SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZS9_A_PAUA603

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cwv INVASIN

(Yersinia
pseudotuberculosis) 		PF02369
(Big_1)
PF07979
(Intimin_C)
PF09134
(Invasin_D3) 		4 VAL A 577
ASP A 512
HIS A 592
ASN A 546
 None
 1.34A 2zs9A-1cwvA:
undetectable		 2zs9A-1cwvA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2e ELONGATION FACTOR TU
(EF-TU)

(Bos taurus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 VAL A 150
ASP A 126
HIS A 124
ASN A 181
 None
MG  A 501 ( 3.9A)
None
GDP  A1301 (-3.1A)
 1.21A 2zs9A-1d2eA:
0.6		 2zs9A-1d2eA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		4 VAL A 420
ASP A 307
TYR A  63
ASN A 449
 None
GLC  A 997 (-3.6A)
None
GLC  A 998 (-3.3A)
 1.46A 2zs9A-1e4oA:
0.2		 2zs9A-1e4oA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex6 GUANYLATE KINASE

(Saccharomyces
cerevisiae) 		PF00625
(Guanylate_kin) 		4 VAL A   5
ASP A 100
LYS A 105
TYR A 156
 None
 1.29A 2zs9A-1ex6A:
5.3		 2zs9A-1ex6A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpb HUMAN PROTEIN KINASE
C INTERACTING
PROTEIN 1 (ZINC
PROTEIN)

(Homo sapiens) 		PF01230
(HIT) 		4 VAL A  54
ASP A  35
LYS A  83
HIS A  76
 None
 1.16A 2zs9A-1kpbA:
undetectable		 2zs9A-1kpbA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw7 TRANSCRIPTIONAL
REGULATOR NADR

(Haemophilus
influenzae) 		PF01467
(CTP_transf_like)
PF13521
(AAA_28) 		4 VAL A 243
HIS A 286
TYR A 289
ASN A 244
 None
None
NAD  A 605 (-3.3A)
SO4  A 607 (-4.0A)
 1.36A 2zs9A-1lw7A:
4.2		 2zs9A-1lw7A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odu PUTATIVE
ALPHA-L-FUCOSIDASE

(Thermotoga
maritima) 		PF01120
(Alpha_L_fucos) 		4 VAL A 145
ASP A 156
TYR A 216
ASN A 143
 None
 1.43A 2zs9A-1oduA:
0.0		 2zs9A-1oduA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkr AZURIN-I

(Achromobacter
xylosoxidans) 		PF00127
(Copper-bind) 		4 VAL A  43
ASP A  11
HIS A  35
ASN A  42
 None
 1.49A 2zs9A-1rkrA:
undetectable		 2zs9A-1rkrA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 VAL A 516
ASP A 509
HIS A 429
ASN A 521
 None
 1.38A 2zs9A-1rrhA:
undetectable		 2zs9A-1rrhA:
17.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sq5 PANTOTHENATE KINASE

(Escherichia
coli) 		PF00485
(PRK) 		6 VAL A1097
ASP A1127
LYS A1145
HIS A1177
TYR A1180
ASN A1282
 ADP  A5001 ( 4.4A)
PAU  A6001 (-2.9A)
None
PAU  A6001 (-4.2A)
None
PAU  A6001 (-3.0A)
 0.61A 2zs9A-1sq5A:
37.4		 2zs9A-1sq5A:
52.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE

(Sulfolobus
solfataricus) 		PF00701
(DHDPS) 		4 ASP A 139
LYS A 143
HIS A 163
ASN A 171
 None
 1.21A 2zs9A-1w3iA:
undetectable		 2zs9A-1w3iA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT

(Streptomyces
coelicolor) 		PF01039
(Carboxyl_trans) 		4 VAL A 376
ASP A 422
TYR A 401
ASN A 339
 None
 1.43A 2zs9A-1xnyA:
undetectable		 2zs9A-1xnyA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE

(Alcaligenaceae
bacterium FB188) 		PF00850
(Hist_deacetyl) 		4 VAL A  14
HIS A  36
TYR A 312
ASN A 138
 None
None
3YP  A1452 (-4.6A)
None
 1.27A 2zs9A-1zz3A:
undetectable		 2zs9A-1zz3A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		4 VAL A 455
ASP A 339
TYR A  84
ASN A 484
 None
 1.45A 2zs9A-2gj4A:
undetectable		 2zs9A-2gj4A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cei SUPEROXIDE DISMUTASE

(Helicobacter
pylori) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 VAL A  35
ASP A  74
HIS A 210
ASN A  36
 None
 1.46A 2zs9A-3ceiA:
undetectable		 2zs9A-3ceiA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		4 VAL A 455
ASP A 339
TYR A  84
ASN A 484
 NBG  A   1 ( 4.5A)
None
None
NBG  A   1 (-3.3A)
 1.47A 2zs9A-3cemA:
undetectable		 2zs9A-3cemA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3y UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF05193
(Peptidase_M16_C) 		4 VAL A 326
ASP A 319
LYS A 253
TYR A 300
 None
EDO  A 428 (-3.6A)
None
None
 1.42A 2zs9A-3d3yA:
undetectable		 2zs9A-3d3yA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqp OXIDOREDUCTASE YLBE

(Lactococcus
lactis) 		PF13460
(NAD_binding_10) 		4 VAL A   6
ASP A  49
LYS A  88
ASN A  69
 None
 1.50A 2zs9A-3dqpA:
undetectable		 2zs9A-3dqpA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eur UNCHARACTERIZED
PROTEIN

(Bacteroides
fragilis) 		PF13905
(Thioredoxin_8) 		4 ASP A 118
LYS A   7
TYR A  24
ASN A   2
 None
 1.43A 2zs9A-3eurA:
undetectable		 2zs9A-3eurA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3n PHD FINGER PROTEIN 8

(Homo sapiens) 		PF02373
(JmjC) 		4 ASP A 249
HIS A 319
TYR A 257
ASN A 189
 FE2  A   1 (-2.5A)
FE2  A   1 (-3.3A)
None
None
 1.10A 2zs9A-3k3nA:
undetectable		 2zs9A-3k3nA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv4 PHD FINGER PROTEIN 8

(Homo sapiens) 		PF00628
(PHD)
PF02373
(JmjC) 		4 ASP A 249
HIS A 319
TYR A 257
ASN A 189
 FE2  A 450 ( 2.5A)
FE2  A 450 ( 3.4A)
OGA  A5798 (-4.2A)
OGA  A5798 (-3.7A)
 1.14A 2zs9A-3kv4A:
undetectable		 2zs9A-3kv4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A

(Shewanella
denitrificans) 		PF00246
(Peptidase_M14) 		4 VAL A 318
ASP A 309
TYR A 306
ASN A 226
 None
None
None
UNL  A 378 ( 4.4A)
 1.26A 2zs9A-3l2nA:
undetectable		 2zs9A-3l2nA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9o PUTATIVE
UNCHARACTERIZED
PROTEIN

(Caenorhabditis
elegans) 		PF02373
(JmjC) 		4 ASP A 497
HIS A 567
TYR A 505
ASN A 421
 FE2  A   1 ( 2.6A)
FE2  A   1 ( 3.3A)
OGA  A   4 (-4.1A)
OGA  A   4 (-4.0A)
 1.16A 2zs9A-3n9oA:
undetectable		 2zs9A-3n9oA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2y SULFIDE-QUINONE
REDUCTASE, PUTATIVE

(Acidithiobacillus
ferrooxidans) 		PF07992
(Pyr_redox_2) 		4 VAL A  48
ASP A  56
TYR A  38
ASN A  45
 None
 1.19A 2zs9A-3t2yA:
undetectable		 2zs9A-3t2yA:
19.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tqc PANTOTHENATE KINASE

(Coxiella
burnetii) 		PF00485
(PRK) 		5 VAL A  98
ASP A 128
LYS A 146
HIS A 178
TYR A 181
 ADP  A 500 ( 4.4A)
None
None
None
None
 0.66A 2zs9A-3tqcA:
37.5		 2zs9A-3tqcA:
51.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tqc PANTOTHENATE KINASE

(Coxiella
burnetii) 		PF00485
(PRK) 		5 VAL A  98
LYS A 146
HIS A 178
TYR A 181
ASN A 283
 ADP  A 500 ( 4.4A)
None
None
None
None
 0.43A 2zs9A-3tqcA:
37.5		 2zs9A-3tqcA:
51.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus) 		PF00708
(Acylphosphatase)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 VAL A 517
ASP A 460
HIS A 483
TYR A 409
 None
None
FE  A 807 ( 3.4A)
AP2  A 806 (-4.2A)
 1.23A 2zs9A-3vthA:
undetectable		 2zs9A-3vthA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo0 IG GAMMA-2A CHAIN C
REGION, A ALLELE
E3 UBIQUITIN-PROTEIN
LIGASE TRIM21

(Mus musculus;
Mus musculus) 		PF07654
(C1-set)
PF00622
(SPRY)
PF13765
(PRY) 		4 ASP B  77
HIS A 433
TYR B  50
ASN B  97
 None
 1.49A 2zs9A-3zo0B:
undetectable		 2zs9A-3zo0B:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2s UREIDOGLYCINE
AMINOHYDROLASE

(Arabidopsis
thaliana) 		PF07883
(Cupin_2) 		4 VAL A 273
ASP A 256
LYS A  66
TYR A 259
 None
 1.49A 2zs9A-4e2sA:
undetectable		 2zs9A-4e2sA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egu HISTIDINE TRIAD
(HIT) PROTEIN

(Clostridioides
difficile) 		PF01230
(HIT) 		4 VAL A  43
ASP A  24
LYS A  72
HIS A  65
 None
 1.23A 2zs9A-4eguA:
undetectable		 2zs9A-4eguA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		4 VAL A 311
ASP A 283
HIS A 269
TYR A 270
 None
 1.31A 2zs9A-4i8vA:
undetectable		 2zs9A-4i8vA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l22 PHOSPHORYLASE

(Streptococcus
mutans) 		PF00343
(Phosphorylase) 		4 VAL A 384
ASP A 279
TYR A  54
ASN A 413
 None
 1.43A 2zs9A-4l22A:
undetectable		 2zs9A-4l22A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lbw ELONGATION FACTOR
TU-A

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 VAL A 105
ASP A  81
HIS A  79
ASN A 136
 None
MG  A 502 ( 4.0A)
None
GNP  A 501 (-3.2A)
 1.16A 2zs9A-4lbwA:
2.5		 2zs9A-4lbwA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lt5 NAEGLERIA TET-LIKE
DIOXYGENASE

(Naegleria
gruberi) 		no annotation 4 VAL A 293
ASP A 234
HIS A 297
ASN A 214
 OGA  A 413 (-4.9A)
None
None
OGA  A 413 (-3.3A)
 1.36A 2zs9A-4lt5A:
undetectable		 2zs9A-4lt5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2
CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus;
Aspergillus
fumigatus) 		PF01239
(PPTA)
PF00432
(Prenyltrans) 		4 ASP B 148
HIS A  73
TYR A  74
ASN B 185
 EDO  A 401 (-2.8A)
EDO  A 402 (-4.1A)
None
None
 1.22A 2zs9A-4mbgB:
undetectable		 2zs9A-4mbgB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A

(Mus musculus) 		PF02373
(JmjC) 		4 ASP A 214
HIS A 284
TYR A 222
ASN A 142
 NI  A 601 ( 2.5A)
NI  A 601 ( 3.4A)
None
AKG  A 602 (-3.8A)
 1.08A 2zs9A-4qx8A:
undetectable		 2zs9A-4qx8A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yw5 NEURAMINIDASE C

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		4 VAL A 627
ASP A 685
HIS A 664
TYR A 693
 None
 1.48A 2zs9A-4yw5A:
undetectable		 2zs9A-4yw5A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2q LECTIN

(Athelia rolfsii) 		PF07367
(FB_lectin) 		4 VAL A  41
ASP A 133
HIS A 135
TYR A 126
 None
 1.25A 2zs9A-4z2qA:
undetectable		 2zs9A-4z2qA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cg9 TET-LIKE DIOXYGENASE

(Naegleria
gruberi) 		no annotation 4 VAL A 293
ASP A 234
HIS A 297
ASN A 214
 AKG  A 402 (-4.8A)
None
None
AKG  A 402 (-3.5A)
 1.28A 2zs9A-5cg9A:
undetectable		 2zs9A-5cg9A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		4 VAL A 125
ASP A 225
HIS A 310
ASN A 232
 None
 1.39A 2zs9A-5fsaA:
undetectable		 2zs9A-5fsaA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy0 GLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		4 VAL A  58
HIS A 389
TYR A  75
ASN A  56
 None
 1.49A 2zs9A-5gy0A:
undetectable		 2zs9A-5gy0A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		4 VAL A 455
ASP A 339
TYR A  84
ASN A 484
 None
 1.47A 2zs9A-5ikpA:
undetectable		 2zs9A-5ikpA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inr DIPEPTIDASE

(Lactobacillus
farciminis) 		PF03577
(Peptidase_C69) 		4 VAL A 396
ASP A 298
HIS A 291
ASN A 400
 None
 1.09A 2zs9A-5inrA:
undetectable		 2zs9A-5inrA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		4 VAL A 584
ASP A 383
TYR A 131
ASN A 613
 None
None
None
GLC  A1001 (-3.8A)
 1.48A 2zs9A-5lrbA:
undetectable		 2zs9A-5lrbA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 VAL A 211
ASP A  82
HIS A  75
TYR A 438
 None
 1.48A 2zs9A-5m8tA:
undetectable		 2zs9A-5m8tA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae) 		PF13691
(Lactamase_B_4) 		4 VAL A 181
ASP A 176
LYS A 160
HIS A 178
 None
 1.42A 2zs9A-5mtzA:
undetectable		 2zs9A-5mtzA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz8 ALDEHYDE
DEHYDROGENASE 21

(Physcomitrella
patens) 		PF00171
(Aldedh) 		4 ASP A 459
HIS A 179
TYR A 463
ASN A 171
 None
None
SIN  A 501 (-4.7A)
SIN  A 501 (-3.4A)
 1.19A 2zs9A-5mz8A:
undetectable		 2zs9A-5mz8A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrf CADMIUM AND ZINC
EFFLUX PUMP FIEF

(Shewanella
oneidensis) 		no annotation 4 ASP B  47
HIS B 155
TYR B 156
ASN B  58
 ZN  B 301 (-2.1A)
ZN  B 301 (-3.2A)
None
None
 1.40A 2zs9A-5vrfB:
undetectable		 2zs9A-5vrfB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7q CONSENSUS ELONGATION
FACTOR

(synthetic
construct) 		no annotation 4 VAL A 105
ASP A  81
HIS A  79
ASN A 136
 None
GDP  A 402 ( 4.8A)
None
GDP  A 402 (-2.9A)
 1.14A 2zs9A-5w7qA:
undetectable		 2zs9A-5w7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmb PANTOTHENATE KINASE

(Mycobacterium
tuberculosis) 		no annotation 5 VAL A  99
ASP A 129
LYS A 147
HIS A 179
ASN A 277
 SO4  A 401 ( 4.2A)
None
None
None
None
 1.17A 2zs9A-5xmbA:
37.6		 2zs9A-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmb PANTOTHENATE KINASE

(Mycobacterium
tuberculosis) 		no annotation 4 VAL A  99
ASP A 129
TYR A 182
ASN A 277
 SO4  A 401 ( 4.2A)
None
None
None
 1.09A 2zs9A-5xmbA:
37.6		 2zs9A-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqj BETA-XYLOSIDASE

(Bacillus
pumilus) 		no annotation 4 VAL A   7
ASP A  44
TYR A 260
ASN A   5
 None
 1.25A 2zs9A-5zqjA:
undetectable		 2zs9A-5zqjA:
undetectable