SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZXW_P_CHDP1271_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2i PROTEIN (RESTRICTION
ENDONUCLEASE BGLII)

(Bacillus
subtilis) 		PF09195
(Endonuc-BglII) 		4 LEU A 102
GLN A  95
LEU A 152
PHE A 161
 None
MG  A 601 ( 4.1A)
None
None
 0.95A 2zxwP-1d2iA:
undetectable
2zxwW-1d2iA:
0.0		 2zxwP-1d2iA:
19.62
2zxwW-1d2iA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqn DNA PRIMASE

(Escherichia
coli) 		PF08275
(Toprim_N)
PF10410
(DnaB_bind)
PF13155
(Toprim_2) 		4 LEU A 296
GLN A 295
PHE A 298
LEU A 245
 None
 1.03A 2zxwP-1eqnA:
undetectable
2zxwW-1eqnA:
0.0		 2zxwP-1eqnA:
20.43
2zxwW-1eqnA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2r INHIBITOR OF
CASPASE-ACTIVATED
DNASE

(Mus musculus) 		PF02017
(CIDE-N) 		4 LEU I  23
GLN I  31
LEU I  42
PHE I  76
 None
 0.99A 2zxwP-1f2rI:
undetectable
2zxwW-1f2rI:
undetectable		 2zxwP-1f2rI:
17.97
2zxwW-1f2rI:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.99A 2zxwP-1hkkA:
0.1
2zxwW-1hkkA:
0.0		 2zxwP-1hkkA:
21.66
2zxwW-1hkkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkw CYCLIN H

(Homo sapiens) 		PF00134
(Cyclin_N)
PF16899
(Cyclin_C_2) 		4 ARG A 102
LEU A 106
PHE A 110
LEU A 129
 None
 0.93A 2zxwP-1jkwA:
0.7
2zxwW-1jkwA:
0.0		 2zxwP-1jkwA:
20.52
2zxwW-1jkwA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1juv DIHYDROFOLATE
REDUCTASE

(Escherichia
virus T4) 		PF00186
(DHFR_1) 		4 LEU A  20
GLN A 159
PHE A  22
LEU A 165
 None
None
NDP  A 194 (-3.6A)
None
 0.99A 2zxwP-1juvA:
undetectable
2zxwW-1juvA:
0.0		 2zxwP-1juvA:
18.99
2zxwW-1juvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkc MANGANESE SUPEROXIDE
DISMUTASE

(Aspergillus
fumigatus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 LEU A  28
GLN A  29
LEU A  95
PHE A  91
 None
 0.85A 2zxwP-1kkcA:
2.5
2zxwW-1kkcA:
0.0		 2zxwP-1kkcA:
19.93
2zxwW-1kkcA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 ARG A 217
LEU A 221
GLN A 223
LEU A 287
 None
 0.95A 2zxwP-1lnlA:
0.3
2zxwW-1lnlA:
0.0		 2zxwP-1lnlA:
20.98
2zxwW-1lnlA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m33 BIOH PROTEIN

(Escherichia
coli) 		PF00561
(Abhydrolase_1) 		4 LEU A 132
GLN A 131
PHE A 128
LEU A 176
 None
 0.89A 2zxwP-1m33A:
undetectable
2zxwW-1m33A:
undetectable		 2zxwP-1m33A:
20.57
2zxwW-1m33A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)

(Escherichia
coli) 		PF01464
(SLT)
PF14718
(SLT_L) 		4 LEU A 246
GLN A 245
LEU A 254
PHE A 222
 None
SO4  A 706 (-3.3A)
None
None
 1.02A 2zxwP-1qsaA:
undetectable
2zxwW-1qsaA:
undetectable		 2zxwP-1qsaA:
17.26
2zxwW-1qsaA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj7 ECTODYSPLASIN A

(Homo sapiens) 		PF00229
(TNF) 		4 LEU A 253
GLN A 254
PHE A 379
PHE A 284
 None
 0.89A 2zxwP-1rj7A:
undetectable
2zxwW-1rj7A:
undetectable		 2zxwP-1rj7A:
19.93
2zxwW-1rj7A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8v GAMMA-AMINOBUTYRATE
METABOLISM
DEHYDRATASE/ISOMERAS
E

(Clostridium
aminobutyricum) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 ARG A 433
LEU A 437
LEU A 391
PHE A 422
 None
 0.86A 2zxwP-1u8vA:
3.8
2zxwW-1u8vA:
undetectable		 2zxwP-1u8vA:
19.70
2zxwW-1u8vA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8d HYPOTHETICAL PROTEIN
(TT1679)

(Thermus
thermophilus) 		PF04260
(DUF436) 		4 LEU A  55
GLN A  56
LEU A 100
PHE A  66
 None
 1.02A 2zxwP-1v8dA:
undetectable
2zxwW-1v8dA:
undetectable		 2zxwP-1v8dA:
21.82
2zxwW-1v8dA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyn ARGONAUTE2

(Drosophila
melanogaster) 		PF02170
(PAZ) 		5 ARG A  30
LEU A  11
PHE A  14
LEU A  33
PHE A  32
 None
 1.50A 2zxwP-1vynA:
undetectable
2zxwW-1vynA:
undetectable		 2zxwP-1vynA:
22.73
2zxwW-1vynA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.91A 2zxwP-1wb0A:
undetectable
2zxwW-1wb0A:
undetectable		 2zxwP-1wb0A:
19.69
2zxwW-1wb0A:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y76 PROTEIN ASSOCIATED
TO TIGHT JUNCTIONS

(Rattus
norvegicus) 		PF09045
(L27_2) 		4 LEU A  13
GLN A  14
LEU A  42
PHE A  38
 None
 0.92A 2zxwP-1y76A:
undetectable
2zxwW-1y76A:
undetectable		 2zxwP-1y76A:
13.03
2zxwW-1y76A:
33.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli) 		PF04952
(AstE_AspA) 		4 LEU A 184
PHE A 158
LEU A 176
PHE A 172
 None
 0.87A 2zxwP-1yw6A:
undetectable
2zxwW-1yw6A:
undetectable		 2zxwP-1yw6A:
20.54
2zxwW-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)

(Paracoccus
denitrificans) 		PF06433
(Me-amine-dh_H) 		4 ARG H 119
GLN H 142
PHE H 143
PHE H  66
 None
 0.85A 2zxwP-2bbkH:
undetectable
2zxwW-2bbkH:
undetectable		 2zxwP-2bbkH:
20.44
2zxwW-2bbkH:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2brt LEUCOANTHOCYANIDIN
DIOXYGENASE

(Arabidopsis
thaliana) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 LEU A 210
GLN A 211
PHE A 304
LEU A 176
 None
None
NAR  A1352 ( 3.5A)
None
 0.93A 2zxwP-2brtA:
undetectable
2zxwW-2brtA:
undetectable		 2zxwP-2brtA:
19.40
2zxwW-2brtA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE

(Pyrococcus
furiosus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 LEU A 522
GLN A 511
PHE A 520
LEU A 428
 None
 0.89A 2zxwP-2cfmA:
undetectable
2zxwW-2cfmA:
undetectable		 2zxwP-2cfmA:
17.30
2zxwW-2cfmA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgc ACETOLACTATE
SYNTHASE, SMALL
SUBUNIT

(Thermotoga
maritima) 		PF01842
(ACT)
PF10369
(ALS_ss_C) 		4 LEU A 132
GLN A 131
PHE A 130
LEU A 166
 None
 1.00A 2zxwP-2fgcA:
undetectable
2zxwW-2fgcA:
undetectable		 2zxwP-2fgcA:
19.39
2zxwW-2fgcA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2in3 HYPOTHETICAL PROTEIN

(Nitrosomonas
europaea) 		PF01323
(DSBA) 		4 GLN A 117
PHE A 120
LEU A 133
PHE A 151
 None
 0.94A 2zxwP-2in3A:
undetectable
2zxwW-2in3A:
undetectable		 2zxwP-2in3A:
22.22
2zxwW-2in3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaa R.MVAI

(Kocuria varians) 		PF15515
(MvaI_BcnI) 		4 LEU A 156
GLN A 155
LEU A 190
PHE A 187
 None
 1.03A 2zxwP-2oaaA:
undetectable
2zxwW-2oaaA:
undetectable		 2zxwP-2oaaA:
20.00
2zxwW-2oaaA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2olt HYPOTHETICAL PROTEIN

(Shewanella
oneidensis) 		PF01865
(PhoU_div) 		4 LEU A 117
GLN A 118
PHE A 121
LEU A 183
 None
 0.74A 2zxwP-2oltA:
3.1
2zxwW-2oltA:
undetectable		 2zxwP-2oltA:
22.38
2zxwW-2oltA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opt ACTII PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 ARG A  75
LEU A  79
PHE A  83
LEU A  49
 None
 0.71A 2zxwP-2optA:
3.1
2zxwW-2optA:
undetectable		 2zxwP-2optA:
23.19
2zxwW-2optA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0x UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF08538
(DUF1749) 		4 LEU A 288
GLN A 289
PHE A 290
LEU A  64
 None
 0.89A 2zxwP-2q0xA:
undetectable
2zxwW-2q0xA:
undetectable		 2zxwP-2q0xA:
23.31
2zxwW-2q0xA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE

(Corynebacterium
glutamicum) 		PF00478
(IMPDH) 		4 LEU A 363
GLN A 367
PHE A 366
PHE A  51
 None
 0.75A 2zxwP-2qr6A:
undetectable
2zxwW-2qr6A:
undetectable		 2zxwP-2qr6A:
17.81
2zxwW-2qr6A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv8 GENERAL SECRETION
PATHWAY PROTEIN H

(Vibrio cholerae) 		PF12019
(GspH) 		4 LEU A 177
GLN A 172
LEU A  43
PHE A  39
 None
 0.96A 2zxwP-2qv8A:
undetectable
2zxwW-2qv8A:
undetectable		 2zxwP-2qv8A:
17.74
2zxwW-2qv8A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4g TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		PF12009
(Telomerase_RBD) 		4 GLN A 382
PHE A 379
LEU A 405
PHE A 401
 None
 0.91A 2zxwP-2r4gA:
undetectable
2zxwW-2r4gA:
undetectable		 2zxwP-2r4gA:
19.66
2zxwW-2r4gA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		4 LEU A 180
PHE A 349
LEU A  60
PHE A 315
 None
 1.03A 2zxwP-2xn6A:
undetectable
2zxwW-2xn6A:
undetectable		 2zxwP-2xn6A:
20.83
2zxwW-2xn6A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b86 GENERAL
ODORANT-BINDING
PROTEIN LUSH

(Drosophila
melanogaster) 		PF01395
(PBP_GOBP) 		4 LEU A  44
PHE A  21
LEU A  31
PHE A  36
 None
 0.97A 2zxwP-3b86A:
undetectable
2zxwW-3b86A:
undetectable		 2zxwP-3b86A:
17.60
2zxwW-3b86A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c75 METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN

(Paracoccus
versutus) 		PF06433
(Me-amine-dh_H) 		4 ARG H 172
GLN H 195
PHE H 196
PHE H 119
 None
 0.77A 2zxwP-3c75H:
undetectable
2zxwW-3c75H:
undetectable		 2zxwP-3c75H:
19.95
2zxwW-3c75H:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmn PUTATIVE HYDROLASE

(Chloroflexus
aurantiacus) 		PF10103
(Zincin_2) 		4 GLN A 118
PHE A 120
LEU A 232
PHE A 228
 None
 1.02A 2zxwP-3cmnA:
undetectable
2zxwW-3cmnA:
undetectable		 2zxwP-3cmnA:
21.80
2zxwW-3cmnA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr8 SULFATE
ADENYLYLTRANSFERASE,
ADENYLYLSULFATE
KINASE

(Thiobacillus
denitrificans) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A  74
GLN A  73
PHE A  79
LEU A  56
 None
 0.94A 2zxwP-3cr8A:
undetectable
2zxwW-3cr8A:
undetectable		 2zxwP-3cr8A:
20.53
2zxwW-3cr8A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1d RNA-INDUCED
TRANSCRIPTIONAL
SILENCING COMPLEX
PROTEIN TAS3

(Schizosaccharomyces
pombe) 		no annotation 4 LEU A 477
GLN A 478
LEU A 443
PHE A 449
 None
 1.02A 2zxwP-3d1dA:
undetectable
2zxwW-3d1dA:
undetectable		 2zxwP-3d1dA:
19.47
2zxwW-3d1dA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqv CULLIN-5

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 LEU C1600
GLN C1599
PHE C1598
LEU C1551
 None
 0.90A 2zxwP-3dqvC:
undetectable
2zxwW-3dqvC:
undetectable		 2zxwP-3dqvC:
20.37
2zxwW-3dqvC:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exn PROBABLE
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF00583
(Acetyltransf_1) 		4 LEU A  63
PHE A  62
LEU A  22
PHE A  26
 None
 0.83A 2zxwP-3exnA:
undetectable
2zxwW-3exnA:
undetectable		 2zxwP-3exnA:
23.02
2zxwW-3exnA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1z PUTATIVE LYSYL-TRNA
SYNTHETASE

(Salmonella
enterica) 		PF00152
(tRNA-synt_2) 		4 ARG A 188
LEU A 192
GLN A 193
PHE A 196
 None
 0.69A 2zxwP-3g1zA:
undetectable
2zxwW-3g1zA:
undetectable		 2zxwP-3g1zA:
20.94
2zxwW-3g1zA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzg MOLYBDATE-BINDING
PERIPLASMIC PROTEIN
PERMEASE

(Xanthomonas
citri) 		PF13531
(SBP_bac_11) 		4 LEU A  80
PHE A 230
LEU A 216
PHE A 212
 None
 0.91A 2zxwP-3gzgA:
undetectable
2zxwW-3gzgA:
undetectable		 2zxwP-3gzgA:
24.09
2zxwW-3gzgA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kt4 PKHD-TYPE
HYDROXYLASE TPA1

(Saccharomyces
cerevisiae) 		PF10637
(Ofd1_CTDD)
PF13661
(2OG-FeII_Oxy_4) 		4 LEU A 355
GLN A 356
PHE A 359
PHE A 370
 None
 0.97A 2zxwP-3kt4A:
undetectable
2zxwW-3kt4A:
undetectable		 2zxwP-3kt4A:
18.26
2zxwW-3kt4A:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6c SERINE RACEMASE

(Rattus
norvegicus) 		PF00291
(PALP) 		4 LEU A 171
GLN A 173
LEU A 200
PHE A   9
 None
 0.99A 2zxwP-3l6cA:
undetectable
2zxwW-3l6cA:
undetectable		 2zxwP-3l6cA:
21.73
2zxwW-3l6cA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6r SERINE RACEMASE

(Homo sapiens) 		PF00291
(PALP) 		4 LEU A 171
GLN A 173
LEU A 200
PHE A   9
 None
 0.98A 2zxwP-3l6rA:
undetectable
2zxwW-3l6rA:
undetectable		 2zxwP-3l6rA:
21.74
2zxwW-3l6rA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS

(Streptomyces
sp. CK4412) 		PF00975
(Thioesterase) 		4 LEU A 229
GLN A 227
LEU A 178
PHE A 182
 None
 1.03A 2zxwP-3lcrA:
undetectable
2zxwW-3lcrA:
undetectable		 2zxwP-3lcrA:
20.45
2zxwW-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvu TENA FAMILY
TRANSCRIPTIONAL
REGULATOR

(Ruegeria sp.
TM1040) 		PF03070
(TENA_THI-4) 		4 LEU A 204
PHE A 208
LEU A 187
PHE A 195
 None
None
None
EDO  A 231 (-3.8A)
 0.96A 2zxwP-3mvuA:
undetectable
2zxwW-3mvuA:
undetectable		 2zxwP-3mvuA:
20.30
2zxwW-3mvuA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbu GLUCOSE-6-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00342
(PGI) 		4 LEU A  15
GLN A  16
PHE A  19
LEU A  66
 None
 0.51A 2zxwP-3nbuA:
undetectable
2zxwW-3nbuA:
undetectable		 2zxwP-3nbuA:
18.63
2zxwW-3nbuA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocj PUTATIVE EXPORTED
PROTEIN

(Bordetella
parapertussis) 		PF13847
(Methyltransf_31) 		4 LEU A 252
GLN A 251
PHE A 254
LEU A  44
 None
None
GOL  A 303 ( 4.4A)
None
 0.91A 2zxwP-3ocjA:
undetectable
2zxwW-3ocjA:
undetectable		 2zxwP-3ocjA:
23.24
2zxwW-3ocjA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4

(Saccharomyces
cerevisiae) 		PF11701
(UNC45-central) 		4 LEU A 295
GLN A 294
LEU A 271
PHE A 267
 None
 0.94A 2zxwP-3opbA:
undetectable
2zxwW-3opbA:
undetectable		 2zxwP-3opbA:
14.10
2zxwW-3opbA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl0 UNCHARACTERIZED
PROTEIN

(Methylibium
petroleiphilum) 		PF10014
(2OG-Fe_Oxy_2) 		4 LEU A  15
GLN A  16
LEU A 129
PHE A 130
 None
 0.82A 2zxwP-3pl0A:
undetectable
2zxwW-3pl0A:
undetectable		 2zxwP-3pl0A:
21.36
2zxwW-3pl0A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8i ODORANT BINDING
PROTEIN

(Anopheles
gambiae) 		PF01395
(PBP_GOBP) 		4 LEU A  44
PHE A  21
LEU A  31
PHE A  36
 None
 1.00A 2zxwP-3q8iA:
undetectable
2zxwW-3q8iA:
undetectable		 2zxwP-3q8iA:
17.72
2zxwW-3q8iA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd5 MYPAA.01249.C

(Mycobacterium
avium) 		PF00106
(adh_short) 		4 ARG A 131
LEU A 191
PHE A 246
LEU A 241
 None
 1.03A 2zxwP-3rd5A:
undetectable
2zxwW-3rd5A:
undetectable		 2zxwP-3rd5A:
21.79
2zxwW-3rd5A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B

(Homo sapiens;
Mus musculus;
Rattus
norvegicus) 		PF02828
(L27)
PF09045
(L27_2)
PF09060
(L27_N) 		4 LEU A  13
GLN A  14
LEU A  42
PHE A  38
 None
 1.02A 2zxwP-3uitA:
undetectable
2zxwW-3uitA:
undetectable		 2zxwP-3uitA:
21.99
2zxwW-3uitA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wi3 DNA REPLICATION
REGULATOR SLD3

(Saccharomyces
cerevisiae) 		PF08639
(SLD3) 		4 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 1.02A 2zxwP-3wi3A:
1.8
2zxwW-3wi3A:
undetectable		 2zxwP-3wi3A:
18.93
2zxwW-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE

(Pyrococcus
abyssi) 		PF00589
(Phage_integrase)
PF02899
(Phage_int_SAM_1) 		4 ARG A 184
LEU A 181
LEU A 191
PHE A 192
 None
 0.88A 2zxwP-4a8eA:
undetectable
2zxwW-4a8eA:
undetectable		 2zxwP-4a8eA:
19.68
2zxwW-4a8eA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bju N-ACETYLGLUCOSAMINE-
PHOSPHATE MUTASE

(Aspergillus
fumigatus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		4 LEU A 414
GLN A 415
LEU A 320
PHE A 316
 None
 0.92A 2zxwP-4bjuA:
undetectable
2zxwW-4bjuA:
undetectable		 2zxwP-4bjuA:
16.94
2zxwW-4bjuA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF04054
(Not1) 		4 GLN A2252
PHE A2251
LEU A2196
PHE A2192
 None
 0.92A 2zxwP-4c0dA:
2.6
2zxwW-4c0dA:
undetectable		 2zxwP-4c0dA:
14.62
2zxwW-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF04054
(Not1) 		4 LEU A1975
GLN A1976
LEU A2026
PHE A2034
 None
 0.93A 2zxwP-4c0dA:
2.6
2zxwW-4c0dA:
undetectable		 2zxwP-4c0dA:
14.62
2zxwW-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN

(Helicobacter
pylori) 		no annotation 4 LEU P  30
GLN P  31
PHE P  34
PHE P 219
 None
 0.96A 2zxwP-4dvyP:
undetectable
2zxwW-4dvyP:
undetectable		 2zxwP-4dvyP:
13.39
2zxwW-4dvyP:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eq5 DNA LIGASE

(Thermococcus
sibiricus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 LEU A 534
GLN A 523
PHE A 532
LEU A 440
 None
 0.77A 2zxwP-4eq5A:
undetectable
2zxwW-4eq5A:
undetectable		 2zxwP-4eq5A:
16.64
2zxwW-4eq5A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.97A 2zxwP-4flxA:
2.6
2zxwW-4flxA:
undetectable		 2zxwP-4flxA:
13.49
2zxwW-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqn MALCAVERNIN

(Homo sapiens) 		PF16545
(CCM2_C) 		5 ARG A 354
LEU A 351
PHE A 348
LEU A 369
PHE A 365
 None
 1.50A 2zxwP-4fqnA:
undetectable
2zxwW-4fqnA:
undetectable		 2zxwP-4fqnA:
14.18
2zxwW-4fqnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdo KREV INTERACTION
TRAPPED PROTEIN 1

(Homo sapiens) 		PF00373
(FERM_M) 		4 LEU A 621
GLN A 622
PHE A 625
LEU A 608
 None
 0.98A 2zxwP-4hdoA:
undetectable
2zxwW-4hdoA:
undetectable		 2zxwP-4hdoA:
20.67
2zxwW-4hdoA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans) 		PF11701
(UNC45-central) 		4 LEU A 373
GLN A 374
LEU A 347
PHE A 420
 None
 0.93A 2zxwP-4i2wA:
undetectable
2zxwW-4i2wA:
undetectable		 2zxwP-4i2wA:
14.04
2zxwW-4i2wA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 228
PHE A 230
LEU A 203
PHE A 199
 None
 1.00A 2zxwP-4j0mA:
undetectable
2zxwW-4j0mA:
undetectable		 2zxwP-4j0mA:
16.01
2zxwW-4j0mA:
5.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		4 LEU A 412
GLN A 413
LEU A 378
PHE A 374
 None
 1.01A 2zxwP-4kriA:
undetectable
2zxwW-4kriA:
undetectable		 2zxwP-4kriA:
21.21
2zxwW-4kriA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis) 		PF02222
(ATP-grasp) 		4 LEU A 137
GLN A 149
PHE A 150
LEU A 124
 None
ANP  A 401 ( 4.5A)
None
None
 0.97A 2zxwP-4ma5A:
undetectable
2zxwW-4ma5A:
undetectable		 2zxwP-4ma5A:
22.16
2zxwW-4ma5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4f INOSITOL
HEXAKISPHOSPHATE
KINASE

(Entamoeba
histolytica) 		PF03770
(IPK) 		4 LEU A 191
GLN A 190
PHE A 187
LEU A 256
 None
 0.85A 2zxwP-4o4fA:
undetectable
2zxwW-4o4fA:
undetectable		 2zxwP-4o4fA:
21.40
2zxwW-4o4fA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		4 GLN A 375
PHE A 372
LEU A 299
PHE A 301
 None
 0.93A 2zxwP-4oyaA:
undetectable
2zxwW-4oyaA:
undetectable		 2zxwP-4oyaA:
19.62
2zxwW-4oyaA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica) 		PF13407
(Peripla_BP_4) 		4 LEU A  31
GLN A  69
LEU A  42
PHE A  38
 None
None
None
INS  A 401 (-4.5A)
 1.02A 2zxwP-4rxmA:
undetectable
2zxwW-4rxmA:
undetectable		 2zxwP-4rxmA:
20.81
2zxwW-4rxmA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud4 POLY(A) RNA
POLYMERASE PROTEIN
CID1

(Schizosaccharomyces
pombe) 		PF01909
(NTP_transf_2)
PF03828
(PAP_assoc) 		4 LEU A 145
GLN A 158
LEU A 125
PHE A 121
 None
 1.00A 2zxwP-4ud4A:
undetectable
2zxwW-4ud4A:
undetectable		 2zxwP-4ud4A:
19.95
2zxwW-4ud4A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wn9 NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		4 LEU A 334
GLN A 335
LEU A 503
PHE A 499
 None
None
XE  A 604 ( 4.2A)
XE  A 604 (-3.8A)
 0.77A 2zxwP-4wn9A:
undetectable
2zxwW-4wn9A:
undetectable		 2zxwP-4wn9A:
17.15
2zxwW-4wn9A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x00 PUTATIVE HYDROLASE

(Burkholderia
cenocepacia) 		PF12697
(Abhydrolase_6) 		4 LEU A  59
GLN A  60
LEU A 273
PHE A 269
 None
 0.74A 2zxwP-4x00A:
undetectable
2zxwW-4x00A:
undetectable		 2zxwP-4x00A:
21.50
2zxwW-4x00A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 LEU A 524
GLN A 526
PHE A 525
LEU A 502
 None
 1.01A 2zxwP-4xgtA:
undetectable
2zxwW-4xgtA:
undetectable		 2zxwP-4xgtA:
12.69
2zxwW-4xgtA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y99 TROPONIN T, CARDIAC
MUSCLE
TROPONIN I, CARDIAC
MUSCLE

(Homo sapiens;
Homo sapiens) 		PF00992
(Troponin)
PF00992
(Troponin)
PF11636
(Troponin-I_N) 		4 ARG C 111
LEU B 250
GLN B 251
PHE B 254
 None
 0.99A 2zxwP-4y99C:
undetectable
2zxwW-4y99C:
3.1		 2zxwP-4y99C:
15.15
2zxwW-4y99C:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 LEU A 229
GLN A 228
PHE A 227
LEU A 211
 None
 0.99A 2zxwP-4z61A:
undetectable
2zxwW-4z61A:
undetectable		 2zxwP-4z61A:
16.59
2zxwW-4z61A:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bza BETA-N-ACETYLHEXOSAM
INIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3) 		4 LEU A 463
GLN A 460
PHE A 459
LEU A 343
 None
 1.03A 2zxwP-5bzaA:
undetectable
2zxwW-5bzaA:
undetectable		 2zxwP-5bzaA:
17.12
2zxwW-5bzaA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c4y PUTATIVE
TRANSCRIPTION
REGULATOR LMO0852

(Listeria
monocytogenes) 		PF00440
(TetR_N) 		4 LEU A  79
GLN A  80
PHE A  83
LEU A 133
 None
 0.92A 2zxwP-5c4yA:
2.2
2zxwW-5c4yA:
undetectable		 2zxwP-5c4yA:
23.66
2zxwW-5c4yA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG

(Homo sapiens) 		PF00632
(HECT) 		4 LEU A 649
PHE A 650
LEU A 781
PHE A 773
 None
 1.01A 2zxwP-5c7mA:
undetectable
2zxwW-5c7mA:
undetectable		 2zxwP-5c7mA:
19.45
2zxwW-5c7mA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9h TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		PF12009
(Telomerase_RBD) 		4 GLN A 382
PHE A 379
LEU A 405
PHE A 401
 None
 0.78A 2zxwP-5c9hA:
undetectable
2zxwW-5c9hA:
undetectable		 2zxwP-5c9hA:
18.61
2zxwW-5c9hA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		4 LEU A1278
GLN A1279
PHE A1276
LEU A1301
 None
 0.77A 2zxwP-5d0fA:
undetectable
2zxwW-5d0fA:
undetectable		 2zxwP-5d0fA:
10.41
2zxwW-5d0fA:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza C
virus) 		PF00602
(Flu_PB1) 		4 LEU B 442
GLN B 443
LEU B 284
PHE B 498
 None
 1.00A 2zxwP-5d9aB:
undetectable
2zxwW-5d9aB:
undetectable		 2zxwP-5d9aB:
16.47
2zxwW-5d9aB:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du9 CDA PEPTIDE
SYNTHETASE I

(Streptomyces
coelicolor) 		PF00668
(Condensation) 		4 LEU A 423
GLN A 424
PHE A 427
LEU A 229
 None
 0.73A 2zxwP-5du9A:
undetectable
2zxwW-5du9A:
undetectable		 2zxwP-5du9A:
20.97
2zxwW-5du9A:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
ALPHA TYPE 2,
PUTATIVE

(Plasmodium
falciparum) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		4 LEU B 134
GLN B 148
LEU B  86
PHE B 130
 None
 0.98A 2zxwP-5fmgB:
undetectable
2zxwW-5fmgB:
undetectable		 2zxwP-5fmgB:
18.82
2zxwW-5fmgB:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn3 PRESENILIN-1

(Homo sapiens) 		PF01080
(Presenilin) 		4 LEU B 392
PHE B 388
LEU B 443
PHE B 447
 None
 0.95A 2zxwP-5fn3B:
2.1
2zxwW-5fn3B:
undetectable		 2zxwP-5fn3B:
20.04
2zxwW-5fn3B:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu6 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 3

(Homo sapiens) 		PF04153
(NOT2_3_5) 		4 LEU C 671
PHE C 673
LEU C 666
PHE C 662
 None
 0.94A 2zxwP-5fu6C:
undetectable
2zxwW-5fu6C:
undetectable		 2zxwP-5fu6C:
18.59
2zxwW-5fu6C:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4q DNA POLYMERASE III
SUBUNIT BETA

(Helicobacter
pylori) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 LEU A 183
GLN A 182
LEU A 134
PHE A 138
 None
 0.74A 2zxwP-5g4qA:
undetectable
2zxwW-5g4qA:
undetectable		 2zxwP-5g4qA:
20.21
2zxwW-5g4qA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE

(Thermococcus
kodakarensis) 		PF02449
(Glyco_hydro_42) 		4 LEU A  25
GLN A  26
PHE A  27
LEU A  39
 None
 0.99A 2zxwP-5gsmA:
undetectable
2zxwW-5gsmA:
undetectable		 2zxwP-5gsmA:
16.50
2zxwW-5gsmA:
6.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iy5 CYTOCHROME C OXIDASE
SUBUNIT 3

(Bos taurus) 		PF00510
(COX3) 		5 ARG C 156
LEU C 160
GLN C 161
PHE C 164
LEU C 223
 CHD  C 307 (-4.0A)
CHD  C 307 ( 3.9A)
CHD  C 307 (-4.3A)
CHD  C 307 (-3.9A)
None
 0.34A 2zxwP-5iy5C:
37.2
2zxwW-5iy5C:
undetectable		 2zxwP-5iy5C:
100.00
2zxwW-5iy5C:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 4 LEU A 135
GLN A 134
PHE A 133
LEU A 151
 None
 1.03A 2zxwP-5mjsA:
undetectable
2zxwW-5mjsA:
undetectable		 2zxwP-5mjsA:
undetectable
2zxwW-5mjsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		4 LEU A 446
GLN A 447
LEU A 408
PHE A 412
 None
 0.94A 2zxwP-5t8vA:
3.1
2zxwW-5t8vA:
undetectable		 2zxwP-5t8vA:
9.66
2zxwW-5t8vA:
3.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td7 ZGC:55652

(Danio rerio) 		PF00850
(Hist_deacetyl) 		4 ARG A 660
LEU A 661
GLN A 662
LEU A 547
 None
 0.97A 2zxwP-5td7A:
undetectable
2zxwW-5td7A:
undetectable		 2zxwP-5td7A:
17.28
2zxwW-5td7A:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufl PROTEIN CIP2A

(Homo sapiens) 		no annotation 4 LEU A 237
GLN A 236
PHE A 239
LEU A 209
 None
 0.83A 2zxwP-5uflA:
undetectable
2zxwW-5uflA:
undetectable		 2zxwP-5uflA:
19.09
2zxwW-5uflA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvn PARAQUAT-INDUCIBLE
PROTEIN B

(Escherichia
coli) 		PF02470
(MlaD) 		4 LEU A 202
GLN A 201
PHE A 203
PHE A 250
 None
 1.03A 2zxwP-5uvnA:
undetectable
2zxwW-5uvnA:
undetectable		 2zxwP-5uvnA:
20.54
2zxwW-5uvnA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5viq MONOMERIC
NEAR-INFRARED
FLUORESCENT PROTEIN
MIRFP709

(Rhodopseudomonas
palustris) 		PF01590
(GAF)
PF08446
(PAS_2) 		4 LEU A 255
GLN A 256
PHE A 257
LEU A 218
 None
None
BLA  A 401 (-4.3A)
None
 0.93A 2zxwP-5viqA:
undetectable
2zxwW-5viqA:
undetectable		 2zxwP-5viqA:
19.88
2zxwW-5viqA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3r LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Vibrio
vulnificus) 		no annotation 4 GLN A 141
PHE A 144
LEU A  79
PHE A  75
 None
None
None
7Y3  A 601 (-4.3A)
 0.98A 2zxwP-5x3rA:
undetectable
2zxwW-5x3rA:
undetectable		 2zxwP-5x3rA:
undetectable
2zxwW-5x3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xge UNCHARACTERIZED
PROTEIN PA0861

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A 658
GLN A 659
PHE A 660
LEU A 698
 None
 1.04A 2zxwP-5xgeA:
undetectable
2zxwW-5xgeA:
undetectable		 2zxwP-5xgeA:
undetectable
2zxwW-5xgeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhx HELIX-TURN-HELIX
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A 141
GLN A 128
LEU A  30
PHE A  26
 None
 0.94A 2zxwP-5xhxA:
undetectable
2zxwW-5xhxA:
undetectable		 2zxwP-5xhxA:
21.93
2zxwW-5xhxA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT

(Komagataella
phaffii) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 LEU A 868
GLN A 866
PHE A 867
LEU A1002
 None
 0.84A 2zxwP-5xogA:
3.9
2zxwW-5xogA:
undetectable		 2zxwP-5xogA:
9.55
2zxwW-5xogA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 4 GLN A 378
PHE A 387
LEU A 366
PHE A 649
 None
PGE  A 703 (-4.4A)
EE4  A 701 ( 4.6A)
None
 0.90A 2zxwP-6c0tA:
1.7
2zxwW-6c0tA:
undetectable		 2zxwP-6c0tA:
undetectable
2zxwW-6c0tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c29 PUTATIVE METAL
RESISTANCE PROTEIN

(Proteus
mirabilis) 		no annotation 4 LEU A 167
GLN A 166
LEU A 227
PHE A 229
 None
 1.00A 2zxwP-6c29A:
undetectable
2zxwW-6c29A:
undetectable		 2zxwP-6c29A:
undetectable
2zxwW-6c29A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfp UBIQUITIN-LIKE
PROTEIN
SMT3,POLYMERASE
ACIDIC PROTEIN

(Saccharomyces
cerevisiae;
Influenza A
virus) 		no annotation 4 LEU A 694
GLN A 654
LEU A 268
PHE A 707
 None
 1.02A 2zxwP-6cfpA:
undetectable
2zxwW-6cfpA:
undetectable		 2zxwP-6cfpA:
undetectable
2zxwW-6cfpA:
undetectable