SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZUL_A_SAMA376

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1byo PROTEIN
(PLASTOCYANIN)

(Silene
latifolia) 		PF00127
(Copper-bind) 		5 GLY A  94
LEU A  19
ASP A  42
VAL A  46
VAL A  52
 None
 1.00A 2zulA-1byoA:
undetectable		 2zulA-1byoA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dus MJ0882

(Methanocaldococcus
jannaschii) 		PF05175
(MTS) 		5 PHE A  35
GLY A  63
GLY A  65
ASN A 129
PRO A 131
 None
 0.30A 2zulA-1dusA:
20.4		 2zulA-1dusA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A 534
ALA A 395
ASP A 537
VAL A 542
ASN A 329
 None
NAG  A 604 (-3.4A)
None
None
None
 1.03A 2zulA-1gpeA:
undetectable		 2zulA-1gpeA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 PHE A 130
GLY A 534
ALA A 395
ASP A 537
VAL A 542
 None
None
NAG  A 604 (-3.4A)
None
None
 0.94A 2zulA-1gpeA:
undetectable		 2zulA-1gpeA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gv0 MALATE DEHYDROGENASE

(Chlorobaculum
tepidum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 PHE A 225
GLY A  12
GLY A   9
VAL A  74
VAL A 232
 None
None
NAD  A1306 (-3.2A)
None
None
 1.03A 2zulA-1gv0A:
6.9		 2zulA-1gv0A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7s CATALASE

(Pseudomonas
syringae) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 TYR A 139
GLY A 370
GLY A 367
ALA A 390
VAL A 375
 None
 1.12A 2zulA-1m7sA:
undetectable		 2zulA-1m7sA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ne2 HYPOTHETICAL PROTEIN
TA1320

(Thermoplasma
acidophilum) 		PF06325
(PrmA) 		5 GLY A  56
GLY A  58
LEU A  62
ASN A 114
PRO A 116
 None
 0.91A 2zulA-1ne2A:
15.0		 2zulA-1ne2A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ne2 HYPOTHETICAL PROTEIN
TA1320

(Thermoplasma
acidophilum) 		PF06325
(PrmA) 		6 GLY A  56
GLY A  58
LEU A  62
VAL A 101
ASN A 114
PHE A 128
 None
 0.57A 2zulA-1ne2A:
15.0		 2zulA-1ne2A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))

(Sulfolobus
solfataricus) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 GLY A  84
GLY A 362
ALA A 373
VAL A  25
PHE A 214
 None
 1.01A 2zulA-1qdlA:
undetectable		 2zulA-1qdlA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpg 3-PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		5 TYR A 380
GLY A 211
LEU A 209
ASN A 334
VAL A 376
 None
MAP  A 450 (-3.6A)
None
MAP  A 450 (-3.3A)
None
 1.11A 2zulA-1qpgA:
3.4		 2zulA-1qpgA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyr HIGH LEVEL
KASUGAMYCIN
RESISTANCE PROTEIN

(Escherichia
coli) 		PF00398
(RrnaAD) 		6 GLY A  45
GLY A  47
ALA A  50
LEU A  51
ASN A 113
PRO A 115
 None
 0.70A 2zulA-1qyrA:
10.7		 2zulA-1qyrA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg9 HEMK PROTEIN

(Thermotoga
maritima) 		PF05175
(MTS) 		5 PHE A 100
ALA A 134
ASN A 197
PRO A 199
PHE A 228
 SAM  A 301 ( 3.4A)
SAM  A 301 ( 4.0A)
GLN  A 400 ( 3.1A)
SAM  A 301 ( 4.6A)
None
 1.06A 2zulA-1sg9A:
18.5		 2zulA-1sg9A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg9 HEMK PROTEIN

(Thermotoga
maritima) 		PF05175
(MTS) 		6 PHE A 100
GLY A 129
GLY A 131
ALA A 134
ASN A 197
PRO A 199
 SAM  A 301 ( 3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 ( 3.8A)
SAM  A 301 ( 4.0A)
GLN  A 400 ( 3.1A)
SAM  A 301 ( 4.6A)
 0.49A 2zulA-1sg9A:
18.5		 2zulA-1sg9A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufo HYPOTHETICAL PROTEIN
TT1662

(Thermus
thermophilus) 		no annotation 5 TYR A  77
GLY A  32
GLY A 112
ALA A  29
VAL A  81
 None
 1.12A 2zulA-1ufoA:
undetectable		 2zulA-1ufoA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, BETA
SUBUNIT

(Geobacillus
stearothermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 PHE B 118
GLY B 120
ALA B 211
PRO B 117
PHE B  37
 None
 1.10A 2zulA-1w85B:
undetectable		 2zulA-1w85B:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy7 HYPOTHETICAL PROTEIN
PH1948

(Pyrococcus
horikoshii) 		PF05175
(MTS) 		7 GLY A  57
GLY A  59
LEU A  63
VAL A 106
ASN A 119
PRO A 121
PHE A 133
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 ( 4.3A)
SAH  A1001 (-3.9A)
SAH  A1001 (-4.6A)
None
SAH  A1001 (-4.7A)
 0.61A 2zulA-1wy7A:
14.0		 2zulA-1wy7A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E

(Mus musculus) 		PF00755
(Carn_acyltransf) 		5 GLY A 564
GLY A 562
LEU A 592
VAL A 555
PHE A 566
 None
 1.01A 2zulA-1xl8A:
undetectable		 2zulA-1xl8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl9 GLUTATHIONE
S-TRANSFERASE 5

(Caenorhabditis
elegans) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 PHE A   9
GLY A  13
GLY A  11
VAL A  17
PRO A  54
 GSH  A 501 (-4.7A)
None
None
None
GSH  A 501 (-4.5A)
 1.02A 2zulA-1zl9A:
undetectable		 2zulA-1zl9A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 GLY B  86
ALA B  81
LEU B 132
ASP B 138
PHE B  47
 None
 1.11A 2zulA-2amcB:
undetectable		 2zulA-2amcB:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3t PROTEIN
METHYLTRANSFERASE
HEMK

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		5 GLY A 117
GLY A 119
ALA A 122
ASN A 183
PRO A 185
 SAH  A 300 (-3.4A)
SAH  A 300 (-3.5A)
SAH  A 300 (-3.4A)
SAH  A 300 (-3.9A)
SAH  A 300 ( 3.9A)
 0.56A 2zulA-2b3tA:
21.0		 2zulA-2b3tA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Escherichia
coli) 		PF02233
(PNTB) 		5 PHE C 147
GLY C  38
GLY C  40
ALA C  46
VAL C 118
 None
NAP  C1001 (-3.3A)
NAP  C1001 (-3.5A)
None
None
 0.95A 2zulA-2bruC:
4.3		 2zulA-2bruC:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjs USG-1 PROTEIN
HOMOLOG

(Pseudomonas
aeruginosa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 GLY A  11
GLY A  14
ALA A  19
LEU A  20
VAL A  59
 None
DIO  A 407 (-3.5A)
None
None
None
 1.06A 2zulA-2hjsA:
4.2		 2zulA-2hjsA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnl GLUTATHIONE
S-TRANSFERASE 1

(Onchocerca
volvulus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 PHE A  33
GLY A  37
GLY A  35
VAL A  41
PRO A  76
 None
None
None
None
GSH  A 501 (-4.4A)
 1.11A 2zulA-2hnlA:
undetectable		 2zulA-2hnlA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY

(Rhodobacter
sphaeroides) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 282
GLY A 279
ALA A 314
LEU A 284
VAL A  89
 None
 1.11A 2zulA-2hzgA:
undetectable		 2zulA-2hzgA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i76 HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		PF10728
(DUF2520) 		5 GLY A  26
GLY A  45
ALA A  47
LEU A  29
VAL A   2
 None
 0.99A 2zulA-2i76A:
undetectable		 2zulA-2i76A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jik SYNAPTOJANIN-2
BINDING PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 GLY A  22
GLY A  24
ALA A  54
LEU A  55
ASN A  50
 None
 0.95A 2zulA-2jikA:
undetectable		 2zulA-2jikA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY

(Enterococcus
faecalis) 		PF04198
(Sugar-bind) 		5 GLY A 308
ALA A 315
VAL A 113
VAL A 123
PHE A 127
 None
 1.12A 2zulA-2o0mA:
undetectable		 2zulA-2o0mA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5p FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07660
(STN)
PF07715
(Plug) 		5 PHE A 108
ASP A  67
PRO A  91
VAL A  46
PHE A  48
 None
 1.04A 2zulA-2o5pA:
undetectable		 2zulA-2o5pA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogj DIHYDROOROTASE

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1) 		5 GLY A 226
LEU A 223
VAL A 172
VAL A 104
PHE A 132
 None
 1.12A 2zulA-2ogjA:
undetectable		 2zulA-2ogjA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjd RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE C

(Escherichia
coli) 		PF05175
(MTS)
PF08468
(MTS_N) 		6 GLY A 204
GLY A 206
LEU A 210
VAL A 254
ASN A 268
PRO A 270
 None
 0.86A 2zulA-2pjdA:
32.8		 2zulA-2pjdA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa1 POLYKETIDE OXYGENASE
PGAE

(Streptomyces
sp. PGA64) 		PF01494
(FAD_binding_3) 		5 GLY A  14
GLY A  11
LEU A 103
ASP A 152
VAL A 149
 None
FAD  A 500 (-3.5A)
None
FAD  A 500 (-4.9A)
None
 1.10A 2zulA-2qa1A:
3.2		 2zulA-2qa1A:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqu BETA-FRUCTOFURANOSID
ASE

(Arabidopsis
thaliana) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 PHE A  37
GLY A  84
ALA A 112
ASP A  23
PRO A  27
 None
None
None
SUC  A 800 (-2.6A)
None
 1.12A 2zulA-2qquA:
undetectable		 2zulA-2qquA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Paraburkholderia
phytofirmans) 		PF13407
(Peripla_BP_4) 		5 GLY A 192
ALA A 196
LEU A 197
VAL A 210
PHE A 208
 None
 1.07A 2zulA-2rjoA:
3.2		 2zulA-2rjoA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3p BENZOYL-COA-DIHYDROD
IOL LYASE

(Paraburkholderia
xenovorans) 		PF00378
(ECH_1) 		5 GLY A 142
GLY A 144
ALA A 148
LEU A 149
VAL A 202
 None
 1.00A 2zulA-2w3pA:
undetectable		 2zulA-2w3pA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfg ENDOGLUCANASE 1

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		6 PHE A 432
GLY A 434
GLY A 431
ALA A 324
VAL A  78
PHE A  85
 None
 1.39A 2zulA-2xfgA:
undetectable		 2zulA-2xfgA:
22.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		7 PHE A 207
GLY A 241
GLY A 243
ALA A 246
VAL A 289
PRO A 306
PHE A 322
 SAH  A 376 (-3.4A)
SAH  A 376 (-3.1A)
SAH  A 376 (-3.4A)
SAH  A 376 (-3.3A)
SAH  A 376 (-4.0A)
None
None
 1.49A 2zulA-2zwvA:
64.1		 2zulA-2zwvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		6 TYR A   8
LEU A 219
ASN A 305
PRO A 307
VAL A 318
PHE A 322
 None
None
SAH  A 376 (-4.4A)
SAH  A 376 ( 4.3A)
SAH  A 376 (-4.5A)
None
 1.39A 2zulA-2zwvA:
64.1		 2zulA-2zwvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		12 TYR A   8
PHE A 207
GLY A 241
GLY A 243
ALA A 246
LEU A 247
ASP A 263
VAL A 289
ASN A 305
PRO A 307
VAL A 318
PHE A 322
 None
SAH  A 376 (-3.4A)
SAH  A 376 (-3.1A)
SAH  A 376 (-3.4A)
SAH  A 376 (-3.3A)
SAH  A 376 ( 4.4A)
SAH  A 376 (-4.2A)
SAH  A 376 (-4.0A)
SAH  A 376 (-4.4A)
SAH  A 376 ( 4.3A)
SAH  A 376 (-4.5A)
None
 0.10A 2zulA-2zwvA:
64.1		 2zulA-2zwvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3g LUMAZINE PROTEIN

(Photobacterium
kishitanii) 		PF00677
(Lum_binding) 		5 TYR A 159
GLY A  46
GLY A 100
LEU A  49
VAL A 143
 None
None
None
DLZ  A 191 (-4.2A)
None
 0.99A 2zulA-3a3gA:
undetectable		 2zulA-3a3gA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aex THREONINE SYNTHASE

(Thermus
thermophilus) 		PF00291
(PALP) 		5 PHE A  60
GLY A  64
ALA A 194
LEU A 161
VAL A  69
 AN7  A1001 (-4.7A)
None
None
None
None
 1.06A 2zulA-3aexA:
undetectable		 2zulA-3aexA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjt RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF06325
(PrmA) 		5 PHE A  99
GLY A 128
GLY A 130
LEU A 134
ASN A 191
 SAH  A 258 ( 4.3A)
SAH  A 258 (-3.1A)
SAH  A 258 (-3.6A)
SAH  A 258 (-4.2A)
SAH  A 258 ( 3.8A)
 0.44A 2zulA-3cjtA:
18.4		 2zulA-3cjtA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlc PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE

(Methanococcus
maripaludis) 		PF08241
(Methyltransf_11) 		5 GLY A  50
GLY A  52
ALA A  55
LEU A  56
VAL A 101
 SAM  A 220 (-3.5A)
SAM  A 220 (-3.2A)
SAM  A 220 ( 4.9A)
None
SAM  A 220 ( 4.2A)
 0.80A 2zulA-3dlcA:
11.4		 2zulA-3dlcA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		5 GLY A  38
GLY A  40
LEU A  44
ASN A 101
PRO A 103
 None
 0.83A 2zulA-3fydA:
13.2		 2zulA-3fydA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf6 UNCHARACTERIZED
BACTERIAL
LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12956
(DUF3845) 		5 PHE A 194
GLY A 179
GLY A 183
ASP A  34
VAL A  33
 None
 1.12A 2zulA-3gf6A:
undetectable		 2zulA-3gf6A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gjy SPERMIDINE SYNTHASE

(Corynebacterium
glutamicum) 		no annotation 5 GLY A 235
GLY A 198
ALA A 206
LEU A 203
VAL A 266
 None
 1.12A 2zulA-3gjyA:
12.1		 2zulA-3gjyA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gry DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		5 GLY A  38
GLY A  40
LEU A  44
ASN A 101
PRO A 103
 SAM  A 300 (-3.3A)
SAM  A 300 (-3.3A)
SAM  A 300 ( 4.7A)
SAM  A 300 (-3.6A)
SAM  A 300 (-3.8A)
 0.83A 2zulA-3gryA:
12.5		 2zulA-3gryA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i44 ALDEHYDE
DEHYDROGENASE

(Bartonella
henselae) 		PF00171
(Aldedh) 		5 PHE A 467
GLY A 142
LEU A 220
ASP A 139
PHE A  55
 None
 1.03A 2zulA-3i44A:
4.0		 2zulA-3i44A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ial PROLYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		5 GLY A 481
ALA A 539
LEU A 483
PRO A 255
PHE A 459
 None
None
None
GOL  A 604 (-4.3A)
GOL  A 604 ( 4.2A)
 1.04A 2zulA-3ialA:
undetectable		 2zulA-3ialA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyo QUINATE/SHIKIMATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF08501
(Shikimate_dh_N) 		5 GLY A 134
ALA A 185
LEU A 159
VAL A 138
VAL A 228
 NAD  A 377 ( 3.9A)
NAD  A 377 ( 4.4A)
NAD  A 377 (-4.2A)
NAD  A 377 (-3.8A)
NAD  A 377 (-4.5A)
 1.06A 2zulA-3jyoA:
6.8		 2zulA-3jyoA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Thermoplasma
acidophilum) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		5 GLY A  75
GLY A  77
ALA A  81
LEU A  82
PRO A 227
 None
 0.95A 2zulA-3kd8A:
2.0		 2zulA-3kd8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keq REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX

(Streptococcus
agalactiae) 		PF02629
(CoA_binding)
PF06971
(Put_DNA-bind_N) 		5 GLY A  91
GLY A  93
ALA A  98
LEU A  99
VAL A 164
 NAD  A 213 (-3.6A)
NAD  A 213 (-3.2A)
None
None
NAD  A 213 (-4.8A)
 1.06A 2zulA-3keqA:
5.1		 2zulA-3keqA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		5 TYR A 508
GLY A 273
ALA A 277
LEU A 278
PRO A 411
 FAD  A 690 (-4.2A)
FAD  A 690 (-3.3A)
None
None
CL  A 691 (-4.6A)
 1.00A 2zulA-3pvcA:
10.2		 2zulA-3pvcA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3q ALKALINE PHOSPHATASE

(Sphingomonas
sp. BSAR-1) 		PF01663
(Phosphodiest) 		5 GLY A 492
ALA A  86
VAL A 476
PRO A 396
VAL A 366
 GOL  A8002 (-4.8A)
GOL  A8002 (-3.9A)
None
None
None
 1.10A 2zulA-3q3qA:
undetectable		 2zulA-3q3qA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		6 GLY A 331
LEU A 335
VAL A 389
ASN A 406
PRO A 408
PHE A 447
 SAH  A 900 (-3.2A)
IOD  A 938 (-4.1A)
SAH  A 900 (-3.8A)
SAH  A 900 (-4.5A)
SAH  A 900 (-4.0A)
None
 0.96A 2zulA-3s1sA:
11.1		 2zulA-3s1sA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugg SUCROSE:(SUCROSE/FRU
CTAN)
6-FRUCTOSYLTRANSFERA
SE

(Pachysandra
terminalis) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 PHE A  47
GLY A  94
ALA A 122
ASP A  33
PRO A  37
 None
None
None
DQR  A 800 (-3.0A)
None
 1.11A 2zulA-3uggA:
undetectable		 2zulA-3uggA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzu RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Burkholderia
pseudomallei) 		PF00398
(RrnaAD) 		6 GLY A  46
GLY A  48
ALA A  51
LEU A  52
ASN A 117
PRO A 119
 None
 1.10A 2zulA-3uzuA:
10.7		 2zulA-3uzuA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		5 GLY A 199
LEU A 203
VAL A 291
ASN A 309
PRO A 311
 SAM  A 801 (-3.2A)
SAM  A 801 ( 4.7A)
SAM  A 801 (-3.8A)
SAM  A 801 (-4.5A)
SAM  A 801 ( 4.1A)
 0.58A 2zulA-3v8vA:
15.8		 2zulA-3v8vA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w77 FMN-DEPENDENT
NADH-AZOREDUCTASE

(Bacillus sp.
B29) 		PF02525
(Flavodoxin_2) 		5 PHE A 169
GLY A 171
LEU A 132
VAL A  93
PHE A  87
 None
 0.99A 2zulA-3w77A:
3.1		 2zulA-3w77A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b46 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		5 GLY A 106
GLY A 108
ALA A  70
VAL A 104
VAL A  15
 GDP  A1368 (-3.6A)
GDP  A1368 ( 3.8A)
None
None
None
 1.04A 2zulA-4b46A:
3.5		 2zulA-4b46A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE

(Trypanosoma
brucei) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 PHE A  81
GLY A  79
GLY A 388
ALA A 121
LEU A 125
 None
 1.10A 2zulA-4bi9A:
undetectable		 2zulA-4bi9A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus) 		PF00480
(ROK) 		5 GLY A  63
GLY A 292
ASN A 104
PRO A  65
VAL A  80
 None
 1.00A 2zulA-4db3A:
undetectable		 2zulA-4db3A:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli) 		PF05175
(MTS) 		6 PHE A 208
GLY A 236
GLY A 238
ASN A 305
PRO A 307
VAL A 318
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 3.7A)
SAM  A 401 (-3.8A)
SAM  A 401 (-4.0A)
None
 0.74A 2zulA-4dcmA:
33.7		 2zulA-4dcmA:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doe 1,4-BETA-GLUCANASE

(Caldicellulosiruptor
bescii) 		PF00759
(Glyco_hydro_9) 		6 PHE A 452
GLY A 454
GLY A 451
ALA A 344
VAL A  99
PHE A 106
 None
 1.36A 2zulA-4doeA:
undetectable		 2zulA-4doeA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2i LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1) 		PF06431
(Polyoma_lg_T_C) 		5 GLY A 390
ALA A 574
LEU A 577
VAL A 611
PHE A 607
 None
 1.10A 2zulA-4e2iA:
undetectable		 2zulA-4e2iA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eip PUTATIVE
FAD-MONOOXYGENASE

(Lechevalieria
aerocolonigenes) 		PF01494
(FAD_binding_3) 		5 TYR A 339
GLY A  18
GLY A  14
ALA A 121
LEU A 124
 None
None
FAD  A 602 ( 4.9A)
None
None
 1.04A 2zulA-4eipA:
undetectable		 2zulA-4eipA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eip PUTATIVE
FAD-MONOOXYGENASE

(Lechevalieria
aerocolonigenes) 		PF01494
(FAD_binding_3) 		5 TYR A 339
GLY A  18
GLY A  15
ALA A 121
LEU A 124
 None
None
FAD  A 602 (-3.7A)
None
None
 1.08A 2zulA-4eipA:
undetectable		 2zulA-4eipA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu9 NITRITE EXTRUSION
PROTEIN 2

(Escherichia
coli) 		no annotation 5 PHE B 271
GLY B 266
ALA B 263
VAL B  81
PRO B 419
 None
 1.12A 2zulA-4iu9B:
undetectable		 2zulA-4iu9B:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu9 NITRITE EXTRUSION
PROTEIN 2

(Escherichia
coli) 		no annotation 5 PHE B 271
GLY B 414
GLY B 266
VAL B  81
PRO B 419
 None
 1.01A 2zulA-4iu9B:
undetectable		 2zulA-4iu9B:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jre NITRITE EXTRUSION
PROTEIN 1

(Escherichia
coli) 		PF07690
(MFS_1) 		5 PHE A 273
GLY A 417
GLY A 268
VAL A  83
PRO A 422
 None
GYP  A 502 (-3.4A)
None
None
None
 1.03A 2zulA-4jreA:
undetectable		 2zulA-4jreA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii) 		PF00398
(RrnaAD) 		5 GLY A  50
GLY A  52
LEU A  56
ASN A 116
PRO A 118
 None
 0.80A 2zulA-4jxjA:
10.9		 2zulA-4jxjA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV

(Bacteroides
ovatus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 PHE A 604
GLY A 601
GLY A 606
ALA A 611
LEU A 612
 None
 1.00A 2zulA-4q1vA:
undetectable		 2zulA-4q1vA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q88 UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF07470
(Glyco_hydro_88) 		5 GLY A 357
GLY A 359
ALA A 364
ASP A  54
VAL A 338
 None
 1.08A 2zulA-4q88A:
undetectable		 2zulA-4q88A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb9 ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycolicibacterium
smegmatis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 GLY A 214
ALA A 212
LEU A 221
ASP A 217
VAL A 242
 None
 1.06A 2zulA-4qb9A:
undetectable		 2zulA-4qb9A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 GLY A1002
ALA A1051
LEU A1048
ASP A 936
VAL A 849
 None
 1.04A 2zulA-4rcnA:
undetectable		 2zulA-4rcnA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u39 CELL DIVISION
PROTEIN FTSZ

(Bacillus
subtilis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		6 GLY A  18
GLY A  20
ALA A  49
VAL A  16
ASN A  25
VAL A 194
 None
PO4  A 401 (-3.3A)
None
None
None
None
 1.45A 2zulA-4u39A:
3.5		 2zulA-4u39A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uu9 MEDI7814

(Homo sapiens) 		PF07686
(V-set) 		5 GLY B 101
GLY B  99
ALA B   3
PRO B   7
VAL B  11
 None
 1.06A 2zulA-4uu9B:
undetectable		 2zulA-4uu9B:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1k OUTER MEMBRANE
PROTEIN OPRM

(Pseudomonas
aeruginosa) 		PF02321
(OEP) 		5 PHE A  43
GLY A 447
GLY A 449
ALA A 159
ASP A  37
 None
 1.06A 2zulA-4y1kA:
undetectable		 2zulA-4y1kA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS5

(Saccharomyces
cerevisiae) 		PF00533
(BRCT)
PF16893
(fn3_2) 		5 GLY A 179
ALA A 232
LEU A 229
ASP A 189
PRO A 242
 None
 1.11A 2zulA-4yg8A:
undetectable		 2zulA-4yg8A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv7 LIPASE B

(Moesziomyces
antarcticus) 		no annotation 5 GLY A  39
GLY A  41
ALA A 282
VAL A  37
VAL A 110
 None
 1.01A 2zulA-4zv7A:
undetectable		 2zulA-4zv7A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqf L-LYSINE
6-MONOOXYGENASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13434
(K_oxygenase) 		5 GLY A  17
GLY A  19
ALA A  24
LEU A  25
ASN A 394
 None
 1.07A 2zulA-5cqfA:
2.1		 2zulA-5cqfA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cx0 PEPTIDE DEFORMYLASE

(Xanthomonas
oryzae) 		PF01327
(Pep_deformylase) 		5 TYR A 117
GLY A  46
GLY A  44
ALA A  42
VAL A 139
 None
56L  A 205 (-3.7A)
None
None
None
 1.05A 2zulA-5cx0A:
undetectable		 2zulA-5cx0A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5d PEPTIDE DEFORMYLASE

(Xanthomonas
oryzae) 		PF01327
(Pep_deformylase) 		5 TYR A 117
GLY A  46
GLY A  44
ALA A  42
VAL A 139
 None
 1.09A 2zulA-5e5dA:
undetectable		 2zulA-5e5dA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g6r IMINE REDUCTASE

(Aspergillus
oryzae) 		PF03446
(NAD_binding_2) 		5 GLY A   9
GLY A  11
ALA A  16
LEU A  17
VAL A  71
 NDP  A1000 (-3.5A)
NDP  A1000 (-3.3A)
None
None
NDP  A1000 (-4.4A)
 1.04A 2zulA-5g6rA:
6.1		 2zulA-5g6rA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmt ALGINATE LYASE

(Aplysia kurodai) 		no annotation 5 PHE A  92
GLY A  97
GLY A  95
ALA A 245
ASP A 136
 None
 0.88A 2zulA-5gmtA:
undetectable		 2zulA-5gmtA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h82 HETEROYOHIMBINE
SYNTHASE THAS2

(Catharanthus
roseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PHE A 285
GLY A 199
GLY A 261
LEU A 278
VAL A 211
 None
 1.07A 2zulA-5h82A:
8.9		 2zulA-5h82A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7n MAOC-LIKE
DEHYDRATASE

(Mycobacteroides
abscessus) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		5 PHE A 271
GLY A 267
GLY A 269
LEU A  63
PHE A 332
 None
 1.09A 2zulA-5i7nA:
undetectable		 2zulA-5i7nA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsc PUTATIVE ACYL-COA
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 GLY A 109
ALA A 246
LEU A 245
VAL A  66
VAL A 127
 None
 0.94A 2zulA-5jscA:
undetectable		 2zulA-5jscA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k2z PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.3

(Arabidopsis
thaliana) 		PF01680
(SOR_SNZ) 		5 GLY A 171
GLY A 293
LEU A 296
VAL A 231
VAL A 250
 None
None
None
None
SO4  A 403 ( 4.8A)
 1.11A 2zulA-5k2zA:
undetectable		 2zulA-5k2zA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)

(Helicobacter
pylori) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 GLY A 449
ALA A 457
LEU A 456
VAL A 313
PHE A 392
 None
 1.09A 2zulA-5lp4A:
undetectable		 2zulA-5lp4A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE

(Acaryochloris
marina) 		no annotation 5 TYR A 632
GLY A 612
GLY A 151
ALA A  15
LEU A  18
 None
 1.10A 2zulA-5lpcA:
undetectable		 2zulA-5lpcA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nit GLUCOSE OXIDASE

(Aspergillus
niger) 		no annotation 5 GLY A 530
ALA A 391
ASP A 533
VAL A 538
ASN A 325
 None
NAG  A 609 (-3.5A)
None
None
None
 1.05A 2zulA-5nitA:
3.1		 2zulA-5nitA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nit GLUCOSE OXIDASE

(Aspergillus
niger) 		no annotation 5 PHE A 126
GLY A 530
ALA A 391
ASP A 533
VAL A 538
 None
None
NAG  A 609 (-3.5A)
None
None
 0.99A 2zulA-5nitA:
3.1		 2zulA-5nitA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obn RNA-BINDING PROTEIN
40

(Homo sapiens) 		no annotation 5 GLY A 488
GLY A 397
VAL A 497
VAL A 409
PHE A 410
 None
 0.91A 2zulA-5obnA:
undetectable		 2zulA-5obnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4t PUTATIVE GENTAMICIN
METHYLTRANSFERASE

(Micromonospora
echinospora) 		no annotation 5 GLY A 131
GLY A 133
LEU A 137
ASN A 194
PRO A 196
 SAH  A 414 (-3.0A)
SAH  A 414 (-2.8A)
SAH  A 414 ( 3.7A)
TRS  A 415 ( 2.3A)
SAH  A 414 ( 3.2A)
 0.43A 2zulA-5u4tA:
14.9		 2zulA-5u4tA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uq6 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5

(Sus scrofa) 		PF00149
(Metallophos) 		5 GLY A  51
GLY A  13
ALA A  11
LEU A  48
VAL A 139
 None
 0.90A 2zulA-5uq6A:
undetectable		 2zulA-5uq6A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdn GLUTATHIONE
OXIDOREDUCTASE

(Yersinia pestis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 TYR A 389
PHE A  89
GLY A 198
GLY A 200
LEU A 196
 None
 1.06A 2zulA-5vdnA:
undetectable		 2zulA-5vdnA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0s 60 KDA CHAPERONIN

(Escherichia
coli) 		PF00118
(Cpn60_TCP1) 		5 GLY A 192
GLY A 375
ALA A 373
LEU A 372
VAL A 323
 None
 0.98A 2zulA-5w0sA:
undetectable		 2zulA-5w0sA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgv PYRE3

(Streptomyces
rugosporus) 		no annotation 5 GLY A  14
GLY A  11
LEU A 104
ASP A 150
VAL A 147
 None
FAD  A 501 (-3.5A)
None
None
None
 1.04A 2zulA-5xgvA:
undetectable		 2zulA-5xgvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza -

(-) 		no annotation 5 GLY A 805
GLY A 823
LEU A 783
ASN A 826
PHE A 486
 None
None
None
MGD  A 903 ( 4.6A)
None
 1.11A 2zulA-6czaA:
undetectable		 2zulA-6czaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 5 GLY A 981
GLY A 979
ASN A 524
PRO A 526
VAL A 519
 None
 1.08A 2zulA-6etzA:
undetectable		 2zulA-6etzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b55 TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF00169
(PH)
PF00779
(BTK) 		3 SER A  21
GLU A 108
ASP A  57
 4IP  A 171 (-2.5A)
None
None
 0.81A 2zulA-1b55A:
undetectable		 2zulA-1b55A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1buy PROTEIN
(ERYTHROPOIETIN)

(Homo sapiens) 		PF00758
(EPO_TPO) 		3 SER A 120
GLU A  62
ASP A  43
 None
 0.60A 2zulA-1buyA:
undetectable		 2zulA-1buyA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)

(Physarum
polycephalum) 		PF09192
(Act-Frag_cataly) 		3 SER A 233
GLU A 163
ASP A  60
 None
 0.70A 2zulA-1cjaA:
undetectable		 2zulA-1cjaA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ez4 LACTATE
DEHYDROGENASE

(Lactobacillus
pentosus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 SER A 317
GLU A 230
ASP A 223
 None
 0.80A 2zulA-1ez4A:
7.0		 2zulA-1ez4A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyx ENOLASE

(Enterococcus
hirae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 SER A 369
GLU A 246
ASP A 291
 SO4  A1002 (-3.1A)
None
None
 0.81A 2zulA-1iyxA:
undetectable		 2zulA-1iyxA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n10 POLLEN ALLERGEN PHL
P 1

(Phleum pratense) 		PF01357
(Pollen_allerg_1)
PF03330
(DPBB_1) 		3 SER A1085
GLU A1075
ASP A1017
 None
 0.64A 2zulA-1n10A:
undetectable		 2zulA-1n10A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1omo ALANINE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF02423
(OCD_Mu_crystall) 		3 SER A 186
GLU A 249
ASP A 219
 SER  A 186 ( 0.0A)
GLU  A 249 (-0.6A)
ASP  A 219 (-0.5A)
 0.65A 2zulA-1omoA:
5.0		 2zulA-1omoA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p8r ARGINASE 1

(Rattus
norvegicus) 		PF00491
(Arginase) 		3 SER A 137
GLU A 277
ASP A 274
 S2C  A 551 (-3.3A)
S2C  A 551 (-3.6A)
None
 0.75A 2zulA-1p8rA:
3.2		 2zulA-1p8rA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1psz PROTEIN (SURFACE
ANTIGEN PSAA)

(Streptococcus
pneumoniae) 		PF01297
(ZnuA) 		3 SER A 212
GLU A 254
ASP A  65
 None
 0.78A 2zulA-1pszA:
undetectable		 2zulA-1pszA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu2 ISOLEUCYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00133
(tRNA-synt_1)
PF06827
(zf-FPG_IleRS)
PF08264
(Anticodon_1) 		3 SER A 856
GLU A 887
ASP A   2
 None
 0.65A 2zulA-1qu2A:
undetectable		 2zulA-1qu2A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 41 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C)
PF13177
(DNA_pol3_delta2) 		3 SER E 183
GLU D 141
ASP D  99
 None
MG  D 814 (-3.4A)
None
 0.74A 2zulA-1sxjE:
2.5		 2zulA-1sxjE:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlf LAC REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		3 SER A  85
GLU A 277
ASP A 247
 None
 0.58A 2zulA-1tlfA:
4.7		 2zulA-1tlfA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9x POLY (ADP-RIBOSE)
POLYMERASE

(Arabidopsis
thaliana) 		PF00645
(zf-PARP) 		3 SER A   3
GLU A  73
ASP A  71
 None
 0.73A 2zulA-1v9xA:
undetectable		 2zulA-1v9xA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vho ENDOGLUCANASE

(Thermotoga
maritima) 		PF05343
(Peptidase_M42) 		3 SER A 174
GLU A 274
ASP A 236
 SER  A 174 ( 0.0A)
GLU  A 274 ( 0.6A)
ASP  A 236 ( 0.6A)
 0.80A 2zulA-1vhoA:
undetectable		 2zulA-1vhoA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF04095
(NAPRTase) 		3 SER A 102
GLU A 382
ASP A 401
 None
 0.76A 2zulA-1vlpA:
undetectable		 2zulA-1vlpA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y12 HYPOTHETICAL PROTEIN
PA0085

(Pseudomonas
aeruginosa) 		PF05638
(T6SS_HCP) 		3 SER A  16
GLU A  96
ASP A 135
 None
 0.66A 2zulA-1y12A:
undetectable		 2zulA-1y12A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zef ALKALINE PHOSPHATASE

(Homo sapiens) 		PF00245
(Alk_phosphatase) 		3 SER A 287
GLU A 339
ASP A  72
 None
 0.81A 2zulA-1zefA:
2.1		 2zulA-1zefA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5l DIPEPTIDYL
AMINOPEPTIDASE IV,
PUTATIVE

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 SER A 290
GLU A 329
ASP A 358
 None
 0.80A 2zulA-2d5lA:
undetectable		 2zulA-2d5lA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecz SORBIN AND SH3
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00018
(SH3_1) 		3 SER A   3
GLU A  44
ASP A  39
 None
 0.81A 2zulA-2eczA:
undetectable		 2zulA-2eczA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbo VARIABLE
REGION-CONTAINING
CHITIN-BINDING
PROTEIN 3

(Branchiostoma
floridae) 		PF07686
(V-set) 		3 SER J 202
GLU J 119
ASP J 123
 None
 0.83A 2zulA-2fboJ:
undetectable		 2zulA-2fboJ:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqy CONSERVED
HYPOTHETICAL PROTEIN

(Bacteroides
thetaiotaomicron) 		PF09924
(DUF2156) 		3 SER A  36
GLU A 268
ASP A 117
 None
 0.81A 2zulA-2hqyA:
undetectable		 2zulA-2hqyA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iiz MELANIN BIOSYNTHESIS
PROTEIN TYRA,
PUTATIVE

(Shewanella
oneidensis) 		PF04261
(Dyp_perox) 		3 SER A 237
GLU A 213
ASP A 218
 None
HEM  A 400 ( 4.7A)
None
 0.82A 2zulA-2iizA:
undetectable		 2zulA-2iizA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3m PROLYL-TRNA
SYNTHETASE

(Enterococcus
faecalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF04073
(tRNA_edit) 		3 SER A 147
GLU A 407
ASP A 198
 None
MN  A1567 (-2.5A)
None
 0.83A 2zulA-2j3mA:
undetectable		 2zulA-2j3mA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kmw UNCHARACTERIZED
PROTEIN AT3G03773

(Arabidopsis
thaliana) 		PF04969
(CS) 		3 SER A 119
GLU A 112
ASP A 108
 None
 0.82A 2zulA-2kmwA:
undetectable		 2zulA-2kmwA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paf LACTOSE OPERON
REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		3 SER A  85
GLU A 277
ASP A 247
 None
 0.68A 2zulA-2pafA:
4.5		 2zulA-2pafA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptz ENOLASE

(Trypanosoma
brucei) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 SER A  37
GLU A 248
ASP A 295
 None
 0.83A 2zulA-2ptzA:
undetectable		 2zulA-2ptzA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxt PROTEIN SUFI

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 SER A 313
GLU A 392
ASP A 361
 None
 0.72A 2zulA-2uxtA:
undetectable		 2zulA-2uxtA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwk DNA POLYMERASE

(Thermococcus
gorgonarius) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 SER A 492
GLU A 330
ASP A 259
 None
 0.55A 2zulA-2vwkA:
undetectable		 2zulA-2vwkA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6g XYLANASE

(Rhodothermus
marinus) 		PF02018
(CBM_4_9) 		3 SER A  48
GLU A  95
ASP A  97
 None
 0.79A 2zulA-2y6gA:
undetectable		 2zulA-2y6gA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yf0 MYOTUBULARIN-RELATED
PROTEIN 6

(Homo sapiens) 		PF06602
(Myotub-related) 		3 SER A 344
GLU A 369
ASP A 129
 None
 0.75A 2zulA-2yf0A:
undetectable		 2zulA-2yf0A:
21.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		3 SER A 216
GLU A 262
ASP A 288
 SAH  A 376 (-2.5A)
SAH  A 376 (-2.7A)
SAH  A 376 (-4.1A)
 0.06A 2zulA-2zwvA:
64.1		 2zulA-2zwvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE

(Pyrococcus
furiosus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 SER A 493
GLU A 330
ASP A 259
 None
 0.71A 2zulA-3a2fA:
undetectable		 2zulA-3a2fA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9t TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Methylobacillus
flagellatus) 		PF03069
(FmdA_AmdA) 		3 SER A 305
GLU A 350
ASP A 348
 None
EDO  A 494 (-3.5A)
EDO  A 495 (-4.1A)
 0.77A 2zulA-3b9tA:
undetectable		 2zulA-3b9tA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1

(Cavia porcellus) 		PF00106
(adh_short) 		3 SER A  67
GLU A 221
ASP A 219
 NAP  A 301 (-4.9A)
SO4  A   1 (-4.6A)
None
 0.83A 2zulA-3dwfA:
4.0		 2zulA-3dwfA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4f AMINOGLYCOSIDE
N3-ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF02522
(Antibiotic_NAT) 		3 SER A 157
GLU A 186
ASP A 220
 None
 0.81A 2zulA-3e4fA:
undetectable		 2zulA-3e4fA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG

(Homo sapiens) 		PF09445
(Methyltransf_15) 		3 SER A 688
GLU A 827
ASP A 660
 None
 0.65A 2zulA-3egiA:
11.8		 2zulA-3egiA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgb UNCHARACTERIZED
PROTEIN Q89ZH8_BACTN

(Bacteroides
thetaiotaomicron) 		PF10282
(Lactonase) 		3 SER A  75
GLU A 252
ASP A 276
 None
 0.83A 2zulA-3fgbA:
undetectable		 2zulA-3fgbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fh3 PUTATIVE ECF-TYPE
SIGMA FACTOR
NEGATIVE EFFECTOR

(Bacillus
anthracis) 		PF12207
(DUF3600) 		3 SER A 130
GLU A 151
ASP A 158
 None
 0.71A 2zulA-3fh3A:
undetectable		 2zulA-3fh3A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hh8 METAL ABC
TRANSPORTER
SUBSTRATE-BINDING
LIPOPROTEIN

(Streptococcus
pyogenes) 		PF01297
(ZnuA) 		3 SER A 212
GLU A 254
ASP A  65
 None
 0.74A 2zulA-3hh8A:
undetectable		 2zulA-3hh8A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A

(Drosophila
melanogaster) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		3 SER A 141
GLU A  57
ASP A  34
 None
 0.78A 2zulA-3i2tA:
undetectable		 2zulA-3i2tA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF10

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2) 		3 SER B 363
GLU B 387
ASP B 285
 None
 0.64A 2zulA-3jb9B:
undetectable		 2zulA-3jb9B:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE

(Streptococcus
agalactiae) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 SER A 383
GLU A  45
ASP A  39
 None
 0.83A 2zulA-3lk7A:
4.6		 2zulA-3lk7A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n8u IMELYSIN PEPTIDASE

(Bacteroides
ovatus) 		PF09375
(Peptidase_M75) 		3 SER A 308
GLU A 137
ASP A 119
 None
MG  A   1 ( 4.6A)
None
 0.79A 2zulA-3n8uA:
undetectable		 2zulA-3n8uA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqh GLYCOSYL HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		3 SER A 223
GLU A 105
ASP A 126
 None
GOL  A 501 (-2.8A)
None
 0.62A 2zulA-3nqhA:
undetectable		 2zulA-3nqhA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ph9 ANTERIOR GRADIENT
PROTEIN 3 HOMOLOG

(Homo sapiens) 		PF13899
(Thioredoxin_7) 		3 SER A  74
GLU A 103
ASP A 106
 None
 0.55A 2zulA-3ph9A:
undetectable		 2zulA-3ph9A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 SER A 423
GLU A 487
ASP A 176
 None
 0.57A 2zulA-3pocA:
undetectable		 2zulA-3pocA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqd L-LACTATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 SER A 239
GLU A 182
ASP A 216
 None
 0.70A 2zulA-3pqdA:
6.5		 2zulA-3pqdA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3quc INORGANIC
PYROPHOSPHATASE

(Bacteroides
thetaiotaomicron) 		PF13419
(HAD_2) 		3 SER A  53
GLU A 178
ASP A 202
 None
 0.81A 2zulA-3qucA:
3.3		 2zulA-3qucA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sim PROTEIN, FAMILY 18
CHITINASE

(Crocus vernus) 		PF00704
(Glyco_hydro_18) 		3 SER A  34
GLU A 266
ASP A 262
 None
 0.59A 2zulA-3simA:
undetectable		 2zulA-3simA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujg SERINE/THREONINE-PRO
TEIN KINASE SRK2E

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		3 SER A  29
GLU A  65
ASP A  59
 None
 0.69A 2zulA-3ujgA:
undetectable		 2zulA-3ujgA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4h HYPOTHETICAL PROTEIN

(Yersinia pestis) 		PF05638
(T6SS_HCP) 		3 SER A  16
GLU A  95
ASP A 135
 None
 0.75A 2zulA-3v4hA:
undetectable		 2zulA-3v4hA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w08 ALDOXIME DEHYDRATASE

(Pseudomonas
chlororaphis) 		PF13816
(Dehydratase_hem) 		3 SER A 329
GLU A 140
ASP A   6
 None
 0.65A 2zulA-3w08A:
undetectable		 2zulA-3w08A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjt OUTER-MEMBRANE
LIPOPROTEIN LOLB

(Escherichia
coli) 		PF03550
(LolB) 		3 SER A  41
GLU A  72
ASP A  68
 None
 0.72A 2zulA-3wjtA:
undetectable		 2zulA-3wjtA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq4 BETA-PRIMEVEROSIDASE

(Camellia
sinensis) 		PF00232
(Glyco_hydro_1) 		3 SER A 206
GLU A 470
ASP A 421
 None
 0.80A 2zulA-3wq4A:
undetectable		 2zulA-3wq4A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 SER A1986
GLU A1997
ASP A2079
 None
 0.57A 2zulA-3zbfA:
undetectable		 2zulA-3zbfA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apm APICAL MEMBRANE
ANTIGEN 1

(Babesia
divergens) 		PF02430
(AMA-1) 		3 SER A 462
GLU A 330
ASP A 407
 None
 0.78A 2zulA-4apmA:
undetectable		 2zulA-4apmA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay9 FOLLICLE-STIMULATING
HORMONE RECEPTOR

(Homo sapiens) 		PF01462
(LRRNT)
PF12369
(GnHR_trans)
PF13306
(LRR_5) 		3 SER X 268
GLU X 197
ASP X 150
 None
 0.82A 2zulA-4ay9X:
undetectable		 2zulA-4ay9X:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecg PUTATIVE
IRON-REGULATED
PROTEIN A

(Parabacteroides
distasonis) 		PF09375
(Peptidase_M75) 		3 SER A 113
GLU A 299
ASP A 275
 None
CA  A 504 (-3.4A)
CA  A 506 (-3.0A)
 0.75A 2zulA-4ecgA:
undetectable		 2zulA-4ecgA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eys MCCC FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF02016
(Peptidase_S66) 		3 SER A 146
GLU A 171
ASP A 174
 None
AMP  A 401 (-3.5A)
None
 0.77A 2zulA-4eysA:
undetectable		 2zulA-4eysA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 SER A 493
GLU A 330
ASP A 259
 SER  A 493 ( 0.0A)
GLU  A 330 ( 0.5A)
ASP  A 259 ( 0.6A)
 0.71A 2zulA-4flxA:
undetectable		 2zulA-4flxA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN

(Anaerococcus
prevotii) 		PF12710
(HAD) 		3 SER A 318
GLU A  54
ASP A 246
 None
 0.79A 2zulA-4gxtA:
2.1		 2zulA-4gxtA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hi7 GI20122

(Drosophila
mojavensis) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		3 SER A  43
GLU A  59
ASP A  62
 None
 0.75A 2zulA-4hi7A:
undetectable		 2zulA-4hi7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxq ARGINASE-1

(Homo sapiens) 		PF00491
(Arginase) 		3 SER A 137
GLU A 277
ASP A 274
 X8A  A 901 (-2.5A)
X8A  A 901 (-4.0A)
None
 0.81A 2zulA-4hxqA:
undetectable		 2zulA-4hxqA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		3 SER A  10
GLU A 105
ASP A 109
 None
 0.73A 2zulA-4ineA:
13.9		 2zulA-4ineA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqn PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF16728
(DUF5066) 		3 SER C  77
GLU C  91
ASP C 105
 None
 0.75A 2zulA-4iqnC:
undetectable		 2zulA-4iqnC:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu4 ARGINASE

(Leishmania
mexicana) 		PF00491
(Arginase) 		3 SER A 150
GLU A 288
ASP A 285
 S2C  A 405 (-2.5A)
S2C  A 405 (-3.6A)
None
 0.83A 2zulA-4iu4A:
undetectable		 2zulA-4iu4A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kss TYPE II SECRETION
SYSTEM PROTEIN E,
HEMOLYSIN-COREGULATE
D PROTEIN

(Pseudomonas
aeruginosa;
Vibrio cholerae) 		PF00437
(T2SSE)
PF05638
(T6SS_HCP) 		3 SER A 525
GLU A 605
ASP A 644
 None
 0.58A 2zulA-4kssA:
2.4		 2zulA-4kssA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lix ENT-COPALYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 SER A 485
GLU A 473
ASP A 462
 None
 0.74A 2zulA-4lixA:
undetectable		 2zulA-4lixA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		3 SER A 726
GLU A 653
ASP A 605
 None
 0.82A 2zulA-4mn8A:
undetectable		 2zulA-4mn8A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mud RING OXYDATION
COMPLEX/
PHENYLACETIC ACID
DEGRADATION RELATED
PROTEIN

(Sulfolobus
solfataricus) 		PF05138
(PaaA_PaaC) 		3 SER A 182
GLU A  23
ASP A  77
 None
 0.75A 2zulA-4mudA:
undetectable		 2zulA-4mudA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5i ESTERASE/LIPASE

(Lactobacillus
rhamnosus) 		PF07859
(Abhydrolase_3) 		3 SER X  94
GLU X  29
ASP X  22
 None
None
2HD  X 401 ( 4.7A)
 0.53A 2zulA-4n5iX:
undetectable		 2zulA-4n5iX:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6d NS1

(West Nile virus) 		PF00948
(Flavi_NS1) 		3 SER B   9
GLU B 203
ASP B 276
 None
 0.78A 2zulA-4o6dB:
undetectable		 2zulA-4o6dB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oet PUTATIVE PEPTIDE
ABC-TRANSPORT SYSTEM
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00496
(SBP_bac_5) 		3 SER A 238
GLU A  12
ASP A 199
 None
 0.60A 2zulA-4oetA:
undetectable		 2zulA-4oetA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 SER A2669
GLU A2713
ASP A2783
 None
ADP  A4406 ( 4.3A)
None
 0.65A 2zulA-4rh7A:
undetectable		 2zulA-4rh7A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud4 POLY(A) RNA
POLYMERASE PROTEIN
CID1

(Schizosaccharomyces
pombe) 		PF01909
(NTP_transf_2)
PF03828
(PAP_assoc) 		3 SER A 210
GLU A 333
ASP A 246
 None
 0.78A 2zulA-4ud4A:
undetectable		 2zulA-4ud4A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzz INTRAFLAGELLAR
TRANSPORTER-LIKE
PROTEIN

(Tetrahymena
thermophila) 		no annotation 3 SER B 544
GLU B 567
ASP B 560
 None
 0.71A 2zulA-4uzzB:
undetectable		 2zulA-4uzzB:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzb CELA

(Geobacillus sp.
70PC53) 		PF00150
(Cellulase) 		3 SER A 274
GLU A 142
ASP A 184
 None
 0.76A 2zulA-4xzbA:
undetectable		 2zulA-4xzbA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzw ENDO-GLUCANASE
CHIMERA C10

(uncultured
bacterium;
Geobacillus sp.
70PC53) 		PF00150
(Cellulase) 		3 SER A 273
GLU A 142
ASP A 183
 None
EPE  A 404 (-3.3A)
None
 0.77A 2zulA-4xzwA:
undetectable		 2zulA-4xzwA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypn LON PROTEASE

(Meiothermus
taiwanensis) 		PF00004
(AAA) 		3 SER A 280
GLU A 269
ASP A 457
 None
 0.65A 2zulA-4ypnA:
undetectable		 2zulA-4ypnA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdh BETA CHAIN OF JKF6
T-CELL
RECEPTOR,PROTEIN
TRBV28

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B   8
GLU B  17
ASP B 115
 None
 0.74A 2zulA-4zdhB:
undetectable		 2zulA-4zdhB:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE

(Toxoplasma
gondii) 		PF00202
(Aminotran_3) 		3 SER A  83
GLU A 258
ASP A 275
 None
 0.82A 2zulA-4zlvA:
undetectable		 2zulA-4zlvA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5r GASDERMIN-A3

(Mus musculus) 		PF04598
(Gasdermin) 		3 SER A 110
GLU A  14
ASP A 387
 None
 0.79A 2zulA-5b5rA:
undetectable		 2zulA-5b5rA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b83 TETRA UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		3 SER A  96
GLU A  24
ASP A  21
 None
 0.55A 2zulA-5b83A:
undetectable		 2zulA-5b83A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsw 4-COUMARATE--COA
LIGASE 2

(Nicotiana
tabacum) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 SER A 523
GLU A 337
ASP A 401
 None
4UW  A 600 ( 4.6A)
None
 0.80A 2zulA-5bswA:
undetectable		 2zulA-5bswA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by2 PHOSPHOHEPTOSE
ISOMERASE

(Colwellia
psychrerythraea) 		PF13580
(SIS_2) 		3 SER A 134
GLU A  97
ASP A  92
 None
 0.81A 2zulA-5by2A:
3.0		 2zulA-5by2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis SNURPORTIN-1

(Homo sapiens) 		PF11538
(Snurportin1) 		3 SER C  13
GLU C 106
ASP C 110
 None
 0.75A 2zulA-5disC:
undetectable		 2zulA-5disC:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl6 PUTATIVE PORIN FOR
VANILLATE
TRAFFICKING (VANP)

(Acinetobacter
baumannii) 		PF03573
(OprD) 		3 SER A 227
GLU A 309
ASP A 347
 None
 0.64A 2zulA-5dl6A:
undetectable		 2zulA-5dl6A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs6 NS1 OF ZIKA VIRUS
FROM 2015 BRAZIL
STRAIN

(Zika virus) 		PF00948
(Flavi_NS1) 		3 SER A   9
GLU A 205
ASP A 208
 None
None
NAG  A 601 ( 4.9A)
 0.77A 2zulA-5gs6A:
undetectable		 2zulA-5gs6A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h12 DEEP VENT DNA
POLYMERASE

(Pyrococcus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 SER A 493
GLU A 330
ASP A 259
 None
 0.72A 2zulA-5h12A:
undetectable		 2zulA-5h12A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		3 SER A 516
GLU A 132
ASP A 126
 None
 0.84A 2zulA-5jxrA:
undetectable		 2zulA-5jxrA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		3 SER A1921
GLU A1267
ASP A1225
 None
 0.69A 2zulA-5m5pA:
3.6		 2zulA-5m5pA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 3 SER A 270
GLU A  24
ASP A  29
 None
 0.71A 2zulA-5mlgA:
undetectable		 2zulA-5mlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 2

(Sus scrofa) 		no annotation 3 SER A  72
GLU A 309
ASP A 799
 None
 0.77A 2zulA-5mpmA:
undetectable		 2zulA-5mpmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii) 		no annotation 3 SER A 446
GLU A 296
ASP A 319
 None
8BR  A 501 ( 4.7A)
None
 0.66A 2zulA-5o0jA:
4.1		 2zulA-5o0jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osh VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29
INTERAPTIN

(Homo sapiens;
Legionella
pneumophila) 		no annotation
no annotation 		3 SER C 154
GLU A 178
ASP A 154
 None
 0.65A 2zulA-5oshC:
undetectable		 2zulA-5oshC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE

(Homo sapiens) 		PF04095
(NAPRTase) 		3 SER A 314
GLU A 258
ASP A 294
 None
 0.60A 2zulA-5u2nA:
undetectable		 2zulA-5u2nA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL

(Aspergillus
fumigatus) 		no annotation 3 SER A  29
GLU A 141
ASP A 201
 None
 0.82A 2zulA-5uqrA:
undetectable		 2zulA-5uqrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9x ATP-DEPENDENT DNA
HELICASE

(Mycolicibacterium
smegmatis) 		no annotation 3 SER A 384
GLU A 171
ASP A  91
 None
MG  A 906 ( 3.9A)
None
 0.81A 2zulA-5v9xA:
3.9		 2zulA-5v9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve8 KAP123

(Kluyveromyces
lactis) 		no annotation 3 SER A 702
GLU A 665
ASP A 587
 None
 0.68A 2zulA-5ve8A:
undetectable		 2zulA-5ve8A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 3 SER A   7
GLU A  34
ASP A  31
 None
 0.65A 2zulA-5x9wA:
undetectable		 2zulA-5x9wA:
19.68