SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZVA_A_1N1A513_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 428
LYS A 430
VAL A 458
ILE A 472
THR A 474
MET A 477
GLY A 480
LEU A 528
 None
 0.50A 2zvaA-1k2pA:
27.8		 2zvaA-1k2pA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
MET A 269
GLY A 272
LEU A 321
 None
 0.61A 2zvaA-1k9aA:
33.6		 2zvaA-1k9aA:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 606
MET A 629
VAL A 638
MET A 657
GLY A 660
LEU A 731
ALA A 741
 None
 0.74A 2zvaA-1lufA:
32.5		 2zvaA-1lufA:
32.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		11 LEU A 267
ALA A 288
LYS A 290
GLU A 305
MET A 309
VAL A 318
ILE A 332
THR A 334
MET A 337
LEU A 389
ALA A 399
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.76A 2zvaA-1opkA:
32.2		 2zvaA-1opkA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		11 LEU A 267
ALA A 288
LYS A 290
MET A 309
VAL A 318
ILE A 332
THR A 334
MET A 337
GLY A 340
LEU A 389
ALA A 399
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.77A 2zvaA-1opkA:
32.2		 2zvaA-1opkA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  99
LYS A 101
VAL A 131
ILE A 145
MET A 150
GLY A 153
LEU A 201
 ATP  A 535 (-3.6A)
ATP  A 535 ( 2.5A)
5EA  A1001 (-4.5A)
5EA  A1001 ( 3.7A)
None
ATP  A 535 ( 4.7A)
ATP  A 535 (-4.8A)
 0.75A 2zvaA-1s9iA:
17.0		 2zvaA-1s9iA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  78
ALA A  99
VAL A 131
ILE A 145
MET A 150
GLY A 153
LEU A 201
 ATP  A 535 (-3.9A)
ATP  A 535 (-3.6A)
5EA  A1001 (-4.5A)
5EA  A1001 ( 3.7A)
None
ATP  A 535 ( 4.7A)
ATP  A 535 (-4.8A)
 0.57A 2zvaA-1s9iA:
17.0		 2zvaA-1s9iA:
23.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 389
LYS A 391
MET A 410
VAL A 419
MET A 438
GLY A 441
LEU A 489
 None
 0.69A 2zvaA-1snxA:
21.9		 2zvaA-1snxA:
41.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 595
ALA A 621
LYS A 623
GLU A 640
VAL A 654
THR A 670
GLY A 676
LEU A 799
 STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
 0.85A 2zvaA-1t46A:
24.8		 2zvaA-1t46A:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		12 LEU X  17
ALA X  37
LYS X  39
GLU X  54
MET X  58
VAL X  67
ILE X  80
THR X  82
MET X  85
GLY X  88
LEU X 137
ALA X 147
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
None
STU  X 902 (-4.1A)
None
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.68A 2zvaA-2dq7X:
38.0		 2zvaA-2dq7X:
67.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 162
ALA A 184
LYS A 186
GLU A 201
VAL A 220
ILE A 234
ALA A 319
 None
 0.79A 2zvaA-2eu9A:
24.5		 2zvaA-2eu9A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 LEU A  19
ALA A  40
LYS A  42
GLU A  59
ILE A  91
MET A  96
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
None
None
ADP  A 500 (-4.3A)
 0.69A 2zvaA-2f9gA:
16.0		 2zvaA-2f9gA:
23.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
MET A 341
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.62A 2zvaA-2h8hA:
33.9		 2zvaA-2h8hA:
34.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
MET A 341
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.81A 2zvaA-2hckA:
33.8		 2zvaA-2hckA:
60.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 ALA A 659
GLU A 678
MET A 682
ILE A 705
THR A 707
MET A 710
GLY A 713
LEU A 761
 ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.67A 2zvaA-2henA:
26.4		 2zvaA-2henA:
40.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 ALA A 659
LYS A 661
GLU A 678
MET A 682
ILE A 705
THR A 707
MET A 710
LEU A 761
 ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.7A)
 0.67A 2zvaA-2henA:
26.4		 2zvaA-2henA:
40.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		12 LEU A 251
ALA A 271
LYS A 273
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
MET A 319
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.41A 2zvaA-2hk5A:
31.0		 2zvaA-2hk5A:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		12 LEU A 248
ALA A 269
LYS A 271
GLU A 286
MET A 290
VAL A 299
ILE A 313
THR A 315
MET A 318
GLY A 321
LEU A 370
ALA A 380
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
None
None
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.83A 2zvaA-2hz0A:
34.2		 2zvaA-2hz0A:
46.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
ILE A 497
LEU A 553
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-4.4A)
 0.64A 2zvaA-2j0jA:
32.6		 2zvaA-2j0jA:
17.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		8 ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
ILE A 497
GLY A 505
LEU A 553
 BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
None
None
None
None
BII  A1687 (-3.6A)
BII  A1687 (-4.2A)
 0.64A 2zvaA-2jkmA:
32.6		 2zvaA-2jkmA:
40.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		12 LEU A 251
ALA A 271
LYS A 273
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
MET A 319
GLY A 322
LEU A 371
ALA A 381
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
 0.87A 2zvaA-2og8A:
35.7		 2zvaA-2og8A:
73.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 588
ALA A 614
LYS A 616
GLU A 633
MET A 637
VAL A 647
THR A 663
GLY A 669
LEU A 785
 None
 0.92A 2zvaA-2ogvA:
30.2		 2zvaA-2ogvA:
38.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 ALA A  34
LYS A  36
GLU A  53
MET A  57
VAL A  66
MET A  85
LEU A 140
 AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
AGS  A3001 ( 4.8A)
None
None
None
None
 0.66A 2zvaA-2pmiA:
23.5		 2zvaA-2pmiA:
28.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
ALA A 515
GLU A 534
MET A 538
GLY A 570
LEU A 633
ALA A 643
 None
 0.73A 2zvaA-2psqA:
34.1		 2zvaA-2psqA:
31.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 215
LYS A 217
GLU A 230
THR A 265
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.52A 2zvaA-2qluA:
27.0		 2zvaA-2qluA:
24.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 651
LYS A 653
GLU A 670
MET A 674
ILE A 697
THR A 699
MET A 702
GLY A 705
LEU A 753
 PTR  A 701 ( 4.7A)
None
None
None
None
None
PTR  A 701 ( 3.5A)
None
None
 0.75A 2zvaA-2qobA:
34.4		 2zvaA-2qobA:
37.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ALA A 705
GLU A 724
MET A 728
ILE A 751
THR A 753
MET A 756
GLY A 759
LEU A 807
 None
 0.44A 2zvaA-2r2pA:
34.9		 2zvaA-2r2pA:
41.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ALA A 705
LYS A 707
GLU A 724
MET A 728
ILE A 751
MET A 756
GLY A 759
LEU A 807
 None
 0.67A 2zvaA-2r2pA:
34.9		 2zvaA-2r2pA:
41.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 724
ALA A 749
LYS A 751
VAL A 781
THR A 796
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 ( 4.7A)
GW7  A   1 (-4.0A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.91A 2zvaA-2r4bA:
24.7		 2zvaA-2r4bA:
34.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A 103
LYS A 105
GLU A 124
VAL A 137
MET A 156
GLY A 159
LEU A 205
ALA A 215
 ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
ANP  A1480 (-4.7A)
None
None
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
 0.93A 2zvaA-2v55A:
21.2		 2zvaA-2v55A:
23.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 ALA A 651
LYS A 653
MET A 674
ILE A 697
THR A 699
MET A 702
GLY A 705
LEU A 753
 Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.9A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-3.5A)
None
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
 0.68A 2zvaA-2xyuA:
27.2		 2zvaA-2xyuA:
41.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A1028
LYS A1030
GLU A1047
MET A1051
VAL A1060
MET A1079
GLY A1082
 S91  A   1 (-3.2A)
S91  A   1 ( 4.2A)
None
None
None
None
S91  A   1 (-3.3A)
 0.69A 2zvaA-2z8cA:
31.9		 2zvaA-2z8cA:
35.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1002
ALA A1028
GLU A1047
MET A1051
VAL A1060
MET A1079
GLY A1082
 S91  A   1 ( 4.1A)
S91  A   1 (-3.2A)
None
None
None
None
S91  A   1 (-3.3A)
 0.55A 2zvaA-2z8cA:
31.9		 2zvaA-2z8cA:
35.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		12 LEU A 253
ALA A 273
LYS A 275
GLU A 290
MET A 294
VAL A 303
ILE A 317
THR A 319
MET A 322
GLY A 325
LEU A 374
ALA A 384
 None
 0.46A 2zvaA-2zv7A:
42.5		 2zvaA-2zv7A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 515
LYS A 517
GLU A 534
MET A 538
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.66A 2zvaA-3b2tA:
26.8		 2zvaA-3b2tA:
37.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
ALA A 515
GLU A 534
MET A 538
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.65A 2zvaA-3b2tA:
26.8		 2zvaA-3b2tA:
37.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
MET A 269
GLY A 272
LEU A 321
 None
 0.61A 2zvaA-3d7uA:
28.4		 2zvaA-3d7uA:
43.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		9 ALA A 663
LYS A 665
GLU A 682
MET A 686
VAL A 695
ILE A 709
MET A 714
GLY A 717
LEU A 765
 IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.68A 2zvaA-3dkoA:
32.1		 2zvaA-3dkoA:
38.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 696
LYS A 723
VAL A 753
THR A 768
GLY A 774
LEU A 822
ALA A 832
 ANP  A   1 (-4.4A)
ANP  A   1 (-3.4A)
None
ANP  A   1 ( 4.8A)
ANP  A   1 ( 4.9A)
ANP  A   1 (-4.7A)
None
 0.69A 2zvaA-3kexA:
27.9		 2zvaA-3kexA:
32.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ALA A 665
LYS A 667
MET A 688
ILE A 711
THR A 713
MET A 716
GLY A 719
LEU A 767
 None
None
None
None
None
None
GOL  A 403 (-3.4A)
None
 0.61A 2zvaA-3kulA:
34.7		 2zvaA-3kulA:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 ALA A  49
LYS A  51
GLU A  69
VAL A  82
MET A 101
LEU A 151
ALA A 161
 ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
None
None
ADP  A 314 (-4.6A)
None
 0.56A 2zvaA-3nizA:
26.8		 2zvaA-3nizA:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 192
ALA A 213
LYS A 215
GLU A 234
VAL A 247
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
None
AMP  A 577 (-4.8A)
 0.55A 2zvaA-3nyoA:
19.0		 2zvaA-3nyoA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 ALA A  38
LYS A  40
GLU A  58
VAL A  72
MET A  93
LEU A 141
ALA A 151
 None
 0.77A 2zvaA-3oz6A:
22.6		 2zvaA-3oz6A:
25.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 ALA A 576
LYS A 578
GLU A 596
MET A 600
VAL A 609
ILE A 623
THR A 625
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
None
STU  A   1 (-4.1A)
 0.80A 2zvaA-3ppzA:
32.5		 2zvaA-3ppzA:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 ALA A 576
LYS A 578
MET A 600
VAL A 609
ILE A 623
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.60A 2zvaA-3ppzA:
32.5		 2zvaA-3ppzA:
31.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 217
LYS A 219
GLU A 232
THR A 267
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.59A 2zvaA-3q4tA:
26.7		 2zvaA-3q4tA:
26.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 345
LYS A 368
GLU A 384
THR A 413
GLY A 419
LEU A 467
ALA A 477
 STU  A   1 (-3.8A)
STU  A   1 (-3.1A)
STU  A   1 (-3.7A)
STU  A   1 (-3.9A)
STU  A   1 (-3.6A)
STU  A   1 (-4.6A)
STU  A   1 ( 4.1A)
 0.78A 2zvaA-3s95A:
27.5		 2zvaA-3s95A:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LYS A 368
GLU A 384
MET A 388
THR A 413
GLY A 419
LEU A 467
ALA A 477
 STU  A   1 (-3.1A)
STU  A   1 (-3.7A)
None
STU  A   1 (-3.9A)
STU  A   1 (-3.6A)
STU  A   1 (-4.6A)
STU  A   1 ( 4.1A)
 0.69A 2zvaA-3s95A:
27.5		 2zvaA-3s95A:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 443
LYS A 445
VAL A 473
ILE A 487
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.73A 2zvaA-3sxsA:
34.3		 2zvaA-3sxsA:
43.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 423
ALA A 443
MET A 464
VAL A 473
ILE A 487
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.53A 2zvaA-3sxsA:
34.3		 2zvaA-3sxsA:
43.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  75
ALA A  96
LYS A  98
VAL A 128
ILE A 142
MET A 147
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.66A 2zvaA-3wigA:
23.7		 2zvaA-3wigA:
25.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A1951
ALA A1978
LYS A1980
MET A2001
ILE A2024
MET A2029
GLY A2032
LEU A2086
 VGH  A3000 ( 4.4A)
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
None
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
 0.50A 2zvaA-3zbfA:
26.3		 2zvaA-3zbfA:
38.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 649
LYS A 651
GLU A 668
MET A 672
ILE A 695
THR A 697
MET A 700
GLY A 703
LEU A 751
 None
 0.55A 2zvaA-3zfxA:
35.5		 2zvaA-3zfxA:
39.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 121
LYS A 123
GLU A 140
MET A 144
ILE A 167
THR A 169
MET A 172
GLY A 175
LEU A 223
 30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
None
30K  A1365 (-3.8A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.51A 2zvaA-4aw5A:
34.0		 2zvaA-4aw5A:
39.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  42
ALA A  63
GLU A  81
VAL A  94
ILE A 108
GLY A 116
LEU A 164
ALA A 174
 XZN  A1317 (-3.6A)
XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.4A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 0.87A 2zvaA-4bc6A:
23.8		 2zvaA-4bc6A:
25.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 653
MET A 676
THR A 701
MET A 704
GLY A 707
LEU A 773
ALA A 783
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
None
None
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
 0.73A 2zvaA-4ckrA:
29.7		 2zvaA-4ckrA:
33.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
ALA A 653
LYS A 655
GLU A 672
MET A 676
THR A 701
ALA A 783
 None
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.7A)
 0.79A 2zvaA-4ckrA:
29.7		 2zvaA-4ckrA:
33.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
ALA A 653
LYS A 655
MET A 676
THR A 701
MET A 704
ALA A 783
 None
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
None
DI1  A1000 (-3.7A)
 0.81A 2zvaA-4ckrA:
29.7		 2zvaA-4ckrA:
33.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 663
ALA A 684
LYS A 686
GLU A 705
VAL A 721
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.81A 2zvaA-4crsA:
18.6		 2zvaA-4crsA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 663
ALA A 684
LYS A 686
VAL A 721
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.81A 2zvaA-4crsA:
18.6		 2zvaA-4crsA:
24.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 ALA A 588
LYS A 590
GLU A 607
VAL A 620
ILE A 634
GLY A 642
LEU A 690
 GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
None
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.63A 2zvaA-4e93A:
35.9		 2zvaA-4e93A:
32.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 377
ALA A 400
LYS A 402
GLU A 420
MET A 424
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.41A 2zvaA-4f4pA:
33.1		 2zvaA-4f4pA:
36.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A1122
ALA A1148
GLU A1167
VAL A1180
ILE A1194
MET A1199
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.9A)
None
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.64A 2zvaA-4fodA:
24.9		 2zvaA-4fodA:
35.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 855
ALA A 880
LYS A 882
GLU A 898
VAL A 911
GLY A 935
LEU A 983
 IZA  A2001 (-3.7A)
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
None
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
 0.73A 2zvaA-4gl9A:
29.9		 2zvaA-4gl9A:
36.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 828
ALA A 853
LYS A 855
GLU A 871
VAL A 884
GLY A 908
LEU A 956
ALA A 966
 19S  A1201 (-3.9A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.86A 2zvaA-4hviA:
31.3		 2zvaA-4hviA:
32.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
MET A 341
GLY A 344
LEU A 393
ALA A 403
 0J9  A 601 (-4.0A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 (-4.4A)
None
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
0J9  A 601 (-3.5A)
 0.61A 2zvaA-4k11A:
33.2		 2zvaA-4k11A:
52.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 478
ALA A 506
LYS A 508
GLU A 525
MET A 529
GLY A 561
LEU A 624
ALA A 634
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
ACP  A 801 ( 4.6A)
ACP  A 801 (-4.4A)
None
 0.69A 2zvaA-4k33A:
27.9		 2zvaA-4k33A:
36.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  33
ALA A  54
LYS A  56
GLU A  70
MET A  74
VAL A  83
GLY A 105
LEU A 153
ALA A 163
 GOL  A 404 ( 3.6A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
None
None
GOL  A 403 (-4.1A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
GOL  A 403 ( 3.0A)
 0.81A 2zvaA-4lg4A:
19.2		 2zvaA-4lg4A:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  33
ALA A  54
LYS A  56
MET A  74
VAL A  83
ILE A  97
GLY A 105
LEU A 153
ALA A 163
 GOL  A 404 ( 3.6A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
None
GOL  A 403 (-4.1A)
None
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
GOL  A 403 ( 3.0A)
 0.70A 2zvaA-4lg4A:
19.2		 2zvaA-4lg4A:
27.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		11 LEU A 273
ALA A 293
LYS A 295
GLU A 310
MET A 314
VAL A 323
ILE A 336
MET A 341
GLY A 344
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.56A 2zvaA-4lggA:
33.2		 2zvaA-4lggA:
65.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		7 ALA A 218
LYS A 220
GLU A 239
VAL A 255
MET A 274
GLY A 277
LEU A 324
 29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 (-4.8A)
None
None
29X  A 702 (-4.6A)
 0.82A 2zvaA-4mk0A:
15.6		 2zvaA-4mk0A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A  67
LYS A  69
GLU A  85
MET A  89
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.7A)
None
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.94A 2zvaA-4o38A:
21.8		 2zvaA-4o38A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  46
ALA A  67
LYS A  69
GLU A  85
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.74A 2zvaA-4o38A:
21.8		 2zvaA-4o38A:
26.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ALA A 644
GLU A 663
MET A 667
ILE A 690
THR A 692
MET A 695
GLY A 698
LEU A 746
 None
 0.89A 2zvaA-4p2kA:
36.0		 2zvaA-4p2kA:
40.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		12 LEU A  14
ALA A  35
LYS A  37
GLU A  52
MET A  56
VAL A  65
ILE A  79
THR A  81
MET A  84
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
None
None
None
ACP  A1264 (-4.5A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.48A 2zvaA-4ueuA:
37.8		 2zvaA-4ueuA:
57.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  40
ALA A  61
VAL A  92
ILE A 106
GLY A 114
LEU A 162
ALA A 172
 6UI  A 700 ( 4.9A)
6UI  A 700 (-3.3A)
None
6UI  A 700 (-3.5A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
 0.72A 2zvaA-4usfA:
19.2		 2zvaA-4usfA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 193
ALA A 214
LYS A 216
GLU A 235
VAL A 248
MET A 267
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
None
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.79A 2zvaA-4wboA:
25.8		 2zvaA-4wboA:
18.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 11 LEU B 267
ALA B 288
LYS B 290
MET B 309
VAL B 318
ILE B 332
THR B 334
MET B 337
GLY B 340
LEU B 389
ALA B 399
 1N1  B 601 (-3.7A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 (-3.7A)
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
1N1  B 601 (-3.3A)
None
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
 0.58A 2zvaA-4xeyB:
33.3		 2zvaA-4xeyB:
34.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 408
ALA A 428
VAL A 458
ILE A 472
THR A 474
MET A 477
GLY A 480
LEU A 528
 None
 0.67A 2zvaA-4xi2A:
25.2		 2zvaA-4xi2A:
27.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
ALA A 642
LYS A 644
GLU A 661
VAL A 675
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.75A 2zvaA-4xufA:
31.3		 2zvaA-4xufA:
38.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		9 LEU A 408
ALA A 428
LYS A 430
VAL A 458
ILE A 472
THR A 474
MET A 477
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
None
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.50A 2zvaA-4y93A:
32.8		 2zvaA-4y93A:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 193
ALA A 214
LYS A 216
GLU A 235
VAL A 248
MET A 267
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
None
None
 0.81A 2zvaA-4yhjA:
22.9		 2zvaA-4yhjA:
20.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
ALA A 512
LYS A 514
GLU A 531
MET A 535
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.77A 2zvaA-5a46A:
31.4		 2zvaA-5a46A:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 599
ALA A 625
LYS A 627
GLU A 644
MET A 648
VAL A 658
ILE A 672
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.89A 2zvaA-5grnA:
25.8		 2zvaA-5grnA:
37.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  43
LYS A  45
GLU A  61
MET A  65
VAL A  74
ILE A  88
ALA A 153
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
None
6G2  A 901 ( 4.2A)
 0.73A 2zvaA-5j5tA:
23.9		 2zvaA-5j5tA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A  43
LYS A  45
MET A  65
VAL A  74
ILE A  88
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.69A 2zvaA-5j5tA:
23.9		 2zvaA-5j5tA:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 718
ALA A 743
LYS A 745
GLU A 762
MET A 766
MET A 793
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.50A 2zvaA-5j9zA:
32.5		 2zvaA-5j9zA:
33.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 209
ALA A 228
LYS A 230
GLU A 250
MET A 254
ILE A 281
GLY A 289
LEU A 338
 None
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
None
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
 0.81A 2zvaA-5ko1A:
28.1		 2zvaA-5ko1A:
28.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 ALA A 909
LYS A 911
GLU A 927
VAL A 940
MET A 959
GLY A 962
LEU A1016
 ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
None
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
 0.62A 2zvaA-5lpyA:
25.9		 2zvaA-5lpyA:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 ALA A 909
LYS A 911
GLU A 927
VAL A 940
MET A 959
GLY A 962
LEU A1016
 ADP  A1200 (-3.5A)
ADP  A1200 ( 4.3A)
None
None
None
ADP  A1200 ( 4.0A)
ADP  A1200 (-4.7A)
 0.62A 2zvaA-5lpzA:
25.7		 2zvaA-5lpzA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  98
ALA A 119
LYS A 121
GLU A 136
VAL A 157
GLY A 181
LEU A 232
ALA A 540
 W4A  A 716 (-4.1A)
W4A  A 716 ( 3.9A)
SO4  A 702 (-3.3A)
DMS  A 717 (-4.0A)
DMS  A 717 (-4.3A)
W4A  A 716 (-3.8A)
None
DMS  A 717 ( 4.5A)
 1.03A 2zvaA-5myvA:
22.5		 2zvaA-5myvA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A 119
LYS A 121
GLU A 140
VAL A 153
MET A 172
GLY A 175
LEU A 221
ALA A 231
 None
 0.69A 2zvaA-5u7qA:
22.2		 2zvaA-5u7qA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 ALA A 218
LYS A 220
GLU A 239
VAL A 255
MET A 274
GLY A 277
LEU A 324
 QRW  A 601 (-3.4A)
QRW  A 601 (-3.0A)
QRW  A 601 (-3.9A)
None
MES  A 604 (-3.9A)
None
None
 0.81A 2zvaA-5uuuA:
24.8		 2zvaA-5uuuA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 8 ALA A  45
LYS A  47
ILE A  93
THR A  95
MET A  98
GLY A 101
LEU A 153
ALA A 163
 9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.81A 2zvaA-5w5jA:
23.8		 2zvaA-5w5jA:
28.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 8 LEU A  24
ALA A  45
ILE A  93
THR A  95
MET A  98
GLY A 101
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.78A 2zvaA-5w5jA:
23.8		 2zvaA-5w5jA:
28.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 8 LEU A  86
ALA A 107
LYS A 109
GLU A 124
VAL A 145
GLY A 169
LEU A 220
ALA A 496
 EMH  A 705 (-3.9A)
EMH  A 705 (-3.6A)
EMH  A 705 ( 4.8A)
None
EMH  A 705 ( 4.9A)
EMH  A 705 (-3.5A)
None
EMH  A 705 ( 4.0A)
 1.00A 2zvaA-5xv7A:
23.8		 2zvaA-5xv7A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 7 ALA A  54
LYS A  56
VAL A  83
ILE A  97
GLY A 105
LEU A 153
ALA A 163
 ANP  A 501 ( 3.7A)
ANP  A 501 (-2.4A)
None
None
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
None
 0.79A 2zvaA-6ao5A:
23.3		 2zvaA-6ao5A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 7 LEU A  33
ALA A  54
VAL A  83
ILE A  97
GLY A 105
LEU A 153
ALA A 163
 ANP  A 501 ( 3.8A)
ANP  A 501 ( 3.7A)
None
None
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
None
 0.51A 2zvaA-6ao5A:
23.3		 2zvaA-6ao5A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 LEU A 881
ALA A 906
LYS A 908
GLU A 925
VAL A 938
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.64A 2zvaA-6c7yA:
30.8		 2zvaA-6c7yA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 8 LEU A 197
ALA A 217
LYS A 219
ILE A 262
THR A 264
MET A 267
GLY A 270
LEU A 319
 FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
None
None
FKY  A9001 (-3.0A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 1.16A 2zvaA-6cz4A:
15.9		 2zvaA-6cz4A:
12.86