SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZW9_B_SAMB801_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnv CONCANAVALIN B

(Canavalia
ensiformis)
PF00704
(Glyco_hydro_18)
4 ILE A 279
ASN A  27
ASP A 270
TYR A 275
None
1.12A 2zw9B-1cnvA:
undetectable
2zw9B-1cnvA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exf EXFOLIATVE TOXIN A

(Staphylococcus
aureus)
PF13365
(Trypsin_2)
4 ASN A 194
SER A 197
ASP A 144
SER A  41
None
1.03A 2zw9B-1exfA:
undetectable
2zw9B-1exfA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzo BETA-LACTAMASE

(Proteus
vulgaris)
PF13354
(Beta-lactamase2)
4 ILE A 247
SER A 130
TYR A 264
SER A  72
None
MES  A1000 (-2.7A)
None
None
1.00A 2zw9B-1hzoA:
undetectable
2zw9B-1hzoA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5m SIR4-INTERACTING
PROTEIN SIF2


(Saccharomyces
cerevisiae)
PF00400
(WD40)
PF12894
(ANAPC4_WD40)
4 ILE A 445
SER A 363
ASP A 421
SER A 417
None
1.16A 2zw9B-1r5mA:
6.5
2zw9B-1r5mA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua7 ALPHA-AMYLASE

(Bacillus
subtilis)
PF00128
(Alpha-amylase)
4 ILE A 235
SER A 278
ARG A 306
TYR A 231
None
1.15A 2zw9B-1ua7A:
undetectable
2zw9B-1ua7A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE


(Thermus
thermophilus)
PF13561
(adh_short_C2)
4 ASN A 108
SER A 151
TYR A  84
SER A 136
None
1.09A 2zw9B-1ulsA:
5.4
2zw9B-1ulsA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE


(Mycobacterium
tuberculosis)
PF13561
(adh_short_C2)
4 ILE A 138
ASN A 112
SER A 156
SER A 140
None
1.14A 2zw9B-1uznA:
5.3
2zw9B-1uznA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytm PHOSPHOENOLPYRUVATE
CARBOXYKINASE [ATP]


(Anaerobiospirillum
succiniciproducens)
PF01293
(PEPCK_ATP)
4 ILE A 452
ASN A 434
SER A 355
SER A 366
None
1.04A 2zw9B-1ytmA:
undetectable
2zw9B-1ytmA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3v CELLULASE

(Phanerochaete
chrysosporium)
PF00840
(Glyco_hydro_7)
4 ILE A 363
ASN A 214
LYS A 265
SER A 411
None
0.89A 2zw9B-1z3vA:
undetectable
2zw9B-1z3vA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbh 3'-5' EXONUCLEASE
ERI1


(Homo sapiens)
PF00929
(RNase_T)
PF02037
(SAP)
4 ILE A 318
ASN A 259
SER A 232
SER A 329
None
None
None
C  F  20 ( 3.3A)
1.09A 2zw9B-1zbhA:
undetectable
2zw9B-1zbhA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi7 UDP-GALACTOPYRANOSE
MUTASE


(Klebsiella
pneumoniae)
PF03275
(GLF)
PF13450
(NAD_binding_8)
4 ILE A 205
SER A  42
TYR A  72
SER A  14
None
FAD  A1385 ( 3.8A)
None
FAD  A1385 (-2.6A)
0.97A 2zw9B-2bi7A:
undetectable
2zw9B-2bi7A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpa PROTEIN (SUBUNIT OF
BACTERIOPHAGE
PHIX174)


(Escherichia
virus phiX174)
PF02305
(Phage_F)
4 ILE 1 219
ASP 1 231
TYR 1 215
SER 1 227
None
1.09A 2zw9B-2bpa1:
undetectable
2zw9B-2bpa1:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c07 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE


(Plasmodium
falciparum)
PF13561
(adh_short_C2)
4 ILE A 197
ASN A 171
SER A 215
SER A 199
None
1.09A 2zw9B-2c07A:
5.8
2zw9B-2c07A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrb CARBONYL REDUCTASE
[NADPH] 3


(Homo sapiens)
PF00106
(adh_short)
4 ILE A 138
ASN A 114
SER A 197
SER A 140
NAP  A1001 (-4.2A)
None
None
NAP  A1001 ( 4.0A)
1.14A 2zw9B-2hrbA:
5.8
2zw9B-2hrbA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsd 3-ALPHA, 20
BETA-HYDROXYSTEROID
DEHYDROGENASE


(Streptomyces
exfoliatus)
PF13561
(adh_short_C2)
4 ILE A 137
ASN A 111
SER A 155
SER A 139
NAD  A 256 (-4.6A)
None
None
NAD  A 256 (-3.4A)
1.11A 2zw9B-2hsdA:
5.8
2zw9B-2hsdA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i71 HYPOTHETICAL PROTEIN

(Sulfolobus
solfataricus)
PF09455
(Cas_DxTHG)
4 ILE A  22
SER A  29
ASP A 125
TYR A 161
None
1.13A 2zw9B-2i71A:
1.8
2zw9B-2i71A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k75 UNCHARACTERIZED
PROTEIN TA0387


(Thermoplasma
acidophilum)
no annotation 4 ILE A  68
ASN A  70
SER A  87
SER A  83
None
0.87A 2zw9B-2k75A:
undetectable
2zw9B-2k75A:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1)
PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C)
4 ILE A 195
SER A 529
ARG A 502
ASP A  74
None
1.10A 2zw9B-2okxA:
undetectable
2zw9B-2okxA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE


(Thermus
thermophilus)
PF13561
(adh_short_C2)
4 ILE A 137
ASN A 111
SER A 155
SER A 139
None
1.06A 2zw9B-2ph3A:
5.1
2zw9B-2ph3A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsa MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus)
PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2)
4 ILE A  64
ASN A 860
SER A 735
SER A  66
None
1.08A 2zw9B-2vsaA:
undetectable
2zw9B-2vsaA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyx BETA-LACTAMSE TOHO-1

(Escherichia
coli)
PF13354
(Beta-lactamase2)
4 ILE A 247
SER A 130
TYR A 264
SER A  72
None
0.96A 2zw9B-2wyxA:
undetectable
2zw9B-2wyxA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzf GLUCOSYLTRANSFERASE

(Legionella
pneumophila)
PF16849
(Glyco_transf_88)
4 ILE A 297
ASN A 293
ARG A 502
ASP A 246
None
BGC  A1526 (-3.0A)
None
BGC  A1526 (-2.7A)
1.08A 2zw9B-2wzfA:
undetectable
2zw9B-2wzfA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE


(Streptococcus
pneumoniae)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF03714
(PUD)
4 ILE A 335
ASN A 347
SER A 237
ASP A 353
None
None
None
NA  A2157 (-3.9A)
1.12A 2zw9B-2ya1A:
undetectable
2zw9B-2ya1A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zoa PHOSPHOHYDROLASE

(Klebsiella
aerogenes)
PF00149
(Metallophos)
4 ILE A  51
SER A 121
ASP A   8
SER A  48
None
None
FE2  A 275 ( 3.1A)
None
1.01A 2zw9B-2zoaA:
2.1
2zw9B-2zoaA:
16.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2


(Saccharomyces
cerevisiae)
PF04072
(LCM)
PF13418
(Kelch_4)
8 ILE A  27
ASN A  31
SER A  34
LYS A  38
ARG A  88
ASP A 146
TYR A 147
SER A 226
SAH  A 801 (-4.4A)
SAH  A 801 (-4.6A)
SAH  A 801 (-3.6A)
SAH  A 801 (-2.8A)
SAH  A 801 (-3.9A)
SAH  A 801 (-2.9A)
SAH  A 801 (-3.8A)
SAH  A 801 (-4.6A)
0.31A 2zw9B-2zwaA:
56.8
2zw9B-2zwaA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN


(Pyrobaculum
aerophilum)
PF07995
(GSDH)
4 ILE A 342
SER A  39
ASP A 339
SER A 367
None
1.05A 2zw9B-3a9gA:
1.7
2zw9B-3a9gA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfg CLASS A
BETA-LACTAMASE SED1


(Citrobacter
sedlakii)
PF13354
(Beta-lactamase2)
4 ILE A 247
SER A 130
TYR A 264
SER A  72
None
MER  A 301 (-2.6A)
None
None
0.95A 2zw9B-3bfgA:
undetectable
2zw9B-3bfgA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bsf AT4G34840

(Arabidopsis
thaliana)
PF01048
(PNP_UDP_1)
4 ILE A  93
ASN A  60
SER A  14
ARG A  11
None
1.16A 2zw9B-3bsfA:
undetectable
2zw9B-3bsfA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeg 2-ISOPROPYLMALATE
SYNTHASE


(Cytophaga
hutchinsonii)
PF00682
(HMGL-like)
4 ILE A  83
SER A  57
LYS A  28
SER A  50
None
1.05A 2zw9B-3eegA:
undetectable
2zw9B-3eegA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emk GLUCOSE/RIBITOL
DEHYDROGENASE


(Brucella
melitensis)
PF13561
(adh_short_C2)
4 ILE A 137
ASN A 111
SER A 155
SER A 139
None
1.06A 2zw9B-3emkA:
5.7
2zw9B-3emkA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fed GLUTAMATE
CARBOXYPEPTIDASE III


(Homo sapiens)
PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28)
4 ILE A 440
SER A 436
ARG A 663
SER A 522
None
1.09A 2zw9B-3fedA:
undetectable
2zw9B-3fedA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzy RTX TOXIN RTXA

(Vibrio cholerae)
PF11713
(Peptidase_C80)
4 ILE A3584
LYS A3511
ARG A3457
SER A3632
UNX  A 327 (-4.3A)
CL  A   1 ( 4.2A)
IHP  A8000 ( 4.0A)
None
1.05A 2zw9B-3fzyA:
undetectable
2zw9B-3fzyA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcd RTX TOXIN RTXA

(Vibrio cholerae)
PF11713
(Peptidase_C80)
4 ILE A 156
LYS A  83
ARG A  29
SER A 204
None
None
IHP  A 214 (-4.0A)
None
0.99A 2zw9B-3gcdA:
undetectable
2zw9B-3gcdA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE


(Haemophilus
influenzae)
PF02395
(Peptidase_S6)
PF03212
(Pertactin)
4 ILE A  86
SER A 137
TYR A 239
SER A 102
None
1.03A 2zw9B-3h09A:
undetectable
2zw9B-3h09A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4r EXODEOXYRIBONUCLEASE
8


(Escherichia
coli)
PF12684
(DUF3799)
4 ILE A 614
ASN A 835
TYR A 629
SER A 617
None
1.10A 2zw9B-3h4rA:
undetectable
2zw9B-3h4rA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzs MONOFUNCTIONAL
GLYCOSYLTRANSFERASE


(Staphylococcus
aureus)
PF00912
(Transgly)
4 ILE A  97
SER A 221
ARG A 241
TYR A 254
None
1.05A 2zw9B-3hzsA:
undetectable
2zw9B-3hzsA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1


(Cryptosporidium
parvum)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
4 ILE A 456
ASP A 131
TYR A 452
SER A 374
None
1.01A 2zw9B-3igoA:
undetectable
2zw9B-3igoA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuu PUTATIVE
METALLOPEPTIDASE


(Chelativorans
sp. BNC1)
PF07171
(MlrC_C)
PF07364
(DUF1485)
4 ILE A 154
ASP A 226
TYR A 248
SER A 156
None
1.15A 2zw9B-3iuuA:
undetectable
2zw9B-3iuuA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr3 NAD-DEPENDENT
DEACETYLASE


(Thermotoga
maritima)
PF02146
(SIR2)
4 ILE A  50
ASN A  46
SER A  44
SER A  55
None
1.09A 2zw9B-3jr3A:
2.4
2zw9B-3jr3A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khd PYRUVATE KINASE

(Plasmodium
falciparum)
PF00224
(PK)
PF02887
(PK_C)
4 ILE A 396
ASN A 312
TYR A 438
SER A 391
None
1.10A 2zw9B-3khdA:
undetectable
2zw9B-3khdA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhl PUTATIVE AGMATINASE

(Clostridioides
difficile)
PF00491
(Arginase)
4 ILE A  97
ASN A  22
TYR A  18
SER A 101
None
1.06A 2zw9B-3lhlA:
3.4
2zw9B-3lhlA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq0 PROASTACIN

(Astacus astacus)
PF01400
(Astacin)
4 ILE A   4
LYS A 179
TYR A  13
SER A 153
None
1.10A 2zw9B-3lq0A:
undetectable
2zw9B-3lq0A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)


(Aquifex
aeolicus)
PF00158
(Sigma54_activat)
4 ILE A 165
ASN A 280
SER A 169
ARG A 357
None
ATP  A 400 (-4.2A)
ATP  A 400 (-2.6A)
ATP  A 400 (-3.3A)
1.02A 2zw9B-3m0eA:
2.5
2zw9B-3m0eA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2e SHIKIMATE KINASE

(Helicobacter
pylori)
PF01202
(SKI)
4 ILE A  82
SER A  12
ASP A  33
SER A  77
None
0.99A 2zw9B-3n2eA:
undetectable
2zw9B-3n2eA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne8 N-ACETYLMURAMOYL-L-A
LANINE AMIDASE


(Bartonella
henselae)
PF01520
(Amidase_3)
4 ASN A 329
SER A 332
LYS A 336
TYR A 401
GOL  A 413 ( 4.0A)
None
None
GOL  A 413 ( 4.9A)
1.02A 2zw9B-3ne8A:
undetectable
2zw9B-3ne8A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1


(Anopheles
gambiae)
PF13855
(LRR_8)
4 ASN B 391
ARG B 621
ASP B 387
SER B 413
None
1.11A 2zw9B-3ojaB:
undetectable
2zw9B-3ojaB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis)
no annotation 4 ILE A 164
ASN A 129
SER A 131
SER A 169
None
MG  A 325 ( 4.8A)
None
None
1.11A 2zw9B-3p4gA:
undetectable
2zw9B-3p4gA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4d MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY
POSSIBLE
CHLOROMUCONATE
CYCLOISOMERASE


(Cytophaga
hutchinsonii)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ILE A  98
ASN A 103
SER A  85
SER A  96
None
1.11A 2zw9B-3q4dA:
undetectable
2zw9B-3q4dA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qjg EPIDERMIN
BIOSYNTHESIS PROTEIN
EPID


(Staphylococcus
aureus)
PF02441
(Flavoprotein)
4 ILE A 112
ASN A 115
SER A  12
SER A  84
None
FMN  A 501 (-4.2A)
FMN  A 501 (-2.6A)
None
0.94A 2zw9B-3qjgA:
2.9
2zw9B-3qjgA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm2 PHOSPHOSERINE
AMINOTRANSFERASE


(Salmonella
enterica)
PF00266
(Aminotran_5)
4 ILE A 159
ASN A 151
SER A 177
LYS A 198
None
1.09A 2zw9B-3qm2A:
undetectable
2zw9B-3qm2A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp6 CVIR TRANSCRIPTIONAL
REGULATOR


(Chromobacterium
violaceum)
PF00196
(GerE)
PF03472
(Autoind_bind)
4 ILE A  69
ASN A  67
ARG A  10
SER A 152
None
1.04A 2zw9B-3qp6A:
undetectable
2zw9B-3qp6A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sju KETO REDUCTASE

(Streptomyces
griseoruber)
PF00106
(adh_short)
4 ILE A 140
ASN A 112
SER A 158
SER A 142
NDP  A 301 (-4.3A)
None
None
NDP  A 301 (-3.7A)
1.09A 2zw9B-3sjuA:
undetectable
2zw9B-3sjuA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thz DNA MISMATCH REPAIR
PROTEIN MSH2


(Homo sapiens)
PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III)
4 SER A 284
ARG A 171
TYR A 121
SER A 129
None
1.10A 2zw9B-3thzA:
undetectable
2zw9B-3thzA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsc PUTATIVE
OXIDOREDUCTASE


(Mycobacterium
avium)
PF13561
(adh_short_C2)
4 ILE A 155
ASN A 128
SER A 173
SER A 157
NAD  A 274 (-4.6A)
None
None
NAD  A 274 (-3.6A)
1.06A 2zw9B-3tscA:
2.5
2zw9B-3tscA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uf0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR


(Beutenbergia
cavernae)
PF13561
(adh_short_C2)
4 ILE A 141
ASN A 115
SER A 159
SER A 143
NAP  A 274 (-4.3A)
None
None
NAP  A 274 (-3.5A)
1.15A 2zw9B-3uf0A:
5.4
2zw9B-3uf0A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqo UNCHARACTERIZED
PROTEIN MJ1311


(Methanocaldococcus
jannaschii)
PF01261
(AP_endonuc_2)
4 ILE A 148
ASN A 186
SER A 184
TYR A 152
None
1.03A 2zw9B-3wqoA:
undetectable
2zw9B-3wqoA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxb UNCHARACTERIZED
PROTEIN


(Gallus gallus)
PF00106
(adh_short)
4 ILE A 157
ASN A 120
SER A 181
SER A 159
NDP  A 300 (-4.4A)
None
None
EDO  A 301 ( 2.5A)
1.14A 2zw9B-3wxbA:
6.5
2zw9B-3wxbA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zny CTX-M-12A ENZYME

(Klebsiella
pneumoniae)
PF13354
(Beta-lactamase2)
4 ILE A 247
SER A 130
TYR A 264
SER A  72
None
0.92A 2zw9B-3znyA:
undetectable
2zw9B-3znyA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b97 CELLULOSE BINDING
DOMAIN-CONTAINING
PROTEIN


(Ruminiclostridium
thermocellum)
PF00942
(CBM_3)
4 ILE A  47
ASN A 117
ASP A 121
TYR A  45
None
None
CA  A1152 (-2.9A)
None
0.97A 2zw9B-4b97A:
undetectable
2zw9B-4b97A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cql ESTRADIOL
17-BETA-DEHYDROGENAS
E 8


(Homo sapiens)
PF13561
(adh_short_C2)
4 ILE A 154
ASN A 127
SER A 172
SER A 156
NAD  A 301 (-4.6A)
None
None
NAD  A 301 (-3.1A)
1.00A 2zw9B-4cqlA:
5.4
2zw9B-4cqlA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyv HEMAGGLUTININ

(Influenza A
virus)
PF00509
(Hemagglutinin)
4 ILE B 152
ASN B 154
TYR B 157
SER B 147
None
NAG  B 211 (-1.9A)
None
None
1.11A 2zw9B-4cyvB:
undetectable
2zw9B-4cyvB:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fda 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE


(Saccharomyces
cerevisiae)
PF00106
(adh_short)
4 ILE A 181
ASN A 144
SER A 201
SER A 183
None
None
None
NAP  A 301 (-3.3A)
1.14A 2zw9B-4fdaA:
undetectable
2zw9B-4fdaA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhr ALPHA-DIOXYGENASE

(Arabidopsis
thaliana)
PF03098
(An_peroxidase)
4 ILE A 320
ASN A 339
ARG A 566
TYR A 341
None
None
CL  A 711 (-3.3A)
None
1.05A 2zw9B-4hhrA:
undetectable
2zw9B-4hhrA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5j SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT ALPHA


(Homo sapiens)
PF13499
(EF-hand_7)
4 ILE A 249
ASN A 237
SER A 239
SER A 191
None
1.13A 2zw9B-4i5jA:
undetectable
2zw9B-4i5jA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iop C-TYPE LECTIN DOMAIN
FAMILY 2 MEMBER A
KILLER CELL
LECTIN-LIKE RECEPTOR
SUBFAMILY F MEMBER 2


(Homo sapiens;
Homo sapiens)
PF00059
(Lectin_C)
PF00059
(Lectin_C)
4 ILE A 140
ASN A 143
SER B 187
SER A 145
None
1.10A 2zw9B-4iopA:
undetectable
2zw9B-4iopA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuy SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE


(Acinetobacter
baumannii)
PF00106
(adh_short)
4 ILE A 144
ASN A 117
SER A 162
SER A 146
None
0.99A 2zw9B-4iuyA:
6.6
2zw9B-4iuyA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1


(Arabidopsis
thaliana)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8)
4 ILE A 363
ASN A 344
SER A 370
SER A 366
None
1.10A 2zw9B-4j0mA:
undetectable
2zw9B-4j0mA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1y COMPLEMENT C1S
SUBCOMPONENT


(Homo sapiens)
PF00084
(Sushi)
PF00089
(Trypsin)
4 ILE A 617
SER A 627
ARG A 572
SER A 654
None
1.14A 2zw9B-4j1yA:
undetectable
2zw9B-4j1yA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvl FATTY ACID
ALPHA-OXIDASE


(Oryza sativa)
PF03098
(An_peroxidase)
4 ILE A 313
ASN A 332
ARG A 559
TYR A 334
None
PLM  A 702 ( 3.6A)
PLM  A 702 (-2.9A)
None
1.02A 2zw9B-4kvlA:
undetectable
2zw9B-4kvlA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le4 BETA-GLUCANASE

(Podospora
anserina)
no annotation 4 ASN A 182
SER A 199
ASP A  73
SER A 257
None
0.95A 2zw9B-4le4A:
undetectable
2zw9B-4le4A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n8g TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Chromohalobacter
salexigens)
PF03480
(DctP)
4 ILE A 106
SER A 241
ASP A 180
SER A  95
None
DAL  A 402 (-2.8A)
None
DAL  A 403 ( 4.7A)
1.03A 2zw9B-4n8gA:
undetectable
2zw9B-4n8gA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10


(Homo sapiens)
PF00211
(Guanylate_cyc)
4 ILE A 407
ASN A 412
ARG A 176
SER A  49
None
None
1VE  A 501 (-3.2A)
None
1.04A 2zw9B-4oyaA:
undetectable
2zw9B-4oyaA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdx PUTATIVE
ALKYL/ARYL-SULFATASE
YJCS


(Escherichia
coli)
PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C)
4 ILE A 396
ASN A 394
ARG A 477
SER A 420
None
1.13A 2zw9B-4pdxA:
undetectable
2zw9B-4pdxA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkm MCCA

(Wolinella
succinogenes)
no annotation 4 ASN A 104
SER A 107
ARG A 112
SER A 120
None
1.00A 2zw9B-4rkmA:
undetectable
2zw9B-4rkmA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvo MALATE DEHYDROGENASE

(Mycobacterium
tuberculosis)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
4 ILE A 282
ASN A 188
SER A 313
SER A 284
None
1.03A 2zw9B-4tvoA:
4.4
2zw9B-4tvoA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzf FAB FRAGMENT OF
IMMUNOGLOBULIN (IGG)
MOLECULE


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 ILE E  84
SER E  72
TYR E  95
SER E  19
None
1.09A 2zw9B-4yzfE:
undetectable
2zw9B-4yzfE:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4za2 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE


(Pectobacterium
carotovorum)
PF13561
(adh_short_C2)
4 ILE A 143
ASN A 116
SER A 161
SER A 145
None
1.15A 2zw9B-4za2A:
5.9
2zw9B-4za2A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo4 DEPHOSPHO-COA KINASE

(Campylobacter
jejuni)
PF01121
(CoaE)
4 ILE A  21
ASN A  23
SER A  29
SER A  16
None
0.99A 2zw9B-4zo4A:
undetectable
2zw9B-4zo4A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao8 SOLUBLE LYTIC
TRANGLYCOSILASE B3


(Pseudomonas
aeruginosa)
PF01471
(PG_binding_1)
PF13406
(SLT_2)
4 ILE A 324
ASN A 328
ARG A  95
SER A 331
None
NAG  A 999 (-4.0A)
None
None
1.12A 2zw9B-5ao8A:
undetectable
2zw9B-5ao8A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4x REELIN

(Mus musculus)
PF07974
(EGF_2)
4 ASN A2317
SER A2319
ASP A2168
SER A2222
NAG  A4005 (-1.9A)
NAG  A4005 (-3.2A)
NAG  A4005 (-4.0A)
None
1.15A 2zw9B-5b4xA:
undetectable
2zw9B-5b4xA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1


(Chaetomium
thermophilum)
PF00400
(WD40)
PF08154
(NLE)
4 ILE A 100
SER A 403
ARG A 419
SER A  98
None
1.00A 2zw9B-5cykA:
7.9
2zw9B-5cykA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN ALPHA-L

(Homo sapiens)
PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
4 ILE A 126
ASN A 129
SER A 165
ASP A  95
None
1.09A 2zw9B-5e6sA:
1.4
2zw9B-5e6sA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwt 4-HYDROXYISOLECUINE
DEHYDROGENASE


(Bacillus
thuringiensis)
no annotation 4 ILE A 135
ASN A 108
SER A 153
SER A 137
NAD  A 301 (-4.3A)
None
None
SIN  A 302 ( 2.4A)
1.14A 2zw9B-5gwtA:
5.5
2zw9B-5gwtA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)


(Naja atra)
PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest)
4 ILE A 722
ASN A 583
SER A 579
SER A 607
None
1.07A 2zw9B-5gz4A:
undetectable
2zw9B-5gz4A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ifz RIBOSE 5-PHOSPHATE
ISOMERASE


(Brucella
melitensis)
PF02502
(LacAB_rpiB)
4 ILE A 117
ASN A 112
SER A 111
SER A 104
None
1.02A 2zw9B-5ifzA:
undetectable
2zw9B-5ifzA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkq PFVFT1

(Plasmodium
falciparum)
no annotation 4 ILE A 274
SER A 288
ASP A  61
SER A 272
None
1.13A 2zw9B-5jkqA:
undetectable
2zw9B-5jkqA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis)
no annotation 4 ILE A  19
SER A 107
ASP A  16
SER A 103
None
None
CA  A 609 (-2.9A)
CA  A 610 ( 4.8A)
1.09A 2zw9B-5k8gA:
undetectable
2zw9B-5k8gA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63)
4 ILE A1763
ASN A1755
SER A1854
SER A1761
None
1.11A 2zw9B-5m5pA:
3.2
2zw9B-5m5pA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mln ALCOHOL
DEHYDROGENASE 3


([Candida]
magnoliae)
no annotation 4 ILE A 142
ASN A 113
SER A 160
SER A 144
NAP  A 301 (-4.6A)
None
None
NAP  A 301 (-3.5A)
1.13A 2zw9B-5mlnA:
5.2
2zw9B-5mlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o98 ALCOHOL
DEHYDROGENASE 1


(Catharanthus
roseus)
no annotation 4 ILE A 165
ASN A 139
SER A 226
SER A 167
NAP  A 501 (-4.4A)
None
None
NAP  A 501 ( 4.3A)
1.16A 2zw9B-5o98A:
5.5
2zw9B-5o98A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8u LIPOATE-PROTEIN
LIGASE 1


(Plasmodium
falciparum)
PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C)
4 ILE A  32
ASN A  29
SER A  27
SER A  37
None
1.14A 2zw9B-5t8uA:
undetectable
2zw9B-5t8uA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thw DEACYLASE

(Burkholderia
multivorans)
PF01546
(Peptidase_M20)
4 ILE A 137
SER A 153
ASP A  98
SER A  95
None
None
None
ZN  A 501 ( 4.9A)
1.12A 2zw9B-5thwA:
undetectable
2zw9B-5thwA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpc BOTULINUM NEUROTOXIN
TYPE A


(Clostridium
botulinum)
PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N)
4 ILE A 878
ASN A1073
SER A 944
ASP A 875
None
1.12A 2zw9B-5tpcA:
undetectable
2zw9B-5tpcA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w11 GLUCANASE

(Thermothelomyces
thermophila)
no annotation 4 ILE A 371
ASN A 220
LYS A 277
SER A 418
None
1.06A 2zw9B-5w11A:
undetectable
2zw9B-5w11A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y31 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 22


(Homo sapiens)
no annotation 4 ILE A 707
ASN A 712
SER A 689
SER A 709
None
0.92A 2zw9B-5y31A:
undetectable
2zw9B-5y31A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ys6 PRV GLYCOPROTEN B

(Suid
alphaherpesvirus
1)
no annotation 4 ASN A 354
ARG A 373
TYR A 325
SER A 309
None
1.15A 2zw9B-5ys6A:
undetectable
2zw9B-5ys6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z8o CYCLASE/DEHYDRASE

(Mycolicibacterium
smegmatis)
no annotation 4 ILE A  73
ASN A  71
TYR A  67
SER A  16
None
1.11A 2zw9B-5z8oA:
undetectable
2zw9B-5z8oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bu3 BETA-LACTAMASE

(Escherichia
coli)
no annotation 4 ILE A 247
SER A 130
TYR A 264
SER A  72
None
3GK  A 301 (-2.7A)
None
None
0.93A 2zw9B-6bu3A:
undetectable
2zw9B-6bu3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d9y SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR


(Paraburkholderia
phymatum)
no annotation 4 ILE A 142
ASN A 116
SER A 160
SER A 144
None
1.09A 2zw9B-6d9yA:
6.4
2zw9B-6d9yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE BASIC
PROTEIN 2


(Influenza B
virus)
no annotation 4 ILE C 269
SER C 524
ASP C 307
SER C 520
None
1.12A 2zw9B-6f5oC:
undetectable
2zw9B-6f5oC:
undetectable