SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZMA_A_ACAA502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 MET A 240
ALA A 239
SER A 247
ASN A 236
GLY A 212
 ADP  A4000 (-4.0A)
None
K  A4003 (-2.7A)
K  A4003 (-3.9A)
None
 1.42A 2zmaA-1c30A:
0.0		 2zmaA-1c30A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6s O-ACETYLSERINE
SULFHYDRYLASE

(Salmonella
enterica) 		PF00291
(PALP) 		5 ALA A  75
SER A  39
ASN A  71
GLY A  45
ILE A  44
 None
None
PLP  A 501 ( 3.9A)
None
None
 1.08A 2zmaA-1d6sA:
0.0		 2zmaA-1d6sA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 MET A 622
TYR A 635
SER A 461
GLY A 621
ILE A 640
 None
 1.19A 2zmaA-1r9jA:
0.0		 2zmaA-1r9jA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bjs ISOPENICILLIN N
SYNTHETASE

(Aspergillus
nidulans) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		5 MET A 257
TYR A 160
SER A  36
GLY A 254
ILE A 220
 None
 1.43A 2zmaA-2bjsA:
0.0		 2zmaA-2bjsA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		5 MET A 140
ASP A  26
ASN A  32
GLY A 216
ILE A 228
 None
 1.41A 2zmaA-2v9iA:
0.0		 2zmaA-2v9iA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk8 CAI-1 AUTOINDUCER
SYNTHASE

(Vibrio cholerae) 		PF00155
(Aminotran_1_2) 		5 ALA A 111
ASP A 173
SER A 135
ASN A 112
GLY A 243
 None
PLP  A 600 (-3.5A)
PLP  A 600 ( 3.8A)
PLP  A 600 ( 4.7A)
None
 1.36A 2zmaA-2wk8A:
0.0		 2zmaA-2wk8A:
22.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zm2 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Flavobacterium
sp.) 		PF00144
(Beta-lactamase) 		6 MET A 111
TRP A 186
TYR A 215
SER A 217
GLY A 344
ILE A 345
 MES  A 504 (-3.8A)
MES  A 504 (-4.0A)
GOL  A 505 ( 4.4A)
MES  A 504 ( 2.7A)
MES  A 501 (-3.5A)
MES  A 504 ( 3.7A)
 0.24A 2zmaA-2zm2A:
67.3		 2zmaA-2zm2A:
97.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 MET A 352
ALA A 351
PHE A 392
GLY A 329
ILE A 328
 None
 1.35A 2zmaA-3ce6A:
undetectable		 2zmaA-3ce6A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cih PUTATIVE
ALPHA-RHAMNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		5 MET A 322
TYR A 300
PHE A 330
GLY A 318
ILE A 629
 None
 1.35A 2zmaA-3cihA:
0.0		 2zmaA-3cihA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1

(Thermotoga
maritima) 		PF13507
(GATase_5) 		5 MET D 184
ALA D 171
SER D 166
ASN D 164
GLY D 172
 CYG  D  86 ( 3.4A)
None
None
None
None
 1.36A 2zmaA-3d54D:
undetectable		 2zmaA-3d54D:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 ALA A-118
ASP A -53
TYR A-139
ASN A-115
GLY A-121
 None
 1.28A 2zmaA-3ehsA:
undetectable		 2zmaA-3ehsA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eyx CARBONIC ANHYDRASE

(Saccharomyces
cerevisiae) 		PF00484
(Pro_CA) 		5 ALA A  81
TYR A 140
ASN A  82
GLY A 117
ILE A 144
 ACT  A 222 (-3.8A)
None
None
ACT  A 222 (-3.6A)
None
 1.48A 2zmaA-3eyxA:
undetectable		 2zmaA-3eyxA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grz RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE

(Lactobacillus
delbrueckii) 		PF06325
(PrmA) 		5 MET A 167
ALA A 166
ASN A 248
GLY A 169
ILE A 170
 None
 1.42A 2zmaA-3grzA:
undetectable		 2zmaA-3grzA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ALA A  21
TYR A 254
ASP A 359
GLY A  12
ILE A  11
 None
 1.35A 2zmaA-3o04A:
undetectable		 2zmaA-3o04A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr2 CYSTEINE SYNTHASE

(Mycobacterium
marinum) 		PF00291
(PALP) 		5 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 None
 1.18A 2zmaA-3rr2A:
undetectable		 2zmaA-3rr2A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Sorangium
cellulosum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A  57
ASP A 247
ASN A  59
GLY A  28
ILE A  25
 None
 1.29A 2zmaA-3s5sA:
undetectable		 2zmaA-3s5sA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0b OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 ALA A 367
PHE A 427
ASN A 382
GLY A 365
ILE A 364
 None
 1.37A 2zmaA-3u0bA:
undetectable		 2zmaA-3u0bA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1j SERINE PROTEASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7) 		5 ALA B 166
SER B 163
PHE B 116
GLY B 148
ILE B 139
 None
 1.48A 2zmaA-3u1jB:
undetectable		 2zmaA-3u1jB:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zei O-ACETYLSERINE
SULFHYDRYLASE

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		5 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 None
None
PLP  A1301 (-3.8A)
None
None
 1.13A 2zmaA-3zeiA:
undetectable		 2zmaA-3zeiA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha4 BETA-GALACTOSIDASE

(Acidilobus
saccharovorans) 		PF00232
(Glyco_hydro_1) 		5 ALA A  16
SER A  20
ASN A 428
GLY A  82
ILE A  81
 None
 1.28A 2zmaA-4ha4A:
undetectable		 2zmaA-4ha4A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyn CHEC, INHIBITOR OF
MCP METHYLATION /
FLIN FUSION PROTEIN

(Thermotoga
maritima) 		PF04509
(CheC) 		5 MET A 138
ALA A 141
TYR A  86
GLY A 139
ILE A 155
 None
 1.34A 2zmaA-4hynA:
undetectable		 2zmaA-4hynA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Conexibacter
woesei) 		PF13407
(Peripla_BP_4) 		5 ALA A 295
ASP A 137
PHE A 148
GLY A 292
ILE A  66
 None
GOL  A 502 (-2.8A)
GOL  A 503 ( 4.8A)
None
None
 1.28A 2zmaA-4kq9A:
undetectable		 2zmaA-4kq9A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li3 CYSTEINE SYNTHASE

(Haemophilus
influenzae) 		PF00291
(PALP) 		5 ALA X  76
SER X  40
ASN X  72
GLY X  46
ILE X  45
 LLP  X  42 ( 3.2A)
LLP  X  42 ( 3.0A)
LLP  X  42 ( 3.8A)
LLP  X  42 ( 3.7A)
LLP  X  42 ( 4.0A)
 1.04A 2zmaA-4li3X:
undetectable		 2zmaA-4li3X:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lma CYSTEINE SYNTHASE

(Microcystis
aeruginosa) 		PF00291
(PALP) 		5 ALA A  81
SER A  44
ASN A  77
GLY A  50
ILE A  49
 None
PLP  A 403 ( 4.7A)
PLP  A 403 (-3.9A)
None
None
 1.07A 2zmaA-4lmaA:
undetectable		 2zmaA-4lmaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmb CYSTEINE SYNTHASE

(Microcystis
aeruginosa) 		PF00291
(PALP) 		5 ALA A  81
SER A  44
ASN A  77
GLY A  50
ILE A  49
 None
None
PLP  A 403 ( 3.7A)
None
None
 1.10A 2zmaA-4lmbA:
undetectable		 2zmaA-4lmbA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6y AMINOPEPTIDASE

(Thermotoga
maritima) 		PF05343
(Peptidase_M42) 		5 TYR A 287
SER A 194
ASN A  43
GLY A 191
ILE A  56
 None
 1.31A 2zmaA-4p6yA:
undetectable		 2zmaA-4p6yA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf8 TRAP-T FAMILY
TRANSPORTER, DCTP
(PERIPLASMIC
BINDING) SUBUNIT

(Sulfitobacter
sp. NAS-14.1) 		PF03480
(DctP) 		5 ALA A 206
PHE A 191
ASN A 208
GLY A 205
ILE A 198
 None
GTR  A 402 ( 3.7A)
GTR  A 402 (-2.9A)
None
None
 1.33A 2zmaA-4pf8A:
undetectable		 2zmaA-4pf8A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqk MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
TRUNCATED
REPLICATION PROTEIN
REPA

(Escherichia
coli;
Staphylococcus
aureus) 		PF13416
(SBP_bac_8) 		5 ALA A 232
ASP A 297
TYR A 211
ASN A 235
GLY A 229
 None
 1.30A 2zmaA-4pqkA:
undetectable		 2zmaA-4pqkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00342
(PGI) 		5 MET A 489
ASP A 103
TYR A 381
GLY A 524
ILE A  72
 None
 1.36A 2zmaA-4qfhA:
undetectable		 2zmaA-4qfhA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qt4 PEPTIDYL-TRNA
HYDROLASE

(Streptococcus
pyogenes) 		PF01195
(Pept_tRNA_hydro) 		5 MET A  25
ALA A  26
ASN A  29
GLY A  23
ILE A  22
 None
 1.04A 2zmaA-4qt4A:
undetectable		 2zmaA-4qt4A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA

(Escherichia
coli;
Mycobacterium
tuberculosis) 		PF01648
(ACPS)
PF13416
(SBP_bac_8) 		5 ALA A 232
ASP A 297
TYR A 211
ASN A 235
GLY A 229
 None
 1.29A 2zmaA-4qvhA:
undetectable		 2zmaA-4qvhA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udn PERIPLASMIC SOLUTE
BINDING PROTEIN

(Candidatus
Liberibacter
asiaticus) 		PF01297
(ZnuA) 		5 MET A 115
ALA A 114
TYR A 143
TYR A 259
ILE A 118
 None
 1.13A 2zmaA-4udnA:
undetectable		 2zmaA-4udnA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		5 ALA A  57
PHE A 274
ASN A 291
GLY A 347
ILE A  59
 None
 1.45A 2zmaA-5cerA:
11.9		 2zmaA-5cerA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxo EPOXIDE HYDROLASE

(Streptomyces
albus) 		PF12680
(SnoaL_2) 		5 MET A  87
ALA A  61
ASP A  38
SER A  57
ASN A  58
 P6G  A 202 (-3.1A)
None
P6G  A 202 (-3.8A)
P6G  A 202 (-3.2A)
P6G  A 202 (-3.2A)
 1.08A 2zmaA-5cxoA:
undetectable		 2zmaA-5cxoA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19

(Escherichia
coli;
Tetrahymena
thermophila) 		PF13416
(SBP_bac_8) 		5 ALA A 231
ASP A 296
TYR A 210
ASN A 234
GLY A 228
 None
 1.27A 2zmaA-5dfmA:
undetectable		 2zmaA-5dfmA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jj4 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SINGLE-STRAN
DED DNA CYTOSINE
DEAMINASE

(Escherichia
coli;
Homo sapiens) 		no annotation 5 ALA C 231
ASP C 296
TYR C 210
ASN C 234
GLY C 228
 None
 1.30A 2zmaA-5jj4C:
undetectable		 2zmaA-5jj4C:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		5 TYR A 155
TRP A 236
SER A 109
GLY A 147
ILE A 146
 None
 1.26A 2zmaA-5lrbA:
undetectable		 2zmaA-5lrbA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m11 IMMUNOREACTIVE 84KD
ANTIGEN PG93

(Porphyromonas
gingivalis) 		no annotation 5 MET A 554
ALA A 553
ASN A 490
GLY A 565
ILE A 551
 None
None
ZN  A 805 ( 4.8A)
None
None
 1.40A 2zmaA-5m11A:
undetectable		 2zmaA-5m11A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuf TETRACYCLINE
DESTRUCTASE TET(50)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 ALA A 291
TYR A 330
PHE A 167
GLY A 288
ILE A 287
 None
None
None
FAD  A 405 (-3.2A)
None
 1.31A 2zmaA-5tufA:
undetectable		 2zmaA-5tufA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ud6 DIHYDRODIPICOLINATE
SYNTHASE

(Cyanidioschyzon
merolae) 		no annotation 5 TYR A 145
PHE A 258
ASN A 262
GLY A 149
ILE A 147
 KPI  A 174 ( 3.7A)
None
None
None
None
 1.50A 2zmaA-5ud6A:
undetectable		 2zmaA-5ud6A:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugz PUTATIVE
THIOESTERASE

(Escherichia
coli) 		PF00975
(Thioesterase) 		5 TYR A 165
ASP A 111
PHE A 200
GLY A  81
ILE A  82
 None
 1.44A 2zmaA-5ugzA:
undetectable		 2zmaA-5ugzA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa2 CYSTEINE SYNTHASE

(Planctopirus
limnophila) 		PF00291
(PALP) 		5 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 LLP  A  44 ( 3.2A)
LLP  A  44 ( 3.1A)
LLP  A  44 ( 3.8A)
LLP  A  44 ( 3.7A)
LLP  A  44 ( 4.1A)
 1.14A 2zmaA-5xa2A:
undetectable		 2zmaA-5xa2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER

(Homo sapiens) 		no annotation 5 MET A1808
TYR A1701
PHE A1766
GLY A1809
ILE A1811
 None
 1.39A 2zmaA-5zalA:
undetectable		 2zmaA-5zalA:
11.48