SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZT7_A_GLYA1300_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ati GLYCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 GLU A 188
GLU A 239
ARG A 311
GLU A 359
SER A 361
 None
 0.65A 2zt7A-1atiA:
33.2		 2zt7A-1atiA:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bc5 CHEMOTAXIS RECEPTOR
METHYLTRANSFERASE

(Salmonella
enterica) 		PF01739
(CheR)
PF03705
(CheR_N) 		4 ARG A  98
GLU A 264
TYR A 235
SER A 263
 SAH  A 287 (-3.9A)
None
None
None
 1.17A 2zt7A-1bc5A:
undetectable		 2zt7A-1bc5A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbw ENDO-1,4-BETA-GLUCAN
ASE F

([Clostridium]
cellulolyticum) 		PF02011
(Glyco_hydro_48) 		4 ARG A 421
TYR A  59
GLU A 615
SER A 500
 None
 1.18A 2zt7A-1fbwA:
undetectable		 2zt7A-1fbwA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggm GLYCINE--TRNA LIGASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		7 GLU A 188
ARG A 220
GLU A 239
TYR A 287
ARG A 311
GLU A 359
SER A 361
 GAP  A1550 ( 2.6A)
GAP  A1550 ( 2.4A)
GAP  A1550 ( 2.2A)
None
GAP  A1550 (-3.8A)
GAP  A1550 ( 2.7A)
GAP  A1550 ( 2.4A)
 0.59A 2zt7A-1ggmA:
34.7		 2zt7A-1ggmA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpo MALTOPORIN

(Escherichia
coli) 		PF02264
(LamB) 		4 ARG A   8
GLU A  43
TYR A 118
ARG A 109
 GLC  A 432 (-2.8A)
GLC  A 432 ( 2.9A)
GLC  A 433 (-4.6A)
GLC  A 432 (-3.3A)
 1.27A 2zt7A-1mpoA:
undetectable		 2zt7A-1mpoA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus;
Bos taurus) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C) 		4 GLU D 751
ARG D 857
GLU A 203
ARG A 202
 None
 1.16A 2zt7A-1o7dD:
0.9		 2zt7A-1o7dD:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuo PUTATIVE
PHOSPHOMANNOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ARG A 440
GLU A 333
GLU A 332
SER A 334
 None
 1.14A 2zt7A-1tuoA:
3.8		 2zt7A-1tuoA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8o BACTERIAL SIALIDASE

(Micromonospora
viridifaciens) 		PF00754
(F5_F8_type_C)
PF10633
(NPCBM_assoc)
PF13088
(BNR_2) 		4 ARG A  87
ARG A 276
GLU A 260
SER A 206
 CIT  A1649 (-3.0A)
CIT  A1649 ( 2.7A)
GOL  A1651 (-3.6A)
None
 1.24A 2zt7A-1w8oA:
undetectable		 2zt7A-1w8oA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Desulfovibrio
africanus) 		PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II) 		4 GLU A 281
TYR A 258
ARG A 303
SER A 145
 None
 1.14A 2zt7A-2c3oA:
2.4		 2zt7A-2c3oA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3a GLUTAMINE SYNTHETASE

(Zea mays) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 ARG A 316
GLU A 129
TYR A 158
GLU A 199
 ADP  A6001 (-2.8A)
MN  A1002 ( 2.0A)
P3S  A5001 ( 4.9A)
MN  A1001 ( 2.5A)
 1.17A 2zt7A-2d3aA:
undetectable		 2zt7A-2d3aA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Staphylococcus
aureus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 GLU B 150
ARG B 120
GLU B 124
SER B  93
 MG  B 601 (-3.1A)
None
MG  B 601 (-2.5A)
None
 1.17A 2zt7A-2f2aB:
1.4		 2zt7A-2f2aB:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fiy PROTEIN FDHE HOMOLOG

(Pseudomonas
aeruginosa) 		PF04216
(FdhE) 		4 ARG A  32
ARG A 198
GLU A 217
SER A 210
 None
 1.22A 2zt7A-2fiyA:
undetectable		 2zt7A-2fiyA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzf HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		PF02915
(Rubrerythrin) 		4 GLU A 117
GLU A 147
TYR A  39
GLU A  62
 None
 1.26A 2zt7A-2fzfA:
undetectable		 2zt7A-2fzfA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR

(Mycobacterium
tuberculosis) 		PF02515
(CoA_transf_3) 		4 GLU A  90
ARG A  91
ARG A 110
GLU A  82
 None
CAA  A1751 (-2.2A)
None
None
 0.99A 2zt7A-2gd2A:
undetectable		 2zt7A-2gd2A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcj N-ACETYLLACTOSAMINID
E
ALPHA-1,3-GALACTOSYL
TRANSFERASE

(Bos taurus) 		PF03414
(Glyco_transf_6) 		4 GLU A 110
GLU A 336
TYR A 113
SER A 334
 None
 1.24A 2zt7A-2jcjA:
undetectable		 2zt7A-2jcjA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpr MALTOPORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 ARG A   8
GLU A  43
TYR A 118
ARG A 109
 GLC  A 429 (-3.0A)
GLC  A 429 ( 2.6A)
BGC  A 428 (-4.4A)
GLC  A 429 ( 3.0A)
 1.21A 2zt7A-2mprA:
undetectable		 2zt7A-2mprA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ob5 HYPOTHETICAL PROTEIN
ATU2016

(Agrobacterium
fabrum) 		PF05025
(RbsD_FucU) 		4 GLU A  94
ARG A 134
GLU A 132
SER A  54
 None
 1.16A 2zt7A-2ob5A:
undetectable		 2zt7A-2ob5A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa2 POLYKETIDE OXYGENASE
CABE

(Streptomyces) 		PF01494
(FAD_binding_3) 		4 GLU A 231
ARG A 238
ARG A 223
GLU A 174
 None
 1.26A 2zt7A-2qa2A:
3.0		 2zt7A-2qa2A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 GLU A 927
ARG A 926
ARG A1068
GLU A1089
 None
 1.04A 2zt7A-2vdcA:
undetectable		 2zt7A-2vdcA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 GLU A 872
GLU A 874
TYR A 856
ARG A 731
 None
 1.26A 2zt7A-2vsqA:
undetectable		 2zt7A-2vsqA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TYR A 210
ARG A 174
GLU A 458
SER A 370
 None
None
GOL  A1726 ( 4.7A)
GOL  A1726 (-3.4A)
 1.22A 2zt7A-2x40A:
undetectable		 2zt7A-2x40A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvp MUTT/NUDIX FAMILY
PROTEIN

(Thermus
thermophilus) 		PF00293
(NUDIX) 		4 GLU A 139
ARG A  62
GLU A  94
GLU A  90
 MG  A 183 (-2.5A)
RBY  A 186 (-3.2A)
MG  A 184 (-2.5A)
MG  A 183 (-2.6A)
 1.27A 2zt7A-2yvpA:
undetectable		 2zt7A-2yvpA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like) 		4 TYR A 193
ARG A 157
GLU A 590
SER A 356
 None
None
GOL  A5001 ( 4.6A)
GOL  A5001 (-3.5A)
 1.24A 2zt7A-3abzA:
undetectable		 2zt7A-3abzA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcn ERVATAMIN-A

(Tabernaemontana
divaricata) 		PF00112
(Peptidase_C1) 		4 GLU A  35
ARG A 172
GLU A  50
GLU A  84
 None
 1.26A 2zt7A-3bcnA:
undetectable		 2zt7A-3bcnA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beo UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Bacillus
anthracis) 		PF02350
(Epimerase_2) 		4 GLU A 136
ARG A 140
GLU A 212
SER A 132
 UD1  A 372 (-3.6A)
None
None
None
 1.24A 2zt7A-3beoA:
2.3		 2zt7A-3beoA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl6 5'-METHYLTHIOADENOSI
NE
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE

(Staphylococcus
aureus) 		PF01048
(PNP_UDP_1) 		4 GLU A 173
ARG A 192
GLU A 171
SER A 146
 FMC  A 229 (-2.5A)
FMC  A 229 (-3.7A)
FMC  A 229 (-4.7A)
None
 1.16A 2zt7A-3bl6A:
undetectable		 2zt7A-3bl6A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clm TRANSALDOLASE

(Neisseria
gonorrhoeae) 		PF00923
(TAL_FSA) 		4 GLU A  76
ARG A 125
GLU A 122
SER A 109
 EDO  A 360 (-4.8A)
None
None
None
 1.12A 2zt7A-3clmA:
undetectable		 2zt7A-3clmA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Bacillus
halodurans) 		PF01266
(DAO)
PF16901
(DAO_C) 		4 GLU A 482
ARG A 171
GLU A 175
SER A 406
 None
 0.54A 2zt7A-3da1A:
1.5		 2zt7A-3da1A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ee4 PROBABLE
RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		4 GLU A 202
GLU A 101
TYR A 175
GLU A  68
 FE  A 317 ( 2.6A)
FE  A 317 (-2.5A)
None
MN3  A 316 ( 2.4A)
 1.25A 2zt7A-3ee4A:
undetectable		 2zt7A-3ee4A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE

(Neisseria
meningitidis) 		PF01048
(PNP_UDP_1) 		4 GLU A 178
ARG A 197
GLU A 176
SER A 151
 MTM  A 234 (-2.6A)
MTM  A 234 (-3.6A)
MTM  A 234 (-4.6A)
None
 1.14A 2zt7A-3eeiA:
3.1		 2zt7A-3eeiA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG

(Homo sapiens) 		PF09445
(Methyltransf_15) 		4 ARG A 848
GLU A 825
GLU A 827
SER A 656
 None
 1.10A 2zt7A-3egiA:
undetectable		 2zt7A-3egiA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN

(Bos taurus) 		PF03055
(RPE65) 		4 GLU A 462
TYR A 501
ARG A 515
GLU A 512
 None
 1.14A 2zt7A-3fsnA:
undetectable		 2zt7A-3fsnA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gir AMINOMETHYLTRANSFERA
SE

(Bartonella
henselae) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 ARG A 102
TYR A 272
ARG A 138
GLU A 134
 None
 1.20A 2zt7A-3girA:
undetectable		 2zt7A-3girA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmi UPF0348 PROTEIN
MJ0951

(Methanocaldococcus
jannaschii) 		PF05636
(HIGH_NTase1)
PF16581
(HIGH_NTase1_ass) 		4 GLU A  20
TYR A 101
ARG A 100
GLU A 117
 None
 1.22A 2zt7A-3gmiA:
undetectable		 2zt7A-3gmiA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 GLU B 139
ARG B 142
TYR B 362
ARG B 379
 None
 1.18A 2zt7A-3jcmB:
undetectable		 2zt7A-3jcmB:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermus
thermophilus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 GLU F 146
ARG F 116
GLU F 120
SER F  93
 MG  F 674 (-3.1A)
None
MG  F 674 (-2.0A)
None
 1.29A 2zt7A-3kfuF:
undetectable		 2zt7A-3kfuF:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgb THYMIDYLATE SYNTHASE
1/2

(Encephalitozoon
cuniculi) 		PF00303
(Thymidylat_synt) 		4 ARG A 148
GLU A 268
ARG A 119
GLU A 270
 None
 1.07A 2zt7A-3kgbA:
undetectable		 2zt7A-3kgbA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyq SYNAPTOBREVIN
HOMOLOG YKT6

(Rattus
norvegicus) 		PF00957
(Synaptobrevin)
PF13774
(Longin) 		4 GLU A  95
GLU A 145
TYR A  69
ARG A  56
 None
 1.04A 2zt7A-3kyqA:
undetectable		 2zt7A-3kyqA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg5 EPI-ISOZIZAENE
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 4 GLU A 175
ARG A 194
GLU A 253
TYR A 172
 MG  A 700 ( 3.9A)
POP  A 703 (-2.8A)
MG  A 700 ( 4.9A)
None
 0.97A 2zt7A-3lg5A:
undetectable		 2zt7A-3lg5A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER

(Pseudomonas
aeruginosa) 		PF12974
(Phosphonate-bd) 		4 GLU A 182
ARG A 205
GLU A  38
SER A  39
 None
 1.22A 2zt7A-3n5lA:
3.2		 2zt7A-3n5lA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4v MTA/SAH NUCLEOSIDASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		4 GLU A 174
ARG A 193
GLU A 172
SER A 147
 4CT  A 233 (-3.0A)
4CT  A 233 ( 4.7A)
None
None
 1.18A 2zt7A-3o4vA:
3.3		 2zt7A-3o4vA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odm PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Clostridium
perfringens) 		PF14010
(PEPcase_2) 		4 GLU A  44
ARG A 195
GLU A 119
SER A 118
 None
 1.01A 2zt7A-3odmA:
undetectable		 2zt7A-3odmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oum TOXOFLAVIN-DEGRADING
ENZYME

(Paenibacillus
polymyxa) 		PF00903
(Glyoxalase) 		4 GLU A 138
GLU A 113
ARG A 117
SER A 101
 MN  A 233 (-2.8A)
MN  A 233 ( 2.5A)
None
None
 1.15A 2zt7A-3oumA:
undetectable		 2zt7A-3oumA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT
PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli;
Escherichia
coli) 		PF01409
(tRNA-synt_2d)
PF02912
(Phe_tRNA-synt_N)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 ARG A 281
GLU B 459
ARG B 409
GLU B 458
 None
 0.93A 2zt7A-3pcoA:
13.1		 2zt7A-3pcoA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyq DEOXYRIBOSE-PHOSPHAT
E ALDOLASE, PUTATIVE

(Toxoplasma
gondii) 		no annotation 4 GLU A 105
ARG A 257
GLU A  20
SER A  50
 None
 1.16A 2zt7A-3qyqA:
undetectable		 2zt7A-3qyqA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6k ACETYLGLUTAMATE
KINASE

(Xanthomonas
campestris) 		PF00696
(AA_kinase)
PF04768
(NAT) 		4 GLU A 295
ARG A 293
GLU A 340
ARG A 343
 None
 1.24A 2zt7A-3s6kA:
2.7		 2zt7A-3s6kA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s83 GGDEF FAMILY PROTEIN

(Caulobacter
vibrioides) 		PF00563
(EAL) 		4 GLU A 503
GLU A 323
GLU A 416
SER A 382
 K  A 549 ( 4.7A)
K  A 549 (-3.4A)
K  A 549 (-3.8A)
None
 1.16A 2zt7A-3s83A:
undetectable		 2zt7A-3s83A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgi DNA LIGASE

(Mycobacterium
tuberculosis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB) 		4 GLU A  55
ARG A  62
GLU A  56
GLU A  52
 None
 1.29A 2zt7A-3sgiA:
undetectable		 2zt7A-3sgiA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssz MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Rhodobacteraceae
bacterium KLH11) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A 315
GLU A 263
ARG A 202
GLU A 237
 SO4  A 414 (-3.7A)
None
None
None
 1.11A 2zt7A-3sszA:
undetectable		 2zt7A-3sszA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tjz COATOMER SUBUNIT
GAMMA

(Bos taurus) 		PF01602
(Adaptin_N) 		4 ARG B 309
ARG B 234
GLU B 269
SER B 272
 None
 1.12A 2zt7A-3tjzB:
undetectable		 2zt7A-3tjzB:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2k DNA GYRASE SUBUNIT B

(Staphylococcus
aureus) 		PF02518
(HATPase_c) 		4 GLU A  68
ARG A 214
GLU A 224
SER A 226
 None
 1.18A 2zt7A-3u2kA:
undetectable		 2zt7A-3u2kA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Deinococcus
radiodurans) 		PF01063
(Aminotran_4) 		4 ARG A 100
TYR A 207
ARG A 192
GLU A 238
 PLP  A 371 (-3.0A)
COI  A1517 (-4.7A)
PLP  A 371 ( 3.7A)
PLP  A 371 (-3.7A)
 0.98A 2zt7A-3uzbA:
undetectable		 2zt7A-3uzbA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TYR A 204
ARG A 169
GLU A 441
SER A 384
 None
 1.23A 2zt7A-3zz1A:
undetectable		 2zt7A-3zz1A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmv SHORT-CHAIN
DEHYDROGENASE

(Sphingobium
yanoikuyae) 		PF00106
(adh_short) 		4 GLU A  22
ARG A  47
GLU A  51
SER A  52
 None
 1.04A 2zt7A-4bmvA:
undetectable		 2zt7A-4bmvA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e54 DNA DAMAGE-BINDING
PROTEIN 2

(Homo sapiens) 		PF00400
(WD40) 		4 GLU B  29
ARG B  25
GLU B  31
SER B  82
 None
 1.21A 2zt7A-4e54B:
undetectable		 2zt7A-4e54B:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqf PEX5-RELATED PROTEIN

(Mus musculus) 		PF13181
(TPR_8)
PF13432
(TPR_16) 		4 GLU A  69
ARG A 236
GLU A  67
SER A 280
 None
 1.25A 2zt7A-4eqfA:
undetectable		 2zt7A-4eqfA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Bacillus
subtilis) 		PF02350
(Epimerase_2) 		4 GLU A 134
ARG A 138
GLU A 210
SER A 130
 UD1  A 401 (-3.6A)
None
None
None
 1.28A 2zt7A-4fkzA:
2.1		 2zt7A-4fkzA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TYR A 248
ARG A 200
GLU A 509
SER A 451
 BGC  A 943 ( 4.5A)
BGC  A 942 (-3.8A)
BGC  A 942 (-3.1A)
BGC  A 942 (-3.4A)
 1.22A 2zt7A-4iigA:
undetectable		 2zt7A-4iigA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16

(Saccharomyces
cerevisiae) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		4 GLU A  37
TYR A 342
ARG A  87
GLU A  88
 None
 1.26A 2zt7A-4j7qA:
undetectable		 2zt7A-4j7qA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my0 GCN5-RELATED
N-ACETYLTRANSFERASE

(Kribbella
flavida) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 GLU A  90
ARG A  94
GLU A  58
SER A  55
 None
 1.21A 2zt7A-4my0A:
undetectable		 2zt7A-4my0A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2r ALPHA-L-ARABINOFURAN
OSIDASE UMABF62A

(Ustilago maydis) 		PF03664
(Glyco_hydro_62) 		4 GLU A 195
GLU A 213
TYR A 296
SER A 260
 AHR  A 403 (-2.8A)
None
None
None
 1.10A 2zt7A-4n2rA:
undetectable		 2zt7A-4n2rA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhy 2-OXOGLUTARATE AND
IRON-DEPENDENT
OXYGENASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF10637
(Ofd1_CTDD)
PF13661
(2OG-FeII_Oxy_4) 		4 GLU A 457
ARG A 505
TYR A 541
ARG A 255
 None
 1.20A 2zt7A-4nhyA:
undetectable		 2zt7A-4nhyA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qei GLYCINE--TRNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		6 GLU A 245
ARG A 277
GLU A 296
ARG A 410
GLU A 522
SER A 524
 None
AMP  A 701 (-2.9A)
None
None
None
AMP  A 701 (-3.2A)
 0.54A 2zt7A-4qeiA:
42.4		 2zt7A-4qeiA:
99.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7k HYPOTHETICAL PROTEIN
JHP0584

(Helicobacter
pylori) 		no annotation 4 GLU A 104
TYR A  59
ARG A  71
GLU A  82
 None
None
None
CME  A  73 ( 3.5A)
 1.26A 2zt7A-4r7kA:
undetectable		 2zt7A-4r7kA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 GLU A1957
TYR A1897
ARG A1900
SER A1904
 None
 1.19A 2zt7A-4r7yA:
undetectable		 2zt7A-4r7yA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rc6 ALDEHYDE
DECARBONYLASE

(Synechococcus
elongatus) 		PF11266
(Ald_deCOase) 		4 GLU B  60
GLU B 144
TYR B  39
GLU B 115
 FE2  B 301 ( 2.3A)
FE2  B 302 ( 2.4A)
None
FE2  B 301 (-2.0A)
 1.10A 2zt7A-4rc6B:
undetectable		 2zt7A-4rc6B:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tps SPORULATION
INHIBITOR OF
REPLICATION PROTEIN
SIRA
CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Bacillus
subtilis;
Bacillus
subtilis) 		PF10747
(SirA)
PF11638
(DnaA_N) 		4 ARG A  21
ARG B  51
GLU B  55
SER B  56
 None
 1.15A 2zt7A-4tpsA:
undetectable		 2zt7A-4tpsA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umi FIBER PROTEIN

(Snake
atadenovirus A) 		no annotation 4 GLU A 264
ARG A 271
GLU A 262
SER A 241
 None
 1.11A 2zt7A-4umiA:
undetectable		 2zt7A-4umiA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x7m TARM

(Staphylococcus
aureus) 		PF00534
(Glycos_transf_1) 		4 TYR A 122
ARG A 110
GLU A 104
SER A 105
 None
 1.24A 2zt7A-4x7mA:
3.3		 2zt7A-4x7mA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zb1 BLUE CHROMOPROTEIN,
SGBP

(Stichodactyla
gigantea) 		PF01353
(GFP) 		4 TYR A 177
ARG A 146
GLU A 144
SER A 157
 None
None
CRQ  A  62 ( 3.5A)
CRQ  A  62 ( 2.5A)
 1.27A 2zt7A-4zb1A:
undetectable		 2zt7A-4zb1A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zck GTP-BINDING PROTEIN
TYPA/BIPA

(Escherichia
coli) 		PF00679
(EFG_C) 		4 GLU A 570
GLU A 566
ARG A 422
SER A 453
 None
 1.20A 2zt7A-4zckA:
undetectable		 2zt7A-4zckA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLU A 514
TYR A 487
ARG A 481
GLU A 511
 None
 1.29A 2zt7A-4zo6A:
2.1		 2zt7A-4zo6A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdi CHAPERONIN 60B1

(Chlamydomonas
reinhardtii) 		PF00118
(Cpn60_TCP1) 		4 GLU A 368
GLU A 364
TYR A 289
ARG A 285
 None
 1.25A 2zt7A-5cdiA:
2.7		 2zt7A-5cdiA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 ARG A 718
GLU A 696
GLU A 635
SER A 723
 None
 1.06A 2zt7A-5dotA:
2.8		 2zt7A-5dotA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e59 FRNE PROTEIN

(Deinococcus
radiodurans) 		PF01323
(DSBA) 		4 GLU A 130
ARG A 131
TYR A  26
ARG A  30
 None
 1.10A 2zt7A-5e59A:
undetectable		 2zt7A-5e59A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eix DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A

(Klebsiella
pneumoniae) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 GLU A1464
ARG A1361
GLU A1135
SER A1134
 None
 1.23A 2zt7A-5eixA:
undetectable		 2zt7A-5eixA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TYR A 249
ARG A 201
GLU A 510
SER A 452
 None
None
EDO  A1872 ( 4.9A)
EDO  A1881 ( 3.8A)
 1.21A 2zt7A-5fjiA:
2.8		 2zt7A-5fjiA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TYR A 249
ARG A 201
GLU A 510
SER A 452
 None
None
None
PEG  A6002 ( 4.5A)
 1.16A 2zt7A-5fjjA:
2.9		 2zt7A-5fjjA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g49 NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT B-6
NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT C-3

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF00808
(CBFD_NFYB_HMF)
PF00808
(CBFD_NFYB_HMF) 		4 GLU A 120
ARG A 146
GLU B  92
SER B  90
 None
 1.15A 2zt7A-5g49A:
undetectable		 2zt7A-5g49A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gne LEUCINE
AMINOPEPTIDASE

(Legionella
pneumophila) 		PF04389
(Peptidase_M28) 		4 GLU A 261
GLU A 260
ARG A  74
SER A 338
 ZN  A 401 (-2.6A)
ZN  A 402 ( 3.7A)
ZN  A 401 ( 3.7A)
ZN  A 402 ( 4.8A)
 1.13A 2zt7A-5gneA:
undetectable		 2zt7A-5gneA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqt NITRILE-SPECIFIER
PROTEIN 1

(Arabidopsis
thaliana) 		PF01344
(Kelch_1)
PF01419
(Jacalin)
PF13415
(Kelch_3) 		4 ARG A 292
GLU A 341
GLU A 386
SER A 369
 None
 1.04A 2zt7A-5gqtA:
undetectable		 2zt7A-5gqtA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44

(Homo sapiens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		4 GLU A 229
ARG A 372
ARG A  95
GLU A  93
 None
 1.24A 2zt7A-5gu6A:
2.5		 2zt7A-5gu6A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7w VENOM
5'-NUCLEOTIDASE

(Naja atra) 		no annotation 4 GLU A 196
ARG A 228
GLU A 225
SER A 221
 None
 1.26A 2zt7A-5h7wA:
undetectable		 2zt7A-5h7wA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 GLU A1501
ARG A1167
GLU A1162
SER A1522
 None
 1.08A 2zt7A-5i6hA:
undetectable		 2zt7A-5i6hA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5id6 CPF1

(Lachnospiraceae
bacterium
ND2006) 		no annotation 4 TYR A 487
ARG A 482
GLU A 479
SER A 394
 None
 1.14A 2zt7A-5id6A:
undetectable		 2zt7A-5id6A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TYR A 245
ARG A 200
GLU A 505
SER A 447
 BGC  A 946 (-4.7A)
BGC  A 946 (-3.9A)
BGC  A 946 (-3.3A)
BGC  A 946 (-3.5A)
 1.24A 2zt7A-5ju6A:
undetectable		 2zt7A-5ju6A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 TYR A 175
ARG A 176
GLU A 361
SER A 257
 None
FAD  A 401 (-3.9A)
K  A 402 (-4.2A)
None
 1.28A 2zt7A-5jzxA:
undetectable		 2zt7A-5jzxA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE

(Helicobacter
pylori) 		PF01048
(PNP_UDP_1) 		4 GLU A 175
ARG A 194
GLU A 173
SER A 149
 4CT  A 301 (-2.2A)
4CT  A 301 ( 4.2A)
None
None
 1.23A 2zt7A-5k1zA:
undetectable		 2zt7A-5k1zA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k52 ALDEHYDE
DECARBONYLASE

(Limnothrix sp.
KNUA012) 		PF11266
(Ald_deCOase) 		4 GLU A  32
GLU A  60
TYR A 122
GLU A 144
 OCD  A 500 (-3.5A)
OCD  A 500 (-3.2A)
None
OCD  A 500 (-3.0A)
 1.15A 2zt7A-5k52A:
undetectable		 2zt7A-5k52A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mb9 PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		4 GLU A  41
GLU A 144
TYR A  60
ARG A 137
 None
 0.91A 2zt7A-5mb9A:
undetectable		 2zt7A-5mb9A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 4 TYR A 244
ARG A 196
GLU A 505
SER A 446
 None
 1.19A 2zt7A-5nbsA:
undetectable		 2zt7A-5nbsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01063
(Aminotran_4) 		4 ARG A 101
TYR A 209
ARG A 194
GLU A 240
 7TS  A 400 (-2.7A)
7TS  A 400 (-4.3A)
7TS  A 400 (-3.6A)
7TS  A 400 (-3.3A)
 1.02A 2zt7A-5u3fA:
undetectable		 2zt7A-5u3fA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 4 GLU A 666
TYR A 243
ARG A 215
SER A 662
 None
 0.90A 2zt7A-5xqoA:
undetectable		 2zt7A-5xqoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE

(Saccharomyces
cerevisiae) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		4 GLU A 790
ARG A 779
ARG A 838
GLU A 834
 None
 1.15A 2zt7A-5xvmA:
2.3		 2zt7A-5xvmA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus) 		no annotation 4 GLU A 462
ARG A 457
GLU A 386
SER A 354
 None
 1.17A 2zt7A-5ybbA:
undetectable		 2zt7A-5ybbA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE

(Escherichia
coli) 		no annotation 4 GLU A  68
ARG A  40
TYR A  62
ARG A 345
 None
 1.28A 2zt7A-6bqcA:
undetectable		 2zt7A-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Moorella
thermoacetica) 		no annotation 4 GLU A 279
TYR A 256
ARG A 301
SER A 143
 None
 0.96A 2zt7A-6cipA:
undetectable		 2zt7A-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epd PROTEASOME SUBUNIT
BETA TYPE-4

(Rattus
norvegicus) 		no annotation 4 GLU 7 196
ARG 7 195
GLU 7 211
TYR 7 188
 None
 1.00A 2zt7A-6epd7:
undetectable		 2zt7A-6epd7:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fbt LYTIC MUREIN
TRANSGLYCOSYLASE

(Pseudomonas
aeruginosa) 		no annotation 4 GLU A  81
ARG A  84
ARG A  73
GLU A  69
 None
 1.12A 2zt7A-6fbtA:
2.3		 2zt7A-6fbtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gru ADP-SUGAR
PYROPHOSPHATASE

(Homo sapiens) 		no annotation 4 GLU A 166
ARG A  84
GLU A 116
GLU A 112
 MG  A 302 ( 2.5A)
MG  A 301 ( 4.5A)
MG  A 301 ( 2.5A)
MG  A 302 (-2.5A)
 1.28A 2zt7A-6gruA:
undetectable		 2zt7A-6gruA:
undetectable