SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZM9_A_ACAA502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8s CHLOROPEROXIDASE F

(Pseudomonas
fluorescens)
PF00561
(Abhydrolase_1)
4 ALA A 193
TYR A 155
HIS A 190
ILE A 197
None
0.83A 2zm9A-1a8sA:
0.0
2zm9A-1a8sA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)


(Escherichia
coli)
PF00117
(GATase)
PF00988
(CPSase_sm_chain)
4 ALA B1577
HIS B1576
GLY B1579
ILE B1607
None
0.83A 2zm9A-1a9xB:
0.0
2zm9A-1a9xB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Escherichia
coli)
PF00155
(Aminotran_1_2)
4 ALA A  84
TYR A 113
GLY A  87
ILE A  88
PPE  A 413 (-3.7A)
None
None
None
0.88A 2zm9A-1geyA:
0.0
2zm9A-1geyA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i17 PRION-LIKE PROTEIN

(Mus musculus)
PF00377
(Prion)
4 ALA A  62
TRP A  86
GLY A   8
ILE A  40
None
0.85A 2zm9A-1i17A:
undetectable
2zm9A-1i17A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvl DIHYDROLIPOAMIDE
DEHYDROGENASE


(Pseudomonas
putida)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 MET A 317
ALA A 316
HIS A 314
GLY A  16
None
FAD  A 459 ( 3.7A)
FAD  A 459 (-4.0A)
FAD  A 459 (-3.8A)
0.91A 2zm9A-1lvlA:
0.0
2zm9A-1lvlA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))


(Sulfolobus
solfataricus)
PF00117
(GATase)
4 MET B 160
ALA B 161
TYR B 123
ILE B 112
None
0.87A 2zm9A-1qdlB:
0.0
2zm9A-1qdlB:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT


(Methanocaldococcus
jannaschii)
PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C)
4 ALA A 264
TYR A  79
GLY A 263
ILE A 318
None
0.85A 2zm9A-1s0uA:
0.0
2zm9A-1s0uA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spg HEMOGLOBIN

(Leiostomus
xanthurus)
PF00042
(Globin)
4 MET A  65
ALA A  62
TRP A  14
GLY A  61
None
0.92A 2zm9A-1spgA:
undetectable
2zm9A-1spgA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sus CAFFEOYL-COA
O-METHYLTRANSFERASE


(Medicago sativa)
PF01596
(Methyltransf_3)
4 MET A 110
TYR A 172
GLY A  87
ILE A  86
None
None
SAH  A 301 (-3.4A)
None
0.80A 2zm9A-1susA:
0.0
2zm9A-1susA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT


(Saccharomyces
cerevisiae)
PF00004
(AAA)
PF08542
(Rep_fac_C)
4 TRP B 257
TYR C 149
GLY B 302
ILE B 299
None
0.82A 2zm9A-1sxjB:
0.0
2zm9A-1sxjB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkd ISOCITRATE
DEHYDROGENASE


(Aeropyrum
pernix)
PF00180
(Iso_dh)
4 MET A 372
TYR A  66
GLY A 369
ILE A 368
None
0.81A 2zm9A-1xkdA:
undetectable
2zm9A-1xkdA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE


(Streptococcus
pneumoniae)
PF01048
(PNP_UDP_1)
4 MET A   9
ALA A   8
GLY A  49
ILE A  50
MTM  A 301 ( 4.6A)
MTM  A 301 (-3.4A)
None
MTM  A 301 (-4.0A)
0.91A 2zm9A-1zosA:
undetectable
2zm9A-1zosA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a87 THIOREDOXIN
REDUCTASE


(Mycobacterium
tuberculosis)
PF07992
(Pyr_redox_2)
4 MET A 122
ALA A 121
GLY A  21
ILE A  20
None
None
FAD  A 348 (-3.1A)
None
0.82A 2zm9A-2a87A:
undetectable
2zm9A-2a87A:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejv L-THREONINE
3-DEHYDROGENASE


(Thermus
thermophilus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 MET A 179
ALA A 180
GLY A 177
ILE A 176
None
None
None
NAD  A1350 (-3.9A)
0.63A 2zm9A-2ejvA:
undetectable
2zm9A-2ejvA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2euh NADP DEPENDENT NON
PHOSPHORYLATING
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE


(Streptococcus
mutans)
PF00171
(Aldedh)
4 MET A 241
ALA A 242
GLY A 239
ILE A 238
None
0.79A 2zm9A-2euhA:
undetectable
2zm9A-2euhA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E


(Thermotoga
maritima)
PF04204
(HTS)
4 TYR A 237
HIS A 190
GLY A 107
ILE A 141
None
0.88A 2zm9A-2h2wA:
undetectable
2zm9A-2h2wA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzi SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM


(Homo sapiens)
no annotation 4 MET B  16
ALA B  17
GLY B  14
ILE B  13
None
0.81A 2zm9A-2jziB:
undetectable
2zm9A-2jziB:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n4x CYTOCHROME C-TYPE
BIOGENESIS PROTEIN
(CCDA)


(Archaeoglobus
fulgidus)
no annotation 4 ALA A 123
TYR A 142
GLY A 124
ILE A 127
None
0.91A 2zm9A-2n4xA:
undetectable
2zm9A-2n4xA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ock VALACYCLOVIR
HYDROLASE


(Homo sapiens)
PF00561
(Abhydrolase_1)
4 ALA A 147
HIS A 234
GLY A 125
ILE A 126
None
0.86A 2zm9A-2ockA:
undetectable
2zm9A-2ockA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opk HYPOTHETICAL PROTEIN

(Cupriavidus
pinatubonensis)
PF07883
(Cupin_2)
4 MET A  76
ALA A  63
GLY A  64
ILE A  65
None
0.82A 2zm9A-2opkA:
undetectable
2zm9A-2opkA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA


(Desulfovibrio
vulgaris)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
4 MET A 341
ALA A 331
GLY A 342
ILE A 229
None
0.91A 2zm9A-2v4jA:
undetectable
2zm9A-2v4jA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE


(Escherichia
coli)
PF00596
(Aldolase_II)
4 ALA A 120
HIS A 141
GLY A 194
ILE A 193
None
ZN  A1275 (-3.2A)
None
None
0.87A 2zm9A-2v9iA:
undetectable
2zm9A-2v9iA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhq NTPASE P4

(Pseudomonas
phage phi12)
PF11602
(NTPase_P4)
4 MET A 221
ALA A 222
GLY A 219
ILE A 218
None
0.58A 2zm9A-2vhqA:
undetectable
2zm9A-2vhqA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xla SLL1785 PROTEIN

(Synechocystis
sp. PCC 6803)
no annotation 4 MET A 195
TRP A 125
GLY A 100
ILE A  99
None
0.87A 2zm9A-2xlaA:
undetectable
2zm9A-2xlaA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtp GTPASE IMAP FAMILY
MEMBER 2


(Homo sapiens)
PF04548
(AIG1)
4 ALA A 137
TYR A 219
HIS A 140
GLY A 134
None
0.88A 2zm9A-2xtpA:
undetectable
2zm9A-2xtpA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y35 LD22664P

(Drosophila
melanogaster)
PF03159
(XRN_N)
5 MET A 743
TYR A 254
HIS A 699
GLY A 744
ILE A 745
None
1.46A 2zm9A-2y35A:
undetectable
2zm9A-2y35A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM


(Mus musculus)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
4 ALA A 735
TYR A 772
HIS A 737
ILE A 720
None
0.84A 2zm9A-2y3aA:
undetectable
2zm9A-2y3aA:
15.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zm2 6-AMINOHEXANOATE-DIM
ER HYDROLASE


(Flavobacterium
sp.)
PF00144
(Beta-lactamase)
6 MET A 111
TRP A 186
TYR A 215
HIS A 266
GLY A 344
ILE A 345
MES  A 504 (-3.8A)
MES  A 504 (-4.0A)
GOL  A 505 ( 4.4A)
MES  A 504 (-4.0A)
MES  A 501 (-3.5A)
MES  A 504 ( 3.7A)
0.16A 2zm9A-2zm2A:
68.2
2zm9A-2zm2A:
99.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE


(Thermococcus
kodakarensis)
PF00082
(Peptidase_S8)
PF04151
(PPC)
4 MET A 202
ALA A 203
GLY A 367
ILE A 368
None
0.81A 2zm9A-3afgA:
undetectable
2zm9A-3afgA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE


(Mesorhizobium
japonicum)
PF01494
(FAD_binding_3)
4 ALA A  17
HIS A  40
GLY A 154
ILE A 152
FAD  A 380 ( 4.5A)
None
None
None
0.76A 2zm9A-3allA:
undetectable
2zm9A-3allA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbl REGULATORY PROTEIN
OF LACI FAMILY


(Chloroflexus
aggregans)
PF13377
(Peripla_BP_3)
4 MET A 263
ALA A 264
GLY A 261
ILE A 260
EDO  A 503 (-4.5A)
EDO  A 503 (-3.7A)
None
None
0.58A 2zm9A-3bblA:
undetectable
2zm9A-3bblA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg2 DGTP
TRIPHOSPHOHYDROLASE


(Leeuwenhoekiella
blandensis)
PF01966
(HD)
4 ALA A 371
TYR A 435
GLY A 372
ILE A 375
None
0.92A 2zm9A-3bg2A:
undetectable
2zm9A-3bg2A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxp PUTATIVE
LIPASE/ESTERASE


(Lactobacillus
plantarum)
PF07859
(Abhydrolase_3)
4 ALA A 117
TYR A  72
HIS A 120
GLY A  44
None
0.73A 2zm9A-3bxpA:
undetectable
2zm9A-3bxpA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpi RAB GDP-DISSOCIATION
INHIBITOR


(Saccharomyces
cerevisiae)
PF00996
(GDI)
4 MET G 197
ALA G 198
GLY G 194
ILE G 193
None
0.61A 2zm9A-3cpiG:
undetectable
2zm9A-3cpiG:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmb PUTATIVE GENERAL
STRESS PROTEIN 26
WITH A PNP-OXIDASE
LIKE FOLD


(Xanthomonas
campestris)
PF16242
(Pyrid_ox_like)
4 ALA A  71
TRP A 130
GLY A  70
ILE A  69
None
0.86A 2zm9A-3dmbA:
undetectable
2zm9A-3dmbA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e77 PHOSPHOSERINE
AMINOTRANSFERASE


(Homo sapiens)
PF00266
(Aminotran_5)
4 MET A 267
ALA A 264
GLY A 263
ILE A 258
None
0.82A 2zm9A-3e77A:
undetectable
2zm9A-3e77A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbs OXIDOREDUCTASE

(Agrobacterium
fabrum)
PF07992
(Pyr_redox_2)
4 MET A 108
ALA A 107
GLY A   9
ILE A   8
None
None
FAD  A 298 (-3.4A)
None
0.84A 2zm9A-3fbsA:
undetectable
2zm9A-3fbsA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flb RIFR

(Amycolatopsis
mediterranei)
PF00975
(Thioesterase)
4 TYR A 180
HIS A 214
GLY A 100
ILE A  98
None
0.90A 2zm9A-3flbA:
undetectable
2zm9A-3flbA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hh8 METAL ABC
TRANSPORTER
SUBSTRATE-BINDING
LIPOPROTEIN


(Streptococcus
pyogenes)
PF01297
(ZnuA)
4 MET A 295
ALA A 294
GLY A 289
ILE A 282
None
0.78A 2zm9A-3hh8A:
undetectable
2zm9A-3hh8A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER


(Rhodospirillum
rubrum)
PF13458
(Peripla_BP_6)
4 MET A 238
ALA A 237
GLY A 182
ILE A 181
None
0.90A 2zm9A-3hutA:
undetectable
2zm9A-3hutA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib5 SEX PHEROMONE
PRECURSOR


(Lactobacillus
salivarius)
PF07537
(CamS)
5 MET A 227
ALA A 226
TRP A 256
GLY A 171
ILE A 172
None
1.49A 2zm9A-3ib5A:
undetectable
2zm9A-3ib5A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ism CG8862

(Drosophila
melanogaster)
PF01223
(Endonuclease_NS)
4 MET A  77
TRP A 106
GLY A  74
ILE A  73
None
0.89A 2zm9A-3ismA:
undetectable
2zm9A-3ismA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m49 TRANSKETOLASE

(Bacillus
anthracis)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
4 MET A 334
ALA A 333
TYR A 139
GLY A 427
None
0.79A 2zm9A-3m49A:
undetectable
2zm9A-3m49A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxl GLUCARATE
DEHYDRATASE


(Burkholderia
lata)
PF13378
(MR_MLE_C)
4 TYR A 184
HIS A  36
GLY A 175
ILE A 174
None
CO3  A 477 (-4.0A)
None
None
0.82A 2zm9A-3nxlA:
undetectable
2zm9A-3nxlA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbt INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
RAS-RELATED PROTEIN
RAB-8A


(Homo sapiens)
PF00071
(Ras)
no annotation
4 TYR A  77
HIS B 660
GLY A  42
ILE A  43
None
None
SO4  B   1 ( 4.2A)
None
0.65A 2zm9A-3qbtA:
undetectable
2zm9A-3qbtA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qe7 URACIL PERMEASE

(Escherichia
coli)
PF00860
(Xan_ur_permease)
4 MET A 295
ALA A 296
GLY A 293
ILE A 292
None
0.68A 2zm9A-3qe7A:
undetectable
2zm9A-3qe7A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlv GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 5


(Rattus
norvegicus)
PF01094
(ANF_receptor)
4 MET A 380
ALA A 379
GLY A 370
ILE A 369
None
0.59A 2zm9A-3qlvA:
undetectable
2zm9A-3qlvA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp7 FLAVOPROTEIN
MONOOXYGENASE


(Klebsiella
pneumoniae)
PF01494
(FAD_binding_3)
4 MET A 302
ALA A 301
GLY A  11
ILE A  10
None
FAD  A 385 ( 4.5A)
FAD  A 385 (-3.5A)
FAD  A 385 (-4.1A)
0.89A 2zm9A-3rp7A:
undetectable
2zm9A-3rp7A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t33 G PROTEIN COUPLED
RECEPTOR


(Arabidopsis
thaliana)
PF05147
(LANC_like)
4 MET A 390
ALA A 391
GLY A 388
ILE A 387
None
0.72A 2zm9A-3t33A:
undetectable
2zm9A-3t33A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0n MRUBY

(Entacmaea
quadricolor)
PF01353
(GFP)
4 ALA A 222
TYR A 148
GLY A 226
ILE A 192
None
0.92A 2zm9A-3u0nA:
undetectable
2zm9A-3u0nA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u34 GENERAL STRESS
PROTEIN


(Xanthomonas
citri)
PF16242
(Pyrid_ox_like)
4 ALA A  91
TRP A 150
GLY A  90
ILE A  89
PGE  A 183 (-4.3A)
None
None
None
0.90A 2zm9A-3u34A:
undetectable
2zm9A-3u34A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vco DIHYDROFOLATE
REDUCTASE


(Schistosoma
mansoni)
PF00186
(DHFR_1)
4 ALA A   8
TYR A 117
GLY A  16
ILE A  15
None
0.91A 2zm9A-3vcoA:
undetectable
2zm9A-3vcoA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE


(Methanothermobacter
thermautotrophicus)
PF02374
(ArsA_ATPase)
4 MET A 179
ALA A 180
GLY A 177
ILE A 176
None
0.66A 2zm9A-3zq6A:
undetectable
2zm9A-3zq6A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM


(Mus musculus)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
4 ALA A 735
TYR A 772
HIS A 737
ILE A 720
None
0.88A 2zm9A-4bfrA:
undetectable
2zm9A-4bfrA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115


(Bacteroides
ovatus)
PF15979
(Glyco_hydro_115)
4 MET A 279
ALA A 280
GLY A 312
ILE A 313
None
0.58A 2zm9A-4c90A:
undetectable
2zm9A-4c90A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8t GLUCARATE
DEHYDRATASE


(Actinobacillus
succinogenes)
PF13378
(MR_MLE_C)
4 TYR A 160
HIS A  28
GLY A 151
ILE A 150
None
SO4  A 501 (-4.2A)
None
None
0.84A 2zm9A-4g8tA:
undetectable
2zm9A-4g8tA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE


(Saccharomyces
cerevisiae)
PF07992
(Pyr_redox_2)
4 ALA A 396
HIS A 397
GLY A 382
ILE A 381
ALA  A 396 (-0.0A)
HIS  A 397 ( 1.0A)
GLY  A 382 (-0.0A)
ILE  A 381 ( 0.7A)
0.79A 2zm9A-4g9kA:
undetectable
2zm9A-4g9kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gm6 PFKB FAMILY
CARBOHYDRATE KINASE


(Listeria grayi)
PF00294
(PfkB)
4 MET A  64
ALA A  65
GLY A  62
ILE A  61
None
0.73A 2zm9A-4gm6A:
undetectable
2zm9A-4gm6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN


(Escherichia
coli)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 TYR C 163
HIS C  31
GLY C 154
ILE C 153
None
CIT  C 501 (-3.9A)
None
None
0.87A 2zm9A-4gypC:
undetectable
2zm9A-4gypC:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12


(Thermus
thermophilus)
PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N)
4 ALA L 213
TYR L 260
GLY L 249
ILE L 253
None
0.86A 2zm9A-4heaL:
undetectable
2zm9A-4heaL:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn8 D-GLUCARATE
DEHYDRATASE


(Pseudomonas
mendocina)
PF13378
(MR_MLE_C)
4 TYR A 181
HIS A  34
GLY A 172
ILE A 171
None
GOL  A 502 (-4.3A)
None
None
0.81A 2zm9A-4hn8A:
undetectable
2zm9A-4hn8A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyn CHEC, INHIBITOR OF
MCP METHYLATION /
FLIN FUSION PROTEIN


(Thermotoga
maritima)
PF04509
(CheC)
5 MET A 138
ALA A 141
TYR A  86
GLY A 139
ILE A 155
None
1.35A 2zm9A-4hynA:
undetectable
2zm9A-4hynA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igo OS05G0196500 PROTEIN

(Oryza sativa)
PF02373
(JmjC)
PF02375
(JmjN)
4 ALA A 480
TRP A 393
GLY A 182
ILE A 183
None
0.67A 2zm9A-4igoA:
undetectable
2zm9A-4igoA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il5 CYSTEINE SYNTHASE

(Entamoeba
histolytica)
PF00291
(PALP)
4 MET A 265
ALA A 266
GLY A 282
ILE A 285
None
0.66A 2zm9A-4il5A:
undetectable
2zm9A-4il5A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o87 N-TAGGED NUCLEASE

(Millerozyma
acaciae)
no annotation 4 MET A  15
ALA A  16
GLY A  13
ILE A  12
None
0.62A 2zm9A-4o87A:
undetectable
2zm9A-4o87A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oa7 TANKYRASE-1

(Homo sapiens)
PF00644
(PARP)
4 ALA A1138
TYR A1224
HIS A1132
GLY A1230
None
2XS  A1402 ( 3.9A)
None
None
0.85A 2zm9A-4oa7A:
undetectable
2zm9A-4oa7A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovt TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Ochrobactrum
anthropi)
PF03480
(DctP)
4 MET A  80
ALA A  79
GLY A 241
ILE A 137
None
0.79A 2zm9A-4ovtA:
undetectable
2zm9A-4ovtA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3k MGS-M1

(unidentified)
PF00326
(Peptidase_S9)
PF07859
(Abhydrolase_3)
4 ALA A 114
TYR A  71
HIS A 117
GLY A  43
F  A 302 (-3.6A)
None
None
F  A 302 (-3.4A)
0.88A 2zm9A-4q3kA:
undetectable
2zm9A-4q3kA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qt4 PEPTIDYL-TRNA
HYDROLASE


(Streptococcus
pyogenes)
PF01195
(Pept_tRNA_hydro)
4 MET A  25
ALA A  26
GLY A  23
ILE A  22
None
0.63A 2zm9A-4qt4A:
undetectable
2zm9A-4qt4A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udn PERIPLASMIC SOLUTE
BINDING PROTEIN


(Candidatus
Liberibacter
asiaticus)
PF01297
(ZnuA)
5 MET A 115
ALA A 114
TYR A 143
TYR A 259
ILE A 118
None
1.12A 2zm9A-4udnA:
undetectable
2zm9A-4udnA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v0p MELANOMA-ASSOCIATED
ANTIGEN 3


(Homo sapiens)
PF01454
(MAGE)
4 ALA A 199
TYR A 124
GLY A 163
ILE A 164
None
0.87A 2zm9A-4v0pA:
undetectable
2zm9A-4v0pA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpc RHO
GTPASE-ACTIVATING
PROTEIN RGD1


(Saccharomyces
cerevisiae)
no annotation 4 MET A 112
ALA A 113
HIS A  76
GLY A 110
None
0.90A 2zm9A-4wpcA:
undetectable
2zm9A-4wpcA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER


(Escherichia
coli)
PF01554
(MatE)
4 MET A 289
ALA A 288
TYR A 277
TYR A 436
None
None
OLC  A 501 (-3.6A)
None
0.80A 2zm9A-4z3nA:
undetectable
2zm9A-4z3nA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7r COENZYME PQQ
SYNTHESIS PROTEIN B


(Methylobacterium
extorquens)
PF12706
(Lactamase_B_2)
4 ALA A 197
HIS A 240
GLY A 172
ILE A 171
None
0.83A 2zm9A-4z7rA:
undetectable
2zm9A-4z7rA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a9a POLYHEDRIN

(Simulium
ubiquitum
cypovirus)
PF17515
(CPV_Polyhedrin)
4 TYR A 225
TYR A  47
GLY A 212
ILE A 215
None
0.90A 2zm9A-5a9aA:
undetectable
2zm9A-5a9aA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ams RIBOSOME ASSEMBLY
PROTEIN SQT1


(Saccharomyces
cerevisiae)
no annotation 4 ALA A 148
HIS A 136
GLY A 189
ILE A 184
None
0.91A 2zm9A-5amsA:
undetectable
2zm9A-5amsA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7w SERRALYSIN

(Serratia
marcescens)
PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C)
4 ALA A 240
TRP A  96
GLY A  36
ILE A  39
ALA  A 240 ( 0.0A)
TRP  A  96 ( 0.5A)
GLY  A  36 ( 0.0A)
ILE  A  39 ( 0.7A)
0.90A 2zm9A-5d7wA:
undetectable
2zm9A-5d7wA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwj HISTONE DEMETHYLASE
JARID1C


(Homo sapiens)
PF02373
(JmjC)
PF02375
(JmjN)
PF02928
(zf-C5HC2)
4 ALA A 600
TRP A 513
GLY A  42
ILE A  43
None
0.68A 2zm9A-5fwjA:
undetectable
2zm9A-5fwjA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1


(Saccharomyces
cerevisiae)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
4 ALA A1440
HIS A 851
GLY A1439
ILE A1436
None
0.71A 2zm9A-5ip9A:
undetectable
2zm9A-5ip9A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iqk BETA-LACTAMASE RM3

(uncultured
bacterium)
PF00753
(Lactamase_B)
4 ALA A 114
HIS A 108
GLY A 115
ILE A 111
None
ZN  A 401 (-3.2A)
None
None
0.89A 2zm9A-5iqkA:
undetectable
2zm9A-5iqkA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kia L-THREONINE
3-DEHYDROGENASE


(Burkholderia
thailandensis)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 MET A 178
ALA A 179
GLY A 176
ILE A 175
None
0.69A 2zm9A-5kiaA:
undetectable
2zm9A-5kiaA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kp7 CURD

(Moorea
producens)
PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C)
4 ALA A  43
TYR A  54
GLY A 169
ILE A 297
None
0.77A 2zm9A-5kp7A:
undetectable
2zm9A-5kp7A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kva CAFFEOYL-COA
O-METHYLTRANSFERASE


(Sorghum bicolor)
PF01596
(Methyltransf_3)
4 MET A 124
TYR A 186
GLY A 101
ILE A 100
None
None
SAM  A 301 (-3.4A)
None
0.73A 2zm9A-5kvaA:
undetectable
2zm9A-5kvaA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l94 CYTOCHROME P450

(Bacillus
megaterium)
PF00067
(p450)
4 ALA A  79
TYR A 199
GLY A 234
ILE A 237
None
0.79A 2zm9A-5l94A:
undetectable
2zm9A-5l94A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ld5 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE


(Atopobium
vaginae)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
4 ALA A 129
HIS A  98
GLY A 130
ILE A 127
None
0.92A 2zm9A-5ld5A:
undetectable
2zm9A-5ld5A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr6 XIAF PROTEIN

(Streptomyces
sp.)
PF08028
(Acyl-CoA_dh_2)
4 MET A 240
ALA A 241
HIS A 371
ILE A 237
GOL  A 602 (-3.7A)
None
FAD  A 601 (-3.8A)
GOL  A 602 ( 4.2A)
0.77A 2zm9A-5mr6A:
undetectable
2zm9A-5mr6A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrv CARBOXYPEPTIDASE O

(Homo sapiens)
no annotation 4 ALA A 197
TRP A  82
GLY A  57
ILE A  65
None
0.81A 2zm9A-5mrvA:
undetectable
2zm9A-5mrvA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2


(Leishmania
infantum)
no annotation 4 ALA A  46
HIS A 106
GLY A  47
ILE A  48
None
0.84A 2zm9A-5ol0A:
undetectable
2zm9A-5ol0A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT


(Xanthobacter
autotrophicus)
PF02538
(Hydantoinase_B)
4 ALA A  97
TYR A 265
GLY A 168
ILE A 167
None
0.91A 2zm9A-5svcA:
undetectable
2zm9A-5svcA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uth THIOREDOXIN
REDUCTASE


(Mycolicibacterium
smegmatis)
PF07992
(Pyr_redox_2)
4 MET A 114
ALA A 113
GLY A  14
ILE A  13
None
None
FAD  A 400 (-3.1A)
FAD  A 400 (-4.7A)
0.86A 2zm9A-5uthA:
undetectable
2zm9A-5uthA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uti QUEUINE
TRNA-RIBOSYLTRANSFER
ASE


(Zymomonas
mobilis)
no annotation 4 MET A 346
ALA A 343
GLY A 342
ILE A 335
None
0.91A 2zm9A-5utiA:
undetectable
2zm9A-5utiA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA


(Yersinia pestis)
PF01297
(ZnuA)
4 ALA A 149
TYR A 178
TYR A 294
ILE A 153
None
0.91A 2zm9A-5uygA:
undetectable
2zm9A-5uygA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v44 SACSIN

(Homo sapiens)
no annotation 4 TYR A 157
TYR A 138
GLY A 252
ILE A 253
None
None
None
GOL  A 403 (-4.6A)
0.88A 2zm9A-5v44A:
undetectable
2zm9A-5v44A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A


(Homo sapiens)
PF00628
(PHD)
PF01388
(ARID)
PF02373
(JmjC)
PF02375
(JmjN)
PF02928
(zf-C5HC2)
PF08429
(PLU-1)
4 ALA A 569
TRP A 482
GLY A  47
ILE A  48
None
0.62A 2zm9A-5v9pA:
undetectable
2zm9A-5v9pA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykn PROBABLE
LYSINE-SPECIFIC
DEMETHYLASE JMJ14


(Arabidopsis
thaliana)
no annotation 4 ALA A 395
TRP A 308
GLY A  84
ILE A  85
None
0.66A 2zm9A-5yknA:
undetectable
2zm9A-5yknA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN


(Homo sapiens)
no annotation 4 ALA A 569
TRP A 482
GLY A  47
ILE A  48
None
0.65A 2zm9A-6bgzA:
undetectable
2zm9A-6bgzA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3


(Saccharomyces
cerevisiae)
no annotation 5 MET A 267
ALA A 269
TYR A 243
HIS A 266
GLY A 271
EGY  A 803 (-4.6A)
None
None
None
EGY  A 803 ( 4.4A)
1.39A 2zm9A-6c26A:
undetectable
2zm9A-6c26A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B


(Homo sapiens)
no annotation 4 ALA A 585
TRP A 498
GLY A  60
ILE A  61
None
0.65A 2zm9A-6ek6A:
undetectable
2zm9A-6ek6A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epi ZETA_1 TOXIN

(Neisseria
gonorrhoeae)
no annotation 4 MET B 188
ALA B 189
GLY B 186
ILE B 185
None
None
SO4  B 503 ( 4.4A)
None
0.77A 2zm9A-6epiB:
undetectable
2zm9A-6epiB:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbc MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1


(Arabidopsis
thaliana)
no annotation 4 ALA A 178
TYR A  41
GLY A 175
ILE A 174
None
0.81A 2zm9A-6gbcA:
undetectable
2zm9A-6gbcA:
undetectable