SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZSE_A_PAUA600
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b3b | PROTEIN (GLUTAMATEDEHYDROGENASE) (Thermotogamaritima) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 4 | TYR A 155PHE A 126PHE A 41ILE A 71 | None | 1.19A | 2zseA-1b3bA:0.0 | 2zseA-1b3bA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bsf | THYMIDYLATE SYNTHASEA (Bacillussubtilis) |
PF00303(Thymidylat_synt) | 4 | TYR A 8PHE A 275ILE A 12ASN A 9 | None | 1.10A | 2zseA-1bsfA:0.0 | 2zseA-1bsfA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gyc | LACCASE 2 (Trametesversicolor) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | PHE A 198PHE A 246ILE A 188ASN A 172 | None | 1.24A | 2zseA-1gycA:undetectable | 2zseA-1gycA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hxj | BETA-GLUCOSIDASE (Zea mays) |
PF00232(Glyco_hydro_1) | 4 | TYR A 449PHE A 25MET A 87ILE A 433 | None | 1.22A | 2zseA-1hxjA:0.0 | 2zseA-1hxjA:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jd0 | CARBONIC ANHYDRASEXII (Homo sapiens) |
PF00194(Carb_anhydrase) | 4 | TYR A 51PHE A 49PHE A 212ILE A 79 | None | 1.15A | 2zseA-1jd0A:undetectable | 2zseA-1jd0A:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jdp | ATRIAL NATRIURETICPEPTIDE CLEARANCERECEPTOR (Homo sapiens) |
PF01094(ANF_receptor) | 4 | TYR A 189PHE A 191ILE A 202ASN A 205 | None | 1.25A | 2zseA-1jdpA:0.7 | 2zseA-1jdpA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kfi | PHOSPHOGLUCOMUTASE 1 (Parameciumtetraurelia) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 4 | TYR A 473PHE A 474PHE A 506ILE A 556 | None | 1.22A | 2zseA-1kfiA:0.0 | 2zseA-1kfiA:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l9w | 3-DEHYDROQUINATEDEHYDRATASE AROD (Salmonellaenterica) |
PF01487(DHquinase_I) | 4 | ARG A 25PHE A 52ILE A 27ASN A 28 | None | 1.07A | 2zseA-1l9wA:0.0 | 2zseA-1l9wA:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rro | RAT ONCOMODULIN (Rattus rattus) |
PF13499(EF-hand_7) | 4 | PHE A 102MET A 105PHE A 30ILE A 50 | None | 0.82A | 2zseA-1rroA:undetectable | 2zseA-1rroA:17.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sjw | NOGALONIC ACIDMETHYL ESTER CYCLASE (Streptomycesnogalater) |
PF07366(SnoaL) | 4 | TYR A 31PHE A 48PHE A 15ILE A 116 | NoneNoneNGV A 333 ( 4.4A)None | 1.01A | 2zseA-1sjwA:0.0 | 2zseA-1sjwA:19.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1sq5 | PANTOTHENATE KINASE (Escherichiacoli) |
PF00485(PRK) | 4 | TYR A1240PHE A1244PHE A1259ASN A1282 | PAU A6001 (-4.3A)NoneNonePAU A6001 (-3.0A) | 0.65A | 2zseA-1sq5A:37.2 | 2zseA-1sq5A:52.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u2z | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-79SPECIFIC (Saccharomycescerevisiae) |
PF08123(DOT1) | 4 | PHE A 308PHE A 255ILE A 312ASN A 313 | None | 1.17A | 2zseA-1u2zA:undetectable | 2zseA-1u2zA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u53 | SECRETED PROTEINASP-2 (Necatoramericanus) |
PF00188(CAP) | 4 | TYR A 153PHE A 67ILE A 82ASN A 61 | None | 1.04A | 2zseA-1u53A:undetectable | 2zseA-1u53A:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ujs | ACTIN-BINDING LIMPROTEIN HOMOLOGUE (Homo sapiens) |
PF02209(VHP)PF16182(AbLIM_anchor) | 4 | PHE A 57MET A 59PHE A 53ASN A 73 | None | 1.23A | 2zseA-1ujsA:undetectable | 2zseA-1ujsA:15.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vjs | ALPHA-AMYLASE (Bacilluslicheniformis) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 4 | PHE A 160PHE A 141ILE A 201ASN A 104 | None | 1.20A | 2zseA-1vjsA:undetectable | 2zseA-1vjsA:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vpb | PUTATIVE MODULATOROF DNA GYRASE (Bacteroidesthetaiotaomicron) |
PF01523(PmbA_TldD) | 4 | TYR A 106ARG A 105ILE A 165ASN A 167 | None | 1.02A | 2zseA-1vpbA:undetectable | 2zseA-1vpbA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w61 | B-CELL MITOGEN (Trypanosomacruzi) |
PF05544(Pro_racemase) | 4 | ARG A 59PHE A 46MET A 377PHE A 379 | None | 0.99A | 2zseA-1w61A:undetectable | 2zseA-1w61A:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wkb | LEUCYL-TRNASYNTHETASE (Pyrococcushorikoshii) |
PF00133(tRNA-synt_1)PF08264(Anticodon_1) | 4 | ARG A 607PHE A 76ILE A 59ASN A 641 | None | 1.19A | 2zseA-1wkbA:undetectable | 2zseA-1wkbA:17.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zgj | ISOFLAVANONE4'-O-METHYLTRANSFERASE' (Medicagotruncatula) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 4 | ARG A 76PHE A 74ILE A 70ASN A 69 | None | 0.94A | 2zseA-1zgjA:2.4 | 2zseA-1zgjA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zsw | GLYOXALASE FAMILYPROTEIN (Bacillus cereus) |
PF00903(Glyoxalase) | 4 | TYR A 180PHE A 178PHE A 261ILE A 4 | None | 0.99A | 2zseA-1zswA:undetectable | 2zseA-1zswA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gvk | HEME PEROXIDASE (Bacteroidesthetaiotaomicron) |
PF04261(Dyp_perox) | 4 | ARG A 56PHE A 123PHE A 48ILE A 112 | None | 1.24A | 2zseA-2gvkA:undetectable | 2zseA-2gvkA:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hzs | RNA POLYMERASE IIMEDIATOR COMPLEXSUBUNIT 18RNA POLYMERASE IIMEDIATOR COMPLEXSUBUNIT 8 (Saccharomycescerevisiae;Saccharomycescerevisiae) |
PF09637(Med18)no annotation | 4 | MET B 296PHE I 206ILE B 185ASN B 258 | None | 1.04A | 2zseA-2hzsB:undetectable | 2zseA-2hzsB:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i0x | HYPOTHETICAL PROTEINPF1117 (Pyrococcusfuriosus) |
PF09827(CRISPR_Cas2) | 4 | ARG A 22PHE A 20MET A 23ILE A 52 | None | 1.21A | 2zseA-2i0xA:undetectable | 2zseA-2i0xA:13.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2if2 | DEPHOSPHO-COA KINASE (Aquifexaeolicus) |
PF01121(CoaE) | 4 | TYR A 27ARG A 22PHE A 108ILE A 98 | None | 1.22A | 2zseA-2if2A:7.9 | 2zseA-2if2A:17.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kr0 | PROTEASOMALUBIQUITIN RECEPTORADRM1 (Homo sapiens) |
PF04683(Proteasom_Rpn13)PF16550(RPN13_C) | 4 | ARG A 309PHE A 343ILE A 300ASN A 303 | None | 1.03A | 2zseA-2kr0A:undetectable | 2zseA-2kr0A:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2n53 | MAJOR PRION PROTEIN (Ovis aries) |
PF00377(Prion) | 4 | TYR A 153ARG A 154ILE A 142ASN A 162 | None | 1.24A | 2zseA-2n53A:undetectable | 2zseA-2n53A:16.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2odt | INOSITOL-TETRAKISPHOSPHATE 1-KINASE (Homo sapiens) |
PF05770(Ins134_P3_kin) | 4 | ARG X 32PHE X 27PHE X 24ILE X 316 | None | 1.13A | 2zseA-2odtX:undetectable | 2zseA-2odtX:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pg6 | CYTOCHROME P450 2A6 (Homo sapiens) |
PF00067(p450) | 4 | ARG A 101PHE A 107PHE A 480ILE A 300 | HEM A 500 (-2.6A)NoneNoneNone | 0.90A | 2zseA-2pg6A:undetectable | 2zseA-2pg6A:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qt6 | LACCASE (Lentinustigrinus) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | PHE A 198PHE A 246ILE A 188ASN A 172 | None | 1.25A | 2zseA-2qt6A:undetectable | 2zseA-2qt6A:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rb5 | PUTATIVEUNCHARACTERIZEDPROTEIN (Bacteroidesthetaiotaomicron) |
PF08282(Hydrolase_3) | 4 | TYR A 126PHE A 125PHE A 153ILE A 134 | None | 1.05A | 2zseA-2rb5A:undetectable | 2zseA-2rb5A:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rdl | CHYMASE 2 (Mesocricetusauratus) |
PF00089(Trypsin) | 4 | MET A 53PHE A 45ILE A 208ASN A 128 | None | 1.15A | 2zseA-2rdlA:undetectable | 2zseA-2rdlA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ro1 | TRANSCRIPTIONINTERMEDIARY FACTOR1-BETA (Homo sapiens) |
PF00628(PHD) | 4 | TYR A 755PHE A 761PHE A 792ILE A 743 | None | 1.10A | 2zseA-2ro1A:undetectable | 2zseA-2ro1A:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w8q | SUCCINATE-SEMIALDEHYDE DEHYDROGENASE,MITOCHONDRIAL (Homo sapiens) |
PF00171(Aldedh) | 4 | TYR A 128PHE A 162ILE A 132ASN A 129 | None | 1.09A | 2zseA-2w8qA:undetectable | 2zseA-2w8qA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wjr | PROBABLEN-ACETYLNEURAMINICACID OUTER MEMBRANECHANNEL PROTEIN NANC (Escherichiacoli) |
PF06178(KdgM) | 4 | TYR A 187ARG A 208PHE A 171ASN A 205 | None | 1.23A | 2zseA-2wjrA:undetectable | 2zseA-2wjrA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z69 | DNR PROTEIN (Pseudomonasaeruginosa) |
PF00027(cNMP_binding) | 4 | ARG A 110PHE A 109PHE A 3ILE A 57 | None | 0.84A | 2zseA-2z69A:undetectable | 2zseA-2z69A:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a0x | SENSOR PROTEIN (Thermotogamaritima) |
PF02518(HATPase_c) | 4 | PHE A 744PHE A 703ILE A 694ASN A 737 | None | 1.24A | 2zseA-3a0xA:undetectable | 2zseA-3a0xA:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a28 | L-2.3-BUTANEDIOLDEHYDROGENASE (Corynebacteriumglutamicum) |
no annotation | 4 | ARG C 125PHE C 127PHE C 82ILE C 136 | None | 1.08A | 2zseA-3a28C:undetectable | 2zseA-3a28C:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ahx | BETA-GLUCOSIDASE A (Clostridiumcellulovorans) |
PF00232(Glyco_hydro_1) | 4 | ARG A 5PHE A 6PHE A 12ILE A 387 | None | 1.09A | 2zseA-3ahxA:undetectable | 2zseA-3ahxA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3akz | GLUTAMYL-TRNASYNTHETASE 2 (Thermotogamaritima) |
no annotation | 4 | PHE B 47MET B 50PHE B 303ILE B 244 | None | 0.89A | 2zseA-3akzB:undetectable | 2zseA-3akzB:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3btu | GALACTOSE/LACTOSEMETABOLISMREGULATORY PROTEINGAL80 (Saccharomycescerevisiae) |
PF01408(GFO_IDH_MocA) | 4 | ARG A 153PHE A 399PHE A 389ILE A 147 | None | 1.04A | 2zseA-3btuA:undetectable | 2zseA-3btuA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cjw | COUP TRANSCRIPTIONFACTOR 2 (Homo sapiens) |
PF00104(Hormone_recep) | 4 | PHE A 382PHE A 253ILE A 212ASN A 211 | None | 1.06A | 2zseA-3cjwA:undetectable | 2zseA-3cjwA:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dka | DINB-LIKE PROTEIN (Bacillussubtilis) |
PF05163(DinB) | 4 | PHE A 11MET A 125PHE A 52ASN A 5 | None | 1.22A | 2zseA-3dkaA:undetectable | 2zseA-3dkaA:18.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ehm | SUSD HOMOLOG (Bacteroidesthetaiotaomicron) |
PF12741(SusD-like) | 4 | PHE A 489MET A 500PHE A 155ASN A 87 | None | 1.01A | 2zseA-3ehmA:undetectable | 2zseA-3ehmA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eup | TRANSCRIPTIONALREGULATOR, TETRFAMILY (Cytophagahutchinsonii) |
PF00440(TetR_N) | 4 | ARG A 9PHE A 13ILE A 14ASN A 49 | None | 1.15A | 2zseA-3eupA:undetectable | 2zseA-3eupA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g1n | E3 UBIQUITIN-PROTEINLIGASE HUWE1 (Homo sapiens) |
PF00632(HECT) | 4 | TYR A4133PHE A4128PHE A4074ILE A4251 | None | 1.05A | 2zseA-3g1nA:undetectable | 2zseA-3g1nA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gzs | UNCHARACTERIZED SUSDSUPERFAMILY PROTEIN (Bacteroidesfragilis) |
PF12741(SusD-like) | 4 | TYR A 385ARG A 449ILE A 389ASN A 386 | None | 1.25A | 2zseA-3gzsA:undetectable | 2zseA-3gzsA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h8w | RIBONUCLEASE H (Escherichiavirus T4) |
PF02739(5_3_exonuc_N)PF09293(RNaseH_C) | 4 | TYR A 121PHE A 305PHE A 290ILE A 51 | None | 1.13A | 2zseA-3h8wA:undetectable | 2zseA-3h8wA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hzr | TRYPTOPHANYL-TRNASYNTHETASE (Entamoebahistolytica) |
PF00579(tRNA-synt_1b) | 4 | TYR A 53PHE A 321PHE A 356ILE A 96 | None | 1.08A | 2zseA-3hzrA:undetectable | 2zseA-3hzrA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m70 | TELLURITE RESISTANCEPROTEIN TEHB HOMOLOG (Haemophilusinfluenzae) |
PF03848(TehB)PF09313(DUF1971) | 4 | PHE A 194PHE A 240ILE A 205ASN A 177 | None | 1.24A | 2zseA-3m70A:undetectable | 2zseA-3m70A:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mpn | TRANSPORTER (Aquifexaeolicus) |
PF00209(SNF) | 4 | ARG A 30PHE A 31PHE A 43ASN A 286 | NoneNoneNone NA A 752 (-2.9A) | 1.12A | 2zseA-3mpnA:undetectable | 2zseA-3mpnA:23.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3naf | CALCIUM-ACTIVATEDPOTASSIUM CHANNELSUBUNITALPHA-1,CALCIUM-ACTIVATED POTASSIUMCHANNEL SUBUNITALPHA-1,CALCIUM-ACTIVATED POTASSIUMCHANNEL SUBUNITALPHA-1 (Homo sapiens) |
PF03493(BK_channel_a) | 4 | TYR A 463ARG A 735MET A 739PHE A 692 | None | 1.15A | 2zseA-3nafA:undetectable | 2zseA-3nafA:17.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nzp | ARGININEDECARBOXYLASE (Campylobacterjejuni) |
PF02784(Orn_Arg_deC_N) | 4 | PHE A 513PHE A 444ILE A 462ASN A 459 | None | 1.16A | 2zseA-3nzpA:undetectable | 2zseA-3nzpA:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3owt | DNA-BINDING PROTEINRAP1 (Saccharomycescerevisiae) |
PF11626(Rap1_C) | 4 | TYR A 768PHE A 769PHE A 703ILE A 754 | None | 1.22A | 2zseA-3owtA:undetectable | 2zseA-3owtA:18.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3psf | TRANSCRIPTIONELONGATION FACTORSPT6 (Saccharomycescerevisiae) |
PF14635(HHH_7)PF14639(YqgF)PF14641(HTH_44)PF14878(DLD) | 4 | ARG A 882PHE A 776ILE A 777ASN A 771 | None | 1.17A | 2zseA-3psfA:undetectable | 2zseA-3psfA:15.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rp9 | MITOGEN-ACTIVATEDPROTEIN KINASE (Toxoplasmagondii) |
PF00069(Pkinase) | 4 | PHE A 435PHE A 129ILE A 103ASN A 107 | None | 1.03A | 2zseA-3rp9A:undetectable | 2zseA-3rp9A:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sag | EXOSOME COMPONENT 10 (Homo sapiens) |
PF00570(HRDC)PF01612(DNA_pol_A_exo1) | 4 | TYR A 382PHE A 198ILE A 202ASN A 353 | TYR A 382 ( 1.3A)PHE A 198 ( 1.3A)ILE A 202 ( 0.7A)ASN A 353 ( 0.6A) | 1.24A | 2zseA-3sagA:undetectable | 2zseA-3sagA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u4v | TELOMERASE-ASSOCIATED PROTEIN 82 (Tetrahymenathermophila) |
PF01336(tRNA_anti-codon) | 4 | TYR A 306PHE A 266PHE A 250ILE A 308 | None | 1.23A | 2zseA-3u4vA:undetectable | 2zseA-3u4vA:17.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vzh | PUTATIVEUNCHARACTERIZEDPROTEIN (Streptococcuspyogenes) |
PF09704(Cas_Cas5d) | 4 | TYR A 2ARG A 3PHE A 101PHE A 7 | None | 1.11A | 2zseA-3vzhA:undetectable | 2zseA-3vzhA:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wev | L-LYSINE 6-OXIDASE (Marinomonasmediterranea) |
no annotation | 4 | ARG A 650PHE A 251PHE A 513ILE A 56 | None | 1.24A | 2zseA-3wevA:undetectable | 2zseA-3wevA:18.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4amq | L544 (Acanthamoebapolyphagamimivirus) |
no annotation | 4 | ARG A 63PHE A 71ILE A 192ASN A 49 | None | 1.03A | 2zseA-4amqA:undetectable | 2zseA-4amqA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bjt | DNA-BINDING PROTEINRAP1 (Saccharomycescerevisiae) |
PF11626(Rap1_C) | 4 | TYR A 768PHE A 769PHE A 703ILE A 754 | None | 1.24A | 2zseA-4bjtA:undetectable | 2zseA-4bjtA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ezd | UREA TRANSPORTER 1 (Bos taurus) |
PF03253(UT) | 4 | TYR A 119PHE A 66PHE A 296ASN A 120 | SEY A 402 (-3.7A)SEY A 402 (-4.8A)NoneNone | 0.96A | 2zseA-4ezdA:undetectable | 2zseA-4ezdA:24.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f67 | UPF0176 PROTEINLPG2838 (Legionellapneumophila) |
PF00581(Rhodanese) | 4 | ARG A 64PHE A 59PHE A 49ILE A 25 | None | 1.25A | 2zseA-4f67A:undetectable | 2zseA-4f67A:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h2h | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (Salipigerbermudensis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | PHE A 206MET A 217PHE A 215ILE A 173 | None | 1.18A | 2zseA-4h2hA:undetectable | 2zseA-4h2hA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i3c | BILIRUBIN-INDUCIBLEFLUORESCENT PROTEINUNAG (Anguillajaponica) |
PF00061(Lipocalin) | 4 | TYR A 134ARG A 112PHE A 17ILE A 11 | NoneBLR A 200 (-3.6A)BLR A 200 (-3.6A)None | 1.25A | 2zseA-4i3cA:undetectable | 2zseA-4i3cA:17.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ieg | RNA-DEPENDENT RNAPOLYMERASE P2 (Pseudomonasphage phi12) |
no annotation | 4 | PHE A 646MET A 649PHE A 650ILE A 185 | None | 1.19A | 2zseA-4iegA:undetectable | 2zseA-4iegA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jhv | LACCASE (Coriolopsiscaperata) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | PHE A 197PHE A 245ILE A 187ASN A 171 | None | 1.23A | 2zseA-4jhvA:undetectable | 2zseA-4jhvA:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jqs | HYPOTHETICAL PROTEIN (Bacteroidesuniformis) |
PF06283(ThuA) | 4 | TYR A 109PHE A 106PHE A 137ILE A 90 | None | 1.25A | 2zseA-4jqsA:undetectable | 2zseA-4jqsA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4me3 | DNA REPLICATIONLICENSING FACTOR MCMRELATED PROTEIN (Thermoplasmaacidophilum) |
PF17207(MCM_OB) | 4 | ARG A 20PHE A 19ILE A 28ASN A 29 | None | 0.96A | 2zseA-4me3A:undetectable | 2zseA-4me3A:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ns4 | ALPHA/BETA HYDROLASEFOLD PROTEIN (Psychrobactercryohalolentis) |
PF00561(Abhydrolase_1) | 4 | ARG A 197MET A 174ILE A 270ASN A 56 | None | 1.23A | 2zseA-4ns4A:undetectable | 2zseA-4ns4A:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nz0 | GENOME POLYPROTEIN (Cardiovirus A) |
PF00680(RdRP_1) | 4 | TYR A 236PHE A 368ILE A 310ASN A 306 | None | 0.93A | 2zseA-4nz0A:undetectable | 2zseA-4nz0A:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o4o | PHYCOCYANOBILINLYASE CPCT (Nostoc sp. PCC7120) |
PF06206(CpeT) | 4 | PHE A 152PHE A 159ILE A 81ASN A 83 | None | 0.93A | 2zseA-4o4oA:undetectable | 2zseA-4o4oA:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4py6 | BROMODOMAIN PROTEIN,PUTATIVE (Plasmodiumfalciparum) |
PF00439(Bromodomain) | 4 | TYR A1257PHE A1263PHE A1298ILE A1248 | None | 1.17A | 2zseA-4py6A:undetectable | 2zseA-4py6A:16.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q9z | HUMAN PROTEIN KINASEC THETA (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 4 | ARG A 629PHE A 440ILE A 647ASN A 638 | None | 1.24A | 2zseA-4q9zA:undetectable | 2zseA-4q9zA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ue0 | FIBER (Bovineatadenovirus D) |
no annotation | 4 | MET A 430PHE A 432ILE A 512ASN A 513 | None | 1.14A | 2zseA-4ue0A:undetectable | 2zseA-4ue0A:15.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4up7 | LYSINE--TRNA LIGASE (Entamoebahistolytica) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 4 | ARG A 251PHE A 250ILE A 198ASN A 200 | LAD A1584 (-2.3A)NoneNoneNone | 1.23A | 2zseA-4up7A:undetectable | 2zseA-4up7A:16.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uw2 | CSM1 (Thermococcusonnurineus) |
PF01966(HD) | 4 | TYR A 626PHE A 600PHE A 604ILE A 770 | None | 1.22A | 2zseA-4uw2A:undetectable | 2zseA-4uw2A:17.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x57 | UBIQUITIN-CONJUGATING ENZYME E2 8 (Arabidopsisthaliana) |
PF00179(UQ_con) | 4 | ARG A 70PHE A 69ILE A 78ASN A 79 | None | 1.14A | 2zseA-4x57A:undetectable | 2zseA-4x57A:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xf5 | TWIN-ARGININETRANSLOCATIONPATHWAY SIGNAL (Chromohalobactersalexigens) |
PF03480(DctP) | 4 | PHE A 264PHE A 246ILE A 68ASN A 59 | None | 1.14A | 2zseA-4xf5A:undetectable | 2zseA-4xf5A:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ahv | ENTH DOMAIN OF EPSINENT1 (Saccharomycescerevisiae) |
PF01417(ENTH) | 4 | TYR E 82ARG E 85PHE E 86ILE E 40 | None | 0.92A | 2zseA-5ahvE:undetectable | 2zseA-5ahvE:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b3f | PHOSPHORIBULOKINASE/URIDINE KINASE (Methanospirillumhungatei) |
PF00485(PRK) | 4 | TYR A 221PHE A 223ILE A 315ASN A 319 | None | 0.98A | 2zseA-5b3fA:17.9 | 2zseA-5b3fA:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e43 | BETA-LACTAMASE (Streptosporangiumroseum) |
PF13354(Beta-lactamase2) | 4 | TYR A 265PHE A 153ILE A 248ASN A 246 | None | 1.23A | 2zseA-5e43A:undetectable | 2zseA-5e43A:24.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eeb | ALDEHYDEDEHYDROGENASE (Pyrobaculumferrireducens) |
PF00171(Aldedh) | 4 | PHE A 81MET A 84PHE A 88ILE A 114 | None | 1.11A | 2zseA-5eebA:undetectable | 2zseA-5eebA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eul | PROTEIN TRANSLOCASESUBUNIT SECY (Geobacillusthermodenitrificans) |
PF00344(SecY) | 4 | PHE Y 132MET Y 128ILE Y 58ASN Y 57 | None | 1.24A | 2zseA-5eulY:undetectable | 2zseA-5eulY:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f83 | BETA-LACTAMASE (Pseudomonasaeruginosa) |
PF13354(Beta-lactamase2) | 4 | TYR A 256PHE A 147ILE A 241ASN A 239 | None | 1.17A | 2zseA-5f83A:undetectable | 2zseA-5f83A:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f8u | BETA-1 ADRENERGICRECEPTOR (Meleagrisgallopavo) |
no annotation | 4 | ARG B 317PHE B 315ILE B 311ASN B 310 | NoneNoneNoneP32 B 400 (-3.5A) | 0.94A | 2zseA-5f8uB:undetectable | 2zseA-5f8uB:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hb3 | NUCLEOPORIN NIC96NUCLEOPORIN NUP53 (Chaetomiumthermophilum;Chaetomiumthermophilum) |
PF04097(Nic96)no annotation | 4 | PHE B 77PHE A 697ILE A 659ASN A 656 | None | 1.03A | 2zseA-5hb3B:undetectable | 2zseA-5hb3B:11.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kre | LYSOPHOSPHOLIPASE-LIKE PROTEIN 1 (Homo sapiens) |
PF02230(Abhydrolase_2) | 4 | TYR A 58PHE A 26PHE A 145ILE A 41 | None | 1.00A | 2zseA-5kreA:undetectable | 2zseA-5kreA:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lac | 3CL PROTEASE (Alphamesonivirus1) |
PF17222(Peptidase_C107) | 4 | TYR A 275PHE A 278PHE A 295ILE A 187 | None | 1.15A | 2zseA-5lacA:undetectable | 2zseA-5lacA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lp8 | E3 UBIQUITIN-PROTEINLIGASE HUWE1 (Homo sapiens) |
no annotation | 4 | TYR B4133PHE B4128PHE B4074ILE B4251 | None | 1.07A | 2zseA-5lp8B:undetectable | 2zseA-5lp8B:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lq3 | CMEB (Campylobacterjejuni) |
PF00873(ACR_tran) | 4 | PHE A 967PHE A 518ILE A1014ASN A 936 | None | 0.92A | 2zseA-5lq3A:undetectable | 2zseA-5lq3A:14.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m86 | TA1207 (Thermoplasmaacidophilum) |
no annotation | 4 | MET A 40PHE A 52ILE A 149ASN A 148 | None | 1.14A | 2zseA-5m86A:undetectable | 2zseA-5m86A:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5myf | DUTPASE FROM DI S.AUREUS PHAGE (Staphylococcusaureus) |
no annotation | 4 | PHE D 135PHE D 92ILE D 144ASN D 3 | None | 1.25A | 2zseA-5myfD:undetectable | 2zseA-5myfD:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ojq | HAEMOLYSINCO-REGULATED PROTEIN (Vibrio cholerae) |
PF05638(T6SS_HCP) | 4 | TYR 1 148PHE 1 68PHE 1 44ILE 1 151 | None | 1.23A | 2zseA-5ojq1:undetectable | 2zseA-5ojq1:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ulc | BROMODOMAIN PROTEIN1 (Plasmodiumfalciparum) |
PF00439(Bromodomain) | 4 | TYR X 392PHE X 398PHE X 430ILE X 383 | None | 1.23A | 2zseA-5ulcX:undetectable | 2zseA-5ulcX:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v8f | ORIGIN RECOGNITIONCOMPLEX SUBUNIT 5 (Saccharomycescerevisiae) |
PF13401(AAA_22)PF14630(ORC5_C) | 4 | TYR E 168PHE E 175ILE E 34ASN E 32 | None | 1.12A | 2zseA-5v8fE:undetectable | 2zseA-5v8fE:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vha | DEAH(ASP-GLU-ALA-HIS)BOX POLYPEPTIDE 36 (Bos taurus) |
no annotation | 4 | PHE A 714PHE A 915ILE A 986ASN A 829 | None | 1.23A | 2zseA-5vhaA:undetectable | 2zseA-5vhaA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xmb | PANTOTHENATE KINASE (Mycobacteriumtuberculosis) |
no annotation | 5 | TYR A 235PHE A 239MET A 242ILE A 272ASN A 277 | None | 0.55A | 2zseA-5xmbA:37.3 | 2zseA-5xmbA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xsy | SODIUM CHANNELPROTEINVOLTAGE-GATED SODIUMCHANNEL BETA SUBUNIT1 (Electrophoruselectricus;Electrophoruselectricus) |
PF00520(Ion_trans)PF06512(Na_trans_assoc)no annotation | 4 | TYR B 185ARG B 186ILE A 985ASN A 988 | None | 0.95A | 2zseA-5xsyB:undetectable | 2zseA-5xsyB:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6amn | HEAT SHOCK PROTEIN104 (Saccharomycescerevisiae) |
no annotation | 4 | TYR A 62PHE A 65PHE A 130ILE A 40 | None | 1.10A | 2zseA-6amnA:undetectable | 2zseA-6amnA:undetectable |