SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZUL_A_SAMA376_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1byo PROTEIN
(PLASTOCYANIN)

(Silene
latifolia) 		PF00127
(Copper-bind) 		5 GLY A  94
LEU A  19
ASP A  42
VAL A  46
VAL A  52
 None
 1.00A 2zulA-1byoA:
undetectable		 2zulA-1byoA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dus MJ0882

(Methanocaldococcus
jannaschii) 		PF05175
(MTS) 		5 PHE A  35
GLY A  63
GLY A  65
ASN A 129
PRO A 131
 None
 0.30A 2zulA-1dusA:
20.4		 2zulA-1dusA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A 534
ALA A 395
ASP A 537
VAL A 542
ASN A 329
 None
NAG  A 604 (-3.4A)
None
None
None
 1.03A 2zulA-1gpeA:
undetectable		 2zulA-1gpeA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 PHE A 130
GLY A 534
ALA A 395
ASP A 537
VAL A 542
 None
None
NAG  A 604 (-3.4A)
None
None
 0.94A 2zulA-1gpeA:
undetectable		 2zulA-1gpeA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gv0 MALATE DEHYDROGENASE

(Chlorobaculum
tepidum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 PHE A 225
GLY A  12
GLY A   9
VAL A  74
VAL A 232
 None
None
NAD  A1306 (-3.2A)
None
None
 1.03A 2zulA-1gv0A:
6.9		 2zulA-1gv0A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7s CATALASE

(Pseudomonas
syringae) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 TYR A 139
GLY A 370
GLY A 367
ALA A 390
VAL A 375
 None
 1.12A 2zulA-1m7sA:
undetectable		 2zulA-1m7sA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ne2 HYPOTHETICAL PROTEIN
TA1320

(Thermoplasma
acidophilum) 		PF06325
(PrmA) 		5 GLY A  56
GLY A  58
LEU A  62
ASN A 114
PRO A 116
 None
 0.91A 2zulA-1ne2A:
15.0		 2zulA-1ne2A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ne2 HYPOTHETICAL PROTEIN
TA1320

(Thermoplasma
acidophilum) 		PF06325
(PrmA) 		6 GLY A  56
GLY A  58
LEU A  62
VAL A 101
ASN A 114
PHE A 128
 None
 0.57A 2zulA-1ne2A:
15.0		 2zulA-1ne2A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))

(Sulfolobus
solfataricus) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 GLY A  84
GLY A 362
ALA A 373
VAL A  25
PHE A 214
 None
 1.01A 2zulA-1qdlA:
undetectable		 2zulA-1qdlA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpg 3-PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		5 TYR A 380
GLY A 211
LEU A 209
ASN A 334
VAL A 376
 None
MAP  A 450 (-3.6A)
None
MAP  A 450 (-3.3A)
None
 1.11A 2zulA-1qpgA:
3.4		 2zulA-1qpgA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyr HIGH LEVEL
KASUGAMYCIN
RESISTANCE PROTEIN

(Escherichia
coli) 		PF00398
(RrnaAD) 		6 GLY A  45
GLY A  47
ALA A  50
LEU A  51
ASN A 113
PRO A 115
 None
 0.70A 2zulA-1qyrA:
10.7		 2zulA-1qyrA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg9 HEMK PROTEIN

(Thermotoga
maritima) 		PF05175
(MTS) 		5 PHE A 100
ALA A 134
ASN A 197
PRO A 199
PHE A 228
 SAM  A 301 ( 3.4A)
SAM  A 301 ( 4.0A)
GLN  A 400 ( 3.1A)
SAM  A 301 ( 4.6A)
None
 1.06A 2zulA-1sg9A:
18.5		 2zulA-1sg9A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg9 HEMK PROTEIN

(Thermotoga
maritima) 		PF05175
(MTS) 		6 PHE A 100
GLY A 129
GLY A 131
ALA A 134
ASN A 197
PRO A 199
 SAM  A 301 ( 3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 ( 3.8A)
SAM  A 301 ( 4.0A)
GLN  A 400 ( 3.1A)
SAM  A 301 ( 4.6A)
 0.49A 2zulA-1sg9A:
18.5		 2zulA-1sg9A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufo HYPOTHETICAL PROTEIN
TT1662

(Thermus
thermophilus) 		no annotation 5 TYR A  77
GLY A  32
GLY A 112
ALA A  29
VAL A  81
 None
 1.12A 2zulA-1ufoA:
undetectable		 2zulA-1ufoA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, BETA
SUBUNIT

(Geobacillus
stearothermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 PHE B 118
GLY B 120
ALA B 211
PRO B 117
PHE B  37
 None
 1.10A 2zulA-1w85B:
undetectable		 2zulA-1w85B:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy7 HYPOTHETICAL PROTEIN
PH1948

(Pyrococcus
horikoshii) 		PF05175
(MTS) 		7 GLY A  57
GLY A  59
LEU A  63
VAL A 106
ASN A 119
PRO A 121
PHE A 133
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 ( 4.3A)
SAH  A1001 (-3.9A)
SAH  A1001 (-4.6A)
None
SAH  A1001 (-4.7A)
 0.61A 2zulA-1wy7A:
14.0		 2zulA-1wy7A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E

(Mus musculus) 		PF00755
(Carn_acyltransf) 		5 GLY A 564
GLY A 562
LEU A 592
VAL A 555
PHE A 566
 None
 1.01A 2zulA-1xl8A:
undetectable		 2zulA-1xl8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl9 GLUTATHIONE
S-TRANSFERASE 5

(Caenorhabditis
elegans) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 PHE A   9
GLY A  13
GLY A  11
VAL A  17
PRO A  54
 GSH  A 501 (-4.7A)
None
None
None
GSH  A 501 (-4.5A)
 1.02A 2zulA-1zl9A:
undetectable		 2zulA-1zl9A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 GLY B  86
ALA B  81
LEU B 132
ASP B 138
PHE B  47
 None
 1.11A 2zulA-2amcB:
undetectable		 2zulA-2amcB:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3t PROTEIN
METHYLTRANSFERASE
HEMK

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		5 GLY A 117
GLY A 119
ALA A 122
ASN A 183
PRO A 185
 SAH  A 300 (-3.4A)
SAH  A 300 (-3.5A)
SAH  A 300 (-3.4A)
SAH  A 300 (-3.9A)
SAH  A 300 ( 3.9A)
 0.56A 2zulA-2b3tA:
21.0		 2zulA-2b3tA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Escherichia
coli) 		PF02233
(PNTB) 		5 PHE C 147
GLY C  38
GLY C  40
ALA C  46
VAL C 118
 None
NAP  C1001 (-3.3A)
NAP  C1001 (-3.5A)
None
None
 0.95A 2zulA-2bruC:
4.3		 2zulA-2bruC:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjs USG-1 PROTEIN
HOMOLOG

(Pseudomonas
aeruginosa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 GLY A  11
GLY A  14
ALA A  19
LEU A  20
VAL A  59
 None
DIO  A 407 (-3.5A)
None
None
None
 1.06A 2zulA-2hjsA:
4.2		 2zulA-2hjsA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnl GLUTATHIONE
S-TRANSFERASE 1

(Onchocerca
volvulus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 PHE A  33
GLY A  37
GLY A  35
VAL A  41
PRO A  76
 None
None
None
None
GSH  A 501 (-4.4A)
 1.11A 2zulA-2hnlA:
undetectable		 2zulA-2hnlA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY

(Rhodobacter
sphaeroides) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 282
GLY A 279
ALA A 314
LEU A 284
VAL A  89
 None
 1.11A 2zulA-2hzgA:
undetectable		 2zulA-2hzgA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i76 HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		PF10728
(DUF2520) 		5 GLY A  26
GLY A  45
ALA A  47
LEU A  29
VAL A   2
 None
 0.99A 2zulA-2i76A:
undetectable		 2zulA-2i76A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jik SYNAPTOJANIN-2
BINDING PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 GLY A  22
GLY A  24
ALA A  54
LEU A  55
ASN A  50
 None
 0.95A 2zulA-2jikA:
undetectable		 2zulA-2jikA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY

(Enterococcus
faecalis) 		PF04198
(Sugar-bind) 		5 GLY A 308
ALA A 315
VAL A 113
VAL A 123
PHE A 127
 None
 1.12A 2zulA-2o0mA:
undetectable		 2zulA-2o0mA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5p FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07660
(STN)
PF07715
(Plug) 		5 PHE A 108
ASP A  67
PRO A  91
VAL A  46
PHE A  48
 None
 1.04A 2zulA-2o5pA:
undetectable		 2zulA-2o5pA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogj DIHYDROOROTASE

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1) 		5 GLY A 226
LEU A 223
VAL A 172
VAL A 104
PHE A 132
 None
 1.12A 2zulA-2ogjA:
undetectable		 2zulA-2ogjA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjd RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE C

(Escherichia
coli) 		PF05175
(MTS)
PF08468
(MTS_N) 		6 GLY A 204
GLY A 206
LEU A 210
VAL A 254
ASN A 268
PRO A 270
 None
 0.86A 2zulA-2pjdA:
32.8		 2zulA-2pjdA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa1 POLYKETIDE OXYGENASE
PGAE

(Streptomyces
sp. PGA64) 		PF01494
(FAD_binding_3) 		5 GLY A  14
GLY A  11
LEU A 103
ASP A 152
VAL A 149
 None
FAD  A 500 (-3.5A)
None
FAD  A 500 (-4.9A)
None
 1.10A 2zulA-2qa1A:
3.2		 2zulA-2qa1A:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqu BETA-FRUCTOFURANOSID
ASE

(Arabidopsis
thaliana) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 PHE A  37
GLY A  84
ALA A 112
ASP A  23
PRO A  27
 None
None
None
SUC  A 800 (-2.6A)
None
 1.12A 2zulA-2qquA:
undetectable		 2zulA-2qquA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Paraburkholderia
phytofirmans) 		PF13407
(Peripla_BP_4) 		5 GLY A 192
ALA A 196
LEU A 197
VAL A 210
PHE A 208
 None
 1.07A 2zulA-2rjoA:
3.2		 2zulA-2rjoA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3p BENZOYL-COA-DIHYDROD
IOL LYASE

(Paraburkholderia
xenovorans) 		PF00378
(ECH_1) 		5 GLY A 142
GLY A 144
ALA A 148
LEU A 149
VAL A 202
 None
 1.00A 2zulA-2w3pA:
undetectable		 2zulA-2w3pA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfg ENDOGLUCANASE 1

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		6 PHE A 432
GLY A 434
GLY A 431
ALA A 324
VAL A  78
PHE A  85
 None
 1.39A 2zulA-2xfgA:
undetectable		 2zulA-2xfgA:
22.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		7 PHE A 207
GLY A 241
GLY A 243
ALA A 246
VAL A 289
PRO A 306
PHE A 322
 SAH  A 376 (-3.4A)
SAH  A 376 (-3.1A)
SAH  A 376 (-3.4A)
SAH  A 376 (-3.3A)
SAH  A 376 (-4.0A)
None
None
 1.49A 2zulA-2zwvA:
64.1		 2zulA-2zwvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		6 TYR A   8
LEU A 219
ASN A 305
PRO A 307
VAL A 318
PHE A 322
 None
None
SAH  A 376 (-4.4A)
SAH  A 376 ( 4.3A)
SAH  A 376 (-4.5A)
None
 1.39A 2zulA-2zwvA:
64.1		 2zulA-2zwvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		12 TYR A   8
PHE A 207
GLY A 241
GLY A 243
ALA A 246
LEU A 247
ASP A 263
VAL A 289
ASN A 305
PRO A 307
VAL A 318
PHE A 322
 None
SAH  A 376 (-3.4A)
SAH  A 376 (-3.1A)
SAH  A 376 (-3.4A)
SAH  A 376 (-3.3A)
SAH  A 376 ( 4.4A)
SAH  A 376 (-4.2A)
SAH  A 376 (-4.0A)
SAH  A 376 (-4.4A)
SAH  A 376 ( 4.3A)
SAH  A 376 (-4.5A)
None
 0.10A 2zulA-2zwvA:
64.1		 2zulA-2zwvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3g LUMAZINE PROTEIN

(Photobacterium
kishitanii) 		PF00677
(Lum_binding) 		5 TYR A 159
GLY A  46
GLY A 100
LEU A  49
VAL A 143
 None
None
None
DLZ  A 191 (-4.2A)
None
 0.99A 2zulA-3a3gA:
undetectable		 2zulA-3a3gA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aex THREONINE SYNTHASE

(Thermus
thermophilus) 		PF00291
(PALP) 		5 PHE A  60
GLY A  64
ALA A 194
LEU A 161
VAL A  69
 AN7  A1001 (-4.7A)
None
None
None
None
 1.06A 2zulA-3aexA:
undetectable		 2zulA-3aexA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjt RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF06325
(PrmA) 		5 PHE A  99
GLY A 128
GLY A 130
LEU A 134
ASN A 191
 SAH  A 258 ( 4.3A)
SAH  A 258 (-3.1A)
SAH  A 258 (-3.6A)
SAH  A 258 (-4.2A)
SAH  A 258 ( 3.8A)
 0.44A 2zulA-3cjtA:
18.4		 2zulA-3cjtA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlc PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE

(Methanococcus
maripaludis) 		PF08241
(Methyltransf_11) 		5 GLY A  50
GLY A  52
ALA A  55
LEU A  56
VAL A 101
 SAM  A 220 (-3.5A)
SAM  A 220 (-3.2A)
SAM  A 220 ( 4.9A)
None
SAM  A 220 ( 4.2A)
 0.80A 2zulA-3dlcA:
11.4		 2zulA-3dlcA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		5 GLY A  38
GLY A  40
LEU A  44
ASN A 101
PRO A 103
 None
 0.83A 2zulA-3fydA:
13.2		 2zulA-3fydA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf6 UNCHARACTERIZED
BACTERIAL
LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12956
(DUF3845) 		5 PHE A 194
GLY A 179
GLY A 183
ASP A  34
VAL A  33
 None
 1.12A 2zulA-3gf6A:
undetectable		 2zulA-3gf6A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gjy SPERMIDINE SYNTHASE

(Corynebacterium
glutamicum) 		no annotation 5 GLY A 235
GLY A 198
ALA A 206
LEU A 203
VAL A 266
 None
 1.12A 2zulA-3gjyA:
12.1		 2zulA-3gjyA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gry DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		5 GLY A  38
GLY A  40
LEU A  44
ASN A 101
PRO A 103
 SAM  A 300 (-3.3A)
SAM  A 300 (-3.3A)
SAM  A 300 ( 4.7A)
SAM  A 300 (-3.6A)
SAM  A 300 (-3.8A)
 0.83A 2zulA-3gryA:
12.5		 2zulA-3gryA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i44 ALDEHYDE
DEHYDROGENASE

(Bartonella
henselae) 		PF00171
(Aldedh) 		5 PHE A 467
GLY A 142
LEU A 220
ASP A 139
PHE A  55
 None
 1.03A 2zulA-3i44A:
4.0		 2zulA-3i44A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ial PROLYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		5 GLY A 481
ALA A 539
LEU A 483
PRO A 255
PHE A 459
 None
None
None
GOL  A 604 (-4.3A)
GOL  A 604 ( 4.2A)
 1.04A 2zulA-3ialA:
undetectable		 2zulA-3ialA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyo QUINATE/SHIKIMATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF08501
(Shikimate_dh_N) 		5 GLY A 134
ALA A 185
LEU A 159
VAL A 138
VAL A 228
 NAD  A 377 ( 3.9A)
NAD  A 377 ( 4.4A)
NAD  A 377 (-4.2A)
NAD  A 377 (-3.8A)
NAD  A 377 (-4.5A)
 1.06A 2zulA-3jyoA:
6.8		 2zulA-3jyoA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Thermoplasma
acidophilum) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		5 GLY A  75
GLY A  77
ALA A  81
LEU A  82
PRO A 227
 None
 0.95A 2zulA-3kd8A:
2.0		 2zulA-3kd8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keq REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX

(Streptococcus
agalactiae) 		PF02629
(CoA_binding)
PF06971
(Put_DNA-bind_N) 		5 GLY A  91
GLY A  93
ALA A  98
LEU A  99
VAL A 164
 NAD  A 213 (-3.6A)
NAD  A 213 (-3.2A)
None
None
NAD  A 213 (-4.8A)
 1.06A 2zulA-3keqA:
5.1		 2zulA-3keqA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		5 TYR A 508
GLY A 273
ALA A 277
LEU A 278
PRO A 411
 FAD  A 690 (-4.2A)
FAD  A 690 (-3.3A)
None
None
CL  A 691 (-4.6A)
 1.00A 2zulA-3pvcA:
10.2		 2zulA-3pvcA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3q ALKALINE PHOSPHATASE

(Sphingomonas
sp. BSAR-1) 		PF01663
(Phosphodiest) 		5 GLY A 492
ALA A  86
VAL A 476
PRO A 396
VAL A 366
 GOL  A8002 (-4.8A)
GOL  A8002 (-3.9A)
None
None
None
 1.10A 2zulA-3q3qA:
undetectable		 2zulA-3q3qA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		6 GLY A 331
LEU A 335
VAL A 389
ASN A 406
PRO A 408
PHE A 447
 SAH  A 900 (-3.2A)
IOD  A 938 (-4.1A)
SAH  A 900 (-3.8A)
SAH  A 900 (-4.5A)
SAH  A 900 (-4.0A)
None
 0.96A 2zulA-3s1sA:
11.1		 2zulA-3s1sA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugg SUCROSE:(SUCROSE/FRU
CTAN)
6-FRUCTOSYLTRANSFERA
SE

(Pachysandra
terminalis) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 PHE A  47
GLY A  94
ALA A 122
ASP A  33
PRO A  37
 None
None
None
DQR  A 800 (-3.0A)
None
 1.11A 2zulA-3uggA:
undetectable		 2zulA-3uggA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzu RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Burkholderia
pseudomallei) 		PF00398
(RrnaAD) 		6 GLY A  46
GLY A  48
ALA A  51
LEU A  52
ASN A 117
PRO A 119
 None
 1.10A 2zulA-3uzuA:
10.7		 2zulA-3uzuA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		5 GLY A 199
LEU A 203
VAL A 291
ASN A 309
PRO A 311
 SAM  A 801 (-3.2A)
SAM  A 801 ( 4.7A)
SAM  A 801 (-3.8A)
SAM  A 801 (-4.5A)
SAM  A 801 ( 4.1A)
 0.58A 2zulA-3v8vA:
15.8		 2zulA-3v8vA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w77 FMN-DEPENDENT
NADH-AZOREDUCTASE

(Bacillus sp.
B29) 		PF02525
(Flavodoxin_2) 		5 PHE A 169
GLY A 171
LEU A 132
VAL A  93
PHE A  87
 None
 0.99A 2zulA-3w77A:
3.1		 2zulA-3w77A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b46 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		5 GLY A 106
GLY A 108
ALA A  70
VAL A 104
VAL A  15
 GDP  A1368 (-3.6A)
GDP  A1368 ( 3.8A)
None
None
None
 1.04A 2zulA-4b46A:
3.5		 2zulA-4b46A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE

(Trypanosoma
brucei) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 PHE A  81
GLY A  79
GLY A 388
ALA A 121
LEU A 125
 None
 1.10A 2zulA-4bi9A:
undetectable		 2zulA-4bi9A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus) 		PF00480
(ROK) 		5 GLY A  63
GLY A 292
ASN A 104
PRO A  65
VAL A  80
 None
 1.00A 2zulA-4db3A:
undetectable		 2zulA-4db3A:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli) 		PF05175
(MTS) 		6 PHE A 208
GLY A 236
GLY A 238
ASN A 305
PRO A 307
VAL A 318
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 3.7A)
SAM  A 401 (-3.8A)
SAM  A 401 (-4.0A)
None
 0.74A 2zulA-4dcmA:
33.7		 2zulA-4dcmA:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doe 1,4-BETA-GLUCANASE

(Caldicellulosiruptor
bescii) 		PF00759
(Glyco_hydro_9) 		6 PHE A 452
GLY A 454
GLY A 451
ALA A 344
VAL A  99
PHE A 106
 None
 1.36A 2zulA-4doeA:
undetectable		 2zulA-4doeA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2i LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1) 		PF06431
(Polyoma_lg_T_C) 		5 GLY A 390
ALA A 574
LEU A 577
VAL A 611
PHE A 607
 None
 1.10A 2zulA-4e2iA:
undetectable		 2zulA-4e2iA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eip PUTATIVE
FAD-MONOOXYGENASE

(Lechevalieria
aerocolonigenes) 		PF01494
(FAD_binding_3) 		5 TYR A 339
GLY A  18
GLY A  14
ALA A 121
LEU A 124
 None
None
FAD  A 602 ( 4.9A)
None
None
 1.04A 2zulA-4eipA:
undetectable		 2zulA-4eipA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eip PUTATIVE
FAD-MONOOXYGENASE

(Lechevalieria
aerocolonigenes) 		PF01494
(FAD_binding_3) 		5 TYR A 339
GLY A  18
GLY A  15
ALA A 121
LEU A 124
 None
None
FAD  A 602 (-3.7A)
None
None
 1.08A 2zulA-4eipA:
undetectable		 2zulA-4eipA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu9 NITRITE EXTRUSION
PROTEIN 2

(Escherichia
coli) 		no annotation 5 PHE B 271
GLY B 266
ALA B 263
VAL B  81
PRO B 419
 None
 1.12A 2zulA-4iu9B:
undetectable		 2zulA-4iu9B:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu9 NITRITE EXTRUSION
PROTEIN 2

(Escherichia
coli) 		no annotation 5 PHE B 271
GLY B 414
GLY B 266
VAL B  81
PRO B 419
 None
 1.01A 2zulA-4iu9B:
undetectable		 2zulA-4iu9B:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jre NITRITE EXTRUSION
PROTEIN 1

(Escherichia
coli) 		PF07690
(MFS_1) 		5 PHE A 273
GLY A 417
GLY A 268
VAL A  83
PRO A 422
 None
GYP  A 502 (-3.4A)
None
None
None
 1.03A 2zulA-4jreA:
undetectable		 2zulA-4jreA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii) 		PF00398
(RrnaAD) 		5 GLY A  50
GLY A  52
LEU A  56
ASN A 116
PRO A 118
 None
 0.80A 2zulA-4jxjA:
10.9		 2zulA-4jxjA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV

(Bacteroides
ovatus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 PHE A 604
GLY A 601
GLY A 606
ALA A 611
LEU A 612
 None
 1.00A 2zulA-4q1vA:
undetectable		 2zulA-4q1vA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q88 UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF07470
(Glyco_hydro_88) 		5 GLY A 357
GLY A 359
ALA A 364
ASP A  54
VAL A 338
 None
 1.08A 2zulA-4q88A:
undetectable		 2zulA-4q88A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb9 ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycolicibacterium
smegmatis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 GLY A 214
ALA A 212
LEU A 221
ASP A 217
VAL A 242
 None
 1.06A 2zulA-4qb9A:
undetectable		 2zulA-4qb9A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 GLY A1002
ALA A1051
LEU A1048
ASP A 936
VAL A 849
 None
 1.04A 2zulA-4rcnA:
undetectable		 2zulA-4rcnA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u39 CELL DIVISION
PROTEIN FTSZ

(Bacillus
subtilis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		6 GLY A  18
GLY A  20
ALA A  49
VAL A  16
ASN A  25
VAL A 194
 None
PO4  A 401 (-3.3A)
None
None
None
None
 1.45A 2zulA-4u39A:
3.5		 2zulA-4u39A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uu9 MEDI7814

(Homo sapiens) 		PF07686
(V-set) 		5 GLY B 101
GLY B  99
ALA B   3
PRO B   7
VAL B  11
 None
 1.06A 2zulA-4uu9B:
undetectable		 2zulA-4uu9B:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1k OUTER MEMBRANE
PROTEIN OPRM

(Pseudomonas
aeruginosa) 		PF02321
(OEP) 		5 PHE A  43
GLY A 447
GLY A 449
ALA A 159
ASP A  37
 None
 1.06A 2zulA-4y1kA:
undetectable		 2zulA-4y1kA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS5

(Saccharomyces
cerevisiae) 		PF00533
(BRCT)
PF16893
(fn3_2) 		5 GLY A 179
ALA A 232
LEU A 229
ASP A 189
PRO A 242
 None
 1.11A 2zulA-4yg8A:
undetectable		 2zulA-4yg8A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv7 LIPASE B

(Moesziomyces
antarcticus) 		no annotation 5 GLY A  39
GLY A  41
ALA A 282
VAL A  37
VAL A 110
 None
 1.01A 2zulA-4zv7A:
undetectable		 2zulA-4zv7A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqf L-LYSINE
6-MONOOXYGENASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13434
(K_oxygenase) 		5 GLY A  17
GLY A  19
ALA A  24
LEU A  25
ASN A 394
 None
 1.07A 2zulA-5cqfA:
2.1		 2zulA-5cqfA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cx0 PEPTIDE DEFORMYLASE

(Xanthomonas
oryzae) 		PF01327
(Pep_deformylase) 		5 TYR A 117
GLY A  46
GLY A  44
ALA A  42
VAL A 139
 None
56L  A 205 (-3.7A)
None
None
None
 1.05A 2zulA-5cx0A:
undetectable		 2zulA-5cx0A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5d PEPTIDE DEFORMYLASE

(Xanthomonas
oryzae) 		PF01327
(Pep_deformylase) 		5 TYR A 117
GLY A  46
GLY A  44
ALA A  42
VAL A 139
 None
 1.09A 2zulA-5e5dA:
undetectable		 2zulA-5e5dA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g6r IMINE REDUCTASE

(Aspergillus
oryzae) 		PF03446
(NAD_binding_2) 		5 GLY A   9
GLY A  11
ALA A  16
LEU A  17
VAL A  71
 NDP  A1000 (-3.5A)
NDP  A1000 (-3.3A)
None
None
NDP  A1000 (-4.4A)
 1.04A 2zulA-5g6rA:
6.1		 2zulA-5g6rA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmt ALGINATE LYASE

(Aplysia kurodai) 		no annotation 5 PHE A  92
GLY A  97
GLY A  95
ALA A 245
ASP A 136
 None
 0.88A 2zulA-5gmtA:
undetectable		 2zulA-5gmtA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h82 HETEROYOHIMBINE
SYNTHASE THAS2

(Catharanthus
roseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PHE A 285
GLY A 199
GLY A 261
LEU A 278
VAL A 211
 None
 1.07A 2zulA-5h82A:
8.9		 2zulA-5h82A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7n MAOC-LIKE
DEHYDRATASE

(Mycobacteroides
abscessus) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		5 PHE A 271
GLY A 267
GLY A 269
LEU A  63
PHE A 332
 None
 1.09A 2zulA-5i7nA:
undetectable		 2zulA-5i7nA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsc PUTATIVE ACYL-COA
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 GLY A 109
ALA A 246
LEU A 245
VAL A  66
VAL A 127
 None
 0.94A 2zulA-5jscA:
undetectable		 2zulA-5jscA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k2z PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.3

(Arabidopsis
thaliana) 		PF01680
(SOR_SNZ) 		5 GLY A 171
GLY A 293
LEU A 296
VAL A 231
VAL A 250
 None
None
None
None
SO4  A 403 ( 4.8A)
 1.11A 2zulA-5k2zA:
undetectable		 2zulA-5k2zA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)

(Helicobacter
pylori) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 GLY A 449
ALA A 457
LEU A 456
VAL A 313
PHE A 392
 None
 1.09A 2zulA-5lp4A:
undetectable		 2zulA-5lp4A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE

(Acaryochloris
marina) 		no annotation 5 TYR A 632
GLY A 612
GLY A 151
ALA A  15
LEU A  18
 None
 1.10A 2zulA-5lpcA:
undetectable		 2zulA-5lpcA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nit GLUCOSE OXIDASE

(Aspergillus
niger) 		no annotation 5 GLY A 530
ALA A 391
ASP A 533
VAL A 538
ASN A 325
 None
NAG  A 609 (-3.5A)
None
None
None
 1.05A 2zulA-5nitA:
3.1		 2zulA-5nitA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nit GLUCOSE OXIDASE

(Aspergillus
niger) 		no annotation 5 PHE A 126
GLY A 530
ALA A 391
ASP A 533
VAL A 538
 None
None
NAG  A 609 (-3.5A)
None
None
 0.99A 2zulA-5nitA:
3.1		 2zulA-5nitA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obn RNA-BINDING PROTEIN
40

(Homo sapiens) 		no annotation 5 GLY A 488
GLY A 397
VAL A 497
VAL A 409
PHE A 410
 None
 0.91A 2zulA-5obnA:
undetectable		 2zulA-5obnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4t PUTATIVE GENTAMICIN
METHYLTRANSFERASE

(Micromonospora
echinospora) 		no annotation 5 GLY A 131
GLY A 133
LEU A 137
ASN A 194
PRO A 196
 SAH  A 414 (-3.0A)
SAH  A 414 (-2.8A)
SAH  A 414 ( 3.7A)
TRS  A 415 ( 2.3A)
SAH  A 414 ( 3.2A)
 0.43A 2zulA-5u4tA:
14.9		 2zulA-5u4tA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uq6 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5

(Sus scrofa) 		PF00149
(Metallophos) 		5 GLY A  51
GLY A  13
ALA A  11
LEU A  48
VAL A 139
 None
 0.90A 2zulA-5uq6A:
undetectable		 2zulA-5uq6A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdn GLUTATHIONE
OXIDOREDUCTASE

(Yersinia pestis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 TYR A 389
PHE A  89
GLY A 198
GLY A 200
LEU A 196
 None
 1.06A 2zulA-5vdnA:
undetectable		 2zulA-5vdnA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0s 60 KDA CHAPERONIN

(Escherichia
coli) 		PF00118
(Cpn60_TCP1) 		5 GLY A 192
GLY A 375
ALA A 373
LEU A 372
VAL A 323
 None
 0.98A 2zulA-5w0sA:
undetectable		 2zulA-5w0sA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgv PYRE3

(Streptomyces
rugosporus) 		no annotation 5 GLY A  14
GLY A  11
LEU A 104
ASP A 150
VAL A 147
 None
FAD  A 501 (-3.5A)
None
None
None
 1.04A 2zulA-5xgvA:
undetectable		 2zulA-5xgvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza -

(-) 		no annotation 5 GLY A 805
GLY A 823
LEU A 783
ASN A 826
PHE A 486
 None
None
None
MGD  A 903 ( 4.6A)
None
 1.11A 2zulA-6czaA:
undetectable		 2zulA-6czaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 5 GLY A 981
GLY A 979
ASN A 524
PRO A 526
VAL A 519
 None
 1.08A 2zulA-6etzA:
undetectable		 2zulA-6etzA:
undetectable