SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZQ0_B_ACRB811_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wfa ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		9 TRP A 331
TRP A 341
GLU A 391
TRP A 400
GLU A 439
VAL A 471
HIS A 507
PHE A 536
GLY A 537
 None
 0.18A 2zq0B-3wfaA:
66.8		 2zq0B-3wfaA:
97.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wfa ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		9 TRP A 331
TRP A 341
GLU A 391
TRP A 400
GLU A 439
VAL A 471
HIS A 507
PHE A 536
GLY A 538
 None
 0.85A 2zq0B-3wfaA:
66.8		 2zq0B-3wfaA:
97.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hqb ALPHA-GLUCOSIDASE

(Pseudoalteromonas
sp. K8) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		7 TRP A 289
TRP A 299
GLU A 330
TRP A 340
GLU A 377
VAL A 409
HIS A 455
 GLC  A 711 (-4.1A)
GLC  A 711 (-4.5A)
GLC  A 711 (-2.7A)
GLC  A 711 (-4.8A)
GLC  A 711 (-3.7A)
GLC  A 712 (-4.7A)
GLC  A 711 (-3.7A)
 0.49A 2zq0B-5hqbA:
57.0		 2zq0B-5hqbA:
39.61