SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZM8_A_ACAA511_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bii MHC CLASS I H-2DD

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.95A 2zm8A-1biiA:
0.0		 2zm8A-1biiA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cwu ENOYL ACP REDUCTASE

(Brassica napus) 		PF13561
(adh_short_C2) 		4 ALA A 233
TYR A  32
ILE A 231
HIS A 135
 NAD  A 501 (-3.6A)
None
None
None
 1.00A 2zm8A-1cwuA:
0.0		 2zm8A-1cwuA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ed3 CLASS I MAJOR
HISTOCOMPATIBILITY
ANTIGEN RT1-AA

(Rattus
norvegicus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 1.01A 2zm8A-1ed3A:
0.0		 2zm8A-1ed3A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eys PHOTOSYNTHETIC
REACTION CENTER

(Thermochromatium
tepidum) 		PF00124
(Photo_RC) 		4 ALA L 101
TYR L 156
ILE L  99
ILE L  97
 BPH  L 606 ( 3.9A)
BPH  L 606 (-3.7A)
None
None
 0.95A 2zm8A-1eysL:
undetectable		 2zm8A-1eysL:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3j BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00303
(Thymidylat_synt) 		4 ALA C 486
ILE C 429
TYR C 430
HIS C 491
 None
None
None
UMP  C 611 (-4.2A)
 0.92A 2zm8A-1j3jC:
0.0		 2zm8A-1j3jC:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 ALA A 157
ILE A 159
ILE A 319
HIS A 322
 None
 0.88A 2zm8A-1jhzA:
undetectable		 2zm8A-1jhzA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8d QA-2 ANTIGEN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.89A 2zm8A-1k8dA:
0.0		 2zm8A-1k8dA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kjv MATURE ALPHA CHAIN
OF MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
ANTIGEN (HEAVY
CHAIN)

(Rattus
norvegicus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.95A 2zm8A-1kjvA:
0.0		 2zm8A-1kjvA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ld9 MHC CLASS I H-2LD
HEAVY CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.91A 2zm8A-1ld9A:
0.0		 2zm8A-1ld9A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhw ENOYL-ACYL CARRIER
REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		4 ALA A 312
TYR A 111
ILE A 310
HIS A 214
 NAD  A 450 (-3.7A)
NAD  A 450 (-4.6A)
None
None
 0.93A 2zm8A-1nhwA:
undetectable		 2zm8A-1nhwA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkq HYPOTHETICAL 28.8
KDA PROTEIN IN
PSD1-SKO1 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF01557
(FAA_hydrolase) 		4 ALA A  91
TYR A   5
ILE A 212
ILE A  93
 None
 1.00A 2zm8A-1nkqA:
undetectable		 2zm8A-1nkqA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus) 		PF00067
(p450) 		4 ALA A 468
ILE A 466
ILE A 356
HIS A 313
 None
 1.02A 2zm8A-1nr6A:
undetectable		 2zm8A-1nr6A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh3 NON-CATALYTIC
PROTEIN 1

(Piromyces equi) 		no annotation 4 ALA A  36
TYR A  97
ILE A 127
ILE A  38
 None
 0.97A 2zm8A-1oh3A:
undetectable		 2zm8A-1oh3A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1onk GALACTOSE SPECIFIC
LECTIN I B CHAIN

(Viscum album) 		PF00652
(Ricin_B_lectin) 		4 ALA B 233
TRP B 259
ILE B 225
ILE B 248
 None
 1.03A 2zm8A-1onkB:
undetectable		 2zm8A-1onkB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7s H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, K-B ALPHA
CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.97A 2zm8A-1s7sA:
undetectable		 2zm8A-1s7sA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7u H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, D-B ALPHA
CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.94A 2zm8A-1s7uA:
undetectable		 2zm8A-1s7uA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmc CLASS I
HISTOCOMPATIBILITY
ANTIGEN (HLA-AW68)

(Homo sapiens) 		PF00129
(MHC_I) 		4 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.95A 2zm8A-1tmcA:
undetectable		 2zm8A-1tmcA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvp CELLULASE

(Pseudoalteromonas
haloplanktis) 		PF00150
(Cellulase) 		4 ALA A  14
TYR A  94
ILE A  12
HIS A 253
 None
 0.84A 2zm8A-1tvpA:
undetectable		 2zm8A-1tvpA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twl INORGANIC
PYROPHOSPHATASE

(Pyrococcus
furiosus) 		PF00719
(Pyrophosphatase) 		4 ALA A 166
TRP A  63
ILE A  59
HIS A   5
 None
 1.03A 2zm8A-1twlA:
undetectable		 2zm8A-1twlA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YIAJ

(Escherichia
coli) 		PF01614
(IclR) 		4 TYR A 144
ILE A  11
ILE A   9
HIS A  15
 None
 0.98A 2zm8A-1ysqA:
undetectable		 2zm8A-1ysqA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anc GUANYLATE KINASE

(Escherichia
coli) 		PF00625
(Guanylate_kin) 		4 ALA A 185
TYR A 165
ILE A 182
TYR A   7
 None
 0.97A 2zm8A-2ancA:
undetectable		 2zm8A-2ancA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2auj DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN

(Thermus
aquaticus) 		no annotation 5 ALA D 379
TYR D 345
TYR D 215
ILE D 367
HIS D 386
 None
 1.45A 2zm8A-2aujD:
undetectable		 2zm8A-2aujD:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpq ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 ALA A  66
TYR A 186
ILE A 196
ILE A  62
 None
 0.95A 2zm8A-2bpqA:
undetectable		 2zm8A-2bpqA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cmh SPERMIDINE SYNTHASE

(Helicobacter
pylori) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 ALA A 245
TYR A 236
ILE A 241
TYR A 237
 None
 0.82A 2zm8A-2cmhA:
undetectable		 2zm8A-2cmhA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2foi ENOYL-ACYL CARRIER
REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		4 ALA A 312
TYR A 111
ILE A 310
HIS A 214
 NAD  A 450 (-3.8A)
NAD  A 450 (-4.7A)
None
None
 0.97A 2zm8A-2foiA:
undetectable		 2zm8A-2foiA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gou OXIDOREDUCTASE,
FMN-BINDING

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		4 ALA A 316
TYR A 302
ILE A 297
ILE A 319
 None
 0.92A 2zm8A-2gouA:
undetectable		 2zm8A-2gouA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Thermus
thermophilus) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 ALA A 219
TYR A 399
ILE A 216
ILE A 214
 None
 0.90A 2zm8A-2ipcA:
undetectable		 2zm8A-2ipcA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00977
(His_biosynth) 		4 ALA A  54
TYR A  21
ILE A  28
ILE A  56
 None
 0.99A 2zm8A-2lleA:
undetectable		 2zm8A-2lleA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ol3 ALLOGENEIC H-2KBM8
MHC CLASS I MOLECULE

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR H 123
TYR H  84
TYR H 118
HIS H  93
 None
 0.92A 2zm8A-2ol3H:
undetectable		 2zm8A-2ol3H:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owp HYPOTHETICAL PROTEIN
BXE_B1374

(Paraburkholderia
xenovorans) 		PF11533
(DUF3225) 		4 ALA A 120
TYR A  19
ILE A 117
HIS A  37
 None
None
None
EDO  A 137 ( 4.0A)
 0.80A 2zm8A-2owpA:
undetectable		 2zm8A-2owpA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 337
ILE A 339
ILE A 305
HIS A 312
 None
 0.73A 2zm8A-2pceA:
undetectable		 2zm8A-2pceA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qri H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN K-B ALPHA
CHAIN, BETA-2
MICROGLOBULIN,
OVALBUMIN-DERIVED
PEPTIDE

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 1.01A 2zm8A-2qriA:
undetectable		 2zm8A-2qriA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xcz POSSIBLE ATLS1-LIKE
LIGHT-INDUCIBLE
PROTEIN

(Prochlorococcus
marinus) 		PF01187
(MIF) 		4 ALA A   7
ILE A   5
ILE A  89
HIS A  82
 None
 1.02A 2zm8A-2xczA:
undetectable		 2zm8A-2xczA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoy RBAM17540

(Bacillus
amyloliquefaciens) 		PF03067
(LPMO_10) 		4 ILE A  31
ILE A 183
TYR A 132
HIS A 169
 None
 1.04A 2zm8A-2yoyA:
undetectable		 2zm8A-2yoyA:
18.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zm2 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Flavobacterium
sp.) 		PF00144
(Beta-lactamase) 		4 TYR A 215
TRP A 331
ILE A 343
ILE A 345
 GOL  A 505 ( 4.4A)
MES  A 501 (-4.0A)
MES  A 501 (-4.2A)
MES  A 504 ( 3.7A)
 0.21A 2zm8A-2zm2A:
67.1		 2zm8A-2zm2A:
98.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bze HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, ALPHA CHAIN
E

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.98A 2zm8A-3bzeA:
undetectable		 2zm8A-3bzeA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF00857
(Isochorismatase) 		4 ALA A 107
TYR A  86
ILE A 110
ILE A 104
 None
 1.00A 2zm8A-3eefA:
undetectable		 2zm8A-3eefA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ery H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN

(Homo sapiens) 		PF00129
(MHC_I) 		4 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.97A 2zm8A-3eryA:
undetectable		 2zm8A-3eryA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE

(Plasmodium
berghei) 		PF13561
(adh_short_C2) 		4 ALA A 297
TYR A  94
ILE A 295
HIS A 199
 NAD  A 450 (-3.6A)
None
None
None
 1.03A 2zm8A-3f4bA:
undetectable		 2zm8A-3f4bA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2

(Homo sapiens) 		PF01852
(START) 		4 ALA A 492
ILE A 471
ILE A 490
HIS A 516
 None
 0.91A 2zm8A-3fo5A:
undetectable		 2zm8A-3fo5A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		4 ALA A1390
TYR A1529
ILE A1019
ILE A1403
 None
 0.97A 2zm8A-3hmjA:
undetectable		 2zm8A-3hmjA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hol TBPB

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 ALA A  46
TYR A 258
TYR A 124
ILE A  71
 None
 0.96A 2zm8A-3holA:
undetectable		 2zm8A-3holA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwc CHLOROPHENOL-4-MONOO
XYGENASE COMPONENT 2

(Burkholderia
cepacia) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 ALA A3307
ILE A3303
ILE A3427
TYR A3431
 None
 0.80A 2zm8A-3hwcA:
undetectable		 2zm8A-3hwcA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtn ADAPTER PROTEIN MECA
2

(Bacillus
subtilis) 		PF05389
(MecA) 		4 ALA A  82
ILE A  77
ILE A  13
TYR A  37
 None
None
None
IOD  A  98 (-4.7A)
 1.02A 2zm8A-3jtnA:
undetectable		 2zm8A-3jtnA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8k ALPHA-AMYLASE, SUSG

(Bacteroides
thetaiotaomicron) 		PF00128
(Alpha-amylase) 		4 ALA A 369
TYR A 176
ILE A 370
TYR A 355
 None
EDO  A 903 (-4.9A)
None
None
 1.01A 2zm8A-3k8kA:
undetectable		 2zm8A-3k8kA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyo MHC CLASS I ANTIGEN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.94A 2zm8A-3kyoA:
undetectable		 2zm8A-3kyoA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv0 NTF2-RELATED EXPORT
PROTEIN

(Caenorhabditis
elegans) 		PF02136
(NTF2) 		4 ALA B  48
TYR B  42
TRP B  50
ILE B  61
 None
 0.95A 2zm8A-3nv0B:
undetectable		 2zm8A-3nv0B:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojy COMPLEMENT COMPONENT
C8 BETA CHAIN

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF) 		4 TYR B 250
ILE B 118
TYR B 115
HIS B 149
 None
 0.97A 2zm8A-3ojyB:
undetectable		 2zm8A-3ojyB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE

(Caulobacter
vibrioides) 		PF00348
(polyprenyl_synt) 		4 ALA A 283
TYR A 227
ILE A 255
ILE A 287
 None
 0.92A 2zm8A-3oyrA:
undetectable		 2zm8A-3oyrA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9z UROPORPHYRINOGEN III
COSYNTHASE (HEMD)

(Helicobacter
pylori) 		PF02602
(HEM4) 		4 ALA A 206
ILE A 188
ILE A 186
HIS A   8
 None
 0.89A 2zm8A-3p9zA:
undetectable		 2zm8A-3p9zA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9z UROPORPHYRINOGEN III
COSYNTHASE (HEMD)

(Helicobacter
pylori) 		PF02602
(HEM4) 		4 ALA A 206
ILE A 188
ILE A 186
HIS A 169
 None
 0.79A 2zm8A-3p9zA:
undetectable		 2zm8A-3p9zA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3plr UDP-GLUCOSE
6-DEHYDROGENASE

(Klebsiella
pneumoniae) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 TYR A 210
ILE A 238
ILE A 229
HIS A 241
 None
 1.02A 2zm8A-3plrA:
undetectable		 2zm8A-3plrA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 ALA A 464
ILE A 270
ILE A 462
HIS A 458
 None
FAD  A 690 (-4.6A)
None
None
 0.95A 2zm8A-3pvcA:
undetectable		 2zm8A-3pvcA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwv MHC CLASS I ANTIGEN

(Bos taurus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 122
TYR A  83
TYR A 117
HIS A  92
 None
 0.91A 2zm8A-3pwvA:
undetectable		 2zm8A-3pwvA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qq3 MHC CLASS I ANTIGEN

(Sus scrofa) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.96A 2zm8A-3qq3A:
undetectable		 2zm8A-3qq3A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg9 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
brucei) 		PF00186
(DHFR_1) 		4 ALA A  34
TYR A 166
ILE A  47
ILE A  41
 WRA  A 602 (-3.9A)
None
WRA  A 602 ( 4.5A)
NDP  A 601 (-3.5A)
 1.04A 2zm8A-3rg9A:
undetectable		 2zm8A-3rg9A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rl2 HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, A-3 ALPHA
CHAIN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.98A 2zm8A-3rl2A:
undetectable		 2zm8A-3rl2A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwg MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I

(Macaca mulatta) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 1.04A 2zm8A-3rwgA:
undetectable		 2zm8A-3rwgA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rys ADENOSINE DEAMINASE
1

(Paenarthrobacter
aurescens) 		PF00962
(A_deaminase) 		4 ALA A 141
TYR A 186
ILE A 139
ILE A 168
 None
 1.02A 2zm8A-3rysA:
undetectable		 2zm8A-3rysA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbq NITROUS-OXIDE
REDUCTASE

(Pseudomonas
stutzeri) 		no annotation 4 ALA A 251
TYR A 219
ILE A 280
TYR A 190
 None
 0.99A 2zm8A-3sbqA:
undetectable		 2zm8A-3sbqA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4j NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 ALA A 365
ILE A 361
ILE A 396
HIS A 354
 None
 0.81A 2zm8A-3u4jA:
undetectable		 2zm8A-3u4jA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 ALA A 486
ILE A 429
TYR A 430
HIS A 491
 None
None
None
UMP  A 611 (-3.6A)
 0.94A 2zm8A-3um6A:
undetectable		 2zm8A-3um6A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vns NRPS ADENYLATION
PROTEIN CYTC1

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ALA A 217
TYR A  43
TRP A 215
ILE A 214
 None
 0.97A 2zm8A-3vnsA:
undetectable		 2zm8A-3vnsA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmv SHORT-CHAIN
DEHYDROGENASE

(Sphingobium
yanoikuyae) 		PF00106
(adh_short) 		4 ALA A 194
TRP A 191
ILE A 190
TYR A 153
 None
NAP  A 300 (-4.0A)
NAP  A 300 (-3.7A)
NAP  A 300 (-4.5A)
 0.86A 2zm8A-4bmvA:
undetectable		 2zm8A-4bmvA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyz HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ALA A  95
TYR A 148
ILE A  71
HIS A 233
 None
 1.00A 2zm8A-4cyzA:
undetectable		 2zm8A-4cyzA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER

(Escherichia
coli) 		PF13520
(AA_permease_2) 		4 ALA A 168
TYR A  32
ILE A 164
TYR A  30
 None
 1.01A 2zm8A-4djiA:
undetectable		 2zm8A-4djiA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN

(Rhizobium etli) 		PF01408
(GFO_IDH_MocA) 		4 TYR A 269
ILE A  14
TYR A 265
HIS A 118
 None
 0.92A 2zm8A-4ew6A:
undetectable		 2zm8A-4ew6A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha4 BETA-GALACTOSIDASE

(Acidilobus
saccharovorans) 		PF00232
(Glyco_hydro_1) 		4 TYR A 132
ILE A  81
TYR A  60
HIS A  68
 None
 1.01A 2zm8A-4ha4A:
undetectable		 2zm8A-4ha4A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594

(Pyrococcus
horikoshii) 		PF00326
(Peptidase_S9)
PF07676
(PD40) 		4 ALA B 267
ILE B 269
ILE B 222
HIS B 179
 None
 1.03A 2zm8A-4hxeB:
undetectable		 2zm8A-4hxeB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.95A 2zm8A-4lcyA:
undetectable		 2zm8A-4lcyA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mxn UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF00295
(Glyco_hydro_28) 		4 ALA A 152
ILE A 154
ILE A 178
TYR A 179
 None
 0.86A 2zm8A-4mxnA:
undetectable		 2zm8A-4mxnA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN

(Mus musculus) 		PF00129
(MHC_I) 		4 TYR E 123
TYR E  84
TYR E 118
HIS E  93
 None
 0.88A 2zm8A-4nhuE:
undetectable		 2zm8A-4nhuE:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1m ENOYL-ACYL CARRIER
REDUCTASE

(Toxoplasma
gondii) 		PF13561
(adh_short_C2) 		4 ALA A 224
TYR A  23
ILE A 222
HIS A 126
 NAD  A 401 (-4.0A)
NAD  A 401 (-4.9A)
None
None
 1.02A 2zm8A-4o1mA:
undetectable		 2zm8A-4o1mA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9n ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Chlamydia
trachomatis) 		PF13561
(adh_short_C2) 		4 ALA A 223
TYR A  22
ILE A 221
HIS A 125
 NAI  A 301 (-3.7A)
None
None
None
 0.93A 2zm8A-4q9nA:
undetectable		 2zm8A-4q9nA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udn PERIPLASMIC SOLUTE
BINDING PROTEIN

(Candidatus
Liberibacter
asiaticus) 		PF01297
(ZnuA) 		4 ALA A 114
TYR A 143
TYR A 259
ILE A 118
 None
 0.94A 2zm8A-4udnA:
undetectable		 2zm8A-4udnA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2x NS6 PROTEASE

(Norwalk virus) 		PF05416
(Peptidase_C37) 		4 ALA A 159
ILE A 168
ILE A 109
HIS A 115
 None
 0.93A 2zm8A-4x2xA:
undetectable		 2zm8A-4x2xA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfz MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I

(Macaca mulatta) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.96A 2zm8A-4zfzA:
undetectable		 2zm8A-4zfzA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zut CLASSICAL MHC CLASS
I ANTIGEN

(Equus caballus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 1.00A 2zm8A-4zutA:
undetectable		 2zm8A-4zutA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq1 GLUCOSE-6-PHOSPHATE
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 ALA A 381
ILE A 399
ILE A 302
TYR A 506
 None
 0.90A 2zm8A-5aq1A:
undetectable		 2zm8A-5aq1A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnz GLUTAMINE--TRNA
LIGASE

(Pseudomonas
aeruginosa) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 TYR A 104
ILE A 226
ILE A 223
HIS A 217
 None
 1.04A 2zm8A-5bnzA:
undetectable		 2zm8A-5bnzA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzt CYLM

(Enterococcus
faecalis) 		PF05147
(LANC_like)
PF13575
(DUF4135) 		4 ALA A 355
TYR A 330
ILE A 353
TYR A 333
 None
 1.02A 2zm8A-5dztA:
undetectable		 2zm8A-5dztA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1n MHC CLASS I ANTIGEN

(Canis lupus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.92A 2zm8A-5f1nA:
undetectable		 2zm8A-5f1nA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		PF00520
(Ion_trans)
PF08763
(Ca_chan_IQ)
PF16905
(GPHH) 		4 ALA A 443
ILE A 439
ILE A 538
TYR A 541
 None
 0.96A 2zm8A-5gjvA:
undetectable		 2zm8A-5gjvA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkv ESTERASE A

(Caulobacter
vibrioides) 		PF00144
(Beta-lactamase) 		4 ALA A 356
TYR A 318
TYR A 302
HIS A 328
 None
 1.04A 2zm8A-5gkvA:
26.7		 2zm8A-5gkvA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF09334
(tRNA-synt_1g) 		4 ALA A 291
ILE A 349
TYR A 344
HIS A 340
 None
 0.93A 2zm8A-5gl7A:
undetectable		 2zm8A-5gl7A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsb H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, K-D ALPHA
CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.97A 2zm8A-5gsbA:
undetectable		 2zm8A-5gsbA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE

(Ureibacillus
thermosphaericus) 		PF01113
(DapB_N)
PF16654
(DAPDH_C) 		4 ALA A 117
TYR A 102
ILE A  90
ILE A 119
 None
 0.87A 2zm8A-5gz1A:
undetectable		 2zm8A-5gz1A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxs SODIUM,CALCIUM
EXCHANGER

(Methanocaldococcus
jannaschii) 		PF01699
(Na_Ca_ex) 		4 ALA A  47
TYR A 138
ILE A 238
TYR A 108
 None
 0.99A 2zm8A-5hxsA:
undetectable		 2zm8A-5hxsA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6g H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 1.03A 2zm8A-5j6gA:
undetectable		 2zm8A-5j6gA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd5 MGS-MILE3

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 TYR A 212
ILE A 219
ILE A  29
TYR A 217
 None
 1.00A 2zm8A-5jd5A:
undetectable		 2zm8A-5jd5A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7o DESFERRIOXAMINE
SIDEROPHORE
BIOSYNTHESIS PROTEIN
DFOC

(Erwinia
amylovora) 		no annotation 4 ALA A  95
ILE A  89
TYR A  82
HIS A 103
 None
 1.00A 2zm8A-5o7oA:
undetectable		 2zm8A-5o7oA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA

(Yersinia pestis) 		PF01297
(ZnuA) 		4 ALA A 149
TYR A 178
TYR A 294
ILE A 153
 None
 0.91A 2zm8A-5uygA:
undetectable		 2zm8A-5uygA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 4 ALA A 491
ILE A 947
ILE A 932
TYR A 933
 None
 1.02A 2zm8A-5wlhA:
undetectable		 2zm8A-5wlhA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6

(Homo sapiens) 		PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		4 ALA A 494
TYR B 316
ILE A  72
TYR A  71
 None
 0.95A 2zm8A-5y3rA:
undetectable		 2zm8A-5y3rA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avf HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-7 ALPHA
CHAIN

(Homo sapiens) 		no annotation 4 TYR H 123
TYR H  84
TYR H 118
HIS H  93
 None
 0.94A 2zm8A-6avfH:
undetectable		 2zm8A-6avfH:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bf6 INSULIN-DEGRADING
ENZYME

(Homo sapiens) 		no annotation 4 TYR A 444
ILE A 440
TYR A 443
HIS A  93
 None
 0.98A 2zm8A-6bf6A:
undetectable		 2zm8A-6bf6A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo6 -

(-) 		no annotation 4 ALA A  48
TYR A  68
ILE A 179
HIS A  92
 None
 0.84A 2zm8A-6bo6A:
undetectable		 2zm8A-6bo6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		no annotation 4 ALA A 443
ILE A 439
ILE A 538
TYR A 541
 None
 0.95A 2zm8A-6byoA:
undetectable		 2zm8A-6byoA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 4 ALA A 504
TYR A 517
ILE A 500
TYR A 522
 None
 0.87A 2zm8A-6cgmA:
undetectable		 2zm8A-6cgmA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Acinetobacter
baumannii) 		no annotation 4 ALA A 219
ILE A 217
ILE A 215
HIS A 210
 None
 0.93A 2zm8A-6d6kA:
undetectable		 2zm8A-6d6kA:
13.01