SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZQ9_A_CLSA11

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT

(Methanopyrus
kandleri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 GLU A  42
ARG A  39
ASN A  93
ASP A  88
 None
 1.03A 2zq9A-1e6vA:
0.0		 2zq9A-1e6vA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanosarcina
barkeri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 GLU A1051
ARG A1048
ASN A1104
ASP A1099
 None
 1.09A 2zq9A-1e6yA:
0.1		 2zq9A-1e6yA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fep FERRIC ENTEROBACTIN
RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLU A 564
ARG A 529
ASN A 530
ASP A 531
 None
 1.28A 2zq9A-1fepA:
0.0		 2zq9A-1fepA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1geu GLUTATHIONE
REDUCTASE

(Escherichia
coli) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLU A 264
ARG A 142
ASN A 267
ASP A 268
 None
 1.09A 2zq9A-1geuA:
1.5		 2zq9A-1geuA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im3 CYTOMEGALOVIRUS
PROTEIN US2

(Human
betaherpesvirus
5) 		PF05963
(Cytomega_US3) 		4 GLU D 136
ARG D  51
ASN D  50
ASP D  49
 None
 1.42A 2zq9A-1im3D:
0.0		 2zq9A-1im3D:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1io0 TROPOMODULIN

(Gallus gallus) 		no annotation 4 GLU A 185
ARG A 189
ASN A 192
ASP A 194
 None
 0.92A 2zq9A-1io0A:
undetectable		 2zq9A-1io0A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kxh ALPHA-AMYLASE

(Pseudoalteromonas
haloplanktis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 GLU A  21
ARG A  73
ASN A  72
ASP A  69
 None
 1.43A 2zq9A-1kxhA:
0.0		 2zq9A-1kxhA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		4 GLU A 263
ARG A 130
ASN A 131
ASP A 127
 None
 1.50A 2zq9A-1lf9A:
0.0		 2zq9A-1lf9A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 GLU A  39
ARG A  36
ASN A  90
ASP A  85
 None
 1.10A 2zq9A-1mroA:
0.0		 2zq9A-1mroA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orr CDP-TYVELOSE-2-EPIME
RASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		4 GLU A  98
ARG A  60
ASN A  61
ASP A  58
 None
None
None
NAD  A1200 (-3.8A)
 1.46A 2zq9A-1orrA:
undetectable		 2zq9A-1orrA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))

(Sulfolobus
solfataricus) 		PF00117
(GATase) 		4 GLU B  35
ARG B  32
ASN B   9
ASP B   8
 None
 1.33A 2zq9A-1qdlB:
undetectable		 2zq9A-1qdlB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcu CONSERVED
HYPOTHETICAL PROTEIN
VT76

(Thermotoga
maritima) 		PF03641
(Lysine_decarbox) 		4 GLU A  70
ARG A  44
ASN A  73
ASP A  45
 None
 1.03A 2zq9A-1rcuA:
undetectable		 2zq9A-1rcuA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		4 GLU A 436
ARG A 355
ASN A 357
ASP A 399
 None
 1.45A 2zq9A-1s0uA:
undetectable		 2zq9A-1s0uA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bjq MFP2A

(Ascaris suum) 		PF12150
(MFP2b) 		4 GLU A  98
ARG A 100
ASN A 107
ASP A 104
 None
 1.50A 2zq9A-2bjqA:
undetectable		 2zq9A-2bjqA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5a HYPOTHETICAL PROTEIN
PH1109

(Pyrococcus
horikoshii) 		PF13380
(CoA_binding_2) 		4 GLU A 136
ARG A 131
ASN A 130
ASP A   8
 None
 1.48A 2zq9A-2d5aA:
undetectable		 2zq9A-2d5aA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		4 GLU A 242
ARG A 231
ASN A 233
ASP A 240
 None
 1.24A 2zq9A-2pi5A:
undetectable		 2zq9A-2pi5A:
15.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wyx BETA-LACTAMSE TOHO-1

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		4 GLU A 273
ARG A 275
ASN A 276
ASP A 277
 None
 0.37A 2zq9A-2wyxA:
47.7		 2zq9A-2wyxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywv PHOSPHORIBOSYLAMINOI
MIDAZOLE
SUCCINOCARBOXAMIDE
SYNTHETASE

(Geobacillus
kaustophilus) 		PF01259
(SAICAR_synt) 		4 GLU A 120
ARG A  95
ASN A  96
ASP A 176
 None
SO4  A 543 (-3.3A)
None
SO4  A 543 ( 4.6A)
 1.47A 2zq9A-2ywvA:
undetectable		 2zq9A-2ywvA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 GLU A1210
ARG A1168
ASN A1167
ASP A1166
 None
 1.26A 2zq9A-2zxqA:
undetectable		 2zq9A-2zxqA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLU A 292
ARG A 294
ASN A 295
ASP A 313
 None
 1.18A 2zq9A-3abgA:
undetectable		 2zq9A-3abgA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehk PRUNIN

(Prunus dulcis) 		PF00190
(Cupin_1) 		4 GLU A  29
ARG A 301
ASN A 300
ASP A 299
 None
 1.13A 2zq9A-3ehkA:
undetectable		 2zq9A-3ehkA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbd SUCROSE ISOMERASE
SMUA FROM
PROTAMINOBACTER
RUBRUM

(Serratia
plymuthica) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 GLU A 401
ARG A 429
ASN A 343
ASP A 342
 EDO  A8002 (-3.3A)
EDO  A8003 ( 3.2A)
None
EDO  A8002 ( 3.5A)
 1.40A 2zq9A-3gbdA:
undetectable		 2zq9A-3gbdA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgl CRUCIFERIN

(Brassica napus) 		PF00190
(Cupin_1) 		4 GLU A  24
ARG A 249
ASN A 248
ASP A 247
 None
 1.28A 2zq9A-3kglA:
0.5		 2zq9A-3kglA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on1 BH2414 PROTEIN

(Bacillus
halodurans) 		PF01248
(Ribosomal_L7Ae) 		4 GLU A  80
ARG A  69
ASN A  68
ASP A  43
 None
 1.01A 2zq9A-3on1A:
undetectable		 2zq9A-3on1A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT

(uncultured
archaeon) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 GLU A  45
ARG A  42
ASN A  98
ASP A  93
 None
 1.28A 2zq9A-3sqgA:
0.0		 2zq9A-3sqgA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw0 PECTINESTERASE

(Yersinia
enterocolitica) 		PF01095
(Pectinesterase) 		4 GLU A 173
ARG A 129
ASN A 130
ASP A 131
 None
 1.09A 2zq9A-3uw0A:
undetectable		 2zq9A-3uw0A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgj SORTING NEXIN-14

(Homo sapiens) 		PF00787
(PX) 		4 GLU A 556
ARG A 548
ASN A 546
ASP A 547
 None
 1.43A 2zq9A-4bgjA:
undetectable		 2zq9A-4bgjA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1k THROMBOSPONDIN
RELATED ANONYMOUS
PROTEIN

(Plasmodium
falciparum) 		PF00092
(VWA) 		4 GLU A  46
ARG A 150
ASN A 149
ASP A  48
 EDO  A 307 (-3.7A)
EDO  A 307 (-3.9A)
None
None
 1.50A 2zq9A-4f1kA:
undetectable		 2zq9A-4f1kA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks9 MALONYL-COA
DECARBOXYLASE

(Cupriavidus
metallidurans) 		PF05292
(MCD)
PF17408
(MCD_N) 		4 GLU A 255
ARG A 231
ASN A 230
ASP A 227
 None
 1.27A 2zq9A-4ks9A:
undetectable		 2zq9A-4ks9A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Methanocaldococcus
jannaschii) 		PF02350
(Epimerase_2) 		4 GLU A 250
ARG A 247
ASN A 214
ASP A 213
 None
 1.50A 2zq9A-4nesA:
undetectable		 2zq9A-4nesA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE

(Gallus gallus;
Lobophyllia
hemprichii;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 GLU A 330
ARG A 344
ASN A 345
ASP A 346
 GOL  A 504 (-4.7A)
None
CR8  A 303 ( 4.1A)
None
 1.46A 2zq9A-4oy4A:
undetectable		 2zq9A-4oy4A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po4 LAMPETRA PLANERI
VLRC

(Lampetra
planeri) 		PF13855
(LRR_8) 		4 GLU A  92
ARG A  94
ASN A  48
ASP A  72
 None
 1.41A 2zq9A-4po4A:
undetectable		 2zq9A-4po4A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO

(Escherichia
coli) 		PF02624
(YcaO) 		4 GLU A 369
ARG A 160
ASN A 164
ASP A 163
 None
 1.05A 2zq9A-4q85A:
1.9		 2zq9A-4q85A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3f DYNAMIN 3

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		4 GLU A  82
ARG A 123
ASN A 121
ASP A  18
 None
 1.16A 2zq9A-5a3fA:
undetectable		 2zq9A-5a3fA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 GLU A  41
ARG A  38
ASN A  93
ASP A  88
 None
 1.08A 2zq9A-5a8rA:
1.3		 2zq9A-5a8rA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		4 GLU A 372
ARG A  64
ASN A 105
ASP A  17
 None
 0.96A 2zq9A-5dmhA:
undetectable		 2zq9A-5dmhA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn6 ATP SYNTHASE SUBUNIT
ALPHA

(Paracoccus
denitrificans) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 GLU A 394
ARG A 421
ASN A 420
ASP A 455
 None
 1.36A 2zq9A-5dn6A:
undetectable		 2zq9A-5dn6A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		4 GLU A 296
ARG A 300
ASN A 303
ASP A 305
 None
 1.10A 2zq9A-5eykA:
undetectable		 2zq9A-5eykA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj1 PULLULANASE C
PROTEIN

(Klebsiella
pneumoniae) 		no annotation 4 GLU A 267
ARG A 266
ASN A 230
ASP A 231
 None
 1.46A 2zq9A-5hj1A:
undetectable		 2zq9A-5hj1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd0 AROMATIC
PRENYLTRANSFERASE

(Aspergillus
terreus) 		PF11991
(Trp_DMAT) 		4 GLU A 378
ARG A 374
ASN A 373
ASP A 370
 None
 1.17A 2zq9A-5kd0A:
undetectable		 2zq9A-5kd0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 GLU B 402
ARG B 362
ASN B 369
ASP B 368
 None
 1.45A 2zq9A-5ldrB:
undetectable		 2zq9A-5ldrB:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzs FERRIC ENTEROBACTIN
RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 4 GLU A 567
ARG A 526
ASN A 527
ASP A 528
 None
 1.27A 2zq9A-5mzsA:
undetectable		 2zq9A-5mzsA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanotorris
formicicus) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 GLU A  41
ARG A  38
ASN A  93
ASP A  88
 None
 1.23A 2zq9A-5n28A:
1.3		 2zq9A-5n28A:
20.00