SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZTH_A_SAMA305_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg6 N-(1-D-CARBOXYLETHYL
)-L-NORVALINE
DEHYDROGENASE

(Arthrobacter
sp. 1C) 		PF02317
(Octopine_DH)
PF02558
(ApbA) 		5 VAL A  30
GLY A  16
TYR A   7
SER A 144
HIS A  17
 None
 1.43A 2zthA-1bg6A:
5.9		 2zthA-1bg6A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		5 VAL A 116
GLY A 152
TYR A 105
SER A 174
GLN A  80
 None
 1.50A 2zthA-1cu1A:
3.8		 2zthA-1cu1A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmy BILE-SALT-ACTIVATED
LIPASE

(Homo sapiens) 		PF00135
(COesterase) 		5 VAL A 290
GLY A 146
MET A 111
TYR A 143
GLN A  71
 None
 1.42A 2zthA-1jmyA:
2.7		 2zthA-1jmyA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kv9 TYPE II
QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		5 GLY A  22
MET A 235
TYR A  25
HIS A  21
ARG A 111
 None
None
None
None
PQQ  A 801 (-3.3A)
 1.35A 2zthA-1kv9A:
undetectable		 2zthA-1kv9A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldk CULLIN HOMOLOG

(Homo sapiens) 		PF00888
(Cullin) 		5 VAL A 132
TYR A  46
TYR A  42
ASN A  51
ARG A  91
 None
 1.34A 2zthA-1ldkA:
undetectable		 2zthA-1ldkA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 130
GLY A 119
TYR A 122
SER A  40
HIS A  68
 None
None
None
NAD  A 401 (-2.9A)
None
 1.31A 2zthA-2eerA:
8.3		 2zthA-2eerA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkp HOMOACONITASE SMALL
SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00694
(Aconitase_C) 		5 VAL A  82
GLY A  62
TYR A  92
SER A  65
ARG A  67
 None
 1.42A 2zthA-2pkpA:
2.2		 2zthA-2pkpA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xlr FLAVIN-CONTAINING
MONOOXYGENASE

(Methylophaga
aminisulfidivorans) 		PF00743
(FMO-like) 		5 VAL A 121
GLY A  19
TYR A 124
GLN A 323
TRP A  52
 None
None
None
FAD  A 500 ( 3.2A)
FAD  A 500 (-4.2A)
 1.17A 2zthA-2xlrA:
3.0		 2zthA-2xlrA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvu PROBABLE
ADENYLYL-SULFATE
KINASE

(Aeropyrum
pernix) 		PF01583
(APS_kinase) 		5 VAL A 181
TYR A 176
TYR A 178
ASN A 168
SER A  24
 None
 1.46A 2zthA-2yvuA:
undetectable		 2zthA-2yvuA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bo6 HYDROPHILIC PROTEIN,
VIRA PROTEIN

(Chromobacterium
violaceum) 		PF03536
(VRP3) 		5 VAL A 114
TYR A 209
SER A 200
HIS A 106
ARG A 213
 None
None
SO4  A   1 ( 4.5A)
SO4  A   1 (-3.9A)
SO4  A   1 (-3.8A)
 1.27A 2zthA-3bo6A:
undetectable		 2zthA-3bo6A:
23.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bwm CATECHOL
O-METHYLTRANSFERASE

(Homo sapiens) 		PF01596
(Methyltransf_3) 		5 GLY A  66
TYR A  68
SER A 119
HIS A 142
ARG A 146
 SAM  A 301 (-3.2A)
SAM  A 301 (-4.7A)
SAM  A 301 (-3.1A)
SAM  A 301 ( 4.9A)
None
 1.13A 2zthA-3bwmA:
35.9		 2zthA-3bwmA:
80.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bwm CATECHOL
O-METHYLTRANSFERASE

(Homo sapiens) 		PF01596
(Methyltransf_3) 		9 VAL A  42
GLY A  66
TYR A  68
TYR A  71
ASN A  92
SER A 119
GLN A 120
HIS A 142
ARG A 146
 SAM  A 301 ( 3.7A)
SAM  A 301 (-3.2A)
SAM  A 301 (-4.7A)
None
None
SAM  A 301 (-3.1A)
SAM  A 301 (-3.6A)
SAM  A 301 ( 4.9A)
None
 0.56A 2zthA-3bwmA:
35.9		 2zthA-3bwmA:
80.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE

(Comamonas
testosteroni) 		PF00155
(Aminotran_1_2) 		5 VAL A 197
GLY A 200
TYR A 207
ASN A 256
GLN A 232
 None
None
PLP  A 534 (-4.9A)
PLP  A 534 (-3.8A)
None
 1.48A 2zthA-3fddA:
4.2		 2zthA-3fddA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvr ACETYL XYLAN
ESTERASE

(Bacillus
pumilus) 		PF05448
(AXE1) 		5 GLY A 152
TYR A 148
TYR A 247
TYR A 150
SER A  67
 None
 1.50A 2zthA-3fvrA:
2.6		 2zthA-3fvrA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		5 VAL W 811
TYR W1019
TYR W 938
SER W 987
HIS W 989
 None
 1.24A 2zthA-3iylW:
7.1		 2zthA-3iylW:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntv MW1564 PROTEIN

(Staphylococcus
aureus) 		PF01596
(Methyltransf_3) 		5 VAL A  55
GLY A  79
TYR A  84
ASN A 104
GLN A 154
 SO4  A 233 (-4.2A)
None
SO4  A 233 (-4.9A)
None
None
 1.23A 2zthA-3ntvA:
14.6		 2zthA-3ntvA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o21 GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 VAL A  27
GLY A   9
TYR A  71
SER A  64
HIS A  46
 None
 0.96A 2zthA-3o21A:
6.0		 2zthA-3o21A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae) 		PF00291
(PALP) 		5 VAL A  51
GLY A  75
TYR A  87
TYR A 108
SER A  71
 None
 1.35A 2zthA-3x43A:
4.7		 2zthA-3x43A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0n POLYKETIDE SYNTHASE
III

(Ectocarpus
siliculosus) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 GLY A 246
TYR A  92
TYR A  55
TYR A 362
SER A 367
 None
 1.49A 2zthA-4b0nA:
undetectable		 2zthA-4b0nA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be3 ALGINATE LYASE,
FAMILY PL7

(Zobellia
galactanivorans) 		PF08787
(Alginate_lyase2) 		5 VAL A 174
GLY A 146
TYR A 163
TYR A 299
GLN A 108
 None
 1.47A 2zthA-4be3A:
undetectable		 2zthA-4be3A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be3 ALGINATE LYASE,
FAMILY PL7

(Zobellia
galactanivorans) 		PF08787
(Alginate_lyase2) 		5 VAL A 174
GLY A 146
TYR A 163
TYR A 299
GLN A 292
 None
 1.17A 2zthA-4be3A:
undetectable		 2zthA-4be3A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2t DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 VAL A 283
GLY A 254
TYR A 284
SER A 259
ARG A 609
 None
 1.34A 2zthA-4c2tA:
undetectable		 2zthA-4c2tA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		5 VAL A  72
GLY A 309
TYR A  57
SER A 144
ARG A 142
 None
 1.22A 2zthA-4eygA:
4.4		 2zthA-4eygA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmb CYSTEINE SYNTHASE

(Microcystis
aeruginosa) 		PF00291
(PALP) 		5 VAL A  54
GLY A  79
TYR A  91
TYR A 112
SER A  75
 None
None
None
None
CYS  A 401 ( 2.6A)
 1.23A 2zthA-4lmbA:
3.5		 2zthA-4lmbA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqs CYP105AS1

(Amycolatopsis
orientalis) 		PF00067
(p450) 		5 VAL A 282
GLY A 241
SER A 155
GLN A 173
HIS A 242
 HEM  A 501 ( 4.8A)
HEM  A 501 (-3.2A)
None
None
None
 1.47A 2zthA-4oqsA:
undetectable		 2zthA-4oqsA:
21.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p58 CATECHOL
O-METHYLTRANSFERASE

(Mus musculus) 		PF01596
(Methyltransf_3) 		8 GLY A 109
TYR A 114
ASN A 135
TYR A 138
SER A 162
GLN A 163
HIS A 185
ARG A 189
 2F6  A 301 (-3.6A)
None
None
None
2F6  A 301 (-3.2A)
2F6  A 301 (-3.8A)
None
None
 0.52A 2zthA-4p58A:
34.1		 2zthA-4p58A:
97.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pp1 LIGHT CHAIN OF FAB
FRAGMENT OF MAB 5H8
HEAVY CHAIN OF FAB
FRAGMENT OF MAB 5H8

(Mus musculus;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 GLY C  91
TYR D 104
ASN C  31
TYR C  50
GLN C  27
 None
 1.15A 2zthA-4pp1C:
undetectable		 2zthA-4pp1C:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwy TRYPSIN-1

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY A  56
TYR A 234
SER A 195
HIS A  57
TRP A 215
 None
 1.06A 2zthA-4wwyA:
undetectable		 2zthA-4wwyA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 VAL A 714
TYR A 645
ASN A 566
TYR A 565
SER A 654
 None
None
GOL  A 804 (-4.6A)
None
None
 1.49A 2zthA-4zo6A:
undetectable		 2zthA-4zo6A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		5 GLY A1054
TYR A1167
ASN A1074
SER A1399
GLN A1400
 None
 1.45A 2zthA-5gzuA:
undetectable		 2zthA-5gzuA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1y PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41

(Homo sapiens) 		PF00270
(DEAD) 		5 VAL A 239
TYR A 280
TYR A 279
HIS A 274
ARG A 271
 None
 1.50A 2zthA-5h1yA:
5.0		 2zthA-5h1yA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE

(Thermotoga
neapolitana) 		PF00232
(Glyco_hydro_1) 		5 VAL A 262
TYR A 269
TYR A 186
HIS A 193
ARG A 135
 None
 1.48A 2zthA-5idiA:
undetectable		 2zthA-5idiA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jia RAN-BINDING PROTEIN
10

(Mus musculus) 		PF00622
(SPRY) 		5 GLY A  67
SER A  69
GLN A  70
HIS A  76
ARG A  74
 None
 1.33A 2zthA-5jiaA:
undetectable		 2zthA-5jiaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5upb ACETOACETATE
DECARBOXYLASE

(Sphingomonas
wittichii) 		PF06314
(ADC) 		5 GLY A 183
TYR A  99
ASN A 118
SER A 198
HIS A 184
 None
 1.31A 2zthA-5upbA:
undetectable		 2zthA-5upbA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6s ACETYLXYLAN ESTERASE
A

(Aspergillus
awamori) 		PF10503
(Esterase_phd) 		5 GLY A 144
TYR A 142
TYR A  39
TYR A 197
TRP A 217
 None
 1.43A 2zthA-5x6sA:
3.3		 2zthA-5x6sA:
21.74