SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZVJ_A_SAMA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bnk PROTEIN
(3-METHYLADENINE DNA
GLYCOSYLASE)

(Homo sapiens) 		PF02245
(Pur_DNA_glyco) 		5 MET A 168
ASN A 169
GLY A 154
TYR A 157
ARG A  85
 None
 1.37A 2zvjA-1bnkA:
undetectable		 2zvjA-1bnkA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		5 GLY A 320
TYR A 318
TYR A 487
MET A 299
HIS A 500
 None
 1.41A 2zvjA-1r6vA:
2.0		 2zvjA-1r6vA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sus CAFFEOYL-COA
O-METHYLTRANSFERASE

(Medicago sativa) 		PF01596
(Methyltransf_3) 		6 MET A  61
GLU A  85
GLY A  87
TYR A  89
TYR A  92
ASN A 113
 SPF  A 401 (-4.1A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.7A)
None
None
 0.77A 2zvjA-1susA:
21.7		 2zvjA-1susA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkz PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermotoga
maritima) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 VAL A  62
GLU A  15
TYR A  32
HIS A  16
ARG A  40
 None
 1.21A 2zvjA-1vkzA:
3.6		 2zvjA-1vkzA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bku IMPORTIN BETA-1
SUBUNIT

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 MET B 682
ASN B 683
VAL B 684
TYR B 720
MET B 725
 None
 1.41A 2zvjA-2bkuB:
undetectable		 2zvjA-2bkuB:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akf PUTATIVE SECRETED
ALPHA
L-ARABINOFURANOSIDAS
E II

(Streptomyces
avermitilis) 		PF04616
(Glyco_hydro_43)
PF05270
(AbfB) 		5 ASN A 422
GLU A 419
GLY A 425
TYR A 423
TYR A 421
 None
 1.36A 2zvjA-3akfA:
undetectable		 2zvjA-3akfA:
19.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bwm CATECHOL
O-METHYLTRANSFERASE

(Homo sapiens) 		PF01596
(Methyltransf_3) 		11 MET A  40
ASN A  41
VAL A  42
GLU A  64
GLY A  66
TYR A  68
TYR A  71
ASN A  92
HIS A 142
TRP A 143
ARG A 146
 SAM  A 301 (-3.7A)
SAM  A 301 (-4.7A)
SAM  A 301 ( 3.7A)
SAM  A 301 ( 4.1A)
SAM  A 301 (-3.2A)
SAM  A 301 (-4.7A)
None
None
SAM  A 301 ( 4.9A)
SAM  A 301 ( 3.4A)
None
 0.32A 2zvjA-3bwmA:
39.7		 2zvjA-3bwmA:
80.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE

(Oenococcus oeni) 		PF12697
(Abhydrolase_6) 		5 VAL A 219
GLY A 243
TYR A 221
ASN A 240
HIS A 133
 None
 1.40A 2zvjA-3fsgA:
2.8		 2zvjA-3fsgA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 5 MET X 412
ASN X 413
GLY X 437
HIS X 464
ARG X 496
 None
 1.45A 2zvjA-3kvnX:
1.4		 2zvjA-3kvnX:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntv MW1564 PROTEIN

(Staphylococcus
aureus) 		PF01596
(Methyltransf_3) 		5 VAL A  55
GLU A  77
GLY A  79
TYR A  84
ASN A 104
 SO4  A 233 (-4.2A)
SO4  A 233 (-4.0A)
None
SO4  A 233 (-4.9A)
None
 0.49A 2zvjA-3ntvA:
21.4		 2zvjA-3ntvA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up4 OTEMO

(Pseudomonas
putida) 		PF00743
(FMO-like) 		5 VAL A 198
GLY A  55
TYR A 344
TRP A 170
ARG A  52
 None
 1.29A 2zvjA-3up4A:
2.6		 2zvjA-3up4A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvt POST-PROLINE
CLEAVING ENZYME

(Rickettsia
typhi) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 ASN A 263
VAL A 243
TYR A 269
MET A 288
TRP A 304
 None
 1.36A 2zvjA-4hvtA:
undetectable		 2zvjA-4hvtA:
14.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p58 CATECHOL
O-METHYLTRANSFERASE

(Mus musculus) 		PF01596
(Methyltransf_3) 		6 GLU A 107
GLY A 109
TYR A 114
ASN A 135
HIS A 185
ARG A 189
 None
2F6  A 301 (-3.6A)
None
None
None
None
 0.53A 2zvjA-4p58A:
33.3		 2zvjA-4p58A:
97.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p58 CATECHOL
O-METHYLTRANSFERASE

(Mus musculus) 		PF01596
(Methyltransf_3) 		5 GLU A 107
GLY A 109
TYR A 138
HIS A 185
ARG A 189
 None
2F6  A 301 (-3.6A)
None
None
None
 1.02A 2zvjA-4p58A:
33.3		 2zvjA-4p58A:
97.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4sli INTRAMOLECULAR
TRANS-SIALIDASE

(Macrobdella
decora) 		PF02973
(Sialidase)
PF13088
(BNR_2) 		5 ASN A 324
GLY A 314
TYR A 313
ASN A 353
ARG A 358
 None
 1.44A 2zvjA-4sliA:
undetectable		 2zvjA-4sliA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u02 AMINO ACID ABC
TRANSPORTER,
ATP-BINDING PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran) 		5 MET A 211
VAL A 217
GLY A  22
HIS A  24
ARG A   8
 None
 1.47A 2zvjA-4u02A:
undetectable		 2zvjA-4u02A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x6k ANHYDROSIALIDASE

([Ruminococcus]
gnavus) 		PF13088
(BNR_2) 		5 ASN A 288
GLY A 278
TYR A 277
ASN A 317
ARG A 322
 None
 1.46A 2zvjA-4x6kA:
undetectable		 2zvjA-4x6kA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 VAL A 526
GLU A 902
TYR A 657
ASN A 601
ARG A 604
 None
 1.42A 2zvjA-5iy9A:
undetectable		 2zvjA-5iy9A:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jif HEMAGGLUTININ-ESTERA
SE

(Murine
coronavirus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		5 GLU A 105
GLY A 106
TYR A  92
TRP A 301
ARG A 300
 None
None
None
None
NAG  A 818 (-3.7A)
 1.40A 2zvjA-5jifA:
undetectable		 2zvjA-5jifA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kva CAFFEOYL-COA
O-METHYLTRANSFERASE

(Sorghum bicolor) 		PF01596
(Methyltransf_3) 		5 GLU A  99
GLY A 101
TYR A 103
TYR A 106
ASN A 127
 SAM  A 301 ( 4.0A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.8A)
None
None
 0.57A 2zvjA-5kvaA:
21.8		 2zvjA-5kvaA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kva CAFFEOYL-COA
O-METHYLTRANSFERASE

(Sorghum bicolor) 		PF01596
(Methyltransf_3) 		5 MET A  75
GLU A  99
GLY A 101
TYR A 103
ASN A 127
 SAM  A 301 (-3.8A)
SAM  A 301 ( 4.0A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.8A)
None
 0.60A 2zvjA-5kvaA:
21.8		 2zvjA-5kvaA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n11 HEMAGGLUTININ-ESTERA
SE

(Betacoronavirus
1) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		5 GLU A 101
GLY A 102
TYR A  88
TRP A 292
ARG A 291
 None
None
None
None
NAG  A 511 (-3.8A)
 1.42A 2zvjA-5n11A:
undetectable		 2zvjA-5n11A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqf APICAL MEMBRANE
ANTIGEN 1

(Plasmodium
falciparum) 		PF02430
(AMA-1) 		5 ASN A 293
VAL A 294
MET A 224
ASN A 225
HIS A 220
 ASN  A 293 ( 0.6A)
VAL  A 294 ( 0.6A)
MET  A 224 ( 0.0A)
ASN  A 225 ( 0.6A)
HIS  A 220 ( 1.0A)
 1.49A 2zvjA-5nqfA:
undetectable		 2zvjA-5nqfA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N) 		4 GLU A  88
SER A 100
GLN A 101
ASP A  81
 None
 1.22A 2zvjA-1fi4A:
0.5		 2zvjA-1fi4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 TYR A 873
SER A 859
GLN A 787
ASP A 863
 None
 1.24A 2zvjA-1hn0A:
0.0		 2zvjA-1hn0A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mz5 SIALIDASE

(Trypanosoma
rangeli) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		4 SER A  58
GLU A 358
TYR A 343
ASP A 363
 None
 1.27A 2zvjA-1mz5A:
0.0		 2zvjA-1mz5A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ndf CARNITINE
ACETYLTRANSFERASE

(Mus musculus) 		PF00755
(Carn_acyltransf) 		4 TYR A  50
SER A 470
GLN A 438
ASP A 466
 None
 1.39A 2zvjA-1ndfA:
0.0		 2zvjA-1ndfA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfe HYPOTHETICAL PROTEIN
RV2991

(Mycobacterium
tuberculosis) 		PF01243
(Putative_PNPOx) 		4 SER A  22
SER A 144
GLN A   5
ASP A  18
 None
 1.38A 2zvjA-1rfeA:
0.0		 2zvjA-1rfeA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg1 TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER
16

(Rattus
norvegicus) 		PF00020
(TNFR_c6) 		4 SER X 127
SER X 109
GLN X 111
ASP X 134
 None
 1.39A 2zvjA-1sg1X:
0.0		 2zvjA-1sg1X:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwi BETA-GALACTOSIDASE

(Sulfolobus
solfataricus) 		PF00232
(Glyco_hydro_1) 		4 SER A 265
GLU A 362
TYR A 340
SER A 357
 None
 1.40A 2zvjA-1uwiA:
0.0		 2zvjA-1uwiA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xaj 3-DEHYDROQUINATE
SYNTHASE

(Staphylococcus
aureus) 		PF01761
(DHQ_synthase) 		4 GLU A 249
TYR A 250
SER A 174
GLN A 171
 NAD  A 400 ( 4.8A)
None
NAD  A 400 ( 4.5A)
NAD  A 400 (-3.6A)
 1.25A 2zvjA-1xajA:
3.3		 2zvjA-1xajA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 SER A  52
GLU A  58
SER A 591
GLN A 580
 None
 1.40A 2zvjA-1xc6A:
0.2		 2zvjA-1xc6A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhf HYPOTHETICAL PROTEIN
SPY1581

(Streptococcus
pyogenes) 		PF07883
(Cupin_2) 		4 TYR A  96
SER A  43
GLN A 102
ASP A  24
 None
 1.22A 2zvjA-1yhfA:
undetectable		 2zvjA-1yhfA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztv HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF01904
(DUF72) 		4 SER A  92
TYR A  78
SER A  70
GLN A  72
 None
 1.25A 2zvjA-1ztvA:
undetectable		 2zvjA-1ztvA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zwx SPHINGOMYELINASE-C

(Listeria
ivanovii) 		PF03372
(Exo_endo_phos) 		4 GLU A  88
TYR A  53
GLN A 187
ASP A 282
 PO4  A 401 (-3.2A)
None
None
None
 1.39A 2zvjA-1zwxA:
undetectable		 2zvjA-1zwxA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 SER A  60
GLU A 192
TYR A 359
SER A 168
 None
FAD  A4750 ( 4.3A)
FAD  A4750 (-4.4A)
FAD  A4750 ( 4.0A)
 1.11A 2zvjA-1zy8A:
undetectable		 2zvjA-1zy8A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bji INOSITOL-1(OR
4)-MONOPHOSPHATASE

(Bos taurus) 		PF00459
(Inositol_P) 		4 SER A1079
GLU A1070
SER A1037
ASP A1274
 None
MG  A2279 ( 2.6A)
None
None
 1.24A 2zvjA-2bjiA:
undetectable		 2zvjA-2bjiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddt SPHINGOMYELIN
PHOSPHODIESTERASE

(Bacillus cereus) 		PF03372
(Exo_endo_phos) 		4 GLU A  53
TYR A  18
GLN A 153
ASP A 253
 MG  A 310 (-2.4A)
None
None
None
 1.38A 2zvjA-2ddtA:
undetectable		 2zvjA-2ddtA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drq XYLANASE Y

(Bacillus
halodurans) 		PF01270
(Glyco_hydro_8) 		4 GLU A 131
TYR A 132
SER A 226
ASP A 195
 None
 1.35A 2zvjA-2drqA:
undetectable		 2zvjA-2drqA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihm DNA POLYMERASE MU

(Mus musculus) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		4 SER A 188
GLU A 445
TYR A 141
SER A 178
 None
 1.39A 2zvjA-2ihmA:
undetectable		 2zvjA-2ihmA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iny HEXON PROTEIN

(Fowl
aviadenovirus A) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 SER A 684
SER A 673
GLN A 563
ASP A 857
 None
 1.36A 2zvjA-2inyA:
undetectable		 2zvjA-2inyA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iny HEXON PROTEIN

(Fowl
aviadenovirus A) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 SER A 684
TYR A 763
SER A 673
GLN A 563
 None
 1.25A 2zvjA-2inyA:
undetectable		 2zvjA-2inyA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc4 EXODEOXYRIBONUCLEASE
III

(Neisseria
meningitidis) 		PF03372
(Exo_endo_phos) 		4 TYR A  62
SER A  57
GLN A  39
ASP A  86
 2HP  A1261 ( 4.0A)
None
None
None
 1.31A 2zvjA-2jc4A:
undetectable		 2zvjA-2jc4A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF00156
(Pribosyltran) 		4 SER A  67
GLU A 194
TYR A 191
SER A  74
 MG  A 302 ( 3.8A)
5GP  A 300 (-2.7A)
5GP  A 300 (-4.6A)
None
 1.22A 2zvjA-2jkyA:
4.1		 2zvjA-2jkyA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nt2 PROTEIN PHOSPHATASE
SLINGSHOT HOMOLOG 2

(Homo sapiens) 		PF00782
(DSPc) 		4 GLU A 362
TYR A 360
SER A 434
GLN A 438
 None
 1.35A 2zvjA-2nt2A:
undetectable		 2zvjA-2nt2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron) 		PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 TYR A 846
SER A 832
GLN A 771
ASP A 836
 None
 1.38A 2zvjA-2q1fA:
undetectable		 2zvjA-2q1fA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqp LARGE CAPSID PROTEIN

(Providence
virus) 		PF03566
(Peptidase_A21) 		4 SER A 435
GLU A 428
GLN A 544
ASP A 555
 None
 1.15A 2zvjA-2qqpA:
undetectable		 2zvjA-2qqpA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkp NPH1-1, RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1

(Avena sativa;
Homo sapiens) 		PF00071
(Ras)
PF13426
(PAS_9) 		4 GLU A 699
TYR A 682
SER A 701
ASP A 664
 None
None
GTP  A1724 (-3.6A)
None
 1.35A 2zvjA-2wkpA:
undetectable		 2zvjA-2wkpA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znw SCFV10

(Mus musculus;
synthetic
construct) 		PF07686
(V-set) 		4 SER A 184
TYR A 169
GLN A   6
ASP A   1
 None
 1.38A 2zvjA-2znwA:
undetectable		 2zvjA-2znwA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abs ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN

(Escherichia
coli) 		PF05985
(EutC) 		4 SER B 289
GLU B 210
TYR B 241
ASP B 255
 None
 1.40A 2zvjA-3absB:
undetectable		 2zvjA-3absB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afl OLIGO ALGINATE LYASE

(Agrobacterium
fabrum) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		4 SER A 350
TYR A 365
SER A 524
GLN A 536
 None
LGU  A1002 (-3.5A)
None
None
 1.15A 2zvjA-3aflA:
undetectable		 2zvjA-3aflA:
15.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bwm CATECHOL
O-METHYLTRANSFERASE

(Homo sapiens) 		PF01596
(Methyltransf_3) 		5 SER A  72
GLU A  90
SER A 119
GLN A 120
ASP A 141
 SAM  A 301 (-2.9A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.6A)
MG  A 300 (-2.4A)
 0.23A 2zvjA-3bwmA:
39.7		 2zvjA-3bwmA:
80.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3by9 SENSOR PROTEIN

(Vibrio cholerae) 		PF02743
(dCache_1) 		4 SER A  46
GLU A 248
GLN A  32
ASP A  43
 None
 1.16A 2zvjA-3by9A:
undetectable		 2zvjA-3by9A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlt ESTERASE D

(Lactobacillus
rhamnosus) 		PF12146
(Hydrolase_4) 		4 TYR A  24
SER A 117
GLN A 184
ASP A  30
 None
 1.38A 2zvjA-3dltA:
undetectable		 2zvjA-3dltA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ds8 LIN2722 PROTEIN

(Listeria
innocua) 		PF06028
(DUF915) 		4 SER A 195
SER A  12
GLN A  70
ASP A 136
 None
SO4  A 255 ( 2.6A)
None
None
 1.41A 2zvjA-3ds8A:
undetectable		 2zvjA-3ds8A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epc PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		4 GLU 2 259
TYR 2  41
SER 2 217
ASP 2  44
 None
 1.30A 2zvjA-3epc2:
undetectable		 2zvjA-3epc2:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfv UNCHARACTERIZED ABC
TRANSPORTER
SOLUTE-BINDING
PROTEIN YCLQ

(Bacillus
subtilis) 		PF01497
(Peripla_BP_2) 		4 SER A 245
TYR A 275
SER A 217
ASP A 181
 None
PO4  A 304 (-4.5A)
None
None
 1.34A 2zvjA-3gfvA:
undetectable		 2zvjA-3gfvA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib3 COCE/NOND FAMILY
HYDROLASE

(Staphylococcus
aureus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 SER A 136
GLU A 144
SER A 180
GLN A 257
 None
 1.17A 2zvjA-3ib3A:
undetectable		 2zvjA-3ib3A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jug BETA-MANNANASE

(Bacillus sp.
N16-5) 		PF00150
(Cellulase) 		4 SER A 297
GLU A  76
SER A  68
ASP A 299
 None
 1.27A 2zvjA-3jugA:
undetectable		 2zvjA-3jugA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4x PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 SER A 756
SER A 583
GLN A 572
ASP A 774
 None
 1.36A 2zvjA-3k4xA:
undetectable		 2zvjA-3k4xA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 4 SER X 584
GLU X 547
SER X 469
ASP X 328
 None
 1.03A 2zvjA-3kvnX:
undetectable		 2zvjA-3kvnX:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kya PUTATIVE PHOSPHATASE

(Bacteroides
thetaiotaomicron) 		PF01833
(TIG) 		4 SER A  95
SER A 445
GLN A 451
ASP A 458
 EDO  A   2 ( 2.7A)
None
None
EDO  A   2 (-3.7A)
 1.23A 2zvjA-3kyaA:
undetectable		 2zvjA-3kyaA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvv GLUTAMATE--CYSTEINE
LIGASE

(Saccharomyces
cerevisiae) 		PF03074
(GCS) 		4 TYR A 507
SER A 536
GLN A 564
ASP A 540
 None
 1.22A 2zvjA-3lvvA:
undetectable		 2zvjA-3lvvA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqm PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L

(Homo sapiens) 		PF00439
(Bromodomain) 		4 SER A2453
TYR A2538
GLN A2548
ASP A2449
 None
 1.17A 2zvjA-3mqmA:
undetectable		 2zvjA-3mqmA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum) 		PF00374
(NiFeSe_Hases) 		4 SER B1551
GLU B1276
TYR B1424
GLN B1522
 None
 1.34A 2zvjA-3myrB:
undetectable		 2zvjA-3myrB:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr HYDROGENASE (NIFE)
SMALL SUBUNIT HYDA
NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum;
Allochromatium
vinosum) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
PF00374
(NiFeSe_Hases) 		4 SER A 204
GLU A 208
SER B1230
ASP A 206
 None
 1.28A 2zvjA-3myrA:
undetectable		 2zvjA-3myrA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhe UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2

(Homo sapiens) 		PF00443
(UCH) 		4 SER A 421
SER A 442
GLN A 359
ASP A 436
 None
 1.31A 2zvjA-3nheA:
undetectable		 2zvjA-3nheA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozy PUTATIVE MANDELATE
RACEMASE

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 SER A 144
GLU A 254
SER A 279
ASP A 331
 None
MG  A 390 (-2.6A)
None
None
 1.27A 2zvjA-3ozyA:
undetectable		 2zvjA-3ozyA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF06824
(Glyco_hydro_125) 		4 SER A 348
GLU A 288
SER A 212
ASP A 219
 None
 1.36A 2zvjA-3qpfA:
undetectable		 2zvjA-3qpfA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6n DESMOPLAKIN

(Homo sapiens) 		no annotation 4 GLU A 293
TYR A 296
GLN A 318
ASP A 369
 None
None
DTT  A   3 (-3.6A)
None
 1.36A 2zvjA-3r6nA:
undetectable		 2zvjA-3r6nA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5w L-ORNITHINE
5-MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF13434
(K_oxygenase) 		4 SER A 149
TYR A 126
SER A 167
GLN A 395
 None
 1.41A 2zvjA-3s5wA:
3.2		 2zvjA-3s5wA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7v METHYLORNITHINE
SYNTHASE PYLB

(Methanosarcina
barkeri) 		PF04055
(Radical_SAM) 		4 SER A 222
GLU A 171
TYR A 169
SER A  76
 None
SAM  A 992 (-2.8A)
SAM  A 992 ( 4.6A)
None
 1.40A 2zvjA-3t7vA:
undetectable		 2zvjA-3t7vA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tek THERMODBP-SINGLE
STRANDED DNA BINDING
PROTEIN

(Thermoproteus
tenax) 		no annotation 4 SER A  63
GLU A  12
SER A 119
GLN A 139
 None
 1.34A 2zvjA-3tekA:
undetectable		 2zvjA-3tekA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urh DIHYDROLIPOYL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 SER A  56
GLU A 189
TYR A 354
SER A 165
 None
FAD  A 500 ( 4.5A)
FAD  A 500 (-4.5A)
FAD  A 500 (-3.5A)
 1.17A 2zvjA-3urhA:
undetectable		 2zvjA-3urhA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		4 SER A  49
TYR A  93
SER A 263
ASP A 324
 None
 1.37A 2zvjA-3va6A:
undetectable		 2zvjA-3va6A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcy INTERFERON
ALPHA/BETA RECEPTOR
1

(Mus musculus) 		PF01108
(Tissue_fac)
PF09294
(Interfer-bind) 		4 SER A 245
GLU A 106
SER A 103
ASP A 126
 None
 1.28A 2zvjA-3wcyA:
undetectable		 2zvjA-3wcyA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwr PROTEIN
CORRESPONDING TO
LOCUS C5321 FROM
CFT073 E.COLI STRAIN

(Escherichia
coli) 		PF08238
(Sel1) 		4 SER A 219
TYR A 240
SER A 232
ASP A 204
 None
EDO  A1494 (-3.9A)
EDO  A1493 ( 3.7A)
None
 1.29A 2zvjA-4bwrA:
undetectable		 2zvjA-4bwrA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)

(Mycobacterium
tuberculosis) 		PF07993
(NAD_binding_4) 		4 GLU A 236
TYR A 190
SER A 215
ASP A 195
 None
 1.29A 2zvjA-4dqvA:
undetectable		 2zvjA-4dqvA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4el8 GLYCOSIDE HYDROLASE
FAMILY 48

(Caldicellulosiruptor
bescii) 		PF02011
(Glyco_hydro_48) 		4 SER A 343
TYR A 267
GLN A 325
ASP A 349
 None
 1.36A 2zvjA-4el8A:
undetectable		 2zvjA-4el8A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 GLU A 297
TYR A 296
SER A 284
ASP A1166
 None
 1.21A 2zvjA-4f4cA:
undetectable		 2zvjA-4f4cA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6t MOLYBDENUM STORAGE
PROTEIN SUBUNIT
ALPHA
MOLYBDENUM STORAGE
PROTEIN SUBUNIT BETA

(Azotobacter
vinelandii;
Azotobacter
vinelandii) 		PF00696
(AA_kinase)
PF00696
(AA_kinase) 		4 GLU A 159
TYR A 155
SER A 163
GLN B  23
 None
 1.36A 2zvjA-4f6tA:
3.4		 2zvjA-4f6tA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hte NICKING ENZYME

(Staphylococcus
aureus) 		no annotation 4 SER A 402
SER A 565
GLN A 553
ASP A 397
 None
 1.32A 2zvjA-4hteA:
undetectable		 2zvjA-4hteA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcm CYCLODEXTRIN
GLUCANOTRANSFERASE

([Bacillus]
clarkii) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 SER A 205
TYR A 165
SER A 139
ASP A 101
 None
 0.99A 2zvjA-4jcmA:
undetectable		 2zvjA-4jcmA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		4 GLU A 552
TYR A  39
GLN A 628
ASP A 654
 None
 1.34A 2zvjA-4k0eA:
undetectable		 2zvjA-4k0eA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		4 SER A  74
GLU A  94
SER A  69
ASP A  51
 None
 1.35A 2zvjA-4kngA:
undetectable		 2zvjA-4kngA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4r LPS-ASSEMBLY PROTEIN
LPTD

(Salmonella
enterica) 		PF04453
(OstA_C) 		4 GLU A 426
SER A 389
GLN A 376
ASP A 422
 None
 1.14A 2zvjA-4n4rA:
undetectable		 2zvjA-4n4rA:
16.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p58 CATECHOL
O-METHYLTRANSFERASE

(Mus musculus) 		PF01596
(Methyltransf_3) 		5 GLU A 133
TYR A 138
SER A 162
GLN A 163
ASP A 184
 2F6  A 301 (-2.7A)
None
2F6  A 301 (-3.2A)
2F6  A 301 (-3.8A)
None
 0.61A 2zvjA-4p58A:
33.3		 2zvjA-4p58A:
97.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p58 CATECHOL
O-METHYLTRANSFERASE

(Mus musculus) 		PF01596
(Methyltransf_3) 		5 SER A 115
GLU A 133
TYR A 138
SER A 162
ASP A 184
 None
2F6  A 301 (-2.7A)
None
2F6  A 301 (-3.2A)
None
 0.74A 2zvjA-4p58A:
33.3		 2zvjA-4p58A:
97.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6q MSX2-INTERACTING
PROTEIN

(Homo sapiens) 		PF00076
(RRM_1) 		4 SER A 602
SER A 591
GLN A 482
ASP A 549
 None
 1.41A 2zvjA-4p6qA:
undetectable		 2zvjA-4p6qA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pls ARM00010

(synthetic
construct) 		PF00514
(Arm) 		4 SER A  40
GLU A  72
SER A  30
GLN A  26
 None
 1.14A 2zvjA-4plsA:
undetectable		 2zvjA-4plsA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0v FE-HYDROGENASE

(Chlamydomonas
reinhardtii) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C) 		4 SER A 230
GLU A 178
TYR A 485
SER A 180
 None
 1.32A 2zvjA-4r0vA:
undetectable		 2zvjA-4r0vA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v19 MITORIBOSOMAL
PROTEIN BL32M,
MRPL32

(Sus scrofa) 		PF01783
(Ribosomal_L32p) 		4 GLU 5 163
TYR 5 160
SER 5 166
GLN 5 168
 None
 1.26A 2zvjA-4v195:
undetectable		 2zvjA-4v195:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zem TRANSLATION
INITIATION FACTOR
EIF2B-LIKE
PROTEIN,TRANSLATION
INITIATION FACTOR
EIF2B-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF01008
(IF-2B) 		4 SER A 346
GLU A 339
GLN A 416
ASP A 343
 None
 1.32A 2zvjA-4zemA:
4.1		 2zvjA-4zemA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a01 O-GLYCOSYLTRANSFERAS
E

(Drosophila
melanogaster) 		PF13374
(TPR_10)
PF13414
(TPR_11)
PF13844
(Glyco_transf_41) 		4 SER A 428
SER A 533
GLN A 525
ASP A 459
 None
 1.40A 2zvjA-5a01A:
undetectable		 2zvjA-5a01A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Bacillus
pumilus) 		PF02011
(Glyco_hydro_48) 		4 SER A 342
TYR A 262
GLN A 323
ASP A 348
 None
 1.41A 2zvjA-5bv9A:
undetectable		 2zvjA-5bv9A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8s GUANINE-N7
METHYLTRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06471
(NSP11) 		4 SER B 220
TYR B 224
SER B 171
ASP B 234
 None
 1.39A 2zvjA-5c8sB:
undetectable		 2zvjA-5c8sB:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza C
virus) 		PF00602
(Flu_PB1) 		4 SER B 444
GLU B 492
SER B 483
ASP B 446
 None
 1.29A 2zvjA-5d9aB:
undetectable		 2zvjA-5d9aB:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl6 PUTATIVE PORIN FOR
VANILLATE
TRAFFICKING (VANP)

(Acinetobacter
baumannii) 		PF03573
(OprD) 		4 GLU A 345
TYR A 371
SER A 305
ASP A 290
 None
 1.39A 2zvjA-5dl6A:
undetectable		 2zvjA-5dl6A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ek8 LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		4 SER A 313
SER A 588
GLN A 614
ASP A 289
 None
 1.37A 2zvjA-5ek8A:
undetectable		 2zvjA-5ek8A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp1 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 SER A  91
GLU A 515
GLN A 550
ASP A 500
 None
 1.27A 2zvjA-5fp1A:
undetectable		 2zvjA-5fp1A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftz CHITIN BINDING
PROTEIN

(Streptomyces
lividans) 		PF03067
(LPMO_10) 		4 SER A 143
TYR A 128
SER A  79
ASP A  74
 None
 1.39A 2zvjA-5ftzA:
undetectable		 2zvjA-5ftzA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT CSL4

(Saccharomyces
cerevisiae) 		PF10447
(EXOSC1) 		4 GLU I 222
SER I 207
GLN I 149
ASP I 214
 None
 1.04A 2zvjA-5g06I:
undetectable		 2zvjA-5g06I:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0h HDAC6

(Danio rerio) 		PF00850
(Hist_deacetyl) 		4 SER A 548
SER A 471
GLN A 468
ASP A 449
 None
 1.38A 2zvjA-5g0hA:
undetectable		 2zvjA-5g0hA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzh RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE
1,NPH1-1,RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1

(Avena sativa;
Homo sapiens) 		PF00071
(Ras)
PF13426
(PAS_9) 		4 GLU A 305
TYR A 288
SER A 307
ASP A 270
 None
None
GTP  A 401 (-3.5A)
None
 1.38A 2zvjA-5hzhA:
undetectable		 2zvjA-5hzhA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1

(Burkholderia
thailandensis) 		PF05853
(BKACE) 		4 SER A 935
GLU A 849
SER A 609
GLN A 632
 GOL  A1202 ( 4.8A)
None
None
None
 1.33A 2zvjA-5ikzA:
2.3		 2zvjA-5ikzA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD
LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		PF04453
(OstA_C)
PF04390
(LptE) 		4 SER B 118
SER B  69
GLN A 540
ASP B 111
 None
 1.39A 2zvjA-5ivaB:
undetectable		 2zvjA-5ivaB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 TYR A 181
SER A 628
GLN A 641
ASP A 553
 EDO  A1009 (-3.5A)
None
None
EDO  A1008 (-2.7A)
 1.38A 2zvjA-5jouA:
undetectable		 2zvjA-5jouA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyu PROTEIN TRANSPORT
PROTEIN SEC24D

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 SER B 912
GLU B1007
TYR B1017
GLN B 883
 None
 1.33A 2zvjA-5kyuB:
undetectable		 2zvjA-5kyuB:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
PROTEIN TRANSLOCASE
SUBUNIT SECF

(Escherichia
coli;
Escherichia
coli) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG)
PF13721
(SecD-TM1)
PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 SER D 552
GLU D 531
SER F 240
ASP F 219
 None
 1.17A 2zvjA-5mg3D:
undetectable		 2zvjA-5mg3D:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mua RICIN B-RELATED
LECTIN

(Polyporus
squamosus) 		PF14200
(RicinB_lectin_2) 		4 SER A 188
GLU A 255
GLN A 147
ASP A 185
 None
 1.24A 2zvjA-5muaA:
undetectable		 2zvjA-5muaA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng6 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Francisella
tularensis) 		no annotation 4 SER A 322
TYR A 272
SER A  80
GLN A  77
 None
 0.91A 2zvjA-5ng6A:
undetectable		 2zvjA-5ng6A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpw GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2A

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 SER B  43
TYR B 286
SER B 259
GLN B 154
 None
 1.21A 2zvjA-5tpwB:
undetectable		 2zvjA-5tpwB:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr1 MONOCLONAL ANTIBODY,
FAB FRAGMENT, HEAVY
CHAIN
MONOCLONAL ANTIBODY,
FAB FRAGMENT, LIGHT
CHAIN

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		4 SER H  63
SER L 100
GLN L   6
ASP L   1
 None
 1.38A 2zvjA-5tr1H:
undetectable		 2zvjA-5tr1H:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		4 TYR A 272
SER A 279
GLN A 233
ASP A 418
 None
 1.08A 2zvjA-5u1sA:
undetectable		 2zvjA-5u1sA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdr RAS PROTEIN

(Choanoflagellida) 		PF00071
(Ras) 		4 SER A  89
GLU A 144
SER A 146
ASP A  85
 None
None
GNP  A 203 (-3.5A)
None
 1.39A 2zvjA-5wdrA:
undetectable		 2zvjA-5wdrA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmg UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 SER A  74
TYR A  46
SER A 253
GLN A 340
 None
 1.40A 2zvjA-5xmgA:
undetectable		 2zvjA-5xmgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyj ACETYL-COA
ACETYLTRANSFERASE

(Saccharomyces
cerevisiae) 		no annotation 4 SER B 359
GLU B 320
SER B 369
GLN B 373
 None
 1.18A 2zvjA-5xyjB:
undetectable		 2zvjA-5xyjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4g AMBP3

(Fischerella
ambigua) 		no annotation 4 GLU A 207
TYR A 168
SER A 287
ASP A 277
 None
 1.15A 2zvjA-5y4gA:
undetectable		 2zvjA-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byi BETA-MANNOSIDASE

(Xanthomonas
citri) 		no annotation 4 SER A 679
TYR A 692
SER A 394
ASP A 682
 None
 1.38A 2zvjA-6byiA:
2.2		 2zvjA-6byiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dgi D-ALANINE--D-ALANINE
LIGASE

(Vibrio cholerae) 		no annotation 4 SER A  23
GLU A  88
SER A 167
GLN A 165
 None
ACT  A 402 (-2.6A)
None
None
 1.39A 2zvjA-6dgiA:
undetectable		 2zvjA-6dgiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 4 SER B 443
GLU B 491
SER B 482
ASP B 445
 None
 1.36A 2zvjA-6evjB:
undetectable		 2zvjA-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fmq -

(-) 		no annotation 4 SER A 431
SER A 338
GLN A 337
ASP A 389
 None
None
ACT  A 707 (-4.1A)
EDO  A 701 (-3.5A)
 1.35A 2zvjA-6fmqA:
undetectable		 2zvjA-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)

(Homo sapiens) 		no annotation 4 SER A 454
GLU A 291
SER A  87
ASP A 451
 None
 1.36A 2zvjA-6gctA:
undetectable		 2zvjA-6gctA:
undetectable