SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZM9_A_ACAA502_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a8s | CHLOROPEROXIDASE F (Pseudomonasfluorescens) |
PF00561(Abhydrolase_1) | 4 | ALA A 193TYR A 155HIS A 190ILE A 197 | None | 0.83A | 2zm9A-1a8sA:0.0 | 2zm9A-1a8sA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a9x | CARBAMOYL PHOSPHATESYNTHETASE (SMALLCHAIN) (Escherichiacoli) |
PF00117(GATase)PF00988(CPSase_sm_chain) | 4 | ALA B1577HIS B1576GLY B1579ILE B1607 | None | 0.83A | 2zm9A-1a9xB:0.0 | 2zm9A-1a9xB:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gey | HISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Escherichiacoli) |
PF00155(Aminotran_1_2) | 4 | ALA A 84TYR A 113GLY A 87ILE A 88 | PPE A 413 (-3.7A)NoneNoneNone | 0.88A | 2zm9A-1geyA:0.0 | 2zm9A-1geyA:23.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i17 | PRION-LIKE PROTEIN (Mus musculus) |
PF00377(Prion) | 4 | ALA A 62TRP A 86GLY A 8ILE A 40 | None | 0.85A | 2zm9A-1i17A:undetectable | 2zm9A-1i17A:11.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lvl | DIHYDROLIPOAMIDEDEHYDROGENASE (Pseudomonasputida) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | MET A 317ALA A 316HIS A 314GLY A 16 | NoneFAD A 459 ( 3.7A)FAD A 459 (-4.0A)FAD A 459 (-3.8A) | 0.91A | 2zm9A-1lvlA:0.0 | 2zm9A-1lvlA:24.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qdl | PROTEIN(ANTHRANILATESYNTHASE(TRPG-SUBUNIT)) (Sulfolobussolfataricus) |
PF00117(GATase) | 4 | MET B 160ALA B 161TYR B 123ILE B 112 | None | 0.87A | 2zm9A-1qdlB:0.0 | 2zm9A-1qdlB:17.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s0u | TRANSLATIONINITIATION FACTOR 2GAMMA SUBUNIT (Methanocaldococcusjannaschii) |
PF00009(GTP_EFTU)PF03144(GTP_EFTU_D2)PF09173(eIF2_C) | 4 | ALA A 264TYR A 79GLY A 263ILE A 318 | None | 0.85A | 2zm9A-1s0uA:0.0 | 2zm9A-1s0uA:23.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1spg | HEMOGLOBIN (Leiostomusxanthurus) |
PF00042(Globin) | 4 | MET A 65ALA A 62TRP A 14GLY A 61 | None | 0.92A | 2zm9A-1spgA:undetectable | 2zm9A-1spgA:15.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sus | CAFFEOYL-COAO-METHYLTRANSFERASE (Medicago sativa) |
PF01596(Methyltransf_3) | 4 | MET A 110TYR A 172GLY A 87ILE A 86 | NoneNoneSAH A 301 (-3.4A)None | 0.80A | 2zm9A-1susA:0.0 | 2zm9A-1susA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sxj | ACTIVATOR 1 37 KDASUBUNITACTIVATOR 1 40 KDASUBUNIT (Saccharomycescerevisiae) |
PF00004(AAA)PF08542(Rep_fac_C) | 4 | TRP B 257TYR C 149GLY B 302ILE B 299 | None | 0.82A | 2zm9A-1sxjB:0.0 | 2zm9A-1sxjB:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xkd | ISOCITRATEDEHYDROGENASE (Aeropyrumpernix) |
PF00180(Iso_dh) | 4 | MET A 372TYR A 66GLY A 369ILE A 368 | None | 0.81A | 2zm9A-1xkdA:undetectable | 2zm9A-1xkdA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zos | 5'-METHYLTHIOADENOSINE /S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE (Streptococcuspneumoniae) |
PF01048(PNP_UDP_1) | 4 | MET A 9ALA A 8GLY A 49ILE A 50 | MTM A 301 ( 4.6A)MTM A 301 (-3.4A)NoneMTM A 301 (-4.0A) | 0.91A | 2zm9A-1zosA:undetectable | 2zm9A-1zosA:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a87 | THIOREDOXINREDUCTASE (Mycobacteriumtuberculosis) |
PF07992(Pyr_redox_2) | 4 | MET A 122ALA A 121GLY A 21ILE A 20 | NoneNoneFAD A 348 (-3.1A)None | 0.82A | 2zm9A-2a87A:undetectable | 2zm9A-2a87A:24.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ejv | L-THREONINE3-DEHYDROGENASE (Thermusthermophilus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | MET A 179ALA A 180GLY A 177ILE A 176 | NoneNoneNoneNAD A1350 (-3.9A) | 0.63A | 2zm9A-2ejvA:undetectable | 2zm9A-2ejvA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2euh | NADP DEPENDENT NONPHOSPHORYLATINGGLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Streptococcusmutans) |
PF00171(Aldedh) | 4 | MET A 241ALA A 242GLY A 239ILE A 238 | None | 0.79A | 2zm9A-2euhA:undetectable | 2zm9A-2euhA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h2w | HOMOSERINEO-SUCCINYLTRANSFERASE (Thermotogamaritima) |
PF04204(HTS) | 4 | TYR A 237HIS A 190GLY A 107ILE A 141 | None | 0.88A | 2zm9A-2h2wA:undetectable | 2zm9A-2h2wA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jzi | SERINE/THREONINE-PROTEIN PHOSPHATASE 2BCATALYTIC SUBUNITALPHA ISOFORM (Homo sapiens) |
no annotation | 4 | MET B 16ALA B 17GLY B 14ILE B 13 | None | 0.81A | 2zm9A-2jziB:undetectable | 2zm9A-2jziB:4.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2n4x | CYTOCHROME C-TYPEBIOGENESIS PROTEIN(CCDA) (Archaeoglobusfulgidus) |
no annotation | 4 | ALA A 123TYR A 142GLY A 124ILE A 127 | None | 0.91A | 2zm9A-2n4xA:undetectable | 2zm9A-2n4xA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ock | VALACYCLOVIRHYDROLASE (Homo sapiens) |
PF00561(Abhydrolase_1) | 4 | ALA A 147HIS A 234GLY A 125ILE A 126 | None | 0.86A | 2zm9A-2ockA:undetectable | 2zm9A-2ockA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2opk | HYPOTHETICAL PROTEIN (Cupriaviduspinatubonensis) |
PF07883(Cupin_2) | 4 | MET A 76ALA A 63GLY A 64ILE A 65 | None | 0.82A | 2zm9A-2opkA:undetectable | 2zm9A-2opkA:15.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v4j | SULFITE REDUCTASE,DISSIMILATORY-TYPESUBUNIT ALPHA (Desulfovibriovulgaris) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 4 | MET A 341ALA A 331GLY A 342ILE A 229 | None | 0.91A | 2zm9A-2v4jA:undetectable | 2zm9A-2v4jA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v9i | RHAMNULOSE-1-PHOSPHATE ALDOLASE (Escherichiacoli) |
PF00596(Aldolase_II) | 4 | ALA A 120HIS A 141GLY A 194ILE A 193 | None ZN A1275 (-3.2A)NoneNone | 0.87A | 2zm9A-2v9iA:undetectable | 2zm9A-2v9iA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vhq | NTPASE P4 (Pseudomonasphage phi12) |
PF11602(NTPase_P4) | 4 | MET A 221ALA A 222GLY A 219ILE A 218 | None | 0.58A | 2zm9A-2vhqA:undetectable | 2zm9A-2vhqA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xla | SLL1785 PROTEIN (Synechocystissp. PCC 6803) |
no annotation | 4 | MET A 195TRP A 125GLY A 100ILE A 99 | None | 0.87A | 2zm9A-2xlaA:undetectable | 2zm9A-2xlaA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xtp | GTPASE IMAP FAMILYMEMBER 2 (Homo sapiens) |
PF04548(AIG1) | 4 | ALA A 137TYR A 219HIS A 140GLY A 134 | None | 0.88A | 2zm9A-2xtpA:undetectable | 2zm9A-2xtpA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y35 | LD22664P (Drosophilamelanogaster) |
PF03159(XRN_N) | 5 | MET A 743TYR A 254HIS A 699GLY A 744ILE A 745 | None | 1.46A | 2zm9A-2y35A:undetectable | 2zm9A-2y35A:16.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y3a | PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE3-KINASE CATALYTICSUBUNIT BETA ISOFORM (Mus musculus) |
PF00454(PI3_PI4_kinase)PF00613(PI3Ka)PF00792(PI3K_C2)PF00794(PI3K_rbd)PF02192(PI3K_p85B) | 4 | ALA A 735TYR A 772HIS A 737ILE A 720 | None | 0.84A | 2zm9A-2y3aA:undetectable | 2zm9A-2y3aA:15.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zm2 | 6-AMINOHEXANOATE-DIMER HYDROLASE (Flavobacteriumsp.) |
PF00144(Beta-lactamase) | 6 | MET A 111TRP A 186TYR A 215HIS A 266GLY A 344ILE A 345 | MES A 504 (-3.8A)MES A 504 (-4.0A)GOL A 505 ( 4.4A)MES A 504 (-4.0A)MES A 501 (-3.5A)MES A 504 ( 3.7A) | 0.16A | 2zm9A-2zm2A:68.2 | 2zm9A-2zm2A:99.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3afg | SUBTILISIN-LIKESERINE PROTEASE (Thermococcuskodakarensis) |
PF00082(Peptidase_S8)PF04151(PPC) | 4 | MET A 202ALA A 203GLY A 367ILE A 368 | None | 0.81A | 2zm9A-3afgA:undetectable | 2zm9A-3afgA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3all | 2-METHYL-3-HYDROXYPYRIDINE-5-CARBOXYLICACID OXYGENASE (Mesorhizobiumjaponicum) |
PF01494(FAD_binding_3) | 4 | ALA A 17HIS A 40GLY A 154ILE A 152 | FAD A 380 ( 4.5A)NoneNoneNone | 0.76A | 2zm9A-3allA:undetectable | 2zm9A-3allA:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bbl | REGULATORY PROTEINOF LACI FAMILY (Chloroflexusaggregans) |
PF13377(Peripla_BP_3) | 4 | MET A 263ALA A 264GLY A 261ILE A 260 | EDO A 503 (-4.5A)EDO A 503 (-3.7A)NoneNone | 0.58A | 2zm9A-3bblA:undetectable | 2zm9A-3bblA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bg2 | DGTPTRIPHOSPHOHYDROLASE (Leeuwenhoekiellablandensis) |
PF01966(HD) | 4 | ALA A 371TYR A 435GLY A 372ILE A 375 | None | 0.92A | 2zm9A-3bg2A:undetectable | 2zm9A-3bg2A:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bxp | PUTATIVELIPASE/ESTERASE (Lactobacillusplantarum) |
PF07859(Abhydrolase_3) | 4 | ALA A 117TYR A 72HIS A 120GLY A 44 | None | 0.73A | 2zm9A-3bxpA:undetectable | 2zm9A-3bxpA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cpi | RAB GDP-DISSOCIATIONINHIBITOR (Saccharomycescerevisiae) |
PF00996(GDI) | 4 | MET G 197ALA G 198GLY G 194ILE G 193 | None | 0.61A | 2zm9A-3cpiG:undetectable | 2zm9A-3cpiG:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dmb | PUTATIVE GENERALSTRESS PROTEIN 26WITH A PNP-OXIDASELIKE FOLD (Xanthomonascampestris) |
PF16242(Pyrid_ox_like) | 4 | ALA A 71TRP A 130GLY A 70ILE A 69 | None | 0.86A | 2zm9A-3dmbA:undetectable | 2zm9A-3dmbA:17.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e77 | PHOSPHOSERINEAMINOTRANSFERASE (Homo sapiens) |
PF00266(Aminotran_5) | 4 | MET A 267ALA A 264GLY A 263ILE A 258 | None | 0.82A | 2zm9A-3e77A:undetectable | 2zm9A-3e77A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fbs | OXIDOREDUCTASE (Agrobacteriumfabrum) |
PF07992(Pyr_redox_2) | 4 | MET A 108ALA A 107GLY A 9ILE A 8 | NoneNoneFAD A 298 (-3.4A)None | 0.84A | 2zm9A-3fbsA:undetectable | 2zm9A-3fbsA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3flb | RIFR (Amycolatopsismediterranei) |
PF00975(Thioesterase) | 4 | TYR A 180HIS A 214GLY A 100ILE A 98 | None | 0.90A | 2zm9A-3flbA:undetectable | 2zm9A-3flbA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hh8 | METAL ABCTRANSPORTERSUBSTRATE-BINDINGLIPOPROTEIN (Streptococcuspyogenes) |
PF01297(ZnuA) | 4 | MET A 295ALA A 294GLY A 289ILE A 282 | None | 0.78A | 2zm9A-3hh8A:undetectable | 2zm9A-3hh8A:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hut | PUTATIVEBRANCHED-CHAIN AMINOACID ABC TRANSPORTER (Rhodospirillumrubrum) |
PF13458(Peripla_BP_6) | 4 | MET A 238ALA A 237GLY A 182ILE A 181 | None | 0.90A | 2zm9A-3hutA:undetectable | 2zm9A-3hutA:25.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ib5 | SEX PHEROMONEPRECURSOR (Lactobacillussalivarius) |
PF07537(CamS) | 5 | MET A 227ALA A 226TRP A 256GLY A 171ILE A 172 | None | 1.49A | 2zm9A-3ib5A:undetectable | 2zm9A-3ib5A:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ism | CG8862 (Drosophilamelanogaster) |
PF01223(Endonuclease_NS) | 4 | MET A 77TRP A 106GLY A 74ILE A 73 | None | 0.89A | 2zm9A-3ismA:undetectable | 2zm9A-3ismA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m49 | TRANSKETOLASE (Bacillusanthracis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | MET A 334ALA A 333TYR A 139GLY A 427 | None | 0.79A | 2zm9A-3m49A:undetectable | 2zm9A-3m49A:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nxl | GLUCARATEDEHYDRATASE (Burkholderialata) |
PF13378(MR_MLE_C) | 4 | TYR A 184HIS A 36GLY A 175ILE A 174 | NoneCO3 A 477 (-4.0A)NoneNone | 0.82A | 2zm9A-3nxlA:undetectable | 2zm9A-3nxlA:24.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qbt | INOSITOLPOLYPHOSPHATE5-PHOSPHATASE OCRL-1RAS-RELATED PROTEINRAB-8A (Homo sapiens) |
PF00071(Ras)no annotation | 4 | TYR A 77HIS B 660GLY A 42ILE A 43 | NoneNoneSO4 B 1 ( 4.2A)None | 0.65A | 2zm9A-3qbtA:undetectable | 2zm9A-3qbtA:17.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qe7 | URACIL PERMEASE (Escherichiacoli) |
PF00860(Xan_ur_permease) | 4 | MET A 295ALA A 296GLY A 293ILE A 292 | None | 0.68A | 2zm9A-3qe7A:undetectable | 2zm9A-3qe7A:24.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qlv | GLUTAMATE RECEPTOR,IONOTROPIC KAINATE 5 (Rattusnorvegicus) |
PF01094(ANF_receptor) | 4 | MET A 380ALA A 379GLY A 370ILE A 369 | None | 0.59A | 2zm9A-3qlvA:undetectable | 2zm9A-3qlvA:23.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rp7 | FLAVOPROTEINMONOOXYGENASE (Klebsiellapneumoniae) |
PF01494(FAD_binding_3) | 4 | MET A 302ALA A 301GLY A 11ILE A 10 | NoneFAD A 385 ( 4.5A)FAD A 385 (-3.5A)FAD A 385 (-4.1A) | 0.89A | 2zm9A-3rp7A:undetectable | 2zm9A-3rp7A:24.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t33 | G PROTEIN COUPLEDRECEPTOR (Arabidopsisthaliana) |
PF05147(LANC_like) | 4 | MET A 390ALA A 391GLY A 388ILE A 387 | None | 0.72A | 2zm9A-3t33A:undetectable | 2zm9A-3t33A:23.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u0n | MRUBY (Entacmaeaquadricolor) |
PF01353(GFP) | 4 | ALA A 222TYR A 148GLY A 226ILE A 192 | None | 0.92A | 2zm9A-3u0nA:undetectable | 2zm9A-3u0nA:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u34 | GENERAL STRESSPROTEIN (Xanthomonascitri) |
PF16242(Pyrid_ox_like) | 4 | ALA A 91TRP A 150GLY A 90ILE A 89 | PGE A 183 (-4.3A)NoneNoneNone | 0.90A | 2zm9A-3u34A:undetectable | 2zm9A-3u34A:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vco | DIHYDROFOLATEREDUCTASE (Schistosomamansoni) |
PF00186(DHFR_1) | 4 | ALA A 8TYR A 117GLY A 16ILE A 15 | None | 0.91A | 2zm9A-3vcoA:undetectable | 2zm9A-3vcoA:18.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zq6 | PUTATIVE ARSENICALPUMP-DRIVING ATPASE (Methanothermobacterthermautotrophicus) |
PF02374(ArsA_ATPase) | 4 | MET A 179ALA A 180GLY A 177ILE A 176 | None | 0.66A | 2zm9A-3zq6A:undetectable | 2zm9A-3zq6A:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bfr | PHOSPHATIDYLINOSITOL4,5-BISPHOSPHATE3-KINASE CATALYTIC SSUBUNIT BETA ISOFORM (Mus musculus) |
PF00454(PI3_PI4_kinase)PF00613(PI3Ka)PF00792(PI3K_C2)PF00794(PI3K_rbd) | 4 | ALA A 735TYR A 772HIS A 737ILE A 720 | None | 0.88A | 2zm9A-4bfrA:undetectable | 2zm9A-4bfrA:17.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c90 | ALPHA-GLUCURONIDASEGH115 (Bacteroidesovatus) |
PF15979(Glyco_hydro_115) | 4 | MET A 279ALA A 280GLY A 312ILE A 313 | None | 0.58A | 2zm9A-4c90A:undetectable | 2zm9A-4c90A:17.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g8t | GLUCARATEDEHYDRATASE (Actinobacillussuccinogenes) |
PF13378(MR_MLE_C) | 4 | TYR A 160HIS A 28GLY A 151ILE A 150 | NoneSO4 A 501 (-4.2A)NoneNone | 0.84A | 2zm9A-4g8tA:undetectable | 2zm9A-4g8tA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g9k | ROTENONE-INSENSITIVENADH-UBIQUINONEOXIDOREDUCTASE (Saccharomycescerevisiae) |
PF07992(Pyr_redox_2) | 4 | ALA A 396HIS A 397GLY A 382ILE A 381 | ALA A 396 (-0.0A)HIS A 397 ( 1.0A)GLY A 382 (-0.0A)ILE A 381 ( 0.7A) | 0.79A | 2zm9A-4g9kA:undetectable | 2zm9A-4g9kA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gm6 | PFKB FAMILYCARBOHYDRATE KINASE (Listeria grayi) |
PF00294(PfkB) | 4 | MET A 64ALA A 65GLY A 62ILE A 61 | None | 0.73A | 2zm9A-4gm6A:undetectable | 2zm9A-4gm6A:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gyp | GLUCARATEDEHYDRATASE-RELATEDPROTEIN (Escherichiacoli) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | TYR C 163HIS C 31GLY C 154ILE C 153 | NoneCIT C 501 (-3.9A)NoneNone | 0.87A | 2zm9A-4gypC:undetectable | 2zm9A-4gypC:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hea | NADH-QUINONEOXIDOREDUCTASESUBUNIT 12 (Thermusthermophilus) |
PF00361(Proton_antipo_M)PF00662(Proton_antipo_N) | 4 | ALA L 213TYR L 260GLY L 249ILE L 253 | None | 0.86A | 2zm9A-4heaL:undetectable | 2zm9A-4heaL:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hn8 | D-GLUCARATEDEHYDRATASE (Pseudomonasmendocina) |
PF13378(MR_MLE_C) | 4 | TYR A 181HIS A 34GLY A 172ILE A 171 | NoneGOL A 502 (-4.3A)NoneNone | 0.81A | 2zm9A-4hn8A:undetectable | 2zm9A-4hn8A:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hyn | CHEC, INHIBITOR OFMCP METHYLATION /FLIN FUSION PROTEIN (Thermotogamaritima) |
PF04509(CheC) | 5 | MET A 138ALA A 141TYR A 86GLY A 139ILE A 155 | None | 1.35A | 2zm9A-4hynA:undetectable | 2zm9A-4hynA:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4igo | OS05G0196500 PROTEIN (Oryza sativa) |
PF02373(JmjC)PF02375(JmjN) | 4 | ALA A 480TRP A 393GLY A 182ILE A 183 | None | 0.67A | 2zm9A-4igoA:undetectable | 2zm9A-4igoA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4il5 | CYSTEINE SYNTHASE (Entamoebahistolytica) |
PF00291(PALP) | 4 | MET A 265ALA A 266GLY A 282ILE A 285 | None | 0.66A | 2zm9A-4il5A:undetectable | 2zm9A-4il5A:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o87 | N-TAGGED NUCLEASE (Millerozymaacaciae) |
no annotation | 4 | MET A 15ALA A 16GLY A 13ILE A 12 | None | 0.62A | 2zm9A-4o87A:undetectable | 2zm9A-4o87A:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oa7 | TANKYRASE-1 (Homo sapiens) |
PF00644(PARP) | 4 | ALA A1138TYR A1224HIS A1132GLY A1230 | None2XS A1402 ( 3.9A)NoneNone | 0.85A | 2zm9A-4oa7A:undetectable | 2zm9A-4oa7A:18.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ovt | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Ochrobactrumanthropi) |
PF03480(DctP) | 4 | MET A 80ALA A 79GLY A 241ILE A 137 | None | 0.79A | 2zm9A-4ovtA:undetectable | 2zm9A-4ovtA:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q3k | MGS-M1 (unidentified) |
PF00326(Peptidase_S9)PF07859(Abhydrolase_3) | 4 | ALA A 114TYR A 71HIS A 117GLY A 43 | F A 302 (-3.6A)NoneNone F A 302 (-3.4A) | 0.88A | 2zm9A-4q3kA:undetectable | 2zm9A-4q3kA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qt4 | PEPTIDYL-TRNAHYDROLASE (Streptococcuspyogenes) |
PF01195(Pept_tRNA_hydro) | 4 | MET A 25ALA A 26GLY A 23ILE A 22 | None | 0.63A | 2zm9A-4qt4A:undetectable | 2zm9A-4qt4A:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4udn | PERIPLASMIC SOLUTEBINDING PROTEIN (CandidatusLiberibacterasiaticus) |
PF01297(ZnuA) | 5 | MET A 115ALA A 114TYR A 143TYR A 259ILE A 118 | None | 1.12A | 2zm9A-4udnA:undetectable | 2zm9A-4udnA:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v0p | MELANOMA-ASSOCIATEDANTIGEN 3 (Homo sapiens) |
PF01454(MAGE) | 4 | ALA A 199TYR A 124GLY A 163ILE A 164 | None | 0.87A | 2zm9A-4v0pA:undetectable | 2zm9A-4v0pA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wpc | RHOGTPASE-ACTIVATINGPROTEIN RGD1 (Saccharomycescerevisiae) |
no annotation | 4 | MET A 112ALA A 113HIS A 76GLY A 110 | None | 0.90A | 2zm9A-4wpcA:undetectable | 2zm9A-4wpcA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z3n | PUTATIVE DRUG/SODIUMANTIPORTER (Escherichiacoli) |
PF01554(MatE) | 4 | MET A 289ALA A 288TYR A 277TYR A 436 | NoneNoneOLC A 501 (-3.6A)None | 0.80A | 2zm9A-4z3nA:undetectable | 2zm9A-4z3nA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z7r | COENZYME PQQSYNTHESIS PROTEIN B (Methylobacteriumextorquens) |
PF12706(Lactamase_B_2) | 4 | ALA A 197HIS A 240GLY A 172ILE A 171 | None | 0.83A | 2zm9A-4z7rA:undetectable | 2zm9A-4z7rA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a9a | POLYHEDRIN (Simuliumubiquitumcypovirus) |
PF17515(CPV_Polyhedrin) | 4 | TYR A 225TYR A 47GLY A 212ILE A 215 | None | 0.90A | 2zm9A-5a9aA:undetectable | 2zm9A-5a9aA:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ams | RIBOSOME ASSEMBLYPROTEIN SQT1 (Saccharomycescerevisiae) |
no annotation | 4 | ALA A 148HIS A 136GLY A 189ILE A 184 | None | 0.91A | 2zm9A-5amsA:undetectable | 2zm9A-5amsA:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d7w | SERRALYSIN (Serratiamarcescens) |
PF00353(HemolysinCabind)PF00413(Peptidase_M10)PF08548(Peptidase_M10_C) | 4 | ALA A 240TRP A 96GLY A 36ILE A 39 | ALA A 240 ( 0.0A)TRP A 96 ( 0.5A)GLY A 36 ( 0.0A)ILE A 39 ( 0.7A) | 0.90A | 2zm9A-5d7wA:undetectable | 2zm9A-5d7wA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fwj | HISTONE DEMETHYLASEJARID1C (Homo sapiens) |
PF02373(JmjC)PF02375(JmjN)PF02928(zf-C5HC2) | 4 | ALA A 600TRP A 513GLY A 42ILE A 43 | None | 0.68A | 2zm9A-5fwjA:undetectable | 2zm9A-5fwjA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ip9 | DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB1 (Saccharomycescerevisiae) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04990(RNA_pol_Rpb1_7)PF04992(RNA_pol_Rpb1_6)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 4 | ALA A1440HIS A 851GLY A1439ILE A1436 | None | 0.71A | 2zm9A-5ip9A:undetectable | 2zm9A-5ip9A:12.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iqk | BETA-LACTAMASE RM3 (unculturedbacterium) |
PF00753(Lactamase_B) | 4 | ALA A 114HIS A 108GLY A 115ILE A 111 | None ZN A 401 (-3.2A)NoneNone | 0.89A | 2zm9A-5iqkA:undetectable | 2zm9A-5iqkA:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kia | L-THREONINE3-DEHYDROGENASE (Burkholderiathailandensis) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | MET A 178ALA A 179GLY A 176ILE A 175 | None | 0.69A | 2zm9A-5kiaA:undetectable | 2zm9A-5kiaA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kp7 | CURD (Mooreaproducens) |
PF01154(HMG_CoA_synt_N)PF08540(HMG_CoA_synt_C) | 4 | ALA A 43TYR A 54GLY A 169ILE A 297 | None | 0.77A | 2zm9A-5kp7A:undetectable | 2zm9A-5kp7A:23.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kva | CAFFEOYL-COAO-METHYLTRANSFERASE (Sorghum bicolor) |
PF01596(Methyltransf_3) | 4 | MET A 124TYR A 186GLY A 101ILE A 100 | NoneNoneSAM A 301 (-3.4A)None | 0.73A | 2zm9A-5kvaA:undetectable | 2zm9A-5kvaA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l94 | CYTOCHROME P450 (Bacillusmegaterium) |
PF00067(p450) | 4 | ALA A 79TYR A 199GLY A 234ILE A 237 | None | 0.79A | 2zm9A-5l94A:undetectable | 2zm9A-5l94A:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ld5 | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Atopobiumvaginae) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 4 | ALA A 129HIS A 98GLY A 130ILE A 127 | None | 0.92A | 2zm9A-5ld5A:undetectable | 2zm9A-5ld5A:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mr6 | XIAF PROTEIN (Streptomycessp.) |
PF08028(Acyl-CoA_dh_2) | 4 | MET A 240ALA A 241HIS A 371ILE A 237 | GOL A 602 (-3.7A)NoneFAD A 601 (-3.8A)GOL A 602 ( 4.2A) | 0.77A | 2zm9A-5mr6A:undetectable | 2zm9A-5mr6A:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mrv | CARBOXYPEPTIDASE O (Homo sapiens) |
no annotation | 4 | ALA A 197TRP A 82GLY A 57ILE A 65 | None | 0.81A | 2zm9A-5mrvA:undetectable | 2zm9A-5mrvA:11.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ol0 | PUTATIVE SILENTINFORMATIONREGULATOR 2,PUTATIVESILENT INFORMATIONREGULATOR 2 (Leishmaniainfantum) |
no annotation | 4 | ALA A 46HIS A 106GLY A 47ILE A 48 | None | 0.84A | 2zm9A-5ol0A:undetectable | 2zm9A-5ol0A:12.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5svc | ACETONE CARBOXYLASEALPHA SUBUNIT (Xanthobacterautotrophicus) |
PF02538(Hydantoinase_B) | 4 | ALA A 97TYR A 265GLY A 168ILE A 167 | None | 0.91A | 2zm9A-5svcA:undetectable | 2zm9A-5svcA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uth | THIOREDOXINREDUCTASE (Mycolicibacteriumsmegmatis) |
PF07992(Pyr_redox_2) | 4 | MET A 114ALA A 113GLY A 14ILE A 13 | NoneNoneFAD A 400 (-3.1A)FAD A 400 (-4.7A) | 0.86A | 2zm9A-5uthA:undetectable | 2zm9A-5uthA:25.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uti | QUEUINETRNA-RIBOSYLTRANSFERASE (Zymomonasmobilis) |
no annotation | 4 | MET A 346ALA A 343GLY A 342ILE A 335 | None | 0.91A | 2zm9A-5utiA:undetectable | 2zm9A-5utiA:12.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uyg | PERIPLASMIC CHELATEDIRON-BINDING PROTEINYFEA (Yersinia pestis) |
PF01297(ZnuA) | 4 | ALA A 149TYR A 178TYR A 294ILE A 153 | None | 0.91A | 2zm9A-5uygA:undetectable | 2zm9A-5uygA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v44 | SACSIN (Homo sapiens) |
no annotation | 4 | TYR A 157TYR A 138GLY A 252ILE A 253 | NoneNoneNoneGOL A 403 (-4.6A) | 0.88A | 2zm9A-5v44A:undetectable | 2zm9A-5v44A:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v9p | LYSINE-SPECIFICDEMETHYLASE 5A (Homo sapiens) |
PF00628(PHD)PF01388(ARID)PF02373(JmjC)PF02375(JmjN)PF02928(zf-C5HC2)PF08429(PLU-1) | 4 | ALA A 569TRP A 482GLY A 47ILE A 48 | None | 0.62A | 2zm9A-5v9pA:undetectable | 2zm9A-5v9pA:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ykn | PROBABLELYSINE-SPECIFICDEMETHYLASE JMJ14 (Arabidopsisthaliana) |
no annotation | 4 | ALA A 395TRP A 308GLY A 84ILE A 85 | None | 0.66A | 2zm9A-5yknA:undetectable | 2zm9A-5yknA:10.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bgz | LYSINE-SPECIFICDEMETHYLASE 5A,LINKED KDM5A JMJDOMAIN (Homo sapiens) |
no annotation | 4 | ALA A 569TRP A 482GLY A 47ILE A 48 | None | 0.65A | 2zm9A-6bgzA:undetectable | 2zm9A-6bgzA:12.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c26 | DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEINGLYCOSYLTRANSFERASESUBUNIT STT3 (Saccharomycescerevisiae) |
no annotation | 5 | MET A 267ALA A 269TYR A 243HIS A 266GLY A 271 | EGY A 803 (-4.6A)NoneNoneNoneEGY A 803 ( 4.4A) | 1.39A | 2zm9A-6c26A:undetectable | 2zm9A-6c26A:11.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ek6 | LYSINE-SPECIFICDEMETHYLASE5B,LYSINE-SPECIFICDEMETHYLASE 5B (Homo sapiens) |
no annotation | 4 | ALA A 585TRP A 498GLY A 60ILE A 61 | None | 0.65A | 2zm9A-6ek6A:undetectable | 2zm9A-6ek6A:12.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6epi | ZETA_1 TOXIN (Neisseriagonorrhoeae) |
no annotation | 4 | MET B 188ALA B 189GLY B 186ILE B 185 | NoneNoneSO4 B 503 ( 4.4A)None | 0.77A | 2zm9A-6epiB:undetectable | 2zm9A-6epiB:11.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gbc | MOLYBDOPTERINBIOSYNTHESIS PROTEINCNX1 (Arabidopsisthaliana) |
no annotation | 4 | ALA A 178TYR A 41GLY A 175ILE A 174 | None | 0.81A | 2zm9A-6gbcA:undetectable | 2zm9A-6gbcA:undetectable |