SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZSE_A_PAUA600

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3b PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermotoga
maritima) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 TYR A 155
PHE A 126
PHE A  41
ILE A  71
 None
 1.19A 2zseA-1b3bA:
0.0		 2zseA-1b3bA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsf THYMIDYLATE SYNTHASE
A

(Bacillus
subtilis) 		PF00303
(Thymidylat_synt) 		4 TYR A   8
PHE A 275
ILE A  12
ASN A   9
 None
 1.10A 2zseA-1bsfA:
0.0		 2zseA-1bsfA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PHE A 198
PHE A 246
ILE A 188
ASN A 172
 None
 1.24A 2zseA-1gycA:
undetectable		 2zseA-1gycA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays) 		PF00232
(Glyco_hydro_1) 		4 TYR A 449
PHE A  25
MET A  87
ILE A 433
 None
 1.22A 2zseA-1hxjA:
0.0		 2zseA-1hxjA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 TYR A  51
PHE A  49
PHE A 212
ILE A  79
 None
 1.15A 2zseA-1jd0A:
undetectable		 2zseA-1jd0A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdp ATRIAL NATRIURETIC
PEPTIDE CLEARANCE
RECEPTOR

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 TYR A 189
PHE A 191
ILE A 202
ASN A 205
 None
 1.25A 2zseA-1jdpA:
0.7		 2zseA-1jdpA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 TYR A 473
PHE A 474
PHE A 506
ILE A 556
 None
 1.22A 2zseA-1kfiA:
0.0		 2zseA-1kfiA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l9w 3-DEHYDROQUINATE
DEHYDRATASE AROD

(Salmonella
enterica) 		PF01487
(DHquinase_I) 		4 ARG A  25
PHE A  52
ILE A  27
ASN A  28
 None
 1.07A 2zseA-1l9wA:
0.0		 2zseA-1l9wA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rro RAT ONCOMODULIN

(Rattus rattus) 		PF13499
(EF-hand_7) 		4 PHE A 102
MET A 105
PHE A  30
ILE A  50
 None
 0.82A 2zseA-1rroA:
undetectable		 2zseA-1rroA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjw NOGALONIC ACID
METHYL ESTER CYCLASE

(Streptomyces
nogalater) 		PF07366
(SnoaL) 		4 TYR A  31
PHE A  48
PHE A  15
ILE A 116
 None
None
NGV  A 333 ( 4.4A)
None
 1.01A 2zseA-1sjwA:
0.0		 2zseA-1sjwA:
19.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sq5 PANTOTHENATE KINASE

(Escherichia
coli) 		PF00485
(PRK) 		4 TYR A1240
PHE A1244
PHE A1259
ASN A1282
 PAU  A6001 (-4.3A)
None
None
PAU  A6001 (-3.0A)
 0.65A 2zseA-1sq5A:
37.2		 2zseA-1sq5A:
52.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2z HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Saccharomyces
cerevisiae) 		PF08123
(DOT1) 		4 PHE A 308
PHE A 255
ILE A 312
ASN A 313
 None
 1.17A 2zseA-1u2zA:
undetectable		 2zseA-1u2zA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u53 SECRETED PROTEIN
ASP-2

(Necator
americanus) 		PF00188
(CAP) 		4 TYR A 153
PHE A  67
ILE A  82
ASN A  61
 None
 1.04A 2zseA-1u53A:
undetectable		 2zseA-1u53A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujs ACTIN-BINDING LIM
PROTEIN HOMOLOGUE

(Homo sapiens) 		PF02209
(VHP)
PF16182
(AbLIM_anchor) 		4 PHE A  57
MET A  59
PHE A  53
ASN A  73
 None
 1.23A 2zseA-1ujsA:
undetectable		 2zseA-1ujsA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjs ALPHA-AMYLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 PHE A 160
PHE A 141
ILE A 201
ASN A 104
 None
 1.20A 2zseA-1vjsA:
undetectable		 2zseA-1vjsA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpb PUTATIVE MODULATOR
OF DNA GYRASE

(Bacteroides
thetaiotaomicron) 		PF01523
(PmbA_TldD) 		4 TYR A 106
ARG A 105
ILE A 165
ASN A 167
 None
 1.02A 2zseA-1vpbA:
undetectable		 2zseA-1vpbA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w61 B-CELL MITOGEN

(Trypanosoma
cruzi) 		PF05544
(Pro_racemase) 		4 ARG A  59
PHE A  46
MET A 377
PHE A 379
 None
 0.99A 2zseA-1w61A:
undetectable		 2zseA-1w61A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkb LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 ARG A 607
PHE A  76
ILE A  59
ASN A 641
 None
 1.19A 2zseA-1wkbA:
undetectable		 2zseA-1wkbA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'

(Medicago
truncatula) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		4 ARG A  76
PHE A  74
ILE A  70
ASN A  69
 None
 0.94A 2zseA-1zgjA:
2.4		 2zseA-1zgjA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsw GLYOXALASE FAMILY
PROTEIN

(Bacillus cereus) 		PF00903
(Glyoxalase) 		4 TYR A 180
PHE A 178
PHE A 261
ILE A   4
 None
 0.99A 2zseA-1zswA:
undetectable		 2zseA-1zswA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gvk HEME PEROXIDASE

(Bacteroides
thetaiotaomicron) 		PF04261
(Dyp_perox) 		4 ARG A  56
PHE A 123
PHE A  48
ILE A 112
 None
 1.24A 2zseA-2gvkA:
undetectable		 2zseA-2gvkA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 18
RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 8

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF09637
(Med18)
no annotation 		4 MET B 296
PHE I 206
ILE B 185
ASN B 258
 None
 1.04A 2zseA-2hzsB:
undetectable		 2zseA-2hzsB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0x HYPOTHETICAL PROTEIN
PF1117

(Pyrococcus
furiosus) 		PF09827
(CRISPR_Cas2) 		4 ARG A  22
PHE A  20
MET A  23
ILE A  52
 None
 1.21A 2zseA-2i0xA:
undetectable		 2zseA-2i0xA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2if2 DEPHOSPHO-COA KINASE

(Aquifex
aeolicus) 		PF01121
(CoaE) 		4 TYR A  27
ARG A  22
PHE A 108
ILE A  98
 None
 1.22A 2zseA-2if2A:
7.9		 2zseA-2if2A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kr0 PROTEASOMAL
UBIQUITIN RECEPTOR
ADRM1

(Homo sapiens) 		PF04683
(Proteasom_Rpn13)
PF16550
(RPN13_C) 		4 ARG A 309
PHE A 343
ILE A 300
ASN A 303
 None
 1.03A 2zseA-2kr0A:
undetectable		 2zseA-2kr0A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n53 MAJOR PRION PROTEIN

(Ovis aries) 		PF00377
(Prion) 		4 TYR A 153
ARG A 154
ILE A 142
ASN A 162
 None
 1.24A 2zseA-2n53A:
undetectable		 2zseA-2n53A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odt INOSITOL-TETRAKISPHO
SPHATE 1-KINASE

(Homo sapiens) 		PF05770
(Ins134_P3_kin) 		4 ARG X  32
PHE X  27
PHE X  24
ILE X 316
 None
 1.13A 2zseA-2odtX:
undetectable		 2zseA-2odtX:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		4 ARG A 101
PHE A 107
PHE A 480
ILE A 300
 HEM  A 500 (-2.6A)
None
None
None
 0.90A 2zseA-2pg6A:
undetectable		 2zseA-2pg6A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PHE A 198
PHE A 246
ILE A 188
ASN A 172
 None
 1.25A 2zseA-2qt6A:
undetectable		 2zseA-2qt6A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF08282
(Hydrolase_3) 		4 TYR A 126
PHE A 125
PHE A 153
ILE A 134
 None
 1.05A 2zseA-2rb5A:
undetectable		 2zseA-2rb5A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdl CHYMASE 2

(Mesocricetus
auratus) 		PF00089
(Trypsin) 		4 MET A  53
PHE A  45
ILE A 208
ASN A 128
 None
 1.15A 2zseA-2rdlA:
undetectable		 2zseA-2rdlA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ro1 TRANSCRIPTION
INTERMEDIARY FACTOR
1-BETA

(Homo sapiens) 		PF00628
(PHD) 		4 TYR A 755
PHE A 761
PHE A 792
ILE A 743
 None
 1.10A 2zseA-2ro1A:
undetectable		 2zseA-2ro1A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		4 TYR A 128
PHE A 162
ILE A 132
ASN A 129
 None
 1.09A 2zseA-2w8qA:
undetectable		 2zseA-2w8qA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjr PROBABLE
N-ACETYLNEURAMINIC
ACID OUTER MEMBRANE
CHANNEL PROTEIN NANC

(Escherichia
coli) 		PF06178
(KdgM) 		4 TYR A 187
ARG A 208
PHE A 171
ASN A 205
 None
 1.23A 2zseA-2wjrA:
undetectable		 2zseA-2wjrA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z69 DNR PROTEIN

(Pseudomonas
aeruginosa) 		PF00027
(cNMP_binding) 		4 ARG A 110
PHE A 109
PHE A   3
ILE A  57
 None
 0.84A 2zseA-2z69A:
undetectable		 2zseA-2z69A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0x SENSOR PROTEIN

(Thermotoga
maritima) 		PF02518
(HATPase_c) 		4 PHE A 744
PHE A 703
ILE A 694
ASN A 737
 None
 1.24A 2zseA-3a0xA:
undetectable		 2zseA-3a0xA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum) 		no annotation 4 ARG C 125
PHE C 127
PHE C  82
ILE C 136
 None
 1.08A 2zseA-3a28C:
undetectable		 2zseA-3a28C:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahx BETA-GLUCOSIDASE A

(Clostridium
cellulovorans) 		PF00232
(Glyco_hydro_1) 		4 ARG A   5
PHE A   6
PHE A  12
ILE A 387
 None
 1.09A 2zseA-3ahxA:
undetectable		 2zseA-3ahxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akz GLUTAMYL-TRNA
SYNTHETASE 2

(Thermotoga
maritima) 		no annotation 4 PHE B  47
MET B  50
PHE B 303
ILE B 244
 None
 0.89A 2zseA-3akzB:
undetectable		 2zseA-3akzB:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btu GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80

(Saccharomyces
cerevisiae) 		PF01408
(GFO_IDH_MocA) 		4 ARG A 153
PHE A 399
PHE A 389
ILE A 147
 None
 1.04A 2zseA-3btuA:
undetectable		 2zseA-3btuA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjw COUP TRANSCRIPTION
FACTOR 2

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 PHE A 382
PHE A 253
ILE A 212
ASN A 211
 None
 1.06A 2zseA-3cjwA:
undetectable		 2zseA-3cjwA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dka DINB-LIKE PROTEIN

(Bacillus
subtilis) 		PF05163
(DinB) 		4 PHE A  11
MET A 125
PHE A  52
ASN A   5
 None
 1.22A 2zseA-3dkaA:
undetectable		 2zseA-3dkaA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehm SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 PHE A 489
MET A 500
PHE A 155
ASN A  87
 None
 1.01A 2zseA-3ehmA:
undetectable		 2zseA-3ehmA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eup TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Cytophaga
hutchinsonii) 		PF00440
(TetR_N) 		4 ARG A   9
PHE A  13
ILE A  14
ASN A  49
 None
 1.15A 2zseA-3eupA:
undetectable		 2zseA-3eupA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		PF00632
(HECT) 		4 TYR A4133
PHE A4128
PHE A4074
ILE A4251
 None
 1.05A 2zseA-3g1nA:
undetectable		 2zseA-3g1nA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis) 		PF12741
(SusD-like) 		4 TYR A 385
ARG A 449
ILE A 389
ASN A 386
 None
 1.25A 2zseA-3gzsA:
undetectable		 2zseA-3gzsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8w RIBONUCLEASE H

(Escherichia
virus T4) 		PF02739
(5_3_exonuc_N)
PF09293
(RNaseH_C) 		4 TYR A 121
PHE A 305
PHE A 290
ILE A  51
 None
 1.13A 2zseA-3h8wA:
undetectable		 2zseA-3h8wA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzr TRYPTOPHANYL-TRNA
SYNTHETASE

(Entamoeba
histolytica) 		PF00579
(tRNA-synt_1b) 		4 TYR A  53
PHE A 321
PHE A 356
ILE A  96
 None
 1.08A 2zseA-3hzrA:
undetectable		 2zseA-3hzrA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m70 TELLURITE RESISTANCE
PROTEIN TEHB HOMOLOG

(Haemophilus
influenzae) 		PF03848
(TehB)
PF09313
(DUF1971) 		4 PHE A 194
PHE A 240
ILE A 205
ASN A 177
 None
 1.24A 2zseA-3m70A:
undetectable		 2zseA-3m70A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		4 ARG A  30
PHE A  31
PHE A  43
ASN A 286
 None
None
None
NA  A 752 (-2.9A)
 1.12A 2zseA-3mpnA:
undetectable		 2zseA-3mpnA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naf CALCIUM-ACTIVATED
POTASSIUM CHANNEL
SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1

(Homo sapiens) 		PF03493
(BK_channel_a) 		4 TYR A 463
ARG A 735
MET A 739
PHE A 692
 None
 1.15A 2zseA-3nafA:
undetectable		 2zseA-3nafA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzp ARGININE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF02784
(Orn_Arg_deC_N) 		4 PHE A 513
PHE A 444
ILE A 462
ASN A 459
 None
 1.16A 2zseA-3nzpA:
undetectable		 2zseA-3nzpA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owt DNA-BINDING PROTEIN
RAP1

(Saccharomyces
cerevisiae) 		PF11626
(Rap1_C) 		4 TYR A 768
PHE A 769
PHE A 703
ILE A 754
 None
 1.22A 2zseA-3owtA:
undetectable		 2zseA-3owtA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		4 ARG A 882
PHE A 776
ILE A 777
ASN A 771
 None
 1.17A 2zseA-3psfA:
undetectable		 2zseA-3psfA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp9 MITOGEN-ACTIVATED
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 PHE A 435
PHE A 129
ILE A 103
ASN A 107
 None
 1.03A 2zseA-3rp9A:
undetectable		 2zseA-3rp9A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sag EXOSOME COMPONENT 10

(Homo sapiens) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		4 TYR A 382
PHE A 198
ILE A 202
ASN A 353
 TYR  A 382 ( 1.3A)
PHE  A 198 ( 1.3A)
ILE  A 202 ( 0.7A)
ASN  A 353 ( 0.6A)
 1.24A 2zseA-3sagA:
undetectable		 2zseA-3sagA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4v TELOMERASE-ASSOCIATE
D PROTEIN 82

(Tetrahymena
thermophila) 		PF01336
(tRNA_anti-codon) 		4 TYR A 306
PHE A 266
PHE A 250
ILE A 308
 None
 1.23A 2zseA-3u4vA:
undetectable		 2zseA-3u4vA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzh PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pyogenes) 		PF09704
(Cas_Cas5d) 		4 TYR A   2
ARG A   3
PHE A 101
PHE A   7
 None
 1.11A 2zseA-3vzhA:
undetectable		 2zseA-3vzhA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wev L-LYSINE 6-OXIDASE

(Marinomonas
mediterranea) 		no annotation 4 ARG A 650
PHE A 251
PHE A 513
ILE A  56
 None
 1.24A 2zseA-3wevA:
undetectable		 2zseA-3wevA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amq L544

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 4 ARG A  63
PHE A  71
ILE A 192
ASN A  49
 None
 1.03A 2zseA-4amqA:
undetectable		 2zseA-4amqA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bjt DNA-BINDING PROTEIN
RAP1

(Saccharomyces
cerevisiae) 		PF11626
(Rap1_C) 		4 TYR A 768
PHE A 769
PHE A 703
ILE A 754
 None
 1.24A 2zseA-4bjtA:
undetectable		 2zseA-4bjtA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezd UREA TRANSPORTER 1

(Bos taurus) 		PF03253
(UT) 		4 TYR A 119
PHE A  66
PHE A 296
ASN A 120
 SEY  A 402 (-3.7A)
SEY  A 402 (-4.8A)
None
None
 0.96A 2zseA-4ezdA:
undetectable		 2zseA-4ezdA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f67 UPF0176 PROTEIN
LPG2838

(Legionella
pneumophila) 		PF00581
(Rhodanese) 		4 ARG A  64
PHE A  59
PHE A  49
ILE A  25
 None
 1.25A 2zseA-4f67A:
undetectable		 2zseA-4f67A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Salipiger
bermudensis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE A 206
MET A 217
PHE A 215
ILE A 173
 None
 1.18A 2zseA-4h2hA:
undetectable		 2zseA-4h2hA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3c BILIRUBIN-INDUCIBLE
FLUORESCENT PROTEIN
UNAG

(Anguilla
japonica) 		PF00061
(Lipocalin) 		4 TYR A 134
ARG A 112
PHE A  17
ILE A  11
 None
BLR  A 200 (-3.6A)
BLR  A 200 (-3.6A)
None
 1.25A 2zseA-4i3cA:
undetectable		 2zseA-4i3cA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ieg RNA-DEPENDENT RNA
POLYMERASE P2

(Pseudomonas
phage phi12) 		no annotation 4 PHE A 646
MET A 649
PHE A 650
ILE A 185
 None
 1.19A 2zseA-4iegA:
undetectable		 2zseA-4iegA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PHE A 197
PHE A 245
ILE A 187
ASN A 171
 None
 1.23A 2zseA-4jhvA:
undetectable		 2zseA-4jhvA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqs HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF06283
(ThuA) 		4 TYR A 109
PHE A 106
PHE A 137
ILE A  90
 None
 1.25A 2zseA-4jqsA:
undetectable		 2zseA-4jqsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4me3 DNA REPLICATION
LICENSING FACTOR MCM
RELATED PROTEIN

(Thermoplasma
acidophilum) 		PF17207
(MCM_OB) 		4 ARG A  20
PHE A  19
ILE A  28
ASN A  29
 None
 0.96A 2zseA-4me3A:
undetectable		 2zseA-4me3A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Psychrobacter
cryohalolentis) 		PF00561
(Abhydrolase_1) 		4 ARG A 197
MET A 174
ILE A 270
ASN A  56
 None
 1.23A 2zseA-4ns4A:
undetectable		 2zseA-4ns4A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A) 		PF00680
(RdRP_1) 		4 TYR A 236
PHE A 368
ILE A 310
ASN A 306
 None
 0.93A 2zseA-4nz0A:
undetectable		 2zseA-4nz0A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4o PHYCOCYANOBILIN
LYASE CPCT

(Nostoc sp. PCC
7120) 		PF06206
(CpeT) 		4 PHE A 152
PHE A 159
ILE A  81
ASN A  83
 None
 0.93A 2zseA-4o4oA:
undetectable		 2zseA-4o4oA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py6 BROMODOMAIN PROTEIN,
PUTATIVE

(Plasmodium
falciparum) 		PF00439
(Bromodomain) 		4 TYR A1257
PHE A1263
PHE A1298
ILE A1248
 None
 1.17A 2zseA-4py6A:
undetectable		 2zseA-4py6A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 ARG A 629
PHE A 440
ILE A 647
ASN A 638
 None
 1.24A 2zseA-4q9zA:
undetectable		 2zseA-4q9zA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ue0 FIBER

(Bovine
atadenovirus D) 		no annotation 4 MET A 430
PHE A 432
ILE A 512
ASN A 513
 None
 1.14A 2zseA-4ue0A:
undetectable		 2zseA-4ue0A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4up7 LYSINE--TRNA LIGASE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 ARG A 251
PHE A 250
ILE A 198
ASN A 200
 LAD  A1584 (-2.3A)
None
None
None
 1.23A 2zseA-4up7A:
undetectable		 2zseA-4up7A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw2 CSM1

(Thermococcus
onnurineus) 		PF01966
(HD) 		4 TYR A 626
PHE A 600
PHE A 604
ILE A 770
 None
 1.22A 2zseA-4uw2A:
undetectable		 2zseA-4uw2A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x57 UBIQUITIN-CONJUGATIN
G ENZYME E2 8

(Arabidopsis
thaliana) 		PF00179
(UQ_con) 		4 ARG A  70
PHE A  69
ILE A  78
ASN A  79
 None
 1.14A 2zseA-4x57A:
undetectable		 2zseA-4x57A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xf5 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Chromohalobacter
salexigens) 		PF03480
(DctP) 		4 PHE A 264
PHE A 246
ILE A  68
ASN A  59
 None
 1.14A 2zseA-4xf5A:
undetectable		 2zseA-4xf5A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahv ENTH DOMAIN OF EPSIN
ENT1

(Saccharomyces
cerevisiae) 		PF01417
(ENTH) 		4 TYR E  82
ARG E  85
PHE E  86
ILE E  40
 None
 0.92A 2zseA-5ahvE:
undetectable		 2zseA-5ahvE:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE

(Methanospirillum
hungatei) 		PF00485
(PRK) 		4 TYR A 221
PHE A 223
ILE A 315
ASN A 319
 None
 0.98A 2zseA-5b3fA:
17.9		 2zseA-5b3fA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e43 BETA-LACTAMASE

(Streptosporangium
roseum) 		PF13354
(Beta-lactamase2) 		4 TYR A 265
PHE A 153
ILE A 248
ASN A 246
 None
 1.23A 2zseA-5e43A:
undetectable		 2zseA-5e43A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eeb ALDEHYDE
DEHYDROGENASE

(Pyrobaculum
ferrireducens) 		PF00171
(Aldedh) 		4 PHE A  81
MET A  84
PHE A  88
ILE A 114
 None
 1.11A 2zseA-5eebA:
undetectable		 2zseA-5eebA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eul PROTEIN TRANSLOCASE
SUBUNIT SECY

(Geobacillus
thermodenitrificans) 		PF00344
(SecY) 		4 PHE Y 132
MET Y 128
ILE Y  58
ASN Y  57
 None
 1.24A 2zseA-5eulY:
undetectable		 2zseA-5eulY:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f83 BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		4 TYR A 256
PHE A 147
ILE A 241
ASN A 239
 None
 1.17A 2zseA-5f83A:
undetectable		 2zseA-5f83A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 4 ARG B 317
PHE B 315
ILE B 311
ASN B 310
 None
None
None
P32  B 400 (-3.5A)
 0.94A 2zseA-5f8uB:
undetectable		 2zseA-5f8uB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb3 NUCLEOPORIN NIC96
NUCLEOPORIN NUP53

(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		PF04097
(Nic96)
no annotation 		4 PHE B  77
PHE A 697
ILE A 659
ASN A 656
 None
 1.03A 2zseA-5hb3B:
undetectable		 2zseA-5hb3B:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1

(Homo sapiens) 		PF02230
(Abhydrolase_2) 		4 TYR A  58
PHE A  26
PHE A 145
ILE A  41
 None
 1.00A 2zseA-5kreA:
undetectable		 2zseA-5kreA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lac 3CL PROTEASE

(Alphamesonivirus
1) 		PF17222
(Peptidase_C107) 		4 TYR A 275
PHE A 278
PHE A 295
ILE A 187
 None
 1.15A 2zseA-5lacA:
undetectable		 2zseA-5lacA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		no annotation 4 TYR B4133
PHE B4128
PHE B4074
ILE B4251
 None
 1.07A 2zseA-5lp8B:
undetectable		 2zseA-5lp8B:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		4 PHE A 967
PHE A 518
ILE A1014
ASN A 936
 None
 0.92A 2zseA-5lq3A:
undetectable		 2zseA-5lq3A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m86 TA1207

(Thermoplasma
acidophilum) 		no annotation 4 MET A  40
PHE A  52
ILE A 149
ASN A 148
 None
 1.14A 2zseA-5m86A:
undetectable		 2zseA-5m86A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myf DUTPASE FROM DI S.
AUREUS PHAGE

(Staphylococcus
aureus) 		no annotation 4 PHE D 135
PHE D  92
ILE D 144
ASN D   3
 None
 1.25A 2zseA-5myfD:
undetectable		 2zseA-5myfD:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojq HAEMOLYSIN
CO-REGULATED PROTEIN

(Vibrio cholerae) 		PF05638
(T6SS_HCP) 		4 TYR 1 148
PHE 1  68
PHE 1  44
ILE 1 151
 None
 1.23A 2zseA-5ojq1:
undetectable		 2zseA-5ojq1:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulc BROMODOMAIN PROTEIN
1

(Plasmodium
falciparum) 		PF00439
(Bromodomain) 		4 TYR X 392
PHE X 398
PHE X 430
ILE X 383
 None
 1.23A 2zseA-5ulcX:
undetectable		 2zseA-5ulcX:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Saccharomyces
cerevisiae) 		PF13401
(AAA_22)
PF14630
(ORC5_C) 		4 TYR E 168
PHE E 175
ILE E  34
ASN E  32
 None
 1.12A 2zseA-5v8fE:
undetectable		 2zseA-5v8fE:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36

(Bos taurus) 		no annotation 4 PHE A 714
PHE A 915
ILE A 986
ASN A 829
 None
 1.23A 2zseA-5vhaA:
undetectable		 2zseA-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmb PANTOTHENATE KINASE

(Mycobacterium
tuberculosis) 		no annotation 5 TYR A 235
PHE A 239
MET A 242
ILE A 272
ASN A 277
 None
 0.55A 2zseA-5xmbA:
37.3		 2zseA-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN
VOLTAGE-GATED SODIUM
CHANNEL BETA SUBUNIT
1

(Electrophorus
electricus;
Electrophorus
electricus) 		PF00520
(Ion_trans)
PF06512
(Na_trans_assoc)
no annotation 		4 TYR B 185
ARG B 186
ILE A 985
ASN A 988
 None
 0.95A 2zseA-5xsyB:
undetectable		 2zseA-5xsyB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6amn HEAT SHOCK PROTEIN
104

(Saccharomyces
cerevisiae) 		no annotation 4 TYR A  62
PHE A  65
PHE A 130
ILE A  40
 None
 1.10A 2zseA-6amnA:
undetectable		 2zseA-6amnA:
undetectable