SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZMB_A_PXBA692_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		3 PRO A 593
GLU A 659
TYR A 660
 None
 0.59A 2zmbA-1biyA:
54.5		 2zmbA-1biyA:
91.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1blu FERREDOXIN

(Allochromatium
vinosum) 		PF00037
(Fer4) 		3 PRO A  19
GLU A  51
TYR A  44
 SF4  A 102 ( 4.9A)
None
None
 0.82A 2zmbA-1bluA:
undetectable		 2zmbA-1bluA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		3 PRO A 692
GLU A 584
TYR A 587
 None
 0.79A 2zmbA-1c4kA:
undetectable		 2zmbA-1c4kA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqz PROTEIN (ANTIGEN
85-C)

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		3 PRO A  69
GLU A  96
TYR A  77
 None
 0.74A 2zmbA-1dqzA:
0.0		 2zmbA-1dqzA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elv COMPLEMENT C1S
COMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		3 PRO A 347
GLU A 385
TYR A 369
 None
 0.66A 2zmbA-1elvA:
undetectable		 2zmbA-1elvA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09083
(DUF1923) 		3 PRO A  91
GLU A 183
TYR A 170
 None
 0.72A 2zmbA-1gjuA:
0.0		 2zmbA-1gjuA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 PRO A 576
GLU A 666
TYR A 646
 None
 0.77A 2zmbA-1hwwA:
undetectable		 2zmbA-1hwwA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1irx LYSYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01921
(tRNA-synt_1f) 		3 PRO A 299
GLU A 295
TYR A 294
 None
 0.70A 2zmbA-1irxA:
1.6		 2zmbA-1irxA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		3 PRO A 306
GLU A 221
TYR A 290
 None
 0.80A 2zmbA-1kcxA:
0.0		 2zmbA-1kcxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		3 PRO D 300
GLU D 373
TYR D 376
 None
 0.68A 2zmbA-1mhzD:
undetectable		 2zmbA-1mhzD:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mnn NDT80 PROTEIN

(Saccharomyces
cerevisiae) 		PF05224
(NDT80_PhoG) 		3 PRO A 185
GLU A 253
TYR A 252
 None
 0.80A 2zmbA-1mnnA:
undetectable		 2zmbA-1mnnA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		3 PRO A 524
GLU A 536
TYR A 535
 None
None
GOL  A 753 (-4.3A)
 0.81A 2zmbA-1mqqA:
undetectable		 2zmbA-1mqqA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus) 		PF02332
(Phenol_Hydrox) 		3 PRO D 300
GLU D 373
TYR D 376
 None
 0.66A 2zmbA-1mtyD:
undetectable		 2zmbA-1mtyD:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrf REGULATORY PROTEIN
BLAR1

(Bacillus
licheniformis) 		PF00905
(Transpeptidase) 		3 PRO A 400
GLU A 479
TYR A 476
 None
 0.75A 2zmbA-1nrfA:
undetectable		 2zmbA-1nrfA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qub PROTEIN (HUMAN
BETA2-GLYCOPROTEIN
I)

(Homo sapiens) 		PF00084
(Sushi)
PF09014
(Sushi_2) 		3 PRO A  17
GLU A  23
TYR A  22
 None
 0.70A 2zmbA-1qubA:
undetectable		 2zmbA-1qubA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s68 RNA LIGASE 2

(Escherichia
virus T4) 		PF09414
(RNA_ligase) 		3 PRO A 165
GLU A 204
TYR A 206
 None
 0.81A 2zmbA-1s68A:
undetectable		 2zmbA-1s68A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfr ANTIGEN 85-A

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		3 PRO A  71
GLU A  98
TYR A  79
 None
 0.82A 2zmbA-1sfrA:
undetectable		 2zmbA-1sfrA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szi MANNOSE-6-PHOSPHATE
RECEPTOR BINDING
PROTEIN 1

(Mus musculus) 		PF03036
(Perilipin) 		3 PRO A 417
GLU A 410
TYR A 411
 None
 0.52A 2zmbA-1sziA:
undetectable		 2zmbA-1sziA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 PRO B  51
GLU B 139
TYR B 138
 None
 0.69A 2zmbA-1t3qB:
undetectable		 2zmbA-1t3qB:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7l HYPOTHETICAL
UBIQUITIN-CONJUGATIN
G ENZYME LOC55284

(Homo sapiens) 		PF00179
(UQ_con) 		3 PRO A  79
GLU A  50
TYR A  49
 None
 0.75A 2zmbA-2a7lA:
undetectable		 2zmbA-2a7lA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON

(Salmonella
enterica) 		PF01569
(PAP2) 		3 PRO A 131
GLU A  55
TYR A  57
 None
 0.73A 2zmbA-2akcA:
undetectable		 2zmbA-2akcA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avu FLAGELLAR
TRANSCRIPTIONAL
ACTIVATOR FLHC

(Escherichia
coli) 		PF05280
(FlhC) 		3 PRO E 113
GLU E 104
TYR E 102
 None
 0.75A 2zmbA-2avuE:
undetectable		 2zmbA-2avuE:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dat POSSIBLE GLOBAL
TRANSCRIPTION
ACTIVATOR SNF2L2

(Homo sapiens) 		PF00439
(Bromodomain) 		3 PRO A  44
GLU A  54
TYR A  53
 None
 0.80A 2zmbA-2datA:
undetectable		 2zmbA-2datA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2df0 PEPTIDE YY

(Homo sapiens) 		PF00159
(Hormone_3) 		3 PRO A   3
GLU A  14
TYR A  18
 None
 0.63A 2zmbA-2df0A:
undetectable		 2zmbA-2df0A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfs MYOSIN-5A

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ) 		3 PRO A  60
GLU A  49
TYR A  50
 None
 0.79A 2zmbA-2dfsA:
undetectable		 2zmbA-2dfsA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dl5 KIAA0769 PROTEIN

(Homo sapiens) 		PF00018
(SH3_1) 		3 PRO A  63
GLU A  33
TYR A  22
 None
 0.78A 2zmbA-2dl5A:
undetectable		 2zmbA-2dl5A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e54 ACETYLORNITHINE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00202
(Aminotran_3) 		3 PRO A 179
GLU A 195
TYR A 229
 None
 0.68A 2zmbA-2e54A:
undetectable		 2zmbA-2e54A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eqs ATP-DEPENDENT RNA
HELICASE DHX8

(Homo sapiens) 		PF00575
(S1) 		3 PRO A 262
GLU A 285
TYR A 268
 None
 0.60A 2zmbA-2eqsA:
undetectable		 2zmbA-2eqsA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgo FERREDOXIN

(Pseudomonas
aeruginosa) 		PF00037
(Fer4) 		3 PRO A  19
GLU A  46
TYR A  44
 None
 0.66A 2zmbA-2fgoA:
undetectable		 2zmbA-2fgoA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5g AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		3 PRO A 191
GLU A 133
TYR A 132
 None
 0.47A 2zmbA-2i5gA:
undetectable		 2zmbA-2i5gA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkm MORTALITY FACTOR
4-LIKE PROTEIN 1

(Homo sapiens) 		PF05712
(MRG) 		3 PRO B 240
GLU B 317
TYR B 318
 None
 0.78A 2zmbA-2lkmB:
undetectable		 2zmbA-2lkmB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mt6 UBIQUITIN-CONJUGATIN
G ENZYME E2 W

(Homo sapiens) 		PF00179
(UQ_con) 		3 PRO A  79
GLU A  50
TYR A  49
 None
 0.81A 2zmbA-2mt6A:
undetectable		 2zmbA-2mt6A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2na2 RIBONUCLEASE 3

(Homo sapiens) 		PF00035
(dsrm) 		3 PRO A  27
GLU A  52
TYR A  48
 None
 0.65A 2zmbA-2na2A:
undetectable		 2zmbA-2na2A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		3 PRO A 734
GLU A 309
TYR A 308
 None
 0.78A 2zmbA-2pi5A:
undetectable		 2zmbA-2pi5A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qrw HEMOGLOBIN-LIKE
PROTEIN HBO

(Mycobacterium
tuberculosis) 		PF01152
(Bac_globin) 		3 PRO A  69
GLU A  64
TYR A  62
 None
None
HEM  A 700 (-4.4A)
 0.81A 2zmbA-2qrwA:
undetectable		 2zmbA-2qrwA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4

(Saccharomyces
cerevisiae) 		PF00439
(Bromodomain) 		3 PRO A 232
GLU A 227
TYR A 225
 None
 0.77A 2zmbA-2r0vA:
undetectable		 2zmbA-2r0vA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4

(Saccharomyces
cerevisiae) 		PF00439
(Bromodomain) 		3 PRO A 232
GLU A 227
TYR A 226
 None
 0.77A 2zmbA-2r0vA:
undetectable		 2zmbA-2r0vA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl6 MINICHROMOSOME
MAINTENANCE PROTEIN
MCM

(Sulfolobus
solfataricus) 		PF14551
(MCM_N)
PF17207
(MCM_OB) 		3 PRO A 168
GLU A 152
TYR A 142
 None
 0.80A 2zmbA-2vl6A:
undetectable		 2zmbA-2vl6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA

(Aspergillus
nidulans) 		PF05368
(NmrA) 		3 PRO A 163
GLU A 260
TYR A 258
 None
 0.81A 2zmbA-2vutA:
1.1		 2zmbA-2vutA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2g NON-STRUCTURAL
PROTEIN 3

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF11633
(SUD-M) 		3 PRO A 548
GLU A 571
TYR A 583
 None
 0.77A 2zmbA-2w2gA:
undetectable		 2zmbA-2w2gA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0e UDP-GLUCOSE
DEHYDROGENASE

(Burkholderia
cepacia) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		3 PRO A 413
GLU A 435
TYR A 434
 None
 0.75A 2zmbA-2y0eA:
1.9		 2zmbA-2y0eA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b40 PROBABLE DIPEPTIDASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		3 PRO A 334
GLU A 349
TYR A 350
 None
MG  A 449 (-2.2A)
None
 0.74A 2zmbA-3b40A:
undetectable		 2zmbA-3b40A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cm0 ADENYLATE KINASE

(Thermus
thermophilus) 		PF00406
(ADK) 		3 PRO A  13
GLU A 145
TYR A 147
 None
 0.71A 2zmbA-3cm0A:
undetectable		 2zmbA-3cm0A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3

(Saccharomyces
cerevisiae) 		PF03571
(Peptidase_M49) 		3 PRO A 486
GLU A 373
TYR A 372
 None
 0.78A 2zmbA-3cskA:
undetectable		 2zmbA-3cskA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgb UNCHARACTERIZED
PROTEIN Q89ZH8_BACTN

(Bacteroides
thetaiotaomicron) 		PF10282
(Lactonase) 		3 PRO A 186
GLU A 261
TYR A 262
 None
 0.81A 2zmbA-3fgbA:
undetectable		 2zmbA-3fgbA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1l HEMAGGLUTININ-ESTERA
SE PROTEIN

(Porcine
torovirus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		3 PRO A 276
GLU A 233
TYR A 232
 None
 0.67A 2zmbA-3i1lA:
undetectable		 2zmbA-3i1lA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3o SHORT CHAIN
DEHYDROGENASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		3 PRO A 260
GLU A  32
TYR A  36
 None
 0.80A 2zmbA-3i3oA:
undetectable		 2zmbA-3i3oA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu5 PROTEIN POLYBROMO-1

(Homo sapiens) 		PF00439
(Bromodomain) 		3 PRO A  91
GLU A  86
TYR A  84
 None
 0.73A 2zmbA-3iu5A:
undetectable		 2zmbA-3iu5A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq3 LOMBRICINE KINASE

(Urechis caupo) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 PRO A  12
GLU A  28
TYR A  30
 None
 0.78A 2zmbA-3jq3A:
undetectable		 2zmbA-3jq3A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7n K-LIKE

(Naja atra) 		PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		3 PRO A 393
GLU A 386
TYR A 387
 None
 0.64A 2zmbA-3k7nA:
undetectable		 2zmbA-3k7nA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2t PROBABLE
DEHYDROGENASE

(Chromobacterium
violaceum) 		PF01408
(GFO_IDH_MocA) 		3 PRO A  99
GLU A 107
TYR A 318
 None
 0.76A 2zmbA-3m2tA:
1.9		 2zmbA-3m2tA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mf9 ENDO-1,4-BETA-XYLANA
SE

(Thermopolyspora
flexuosa) 		PF00457
(Glyco_hydro_11) 		3 PRO A 100
GLU A 119
TYR A 118
 None
 0.66A 2zmbA-3mf9A:
undetectable		 2zmbA-3mf9A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5e ATLASTIN-1

(Homo sapiens) 		PF02263
(GBP) 		3 PRO A 208
GLU A 195
TYR A 196
 None
 0.76A 2zmbA-3q5eA:
undetectable		 2zmbA-3q5eA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfo PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF12850
(Metallophos_2) 		3 PRO A  43
GLU A 241
TYR A 243
 None
 0.72A 2zmbA-3qfoA:
undetectable		 2zmbA-3qfoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt2 INTERLEUKIN-5
RECEPTOR SUBUNIT
ALPHA

(Homo sapiens) 		PF09240
(IL6Ra-bind) 		3 PRO A  13
GLU A  58
TYR A  45
 None
 0.64A 2zmbA-3qt2A:
undetectable		 2zmbA-3qt2A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 PRO A 132
GLU A 314
TYR A 156
 None
 0.78A 2zmbA-3sunA:
undetectable		 2zmbA-3sunA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 PRO A 792
GLU A 798
TYR A 800
 None
 0.81A 2zmbA-3v5qA:
undetectable		 2zmbA-3v5qA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9a PUTATIVE
UNCHARACTERIZED
PROTEIN

(Coprinopsis
cinerea) 		no annotation 3 PRO A 126
GLU A 131
TYR A 146
 None
GOL  A 503 ( 4.4A)
None
 0.69A 2zmbA-3w9aA:
undetectable		 2zmbA-3w9aA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		3 PRO A 350
GLU A 319
TYR A 321
 None
 0.67A 2zmbA-3wfzA:
undetectable		 2zmbA-3wfzA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Cupriavidus
necator) 		PF01370
(Epimerase) 		3 PRO A 250
GLU A 269
TYR A 268
 None
 0.73A 2zmbA-3wmxA:
undetectable		 2zmbA-3wmxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjk BETA GLYCOSIDASE

(Thermus
thermophilus) 		PF00232
(Glyco_hydro_1) 		3 PRO A 316
GLU A 357
TYR A 361
 None
 0.75A 2zmbA-3zjkA:
undetectable		 2zmbA-3zjkA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0

(Escherichia
coli) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		3 PRO A 105
GLU A 111
TYR A 110
 MIY  A1204 (-4.4A)
None
None
 0.58A 2zmbA-4ac0A:
undetectable		 2zmbA-4ac0A:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE

(Trichoderma
reesei) 		PF00704
(Glyco_hydro_18) 		3 PRO X 217
GLU X 166
TYR X 207
 None
 0.82A 2zmbA-4ac1X:
undetectable		 2zmbA-4ac1X:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 PRO A 306
GLU A 221
TYR A 290
 None
 0.73A 2zmbA-4cnsA:
undetectable		 2zmbA-4cnsA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 PRO A 306
GLU A 221
TYR A 290
 None
 0.79A 2zmbA-4cntA:
undetectable		 2zmbA-4cntA:
19.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fim LACTOTRANSFERRIN

(Bos taurus) 		PF00405
(Transferrin) 		3 PRO A 593
GLU A 659
TYR A 660
 CEL  A 711 (-4.3A)
ZN  A 703 ( 1.9A)
CEL  A 711 (-4.4A)
 0.09A 2zmbA-4fimA:
57.6		 2zmbA-4fimA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igv KIROLA

(Actinidia
deliciosa) 		PF00407
(Bet_v_1) 		3 PRO A 130
GLU A 121
TYR A  96
 None
 0.80A 2zmbA-4igvA:
undetectable		 2zmbA-4igvA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inz SOLUBLE EPOXIDE
HYDROLASE

(Bacillus
megaterium) 		PF00561
(Abhydrolase_1) 		3 PRO A  64
GLU A  71
TYR A  70
 None
 0.73A 2zmbA-4inzA:
undetectable		 2zmbA-4inzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kwm HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 PRO A  49
GLU A 270
TYR A 271
 None
 0.76A 2zmbA-4kwmA:
undetectable		 2zmbA-4kwmA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kyn ODORANT BINDING
PROTEIN-8

(Anopheles
gambiae) 		no annotation 3 PRO A 170
GLU A 164
TYR A 165
 None
 0.82A 2zmbA-4kynA:
undetectable		 2zmbA-4kynA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcb CELL DIVISION
PROTEIN CDVC, VPS4

(Acidianus
hospitalis) 		PF00004
(AAA)
PF09336
(Vps4_C) 		3 PRO A 247
GLU A 356
TYR A 355
 None
 0.77A 2zmbA-4lcbA:
undetectable		 2zmbA-4lcbA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		3 PRO A 369
GLU A 385
TYR A 384
 None
 0.73A 2zmbA-4madA:
undetectable		 2zmbA-4madA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo sapiens) 		PF01728
(FtsJ) 		3 PRO A 149
GLU A 225
TYR A 224
 None
 0.64A 2zmbA-4n49A:
0.7		 2zmbA-4n49A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ova FRAGILE X MENTAL
RETARDATION PROTEIN
1

(Homo sapiens) 		PF05641
(Agenet) 		3 PRO A  76
GLU A   7
TYR A  16
 None
 0.79A 2zmbA-4ovaA:
undetectable		 2zmbA-4ovaA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovy HALOACID
DEHALOGENASE DOMAIN
PROTEIN HYDROLASE

(Planctopirus
limnophila) 		PF12710
(HAD) 		3 PRO A 251
GLU A 266
TYR A 267
 None
 0.67A 2zmbA-4ovyA:
undetectable		 2zmbA-4ovyA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p55 VIRAL IRF2-LIKE
PROTEIN

(Human
gammaherpesvirus
8) 		PF00605
(IRF) 		3 PRO A  34
GLU A  51
TYR A  50
 None
 0.79A 2zmbA-4p55A:
undetectable		 2zmbA-4p55A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 PRO B 468
GLU A 816
TYR A 817
 None
 0.71A 2zmbA-4qiwB:
undetectable		 2zmbA-4qiwB:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uds MBDR REGULATOR

(Azoarcus sp.
CIB) 		PF00440
(TetR_N) 		3 PRO A 108
GLU A 179
TYR A 181
 None
 0.81A 2zmbA-4udsA:
undetectable		 2zmbA-4udsA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB

(Lactococcus
lactis) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		3 PRO A  10
GLU A 471
TYR A 475
 None
 0.58A 2zmbA-4wd9A:
undetectable		 2zmbA-4wd9A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgk NEUTRAL CERAMIDASE

(Homo sapiens) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		3 PRO A 501
GLU A 585
TYR A 586
 None
 0.67A 2zmbA-4wgkA:
undetectable		 2zmbA-4wgkA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wqo CULLIN-2

(Homo sapiens) 		PF00888
(Cullin) 		3 PRO D   5
GLU D  51
TYR D  49
 None
 0.76A 2zmbA-4wqoD:
undetectable		 2zmbA-4wqoD:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrw URACIL-DNA
GLYCOSYLASE

(Mycobacterium
tuberculosis) 		PF03167
(UDG) 		3 PRO A 110
GLU A 100
TYR A 101
 None
 0.76A 2zmbA-4wrwA:
undetectable		 2zmbA-4wrwA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8r TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		3 PRO A 211
GLU A  41
TYR A  37
 None
 0.78A 2zmbA-4x8rA:
2.7		 2zmbA-4x8rA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		3 PRO A 163
GLU A 160
TYR A 161
 None
 0.76A 2zmbA-4xgtA:
undetectable		 2zmbA-4xgtA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y97 DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF08996
(zf-DNA_Pol) 		3 PRO B1305
GLU B1402
TYR B1430
 None
 0.73A 2zmbA-4y97B:
undetectable		 2zmbA-4y97B:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus musculus) 		PF01370
(Epimerase) 		3 PRO A 300
GLU A 254
TYR A 318
 None
 0.75A 2zmbA-4yraA:
undetectable		 2zmbA-4yraA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du2 ESPG2
GLYCOSYLTRANSFERASE

(Actinomadura
verrucosospora) 		PF00201
(UDPGT) 		3 PRO A 125
GLU A 398
TYR A 394
 None
 0.60A 2zmbA-5du2A:
undetectable		 2zmbA-5du2A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e32 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 PRO A  58
GLU A 273
TYR A 274
 None
 0.60A 2zmbA-5e32A:
undetectable		 2zmbA-5e32A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3j RESPONSE REGULATOR
RSTA

(Acinetobacter
baumannii) 		PF00072
(Response_reg) 		3 PRO A 111
GLU A  25
TYR A  26
 None
 0.72A 2zmbA-5e3jA:
2.5		 2zmbA-5e3jA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elp NRPS/PKS PROTEIN

(Bacillus
amyloliquefaciens) 		no annotation 3 PRO C 588
GLU C 463
TYR C 464
 None
 0.77A 2zmbA-5elpC:
undetectable		 2zmbA-5elpC:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnd PUTATIVE SERINE
PROTEASE HHOA

(Synechocystis
sp. PCC 6803) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		3 PRO A 330
GLU A 361
TYR A 288
 None
 0.63A 2zmbA-5gndA:
undetectable		 2zmbA-5gndA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 3 PRO B 765
GLU B 775
TYR B 773
 None
 0.81A 2zmbA-5iz5B:
undetectable		 2zmbA-5iz5B:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		3 PRO A 514
GLU A 566
TYR A 567
 None
 0.73A 2zmbA-5n6uA:
undetectable		 2zmbA-5n6uA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4

(Homo sapiens) 		no annotation 3 PRO A 306
GLU A 221
TYR A 290
 PRO  A 306 ( 1.1A)
GLU  A 221 ( 0.6A)
TYR  A 290 ( 1.3A)
 0.79A 2zmbA-5nksA:
undetectable		 2zmbA-5nksA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5non S-NORCOCLAURINE
SYNTHASE

(Thalictrum
flavum) 		PF00407
(Bet_v_1) 		3 PRO A 105
GLU A 128
TYR A 108
 None
 0.73A 2zmbA-5nonA:
undetectable		 2zmbA-5nonA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 PRO A2527
GLU A2538
TYR A2537
 None
 0.71A 2zmbA-5nugA:
undetectable		 2zmbA-5nugA:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t87 CDIA TOXIN
CDII IMMUNITY
PROTEIN

(Cupriavidus
taiwanensis) 		no annotation 3 PRO E 170
GLU E 178
TYR A   5
 None
 0.79A 2zmbA-5t87E:
undetectable		 2zmbA-5t87E:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uus POSSIBLE
SORTASE-LIKE PROTEIN

(Corynebacterium
diphtheriae) 		PF04203
(Sortase) 		3 PRO A 219
GLU A 199
TYR A 198
 None
 0.80A 2zmbA-5uusA:
undetectable		 2zmbA-5uusA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42

(Saccharomyces
cerevisiae) 		no annotation 3 PRO G 254
GLU D 372
TYR D 375
 None
 0.81A 2zmbA-5uz5G:
undetectable		 2zmbA-5uz5G:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)

(Mycobacterium
tuberculosis) 		PF00975
(Thioesterase) 		3 PRO A1476
GLU A1485
TYR A1484
 None
 0.57A 2zmbA-5v41A:
undetectable		 2zmbA-5v41A:
21.17