SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZQ0_A_ACRA801_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqi RIBOSOME-INACTIVATIN
G PROTEIN 3

(Zea mays) 		PF00161
(RIP) 		5 TRP A  72
VAL A  96
HIS A 115
GLU A 107
GLY A 102
 None
 1.50A 2zq0A-2pqiA:
0.0		 2zq0A-2pqiA:
15.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wfa ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		9 TRP A 331
TRP A 341
TRP A 400
GLU A 439
VAL A 471
HIS A 507
GLU A 508
PHE A 536
GLY A 537
 None
None
None
None
None
None
NA  A 801 (-3.8A)
None
None
 0.19A 2zq0A-3wfaA:
63.0		 2zq0A-3wfaA:
97.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wfa ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		9 TRP A 331
TRP A 341
TRP A 400
GLU A 439
VAL A 471
HIS A 507
GLU A 508
PHE A 536
GLY A 538
 None
None
None
None
None
None
NA  A 801 (-3.8A)
None
None
 0.85A 2zq0A-3wfaA:
63.0		 2zq0A-3wfaA:
97.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Actinobacillus
succinogenes) 		PF03480
(DctP) 		5 GLU A  26
VAL A  61
GLU A  28
PHE A 245
GLY A 242
 None
 1.47A 2zq0A-4o8mA:
0.0		 2zq0A-4o8mA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		5 GLU A 784
HIS A 743
GLU A 786
PHE A1383
GLY A1384
 None
 1.40A 2zq0A-4o9xA:
undetectable		 2zq0A-4o9xA:
16.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hqb ALPHA-GLUCOSIDASE

(Pseudoalteromonas
sp. K8) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		5 GLU A 377
VAL A 409
HIS A 455
GLU A 456
PHE A 481
 GLC  A 711 (-3.7A)
GLC  A 712 (-4.7A)
GLC  A 711 (-3.7A)
CA  A 701 ( 3.4A)
None
 1.34A 2zq0A-5hqbA:
48.8		 2zq0A-5hqbA:
39.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hqb ALPHA-GLUCOSIDASE

(Pseudoalteromonas
sp. K8) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		7 TRP A 289
TRP A 299
TRP A 340
GLU A 377
VAL A 409
HIS A 455
GLU A 456
 GLC  A 711 (-4.1A)
GLC  A 711 (-4.5A)
GLC  A 711 (-4.8A)
GLC  A 711 (-3.7A)
GLC  A 712 (-4.7A)
GLC  A 711 (-3.7A)
CA  A 701 ( 3.4A)
 0.47A 2zq0A-5hqbA:
48.8		 2zq0A-5hqbA:
39.61