SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZW9_A_SAMA801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 ILE A 454
ASN A 451
GLY A 436
GLY A 438
TYR A 427
 None
 1.12A 2zw9A-1aorA:
undetectable		 2zw9A-1aorA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cle CHOLESTEROL ESTERASE

([Candida]
cylindracea) 		PF00135
(COesterase) 		5 ILE A 169
GLY A 255
GLY A 252
ASP A 248
TYR A 259
 None
 1.24A 2zw9A-1cleA:
2.6		 2zw9A-1cleA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT

(Methanopyrus
kandleri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 ASN A 279
GLY A 283
GLY A 267
TYR A 326
MET A 327
 None
 1.21A 2zw9A-1e6vA:
undetectable		 2zw9A-1e6vA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanosarcina
barkeri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 ASN A1290
GLY A1294
GLY A1278
TYR A1336
MET A1337
 None
None
None
None
AGM  A1285 (-3.9A)
 1.23A 2zw9A-1e6yA:
undetectable		 2zw9A-1e6yA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1euf DUODENASE

(Bos taurus) 		PF00089
(Trypsin) 		5 ILE A 121
GLY A  44
GLY A 197
ASP A 194
TYR A  29
 None
 1.25A 2zw9A-1eufA:
undetectable		 2zw9A-1eufA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		5 ILE A 169
GLY A 255
GLY A 252
ASP A 248
TYR A 259
 None
 1.19A 2zw9A-1gz7A:
3.1		 2zw9A-1gz7A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4w TRYPSIN IVA

(Homo sapiens) 		PF00089
(Trypsin) 		5 ILE A 121
GLY A  44
GLY A 197
ASP A 194
TYR A  29
 None
 1.26A 2zw9A-1h4wA:
undetectable		 2zw9A-1h4wA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdi PHOSPHOGLYCERATE
KINASE

(Sus scrofa) 		PF00162
(PGK) 		5 ILE A 223
ASN A 336
GLY A 212
GLY A 337
ASP A 374
 None
None
None
None
MG  A 418 ( 3.0A)
 1.25A 2zw9A-1hdiA:
undetectable		 2zw9A-1hdiA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyl HYPODERMA LINEATUM
COLLAGENASE

(Hypoderma
lineatum) 		PF00089
(Trypsin) 		5 ILE A 121
GLY A  44
GLY A 197
ASP A 194
TYR A  29
 None
 1.20A 2zw9A-1hylA:
undetectable		 2zw9A-1hylA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		5 ILE A 227
ASN A  89
GLY A 232
LEU A 266
TYR A 239
 None
 1.18A 2zw9A-1iv8A:
2.1		 2zw9A-1iv8A:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzk HEROIN ESTERASE

(Rhodococcus sp.) 		PF07859
(Abhydrolase_3) 		5 GLN A 184
GLY A 158
GLY A 163
LEU A  82
TYR A 253
 None
 1.25A 2zw9A-1lzkA:
3.6		 2zw9A-1lzkA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqs SLY1 PROTEIN

(Saccharomyces
cerevisiae) 		PF00995
(Sec1) 		5 ILE A 210
ASN A 205
GLY A 202
ASP A 201
LEU A 261
 None
 1.23A 2zw9A-1mqsA:
undetectable		 2zw9A-1mqsA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus) 		PF01425
(Amidase) 		5 SER A 246
GLY A 281
GLY A 235
ASP A 237
LEU A 297
 None
None
None
MAY  A 600 (-4.4A)
None
 1.21A 2zw9A-1mt5A:
undetectable		 2zw9A-1mt5A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvk ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 220
GLY A 222
LEU A 246
TYR A 211
MET A 235
 None
 1.16A 2zw9A-1rvkA:
undetectable		 2zw9A-1rvkA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ARP2/3 COMPLEX 16KDA
SUBUNIT

(Bos taurus) 		PF04699
(P16-Arc) 		5 ILE G 110
SER G 116
GLY G  76
ASP G  73
LEU G 105
 None
 1.25A 2zw9A-1u2vG:
undetectable		 2zw9A-1u2vG:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpv UPF0230 PROTEIN
TM1468

(Thermotoga
maritima) 		PF02645
(DegV) 		5 ILE A 281
GLY A 234
GLY A 123
ASP A  12
LEU A 247
 None
None
PLM  A 501 (-4.0A)
None
None
 1.22A 2zw9A-1vpvA:
2.1		 2zw9A-1vpvA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrz XYLAN
BETA-1,4-XYLOSIDASE

(Bacillus
halodurans) 		PF04616
(Glyco_hydro_43) 		5 ILE A1284
GLN A1285
GLY A1251
GLY A1249
LEU A1253
 None
 1.19A 2zw9A-1yrzA:
6.6		 2zw9A-1yrzA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE

(Chromobacterium
violaceum) 		PF01869
(BcrAD_BadFG) 		5 ILE A  79
SER A  52
GLY A  82
GLY A  18
LEU A 290
 None
 0.96A 2zw9A-1zc6A:
undetectable		 2zw9A-1zc6A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esb DUAL SPECIFICITY
PROTEIN PHOSPHATASE
18

(Homo sapiens) 		PF00782
(DSPc) 		5 ILE A 174
ASN A 144
SER A 109
GLY A 146
TYR A 178
 None
None
EPE  A1002 (-4.3A)
None
None
 1.17A 2zw9A-2esbA:
undetectable		 2zw9A-2esbA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2evv HYPOTHETICAL PROTEIN
HP0218

(Helicobacter
pylori) 		PF01161
(PBP) 		5 ILE A 125
GLY A  22
LEU A  29
ASN A  30
TYR A 124
 None
 1.25A 2zw9A-2evvA:
undetectable		 2zw9A-2evvA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		5 GLN A 286
SER A 374
ASP A 291
TYR A 329
LEU A 266
 None
 1.25A 2zw9A-2fuqA:
undetectable		 2zw9A-2fuqA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fx5 LIPASE

(Pseudomonas
mendocina) 		no annotation 5 GLN A 127
ASN A  56
GLY A 124
GLY A  55
ASN A 184
 None
 1.18A 2zw9A-2fx5A:
2.0		 2zw9A-2fx5A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf0 BILE SALT HYDROLASE

(Bifidobacterium
longum) 		PF02275
(CBAH) 		5 ILE A  54
ASN A  71
GLY A  74
ASP A 146
TYR A 286
 None
 1.17A 2zw9A-2hf0A:
undetectable		 2zw9A-2hf0A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjh NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		5 ILE A 516
SER A 323
GLY A 471
GLY A 264
LEU A 494
 None
None
XYQ  A1222 (-3.6A)
XYQ  A1222 (-3.4A)
None
 0.97A 2zw9A-2hjhA:
undetectable		 2zw9A-2hjhA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfq GLUTAMATE RACEMASE

(Staphylococcus
aureus) 		PF01177
(Asp_Glu_race) 		5 ILE A 181
SER A 177
GLY A 140
TYR A 125
ASN A  73
 None
None
None
None
DGL  A1267 (-4.3A)
 1.14A 2zw9A-2jfqA:
undetectable		 2zw9A-2jfqA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF04072
(LCM) 		7 GLY A 105
GLY A 107
ASP A 109
LEU A 176
ASN A 177
TYR A 206
MET A 207
 None
None
PO4  A2001 (-3.1A)
None
None
None
None
 0.68A 2zw9A-2ob1A:
31.1		 2zw9A-2ob1A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paa PHOSPHOGLYCERATE
KINASE, TESTIS
SPECIFIC

(Mus musculus) 		PF00162
(PGK) 		5 ILE A 223
ASN A 336
GLY A 213
GLY A 337
ASP A 374
 None
ATP  A 500 (-3.6A)
ATP  A 500 (-2.8A)
ATP  A 500 (-3.1A)
ATP  A 500 (-4.1A)
 1.13A 2zw9A-2paaA:
undetectable		 2zw9A-2paaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfy PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03480
(DctP) 		5 ILE A  62
GLN A  61
ASN A 214
GLY A  54
LEU A  46
 None
 1.26A 2zw9A-2pfyA:
undetectable		 2zw9A-2pfyA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qor GUANYLATE KINASE

(Plasmodium
vivax) 		PF00625
(Guanylate_kin) 		5 ILE A 131
ASN A 172
GLY A  14
GLY A  16
LEU A 136
 None
None
POP  A 198 (-3.3A)
POP  A 198 (-3.3A)
None
 1.16A 2zw9A-2qorA:
undetectable		 2zw9A-2qorA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdw PUTATIVE HEXOSE
OXIDASE

(Nonomuraea
gerenzanensis) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 ASN A 472
GLY A 216
GLY A 162
LEU A 502
TYR A 494
 FAD  A 601 (-3.7A)
None
None
None
None
 1.15A 2zw9A-2wdwA:
undetectable		 2zw9A-2wdwA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdw PUTATIVE HEXOSE
OXIDASE

(Nonomuraea
gerenzanensis) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 ASN A 472
GLY A 217
GLY A 162
LEU A 502
TYR A 494
 FAD  A 601 (-3.7A)
None
None
None
None
 1.24A 2zw9A-2wdwA:
undetectable		 2zw9A-2wdwA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3s TAML

(Streptomyces
sp. 307-9) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 ASN A 446
GLY A 187
GLY A 133
LEU A 476
TYR A 468
 FAD  A 600 (-3.5A)
None
None
None
None
 1.22A 2zw9A-2y3sA:
undetectable		 2zw9A-2y3sA:
20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		12 ILE A  27
GLN A  28
ASN A  31
SER A  34
GLY A 115
GLY A 117
ASP A 119
TYR A 147
LEU A 197
ASN A 198
TYR A 229
MET A 230
 SAH  A 801 (-4.4A)
None
SAH  A 801 (-4.6A)
SAH  A 801 (-3.6A)
SAH  A 801 (-3.5A)
SAH  A 801 (-3.4A)
SAH  A 801 ( 4.3A)
SAH  A 801 (-3.8A)
SAH  A 801 (-3.7A)
SAH  A 801 (-3.9A)
None
SAH  A 801 ( 3.8A)
 0.28A 2zw9A-2zwaA:
59.3		 2zw9A-2zwaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		5 ILE A  27
GLN A  28
GLY A 117
TYR A 147
TYR A 229
 SAH  A 801 (-4.4A)
None
SAH  A 801 (-3.4A)
SAH  A 801 (-3.8A)
None
 1.16A 2zw9A-2zwaA:
59.3		 2zw9A-2zwaA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 ASN A1330
GLY A1435
ASP A1432
LEU A1392
TYR A1369
 None
 0.77A 2zw9A-2zxqA:
undetectable		 2zw9A-2zxqA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aat ASPARTATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 ILE A 330
GLN A 331
ASN A 357
GLY A 227
LEU A 323
 None
 1.07A 2zw9A-3aatA:
3.3		 2zw9A-3aatA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b40 PROBABLE DIPEPTIDASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		5 ILE A 261
SER A 266
GLY A 193
LEU A 233
ASN A 234
 None
 1.17A 2zw9A-3b40A:
undetectable		 2zw9A-3b40A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ct9 ACETYLORNITHINE
DEACETYLASE

(Bacteroides
thetaiotaomicron) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ASN A 103
SER A 327
GLY A 320
GLY A 322
LEU A 112
 None
 1.16A 2zw9A-3ct9A:
undetectable		 2zw9A-3ct9A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Rhodospirillum
rubrum) 		PF00440
(TetR_N) 		5 ASN A 130
GLY A  65
ASP A  62
LEU A  29
MET A 112
 None
 1.10A 2zw9A-3cwrA:
undetectable		 2zw9A-3cwrA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4u CARBOXYPEPTIDASE B2

(Bos taurus) 		PF00246
(Peptidase_M14) 		5 ILE A 164
ASN A 144
GLY A 253
ASP A 255
LEU A 249
 None
ACT  A 601 (-3.8A)
None
None
None
 1.25A 2zw9A-3d4uA:
undetectable		 2zw9A-3d4uA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfr DIHYDROFOLATE
REDUCTASE

(Lactobacillus
casei) 		PF00186
(DHFR_1) 		5 GLN A 101
SER A  48
GLY A  98
GLY A  42
MET A 128
 NDP  A 163 ( 3.6A)
MTX  A 164 (-3.5A)
NDP  A 163 (-3.8A)
NDP  A 163 ( 3.6A)
None
 1.24A 2zw9A-3dfrA:
undetectable		 2zw9A-3dfrA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxk GOOSE-TYPE LYSOZYME
1

(Gadus morhua) 		PF01464
(SLT) 		5 ILE A 131
GLN A 132
GLY A   6
ASP A   7
LEU A 124
 None
 1.11A 2zw9A-3gxkA:
undetectable		 2zw9A-3gxkA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3l PUTATIVE SUGAR
HYDROLASE

(Parabacteroides
distasonis) 		PF06439
(DUF1080) 		5 GLN A 144
ASN A 161
GLY A 160
ASP A 159
MET A 200
 None
 1.19A 2zw9A-3h3lA:
undetectable		 2zw9A-3h3lA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7k AGMATINE DEIMINASE

(Arabidopsis
thaliana) 		PF04371
(PAD_porph) 		5 ASN A 123
GLY A 131
GLY A 127
TYR A 133
ASN A  35
 None
NA  A 385 ( 4.5A)
None
None
AGT  A 366 ( 4.8A)
 1.23A 2zw9A-3h7kA:
undetectable		 2zw9A-3h7kA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Haemophilus
influenzae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ASN A  50
GLY A 141
ASP A 140
LEU A 333
MET A 150
 None
 1.09A 2zw9A-3ic1A:
undetectable		 2zw9A-3ic1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN

(Bacteroides
thetaiotaomicron) 		PF01823
(MACPF) 		5 GLY A 232
GLY A 358
ASP A 357
LEU A  73
TYR A  77
 None
 0.97A 2zw9A-3kk7A:
undetectable		 2zw9A-3kk7A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Sulfolobus
solfataricus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 ILE A 196
GLY A 233
ASP A 120
LEU A 154
ASN A 152
 None
 1.23A 2zw9A-3l7zA:
undetectable		 2zw9A-3l7zA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		5 ILE A 206
SER A 257
GLY A 200
ASP A 234
ASN A 272
 None
 1.24A 2zw9A-3ll8A:
undetectable		 2zw9A-3ll8A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN

(Sinorhizobium
meliloti) 		PF01557
(FAA_hydrolase) 		5 GLN A  80
SER A 194
GLY A 261
LEU A 244
TYR A 113
 None
 1.19A 2zw9A-3lzkA:
undetectable		 2zw9A-3lzkA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Homo sapiens) 		PF04072
(LCM) 		6 GLY A  98
GLY A 100
ASP A 102
LEU A 172
TYR A 203
MET A 204
 SAM  A 801 (-3.5A)
SAM  A 801 ( 3.7A)
None
SAM  A 801 (-3.7A)
SAM  A 801 (-4.6A)
None
 0.75A 2zw9A-3o7wA:
28.0		 2zw9A-3o7wA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Homo sapiens) 		PF04072
(LCM) 		5 SER A  34
GLY A  98
GLY A 100
ASP A 102
LEU A 172
 None
SAM  A 801 (-3.5A)
SAM  A 801 ( 3.7A)
None
SAM  A 801 (-3.7A)
 1.16A 2zw9A-3o7wA:
28.0		 2zw9A-3o7wA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osl CARBOXYPEPTIDASE B2

(Bos taurus) 		PF00246
(Peptidase_M14) 		5 ILE A 277
ASN A 256
GLY A 368
ASP A 370
LEU A 364
 None
 1.25A 2zw9A-3oslA:
undetectable		 2zw9A-3oslA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgv HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Klebsiella
pneumoniae) 		PF08282
(Hydrolase_3) 		5 ILE A 248
ASN A 251
GLY A  11
ASP A  10
LEU A 222
 None
None
GOL  A 272 ( 4.2A)
EPE  A 268 (-3.2A)
None
 1.05A 2zw9A-3pgvA:
undetectable		 2zw9A-3pgvA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgv HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Klebsiella
pneumoniae) 		PF08282
(Hydrolase_3) 		5 ILE A 248
ASN A 251
GLY A 213
GLY A  11
LEU A 222
 None
None
None
GOL  A 272 ( 4.2A)
None
 1.19A 2zw9A-3pgvA:
undetectable		 2zw9A-3pgvA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm9 PUTATIVE
OXIDOREDUCTASE

(Rhodopseudomonas
palustris) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		5 ILE A 468
ASN A 470
GLY A 214
GLY A 211
LEU A 181
 None
FAD  A 476 (-4.0A)
None
FAD  A 476 (-3.2A)
None
 0.98A 2zw9A-3pm9A:
undetectable		 2zw9A-3pm9A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnb OXACILLINASE

(Escherichia
coli) 		PF00905
(Transpeptidase) 		5 ILE A  76
ASN A 184
SER A 181
GLY A  81
TYR A 135
 None
None
SO4  A   6 (-4.8A)
None
None
 1.19A 2zw9A-3qnbA:
undetectable		 2zw9A-3qnbA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 ILE A  61
ASN A 104
GLY A 102
ASP A 108
TYR A  78
 None
 1.13A 2zw9A-3s5kA:
undetectable		 2zw9A-3s5kA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF13419
(HAD_2) 		5 ILE A 191
GLN A 124
ASN A 125
GLY A 116
LEU A 194
 None
None
None
CA  A   4 ( 4.5A)
None
 1.13A 2zw9A-3s6jA:
2.2		 2zw9A-3s6jA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sjn MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 299
GLN A 272
SER A 312
GLY A 302
ASN A 222
 None
None
None
None
UNL  A 375 ( 2.9A)
 1.07A 2zw9A-3sjnA:
2.1		 2zw9A-3sjnA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snx PUTATIVE SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 GLN A  75
GLY A 416
GLY A 418
ASP A 421
ASN A 290
 None
EDO  A 499 (-4.2A)
None
None
None
 1.14A 2zw9A-3snxA:
undetectable		 2zw9A-3snxA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyh LYSOZYME G

(Struthio
camelus) 		PF01464
(SLT) 		5 ILE A 127
GLN A 128
GLY A   6
ASP A   7
LEU A 120
 None
 1.04A 2zw9A-3wyhA:
undetectable		 2zw9A-3wyhA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq4 RIBONUCLEASE J 1

(Bacillus
subtilis) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		5 ILE A 435
ASN A 418
GLY A  15
LEU A  60
ASN A  63
 None
 1.02A 2zw9A-3zq4A:
undetectable		 2zw9A-3zq4A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 ILE A  42
GLY A  93
GLY A 249
ASP A 250
MET A 114
 None
None
None
ZN  A1595 ( 3.2A)
None
 1.17A 2zw9A-3zu0A:
undetectable		 2zw9A-3zu0A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8s ADP-DEPENDENT
GLUCOKINASE

(Thermococcus
litoralis) 		PF04587
(ADP_PFK_GK) 		5 GLN A 121
SER A 456
GLY A 448
GLY A 450
ASN A  40
 GLC  A 468 ( 4.8A)
None
GLC  A 468 ( 4.0A)
AMP  A1472 ( 3.7A)
GLC  A 468 ( 4.1A)
 1.24A 2zw9A-4b8sA:
2.1		 2zw9A-4b8sA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8d GLYCOSYL HYDROLASE,
FAMILY 35

(Streptococcus
pneumoniae) 		PF01301
(Glyco_hydro_35) 		5 ILE A  95
ASN A 454
GLY A 288
LEU A  57
TYR A  52
 None
 1.23A 2zw9A-4e8dA:
undetectable		 2zw9A-4e8dA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		5 ILE A 516
SER A 323
GLY A 471
GLY A 264
LEU A 494
 None
None
APR  A 602 (-3.7A)
APR  A 602 (-3.3A)
None
 0.95A 2zw9A-4iaoA:
2.0		 2zw9A-4iaoA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		5 ILE A 485
SER A 324
GLY A 440
GLY A 263
LEU A 463
 None
 0.92A 2zw9A-4ig9A:
undetectable		 2zw9A-4ig9A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcm CYCLODEXTRIN
GLUCANOTRANSFERASE

([Bacillus]
clarkii) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 GLN A 430
ASN A 429
GLY A 475
ASP A 328
LEU A 472
 None
 1.18A 2zw9A-4jcmA:
undetectable		 2zw9A-4jcmA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE

(Drosophila
melanogaster) 		PF01144
(CoA_trans) 		5 ASN A 113
GLY A  92
GLY A  94
ASP A  90
ASN A 223
 None
 1.14A 2zw9A-4kgbA:
undetectable		 2zw9A-4kgbA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh3 ANTIGEN 43

(Escherichia
coli) 		PF16168
(AIDA) 		5 GLN A 225
GLY A 223
ASP A 222
ASN A 247
TYR A 207
 None
None
None
MLI  A 605 (-2.6A)
None
 1.12A 2zw9A-4kh3A:
undetectable		 2zw9A-4kh3A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK

(Escherichia
coli) 		PF02733
(Dak1) 		5 ILE A 217
SER A 141
GLY A 214
GLY A 222
ASN A 283
 None
 1.19A 2zw9A-4lryA:
undetectable		 2zw9A-4lryA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo2 UDP-GALACTOPYRANOSE
MUTASE

(Campylobacter
jejuni) 		no annotation 5 ILE B 226
GLY B 230
GLY B 341
TYR B 235
LEU B 213
 None
FDA  B 402 (-3.5A)
None
None
FDA  B 402 ( 4.1A)
 1.20A 2zw9A-4mo2B:
undetectable		 2zw9A-4mo2B:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF01425
(Amidase) 		5 SER A 154
GLY A 101
ASP A  98
ASN A 341
TYR A 285
 GLN  A 501 (-1.2A)
None
None
None
GLN  A 501 (-4.3A)
 1.18A 2zw9A-4n0iA:
undetectable		 2zw9A-4n0iA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 ILE A 857
GLN A 856
ASN A 790
SER A 795
GLY A 853
 None
 1.14A 2zw9A-4nenA:
13.3		 2zw9A-4nenA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odd LIPOCALIN ALLERGEN

(Canis lupus) 		no annotation 5 ILE B  36
SER B  22
GLY B  32
GLY B  29
ASP B  26
 None
 1.15A 2zw9A-4oddB:
undetectable		 2zw9A-4oddB:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojz PUTATIVE ALGINATE
LYASE

(Saccharophagus
degradans) 		PF05426
(Alginate_lyase)
PF07940
(Hepar_II_III) 		5 ILE A 199
GLN A 241
ASN A 197
GLY A 234
GLY A 229
 None
 1.15A 2zw9A-4ojzA:
undetectable		 2zw9A-4ojzA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		5 ILE A 119
ASN A 113
GLY A  70
ASP A  69
TYR A  58
 None
 1.20A 2zw9A-4u1rA:
2.4		 2zw9A-4u1rA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 ASN A 478
GLY A 236
GLY A 190
LEU A 508
TYR A 500
 FAD  A 601 (-3.7A)
None
None
None
None
 1.21A 2zw9A-4ud8A:
undetectable		 2zw9A-4ud8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uob ENDONUCLEASE III-3

(Deinococcus
radiodurans) 		PF00730
(HhH-GPD) 		5 ASN A 251
GLY A 293
GLY A 297
ASP A 299
LEU A 289
 None
 1.24A 2zw9A-4uobA:
undetectable		 2zw9A-4uobA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ILE A 270
GLN A 269
GLY A 226
GLY A 224
LEU A 229
 None
 1.16A 2zw9A-4w7sA:
3.8		 2zw9A-4w7sA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmo XEEL PROTEIN

(Xenopus laevis) 		no annotation 5 ASN F 139
GLY F 298
GLY F 142
ASP F 143
TYR F 223
 None
 1.07A 2zw9A-4wmoF:
undetectable		 2zw9A-4wmoF:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ILE A 322
ASN A  74
SER A  81
GLY A 359
LEU A 131
 None
 1.13A 2zw9A-4yzoA:
undetectable		 2zw9A-4yzoA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		5 ILE A 335
SER A 407
GLY A 332
GLY A 330
LEU A 259
 None
None
A  C  76 ( 4.7A)
A  C  76 ( 4.6A)
None
 1.27A 2zw9A-5ah5A:
undetectable		 2zw9A-5ah5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzt CYLM

(Enterococcus
faecalis) 		PF05147
(LANC_like)
PF13575
(DUF4135) 		5 GLY A 965
GLY A 972
LEU A 690
ASN A 691
TYR A 695
 None
 1.10A 2zw9A-5dztA:
2.2		 2zw9A-5dztA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B

(Neotoma lepida) 		PF00067
(p450) 		5 ILE A 178
ASN A 444
GLY A 438
GLY A 440
LEU A 295
 None
None
HEM  A 501 (-3.8A)
None
None
 1.19A 2zw9A-5e0eA:
undetectable		 2zw9A-5e0eA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eny POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ILE A   7
SER A 172
GLY A 237
LEU A 359
ASN A 362
 None
 1.18A 2zw9A-5enyA:
undetectable		 2zw9A-5enyA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epv BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE

(Brucella
abortus) 		PF07536
(HWE_HK) 		5 ILE A 402
SER A 396
GLY A 462
GLY A 426
LEU A 464
 None
 1.06A 2zw9A-5epvA:
undetectable		 2zw9A-5epvA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9s SERINE--PYRUVATE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		5 ILE A 220
SER A 207
GLY A  82
LEU A 242
ASN A  92
 None
None
PLP  A 401 (-3.6A)
None
None
 1.26A 2zw9A-5f9sA:
undetectable		 2zw9A-5f9sA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmx CARBOXYLESTERASE

(uncultured
bacterium) 		PF00144
(Beta-lactamase) 		5 GLY A 372
GLY A 346
ASP A 367
LEU A 331
ASN A 327
 None
 1.25A 2zw9A-5gmxA:
undetectable		 2zw9A-5gmxA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmx CARBOXYLESTERASE

(uncultured
bacterium) 		PF00144
(Beta-lactamase) 		5 ILE A 380
GLY A 372
ASP A 367
LEU A 331
ASN A 327
 None
 1.01A 2zw9A-5gmxA:
undetectable		 2zw9A-5gmxA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1k GEM-ASSOCIATED
PROTEIN 5

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		5 GLY A 445
GLY A 449
ASP A 448
LEU A 476
TYR A 474
 None
 1.25A 2zw9A-5h1kA:
8.8		 2zw9A-5h1kA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd4 LAE6

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 GLN A 185
GLY A 159
GLY A 164
LEU A  83
MET A 309
 None
 1.27A 2zw9A-5jd4A:
3.2		 2zw9A-5jd4A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k2l CHITINASE, LYSOZYME

(Volvox carteri) 		PF01476
(LysM) 		5 ILE A  16
GLY A  21
LEU A  30
ASN A  31
TYR A   5
 None
 1.23A 2zw9A-5k2lA:
undetectable		 2zw9A-5k2lA:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqr POLYCOMB PROTEIN EED

(Chaetomium
thermophilum) 		PF00400
(WD40) 		5 ILE A 230
ASN A 212
SER A 204
GLY A 183
GLY A 185
 None
 1.14A 2zw9A-5tqrA:
12.8		 2zw9A-5tqrA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhu MYCINAMICIN IV
HYDROXYLASE/EPOXIDAS
E

(Micromonospora
griseorubida) 		PF00067
(p450) 		5 ASN A 315
GLY A 340
GLY A 338
LEU A  56
TYR A  49
 None
 1.26A 2zw9A-5uhuA:
undetectable		 2zw9A-5uhuA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y28 -

(-) 		no annotation 5 ILE A 128
ASN A  57
SER A 101
GLY A 185
GLY A 183
 None
 1.25A 2zw9A-5y28A:
undetectable		 2zw9A-5y28A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yjp HUMAN CHYMASE

(Homo sapiens) 		no annotation 5 ILE A  73
SER A  22
GLY A 142
GLY A 140
TYR A  32
 None
 1.27A 2zw9A-5yjpA:
undetectable		 2zw9A-5yjpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E

(Mus musculus) 		no annotation 5 ILE A 779
GLN A 778
GLY A 772
ASP A 770
LEU A 757
 None
 1.26A 2zw9A-5yudA:
undetectable		 2zw9A-5yudA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 5 GLN A 534
GLY A 536
GLY A 437
LEU A 558
TYR A 529
 None
 1.11A 2zw9A-5zl9A:
undetectable		 2zw9A-5zl9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byx SHORT ULVAN LYASE

(Alteromonas sp.
LOR) 		no annotation 5 ILE A  84
GLY A  88
ASP A  89
LEU A 511
TYR A 103
 None
 1.18A 2zw9A-6byxA:
3.2		 2zw9A-6byxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7g TYROSINE
PHENOL-LYASE

(Pantoea
agglomerans) 		PF01212
(Beta_elim_lyase) 		4 THR A 402
LEU A 405
ASP A  50
GLU A 338
 None
 1.07A 2zw9A-1c7gA:
2.8		 2zw9A-1c7gA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1drt CLAVAMINATE SYNTHASE
1

(Streptomyces
clavuligerus) 		PF02668
(TauD) 		4 THR A 172
ARG A  66
ASP A 165
GLU A 265
 AKG  A 326 (-3.0A)
None
None
None
 1.07A 2zw9A-1drtA:
2.8		 2zw9A-1drtA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		4 THR A 299
LEU A 305
GLU A 280
SER A 278
 None
None
MG  A 603 ( 4.2A)
None
 0.79A 2zw9A-1mb9A:
undetectable		 2zw9A-1mb9A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02240
(MCR_gamma) 		4 THR C 140
ARG C 101
ASP C  33
SER C 134
 None
 0.91A 2zw9A-1mroC:
undetectable		 2zw9A-1mroC:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olp ALPHA-TOXIN

(Clostridium
sardiniense) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		4 THR A 103
LYS A 111
ASP A  92
GLU A 354
 None
 0.99A 2zw9A-1olpA:
undetectable		 2zw9A-1olpA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgu ACTIN INTERACTING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 THR A  16
ARG A 358
LEU A  24
SER A 316
 None
 1.04A 2zw9A-1pguA:
11.5		 2zw9A-1pguA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT

(Thauera
aromatica) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		4 THR C  75
ARG C 116
LEU C  24
ASP C  16
 None
 1.03A 2zw9A-1sb3C:
undetectable		 2zw9A-1sb3C:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		4 THR A 501
LYS A 509
ASP A 205
GLU A 275
 None
None
MDO  A 203 ( 4.3A)
None
 0.98A 2zw9A-1w27A:
undetectable		 2zw9A-1w27A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN

(Arabidopsis
thaliana) 		PF00191
(Annexin) 		4 THR A 204
LEU A 193
ASP A 186
GLU A 215
 None
 1.06A 2zw9A-1ycnA:
undetectable		 2zw9A-1ycnA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3z DIALKYLGLYCINE
DECARBOXYLASE

(Burkholderia
cepacia) 		PF00202
(Aminotran_3) 		4 THR A 371
ARG A 174
ASP A 349
GLU A 364
 None
 0.83A 2zw9A-1z3zA:
3.9		 2zw9A-1z3zA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfo GLUTAMYL-TRNA
SYNTHETASE

(Synechococcus
elongatus) 		PF00749
(tRNA-synt_1c) 		4 THR A  54
LEU A  39
ASP A 199
SER A  10
 None
 1.00A 2zw9A-2cfoA:
undetectable		 2zw9A-2cfoA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkd PHOSPHOACETYLGLUCOSA
MINE MUTASE

(Candida
albicans) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		4 THR A 344
ARG A 508
ASP A 266
GLU A 525
 None
 0.97A 2zw9A-2dkdA:
undetectable		 2zw9A-2dkdA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkd PHOSPHOACETYLGLUCOSA
MINE MUTASE

(Candida
albicans) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		4 THR A 344
ARG A 508
ASP A 311
GLU A 525
 None
 1.07A 2zw9A-2dkdA:
undetectable		 2zw9A-2dkdA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9w MAST/STEM CELL
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF00047
(ig) 		4 THR A 276
ASP A 284
GLU A 227
SER A 279
 None
 1.02A 2zw9A-2e9wA:
undetectable		 2zw9A-2e9wA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrv 2A CYSTEINE
PROTEINASE

(Rhinovirus A) 		PF00947
(Pico_P2A) 		4 THR A  55
ASP A 132
LEU A  95
ASP A  76
 None
 1.07A 2zw9A-2hrvA:
undetectable		 2zw9A-2hrvA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHL

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox) 		4 THR C 115
LEU C 122
ASP C 235
SER C 240
 None
 0.97A 2zw9A-2inpC:
undetectable		 2zw9A-2inpC:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF04072
(LCM) 		4 ARG A  81
ASP A 128
ASP A 175
GLU A 201
 None
 0.52A 2zw9A-2ob1A:
31.1		 2zw9A-2ob1A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1

(Sulfolobus
solfataricus) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		4 LYS A  55
LEU A 145
ASP A 149
GLU A 200
 None
 1.09A 2zw9A-2qbyA:
undetectable		 2zw9A-2qbyA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyo HYPOTHETICAL PROTEIN
ML2640

(Mycobacterium
leprae) 		PF04072
(LCM) 		5 THR A  17
ARG A  87
ASP A 132
ASP A 161
GLU A 186
 None
 1.07A 2zw9A-2uyoA:
21.1		 2zw9A-2uyoA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgq SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,MITOCHONDRIA
L
ANTIVIRAL-SIGNALING
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16739
(CARD_2) 		4 THR A  93
LEU A 285
ASP A 287
GLU A 111
 None
None
None
MTT  A1463 (-2.9A)
 1.02A 2zw9A-2vgqA:
undetectable		 2zw9A-2vgqA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		4 THR A  92
LYS A 357
GLU A 129
SER A  84
 None
 0.95A 2zw9A-2vhlA:
undetectable		 2zw9A-2vhlA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl8 CYTOTOXIN L

(Paeniclostridium
sordellii) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		4 ARG A 499
LEU A 511
ASP A 288
GLU A 502
 None
None
CA  A1545 ( 2.8A)
None
 1.08A 2zw9A-2vl8A:
undetectable		 2zw9A-2vl8A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w21 GLUTAMATE 5-KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		4 THR A 216
LEU A 167
ASP A 170
GLU A 135
 None
None
SO4  A1259 (-3.2A)
None
 0.95A 2zw9A-2w21A:
3.0		 2zw9A-2w21A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA

(Escherichia
coli) 		PF02563
(Poly_export)
PF10531
(SLBB) 		4 THR A 330
ARG A  64
LEU A 318
ASP A 322
 None
 0.99A 2zw9A-2w8iA:
undetectable		 2zw9A-2w8iA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Escherichia
coli;
Bovine leukemia
virus) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		4 THR A 119
LEU A 311
ASP A 313
GLU A 137
 None
None
None
MAL  A1488 (-2.9A)
 1.06A 2zw9A-2xz3A:
undetectable		 2zw9A-2xz3A:
21.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		8 THR A  30
LYS A  38
ARG A  88
ASP A 146
LEU A 150
ASP A 196
GLU A 224
SER A 226
 SAH  A 801 (-4.5A)
SAH  A 801 (-2.8A)
SAH  A 801 (-3.9A)
SAH  A 801 (-2.9A)
SAH  A 801 (-4.6A)
SAH  A 801 (-4.1A)
SAH  A 801 (-3.0A)
SAH  A 801 (-4.6A)
 0.23A 2zw9A-2zwaA:
59.3		 2zw9A-2zwaA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1i AMIDASE

(Rhodococcus sp.
N-771) 		PF01425
(Amidase) 		4 THR A 236
ARG A 501
ASP A 271
LEU A 270
 None
 0.96A 2zw9A-3a1iA:
undetectable		 2zw9A-3a1iA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al8 SEMAPHORIN-6A

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		4 THR A 436
ARG A 494
LEU A 312
ASP A 331
 None
 1.03A 2zw9A-3al8A:
5.1		 2zw9A-3al8A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF01048
(PNP_UDP_1) 		4 THR A  85
ASP A  90
ASP A 163
GLU A  98
 None
 0.98A 2zw9A-3bjeA:
3.2		 2zw9A-3bjeA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvw RE11660P

(Drosophila
melanogaster) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 THR A 140
ARG A  17
ASP A 399
LEU A 402
 None
None
None
FAD  A 521 (-4.1A)
 0.85A 2zw9A-3cvwA:
undetectable		 2zw9A-3cvwA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 THR A 145
ARG A 100
ASP A 158
LEU A 159
 GOL  A 804 (-4.8A)
GOL  A 804 ( 4.8A)
None
None
 1.02A 2zw9A-3dlaA:
3.1		 2zw9A-3dlaA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1

(Escherichia
coli;
Arabidopsis
thaliana) 		PF00400
(WD40)
PF01547
(SBP_bac_1) 		4 THR A  93
LEU A 285
ASP A 287
GLU A 111
 None
None
None
GLC  A 672 (-2.8A)
 1.02A 2zw9A-3dm0A:
14.7		 2zw9A-3dm0A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7p PLECTIN-1

(Homo sapiens) 		PF00307
(CH) 		5 ARG A  69
ASP A 269
LEU A 243
ASP A 216
GLU A  66
 None
None
None
EDO  A 294 (-3.6A)
None
 1.48A 2zw9A-3f7pA:
undetectable		 2zw9A-3f7pA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		4 THR A 258
ASP A 552
GLU A 289
SER A 252
 None
 1.06A 2zw9A-3i04A:
2.6		 2zw9A-3i04A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 5

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00346
(Complex1_49kDa)
PF00329
(Complex1_30kDa) 		4 LYS 4 369
LEU 5  49
ASP 5 106
GLU 5 117
 None
 1.10A 2zw9A-3i9v4:
undetectable		 2zw9A-3i9v4:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 THR A 647
ARG A 732
GLU A 588
SER A 725
 None
 1.04A 2zw9A-3iayA:
undetectable		 2zw9A-3iayA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3idv PROTEIN
DISULFIDE-ISOMERASE
A4

(Homo sapiens) 		PF00085
(Thioredoxin) 		4 THR A  81
LEU A 108
ASP A 112
GLU A 166
 None
 1.03A 2zw9A-3idvA:
undetectable		 2zw9A-3idvA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j5y EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1

(Homo sapiens) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 THR A 234
ARG A 198
LEU A 226
SER A 229
 None
 1.02A 2zw9A-3j5yA:
undetectable		 2zw9A-3j5yA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbl NLR FAMILY CARD
DOMAIN-CONTAINING
PROTEIN 4

(Mus musculus) 		no annotation 4 ARG K 745
ASP K 668
GLU K 720
SER K 722
 None
 0.95A 2zw9A-3jblK:
undetectable		 2zw9A-3jblK:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7d GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF03710
(GlnE)
PF08335
(GlnD_UR_UTase) 		4 THR A 524
LEU A 555
GLU A 918
SER A 562
 None
 0.97A 2zw9A-3k7dA:
undetectable		 2zw9A-3k7dA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2j FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PARATHYROID
HORMONE/PARATHYROID
HORMONE-RELATED
PEPTIDE RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		4 THR A-251
LEU A -59
ASP A -57
GLU A-233
 None
None
None
MAL  A 194 (-2.9A)
 1.01A 2zw9A-3l2jA:
undetectable		 2zw9A-3l2jA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mp6 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,LINKER,SAGA-
ASSOCIATED FACTOR 29

(Escherichia
coli;
Saccharomyces
cerevisiae;
unidentified) 		PF07039
(DUF1325)
PF13416
(SBP_bac_8) 		4 THR A 831
LEU A1023
ASP A1025
GLU A 849
 None
None
None
MAL  A 600 (-2.9A)
 1.00A 2zw9A-3mp6A:
undetectable		 2zw9A-3mp6A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzk PROTEIN TRANSPORT
PROTEIN SEC16

(Saccharomyces
cerevisiae) 		PF12931
(Sec16_C)
PF12932
(Sec16) 		4 THR B1268
ASP B1297
ASP B1295
GLU B1301
 None
 0.95A 2zw9A-3mzkB:
undetectable		 2zw9A-3mzkB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		4 THR A-255
LEU A -63
ASP A -61
GLU A-237
 None
None
None
MAL  A5044 (-2.9A)
 1.05A 2zw9A-3n94A:
undetectable		 2zw9A-3n94A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Homo sapiens) 		PF04072
(LCM) 		5 LYS A  37
ARG A  73
ASP A 122
ASP A 171
GLU A 198
 SAM  A 801 (-2.6A)
SAM  A 801 (-3.8A)
SAM  A 801 (-2.7A)
SAM  A 801 (-3.8A)
SAM  A 801 (-3.1A)
 0.36A 2zw9A-3o7wA:
28.0		 2zw9A-3o7wA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0

(Escherichia
coli;
Homo sapiens) 		PF07686
(V-set)
PF13416
(SBP_bac_8) 		4 THR A  93
LEU A 285
ASP A 287
GLU A 111
 None
None
None
MAL  A1122 (-2.9A)
 1.04A 2zw9A-3oaiA:
undetectable		 2zw9A-3oaiA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4

(Saccharomyces
cerevisiae) 		PF11701
(UNC45-central) 		4 THR A 521
ARG A 481
LEU A 502
ASP A 556
 None
 0.90A 2zw9A-3opbA:
undetectable		 2zw9A-3opbA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Escherichia
coli;
Aequorea
victoria) 		PF01353
(GFP)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		4 THR A  93
LEU A 533
ASP A 535
GLU A 111
 None
None
None
MAL  A 700 (-2.9A)
 1.00A 2zw9A-3osqA:
undetectable		 2zw9A-3osqA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		4 THR A 320
LEU A 312
ASP A 315
GLU A 441
 None
 0.90A 2zw9A-3ps5A:
undetectable		 2zw9A-3ps5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpb URIDINE
PHOSPHORYLASE

(Streptococcus
pyogenes) 		PF01048
(PNP_UDP_1) 		4 THR A  70
ASP A 163
GLU A  83
SER A  78
 None
 1.08A 2zw9A-3qpbA:
undetectable		 2zw9A-3qpbA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxf ENDOGLUCANASE

(Escherichia
coli) 		PF01270
(Glyco_hydro_8) 		4 THR A  80
LEU A 144
GLU A  55
SER A  58
 None
 1.05A 2zw9A-3qxfA:
undetectable		 2zw9A-3qxfA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tb2 1-CYS PEROXIREDOXIN

(Plasmodium
yoelii) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 ARG A 152
ASP A  42
ASP A  80
GLU A  50
 None
 0.82A 2zw9A-3tb2A:
undetectable		 2zw9A-3tb2A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tpf ORNITHINE
CARBAMOYLTRANSFERASE

(Campylobacter
jejuni) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LYS A  26
ASP A 131
ASP A 220
GLU A 283
 None
 1.04A 2zw9A-3tpfA:
4.3		 2zw9A-3tpfA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vd8 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
INTERFERON-INDUCIBLE
PROTEIN AIM2

(Escherichia
coli;
Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		4 THR A  93
LEU A 285
ASP A 287
GLU A 111
 None
None
None
MTT  A1205 (-2.9A)
 1.02A 2zw9A-3vd8A:
undetectable		 2zw9A-3vd8A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vw5 CELLOBIOSE
2-EPIMERASE

(Ruminococcus
albus) 		PF07221
(GlcNAc_2-epim) 		4 THR A 248
ARG A 385
LEU A 183
GLU A 381
 None
 0.84A 2zw9A-3vw5A:
undetectable		 2zw9A-3vw5A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyl L-RIBULOSE
3-EPIMERASE

(Mesorhizobium
loti) 		PF01261
(AP_endonuc_2) 		4 THR A  23
LEU A  50
ASP A  44
GLU A  36
 None
 0.97A 2zw9A-3vylA:
undetectable		 2zw9A-3vylA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P
SAR1P

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
PF00025
(Arf) 		4 THR B  54
ASP A 351
LEU B  83
SER A 602
 MG  B1191 ( 3.3A)
None
None
None
 1.06A 2zw9A-4bziB:
undetectable		 2zw9A-4bziB:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 THR A  64
ASP A 549
ASP A 541
GLU A  72
 None
 0.90A 2zw9A-4c30A:
4.9		 2zw9A-4c30A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
26S PROTEASE SUBUNIT
RPT4

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF00004
(AAA) 		4 THR K 279
ARG L 290
LEU K 324
GLU L 293
 None
 1.09A 2zw9A-4cr4K:
undetectable		 2zw9A-4cr4K:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN

(Escherichia
coli;
Mus musculus) 		PF07679
(I-set)
PF13416
(SBP_bac_8) 		4 THR A  94
LEU A 286
ASP A 288
GLU A 112
 None
None
None
MLR  A 500 (-2.2A)
 1.02A 2zw9A-4edqA:
undetectable		 2zw9A-4edqA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA

(Escherichia
coli;
Homo sapiens) 		PF00046
(Homeobox)
PF13416
(SBP_bac_8)
PF16878
(SIX1_SD) 		4 THR A  93
LEU A 285
ASP A 287
GLU A 111
 None
None
None
MAL  A 601 (-2.9A)
 1.02A 2zw9A-4egcA:
undetectable		 2zw9A-4egcA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0w PROTEASE CSPB

(Clostridium
perfringens) 		PF00082
(Peptidase_S8) 		4 LYS B 526
LEU B 430
ASP B 406
GLU B 437
 EDO  B 605 (-2.7A)
None
None
EDO  B 605 (-4.6A)
 0.80A 2zw9A-4i0wB:
2.5		 2zw9A-4i0wB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NACHT, LRR
AND PYD
DOMAINS-CONTAINING
PROTEIN 1

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 THR A  94
LEU A 286
ASP A 288
GLU A 112
 None
None
None
MAL  A 501 (-3.0A)
 1.01A 2zw9A-4ifpA:
undetectable		 2zw9A-4ifpA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irl MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NOVEL PROTEIN
SIMILAR TO
VERTEBRATE GUANYLATE
BINDING PROTEIN
FAMILY

(Escherichia
coli;
Danio rerio) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 THR A  94
LEU A 286
ASP A 288
GLU A 112
 None
None
None
MTT  A 501 (-2.9A)
 1.07A 2zw9A-4irlA:
undetectable		 2zw9A-4irlA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwh TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE

(Schizosaccharomyces
pombe) 		PF01746
(tRNA_m1G_MT) 		4 THR A 120
LEU A  99
ASP A 104
SER A 114
 None
 1.00A 2zw9A-4jwhA:
undetectable		 2zw9A-4jwhA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli;
Mycobacterium
tuberculosis) 		PF08817
(YukD)
PF13416
(SBP_bac_8) 		4 THR A  94
LEU A 286
ASP A 288
GLU A 112
 None
None
None
MAL  A 501 (-3.0A)
 1.04A 2zw9A-4kv3A:
undetectable		 2zw9A-4kv3A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2i NON-LEE ENCODED TYPE
III EFFECTOR C

(Citrobacter
rodentium) 		PF13678
(Peptidase_M85) 		4 LEU A  84
ASP A  92
GLU A  47
SER A  45
 None
 1.10A 2zw9A-4o2iA:
undetectable		 2zw9A-4o2iA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pn0 MRNA-CAPPING ENZYME
SUBUNIT BETA

(Schizosaccharomyces
pombe) 		PF02940
(mRNA_triPase) 		4 THR A  58
ARG A 296
LEU A  65
ASP A 268
 None
 1.05A 2zw9A-4pn0A:
undetectable		 2zw9A-4pn0A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvc NADPH-DEPENDENT
METHYLGLYOXAL
REDUCTASE GRE2

(Saccharomyces
cerevisiae) 		PF01073
(3Beta_HSD) 		4 THR A 331
LEU A 279
ASP A 274
GLU A 218
 None
 1.01A 2zw9A-4pvcA:
5.1		 2zw9A-4pvcA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1z PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF16215
(DUF4876) 		4 THR A 398
ASP A 216
GLU A 223
SER A 220
 None
None
UNX  A 401 ( 3.4A)
None
 0.82A 2zw9A-4q1zA:
undetectable		 2zw9A-4q1zA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA

(Escherichia
coli;
Mus musculus) 		PF13416
(SBP_bac_8)
PF13621
(Cupin_8) 		4 THR A-278
LEU A -86
ASP A -84
GLU A-260
 None
None
None
GLC  A 901 (-3.1A)
 1.06A 2zw9A-4qszA:
undetectable		 2zw9A-4qszA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF04901
(RAMP)
PF13416
(SBP_bac_8) 		4 THR A  95
LEU A 287
ASP A 289
GLU A 113
 None
None
None
MAL  A2201 (-3.0A)
 1.00A 2zw9A-4rwfA:
undetectable		 2zw9A-4rwfA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE

(Leishmania
mexicana) 		PF00155
(Aminotran_1_2) 		4 THR A  92
ARG A 315
ASP A 198
GLU A 319
 None
 1.01A 2zw9A-4wb0A:
3.6		 2zw9A-4wb0A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB

(Escherichia
coli;
Staphylococcus
aureus) 		PF00717
(Peptidase_S24)
PF13416
(SBP_bac_8) 		4 THR A  99
LEU A 291
ASP A 293
GLU A 117
 None
None
None
MAL  A 601 (-2.9A)
 1.08A 2zw9A-4wviA:
undetectable		 2zw9A-4wviA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjx HSDR

(Escherichia
coli) 		PF04313
(HSDR_N)
PF04851
(ResIII)
PF12008
(EcoR124_C) 		4 THR A 661
LEU A 677
GLU A 597
SER A 595
 None
 1.05A 2zw9A-4xjxA:
2.4		 2zw9A-4xjxA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA

(Methanothermobacter
marburgensis) 		PF02240
(MCR_gamma) 		4 THR C 143
ARG C 104
ASP C  36
SER C 137
 None
 0.94A 2zw9A-5a8rC:
undetectable		 2zw9A-5a8rC:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5crv TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 23
SIGNAL TRANSDUCING
ADAPTER MOLECULE 2

(Homo sapiens;
Homo sapiens) 		PF03097
(BRO1)
no annotation 		4 ARG A   6
LEU C 358
GLU A 191
SER A 193
 None
 1.08A 2zw9A-5crvA:
undetectable		 2zw9A-5crvA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwe CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		4 THR A 103
LEU A 149
ASP A 201
GLU A 108
 None
 1.01A 2zw9A-5cweA:
undetectable		 2zw9A-5cweA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl7 PORIN

(Acinetobacter
baumannii) 		PF03573
(OprD) 		4 ARG A 250
ASP A 339
LEU A 341
ASP A 345
 C8E  A 511 (-2.9A)
None
None
None
 0.80A 2zw9A-5dl7A:
undetectable		 2zw9A-5dl7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 THR A 489
ARG A 178
LEU A 521
GLU A 492
 None
 1.08A 2zw9A-5gz4A:
undetectable		 2zw9A-5gz4A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7n NLRP12-PYD WITH MBP
TAG

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		4 THR A  94
LEU A 286
ASP A 288
GLU A 112
 None
None
None
MTT  A 501 (-2.9A)
 1.07A 2zw9A-5h7nA:
undetectable		 2zw9A-5h7nA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm0 ALPHA-MANNOSIDASE,AL
PHA-MANNOSIDASE,ALPH
A-MANNOSIDASE

(Saccharomyces
cerevisiae) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 ARG A 394
ASP A 604
GLU A 995
SER A 610
 None
 1.02A 2zw9A-5jm0A:
undetectable		 2zw9A-5jm0A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 LEU A 429
ASP A 424
GLU A 340
SER A 417
 None
None
BXP  A 509 ( 4.8A)
None
 0.96A 2zw9A-5l6fA:
undetectable		 2zw9A-5l6fA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE ALPHA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 ARG b 641
ASP b 405
LEU b 401
GLU b 447
 None
 0.98A 2zw9A-5l9wb:
undetectable		 2zw9A-5l9wb:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loz EPSIN-1

(Saccharomyces
cerevisiae) 		PF01417
(ENTH) 		4 THR A 130
LEU A  77
ASP A  60
GLU A 107
 None
 1.07A 2zw9A-5lozA:
undetectable		 2zw9A-5lozA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mea CELL DIVISION CYCLE
PROTEIN CDT1

(Saccharomyces
cerevisiae) 		no annotation 4 ARG A 399
LEU A 340
ASP A 358
GLU A 322
 None
 1.00A 2zw9A-5meaA:
undetectable		 2zw9A-5meaA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyp STRUCTURAL PROTEIN
VP2
STRUCTURAL PROTEIN
VP3

(Sacbrood virus;
Sacbrood virus) 		no annotation
no annotation 		4 THR C  66
ARG C  89
LEU B 203
ASP B  77
 None
 1.07A 2zw9A-5oypC:
undetectable		 2zw9A-5oypC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF04598
(Gasdermin)
PF13416
(SBP_bac_8) 		4 THR A  93
LEU A 285
ASP A 287
GLU A 111
 None
None
None
MAL  A1501 (-3.0A)
 1.01A 2zw9A-5tj2A:
undetectable		 2zw9A-5tj2A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN

(Escherichia
coli;
Streptococcus
pyogenes) 		PF12892
(FctA)
PF13416
(SBP_bac_8) 		4 THR A  99
LEU A 291
ASP A 293
GLU A 117
 None
None
None
MLR  A 501 (-2.8A)
 0.98A 2zw9A-5ttdA:
undetectable		 2zw9A-5ttdA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE

(Homo sapiens) 		PF04095
(NAPRTase) 		4 THR A 218
ARG A 477
LEU A 386
SER A 209
 None
 0.87A 2zw9A-5u2nA:
undetectable		 2zw9A-5u2nA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR

(Escherichia
coli;
Homo sapiens) 		no annotation 4 THR A  95
LEU A 287
ASP A 289
GLU A 113
 None
None
None
MAL  A2201 (-3.2A)
 1.00A 2zw9A-5v6yA:
undetectable		 2zw9A-5v6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq6 MBP TAGGED HMNDA-PYD

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		4 THR A  94
LEU A 286
ASP A 288
GLU A 112
 None
None
None
MAL  A 501 (-2.9A)
 1.08A 2zw9A-5wq6A:
undetectable		 2zw9A-5wq6A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus) 		no annotation 4 THR A 359
LEU A 389
GLU A 327
SER A 354
 None
 0.92A 2zw9A-5ybbA:
undetectable		 2zw9A-5ybbA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage JBD30) 		no annotation 4 THR A 173
LEU A 365
ASP A 367
GLU A 191
 None
None
None
MTT  A 501 (-2.7A)
 1.04A 2zw9A-6anvA:
undetectable		 2zw9A-6anvA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b12 TNE2

(Pseudomonas
protegens) 		no annotation 4 THR A 375
LEU A 378
ASP A 350
GLU A 389
 None
 0.80A 2zw9A-6b12A:
undetectable		 2zw9A-6b12A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE

(Escherichia
coli) 		no annotation 4 LEU A 126
ASP A 121
GLU A 341
SER A 340
 None
 1.07A 2zw9A-6bqcA:
4.2		 2zw9A-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dm8 -

(-) 		no annotation 4 THR A-122
LEU A  70
ASP A  72
GLU A-104
 None
None
None
MAL  A 402 (-3.0A)
 1.04A 2zw9A-6dm8A:
undetectable		 2zw9A-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eh1 STRUCTURAL PROTEIN
VP2
STRUCTURAL PROTEIN
VP3

(Sacbrood virus;
Sacbrood virus) 		no annotation
no annotation 		4 THR C  66
ARG C  89
LEU B 203
ASP B  77
 None
 1.06A 2zw9A-6eh1C:
undetectable		 2zw9A-6eh1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejf


(;
) 		no annotation
no annotation 		4 LYS J 175
LEU G 431
ASP G 401
GLU J 217
 None
 1.10A 2zw9A-6ejfJ:
undetectable		 2zw9A-6ejfJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn0 -

(-) 		no annotation 4 THR A 135
ARG A  16
ASP A 391
LEU A 394
 None
None
None
FAD  A 501 (-3.8A)
 0.85A 2zw9A-6fn0A:
undetectable		 2zw9A-6fn0A:
undetectable