SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZLC_A_VDXA500_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ejb LUMAZINE SYNTHASE

(Saccharomyces
cerevisiae) 		PF00885
(DMRL_synthase) 		4 LEU A 109
ILE A  31
ARG A  28
TRP A  26
 None
None
None
INJ  A 200 (-3.9A)
 1.43A 2zlcA-1ejbA:
undetectable		 2zlcA-1ejbA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8r L-AMINO ACID OXIDASE

(Calloselasma
rhodostoma) 		PF01593
(Amino_oxidase) 		4 LEU A  91
ILE A 430
ARG A 322
TRP A 420
 None
FAD  A 527 (-4.7A)
CIT  A 526 (-3.3A)
FAD  A 527 (-3.8A)
 1.45A 2zlcA-1f8rA:
0.0		 2zlcA-1f8rA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		4 LEU A 321
ILE A 240
ARG A 405
TYR A 416
 None
 1.45A 2zlcA-1hg4A:
19.1		 2zlcA-1hg4A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jiu DNA
BETA-GLUCOSYLTRANSFE
RASE

(Escherichia
virus T4) 		PF09198
(T4-Gluco-transf) 		4 LEU A 324
ILE A 255
ARG A 269
TRP A 271
 None
None
UDP  A 353 (-3.9A)
None
 1.12A 2zlcA-1jiuA:
0.0		 2zlcA-1jiuA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE

(Thermococcus
litoralis) 		PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926) 		4 LEU A 134
ILE A 177
ARG A 182
TYR A 141
 None
 1.43A 2zlcA-1k1xA:
0.0		 2zlcA-1k1xA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcj NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		4 LEU A 266
ILE A 262
ARG A 257
TYR A 214
 None
 1.50A 2zlcA-1vcjA:
0.0		 2zlcA-1vcjA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3n ALGQ1

(Sphingomonas
sp. A1) 		PF01547
(SBP_bac_1) 		4 LEU A 160
ILE A 184
ARG A 250
TYR A 139
 None
 1.27A 2zlcA-1y3nA:
0.0		 2zlcA-1y3nA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		4 LEU A 277
ILE A 125
ARG A 111
TYR A 122
 None
 1.41A 2zlcA-1z26A:
undetectable		 2zlcA-1z26A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adf 82D6A3 IGG

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 124
ILE L 149
ARG L 154
TRP L 147
 None
 1.17A 2zlcA-2adfL:
undetectable		 2zlcA-2adfL:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqx PREDICTED: INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE B

(Mus musculus) 		PF03770
(IPK) 		4 LEU A 704
ILE A 929
ARG A 851
TYR A 921
 None
 1.24A 2zlcA-2aqxA:
0.0		 2zlcA-2aqxA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ct8 METHIONYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 LEU A 475
ILE A 402
ARG A 324
TYR A  37
 None
 1.43A 2zlcA-2ct8A:
undetectable		 2zlcA-2ct8A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1n PEX

(Synechococcus
elongatus) 		PF03551
(PadR) 		4 LEU A  81
ILE A  93
ARG A 120
TYR A 111
 None
 1.20A 2zlcA-2e1nA:
undetectable		 2zlcA-2e1nA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6h MYOSIN-2

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		4 LEU X 180
ILE X 228
TRP X 293
TYR X 259
 None
 1.28A 2zlcA-2f6hX:
undetectable		 2zlcA-2f6hX:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu4 DIHYDROXYACETONE
KINASE

(Lactococcus
lactis) 		PF02733
(Dak1) 		4 LEU A 108
ILE A  88
ARG A  89
TYR A 127
 None
 1.26A 2zlcA-2iu4A:
undetectable		 2zlcA-2iu4A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2llz UNCHARACTERIZED
PROTEIN YJDK

(Escherichia
coli) 		PF11080
(GhoS) 		4 LEU A  52
ILE A  72
ARG A  73
TYR A  34
 None
 1.27A 2zlcA-2llzA:
undetectable		 2zlcA-2llzA:
22.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2o4j VITAMIN D3 RECEPTOR

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		5 LEU A 223
ILE A 267
ARG A 270
TRP A 282
TYR A 397
 None
VD4  A 500 ( 4.7A)
VD4  A 500 ( 4.0A)
VD4  A 500 ( 3.7A)
None
 0.13A 2zlcA-2o4jA:
41.7		 2zlcA-2o4jA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oh1 ACETYLTRANSFERASE,
GNAT FAMILY

(Listeria
monocytogenes) 		no annotation 4 LEU A 150
ILE A 139
TRP A  94
TYR A 157
 None
None
None
EDO  A 181 (-4.7A)
 1.40A 2zlcA-2oh1A:
undetectable		 2zlcA-2oh1A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plc PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C

(Listeria
monocytogenes) 		PF00388
(PI-PLC-X) 		4 LEU A 102
ILE A 121
ARG A  79
TYR A 146
 None
 1.37A 2zlcA-2plcA:
undetectable		 2zlcA-2plcA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnd V-SET AND
IMMUNOGLOBULIN
DOMAIN CONTAINING 4

(Mus musculus) 		PF07686
(V-set) 		4 LEU A  84
ILE A  58
ARG A  64
TYR A  92
 None
 1.30A 2zlcA-2pndA:
undetectable		 2zlcA-2pndA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2py6 METHYLTRANSFERASE
FKBM

(Methylobacillus
flagellatus) 		PF05050
(Methyltransf_21) 		4 LEU A 116
ILE A  98
ARG A 102
TYR A  92
 None
 1.44A 2zlcA-2py6A:
undetectable		 2zlcA-2py6A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vak SIGMA A

(Avian
orthoreovirus) 		PF03084
(Sigma_1_2) 		4 LEU A  28
ILE A 318
TRP A 132
TYR A  75
 None
 1.36A 2zlcA-2vakA:
undetectable		 2zlcA-2vakA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsa MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		4 LEU A  55
ILE A 681
ARG A 683
TYR A 718
 None
 1.47A 2zlcA-2vsaA:
undetectable		 2zlcA-2vsaA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1m METHIONYL-TRNA
SYNTHETASE

(Mycolicibacterium
smegmatis) 		PF09334
(tRNA-synt_1g) 		4 LEU A 168
ILE A 107
ARG A 110
TRP A 108
 None
 1.47A 2zlcA-2x1mA:
undetectable		 2zlcA-2x1mA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 LEU A  74
ILE A  62
TRP A  41
TYR A  89
 None
 1.06A 2zlcA-2x3kA:
undetectable		 2zlcA-2x3kA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		4 LEU A 393
ILE A 439
ARG A 435
TRP A 437
 None
 1.35A 2zlcA-3ayfA:
undetectable		 2zlcA-3ayfA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8b CYSQ, SULFITE
SYNTHESIS PATHWAY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00459
(Inositol_P) 		4 LEU A 139
ILE A  47
TRP A  78
TYR A 114
 None
 1.36A 2zlcA-3b8bA:
undetectable		 2zlcA-3b8bA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3u PEPTIDE DEFORMYLASE

(Mycobacterium
tuberculosis) 		PF01327
(Pep_deformylase) 		4 ILE A  57
ARG A   7
TRP A 186
TYR A  41
 NVC  A 202 (-4.8A)
None
None
None
 1.47A 2zlcA-3e3uA:
undetectable		 2zlcA-3e3uA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6m 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Yersinia pestis) 		PF02542
(YgbB) 		4 LEU A 156
ILE A 129
ARG A 115
TYR A  83
 None
 1.29A 2zlcA-3f6mA:
undetectable		 2zlcA-3f6mA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5w MULTICOPPER OXIDASE
TYPE 1

(Nitrosomonas
europaea) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A  50
ILE A 183
ARG A 234
TRP A 144
 None
 1.29A 2zlcA-3g5wA:
undetectable		 2zlcA-3g5wA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipl 2-SUCCINYLBENZOATE--
COA LIGASE

(Staphylococcus
aureus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 101
ILE A 232
ARG A 231
TYR A 212
 None
 1.10A 2zlcA-3iplA:
undetectable		 2zlcA-3iplA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtz INTEGRASE

(Yersinia pestis) 		PF13356
(Arm-DNA-bind_3) 		4 LEU A  53
ILE A   8
ARG A   9
TYR A  27
 None
 1.46A 2zlcA-3jtzA:
undetectable		 2zlcA-3jtzA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll7 PUTATIVE
METHYLTRANSFERASE

(Porphyromonas
gingivalis) 		no annotation 4 LEU A  47
ILE A  33
ARG A  38
TYR A  65
 None
 1.42A 2zlcA-3ll7A:
undetectable		 2zlcA-3ll7A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(marine
actinobacterium
PHSC20C1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 328
ILE A 157
ARG A 344
TRP A 349
 None
 1.13A 2zlcA-3msyA:
undetectable		 2zlcA-3msyA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx3 SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		4 LEU A 505
ILE A 420
TRP A 360
TYR A 443
 None
 1.24A 2zlcA-3mx3A:
undetectable		 2zlcA-3mx3A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nad FERULATE
DECARBOXYLASE

(Bacillus
pumilus) 		PF05870
(PA_decarbox) 		4 LEU A  72
ILE A 144
ARG A  44
TYR A  19
 None
 1.34A 2zlcA-3nadA:
undetectable		 2zlcA-3nadA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naw SECRETED EFFECTOR
PROTEIN

(Escherichia
coli) 		PF00805
(Pentapeptide)
PF13979
(SopA_C)
PF13981
(SopA) 		4 LEU A 689
ILE A 711
TRP A 658
TYR A 696
 None
 1.22A 2zlcA-3nawA:
undetectable		 2zlcA-3nawA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 LEU A  23
ILE A 499
ARG A  13
TRP A 504
 None
 1.48A 2zlcA-3ne5A:
1.1		 2zlcA-3ne5A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no6 TRANSCRIPTIONAL
ACTIVATOR TENA

(Staphylococcus
epidermidis) 		PF03070
(TENA_THI-4) 		4 LEU A  89
ILE A  18
ARG A 209
TYR A 167
 None
 1.47A 2zlcA-3no6A:
2.8		 2zlcA-3no6A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 316
ILE A 202
ARG A 204
TYR A 333
 None
None
SEP  A 241 ( 3.4A)
None
 1.48A 2zlcA-3nuuA:
undetectable		 2zlcA-3nuuA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5p TAXADIENE SYNTHASE

(Taxus
brevifolia) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 LEU A 755
ILE A 700
TRP A 694
TYR A 778
 None
 1.36A 2zlcA-3p5pA:
1.6		 2zlcA-3p5pA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6g HEAVY CHAIN OF FAB
OF RHESUS MAB 2.5B

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H  80
ILE H  95
TRP H 103
TYR H  59
 None
 1.31A 2zlcA-3q6gH:
undetectable		 2zlcA-3q6gH:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t12 GLIDING PROTEIN MGLB

(Thermus
thermophilus) 		PF03259
(Robl_LC7) 		4 LEU B 115
ARG B  25
TRP B  49
TYR B  95
 None
 1.37A 2zlcA-3t12B:
undetectable		 2zlcA-3t12B:
18.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wgp VITAMIN D3 RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 227
ILE A 271
ARG A 274
TRP A 286
TYR A 401
 None
ED9  A 501 (-4.5A)
ED9  A 501 (-2.9A)
ED9  A 501 (-3.5A)
None
 0.36A 2zlcA-3wgpA:
38.7		 2zlcA-3wgpA:
90.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 LEU B1302
ILE B1020
TRP B1526
TYR B1026
 None
 1.43A 2zlcA-3zefB:
undetectable		 2zlcA-3zefB:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhe PROTEIN SMG-7

(Caenorhabditis
elegans) 		PF10373
(EST1_DNA_bind) 		4 LEU B  82
ILE B 159
ARG B 126
TYR B 152
 None
 1.49A 2zlcA-3zheB:
undetectable		 2zlcA-3zheB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aej COLLAGEN
ALPHA-1(III) CHAIN

(Homo sapiens) 		PF01410
(COLFI) 		4 LEU A  87
ILE A 223
TRP A  94
TYR A 119
 None
 1.26A 2zlcA-4aejA:
undetectable		 2zlcA-4aejA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoe ACETYLCHOLINE-BINDIN
G PROTEIN TYPE 2

(Biomphalaria
glabrata) 		PF02931
(Neur_chan_LBD) 		4 LEU A 155
ILE A  23
ARG A  63
TYR A 148
 None
 1.39A 2zlcA-4aoeA:
undetectable		 2zlcA-4aoeA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce7 UNSATURATED
3S-RHAMNOGLYCURONYL
HYDROLASE

(Nonlabens
ulvanivorans) 		PF07470
(Glyco_hydro_88) 		4 LEU A 231
ARG A 219
TRP A 146
TYR A  95
 None
 1.50A 2zlcA-4ce7A:
undetectable		 2zlcA-4ce7A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 LEU A 524
ILE A 632
ARG A 635
TYR A 610
 None
 1.47A 2zlcA-4iigA:
undetectable		 2zlcA-4iigA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Escherichia
coli) 		PF03331
(LpxC) 		4 LEU A  26
ILE A  89
ARG A   5
TYR A  39
 None
 1.28A 2zlcA-4isaA:
undetectable		 2zlcA-4isaA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzw GLUTATHIONE
S-TRANSFERASE

(Streptococcus
sanguinis) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 LEU A 221
ILE A 244
ARG A 247
TYR A 213
 None
 1.38A 2zlcA-4mzwA:
undetectable		 2zlcA-4mzwA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pb0 AB53 LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 125
ILE L 150
ARG L 155
TRP L 148
 None
 1.46A 2zlcA-4pb0L:
undetectable		 2zlcA-4pb0L:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmu ENDO-1,4-BETA-XYLANA
SE A

(Xanthomonas
citri) 		PF00331
(Glyco_hydro_10) 		4 LEU A 195
ILE A 156
ARG A 164
TRP A 168
 None
 1.41A 2zlcA-4pmuA:
undetectable		 2zlcA-4pmuA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pua GLUTATHIONE
S-TRANSFERASE

(Streptococcus
pneumoniae) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 LEU A 222
ILE A 245
ARG A 248
TYR A 214
 None
 1.37A 2zlcA-4puaA:
undetectable		 2zlcA-4puaA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb9 ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycolicibacterium
smegmatis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 LEU A 254
ILE A 174
ARG A 177
TRP A 178
 None
 1.24A 2zlcA-4qb9A:
undetectable		 2zlcA-4qb9A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh0 SPORE PHOTOPRODUCT
LYASE

(Geobacillus
thermodenitrificans) 		no annotation 4 LEU A 320
ILE A 196
ARG A 215
TYR A 327
 None
 1.46A 2zlcA-4rh0A:
undetectable		 2zlcA-4rh0A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 LEU A2504
ILE A2466
TRP A2460
TYR A2442
 None
 1.49A 2zlcA-4rh7A:
undetectable		 2zlcA-4rh7A:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3k SPORE GERMINATION
PROTEIN YAAH

(Bacillus
megaterium) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		4 LEU A 323
ILE A 318
ARG A 402
TYR A 283
 None
None
SO4  A 501 (-2.9A)
None
 1.40A 2zlcA-4s3kA:
undetectable		 2zlcA-4s3kA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmu RECQ

(Cronobacter
sakazakii) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		4 LEU A  85
ILE A 121
ARG A 125
TYR A  57
 None
 1.20A 2zlcA-4tmuA:
undetectable		 2zlcA-4tmuA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upk PHOSPHONATE
MONOESTER HYDROLASE

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		4 LEU A 193
ILE A 313
ARG A 346
TYR A 210
 None
 1.48A 2zlcA-4upkA:
undetectable		 2zlcA-4upkA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 LEU A 806
ILE A 839
ARG A 860
TRP A 858
 None
 1.21A 2zlcA-4xriA:
undetectable		 2zlcA-4xriA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y05 KINESIN-LIKE PROTEIN
KIF2C

(Homo sapiens) 		PF00225
(Kinesin) 		4 LEU A 493
ILE A 259
ARG A 258
TYR A 581
 None
 1.25A 2zlcA-4y05A:
undetectable		 2zlcA-4y05A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ziu UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF07678
(A2M_comp) 		4 LEU A1569
ILE A1511
ARG A1509
TRP A1533
 None
 1.43A 2zlcA-4ziuA:
undetectable		 2zlcA-4ziuA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		4 LEU A1569
ILE A1511
ARG A1509
TRP A1533
 None
 1.50A 2zlcA-5a42A:
undetectable		 2zlcA-5a42A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fpr DNA LIGASE

(Staphylococcus
aureus) 		PF01653
(DNA_ligase_aden) 		4 LEU A  82
ILE A 277
ARG A 270
TYR A 219
 None
 1.46A 2zlcA-5fprA:
undetectable		 2zlcA-5fprA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai TAIL FIBER PROTEIN

(Salmonella
virus P22) 		no annotation 4 LEU Y 145
ILE Y 181
ARG Y 266
TYR Y 151
 None
 1.35A 2zlcA-5gaiY:
undetectable		 2zlcA-5gaiY:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrp MARBERG VIRUS
MONOCLONAL ANTIBODY
MR78 FAB HEAVY CHAIN

(Homo sapiens) 		no annotation 4 LEU H  91
ILE H 109
TRP H 139
TYR H  70
 None
 1.25A 2zlcA-5jrpH:
undetectable		 2zlcA-5jrpH:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kol UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		PF02464
(CinA) 		4 LEU A  28
ILE A  17
ARG A 161
TYR A  60
 None
CL  A 201 (-4.6A)
None
None
 1.34A 2zlcA-5kolA:
undetectable		 2zlcA-5kolA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oar BETA-HEXOSAMINIDASE

(Aspergillus
oryzae) 		no annotation 4 LEU B 537
ILE B 264
ARG B 262
TYR B 184
 None
 1.39A 2zlcA-5oarB:
undetectable		 2zlcA-5oarB:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocy ACPA E4 FAB FRAGMENT
- HEAVY CHAIN

(Homo sapiens) 		no annotation 4 LEU H  81
ILE H  99
TRP H 110
TYR H  60
 None
 1.32A 2zlcA-5ocyH:
undetectable		 2zlcA-5ocyH:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 4 LEU B 684
ILE B 320
ARG B 248
TYR B 625
 None
 1.34A 2zlcA-5swiB:
undetectable		 2zlcA-5swiB:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ts5 AMINE OXIDASE

(Bothrops atrox) 		PF01593
(Amino_oxidase) 		4 LEU A  91
ILE A 430
ARG A 322
TRP A 420
 None
FAD  A 501 (-4.6A)
None
FAD  A 501 (-4.3A)
 1.43A 2zlcA-5ts5A:
undetectable		 2zlcA-5ts5A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ueb NEGOA.19184.A

(Neisseria
gonorrhoeae) 		PF14085
(DUF4265) 		4 LEU A  84
ILE A  36
ARG A  96
TYR A 112
 None
 1.21A 2zlcA-5uebA:
undetectable		 2zlcA-5uebA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au1 PUTATIVE HEMIN
STORAGE PROTEIN

(Bordetella
bronchiseptica) 		no annotation 4 LEU A 630
ARG A 595
TRP A 593
TYR A 645
 None
SO4  A 703 (-3.9A)
None
None
 1.22A 2zlcA-6au1A:
undetectable		 2zlcA-6au1A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bf4 VRC-PG05 FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 4 LEU B  80
ILE B  95
TRP B 103
TYR B  59
 None
 1.32A 2zlcA-6bf4B:
undetectable		 2zlcA-6bf4B:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbr -

(-) 		no annotation 4 LEU A 816
ILE A 968
ARG A 971
TYR A 957
 None
 1.40A 2zlcA-6dbrA:
undetectable		 2zlcA-6dbrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 896
ILE A1371
ARG A 888
TYR A1364
 None
 1.23A 2zlcA-6f42A:
undetectable		 2zlcA-6f42A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 5 LEU A 255
ILE A 299
ARG A 302
TRP A 314
TYR A 427
 None
DZW  A 501 (-4.7A)
DZW  A 501 (-3.8A)
DZW  A 501 (-3.5A)
DZW  A 501 (-4.9A)
 0.19A 2zlcA-6fobA:
38.9		 2zlcA-6fobA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fzw COLLAGEN
ALPHA-1(III) CHAIN

(Homo sapiens) 		no annotation 4 LEU A  87
ILE A 223
TRP A  94
TYR A 119
 None
 1.28A 2zlcA-6fzwA:
undetectable		 2zlcA-6fzwA:
20.71