SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZUL_A_SAMA376_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b55 | TYROSINE-PROTEINKINASE BTK (Homo sapiens) |
PF00169(PH)PF00779(BTK) | 3 | SER A 21GLU A 108ASP A 57 | 4IP A 171 (-2.5A)NoneNone | 0.81A | 2zulA-1b55A:undetectable | 2zulA-1b55A:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1buy | PROTEIN(ERYTHROPOIETIN) (Homo sapiens) |
PF00758(EPO_TPO) | 3 | SER A 120GLU A 62ASP A 43 | None | 0.60A | 2zulA-1buyA:undetectable | 2zulA-1buyA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cja | PROTEIN(ACTIN-FRAGMINKINASE) (Physarumpolycephalum) |
PF09192(Act-Frag_cataly) | 3 | SER A 233GLU A 163ASP A 60 | None | 0.70A | 2zulA-1cjaA:undetectable | 2zulA-1cjaA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ez4 | LACTATEDEHYDROGENASE (Lactobacilluspentosus) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 3 | SER A 317GLU A 230ASP A 223 | None | 0.80A | 2zulA-1ez4A:7.0 | 2zulA-1ez4A:23.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iyx | ENOLASE (Enterococcushirae) |
PF00113(Enolase_C)PF03952(Enolase_N) | 3 | SER A 369GLU A 246ASP A 291 | SO4 A1002 (-3.1A)NoneNone | 0.81A | 2zulA-1iyxA:undetectable | 2zulA-1iyxA:24.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n10 | POLLEN ALLERGEN PHLP 1 (Phleum pratense) |
PF01357(Pollen_allerg_1)PF03330(DPBB_1) | 3 | SER A1085GLU A1075ASP A1017 | None | 0.64A | 2zulA-1n10A:undetectable | 2zulA-1n10A:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1omo | ALANINEDEHYDROGENASE (Archaeoglobusfulgidus) |
PF02423(OCD_Mu_crystall) | 3 | SER A 186GLU A 249ASP A 219 | SER A 186 ( 0.0A)GLU A 249 (-0.6A)ASP A 219 (-0.5A) | 0.65A | 2zulA-1omoA:5.0 | 2zulA-1omoA:24.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p8r | ARGINASE 1 (Rattusnorvegicus) |
PF00491(Arginase) | 3 | SER A 137GLU A 277ASP A 274 | S2C A 551 (-3.3A)S2C A 551 (-3.6A)None | 0.75A | 2zulA-1p8rA:3.2 | 2zulA-1p8rA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1psz | PROTEIN (SURFACEANTIGEN PSAA) (Streptococcuspneumoniae) |
PF01297(ZnuA) | 3 | SER A 212GLU A 254ASP A 65 | None | 0.78A | 2zulA-1pszA:undetectable | 2zulA-1pszA:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qu2 | ISOLEUCYL-TRNASYNTHETASE (Staphylococcusaureus) |
PF00133(tRNA-synt_1)PF06827(zf-FPG_IleRS)PF08264(Anticodon_1) | 3 | SER A 856GLU A 887ASP A 2 | None | 0.65A | 2zulA-1qu2A:undetectable | 2zulA-1qu2A:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sxj | ACTIVATOR 1 41 KDASUBUNITACTIVATOR 1 40 KDASUBUNIT (Saccharomycescerevisiae;Saccharomycescerevisiae) |
PF00004(AAA)PF08542(Rep_fac_C)PF13177(DNA_pol3_delta2) | 3 | SER E 183GLU D 141ASP D 99 | None MG D 814 (-3.4A)None | 0.74A | 2zulA-1sxjE:2.5 | 2zulA-1sxjE:23.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tlf | LAC REPRESSOR (Escherichiacoli) |
PF13377(Peripla_BP_3) | 3 | SER A 85GLU A 277ASP A 247 | None | 0.58A | 2zulA-1tlfA:4.7 | 2zulA-1tlfA:22.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v9x | POLY (ADP-RIBOSE)POLYMERASE (Arabidopsisthaliana) |
PF00645(zf-PARP) | 3 | SER A 3GLU A 73ASP A 71 | None | 0.73A | 2zulA-1v9xA:undetectable | 2zulA-1v9xA:11.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vho | ENDOGLUCANASE (Thermotogamaritima) |
PF05343(Peptidase_M42) | 3 | SER A 174GLU A 274ASP A 236 | SER A 174 ( 0.0A)GLU A 274 ( 0.6A)ASP A 236 ( 0.6A) | 0.80A | 2zulA-1vhoA:undetectable | 2zulA-1vhoA:24.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vlp | NICOTINATEPHOSPHORIBOSYLTRANSFERASE (Saccharomycescerevisiae) |
PF04095(NAPRTase) | 3 | SER A 102GLU A 382ASP A 401 | None | 0.76A | 2zulA-1vlpA:undetectable | 2zulA-1vlpA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y12 | HYPOTHETICAL PROTEINPA0085 (Pseudomonasaeruginosa) |
PF05638(T6SS_HCP) | 3 | SER A 16GLU A 96ASP A 135 | None | 0.66A | 2zulA-1y12A:undetectable | 2zulA-1y12A:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zef | ALKALINE PHOSPHATASE (Homo sapiens) |
PF00245(Alk_phosphatase) | 3 | SER A 287GLU A 339ASP A 72 | None | 0.81A | 2zulA-1zefA:2.1 | 2zulA-1zefA:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d5l | DIPEPTIDYLAMINOPEPTIDASE IV,PUTATIVE (Porphyromonasgingivalis) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 3 | SER A 290GLU A 329ASP A 358 | None | 0.80A | 2zulA-2d5lA:undetectable | 2zulA-2d5lA:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ecz | SORBIN AND SH3DOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF00018(SH3_1) | 3 | SER A 3GLU A 44ASP A 39 | None | 0.81A | 2zulA-2eczA:undetectable | 2zulA-2eczA:9.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fbo | VARIABLEREGION-CONTAININGCHITIN-BINDINGPROTEIN 3 (Branchiostomafloridae) |
PF07686(V-set) | 3 | SER J 202GLU J 119ASP J 123 | None | 0.83A | 2zulA-2fboJ:undetectable | 2zulA-2fboJ:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hqy | CONSERVEDHYPOTHETICAL PROTEIN (Bacteroidesthetaiotaomicron) |
PF09924(DUF2156) | 3 | SER A 36GLU A 268ASP A 117 | None | 0.81A | 2zulA-2hqyA:undetectable | 2zulA-2hqyA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iiz | MELANIN BIOSYNTHESISPROTEIN TYRA,PUTATIVE (Shewanellaoneidensis) |
PF04261(Dyp_perox) | 3 | SER A 237GLU A 213ASP A 218 | NoneHEM A 400 ( 4.7A)None | 0.82A | 2zulA-2iizA:undetectable | 2zulA-2iizA:23.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j3m | PROLYL-TRNASYNTHETASE (Enterococcusfaecalis) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF04073(tRNA_edit) | 3 | SER A 147GLU A 407ASP A 198 | None MN A1567 (-2.5A)None | 0.83A | 2zulA-2j3mA:undetectable | 2zulA-2j3mA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kmw | UNCHARACTERIZEDPROTEIN AT3G03773 (Arabidopsisthaliana) |
PF04969(CS) | 3 | SER A 119GLU A 112ASP A 108 | None | 0.82A | 2zulA-2kmwA:undetectable | 2zulA-2kmwA:16.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2paf | LACTOSE OPERONREPRESSOR (Escherichiacoli) |
PF13377(Peripla_BP_3) | 3 | SER A 85GLU A 277ASP A 247 | None | 0.68A | 2zulA-2pafA:4.5 | 2zulA-2pafA:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ptz | ENOLASE (Trypanosomabrucei) |
PF00113(Enolase_C)PF03952(Enolase_N) | 3 | SER A 37GLU A 248ASP A 295 | None | 0.83A | 2zulA-2ptzA:undetectable | 2zulA-2ptzA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uxt | PROTEIN SUFI (Escherichiacoli) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 3 | SER A 313GLU A 392ASP A 361 | None | 0.72A | 2zulA-2uxtA:undetectable | 2zulA-2uxtA:23.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vwk | DNA POLYMERASE (Thermococcusgorgonarius) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 3 | SER A 492GLU A 330ASP A 259 | None | 0.55A | 2zulA-2vwkA:undetectable | 2zulA-2vwkA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y6g | XYLANASE (Rhodothermusmarinus) |
PF02018(CBM_4_9) | 3 | SER A 48GLU A 95ASP A 97 | None | 0.79A | 2zulA-2y6gA:undetectable | 2zulA-2y6gA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yf0 | MYOTUBULARIN-RELATEDPROTEIN 6 (Homo sapiens) |
PF06602(Myotub-related) | 3 | SER A 344GLU A 369ASP A 129 | None | 0.75A | 2zulA-2yf0A:undetectable | 2zulA-2yf0A:21.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zwv | PROBABLE RIBOSOMALRNA SMALL SUBUNITMETHYLTRANSFERASE (Thermusthermophilus) |
PF05175(MTS) | 3 | SER A 216GLU A 262ASP A 288 | SAH A 376 (-2.5A)SAH A 376 (-2.7A)SAH A 376 (-4.1A) | 0.06A | 2zulA-2zwvA:64.1 | 2zulA-2zwvA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a2f | DNA POLYMERASE (Pyrococcusfuriosus) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 3 | SER A 493GLU A 330ASP A 259 | None | 0.71A | 2zulA-3a2fA:undetectable | 2zulA-3a2fA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b9t | TWIN-ARGININETRANSLOCATIONPATHWAY SIGNALPROTEIN (Methylobacillusflagellatus) |
PF03069(FmdA_AmdA) | 3 | SER A 305GLU A 350ASP A 348 | NoneEDO A 494 (-3.5A)EDO A 495 (-4.1A) | 0.77A | 2zulA-3b9tA:undetectable | 2zulA-3b9tA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dwf | 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 (Cavia porcellus) |
PF00106(adh_short) | 3 | SER A 67GLU A 221ASP A 219 | NAP A 301 (-4.9A)SO4 A 1 (-4.6A)None | 0.83A | 2zulA-3dwfA:4.0 | 2zulA-3dwfA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e4f | AMINOGLYCOSIDEN3-ACETYLTRANSFERASE (Bacillusanthracis) |
PF02522(Antibiotic_NAT) | 3 | SER A 157GLU A 186ASP A 220 | None | 0.81A | 2zulA-3e4fA:undetectable | 2zulA-3e4fA:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egi | TRIMETHYLGUANOSINESYNTHASE HOMOLOG (Homo sapiens) |
PF09445(Methyltransf_15) | 3 | SER A 688GLU A 827ASP A 660 | None | 0.65A | 2zulA-3egiA:11.8 | 2zulA-3egiA:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fgb | UNCHARACTERIZEDPROTEIN Q89ZH8_BACTN (Bacteroidesthetaiotaomicron) |
PF10282(Lactonase) | 3 | SER A 75GLU A 252ASP A 276 | None | 0.83A | 2zulA-3fgbA:undetectable | 2zulA-3fgbA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fh3 | PUTATIVE ECF-TYPESIGMA FACTORNEGATIVE EFFECTOR (Bacillusanthracis) |
PF12207(DUF3600) | 3 | SER A 130GLU A 151ASP A 158 | None | 0.71A | 2zulA-3fh3A:undetectable | 2zulA-3fh3A:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hh8 | METAL ABCTRANSPORTERSUBSTRATE-BINDINGLIPOPROTEIN (Streptococcuspyogenes) |
PF01297(ZnuA) | 3 | SER A 212GLU A 254ASP A 65 | None | 0.74A | 2zulA-3hh8A:undetectable | 2zulA-3hh8A:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i2t | EPIDERMAL GROWTHFACTOR RECEPTOR,ISOFORM A (Drosophilamelanogaster) |
PF00757(Furin-like)PF01030(Recep_L_domain)PF14843(GF_recep_IV) | 3 | SER A 141GLU A 57ASP A 34 | None | 0.78A | 2zulA-3i2tA:undetectable | 2zulA-3i2tA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | PRE-MRNA-SPLICINGFACTOR CWF10 (Schizosaccharomycespombe) |
PF00009(GTP_EFTU)PF00679(EFG_C)PF03144(GTP_EFTU_D2)PF03764(EFG_IV)PF16004(EFTUD2) | 3 | SER B 363GLU B 387ASP B 285 | None | 0.64A | 2zulA-3jb9B:undetectable | 2zulA-3jb9B:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lk7 | UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATELIGASE (Streptococcusagalactiae) |
PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 3 | SER A 383GLU A 45ASP A 39 | None | 0.83A | 2zulA-3lk7A:4.6 | 2zulA-3lk7A:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n8u | IMELYSIN PEPTIDASE (Bacteroidesovatus) |
PF09375(Peptidase_M75) | 3 | SER A 308GLU A 137ASP A 119 | None MG A 1 ( 4.6A)None | 0.79A | 2zulA-3n8uA:undetectable | 2zulA-3n8uA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nqh | GLYCOSYL HYDROLASE (Bacteroidesthetaiotaomicron) |
PF04616(Glyco_hydro_43) | 3 | SER A 223GLU A 105ASP A 126 | NoneGOL A 501 (-2.8A)None | 0.62A | 2zulA-3nqhA:undetectable | 2zulA-3nqhA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ph9 | ANTERIOR GRADIENTPROTEIN 3 HOMOLOG (Homo sapiens) |
PF13899(Thioredoxin_7) | 3 | SER A 74GLU A 103ASP A 106 | None | 0.55A | 2zulA-3ph9A:undetectable | 2zulA-3ph9A:15.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3poc | ALPHA-GLUCOSIDASE (Blautia obeum) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 3 | SER A 423GLU A 487ASP A 176 | None | 0.57A | 2zulA-3pocA:undetectable | 2zulA-3pocA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pqd | L-LACTATEDEHYDROGENASE (Bacillussubtilis) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 3 | SER A 239GLU A 182ASP A 216 | None | 0.70A | 2zulA-3pqdA:6.5 | 2zulA-3pqdA:24.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3quc | INORGANICPYROPHOSPHATASE (Bacteroidesthetaiotaomicron) |
PF13419(HAD_2) | 3 | SER A 53GLU A 178ASP A 202 | None | 0.81A | 2zulA-3qucA:3.3 | 2zulA-3qucA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sim | PROTEIN, FAMILY 18CHITINASE (Crocus vernus) |
PF00704(Glyco_hydro_18) | 3 | SER A 34GLU A 266ASP A 262 | None | 0.59A | 2zulA-3simA:undetectable | 2zulA-3simA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ujg | SERINE/THREONINE-PROTEIN KINASE SRK2E (Arabidopsisthaliana) |
PF00069(Pkinase) | 3 | SER A 29GLU A 65ASP A 59 | None | 0.69A | 2zulA-3ujgA:undetectable | 2zulA-3ujgA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v4h | HYPOTHETICAL PROTEIN (Yersinia pestis) |
PF05638(T6SS_HCP) | 3 | SER A 16GLU A 95ASP A 135 | None | 0.75A | 2zulA-3v4hA:undetectable | 2zulA-3v4hA:16.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w08 | ALDOXIME DEHYDRATASE (Pseudomonaschlororaphis) |
PF13816(Dehydratase_hem) | 3 | SER A 329GLU A 140ASP A 6 | None | 0.65A | 2zulA-3w08A:undetectable | 2zulA-3w08A:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wjt | OUTER-MEMBRANELIPOPROTEIN LOLB (Escherichiacoli) |
PF03550(LolB) | 3 | SER A 41GLU A 72ASP A 68 | None | 0.72A | 2zulA-3wjtA:undetectable | 2zulA-3wjtA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wq4 | BETA-PRIMEVEROSIDASE (Camelliasinensis) |
PF00232(Glyco_hydro_1) | 3 | SER A 206GLU A 470ASP A 421 | None | 0.80A | 2zulA-3wq4A:undetectable | 2zulA-3wq4A:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homo sapiens) |
PF07714(Pkinase_Tyr) | 3 | SER A1986GLU A1997ASP A2079 | None | 0.57A | 2zulA-3zbfA:undetectable | 2zulA-3zbfA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4apm | APICAL MEMBRANEANTIGEN 1 (Babesiadivergens) |
PF02430(AMA-1) | 3 | SER A 462GLU A 330ASP A 407 | None | 0.78A | 2zulA-4apmA:undetectable | 2zulA-4apmA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ay9 | FOLLICLE-STIMULATINGHORMONE RECEPTOR (Homo sapiens) |
PF01462(LRRNT)PF12369(GnHR_trans)PF13306(LRR_5) | 3 | SER X 268GLU X 197ASP X 150 | None | 0.82A | 2zulA-4ay9X:undetectable | 2zulA-4ay9X:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ecg | PUTATIVEIRON-REGULATEDPROTEIN A (Parabacteroidesdistasonis) |
PF09375(Peptidase_M75) | 3 | SER A 113GLU A 299ASP A 275 | None CA A 504 (-3.4A) CA A 506 (-3.0A) | 0.75A | 2zulA-4ecgA:undetectable | 2zulA-4ecgA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eys | MCCC FAMILY PROTEIN (Streptococcuspneumoniae) |
PF02016(Peptidase_S66) | 3 | SER A 146GLU A 171ASP A 174 | NoneAMP A 401 (-3.5A)None | 0.77A | 2zulA-4eysA:undetectable | 2zulA-4eysA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4flx | DNA POLYMERASE 1 (Pyrococcusabyssi) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 3 | SER A 493GLU A 330ASP A 259 | SER A 493 ( 0.0A)GLU A 330 ( 0.5A)ASP A 259 ( 0.6A) | 0.71A | 2zulA-4flxA:undetectable | 2zulA-4flxA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gxt | A CONSERVEDFUNCTIONALLY UNKNOWNPROTEIN (Anaerococcusprevotii) |
PF12710(HAD) | 3 | SER A 318GLU A 54ASP A 246 | None | 0.79A | 2zulA-4gxtA:2.1 | 2zulA-4gxtA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hi7 | GI20122 (Drosophilamojavensis) |
PF00043(GST_C)PF13417(GST_N_3) | 3 | SER A 43GLU A 59ASP A 62 | None | 0.75A | 2zulA-4hi7A:undetectable | 2zulA-4hi7A:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hxq | ARGINASE-1 (Homo sapiens) |
PF00491(Arginase) | 3 | SER A 137GLU A 277ASP A 274 | X8A A 901 (-2.5A)X8A A 901 (-4.0A)None | 0.81A | 2zulA-4hxqA:undetectable | 2zulA-4hxqA:23.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ine | PROTEIN PMT-2 (Caenorhabditiselegans) |
PF08241(Methyltransf_11) | 3 | SER A 10GLU A 105ASP A 109 | None | 0.73A | 2zulA-4ineA:13.9 | 2zulA-4ineA:23.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iqn | PUTATIVE CYTOPLASMICPROTEIN (Salmonellaenterica) |
PF16728(DUF5066) | 3 | SER C 77GLU C 91ASP C 105 | None | 0.75A | 2zulA-4iqnC:undetectable | 2zulA-4iqnC:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iu4 | ARGINASE (Leishmaniamexicana) |
PF00491(Arginase) | 3 | SER A 150GLU A 288ASP A 285 | S2C A 405 (-2.5A)S2C A 405 (-3.6A)None | 0.83A | 2zulA-4iu4A:undetectable | 2zulA-4iu4A:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kss | TYPE II SECRETIONSYSTEM PROTEIN E,HEMOLYSIN-COREGULATED PROTEIN (Pseudomonasaeruginosa;Vibrio cholerae) |
PF00437(T2SSE)PF05638(T6SS_HCP) | 3 | SER A 525GLU A 605ASP A 644 | None | 0.58A | 2zulA-4kssA:2.4 | 2zulA-4kssA:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lix | ENT-COPALYLDIPHOSPHATESYNTHASE,CHLOROPLASTIC (Arabidopsisthaliana) |
PF01397(Terpene_synth)PF03936(Terpene_synth_C) | 3 | SER A 485GLU A 473ASP A 462 | None | 0.74A | 2zulA-4lixA:undetectable | 2zulA-4lixA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mn8 | LRR RECEPTOR-LIKESERINE/THREONINE-PROTEIN KINASE FLS2 (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF13516(LRR_6)PF13855(LRR_8) | 3 | SER A 726GLU A 653ASP A 605 | None | 0.82A | 2zulA-4mn8A:undetectable | 2zulA-4mn8A:18.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mud | RING OXYDATIONCOMPLEX/PHENYLACETIC ACIDDEGRADATION RELATEDPROTEIN (Sulfolobussolfataricus) |
PF05138(PaaA_PaaC) | 3 | SER A 182GLU A 23ASP A 77 | None | 0.75A | 2zulA-4mudA:undetectable | 2zulA-4mudA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n5i | ESTERASE/LIPASE (Lactobacillusrhamnosus) |
PF07859(Abhydrolase_3) | 3 | SER X 94GLU X 29ASP X 22 | NoneNone2HD X 401 ( 4.7A) | 0.53A | 2zulA-4n5iX:undetectable | 2zulA-4n5iX:24.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o6d | NS1 (West Nile virus) |
PF00948(Flavi_NS1) | 3 | SER B 9GLU B 203ASP B 276 | None | 0.78A | 2zulA-4o6dB:undetectable | 2zulA-4o6dB:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oet | PUTATIVE PEPTIDEABC-TRANSPORT SYSTEMPERIPLASMICPEPTIDE-BINDINGPROTEIN (Campylobacterjejuni) |
PF00496(SBP_bac_5) | 3 | SER A 238GLU A 12ASP A 199 | None | 0.60A | 2zulA-4oetA:undetectable | 2zulA-4oetA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rh7 | GREEN FLUORESCENTPROTEIN/CYTOPLASMICDYNEIN 2 HEAVY CHAIN1 (Homo sapiens;syntheticconstruct) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 3 | SER A2669GLU A2713ASP A2783 | NoneADP A4406 ( 4.3A)None | 0.65A | 2zulA-4rh7A:undetectable | 2zulA-4rh7A:8.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ud4 | POLY(A) RNAPOLYMERASE PROTEINCID1 (Schizosaccharomycespombe) |
PF01909(NTP_transf_2)PF03828(PAP_assoc) | 3 | SER A 210GLU A 333ASP A 246 | None | 0.78A | 2zulA-4ud4A:undetectable | 2zulA-4ud4A:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uzz | INTRAFLAGELLARTRANSPORTER-LIKEPROTEIN (Tetrahymenathermophila) |
no annotation | 3 | SER B 544GLU B 567ASP B 560 | None | 0.71A | 2zulA-4uzzB:undetectable | 2zulA-4uzzB:10.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xzb | CELA (Geobacillus sp.70PC53) |
PF00150(Cellulase) | 3 | SER A 274GLU A 142ASP A 184 | None | 0.76A | 2zulA-4xzbA:undetectable | 2zulA-4xzbA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xzw | ENDO-GLUCANASECHIMERA C10 (unculturedbacterium;Geobacillus sp.70PC53) |
PF00150(Cellulase) | 3 | SER A 273GLU A 142ASP A 183 | NoneEPE A 404 (-3.3A)None | 0.77A | 2zulA-4xzwA:undetectable | 2zulA-4xzwA:23.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ypn | LON PROTEASE (Meiothermustaiwanensis) |
PF00004(AAA) | 3 | SER A 280GLU A 269ASP A 457 | None | 0.65A | 2zulA-4ypnA:undetectable | 2zulA-4ypnA:24.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zdh | BETA CHAIN OF JKF6T-CELLRECEPTOR,PROTEINTRBV28 (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 3 | SER B 8GLU B 17ASP B 115 | None | 0.74A | 2zulA-4zdhB:undetectable | 2zulA-4zdhB:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zlv | ORNITHINEAMINOTRANSFERASE,MITOCHONDRIAL,PUTATIVE (Toxoplasmagondii) |
PF00202(Aminotran_3) | 3 | SER A 83GLU A 258ASP A 275 | None | 0.82A | 2zulA-4zlvA:undetectable | 2zulA-4zlvA:25.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b5r | GASDERMIN-A3 (Mus musculus) |
PF04598(Gasdermin) | 3 | SER A 110GLU A 14ASP A 387 | None | 0.79A | 2zulA-5b5rA:undetectable | 2zulA-5b5rA:25.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b83 | TETRA UBIQUITIN (Homo sapiens) |
PF00240(ubiquitin) | 3 | SER A 96GLU A 24ASP A 21 | None | 0.55A | 2zulA-5b83A:undetectable | 2zulA-5b83A:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bsw | 4-COUMARATE--COALIGASE 2 (Nicotianatabacum) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 3 | SER A 523GLU A 337ASP A 401 | None4UW A 600 ( 4.6A)None | 0.80A | 2zulA-5bswA:undetectable | 2zulA-5bswA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5by2 | PHOSPHOHEPTOSEISOMERASE (Colwelliapsychrerythraea) |
PF13580(SIS_2) | 3 | SER A 134GLU A 97ASP A 92 | None | 0.81A | 2zulA-5by2A:3.0 | 2zulA-5by2A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dis | SNURPORTIN-1 (Homo sapiens) |
PF11538(Snurportin1) | 3 | SER C 13GLU C 106ASP C 110 | None | 0.75A | 2zulA-5disC:undetectable | 2zulA-5disC:18.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dl6 | PUTATIVE PORIN FORVANILLATETRAFFICKING (VANP) (Acinetobacterbaumannii) |
PF03573(OprD) | 3 | SER A 227GLU A 309ASP A 347 | None | 0.64A | 2zulA-5dl6A:undetectable | 2zulA-5dl6A:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gs6 | NS1 OF ZIKA VIRUSFROM 2015 BRAZILSTRAIN (Zika virus) |
PF00948(Flavi_NS1) | 3 | SER A 9GLU A 205ASP A 208 | NoneNoneNAG A 601 ( 4.9A) | 0.77A | 2zulA-5gs6A:undetectable | 2zulA-5gs6A:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h12 | DEEP VENT DNAPOLYMERASE (Pyrococcus) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 3 | SER A 493GLU A 330ASP A 259 | None | 0.72A | 2zulA-5h12A:undetectable | 2zulA-5h12A:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jxr | CHROMATIN-REMODELINGCOMPLEX ATPASE-LIKEPROTEIN (Thermothelomycesthermophila) |
PF00176(SNF2_N)PF00271(Helicase_C) | 3 | SER A 516GLU A 132ASP A 126 | None | 0.84A | 2zulA-5jxrA:undetectable | 2zulA-5jxrA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m5p | PRE-MRNA-SPLICINGHELICASE BRR2 (Saccharomycescerevisiae) |
PF00270(DEAD)PF00271(Helicase_C)PF02889(Sec63) | 3 | SER A1921GLU A1267ASP A1225 | None | 0.69A | 2zulA-5m5pA:3.6 | 2zulA-5m5pA:11.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mlg | RENIN (Rattusnorvegicus) |
no annotation | 3 | SER A 270GLU A 24ASP A 29 | None | 0.71A | 2zulA-5mlgA:undetectable | 2zulA-5mlgA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mpm | SARCOPLASMIC/ENDOPLASMIC RETICULUMCALCIUM ATPASE 2 (Sus scrofa) |
no annotation | 3 | SER A 72GLU A 309ASP A 799 | None | 0.77A | 2zulA-5mpmA:undetectable | 2zulA-5mpmA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o0j | ADP-DEPENDENTGLUCOKINASE (Pyrococcushorikoshii) |
no annotation | 3 | SER A 446GLU A 296ASP A 319 | None8BR A 501 ( 4.7A)None | 0.66A | 2zulA-5o0jA:4.1 | 2zulA-5o0jA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5osh | VACUOLAR PROTEINSORTING-ASSOCIATEDPROTEIN 29INTERAPTIN (Homo sapiens;Legionellapneumophila) |
no annotationno annotation | 3 | SER C 154GLU A 178ASP A 154 | None | 0.65A | 2zulA-5oshC:undetectable | 2zulA-5oshC:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u2n | NICOTINAMIDEPHOSPHORIBOSYLTRANSFERASE (Homo sapiens) |
PF04095(NAPRTase) | 3 | SER A 314GLU A 258ASP A 294 | None | 0.60A | 2zulA-5u2nA:undetectable | 2zulA-5u2nA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uqr | 2-METHYLCITRATESYNTHASE,MITOCHONDRIAL (Aspergillusfumigatus) |
no annotation | 3 | SER A 29GLU A 141ASP A 201 | None | 0.82A | 2zulA-5uqrA:undetectable | 2zulA-5uqrA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v9x | ATP-DEPENDENT DNAHELICASE (Mycolicibacteriumsmegmatis) |
no annotation | 3 | SER A 384GLU A 171ASP A 91 | None MG A 906 ( 3.9A)None | 0.81A | 2zulA-5v9xA:3.9 | 2zulA-5v9xA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ve8 | KAP123 (Kluyveromyceslactis) |
no annotation | 3 | SER A 702GLU A 665ASP A 587 | None | 0.68A | 2zulA-5ve8A:undetectable | 2zulA-5ve8A:17.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x9w | DNA MISMATCH REPAIRPROTEIN MUTS (Neisseriagonorrhoeae) |
no annotation | 3 | SER A 7GLU A 34ASP A 31 | None | 0.65A | 2zulA-5x9wA:undetectable | 2zulA-5x9wA:19.68 |