SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZM9_A_ACAA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)

(Allochromatium
vinosum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		5 ALA A  77
ILE A  80
GLY A  79
ILE A 264
HIS A 286
 FAD  A 699 (-3.2A)
None
None
None
None
 1.45A 2zm9A-1fcdA:
0.0		 2zm9A-1fcdA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Borreliella
burgdorferi) 		PF02127
(Peptidase_M18) 		5 ALA A 251
TYR A  25
ILE A 439
GLY A 250
ILE A 249
 None
 1.28A 2zm9A-1y7eA:
0.0		 2zm9A-1y7eA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avn UBIQUINONE/MENAQUINO
NE BIOSYNTHESIS
METHYLTRANSFERASE-RE
LATED PROTEIN

(Thermotoga
maritima) 		PF08241
(Methyltransf_11) 		5 ALA A 235
TRP A 233
ILE A 232
GLY A 200
ILE A 201
 None
 1.19A 2zm9A-2avnA:
0.0		 2zm9A-2avnA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avn UBIQUINONE/MENAQUINO
NE BIOSYNTHESIS
METHYLTRANSFERASE-RE
LATED PROTEIN

(Thermotoga
maritima) 		PF08241
(Methyltransf_11) 		5 ALA A 235
TYR A  28
ILE A 238
GLY A 200
ILE A 201
 None
 1.44A 2zm9A-2avnA:
0.0		 2zm9A-2avnA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glf PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Thermotoga
maritima) 		PF02127
(Peptidase_M18) 		5 ALA A 247
TYR A  25
ILE A 432
GLY A 246
ILE A 245
 None
 1.19A 2zm9A-2glfA:
0.0		 2zm9A-2glfA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n4x CYTOCHROME C-TYPE
BIOGENESIS PROTEIN
(CCDA)

(Archaeoglobus
fulgidus) 		no annotation 5 ALA A 123
TYR A 142
ILE A 125
GLY A 124
ILE A 127
 None
 1.10A 2zm9A-2n4xA:
0.0		 2zm9A-2n4xA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgi PYRUVATE KINASE
ISOZYMES R/L

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		5 ALA A 346
TYR A 218
ILE A 344
GLY A 341
ILE A 342
 None
 1.06A 2zm9A-2vgiA:
0.0		 2zm9A-2vgiA:
22.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zm2 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Flavobacterium
sp.) 		PF00144
(Beta-lactamase) 		5 TYR A 215
TRP A 331
ILE A 343
GLY A 344
ILE A 345
 GOL  A 505 ( 4.4A)
MES  A 501 (-4.0A)
MES  A 501 (-4.2A)
MES  A 501 (-3.5A)
MES  A 504 ( 3.7A)
 0.18A 2zm9A-2zm2A:
68.2		 2zm9A-2zm2A:
99.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihm STYRENE
MONOOXYGENASE A

(Pseudomonas
putida) 		no annotation 5 ALA A  10
TYR A  39
GLY A  11
TYR A 101
HIS A  50
 None
 1.42A 2zm9A-3ihmA:
0.0		 2zm9A-3ihmA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvg CLATHRIN HEAVY CHAIN
1

(Bos taurus) 		PF00637
(Clathrin) 		5 ALA A1269
TYR A1290
ILE A1276
GLY A1273
HIS A1279
 None
 1.37A 2zm9A-3lvgA:
0.0		 2zm9A-3lvgA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2n 3,6-ANHYDRO-ALPHA-L-
GALACTOSIDASE

(Zobellia
galactanivorans) 		PF04616
(Glyco_hydro_43) 		5 ALA A 337
ILE A 341
GLY A 340
ILE A 320
TYR A 263
 None
 1.48A 2zm9A-3p2nA:
undetectable		 2zm9A-3p2nA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qq3 MHC CLASS I ANTIGEN

(Sus scrofa) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 TYR A 123
TYR A  84
GLY A  77
TYR A 118
HIS A  93
 None
 0.99A 2zm9A-3qq3A:
undetectable		 2zm9A-3qq3A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tav METHIONINE
AMINOPEPTIDASE

(Mycobacteroides
abscessus) 		PF00557
(Peptidase_M24) 		5 ALA A 146
ILE A 144
GLY A 143
ILE A 160
HIS A 249
 None
 1.42A 2zm9A-3tavA:
undetectable		 2zm9A-3tavA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4j NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 ALA A 365
ILE A 361
GLY A 360
ILE A 396
HIS A 354
 None
 0.92A 2zm9A-3u4jA:
undetectable		 2zm9A-3u4jA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162

(Thermotoga
maritima) 		PF12706
(Lactamase_B_2) 		5 ALA A 199
ILE A 197
GLY A 164
ILE A 163
HIS A   8
 None
 1.25A 2zm9A-3x2zA:
undetectable		 2zm9A-3x2zA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu8 GLYCOSIDE HYDROLASE
2

(Streptococcus
pneumoniae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 ALA A 280
GLY A 294
ILE A 295
TYR A 296
HIS A 451
 None
 1.25A 2zm9A-4cu8A:
undetectable		 2zm9A-4cu8A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Dickeya
paradisiaca) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 323
TYR A 125
TYR A 247
GLY A 349
TYR A 150
 None
 1.41A 2zm9A-4ihcA:
undetectable		 2zm9A-4ihcA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zut CLASSICAL MHC CLASS
I ANTIGEN

(Equus caballus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 TYR A 123
TYR A  84
GLY A  77
TYR A 118
HIS A  93
 None
 0.98A 2zm9A-4zutA:
undetectable		 2zm9A-4zutA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es6 LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00551
(Formyl_trans_N) 		5 TYR A 378
TYR A 478
GLY A 380
TYR A 375
HIS A 405
 None
 1.44A 2zm9A-5es6A:
undetectable		 2zm9A-5es6A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00551
(Formyl_trans_N)
PF13193
(AMP-binding_C) 		5 TYR A 378
TYR A 478
GLY A 380
TYR A 375
HIS A 405
 None
 1.45A 2zm9A-5es9A:
undetectable		 2zm9A-5es9A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbe INACTIVE
GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF02324
(Glyco_hydro_70) 		5 TYR A1513
ILE A1581
GLY A1582
ILE A1583
TYR A1518
 None
 1.18A 2zm9A-5jbeA:
undetectable		 2zm9A-5jbeA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfq GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Geoglobus
acetivorans) 		PF00348
(polyprenyl_synt) 		5 ALA A 181
ILE A 177
GLY A 178
ILE A 179
HIS A  74
 None
 1.34A 2zm9A-5jfqA:
undetectable		 2zm9A-5jfqA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		no annotation 5 TYR C 378
TYR C 478
GLY C 380
TYR C 375
HIS C 405
 None
 1.46A 2zm9A-5jnfC:
undetectable		 2zm9A-5jnfC:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy9 PUTATIVE SALICYLATE
SYNTHETASE

(Yersinia
enterocolitica) 		PF00425
(Chorismate_bind) 		5 ALA A 406
TYR A 175
ILE A 408
GLY A 407
ILE A 195
 None
None
None
ACT  A 503 (-3.8A)
ACT  A 502 ( 4.8A)
 1.28A 2zm9A-5jy9A:
undetectable		 2zm9A-5jy9A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysx -

(-) 		no annotation 5 ALA A 136
GLY A 155
ILE A 154
TYR A  80
HIS A  72
 None
 1.20A 2zm9A-5ysxA:
undetectable		 2zm9A-5ysxA:
undetectable