SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZM7_A_ACAA502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdk L-AMINO ACID OXIDASE

(Gloydius halys) 		PF01593
(Amino_oxidase) 		5 MET A 207
TYR A 157
HIS A 223
GLY A 204
ILE A 203
 None
None
LVG  A 487 (-2.5A)
None
None
 1.48A 2zm7A-1tdkA:
0.0		 2zm7A-1tdkA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up2 CELA1 PROTEIN

(Mycobacterium
tuberculosis) 		PF01341
(Glyco_hydro_6) 		5 ALA A 340
TYR A 343
PHE A 271
GLY A 337
ILE A 285
 None
 1.49A 2zm7A-1up2A:
0.0		 2zm7A-1up2A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bk9 CG9734-PA

(Drosophila
melanogaster) 		PF00042
(Globin) 		5 ALA A  62
PHE A  42
HIS A  61
GLY A  24
ILE A  27
 None
HEM  A1154 (-3.0A)
HEM  A1154 (-3.2A)
None
None
 1.11A 2zm7A-2bk9A:
undetectable		 2zm7A-2bk9A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFITE REDUCTASE
BETA SUBUNIT

(Desulfomicrobium
norvegicum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF12838
(Fer4_7) 		5 MET A 341
ALA A 331
HIS B 197
GLY A 342
ILE A 229
 None
 1.28A 2zm7A-2xsjA:
0.0		 2zm7A-2xsjA:
21.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zm2 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Flavobacterium
sp.) 		PF00144
(Beta-lactamase) 		6 MET A 111
TRP A 186
TYR A 215
HIS A 266
GLY A 344
ILE A 345
 MES  A 504 (-3.8A)
MES  A 504 (-4.0A)
GOL  A 505 ( 4.4A)
MES  A 504 (-4.0A)
MES  A 501 (-3.5A)
MES  A 504 ( 3.7A)
 0.31A 2zm7A-2zm2A:
67.3		 2zm7A-2zm2A:
97.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 MET A 352
ALA A 351
PHE A 392
GLY A 329
ILE A 328
 None
 1.32A 2zm7A-3ce6A:
0.0		 2zm7A-3ce6A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cih PUTATIVE
ALPHA-RHAMNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		5 MET A 322
TYR A 300
PHE A 330
GLY A 318
ILE A 629
 None
 1.37A 2zm7A-3cihA:
0.0		 2zm7A-3cihA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ALA A  21
TYR A 254
ASP A 359
GLY A  12
ILE A  11
 None
 1.35A 2zm7A-3o04A:
0.0		 2zm7A-3o04A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyn CHEC, INHIBITOR OF
MCP METHYLATION /
FLIN FUSION PROTEIN

(Thermotoga
maritima) 		PF04509
(CheC) 		5 MET A 138
ALA A 141
TYR A  86
GLY A 139
ILE A 155
 None
 1.35A 2zm7A-4hynA:
0.0		 2zm7A-4hynA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00342
(PGI) 		5 MET A 489
ASP A 103
TYR A 381
GLY A 524
ILE A  72
 None
 1.33A 2zm7A-4qfhA:
undetectable		 2zm7A-4qfhA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udn PERIPLASMIC SOLUTE
BINDING PROTEIN

(Candidatus
Liberibacter
asiaticus) 		PF01297
(ZnuA) 		5 MET A 115
ALA A 114
TYR A 143
TYR A 259
ILE A 118
 None
 1.13A 2zm7A-4udnA:
undetectable		 2zm7A-4udnA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuf TETRACYCLINE
DESTRUCTASE TET(50)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 ALA A 291
TYR A 330
PHE A 167
GLY A 288
ILE A 287
 None
None
None
FAD  A 405 (-3.2A)
None
 1.30A 2zm7A-5tufA:
undetectable		 2zm7A-5tufA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugz PUTATIVE
THIOESTERASE

(Escherichia
coli) 		PF00975
(Thioesterase) 		5 TYR A 165
ASP A 111
PHE A 200
GLY A  81
ILE A  82
 None
 1.43A 2zm7A-5ugzA:
undetectable		 2zm7A-5ugzA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER

(Homo sapiens) 		no annotation 5 MET A1808
TYR A1701
PHE A1766
GLY A1809
ILE A1811
 None
 1.38A 2zm7A-5zalA:
undetectable		 2zm7A-5zalA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zhz PROBABLE
ENDONUCLEASE 4

(Mycobacterium
tuberculosis) 		no annotation 5 ALA A 207
ASP A 162
HIS A 206
GLY A 212
ILE A 214
 None
ZN  A 305 ( 3.1A)
ZN  A 306 ( 3.2A)
None
None
 1.21A 2zm7A-5zhzA:
undetectable		 2zm7A-5zhzA:
10.82