SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZM7_A_ACAA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		4 ALA A 161
TYR A  77
ILE A 176
ILE A 201
 None
 1.12A 2zm7A-1aorA:
0.0		 2zm7A-1aorA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbg CYANOGENIC
BETA-GLUCOSIDASE

(Trifolium
repens) 		PF00232
(Glyco_hydro_1) 		4 ALA A 365
TYR A 422
TRP A 369
ILE A 372
 None
 1.12A 2zm7A-1cbgA:
0.0		 2zm7A-1cbgA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eys PHOTOSYNTHETIC
REACTION CENTER

(Thermochromatium
tepidum) 		PF00124
(Photo_RC) 		4 ALA L 101
TYR L 156
ILE L  99
ILE L  97
 BPH  L 606 ( 3.9A)
BPH  L 606 (-3.7A)
None
None
 0.95A 2zm7A-1eysL:
undetectable		 2zm7A-1eysL:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inp INOSITOL
POLYPHOSPHATE
1-PHOSPHATASE

(Bos taurus) 		PF00459
(Inositol_P) 		4 ALA A  53
TYR A 161
ILE A  18
ILE A 155
 None
 1.12A 2zm7A-1inpA:
0.0		 2zm7A-1inpA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jv1 GLCNAC1P
URIDYLTRANSFERASE
ISOFORM 1: AGX1

(Homo sapiens) 		PF01704
(UDPGP) 		4 ALA A 260
TYR A 472
ILE A 143
ILE A  98
 None
 1.15A 2zm7A-1jv1A:
0.0		 2zm7A-1jv1A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		4 ALA A 162
ILE A 446
ILE A 157
HIS A 149
 None
 1.11A 2zm7A-1mqqA:
0.0		 2zm7A-1mqqA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkq HYPOTHETICAL 28.8
KDA PROTEIN IN
PSD1-SKO1 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF01557
(FAA_hydrolase) 		4 ALA A  91
TYR A   5
ILE A 212
ILE A  93
 None
 1.00A 2zm7A-1nkqA:
0.0		 2zm7A-1nkqA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh3 NON-CATALYTIC
PROTEIN 1

(Piromyces equi) 		no annotation 4 ALA A  36
TYR A  97
ILE A 127
ILE A  38
 None
 0.95A 2zm7A-1oh3A:
0.0		 2zm7A-1oh3A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1onk GALACTOSE SPECIFIC
LECTIN I B CHAIN

(Viscum album) 		PF00652
(Ricin_B_lectin) 		4 ALA B 233
TRP B 259
ILE B 225
ILE B 248
 None
 1.05A 2zm7A-1onkB:
0.0		 2zm7A-1onkB:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER

(Rhodobacter
sphaeroides) 		PF00124
(Photo_RC) 		4 ALA L  93
TYR L 148
ILE L  91
ILE L  89
 BPH  L 271 (-4.0A)
BPH  L 271 ( 4.1A)
None
None
 1.09A 2zm7A-1pssL:
undetectable		 2zm7A-1pssL:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryt RUBRERYTHRIN

(Desulfovibrio
vulgaris) 		PF02915
(Rubrerythrin) 		4 ALA A  57
TYR A 102
ILE A 124
HIS A 131
 None
None
None
FE  A 600 (-3.5A)
 1.16A 2zm7A-1rytA:
undetectable		 2zm7A-1rytA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5a HYPOTHETICAL PROTEIN
YESE

(Bacillus
subtilis) 		PF12680
(SnoaL_2) 		4 ALA A  89
TYR A 122
ILE A  88
ILE A 112
 None
 1.04A 2zm7A-1s5aA:
undetectable		 2zm7A-1s5aA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS

(Bacillus
subtilis) 		PF02898
(NO_synthase) 		4 ALA A  52
TYR A 351
ILE A 108
HIS A  92
 None
HEM  A 901 (-4.4A)
None
None
 1.10A 2zm7A-2an2A:
undetectable		 2zm7A-2an2A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avn UBIQUINONE/MENAQUINO
NE BIOSYNTHESIS
METHYLTRANSFERASE-RE
LATED PROTEIN

(Thermotoga
maritima) 		PF08241
(Methyltransf_11) 		4 ALA A 235
TRP A 233
ILE A 232
ILE A 201
 None
 1.10A 2zm7A-2avnA:
undetectable		 2zm7A-2avnA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpq ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 ALA A  66
TYR A 186
ILE A 196
ILE A  62
 None
 0.96A 2zm7A-2bpqA:
undetectable		 2zm7A-2bpqA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5q RRAA-LIKE PROTEIN
YER010C

(Saccharomyces
cerevisiae) 		PF03737
(RraA-like) 		4 ALA A 107
TYR A  66
TYR A  99
ILE A  67
 None
 1.04A 2zm7A-2c5qA:
undetectable		 2zm7A-2c5qA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glf PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Thermotoga
maritima) 		PF02127
(Peptidase_M18) 		4 ALA A 247
TYR A  25
ILE A 432
ILE A 245
 None
 1.16A 2zm7A-2glfA:
undetectable		 2zm7A-2glfA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmy HYPOTHETICAL PROTEIN
ATU0492

(Agrobacterium
fabrum) 		PF02627
(CMD) 		4 ALA A 126
ILE A 130
ILE A  35
HIS A  55
 None
 0.95A 2zm7A-2gmyA:
undetectable		 2zm7A-2gmyA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gou OXIDOREDUCTASE,
FMN-BINDING

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		4 ALA A 316
TYR A 302
ILE A 297
ILE A 319
 None
 0.90A 2zm7A-2gouA:
undetectable		 2zm7A-2gouA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 ALA A  28
TYR A 160
ILE A  41
ILE A  35
 NAP  A 523 (-3.7A)
None
NAP  A 523 (-4.4A)
NAP  A 523 (-3.8A)
 1.08A 2zm7A-2h2qA:
undetectable		 2zm7A-2h2qA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Thermus
thermophilus) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 ALA A 219
TYR A 399
ILE A 216
ILE A 214
 None
 0.90A 2zm7A-2ipcA:
undetectable		 2zm7A-2ipcA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00977
(His_biosynth) 		4 ALA A  54
TYR A  21
ILE A  28
ILE A  56
 None
 1.00A 2zm7A-2lleA:
undetectable		 2zm7A-2lleA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n4x CYTOCHROME C-TYPE
BIOGENESIS PROTEIN
(CCDA)

(Archaeoglobus
fulgidus) 		no annotation 4 ALA A 123
TYR A 142
ILE A 125
ILE A 127
 None
 1.15A 2zm7A-2n4xA:
undetectable		 2zm7A-2n4xA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nnj CYTOCHROME P450 2C8

(Homo sapiens) 		PF00067
(p450) 		4 ALA A 436
TRP A 120
ILE A 434
HIS A 368
 HEM  A 500 (-3.7A)
HEM  A 500 (-4.0A)
None
HEM  A 500 (-3.8A)
 1.10A 2zm7A-2nnjA:
undetectable		 2zm7A-2nnjA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 4 ALA A1011
TYR A 987
ILE A1025
ILE A 822
 None
 1.15A 2zm7A-2po4A:
undetectable		 2zm7A-2po4A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8w AGR_C_1641P

(Agrobacterium
fabrum) 		PF00701
(DHDPS) 		4 ALA A 192
TYR A 240
ILE A 220
ILE A 165
 None
 1.13A 2zm7A-2r8wA:
undetectable		 2zm7A-2r8wA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgi PYRUVATE KINASE
ISOZYMES R/L

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		4 ALA A 346
TYR A 218
ILE A 344
ILE A 342
 None
 1.07A 2zm7A-2vgiA:
undetectable		 2zm7A-2vgiA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzb PUTATIVE
BACTERIOFERRITIN-REL
ATED PROTEIN

(Bacteroides
fragilis) 		PF00210
(Ferritin) 		4 ALA A  66
TYR A 121
ILE A 142
HIS A 149
 None
None
None
FE  A6205 (-3.3A)
 1.08A 2zm7A-2vzbA:
undetectable		 2zm7A-2vzbA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xh6 HEAT-LABILE
ENTEROTOXIN B CHAIN

(Clostridium
perfringens) 		PF03505
(Clenterotox) 		4 ALA A 302
TYR A 312
ILE A 258
HIS A 285
 None
 1.16A 2zm7A-2xh6A:
undetectable		 2zm7A-2xh6A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Candida
albicans) 		PF01704
(UDPGP) 		4 ALA A 264
TYR A 467
ILE A 144
ILE A  99
 None
 1.10A 2zm7A-2yqhA:
undetectable		 2zm7A-2yqhA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvu PROBABLE
ADENYLYL-SULFATE
KINASE

(Aeropyrum
pernix) 		PF01583
(APS_kinase) 		4 ALA A  78
TRP A  76
ILE A 106
ILE A 112
 None
 1.12A 2zm7A-2yvuA:
undetectable		 2zm7A-2yvuA:
18.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zm2 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Flavobacterium
sp.) 		PF00144
(Beta-lactamase) 		5 TYR A 215
TRP A 331
ILE A 343
ILE A 345
HIS A 375
 GOL  A 505 ( 4.4A)
MES  A 501 (-4.0A)
MES  A 501 (-4.2A)
MES  A 504 ( 3.7A)
MES  A 501 ( 4.2A)
 0.21A 2zm7A-2zm2A:
67.3		 2zm7A-2zm2A:
97.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqk POLY(A) POLYMERASE

(Escherichia
coli) 		PF01743
(PolyA_pol)
PF12626
(PolyA_pol_arg_C)
PF12627
(PolyA_pol_RNAbd) 		4 ALA A 201
TYR A 191
ILE A 212
ILE A 220
 None
 1.09A 2zm7A-3aqkA:
undetectable		 2zm7A-3aqkA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayn RHODOPSIN

(Todarodes
pacificus) 		PF00001
(7tm_1) 		4 ALA A 167
TYR A 177
ILE A 168
ILE A 117
 None
 1.18A 2zm7A-3aynA:
undetectable		 2zm7A-3aynA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c24 PUTATIVE
OXIDOREDUCTASE

(Jannaschia sp.
CCS1) 		PF03807
(F420_oxidored)
PF16896
(PGDH_C) 		4 ALA A  38
TRP A  63
ILE A  40
ILE A  15
 None
 1.19A 2zm7A-3c24A:
undetectable		 2zm7A-3c24A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcl TM1086

(Thermotoga
maritima) 		PF14505
(DUF4438) 		4 ALA A 200
TYR A  54
ILE A 198
HIS A 243
 None
 1.06A 2zm7A-3dclA:
undetectable		 2zm7A-3dclA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqp OXIDOREDUCTASE YLBE

(Lactococcus
lactis) 		PF13460
(NAD_binding_10) 		4 ALA A  66
TYR A  25
ILE A 102
ILE A   3
 None
 1.15A 2zm7A-3dqpA:
undetectable		 2zm7A-3dqpA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ALA A 141
TYR A 174
ILE A 291
HIS A  28
 None
 1.18A 2zm7A-3dy5A:
undetectable		 2zm7A-3dy5A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF00857
(Isochorismatase) 		4 ALA A 107
TYR A  86
ILE A 110
ILE A 104
 None
 1.00A 2zm7A-3eefA:
undetectable		 2zm7A-3eefA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		4 ALA A1390
TYR A1529
ILE A1019
ILE A1403
 None
 0.96A 2zm7A-3hmjA:
undetectable		 2zm7A-3hmjA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hol TBPB

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 ALA A  46
TYR A 258
TYR A 124
ILE A  71
 None
 0.97A 2zm7A-3holA:
undetectable		 2zm7A-3holA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iic CHEC DOMAIN PROTEIN

(Shewanella
loihica) 		PF13690
(CheX) 		4 ALA A  38
ILE A 126
ILE A 136
HIS A 128
 None
 1.02A 2zm7A-3iicA:
undetectable		 2zm7A-3iicA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE

(Pimelobacter
simplex) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		4 ALA A  75
TYR A  40
ILE A  74
ILE A  78
 None
 1.16A 2zm7A-3k30A:
undetectable		 2zm7A-3k30A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Bacillus
cytotoxicus) 		PF13377
(Peripla_BP_3) 		4 ALA A 135
ILE A 169
ILE A 137
HIS A 171
 None
 1.06A 2zm7A-3k4hA:
undetectable		 2zm7A-3k4hA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5r CADHERIN 13

(Mus musculus) 		PF00028
(Cadherin) 		4 ALA A 211
ILE A 113
ILE A 213
HIS A 115
 None
 1.04A 2zm7A-3k5rA:
undetectable		 2zm7A-3k5rA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lew SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ALA A 170
TYR A 150
TYR A 112
ILE A 172
 None
None
1PE  A   5 (-3.6A)
None
 1.16A 2zm7A-3lewA:
undetectable		 2zm7A-3lewA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mse CALCIUM-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
falciparum) 		PF10591
(SPARC_Ca_bdg)
PF13202
(EF-hand_5) 		4 ALA B  27
TYR B  12
ILE B  25
ILE B  23
 None
 1.07A 2zm7A-3mseB:
undetectable		 2zm7A-3mseB:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqk UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF14274
(DUF4361)
PF16343
(DUF4973) 		4 ALA A  37
TYR A  61
ILE A  39
ILE A  49
 None
 1.05A 2zm7A-3nqkA:
undetectable		 2zm7A-3nqkA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE

(Caulobacter
vibrioides) 		PF00348
(polyprenyl_synt) 		4 ALA A 283
TYR A 227
ILE A 255
ILE A 287
 None
 0.93A 2zm7A-3oyrA:
undetectable		 2zm7A-3oyrA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q98 TRANSCARBAMYLASE

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ALA A 333
TYR A 327
ILE A 335
HIS A 311
 None
 0.96A 2zm7A-3q98A:
undetectable		 2zm7A-3q98A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qhb SYMERYTHRIN

(Cyanophora
paradoxa) 		PF02915
(Rubrerythrin) 		4 ALA A  75
TYR A 136
ILE A 158
HIS A 165
 None
None
None
FE  A 182 (-3.3A)
 0.98A 2zm7A-3qhbA:
undetectable		 2zm7A-3qhbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkw NUCLEOTIDE SUGAR
SYNTHETASE-LIKE
PROTEIN

(Streptococcus
parasanguinis) 		no annotation 4 ALA A 165
TYR A 296
ILE A 255
HIS A 172
 None
 1.14A 2zm7A-3qkwA:
undetectable		 2zm7A-3qkwA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg9 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
brucei) 		PF00186
(DHFR_1) 		4 ALA A  34
TYR A 166
ILE A  47
ILE A  41
 WRA  A 602 (-3.9A)
None
WRA  A 602 ( 4.5A)
NDP  A 601 (-3.5A)
 1.02A 2zm7A-3rg9A:
undetectable		 2zm7A-3rg9A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3roh LEUCOTOXIN LUKEV

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		4 ALA A  73
TYR A 141
TYR A  69
ILE A 122
 None
 1.18A 2zm7A-3rohA:
undetectable		 2zm7A-3rohA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ryl PROTEIN VPA1370

(Vibrio
parahaemolyticus) 		no annotation 4 ALA A 381
ILE A 378
ILE A 288
HIS A 285
 None
 1.09A 2zm7A-3rylA:
undetectable		 2zm7A-3rylA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rys ADENOSINE DEAMINASE
1

(Paenarthrobacter
aurescens) 		PF00962
(A_deaminase) 		4 ALA A 141
TYR A 186
ILE A 139
ILE A 168
 None
 0.99A 2zm7A-3rysA:
undetectable		 2zm7A-3rysA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		4 ALA A 437
TRP A 121
ILE A 435
HIS A 369
 HEM  A 500 (-3.4A)
HEM  A 500 (-3.9A)
None
HEM  A 500 (-3.8A)
 1.12A 2zm7A-3tk3A:
undetectable		 2zm7A-3tk3A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txy ISOCHORISMATASE
FAMILY PROTEIN
FAMILY

(Burkholderia
thailandensis) 		PF00857
(Isochorismatase) 		4 ALA A  11
TYR A 148
ILE A  53
ILE A 125
 None
 1.14A 2zm7A-3txyA:
undetectable		 2zm7A-3txyA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vns NRPS ADENYLATION
PROTEIN CYTC1

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ALA A 217
TYR A  43
TRP A 215
ILE A 214
 None
 0.99A 2zm7A-3vnsA:
undetectable		 2zm7A-3vnsA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcz ALDO-KETO REDUCTASE
2E

(Bombyx mori) 		PF00248
(Aldo_ket_red) 		4 ALA A 205
ILE A 255
ILE A 257
HIS A  51
 None
None
NAP  A 401 (-3.5A)
None
 1.11A 2zm7A-3wczA:
undetectable		 2zm7A-3wczA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfa ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 ALA A 601
TYR A 590
TYR A 607
ILE A 328
 None
 1.16A 2zm7A-3wfaA:
undetectable		 2zm7A-3wfaA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF04054
(Not1) 		4 TYR A1965
TRP A2001
ILE A1948
HIS A1998
 None
 1.01A 2zm7A-4by6A:
undetectable		 2zm7A-4by6A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dg8 PA1221

(Pseudomonas
aeruginosa) 		PF00501
(AMP-binding) 		4 ALA A 223
TYR A  53
TRP A 221
ILE A 220
 None
 1.16A 2zm7A-4dg8A:
undetectable		 2zm7A-4dg8A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dok SIMILARITY TO
CHALCONE-FLAVONONE
ISOMERASE

(Arabidopsis
thaliana) 		PF02431
(Chalcone) 		4 TYR A 185
TYR A 101
ILE A 158
ILE A  88
 None
 1.16A 2zm7A-4dokA:
undetectable		 2zm7A-4dokA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM6
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM7

(Schizosaccharomyces
pombe) 		PF01423
(LSM) 		4 ALA B  60
TYR B  27
ILE C  96
ILE B  62
 None
 1.13A 2zm7A-4emkB:
undetectable		 2zm7A-4emkB:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF

(Thermococcus
kodakarensis) 		PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 TYR A 309
ILE A 362
ILE A 221
HIS A 358
 None
 1.01A 2zm7A-4g9iA:
undetectable		 2zm7A-4g9iA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 ALA A  49
ILE A  20
ILE A  51
HIS A  22
 None
 1.12A 2zm7A-4hooA:
undetectable		 2zm7A-4hooA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jja HYPOTHETICAL PROTEIN

(Bacteroides
fragilis) 		PF07075
(DUF1343) 		4 ALA A  44
ILE A  72
ILE A 124
HIS A  57
 None
 1.13A 2zm7A-4jjaA:
undetectable		 2zm7A-4jjaA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7o IRON-BINDING PROTEIN

(Staphylococcus
epidermidis) 		PF01497
(Peripla_BP_2) 		4 ALA A 260
TYR A 245
ILE A 233
ILE A 266
 None
 1.06A 2zm7A-4m7oA:
undetectable		 2zm7A-4m7oA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5h HEAT-LABILE
ENTEROTOXIN B CHAIN

(Clostridium
perfringens) 		PF03505
(Clenterotox) 		4 ALA A 302
TYR A 312
ILE A 258
HIS A 285
 None
 1.15A 2zm7A-4p5hA:
undetectable		 2zm7A-4p5hA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psu ALPHA/BETA HYDROLASE

(Rhodopseudomonas
palustris) 		PF12697
(Abhydrolase_6) 		4 ALA A 289
TYR A  67
ILE A 285
ILE A 134
 None
 1.18A 2zm7A-4psuA:
undetectable		 2zm7A-4psuA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q29 PLU4264 PROTEIN

(Photorhabdus
laumondii) 		PF07883
(Cupin_2) 		4 ALA A  65
ILE A  93
ILE A  67
HIS A  91
 None
 1.16A 2zm7A-4q29A:
undetectable		 2zm7A-4q29A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		4 ALA A 357
TYR A 412
TRP A 361
ILE A 364
 None
None
EPE  A 503 ( 3.5A)
None
 1.16A 2zm7A-4re2A:
undetectable		 2zm7A-4re2A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnu ASPARTOACYLASE

(Homo sapiens) 		PF04952
(AstE_AspA) 		4 ALA A 296
TYR A 155
ILE A 226
HIS A 159
 None
 1.18A 2zm7A-4tnuA:
undetectable		 2zm7A-4tnuA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udn PERIPLASMIC SOLUTE
BINDING PROTEIN

(Candidatus
Liberibacter
asiaticus) 		PF01297
(ZnuA) 		4 ALA A 114
TYR A 143
TYR A 259
ILE A 118
 None
 0.94A 2zm7A-4udnA:
undetectable		 2zm7A-4udnA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA+,K+-ATPASE BETA
SUBUNIT

(Squalus
acanthias) 		PF00287
(Na_K-ATPase) 		4 ALA B 216
TYR B 231
ILE B 276
ILE B 229
 None
 1.08A 2zm7A-5aw4B:
undetectable		 2zm7A-5aw4B:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bmo PUTATIVE
UNCHARACTERIZED
PROTEIN LNMX

(Streptomyces
atroolivaceus) 		PF02585
(PIG-L) 		4 ALA A  29
TYR A  45
ILE A  25
HIS A 200
 None
 1.13A 2zm7A-5bmoA:
undetectable		 2zm7A-5bmoA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Cryptococcus
neoformans) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ALA A 358
TYR A 149
TYR A 109
ILE A 136
 None
 1.19A 2zm7A-5cefA:
undetectable		 2zm7A-5cefA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecx DEHYDROFOLATE
REDUCTASE TYPE I

(Klebsiella
pneumoniae) 		PF00186
(DHFR_1) 		4 ALA A   7
TYR A 102
ILE A  20
ILE A  14
 5N1  A 202 ( 3.5A)
None
NAP  A 201 (-4.1A)
NAP  A 201 (-3.9A)
 1.14A 2zm7A-5ecxA:
undetectable		 2zm7A-5ecxA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE

(Ureibacillus
thermosphaericus) 		PF01113
(DapB_N)
PF16654
(DAPDH_C) 		4 ALA A 117
TYR A 102
ILE A  90
ILE A 119
 None
 0.86A 2zm7A-5gz1A:
undetectable		 2zm7A-5gz1A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqb ALPHA-GLUCOSIDASE

(Pseudoalteromonas
sp. K8) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 ALA A 550
TYR A 539
TYR A 556
ILE A 286
 None
 1.11A 2zm7A-5hqbA:
undetectable		 2zm7A-5hqbA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2g DIOL DEHYDRATASE

(Roseburia
inulinivorans) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ALA A 312
TYR A 298
ILE A 316
ILE A   9
 None
 1.19A 2zm7A-5i2gA:
undetectable		 2zm7A-5i2gA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6e ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		4 TYR A1275
TYR A1272
ILE A1341
HIS A1321
 None
MLI  A1501 (-4.4A)
None
None
 1.06A 2zm7A-5i6eA:
undetectable		 2zm7A-5i6eA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6q CELL WALL BINDING
PROTEIN CWP8

(Clostridioides
difficile) 		PF04122
(CW_binding_2) 		4 ALA A 440
TYR A 515
ILE A 438
ILE A 552
 None
 1.13A 2zm7A-5j6qA:
undetectable		 2zm7A-5j6qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbh 30S RIBOSOMAL
PROTEIN ES24

(Pyrococcus
abyssi) 		PF01282
(Ribosomal_S24e) 		4 TYR V  59
ILE V  23
ILE V  64
HIS V  25
 U  2 572 ( 4.5A)
None
None
None
 1.05A 2zm7A-5jbhV:
undetectable		 2zm7A-5jbhV:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens) 		PF03538
(VRP1) 		4 ALA A2389
TYR A2341
ILE A2507
ILE A2357
 None
 1.19A 2zm7A-5lkiA:
undetectable		 2zm7A-5lkiA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m45 ACETONE CARBOXYLASE
BETA SUBUNIT

(Xanthobacter
autotrophicus) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 ALA B 350
ILE B 390
ILE B 310
HIS B 394
 None
 0.95A 2zm7A-5m45B:
undetectable		 2zm7A-5m45B:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9x ADENYLATION DOMAIN

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ALA A 221
TYR A  46
TRP A 219
ILE A 218
 None
 1.11A 2zm7A-5n9xA:
undetectable		 2zm7A-5n9xA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no8 BACCELL_00875

(Bacteroides
cellulosilyticus) 		no annotation 4 ALA A 219
TYR A  70
ILE A 202
ILE A 217
 None
 1.14A 2zm7A-5no8A:
undetectable		 2zm7A-5no8A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2

(Homo sapiens) 		PF04056
(Ssl1) 		4 TYR E 219
ILE E 199
ILE E 169
HIS E 235
 None
 1.10A 2zm7A-5of4E:
undetectable		 2zm7A-5of4E:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um8 GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 ALA G 329
TYR G 177
ILE G 443
ILE G 420
 None
 1.14A 2zm7A-5um8G:
undetectable		 2zm7A-5um8G:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA

(Yersinia pestis) 		PF01297
(ZnuA) 		4 ALA A 149
TYR A 178
TYR A 294
ILE A 153
 None
 0.92A 2zm7A-5uygA:
undetectable		 2zm7A-5uygA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 ALA A 223
TYR A 135
ILE A 222
ILE A 193
 None
 1.15A 2zm7A-5weoA:
undetectable		 2zm7A-5weoA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwo ESSENTIAL NUCLEAR
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF05291
(Bystin) 		4 ALA A 420
TYR A 393
ILE A 416
ILE A 372
 None
 1.05A 2zm7A-5wwoA:
undetectable		 2zm7A-5wwoA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029

(Streptococcus
pneumoniae) 		no annotation 4 ALA A 400
TYR A 420
ILE A 309
ILE A 403
 None
 1.16A 2zm7A-5xj1A:
undetectable		 2zm7A-5xj1A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnf PHOSPHOETHANOLAMINE
TRANSFERASE

(Moraxella sp.
HMSC061H09) 		no annotation 4 ALA A 275
TYR A 495
ILE A 525
HIS A 549
 None
 0.63A 2zm7A-6bnfA:
undetectable		 2zm7A-6bnfA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxm DIHYDROFOLATE
REDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 4 ALA A   8
TYR A  98
ILE A  21
ILE A  15
 NAP  A 201 (-3.9A)
None
NAP  A 201 (-3.8A)
NAP  A 201 (-4.1A)
 1.12A 2zm7A-6cxmA:
undetectable		 2zm7A-6cxmA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4c ALPHA-GALACTOSIDASE

(Nicotiana
benthamiana) 		no annotation 4 ALA B 399
TYR B 409
ILE B 364
ILE B 397
 None
 1.08A 2zm7A-6f4cB:
undetectable		 2zm7A-6f4cB:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fai ESSENTIAL NUCLEAR
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 4 ALA i 420
TYR i 393
ILE i 416
ILE i 372
 None
 1.04A 2zm7A-6faii:
undetectable		 2zm7A-6faii:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gdg TRXA,ADENOSINE
RECEPTOR A2A

(Escherichia
coli;
Homo sapiens) 		no annotation 4 TYR A 288
TYR A 197
ILE A 100
ILE A  98
 None
 1.16A 2zm7A-6gdgA:
undetectable		 2zm7A-6gdgA:
10.97