A 339
 None
 0.73A 2zzmA-3s2jA:
undetectable		 2zzmA-3s2jA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s3f TYROSINE-PROTEIN
PHOSPHATASE 10D

(Drosophila
melanogaster) 		PF00102
(Y_phosphatase) 		3 ARG A  86
ASP A 128
ASN A  70
 None
 0.72A 2zzmA-3s3fA:
undetectable		 2zzmA-3s3fA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0a NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		3 ARG B1043
ASP B1110
ASN B1148
 None
 0.89A 2zzmA-3v0aB:
undetectable		 2zzmA-3v0aB:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi1 ALKALINE
METALLOPROTEINASE

(Pseudomonas
aeruginosa) 		PF08548
(Peptidase_M10_C)
PF13583
(Reprolysin_4) 		3 ARG A 393
ASP A 435
ASN A 458
 None
 0.73A 2zzmA-3vi1A:
undetectable		 2zzmA-3vi1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00005
(ABC_tran) 		3 ARG A 419
ASP A 107
ASN A 276
 None
 0.43A 2zzmA-3zqjA:
undetectable		 2zzmA-3zqjA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00005
(ABC_tran) 		3 ARG A 783
ASP A 722
ASN A 747
 None
 0.58A 2zzmA-3zqjA:
undetectable		 2zzmA-3zqjA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aie GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Lactobacillus
acidophilus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 ARG A 177
ASP A 206
ASN A 170
 None
 0.85A 2zzmA-4aieA:
undetectable		 2zzmA-4aieA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au0 EXOGLUCANASE 2

(Trichoderma
reesei) 		PF01341
(Glyco_hydro_6) 		3 ARG A 353
ASP A 419
ASN A 369
 None
 0.89A 2zzmA-4au0A:
undetectable		 2zzmA-4au0A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A1432
ASP A1474
ASN A1416
 None
 0.88A 2zzmA-4bpcA:
undetectable		 2zzmA-4bpcA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A1721
ASP A1763
ASN A1705
 None
 0.80A 2zzmA-4bpcA:
undetectable		 2zzmA-4bpcA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE

(Mycobacterium
avium) 		PF04909
(Amidohydro_2) 		3 ARG A 381
ASP A 113
ASN A   5
 None
 0.88A 2zzmA-4dziA:
undetectable		 2zzmA-4dziA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxw ADENOSINE DEAMINASE

(Burkholderia
ambifaria) 		PF00962
(A_deaminase) 		3 ARG A 272
ASP A 301
ASN A 267
 None
 0.86A 2zzmA-4gxwA:
undetectable		 2zzmA-4gxwA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikc PHOSPHOTIDYLINOSITOL
PHOSPHATASE PTPRQ

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A2722
ASP A2764
ASN A2706
 None
 0.88A 2zzmA-4ikcA:
undetectable		 2zzmA-4ikcA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Francisella
tularensis) 		PF00155
(Aminotran_1_2) 		3 ARG A 274
ASP A  36
ASN A 273
 None
 0.79A 2zzmA-4iw7A:
2.2		 2zzmA-4iw7A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jat ALPHA-PYRONE
SYNTHESIS POLYKETIDE
SYNTHASE-LIKE PKS11

(Mycobacterium
tuberculosis) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 ARG A 207
ASP A  97
ASN A  92
 None
 0.61A 2zzmA-4jatA:
undetectable		 2zzmA-4jatA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqn D-HYDANTOINASE

(Bacillus sp.
AR9) 		PF01979
(Amidohydro_1) 		3 ARG A  79
ASP A  62
ASN A 412
 ARG  A  79 ( 0.6A)
ASP  A  62 ( 0.6A)
ASN  A 412 ( 0.6A)
 0.89A 2zzmA-4kqnA:
undetectable		 2zzmA-4kqnA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1a CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		3 ARG A 996
ASP A1006
ASN A1012
 None
 0.83A 2zzmA-4n1aA:
1.9		 2zzmA-4n1aA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnd TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 18

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A  72
ASP A 114
ASN A  56
 None
 0.79A 2zzmA-4nndA:
undetectable		 2zzmA-4nndA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Chloroflexus
aurantiacus) 		PF13407
(Peripla_BP_4) 		3 ARG A 142
ASP A 145
ASN A 347
 None
 0.75A 2zzmA-4rxuA:
undetectable		 2zzmA-4rxuA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3o E3 UBIQUITIN-PROTEIN
LIGASE RING2
POLYCOMB GROUP RING
FINGER PROTEIN 5

(Homo sapiens;
Homo sapiens) 		PF13923
(zf-C3HC4_2)
PF13923
(zf-C3HC4_2) 		3 ARG C  55
ASP C  72
ASN B 105
 None
 0.86A 2zzmA-4s3oC:
undetectable		 2zzmA-4s3oC:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus) 		no annotation 3 ARG B 137
ASP B 357
ASN B 421
 PQQ  B 702 (-3.0A)
None
PQQ  B 702 (-3.7A)
 0.80A 2zzmA-4tqoB:
undetectable		 2zzmA-4tqoB:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uu2 FERULIC ACID
DECARBOXYLASE

(Enterobacter
sp.) 		PF05870
(PA_decarbox) 		3 ARG A 142
ASP A  38
ASN A 148
 None
 0.87A 2zzmA-4uu2A:
undetectable		 2zzmA-4uu2A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN

(Mycolicibacterium
thermoresistibile) 		PF00722
(Glyco_hydro_16) 		3 ARG A 117
ASP A  30
ASN A  80
 BEZ  A 306 (-3.5A)
None
None
 0.75A 2zzmA-4xdqA:
undetectable		 2zzmA-4xdqA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqe HOMOSPERMIDINE
SYNTHASE

(Blastochloris
viridis) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		3 ARG A 211
ASP A 358
ASN A 329
 None
 0.70A 2zzmA-4xqeA:
3.5		 2zzmA-4xqeA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE

(Saccharophagus
degradans) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		3 ARG A 349
ASP A 345
ASN A 350
 LGC  A 804 (-4.0A)
GOL  A 802 (-3.0A)
LGC  A 804 (-3.0A)
 0.76A 2zzmA-4zlgA:
undetectable		 2zzmA-4zlgA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Homo sapiens) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
PF09336
(Vps4_C) 		3 ARG A  95
ASP A 204
ASN A  90
 None
 0.67A 2zzmA-5c1bA:
undetectable		 2zzmA-5c1bA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Arabidopsis
thaliana) 		PF02446
(Glyco_hydro_77) 		3 ARG A 246
ASP A 140
ASN A 308
 None
 0.80A 2zzmA-5csuA:
undetectable		 2zzmA-5csuA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgq PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN

(Photobacterium
profundum) 		PF00759
(Glyco_hydro_9) 		3 ARG A 364
ASP A 303
ASN A 308
 None
 0.88A 2zzmA-5dgqA:
undetectable		 2zzmA-5dgqA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ek8 LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		3 ARG A 487
ASP A 551
ASN A 545
 None
 0.82A 2zzmA-5ek8A:
undetectable		 2zzmA-5ek8A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h08 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A1766
ASP A1810
ASN A1750
 None
 0.84A 2zzmA-5h08A:
undetectable		 2zzmA-5h08A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		3 ARG A 289
ASP A 340
ASN A 273
 None
 0.90A 2zzmA-5i6vA:
undetectable		 2zzmA-5i6vA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m7r PROTEIN O-GLCNACASE

(Homo sapiens) 		PF07555
(NAGidase) 		3 ARG A 610
ASP A 600
ASN A 588
 None
 0.79A 2zzmA-5m7rA:
undetectable		 2zzmA-5m7rA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mj7 UNCHARACTERIZED
PROTEIN

(Caenorhabditis
elegans) 		PF01156
(IU_nuc_hydro) 		3 ARG A 286
ASP A 277
ASN A 281
 None
 0.75A 2zzmA-5mj7A:
2.8		 2zzmA-5mj7A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no8 BACCELL_00875

(Bacteroides
cellulosilyticus) 		no annotation 3 ARG A 395
ASP A 441
ASN A 379
 None
 0.78A 2zzmA-5no8A:
undetectable		 2zzmA-5no8A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9w THEBAINE
6-O-DEMETHYLASE

(Papaver
somniferum) 		no annotation 3 ARG A 305
ASP A 144
ASN A 221
 AKG  A 402 (-2.7A)
None
AKG  A 402 (-3.7A)
 0.86A 2zzmA-5o9wA:
undetectable		 2zzmA-5o9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olj DIPEPTIDYL PEPTIDASE
IV

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 ARG A 635
ASP A 273
ASN A 300
 None
 0.81A 2zzmA-5oljA:
undetectable		 2zzmA-5oljA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ols RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 ARG A 319
ASP A 215
ASN A 324
 GTR  A 608 (-3.0A)
CA  A 601 (-2.1A)
RAM  A 607 (-2.8A)
 0.78A 2zzmA-5olsA:
undetectable		 2zzmA-5olsA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tt0 OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Burkholderia
thailandensis) 		PF13561
(adh_short_C2) 		3 ARG A  74
ASP A  68
ASN A  72
 None
EDO  A 307 ( 4.5A)
None
 0.84A 2zzmA-5tt0A:
6.9		 2zzmA-5tt0A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucr PANTOTHENATE
SYNTHETASE

(Neisseria
gonorrhoeae) 		PF02569
(Pantoate_ligase) 		3 ARG A  41
ASP A 139
ASN A  46
 None
 0.86A 2zzmA-5ucrA:
2.4		 2zzmA-5ucrA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN 70
KDA HOMOLOG
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN C

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		3 ARG B 124
ASP B 103
ASN A   2
 None
 0.76A 2zzmA-5uz5B:
undetectable		 2zzmA-5uz5B:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdu BNAB NIH45-46 SCFV
HEAVY CHAIN

(Homo sapiens) 		no annotation 3 ARG D  53
ASP D  76
ASN D  31
 None
 0.62A 2zzmA-5wduD:
undetectable		 2zzmA-5wduD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcy GLUCANASE

(Phanerochaete
chrysosporium) 		PF01341
(Glyco_hydro_6) 		3 ARG A 347
ASP A 412
ASN A 362
 None
 0.89A 2zzmA-5xcyA:
undetectable		 2zzmA-5xcyA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfm ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 ARG A 392
ASP A 427
ASN A 386
 None
 0.86A 2zzmA-5xfmA:
undetectable		 2zzmA-5xfmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xm3 GLUCOSE
DEHYDROGENASE

(Methylophaga
aminisulfidivorans) 		no annotation 3 ARG A 140
ASP A 361
ASN A 425
 PQQ  A 701 (-3.3A)
None
PQQ  A 701 (-3.4A)
 0.83A 2zzmA-5xm3A:
undetectable		 2zzmA-5xm3A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B

(Pyrococcus
abyssi) 		PF02475
(Met_10) 		3 ARG A 173
ASP A 211
ASN A 252
 None
 0.60A 2zzmA-5yacA:
31.0		 2zzmA-5yacA:
42.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bs7 ADENYLOSUCCINATE
SYNTHETASE

(Legionella
pneumophila) 		no annotation 3 ARG A 148
ASP A 204
ASN A  71
 None
 0.76A 2zzmA-6bs7A:
2.1		 2zzmA-6bs7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwe PUTATIVE FIMBRIAL
ASSOCIATED
SORTASE-LIKE PROTEIN

(Corynebacterium
diphtheriae) 		no annotation 3 ARG A 235
ASP A 204
ASN A 198
 None
 0.72A 2zzmA-6bweA:
undetectable		 2zzmA-6bweA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d1w POLYCYSTIN-2

(Homo sapiens) 		no annotation 3 ARG A 440
ASP A 394
ASN A 547
 None
 0.80A 2zzmA-6d1wA:
undetectable		 2zzmA-6d1wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 3 ARG A 827
ASP A1309
ASN A  35
 None
 0.83A 2zzmA-6eojA:
undetectable		 2zzmA-6eojA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fi2 VEXL

(Achromobacter
denitrificans) 		no annotation 3 ARG A 172
ASP A 122
ASN A 151
 None
 0.78A 2zzmA-6fi2A:
undetectable		 2zzmA-6fi2A:
undetectable