SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZW9_A_SAMA801_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7g TYROSINE
PHENOL-LYASE

(Pantoea
agglomerans) 		PF01212
(Beta_elim_lyase) 		4 THR A 402
LEU A 405
ASP A  50
GLU A 338
 None
 1.07A 2zw9A-1c7gA:
2.8		 2zw9A-1c7gA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1drt CLAVAMINATE SYNTHASE
1

(Streptomyces
clavuligerus) 		PF02668
(TauD) 		4 THR A 172
ARG A  66
ASP A 165
GLU A 265
 AKG  A 326 (-3.0A)
None
None
None
 1.07A 2zw9A-1drtA:
2.8		 2zw9A-1drtA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		4 THR A 299
LEU A 305
GLU A 280
SER A 278
 None
None
MG  A 603 ( 4.2A)
None
 0.79A 2zw9A-1mb9A:
undetectable		 2zw9A-1mb9A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02240
(MCR_gamma) 		4 THR C 140
ARG C 101
ASP C  33
SER C 134
 None
 0.91A 2zw9A-1mroC:
undetectable		 2zw9A-1mroC:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olp ALPHA-TOXIN

(Clostridium
sardiniense) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		4 THR A 103
LYS A 111
ASP A  92
GLU A 354
 None
 0.99A 2zw9A-1olpA:
undetectable		 2zw9A-1olpA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgu ACTIN INTERACTING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 THR A  16
ARG A 358
LEU A  24
SER A 316
 None
 1.04A 2zw9A-1pguA:
11.5		 2zw9A-1pguA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT

(Thauera
aromatica) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		4 THR C  75
ARG C 116
LEU C  24
ASP C  16
 None
 1.03A 2zw9A-1sb3C:
undetectable		 2zw9A-1sb3C:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		4 THR A 501
LYS A 509
ASP A 205
GLU A 275
 None
None
MDO  A 203 ( 4.3A)
None
 0.98A 2zw9A-1w27A:
undetectable		 2zw9A-1w27A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN

(Arabidopsis
thaliana) 		PF00191
(Annexin) 		4 THR A 204
LEU A 193
ASP A 186
GLU A 215
 None
 1.06A 2zw9A-1ycnA:
undetectable		 2zw9A-1ycnA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3z DIALKYLGLYCINE
DECARBOXYLASE

(Burkholderia
cepacia) 		PF00202
(Aminotran_3) 		4 THR A 371
ARG A 174
ASP A 349
GLU A 364
 None
 0.83A 2zw9A-1z3zA:
3.9		 2zw9A-1z3zA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfo GLUTAMYL-TRNA
SYNTHETASE

(Synechococcus
elongatus) 		PF00749
(tRNA-synt_1c) 		4 THR A  54
LEU A  39
ASP A 199
SER A  10
 None
 1.00A 2zw9A-2cfoA:
undetectable		 2zw9A-2cfoA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkd PHOSPHOACETYLGLUCOSA
MINE MUTASE

(Candida
albicans) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		4 THR A 344
ARG A 508
ASP A 266
GLU A 525
 None
 0.97A 2zw9A-2dkdA:
undetectable		 2zw9A-2dkdA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkd PHOSPHOACETYLGLUCOSA
MINE MUTASE

(Candida
albicans) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		4 THR A 344
ARG A 508
ASP A 311
GLU A 525
 None
 1.07A 2zw9A-2dkdA:
undetectable		 2zw9A-2dkdA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9w MAST/STEM CELL
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF00047
(ig) 		4 THR A 276
ASP A 284
GLU A 227
SER A 279
 None
 1.02A 2zw9A-2e9wA:
undetectable		 2zw9A-2e9wA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrv 2A CYSTEINE
PROTEINASE

(Rhinovirus A) 		PF00947
(Pico_P2A) 		4 THR A  55
ASP A 132
LEU A  95
ASP A  76
 None
 1.07A 2zw9A-2hrvA:
undetectable		 2zw9A-2hrvA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHL

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox) 		4 THR C 115
LEU C 122
ASP C 235
SER C 240
 None
 0.97A 2zw9A-2inpC:
undetectable		 2zw9A-2inpC:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF04072
(LCM) 		4 ARG A  81
ASP A 128
ASP A 175
GLU A 201
 None
 0.52A 2zw9A-2ob1A:
31.1		 2zw9A-2ob1A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1

(Sulfolobus
solfataricus) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		4 LYS A  55
LEU A 145
ASP A 149
GLU A 200
 None
 1.09A 2zw9A-2qbyA:
undetectable		 2zw9A-2qbyA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyo HYPOTHETICAL PROTEIN
ML2640

(Mycobacterium
leprae) 		PF04072
(LCM) 		5 THR A  17
ARG A  87
ASP A 132
ASP A 161
GLU A 186
 None
 1.07A 2zw9A-2uyoA:
21.1		 2zw9A-2uyoA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgq SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,MITOCHONDRIA
L
ANTIVIRAL-SIGNALING
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16739
(CARD_2) 		4 THR A  93
LEU A 285
ASP A 287
GLU A 111
 None
None
None
MTT  A1463 (-2.9A)
 1.02A 2zw9A-2vgqA:
undetectable		 2zw9A-2vgqA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		4 THR A  92
LYS A 357
GLU A 129
SER A  84
 None
 0.95A 2zw9A-2vhlA:
undetectable		 2zw9A-2vhlA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl8 CYTOTOXIN L

(Paeniclostridium
sordellii) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		4 ARG A 499
LEU A 511
ASP A 288
GLU A 502
 None
None
CA  A1545 ( 2.8A)
None
 1.08A 2zw9A-2vl8A:
undetectable		 2zw9A-2vl8A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w21 GLUTAMATE 5-KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		4 THR A 216
LEU A 167
ASP A 170
GLU A 135
 None
None
SO4  A1259 (-3.2A)
None
 0.95A 2zw9A-2w21A:
3.0		 2zw9A-2w21A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA

(Escherichia
coli) 		PF02563
(Poly_export)
PF10531
(SLBB) 		4 THR A 330
ARG A  64
LEU A 318
ASP A 322
 None
 0.99A 2zw9A-2w8iA:
undetectable		 2zw9A-2w8iA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Escherichia
coli;
Bovine leukemia
virus) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		4 THR A 119
LEU A 311
ASP A 313
GLU A 137
 None
None
None
MAL  A1488 (-2.9A)
 1.06A 2zw9A-2xz3A:
undetectable		 2zw9A-2xz3A:
21.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		8 THR A  30
LYS A  38
ARG A  88
ASP A 146
LEU A 150
ASP A 196
GLU A 224
SER A 226
 SAH  A 801 (-4.5A)
SAH  A 801 (-2.8A)
SAH  A 801 (-3.9A)
SAH  A 801 (-2.9A)
SAH  A 801 (-4.6A)
SAH  A 801 (-4.1A)
SAH  A 801 (-3.0A)
SAH  A 801 (-4.6A)
 0.23A 2zw9A-2zwaA:
59.3		 2zw9A-2zwaA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1i AMIDASE

(Rhodococcus sp.
N-771) 		PF01425
(Amidase) 		4 THR A 236
ARG A 501
ASP A 271
LEU A 270
 None
 0.96A 2zw9A-3a1iA:
undetectable		 2zw9A-3a1iA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al8 SEMAPHORIN-6A

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		4 THR A 436
ARG A 494
LEU A 312
ASP A 331
 None
 1.03A 2zw9A-3al8A:
5.1		 2zw9A-3al8A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF01048
(PNP_UDP_1) 		4 THR A  85
ASP A  90
ASP A 163
GLU A  98
 None
 0.98A 2zw9A-3bjeA:
3.2		 2zw9A-3bjeA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvw RE11660P

(Drosophila
melanogaster) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 THR A 140
ARG A  17
ASP A 399
LEU A 402
 None
None
None
FAD  A 521 (-4.1A)
 0.85A 2zw9A-3cvwA:
undetectable		 2zw9A-3cvwA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 THR A 145
ARG A 100
ASP A 158
LEU A 159
 GOL  A 804 (-4.8A)
GOL  A 804 ( 4.8A)
None
None
 1.02A 2zw9A-3dlaA:
3.1		 2zw9A-3dlaA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1

(Escherichia
coli;
Arabidopsis
thaliana) 		PF00400
(WD40)
PF01547
(SBP_bac_1) 		4 THR A  93
LEU A 285
ASP A 287
GLU A 111
 None
None
None
GLC  A 672 (-2.8A)
 1.02A 2zw9A-3dm0A:
14.7		 2zw9A-3dm0A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7p PLECTIN-1

(Homo sapiens) 		PF00307
(CH) 		5 ARG A  69
ASP A 269
LEU A 243
ASP A 216
GLU A  66
 None
None
None
EDO  A 294 (-3.6A)
None
 1.48A 2zw9A-3f7pA:
undetectable		 2zw9A-3f7pA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		4 THR A 258
ASP A 552
GLU A 289
SER A 252
 None
 1.06A 2zw9A-3i04A:
2.6		 2zw9A-3i04A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 5

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00346
(Complex1_49kDa)
PF00329
(Complex1_30kDa) 		4 LYS 4 369
LEU 5  49
ASP 5 106
GLU 5 117
 None
 1.10A 2zw9A-3i9v4:
undetectable		 2zw9A-3i9v4:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 THR A 647
ARG A 732
GLU A 588
SER A 725
 None
 1.04A 2zw9A-3iayA:
undetectable		 2zw9A-3iayA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3idv PROTEIN
DISULFIDE-ISOMERASE
A4

(Homo sapiens) 		PF00085
(Thioredoxin) 		4 THR A  81
LEU A 108
ASP A 112
GLU A 166
 None
 1.03A 2zw9A-3idvA:
undetectable		 2zw9A-3idvA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j5y EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1

(Homo sapiens) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 THR A 234
ARG A 198
LEU A 226
SER A 229
 None
 1.02A 2zw9A-3j5yA:
undetectable		 2zw9A-3j5yA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbl NLR FAMILY CARD
DOMAIN-CONTAINING
PROTEIN 4

(Mus musculus) 		no annotation 4 ARG K 745
ASP K 668
GLU K 720
SER K 722
 None
 0.95A 2zw9A-3jblK:
undetectable		 2zw9A-3jblK:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7d GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF03710
(GlnE)
PF08335
(GlnD_UR_UTase) 		4 THR A 524
LEU A 555
GLU A 918
SER A 562
 None
 0.97A 2zw9A-3k7dA:
undetectable		 2zw9A-3k7dA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2j FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PARATHYROID
HORMONE/PARATHYROID
HORMONE-RELATED
PEPTIDE RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		4 THR A-251
LEU A -59
ASP A -57
GLU A-233
 None
None
None
MAL  A 194 (-2.9A)
 1.01A 2zw9A-3l2jA:
undetectable		 2zw9A-3l2jA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mp6 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,LINKER,SAGA-
ASSOCIATED FACTOR 29

(Escherichia
coli;
Saccharomyces
cerevisiae;
unidentified) 		PF07039
(DUF1325)
PF13416
(SBP_bac_8) 		4 THR A 831
LEU A1023
ASP A1025
GLU A 849
 None
None
None
MAL  A 600 (-2.9A)
 1.00A 2zw9A-3mp6A:
undetectable		 2zw9A-3mp6A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzk PROTEIN TRANSPORT
PROTEIN SEC16

(Saccharomyces
cerevisiae) 		PF12931
(Sec16_C)
PF12932
(Sec16) 		4 THR B1268
ASP B1297
ASP B1295
GLU B1301
 None
 0.95A 2zw9A-3mzkB:
undetectable		 2zw9A-3mzkB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		4 THR A-255
LEU A -63
ASP A -61
GLU A-237
 None
None
None
MAL  A5044 (-2.9A)
 1.05A 2zw9A-3n94A:
undetectable		 2zw9A-3n94A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Homo sapiens) 		PF04072
(LCM) 		5 LYS A  37
ARG A  73
ASP A 122
ASP A 171
GLU A 198
 SAM  A 801 (-2.6A)
SAM  A 801 (-3.8A)
SAM  A 801 (-2.7A)
SAM  A 801 (-3.8A)
SAM  A 801 (-3.1A)
 0.36A 2zw9A-3o7wA:
28.0		 2zw9A-3o7wA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0

(Escherichia
coli;
Homo sapiens) 		PF07686
(V-set)
PF13416
(SBP_bac_8) 		4 THR A  93
LEU A 285
ASP A 287
GLU A 111
 None
None
None
MAL  A1122 (-2.9A)
 1.04A 2zw9A-3oaiA:
undetectable		 2zw9A-3oaiA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4

(Saccharomyces
cerevisiae) 		PF11701
(UNC45-central) 		4 THR A 521
ARG A 481
LEU A 502
ASP A 556
 None
 0.90A 2zw9A-3opbA:
undetectable		 2zw9A-3opbA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Escherichia
coli;
Aequorea
victoria) 		PF01353
(GFP)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		4 THR A  93
LEU A 533
ASP A 535
GLU A 111
 None
None
None
MAL  A 700 (-2.9A)
 1.00A 2zw9A-3osqA:
undetectable		 2zw9A-3osqA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		4 THR A 320
LEU A 312
ASP A 315
GLU A 441
 None
 0.90A 2zw9A-3ps5A:
undetectable		 2zw9A-3ps5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpb URIDINE
PHOSPHORYLASE

(Streptococcus
pyogenes) 		PF01048
(PNP_UDP_1) 		4 THR A  70
ASP A 163
GLU A  83
SER A  78
 None
 1.08A 2zw9A-3qpbA:
undetectable		 2zw9A-3qpbA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxf ENDOGLUCANASE

(Escherichia
coli) 		PF01270
(Glyco_hydro_8) 		4 THR A  80
LEU A 144
GLU A  55
SER A  58
 None
 1.05A 2zw9A-3qxfA:
undetectable		 2zw9A-3qxfA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tb2 1-CYS PEROXIREDOXIN

(Plasmodium
yoelii) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 ARG A 152
ASP A  42
ASP A  80
GLU A  50
 None
 0.82A 2zw9A-3tb2A:
undetectable		 2zw9A-3tb2A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tpf ORNITHINE
CARBAMOYLTRANSFERASE

(Campylobacter
jejuni) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LYS A  26
ASP A 131
ASP A 220
GLU A 283
 None
 1.04A 2zw9A-3tpfA:
4.3		 2zw9A-3tpfA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vd8 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
INTERFERON-INDUCIBLE
PROTEIN AIM2

(Escherichia
coli;
Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		4 THR A  93
LEU A 285
ASP A 287
GLU A 111
 None
None
None
MTT  A1205 (-2.9A)
 1.02A 2zw9A-3vd8A:
undetectable		 2zw9A-3vd8A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vw5 CELLOBIOSE
2-EPIMERASE

(Ruminococcus
albus) 		PF07221
(GlcNAc_2-epim) 		4 THR A 248
ARG A 385
LEU A 183
GLU A 381
 None
 0.84A 2zw9A-3vw5A:
undetectable		 2zw9A-3vw5A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyl L-RIBULOSE
3-EPIMERASE

(Mesorhizobium
loti) 		PF01261
(AP_endonuc_2) 		4 THR A  23
LEU A  50
ASP A  44
GLU A  36
 None
 0.97A 2zw9A-3vylA:
undetectable		 2zw9A-3vylA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P
SAR1P

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
PF00025
(Arf) 		4 THR B  54
ASP A 351
LEU B  83
SER A 602
 MG  B1191 ( 3.3A)
None
None
None
 1.06A 2zw9A-4bziB:
undetectable		 2zw9A-4bziB:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 THR A  64
ASP A 549
ASP A 541
GLU A  72
 None
 0.90A 2zw9A-4c30A:
4.9		 2zw9A-4c30A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
26S PROTEASE SUBUNIT
RPT4

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF00004
(AAA) 		4 THR K 279
ARG L 290
LEU K 324
GLU L 293
 None
 1.09A 2zw9A-4cr4K:
undetectable		 2zw9A-4cr4K:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN

(Escherichia
coli;
Mus musculus) 		PF07679
(I-set)
PF13416
(SBP_bac_8) 		4 THR A  94
LEU A 286
ASP A 288
GLU A 112
 None
None
None
MLR  A 500 (-2.2A)
 1.02A 2zw9A-4edqA:
undetectable		 2zw9A-4edqA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA

(Escherichia
coli;
Homo sapiens) 		PF00046
(Homeobox)
PF13416
(SBP_bac_8)
PF16878
(SIX1_SD) 		4 THR A  93
LEU A 285
ASP A 287
GLU A 111
 None
None
None
MAL  A 601 (-2.9A)
 1.02A 2zw9A-4egcA:
undetectable		 2zw9A-4egcA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0w PROTEASE CSPB

(Clostridium
perfringens) 		PF00082
(Peptidase_S8) 		4 LYS B 526
LEU B 430
ASP B 406
GLU B 437
 EDO  B 605 (-2.7A)
None
None
EDO  B 605 (-4.6A)
 0.80A 2zw9A-4i0wB:
2.5		 2zw9A-4i0wB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NACHT, LRR
AND PYD
DOMAINS-CONTAINING
PROTEIN 1

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 THR A  94
LEU A 286
ASP A 288
GLU A 112
 None
None
None
MAL  A 501 (-3.0A)
 1.01A 2zw9A-4ifpA:
undetectable		 2zw9A-4ifpA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irl MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NOVEL PROTEIN
SIMILAR TO
VERTEBRATE GUANYLATE
BINDING PROTEIN
FAMILY

(Escherichia
coli;
Danio rerio) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 THR A  94
LEU A 286
ASP A 288
GLU A 112
 None
None
None
MTT  A 501 (-2.9A)
 1.07A 2zw9A-4irlA:
undetectable		 2zw9A-4irlA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwh TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE

(Schizosaccharomyces
pombe) 		PF01746
(tRNA_m1G_MT) 		4 THR A 120
LEU A  99
ASP A 104
SER A 114
 None
 1.00A 2zw9A-4jwhA:
undetectable		 2zw9A-4jwhA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli;
Mycobacterium
tuberculosis) 		PF08817
(YukD)
PF13416
(SBP_bac_8) 		4 THR A  94
LEU A 286
ASP A 288
GLU A 112
 None
None
None
MAL  A 501 (-3.0A)
 1.04A 2zw9A-4kv3A:
undetectable		 2zw9A-4kv3A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2i NON-LEE ENCODED TYPE
III EFFECTOR C

(Citrobacter
rodentium) 		PF13678
(Peptidase_M85) 		4 LEU A  84
ASP A  92
GLU A  47
SER A  45
 None
 1.10A 2zw9A-4o2iA:
undetectable		 2zw9A-4o2iA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pn0 MRNA-CAPPING ENZYME
SUBUNIT BETA

(Schizosaccharomyces
pombe) 		PF02940
(mRNA_triPase) 		4 THR A  58
ARG A 296
LEU A  65
ASP A 268
 None
 1.05A 2zw9A-4pn0A:
undetectable		 2zw9A-4pn0A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvc NADPH-DEPENDENT
METHYLGLYOXAL
REDUCTASE GRE2

(Saccharomyces
cerevisiae) 		PF01073
(3Beta_HSD) 		4 THR A 331
LEU A 279
ASP A 274
GLU A 218
 None
 1.01A 2zw9A-4pvcA:
5.1		 2zw9A-4pvcA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1z PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF16215
(DUF4876) 		4 THR A 398
ASP A 216
GLU A 223
SER A 220
 None
None
UNX  A 401 ( 3.4A)
None
 0.82A 2zw9A-4q1zA:
undetectable		 2zw9A-4q1zA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA

(Escherichia
coli;
Mus musculus) 		PF13416
(SBP_bac_8)
PF13621
(Cupin_8) 		4 THR A-278
LEU A -86
ASP A -84
GLU A-260
 None
None
None
GLC  A 901 (-3.1A)
 1.06A 2zw9A-4qszA:
undetectable		 2zw9A-4qszA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF04901
(RAMP)
PF13416
(SBP_bac_8) 		4 THR A  95
LEU A 287
ASP A 289
GLU A 113
 None
None
None
MAL  A2201 (-3.0A)
 1.00A 2zw9A-4rwfA:
undetectable		 2zw9A-4rwfA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE

(Leishmania
mexicana) 		PF00155
(Aminotran_1_2) 		4 THR A  92
ARG A 315
ASP A 198
GLU A 319
 None
 1.01A 2zw9A-4wb0A:
3.6		 2zw9A-4wb0A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB

(Escherichia
coli;
Staphylococcus
aureus) 		PF00717
(Peptidase_S24)
PF13416
(SBP_bac_8) 		4 THR A  99
LEU A 291
ASP A 293
GLU A 117
 None
None
None
MAL  A 601 (-2.9A)
 1.08A 2zw9A-4wviA:
undetectable		 2zw9A-4wviA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjx HSDR

(Escherichia
coli) 		PF04313
(HSDR_N)
PF04851
(ResIII)
PF12008
(EcoR124_C) 		4 THR A 661
LEU A 677
GLU A 597
SER A 595
 None
 1.05A 2zw9A-4xjxA:
2.4		 2zw9A-4xjxA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA

(Methanothermobacter
marburgensis) 		PF02240
(MCR_gamma) 		4 THR C 143
ARG C 104
ASP C  36
SER C 137
 None
 0.94A 2zw9A-5a8rC:
undetectable		 2zw9A-5a8rC:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5crv TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 23
SIGNAL TRANSDUCING
ADAPTER MOLECULE 2

(Homo sapiens;
Homo sapiens) 		PF03097
(BRO1)
no annotation 		4 ARG A   6
LEU C 358
GLU A 191
SER A 193
 None
 1.08A 2zw9A-5crvA:
undetectable		 2zw9A-5crvA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwe CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		4 THR A 103
LEU A 149
ASP A 201
GLU A 108
 None
 1.01A 2zw9A-5cweA:
undetectable		 2zw9A-5cweA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl7 PORIN

(Acinetobacter
baumannii) 		PF03573
(OprD) 		4 ARG A 250
ASP A 339
LEU A 341
ASP A 345
 C8E  A 511 (-2.9A)
None
None
None
 0.80A 2zw9A-5dl7A:
undetectable		 2zw9A-5dl7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 THR A 489
ARG A 178
LEU A 521
GLU A 492
 None
 1.08A 2zw9A-5gz4A:
undetectable		 2zw9A-5gz4A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7n NLRP12-PYD WITH MBP
TAG

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		4 THR A  94
LEU A 286
ASP A 288
GLU A 112
 None
None
None
MTT  A 501 (-2.9A)
 1.07A 2zw9A-5h7nA:
undetectable		 2zw9A-5h7nA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm0 ALPHA-MANNOSIDASE,AL
PHA-MANNOSIDASE,ALPH
A-MANNOSIDASE

(Saccharomyces
cerevisiae) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 ARG A 394
ASP A 604
GLU A 995
SER A 610
 None
 1.02A 2zw9A-5jm0A:
undetectable		 2zw9A-5jm0A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 LEU A 429
ASP A 424
GLU A 340
SER A 417
 None
None
BXP  A 509 ( 4.8A)
None
 0.96A 2zw9A-5l6fA:
undetectable		 2zw9A-5l6fA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE ALPHA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 ARG b 641
ASP b 405
LEU b 401
GLU b 447
 None
 0.98A 2zw9A-5l9wb:
undetectable		 2zw9A-5l9wb:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loz EPSIN-1

(Saccharomyces
cerevisiae) 		PF01417
(ENTH) 		4 THR A 130
LEU A  77
ASP A  60
GLU A 107
 None
 1.07A 2zw9A-5lozA:
undetectable		 2zw9A-5lozA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mea CELL DIVISION CYCLE
PROTEIN CDT1

(Saccharomyces
cerevisiae) 		no annotation 4 ARG A 399
LEU A 340
ASP A 358
GLU A 322
 None
 1.00A 2zw9A-5meaA:
undetectable		 2zw9A-5meaA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyp STRUCTURAL PROTEIN
VP2
STRUCTURAL PROTEIN
VP3

(Sacbrood virus;
Sacbrood virus) 		no annotation
no annotation 		4 THR C  66
ARG C  89
LEU B 203
ASP B  77
 None
 1.07A 2zw9A-5oypC:
undetectable		 2zw9A-5oypC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF04598
(Gasdermin)
PF13416
(SBP_bac_8) 		4 THR A  93
LEU A 285
ASP A 287
GLU A 111
 None
None
None
MAL  A1501 (-3.0A)
 1.01A 2zw9A-5tj2A:
undetectable		 2zw9A-5tj2A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN

(Escherichia
coli;
Streptococcus
pyogenes) 		PF12892
(FctA)
PF13416
(SBP_bac_8) 		4 THR A  99
LEU A 291
ASP A 293
GLU A 117
 None
None
None
MLR  A 501 (-2.8A)
 0.98A 2zw9A-5ttdA:
undetectable		 2zw9A-5ttdA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE

(Homo sapiens) 		PF04095
(NAPRTase) 		4 THR A 218
ARG A 477
LEU A 386
SER A 209
 None
 0.87A 2zw9A-5u2nA:
undetectable		 2zw9A-5u2nA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR

(Escherichia
coli;
Homo sapiens) 		no annotation 4 THR A  95
LEU A 287
ASP A 289
GLU A 113
 None
None
None
MAL  A2201 (-3.2A)
 1.00A 2zw9A-5v6yA:
undetectable		 2zw9A-5v6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq6 MBP TAGGED HMNDA-PYD

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		4 THR A  94
LEU A 286
ASP A 288
GLU A 112
 None
None
None
MAL  A 501 (-2.9A)
 1.08A 2zw9A-5wq6A:
undetectable		 2zw9A-5wq6A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus) 		no annotation 4 THR A 359
LEU A 389
GLU A 327
SER A 354
 None
 0.92A 2zw9A-5ybbA:
undetectable		 2zw9A-5ybbA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage JBD30) 		no annotation 4 THR A 173
LEU A 365
ASP A 367
GLU A 191
 None
None
None
MTT  A 501 (-2.7A)
 1.04A 2zw9A-6anvA:
undetectable		 2zw9A-6anvA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b12 TNE2

(Pseudomonas
protegens) 		no annotation 4 THR A 375
LEU A 378
ASP A 350
GLU A 389
 None
 0.80A 2zw9A-6b12A:
undetectable		 2zw9A-6b12A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE

(Escherichia
coli) 		no annotation 4 LEU A 126
ASP A 121
GLU A 341
SER A 340
 None
 1.07A 2zw9A-6bqcA:
4.2		 2zw9A-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dm8 -

(-) 		no annotation 4 THR A-122
LEU A  70
ASP A  72
GLU A-104
 None
None
None
MAL  A 402 (-3.0A)
 1.04A 2zw9A-6dm8A:
undetectable		 2zw9A-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eh1 STRUCTURAL PROTEIN
VP2
STRUCTURAL PROTEIN
VP3

(Sacbrood virus;
Sacbrood virus) 		no annotation
no annotation 		4 THR C  66
ARG C  89
LEU B 203
ASP B  77
 None
 1.06A 2zw9A-6eh1C:
undetectable		 2zw9A-6eh1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejf


(;
) 		no annotation
no annotation 		4 LYS J 175
LEU G 431
ASP G 401
GLU J 217
 None
 1.10A 2zw9A-6ejfJ:
undetectable		 2zw9A-6ejfJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn0 -

(-) 		no annotation 4 THR A 135
ARG A  16
ASP A 391
LEU A 394
 None
None
None
FAD  A 501 (-3.8A)
 0.85A 2zw9A-6fn0A:
undetectable		 2zw9A-6fn0A:
undetectable