SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZLC_A_VDXA500

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE

(Pseudomonas
putida) 		PF00221
(Lyase_aromatic) 		5 LEU A 146
SER A 143
SER A 410
LEU A  75
LEU A 185
 None
SO4  A1511 (-3.2A)
None
None
None
 1.09A 2zlcA-1gk2A:
0.0		 2zlcA-1gk2A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnz GSI-B4 ISOLECTIN

(Griffonia
simplicifolia) 		PF00139
(Lectin_legB) 		5 LEU A 110
SER A 217
VAL A 149
LEU A 184
LEU A  60
 None
 1.37A 2zlcA-1gnzA:
undetectable		 2zlcA-1gnzA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihp PHYTASE

(Aspergillus
ficuum) 		PF00328
(His_Phos_2) 		5 LEU A 113
SER A 116
SER A 382
VAL A 143
LEU A 187
 None
 1.07A 2zlcA-1ihpA:
0.0		 2zlcA-1ihpA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA

(Treponema
pallidum) 		PF01297
(ZnuA) 		5 SER A 206
VAL A 219
HIS A  68
LEU A  93
LEU A  69
 None
 1.36A 2zlcA-1k0fA:
0.0		 2zlcA-1k0fA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		5 LEU A 522
VAL A 518
VAL A 204
LEU A 273
LEU A 461
 None
 1.29A 2zlcA-1lnsA:
0.0		 2zlcA-1lnsA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n4o L2 BETA-LACTAMASE

(Stenotrophomonas
maltophilia) 		PF13354
(Beta-lactamase2) 		5 LEU A 190
SER A  74
SER A 160
LEU A 279
LEU A 225
 None
 1.37A 2zlcA-1n4oA:
0.0		 2zlcA-1n4oA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nf3 PAR-6B

(Mus musculus) 		PF00595
(PDZ) 		5 LEU C 216
VAL C 246
SER C 178
VAL C 231
LEU C 242
 LEU  C 216 ( 0.6A)
VAL  C 246 ( 0.6A)
SER  C 178 ( 0.0A)
VAL  C 231 ( 0.6A)
LEU  C 242 ( 0.6A)
 1.32A 2zlcA-1nf3C:
undetectable		 2zlcA-1nf3C:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nso PROTEASE

(Mason-Pfizer
monkey virus) 		PF00077
(RVP) 		5 LEU A  36
VAL A  84
SER A  64
LEU A  16
LEU A  24
 None
 1.42A 2zlcA-1nsoA:
undetectable		 2zlcA-1nsoA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 TYR A 176
VAL A 118
VAL A 123
LEU A  95
LEU A  92
 None
 1.19A 2zlcA-1nxkA:
0.0		 2zlcA-1nxkA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5m PROSTAGLANDIN-E2
9-REDUCTASE

(Oryctolagus
cuniculus) 		PF00248
(Aldo_ket_red) 		5 LEU A 268
SER A 166
HIS A 194
LEU A 197
LEU A 235
 NDP  A1003 (-4.1A)
NDP  A1003 (-2.8A)
None
None
None
 1.36A 2zlcA-1q5mA:
undetectable		 2zlcA-1q5mA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuu ACETATE KINASE

(Methanosarcina
thermophila) 		PF00871
(Acetate_kinase) 		5 VAL A 218
SER A 223
SER A 227
VAL A 326
LEU A 195
 None
 1.39A 2zlcA-1tuuA:
undetectable		 2zlcA-1tuuA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u08 HYPOTHETICAL
AMINOTRANSFERASE
YBDL

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 LEU A 219
VAL A 218
SER A 217
SER A 232
LEU A 166
 None
 1.33A 2zlcA-1u08A:
undetectable		 2zlcA-1u08A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2z HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Saccharomyces
cerevisiae) 		PF08123
(DOT1) 		5 TYR A 372
LEU A 376
VAL A 541
SER A 542
VAL A 383
 None
 1.41A 2zlcA-1u2zA:
undetectable		 2zlcA-1u2zA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukw ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 388
SER A 188
SER A 237
VAL A 276
LEU A 269
 FAD  A 420 (-4.2A)
FAD  A 420 (-3.0A)
None
None
None
 1.32A 2zlcA-1ukwA:
1.6		 2zlcA-1ukwA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x7p RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00588
(SpoU_methylase) 		5 LEU A 177
VAL A 170
SER A 173
VAL A 110
LEU A  28
 None
 1.38A 2zlcA-1x7pA:
undetectable		 2zlcA-1x7pA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ya0 SMG-7 TRANSCRIPT
VARIANT 2

(Homo sapiens) 		PF10373
(EST1_DNA_bind)
PF10374
(EST1) 		5 LEU A 302
SER A 430
VAL A 295
HIS A 296
LEU A 203
 None
 1.16A 2zlcA-1ya0A:
undetectable		 2zlcA-1ya0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqd SINAPYL ALCOHOL
DEHYDROGENASE

(Populus
tremuloides) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 195
CYH A  50
HIS A 259
LEU A 284
LEU A 264
 NAP  A 500 (-3.4A)
ZN  A1000 (-2.3A)
None
None
None
 1.34A 2zlcA-1yqdA:
undetectable		 2zlcA-1yqdA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b61 HOMOSERINE
O-ACETYLTRANSFERASE

(Haemophilus
influenzae) 		PF00561
(Abhydrolase_1) 		5 LEU A 273
SER A 168
SER A 169
VAL A 117
HIS A  47
 None
 1.21A 2zlcA-2b61A:
undetectable		 2zlcA-2b61A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4p HYPOTHETICAL PROTEIN
TM1010

(Thermotoga
maritima) 		PF07883
(Cupin_2) 		5 VAL A  23
SER A  10
SER A  13
HIS A  95
LEU A  60
 UNL  A 136 ( 4.9A)
None
None
UNL  A 136 (-3.9A)
None
 1.43A 2zlcA-2f4pA:
undetectable		 2zlcA-2f4pA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF01661
(Macro) 		5 LEU A  94
VAL A  96
SER A  81
VAL A 152
LEU A 127
 None
 1.32A 2zlcA-2favA:
undetectable		 2zlcA-2favA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E

(Pisum sativum) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		5 VAL A 110
SER A 113
SER A 141
VAL A 234
LEU A 219
 None
 1.13A 2zlcA-2h21A:
undetectable		 2zlcA-2h21A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipf (3(17)ALPHA-HYDROXYS
TEROID
DEHYDROGENASE)

(Mus musculus) 		PF00248
(Aldo_ket_red) 		5 LEU A 268
SER A 166
HIS A 194
LEU A 197
LEU A 235
 NAP  A   1 ( 4.3A)
NAP  A   1 (-3.0A)
None
None
None
 1.38A 2zlcA-2ipfA:
undetectable		 2zlcA-2ipfA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY

(Enterococcus
faecalis) 		PF04198
(Sugar-bind) 		5 LEU A 124
VAL A 123
SER A 117
SER A 242
VAL A 130
 None
None
None
PO4  A 401 ( 4.0A)
None
 1.40A 2zlcA-2o0mA:
undetectable		 2zlcA-2o0mA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1t ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90) 		5 LEU A 640
SER A 643
SER A 725
LEU A 627
LEU A 618
 None
 1.30A 2zlcA-2o1tA:
undetectable		 2zlcA-2o1tA:
22.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2o4j VITAMIN D3 RECEPTOR

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		5 LEU A 229
SER A 233
SER A 274
CYH A 284
LEU A 389
 VD4  A 500 ( 4.8A)
VD4  A 500 ( 2.8A)
VD4  A 500 ( 2.9A)
VD4  A 500 ( 3.4A)
None
 1.27A 2zlcA-2o4jA:
41.7		 2zlcA-2o4jA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2o4j VITAMIN D3 RECEPTOR

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		5 LEU A 229
SER A 271
SER A 274
HIS A 301
LEU A 220
 VD4  A 500 ( 4.8A)
VD4  A 500 ( 3.9A)
VD4  A 500 ( 2.9A)
VD4  A 500 ( 3.9A)
None
 1.33A 2zlcA-2o4jA:
41.7		 2zlcA-2o4jA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2o4j VITAMIN D3 RECEPTOR

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		12 TYR A 143
LEU A 229
VAL A 230
SER A 233
SER A 271
SER A 274
CYH A 284
VAL A 296
HIS A 301
LEU A 305
HIS A 393
LEU A 400
 VD4  A 500 ( 4.7A)
VD4  A 500 ( 4.8A)
VD4  A 500 ( 4.6A)
VD4  A 500 ( 2.8A)
VD4  A 500 ( 3.9A)
VD4  A 500 ( 2.9A)
VD4  A 500 ( 3.4A)
VD4  A 500 ( 4.4A)
VD4  A 500 ( 3.9A)
None
VD4  A 500 ( 3.9A)
VD4  A 500 ( 4.9A)
 0.32A 2zlcA-2o4jA:
41.7		 2zlcA-2o4jA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qg7 ETHANOLAMINE KINASE
PV091845

(Plasmodium
vivax) 		PF01633
(Choline_kinase) 		5 LEU A 236
SER A 234
SER A 288
CYH A 283
LEU A 206
 None
 1.38A 2zlcA-2qg7A:
undetectable		 2zlcA-2qg7A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		5 LEU B 438
VAL B 437
SER B 360
VAL B 486
LEU B 480
 None
 1.24A 2zlcA-2uzxB:
undetectable		 2zlcA-2uzxB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpk MYONEURIN

(Homo sapiens) 		PF00651
(BTB) 		5 TYR A  53
LEU A 102
VAL A 104
SER A  46
LEU A  87
 None
 1.14A 2zlcA-2vpkA:
undetectable		 2zlcA-2vpkA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjs LAMININ SUBUNIT
ALPHA-2

(Mus musculus) 		PF00054
(Laminin_G_1) 		5 LEU A2423
VAL A2360
SER A2358
LEU A2372
LEU A2492
 None
 1.25A 2zlcA-2wjsA:
undetectable		 2zlcA-2wjsA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zk7 GLUCOSE
1-DEHYDROGENASE
RELATED PROTEIN

(Thermoplasma
acidophilum) 		PF13561
(adh_short_C2) 		5 TYR A 108
VAL A 146
SER A 148
SER A 131
LEU A 245
 None
 1.38A 2zlcA-2zk7A:
undetectable		 2zlcA-2zk7A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 SER A 272
SER A 231
SER A 198
HIS A 136
HIS A 134
 None
None
None
CU  A 701 (-3.2A)
CU  A 702 (-3.1A)
 1.26A 2zlcA-3abgA:
undetectable		 2zlcA-3abgA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Sulfolobus
shibatae) 		PF01070
(FMN_dh) 		5 VAL A 265
SER A 264
SER A 200
VAL A 192
LEU A 176
 None
 1.23A 2zlcA-3b05A:
undetectable		 2zlcA-3b05A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6n ASPARTATE
CARBAMOYLTRANSFERASE

(Aquifex
aeolicus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU B   4
VAL B 117
SER B 163
VAL B 281
LEU B  59
 None
 1.12A 2zlcA-3d6nB:
undetectable		 2zlcA-3d6nB:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0j DNA POLYMERASE
SUBUNIT DELTA-2
DNA POLYMERASE
SUBUNIT DELTA-3

(Homo sapiens) 		PF04042
(DNA_pol_E_B)
PF09507
(CDC27) 		5 VAL A  27
SER B 130
VAL A 241
LEU A 439
LEU A 442
 None
 1.12A 2zlcA-3e0jA:
undetectable		 2zlcA-3e0jA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fed GLUTAMATE
CARBOXYPEPTIDASE III

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 TYR A 575
LEU A 463
SER A 580
HIS A 637
LEU A 640
 None
 1.22A 2zlcA-3fedA:
undetectable		 2zlcA-3fedA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6z POLYCOMB PROTEIN
SFMBT

(Drosophila
melanogaster) 		PF02820
(MBT) 		5 LEU A 693
SER A 734
CYH A 730
VAL A 704
LEU A 757
 None
 1.28A 2zlcA-3h6zA:
undetectable		 2zlcA-3h6zA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipl 2-SUCCINYLBENZOATE--
COA LIGASE

(Staphylococcus
aureus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 278
SER A 302
SER A 215
SER A 218
LEU A 268
 None
 1.40A 2zlcA-3iplA:
undetectable		 2zlcA-3iplA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF17

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		5 LEU L 273
SER L 329
SER L 330
LEU L 306
LEU L 302
 None
 1.28A 2zlcA-3jb9L:
undetectable		 2zlcA-3jb9L:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khe CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF13499
(EF-hand_7) 		5 VAL A  96
SER A  95
SER A  18
LEU A 119
LEU A  42
 None
 1.39A 2zlcA-3kheA:
undetectable		 2zlcA-3kheA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Ruegeria
pomeroyi) 		PF00356
(LacI)
PF00532
(Peripla_BP_1) 		5 LEU A  97
VAL A  69
SER A 124
VAL A  91
LEU A  85
 None
 1.25A 2zlcA-3kjxA:
undetectable		 2zlcA-3kjxA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln3 DIHYDRODIOL
DEHYDROGENASE

(Mus musculus) 		PF00248
(Aldo_ket_red) 		5 LEU A 268
SER A 166
HIS A 194
LEU A 197
LEU A 235
 NAD  A 327 ( 4.4A)
NAD  A 327 (-2.8A)
None
None
None
 1.33A 2zlcA-3ln3A:
undetectable		 2zlcA-3ln3A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of7 REGULATOR OF
CHROMOSOME
CONDENSATION

(Saccharomyces
cerevisiae) 		PF00415
(RCC1)
PF13540
(RCC1_2) 		5 LEU A 324
VAL A 296
SER A 342
CYH A 354
VAL A 318
 None
 1.21A 2zlcA-3of7A:
undetectable		 2zlcA-3of7A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ovg AMIDOHYDROLASE

(Mycoplasma
synoviae) 		PF02126
(PTE) 		5 VAL A 185
SER A  96
VAL A 171
LEU A 112
LEU A 166
 None
KCX  A 153 ( 3.4A)
None
None
None
 1.31A 2zlcA-3ovgA:
undetectable		 2zlcA-3ovgA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		5 LEU B 285
SER B 289
VAL B 213
LEU B 253
LEU B 134
 None
 1.24A 2zlcA-3p8cB:
undetectable		 2zlcA-3p8cB:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxn KINESIN-LIKE PROTEIN
NOD

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		5 SER A 284
SER A 140
CYH A 169
LEU A 227
LEU A 251
 None
 1.39A 2zlcA-3pxnA:
undetectable		 2zlcA-3pxnA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmu METHYLMALONYL-COA
EPIMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF13669
(Glyoxalase_4) 		5 LEU A 170
VAL A 169
SER A 144
LEU A  45
LEU A  48
 None
None
None
EDO  A 177 ( 4.3A)
None
 1.26A 2zlcA-3rmuA:
undetectable		 2zlcA-3rmuA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tf7 42F3 MUT7 SCFV (42F3
ALPHA CHAIN, LINKER,
42F3 BETA CHAIN)

(Mus musculus) 		PF07686
(V-set) 		5 LEU C 233
SER C 227
SER C  99
SER C  93
LEU C 209
 None
None
GOL  C 254 ( 3.9A)
None
None
 1.41A 2zlcA-3tf7C:
undetectable		 2zlcA-3tf7C:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsr RIBONUCLEASE
INHIBITOR

(Mus musculus) 		PF13516
(LRR_6) 		5 LEU E 248
SER E 250
SER E 220
LEU E 229
LEU E 271
 None
 1.30A 2zlcA-3tsrE:
undetectable		 2zlcA-3tsrE:
20.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wgp VITAMIN D3 RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 TYR A 143
LEU A 233
VAL A 234
SER A 237
SER A 275
SER A 278
CYH A 288
VAL A 300
HIS A 305
LEU A 309
HIS A 397
LEU A 404
 ED9  A 501 (-3.7A)
ED9  A 501 ( 4.3A)
None
ED9  A 501 (-2.7A)
ED9  A 501 (-3.9A)
ED9  A 501 (-2.7A)
ED9  A 501 (-3.4A)
ED9  A 501 (-4.5A)
ED9  A 501 (-3.9A)
ED9  A 501 (-4.9A)
ED9  A 501 (-3.9A)
None
 0.25A 2zlcA-3wgpA:
38.7		 2zlcA-3wgpA:
90.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif HEXON PROTEIN

(Bovine
mastadenovirus
B) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 VAL A 716
SER A 719
CYH A 825
VAL A 728
LEU A 697
 None
 1.43A 2zlcA-3zifA:
undetectable		 2zlcA-3zifA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 VAL B3078
HIS B3075
LEU B3109
HIS B3106
LEU B3236
 None
CUO  B9008 (-2.8A)
None
CUO  B9008 (-3.3A)
None
 1.42A 2zlcA-4bedB:
undetectable		 2zlcA-4bedB:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF14574
(DUF4445) 		5 VAL I 538
SER I 568
SER I 573
VAL I 385
LEU I 525
 None
 1.42A 2zlcA-4c1nI:
undetectable		 2zlcA-4c1nI:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN

(Escherichia
coli) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 LEU A 187
VAL A 102
VAL A 208
HIS A 209
LEU A 240
 None
 1.43A 2zlcA-4c7oA:
undetectable		 2zlcA-4c7oA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 LEU A 393
SER A 404
VAL A 298
LEU A 307
LEU A 672
 None
NAG  A3570 (-4.7A)
None
None
None
 1.31A 2zlcA-4cakA:
undetectable		 2zlcA-4cakA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		no annotation 5 VAL A 225
SER A 198
SER A 159
CYH A 163
VAL A 246
 None
 1.34A 2zlcA-4czxA:
undetectable		 2zlcA-4czxA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica) 		PF00291
(PALP) 		5 LEU A 234
SER A 161
SER A 193
LEU A 206
LEU A   3
 None
LLP  A  51 ( 3.4A)
None
None
None
 1.43A 2zlcA-4d8uA:
undetectable		 2zlcA-4d8uA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dey VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-2

(Oryctolagus
cuniculus) 		PF00625
(Guanylate_kin)
PF12052
(VGCC_beta4Aa_N) 		5 VAL A 224
SER A 334
VAL A  96
HIS A  95
LEU A 314
 None
BR  A 512 (-4.6A)
None
None
None
 1.28A 2zlcA-4deyA:
undetectable		 2zlcA-4deyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Methanosarcina
mazei) 		PF01458
(UPF0051) 		5 LEU A  74
VAL A  73
SER A  79
SER A  51
HIS A 188
 None
 1.27A 2zlcA-4dn7A:
undetectable		 2zlcA-4dn7A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9o IMV MEMBRANE PROTEIN

(Vaccinia virus) 		PF00194
(Carb_anhydrase) 		5 LEU X 170
VAL X 181
SER X   6
VAL X 231
LEU X  21
 None
 1.39A 2zlcA-4e9oX:
undetectable		 2zlcA-4e9oX:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emi TODA

(Pseudomonas
putida) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 LEU A  46
VAL A 133
VAL A 158
LEU A 146
LEU A 165
 FAD  A 501 ( 3.9A)
None
None
None
None
 1.44A 2zlcA-4emiA:
undetectable		 2zlcA-4emiA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gud IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISH

(Vibrio cholerae) 		PF00117
(GATase) 		5 VAL A  18
SER A  17
VAL A 182
LEU A 136
LEU A  75
 None
 1.41A 2zlcA-4gudA:
undetectable		 2zlcA-4gudA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN

(Candida
albicans;
Escherichia
coli) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		5 LEU A 423
SER A 463
SER A 430
LEU A 644
LEU A 589
 None
 1.24A 2zlcA-4h1gA:
undetectable		 2zlcA-4h1gA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k30 N-ACETYLGLUTAMATE
SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF04768
(NAT) 		5 LEU A 394
VAL A 395
SER A 398
LEU A 430
LEU A 411
 None
 1.19A 2zlcA-4k30A:
undetectable		 2zlcA-4k30A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI) 		5 LEU B 438
VAL B 437
SER B 360
VAL B 486
LEU B 480
 None
 1.33A 2zlcA-4k3jB:
undetectable		 2zlcA-4k3jB:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		5 LEU A 182
SER A 144
VAL A  48
LEU A 193
LEU A 201
 None
 1.28A 2zlcA-4llsA:
undetectable		 2zlcA-4llsA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt1 DRUG EFFLUX PROTEIN

(Neisseria
gonorrhoeae) 		PF00873
(ACR_tran) 		5 LEU A 115
VAL A 114
VAL A 129
LEU A  92
LEU A  62
 None
 1.23A 2zlcA-4mt1A:
1.5		 2zlcA-4mt1A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 TYR B 326
LEU B 315
SER B 696
LEU B 308
LEU B 143
 None
 1.33A 2zlcA-4qj4B:
undetectable		 2zlcA-4qj4B:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuc ANKYRIN REPEAT AND
SOCS BOX PROTEIN 11

(Homo sapiens) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU A 150
VAL A 149
SER A 143
SER A 141
LEU A  78
 None
 1.25A 2zlcA-4uucA:
undetectable		 2zlcA-4uucA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		5 LEU A1397
VAL A1396
SER A1390
VAL A1412
LEU A1210
 None
 1.24A 2zlcA-4xqkA:
undetectable		 2zlcA-4xqkA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN

(Schizosaccharomyces
pombe) 		no annotation 5 LEU A 686
SER A 680
SER A 658
LEU A 674
HIS A 676
 None
 1.41A 2zlcA-4yhcA:
undetectable		 2zlcA-4yhcA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aor DOSAGE COMPENSATION
REGULATOR

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		5 LEU A 537
VAL A 506
CYH A 554
LEU A 498
LEU A 491
 None
 1.34A 2zlcA-5aorA:
undetectable		 2zlcA-5aorA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb2 PROTEIN SEY1

(Candida
albicans) 		PF05879
(RHD3) 		5 LEU A 153
VAL A 152
SER A 150
VAL A 202
LEU A 269
 None
 1.14A 2zlcA-5cb2A:
undetectable		 2zlcA-5cb2A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm5 MYOMESIN-1
OBSCURIN-LIKE-1

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set) 		5 LEU M 574
SER M 557
CYH M 559
LEU O 329
LEU O 249
 None
 1.38A 2zlcA-5fm5M:
undetectable		 2zlcA-5fm5M:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 LEU B1070
SER B1065
VAL B1114
LEU B1052
HIS B1040
 None
 1.43A 2zlcA-5hb4B:
undetectable		 2zlcA-5hb4B:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jx3 URACIL-DNA
GLYCOSYLASE

(Vaccinia virus) 		no annotation 5 LEU A 170
VAL A 152
HIS A 151
LEU A  57
HIS A 147
 None
 1.22A 2zlcA-5jx3A:
undetectable		 2zlcA-5jx3A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxd TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 8

(Mus musculus) 		PF05527
(DUF758) 		5 LEU A  51
VAL A  50
SER A  47
LEU A 132
LEU A 171
 6OU  A 201 (-4.4A)
None
6OU  A 201 (-3.5A)
None
6OU  A 201 (-4.9A)
 1.33A 2zlcA-5jxdA:
undetectable		 2zlcA-5jxdA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5keg DNA DC->DU-EDITING
ENZYME APOBEC-3A

(Homo sapiens) 		PF08210
(APOBEC_N) 		5 LEU A  78
VAL A  79
SER A  81
HIS A 119
LEU A 114
 None
 1.35A 2zlcA-5kegA:
undetectable		 2zlcA-5kegA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvm ADHESION G-PROTEIN
COUPLED RECEPTOR G1

(Mus musculus) 		PF01825
(GPS) 		5 LEU A 313
SER A 253
VAL A 262
HIS A 335
LEU A 344
 None
 1.37A 2zlcA-5kvmA:
undetectable		 2zlcA-5kvmA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m41 NIGRITOXINE

(Vibrio
nigripulchritudo) 		no annotation 5 LEU A 103
VAL A 206
VAL A 182
LEU A  32
LEU A 199
 None
 1.21A 2zlcA-5m41A:
undetectable		 2zlcA-5m41A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN

(Arabidopsis
thaliana) 		PF00421
(PSII) 		5 TYR C 297
LEU C  95
VAL C 185
VAL C 176
LEU C 202
 CLA  C 503 ( 4.7A)
CLA  C 503 (-4.1A)
None
None
None
 1.25A 2zlcA-5mdxC:
undetectable		 2zlcA-5mdxC:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me3 SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		5 TYR A1248
LEU A1241
VAL A1238
SER A1253
LEU A1198
 None
 1.41A 2zlcA-5me3A:
undetectable		 2zlcA-5me3A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s CELL DIVISION
CONTROL PROTEIN 45

(Saccharomyces
cerevisiae) 		PF02724
(CDC45) 		5 TYR E  64
LEU E  83
VAL E  84
SER E  32
LEU E 258
 None
 1.00A 2zlcA-5u8sE:
undetectable		 2zlcA-5u8sE:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uso PROTECTION OF
TELOMERES PROTEIN 1

(Schizosaccharomyces
pombe) 		no annotation 5 LEU A  35
VAL A  37
CYH A  79
VAL A  94
LEU A 104
 None
 1.43A 2zlcA-5usoA:
undetectable		 2zlcA-5usoA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v76 MICROCOMPARTMENTS
PROTEIN

(Haliangium
ochraceum) 		no annotation 5 LEU A  37
VAL A  36
SER A  35
SER A  24
LEU A  94
 None
 1.02A 2zlcA-5v76A:
undetectable		 2zlcA-5v76A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 336
VAL A 335
SER A 329
CYH A 301
LEU A 354
 None
 1.24A 2zlcA-5vcxA:
undetectable		 2zlcA-5vcxA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8g 2-SUCCINYLBENZOATE--
COA LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 261
SER A 285
SER A 198
SER A 201
LEU A 247
 S0N  A 501 (-4.3A)
S0N  A 501 ( 4.4A)
S0N  A 501 (-2.8A)
S0N  A 501 ( 4.0A)
None
 1.18A 2zlcA-5x8gA:
undetectable		 2zlcA-5x8gA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)

(Cryptosporidium
parvum) 		no annotation 5 TYR A 238
LEU A 501
VAL A 502
VAL A 507
LEU A 609
 None
 1.27A 2zlcA-5xioA:
undetectable		 2zlcA-5xioA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
RESPIRATORY COMPLEX
SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT

(Desulfovibrio
gigas) 		no annotation 5 LEU B 224
CYH B 151
VAL B 217
HIS C 106
LEU C 104
 SF4  B 302 (-4.7A)
SF4  B 302 (-2.2A)
None
None
None
 1.20A 2zlcA-5xmjB:
undetectable		 2zlcA-5xmjB:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnz CRED

(Streptomyces
cremeus) 		no annotation 5 LEU A 434
VAL A 381
SER A 380
VAL A 425
LEU A 419
 None
 1.41A 2zlcA-5xnzA:
undetectable		 2zlcA-5xnzA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xww AMPHB

(Streptomyces
nodosus) 		no annotation 5 LEU A 222
VAL A 302
CYH A 278
LEU A 377
LEU A 386
 None
 1.44A 2zlcA-5xwwA:
undetectable		 2zlcA-5xwwA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0c NEROL DEHYDROGENASE

(Persicaria
minor) 		no annotation 5 LEU A 196
SER A  53
CYH A  51
HIS A 260
LEU A 265
 BME  A 405 (-3.9A)
ZN  A 402 ( 3.9A)
ZN  A 402 (-2.3A)
None
None
 1.14A 2zlcA-5z0cA:
undetectable		 2zlcA-5z0cA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0c NEROL DEHYDROGENASE

(Persicaria
minor) 		no annotation 5 VAL A 278
SER A  53
CYH A  51
HIS A 260
LEU A 265
 None
ZN  A 402 ( 3.9A)
ZN  A 402 (-2.3A)
None
None
 1.28A 2zlcA-5z0cA:
undetectable		 2zlcA-5z0cA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei9 TRNA-DIHYDROURIDINE
SYNTHASE B

(Escherichia
coli) 		no annotation 5 LEU A 287
HIS A 262
LEU A 266
HIS A 282
LEU A  28
 None
 1.28A 2zlcA-6ei9A:
undetectable		 2zlcA-6ei9A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 5 LEU A 261
SER A 265
SER A 306
CYH A 316
LEU A 419
 DZW  A 501 ( 4.5A)
DZW  A 501 (-3.0A)
DZW  A 501 (-2.7A)
DZW  A 501 (-3.4A)
None
 1.31A 2zlcA-6fobA:
38.9		 2zlcA-6fobA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 5 LEU A 261
VAL A 262
SER A 303
LEU A 338
HIS A 333
 DZW  A 501 ( 4.5A)
None
DZW  A 501 (-3.8A)
None
DZW  A 501 (-3.9A)
 1.33A 2zlcA-6fobA:
38.9		 2zlcA-6fobA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 6 TYR A 175
LEU A 261
VAL A 262
SER A 265
SER A 303
LEU A 338
 None
DZW  A 501 ( 4.5A)
None
DZW  A 501 (-3.0A)
DZW  A 501 (-3.8A)
None
 1.26A 2zlcA-6fobA:
38.9		 2zlcA-6fobA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 12 TYR A 175
LEU A 261
VAL A 262
SER A 265
SER A 303
SER A 306
CYH A 316
VAL A 328
HIS A 333
LEU A 337
HIS A 423
LEU A 430
 None
DZW  A 501 ( 4.5A)
None
DZW  A 501 (-3.0A)
DZW  A 501 (-3.8A)
DZW  A 501 (-2.7A)
DZW  A 501 (-3.4A)
DZW  A 501 ( 4.3A)
DZW  A 501 (-3.9A)
None
DZW  A 501 (-4.0A)
None
 0.34A 2zlcA-6fobA:
38.9		 2zlcA-6fobA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 5 SER A 238
VAL A 244
LEU A  43
HIS A 160
LEU A  50
 None
ACR  A 602 (-4.3A)
ACR  A 602 ( 4.7A)
None
None
 1.38A 2zlcA-6gneA:
undetectable		 2zlcA-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ejb LUMAZINE SYNTHASE

(Saccharomyces
cerevisiae) 		PF00885
(DMRL_synthase) 		4 LEU A 109
ILE A  31
ARG A  28
TRP A  26
 None
None
None
INJ  A 200 (-3.9A)
 1.43A 2zlcA-1ejbA:
undetectable		 2zlcA-1ejbA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8r L-AMINO ACID OXIDASE

(Calloselasma
rhodostoma) 		PF01593
(Amino_oxidase) 		4 LEU A  91
ILE A 430
ARG A 322
TRP A 420
 None
FAD  A 527 (-4.7A)
CIT  A 526 (-3.3A)
FAD  A 527 (-3.8A)
 1.45A 2zlcA-1f8rA:
0.0		 2zlcA-1f8rA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		4 LEU A 321
ILE A 240
ARG A 405
TYR A 416
 None
 1.45A 2zlcA-1hg4A:
19.1		 2zlcA-1hg4A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jiu DNA
BETA-GLUCOSYLTRANSFE
RASE

(Escherichia
virus T4) 		PF09198
(T4-Gluco-transf) 		4 LEU A 324
ILE A 255
ARG A 269
TRP A 271
 None
None
UDP  A 353 (-3.9A)
None
 1.12A 2zlcA-1jiuA:
0.0		 2zlcA-1jiuA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE

(Thermococcus
litoralis) 		PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926) 		4 LEU A 134
ILE A 177
ARG A 182
TYR A 141
 None
 1.43A 2zlcA-1k1xA:
0.0		 2zlcA-1k1xA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcj NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		4 LEU A 266
ILE A 262
ARG A 257
TYR A 214
 None
 1.50A 2zlcA-1vcjA:
0.0		 2zlcA-1vcjA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3n ALGQ1

(Sphingomonas
sp. A1) 		PF01547
(SBP_bac_1) 		4 LEU A 160
ILE A 184
ARG A 250
TYR A 139
 None
 1.27A 2zlcA-1y3nA:
0.0		 2zlcA-1y3nA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		4 LEU A 277
ILE A 125
ARG A 111
TYR A 122
 None
 1.41A 2zlcA-1z26A:
undetectable		 2zlcA-1z26A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adf 82D6A3 IGG

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 124
ILE L 149
ARG L 154
TRP L 147
 None
 1.17A 2zlcA-2adfL:
undetectable		 2zlcA-2adfL:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqx PREDICTED: INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE B

(Mus musculus) 		PF03770
(IPK) 		4 LEU A 704
ILE A 929
ARG A 851
TYR A 921
 None
 1.24A 2zlcA-2aqxA:
0.0		 2zlcA-2aqxA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ct8 METHIONYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 LEU A 475
ILE A 402
ARG A 324
TYR A  37
 None
 1.43A 2zlcA-2ct8A:
undetectable		 2zlcA-2ct8A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1n PEX

(Synechococcus
elongatus) 		PF03551
(PadR) 		4 LEU A  81
ILE A  93
ARG A 120
TYR A 111
 None
 1.20A 2zlcA-2e1nA:
undetectable		 2zlcA-2e1nA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6h MYOSIN-2

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		4 LEU X 180
ILE X 228
TRP X 293
TYR X 259
 None
 1.28A 2zlcA-2f6hX:
undetectable		 2zlcA-2f6hX:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu4 DIHYDROXYACETONE
KINASE

(Lactococcus
lactis) 		PF02733
(Dak1) 		4 LEU A 108
ILE A  88
ARG A  89
TYR A 127
 None
 1.26A 2zlcA-2iu4A:
undetectable		 2zlcA-2iu4A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2llz UNCHARACTERIZED
PROTEIN YJDK

(Escherichia
coli) 		PF11080
(GhoS) 		4 LEU A  52
ILE A  72
ARG A  73
TYR A  34
 None
 1.27A 2zlcA-2llzA:
undetectable		 2zlcA-2llzA:
22.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2o4j VITAMIN D3 RECEPTOR

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		5 LEU A 223
ILE A 267
ARG A 270
TRP A 282
TYR A 397
 None
VD4  A 500 ( 4.7A)
VD4  A 500 ( 4.0A)
VD4  A 500 ( 3.7A)
None
 0.13A 2zlcA-2o4jA:
41.7		 2zlcA-2o4jA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oh1 ACETYLTRANSFERASE,
GNAT FAMILY

(Listeria
monocytogenes) 		no annotation 4 LEU A 150
ILE A 139
TRP A  94
TYR A 157
 None
None
None
EDO  A 181 (-4.7A)
 1.40A 2zlcA-2oh1A:
undetectable		 2zlcA-2oh1A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plc PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C

(Listeria
monocytogenes) 		PF00388
(PI-PLC-X) 		4 LEU A 102
ILE A 121
ARG A  79
TYR A 146
 None
 1.37A 2zlcA-2plcA:
undetectable		 2zlcA-2plcA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnd V-SET AND
IMMUNOGLOBULIN
DOMAIN CONTAINING 4

(Mus musculus) 		PF07686
(V-set) 		4 LEU A  84
ILE A  58
ARG A  64
TYR A  92
 None
 1.30A 2zlcA-2pndA:
undetectable		 2zlcA-2pndA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2py6 METHYLTRANSFERASE
FKBM

(Methylobacillus
flagellatus) 		PF05050
(Methyltransf_21) 		4 LEU A 116
ILE A  98
ARG A 102
TYR A  92
 None
 1.44A 2zlcA-2py6A:
undetectable		 2zlcA-2py6A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vak SIGMA A

(Avian
orthoreovirus) 		PF03084
(Sigma_1_2) 		4 LEU A  28
ILE A 318
TRP A 132
TYR A  75
 None
 1.36A 2zlcA-2vakA:
undetectable		 2zlcA-2vakA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsa MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		4 LEU A  55
ILE A 681
ARG A 683
TYR A 718
 None
 1.47A 2zlcA-2vsaA:
undetectable		 2zlcA-2vsaA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1m METHIONYL-TRNA
SYNTHETASE

(Mycolicibacterium
smegmatis) 		PF09334
(tRNA-synt_1g) 		4 LEU A 168
ILE A 107
ARG A 110
TRP A 108
 None
 1.47A 2zlcA-2x1mA:
undetectable		 2zlcA-2x1mA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 LEU A  74
ILE A  62
TRP A  41
TYR A  89
 None
 1.06A 2zlcA-2x3kA:
undetectable		 2zlcA-2x3kA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		4 LEU A 393
ILE A 439
ARG A 435
TRP A 437
 None
 1.35A 2zlcA-3ayfA:
undetectable		 2zlcA-3ayfA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8b CYSQ, SULFITE
SYNTHESIS PATHWAY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00459
(Inositol_P) 		4 LEU A 139
ILE A  47
TRP A  78
TYR A 114
 None
 1.36A 2zlcA-3b8bA:
undetectable		 2zlcA-3b8bA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3u PEPTIDE DEFORMYLASE

(Mycobacterium
tuberculosis) 		PF01327
(Pep_deformylase) 		4 ILE A  57
ARG A   7
TRP A 186
TYR A  41
 NVC  A 202 (-4.8A)
None
None
None
 1.47A 2zlcA-3e3uA:
undetectable		 2zlcA-3e3uA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6m 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Yersinia pestis) 		PF02542
(YgbB) 		4 LEU A 156
ILE A 129
ARG A 115
TYR A  83
 None
 1.29A 2zlcA-3f6mA:
undetectable		 2zlcA-3f6mA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5w MULTICOPPER OXIDASE
TYPE 1

(Nitrosomonas
europaea) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A  50
ILE A 183
ARG A 234
TRP A 144
 None
 1.29A 2zlcA-3g5wA:
undetectable		 2zlcA-3g5wA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipl 2-SUCCINYLBENZOATE--
COA LIGASE

(Staphylococcus
aureus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 101
ILE A 232
ARG A 231
TYR A 212
 None
 1.10A 2zlcA-3iplA:
undetectable		 2zlcA-3iplA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtz INTEGRASE

(Yersinia pestis) 		PF13356
(Arm-DNA-bind_3) 		4 LEU A  53
ILE A   8
ARG A   9
TYR A  27
 None
 1.46A 2zlcA-3jtzA:
undetectable		 2zlcA-3jtzA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll7 PUTATIVE
METHYLTRANSFERASE

(Porphyromonas
gingivalis) 		no annotation 4 LEU A  47
ILE A  33
ARG A  38
TYR A  65
 None
 1.42A 2zlcA-3ll7A:
undetectable		 2zlcA-3ll7A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(marine
actinobacterium
PHSC20C1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 328
ILE A 157
ARG A 344
TRP A 349
 None
 1.13A 2zlcA-3msyA:
undetectable		 2zlcA-3msyA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx3 SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		4 LEU A 505
ILE A 420
TRP A 360
TYR A 443
 None
 1.24A 2zlcA-3mx3A:
undetectable		 2zlcA-3mx3A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nad FERULATE
DECARBOXYLASE

(Bacillus
pumilus) 		PF05870
(PA_decarbox) 		4 LEU A  72
ILE A 144
ARG A  44
TYR A  19
 None
 1.34A 2zlcA-3nadA:
undetectable		 2zlcA-3nadA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naw SECRETED EFFECTOR
PROTEIN

(Escherichia
coli) 		PF00805
(Pentapeptide)
PF13979
(SopA_C)
PF13981
(SopA) 		4 LEU A 689
ILE A 711
TRP A 658
TYR A 696
 None
 1.22A 2zlcA-3nawA:
undetectable		 2zlcA-3nawA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 LEU A  23
ILE A 499
ARG A  13
TRP A 504
 None
 1.48A 2zlcA-3ne5A:
1.1		 2zlcA-3ne5A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no6 TRANSCRIPTIONAL
ACTIVATOR TENA

(Staphylococcus
epidermidis) 		PF03070
(TENA_THI-4) 		4 LEU A  89
ILE A  18
ARG A 209
TYR A 167
 None
 1.47A 2zlcA-3no6A:
2.8		 2zlcA-3no6A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 316
ILE A 202
ARG A 204
TYR A 333
 None
None
SEP  A 241 ( 3.4A)
None
 1.48A 2zlcA-3nuuA:
undetectable		 2zlcA-3nuuA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5p TAXADIENE SYNTHASE

(Taxus
brevifolia) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 LEU A 755
ILE A 700
TRP A 694
TYR A 778
 None
 1.36A 2zlcA-3p5pA:
1.6		 2zlcA-3p5pA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6g HEAVY CHAIN OF FAB
OF RHESUS MAB 2.5B

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H  80
ILE H  95
TRP H 103
TYR H  59
 None
 1.31A 2zlcA-3q6gH:
undetectable		 2zlcA-3q6gH:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t12 GLIDING PROTEIN MGLB

(Thermus
thermophilus) 		PF03259
(Robl_LC7) 		4 LEU B 115
ARG B  25
TRP B  49
TYR B  95
 None
 1.37A 2zlcA-3t12B:
undetectable		 2zlcA-3t12B:
18.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wgp VITAMIN D3 RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 227
ILE A 271
ARG A 274
TRP A 286
TYR A 401
 None
ED9  A 501 (-4.5A)
ED9  A 501 (-2.9A)
ED9  A 501 (-3.5A)
None
 0.36A 2zlcA-3wgpA:
38.7		 2zlcA-3wgpA:
90.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 LEU B1302
ILE B1020
TRP B1526
TYR B1026
 None
 1.43A 2zlcA-3zefB:
undetectable		 2zlcA-3zefB:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhe PROTEIN SMG-7

(Caenorhabditis
elegans) 		PF10373
(EST1_DNA_bind) 		4 LEU B  82
ILE B 159
ARG B 126
TYR B 152
 None
 1.49A 2zlcA-3zheB:
undetectable		 2zlcA-3zheB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aej COLLAGEN
ALPHA-1(III) CHAIN

(Homo sapiens) 		PF01410
(COLFI) 		4 LEU A  87
ILE A 223
TRP A  94
TYR A 119
 None
 1.26A 2zlcA-4aejA:
undetectable		 2zlcA-4aejA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoe ACETYLCHOLINE-BINDIN
G PROTEIN TYPE 2

(Biomphalaria
glabrata) 		PF02931
(Neur_chan_LBD) 		4 LEU A 155
ILE A  23
ARG A  63
TYR A 148
 None
 1.39A 2zlcA-4aoeA:
undetectable		 2zlcA-4aoeA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce7 UNSATURATED
3S-RHAMNOGLYCURONYL
HYDROLASE

(Nonlabens
ulvanivorans) 		PF07470
(Glyco_hydro_88) 		4 LEU A 231
ARG A 219
TRP A 146
TYR A  95
 None
 1.50A 2zlcA-4ce7A:
undetectable		 2zlcA-4ce7A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 LEU A 524
ILE A 632
ARG A 635
TYR A 610
 None
 1.47A 2zlcA-4iigA:
undetectable		 2zlcA-4iigA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Escherichia
coli) 		PF03331
(LpxC) 		4 LEU A  26
ILE A  89
ARG A   5
TYR A  39
 None
 1.28A 2zlcA-4isaA:
undetectable		 2zlcA-4isaA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzw GLUTATHIONE
S-TRANSFERASE

(Streptococcus
sanguinis) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 LEU A 221
ILE A 244
ARG A 247
TYR A 213
 None
 1.38A 2zlcA-4mzwA:
undetectable		 2zlcA-4mzwA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pb0 AB53 LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 125
ILE L 150
ARG L 155
TRP L 148
 None
 1.46A 2zlcA-4pb0L:
undetectable		 2zlcA-4pb0L:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmu ENDO-1,4-BETA-XYLANA
SE A

(Xanthomonas
citri) 		PF00331
(Glyco_hydro_10) 		4 LEU A 195
ILE A 156
ARG A 164
TRP A 168
 None
 1.41A 2zlcA-4pmuA:
undetectable		 2zlcA-4pmuA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pua GLUTATHIONE
S-TRANSFERASE

(Streptococcus
pneumoniae) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 LEU A 222
ILE A 245
ARG A 248
TYR A 214
 None
 1.37A 2zlcA-4puaA:
undetectable		 2zlcA-4puaA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb9 ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycolicibacterium
smegmatis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 LEU A 254
ILE A 174
ARG A 177
TRP A 178
 None
 1.24A 2zlcA-4qb9A:
undetectable		 2zlcA-4qb9A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh0 SPORE PHOTOPRODUCT
LYASE

(Geobacillus
thermodenitrificans) 		no annotation 4 LEU A 320
ILE A 196
ARG A 215
TYR A 327
 None
 1.46A 2zlcA-4rh0A:
undetectable		 2zlcA-4rh0A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 LEU A2504
ILE A2466
TRP A2460
TYR A2442
 None
 1.49A 2zlcA-4rh7A:
undetectable		 2zlcA-4rh7A:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3k SPORE GERMINATION
PROTEIN YAAH

(Bacillus
megaterium) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		4 LEU A 323
ILE A 318
ARG A 402
TYR A 283
 None
None
SO4  A 501 (-2.9A)
None
 1.40A 2zlcA-4s3kA:
undetectable		 2zlcA-4s3kA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmu RECQ

(Cronobacter
sakazakii) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		4 LEU A  85
ILE A 121
ARG A 125
TYR A  57
 None
 1.20A 2zlcA-4tmuA:
undetectable		 2zlcA-4tmuA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upk PHOSPHONATE
MONOESTER HYDROLASE

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		4 LEU A 193
ILE A 313
ARG A 346
TYR A 210
 None
 1.48A 2zlcA-4upkA:
undetectable		 2zlcA-4upkA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 LEU A 806
ILE A 839
ARG A 860
TRP A 858
 None
 1.21A 2zlcA-4xriA:
undetectable		 2zlcA-4xriA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y05 KINESIN-LIKE PROTEIN
KIF2C

(Homo sapiens) 		PF00225
(Kinesin) 		4 LEU A 493
ILE A 259
ARG A 258
TYR A 581
 None
 1.25A 2zlcA-4y05A:
undetectable		 2zlcA-4y05A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ziu UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF07678
(A2M_comp) 		4 LEU A1569
ILE A1511
ARG A1509
TRP A1533
 None
 1.43A 2zlcA-4ziuA:
undetectable		 2zlcA-4ziuA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		4 LEU A1569
ILE A1511
ARG A1509
TRP A1533
 None
 1.50A 2zlcA-5a42A:
undetectable		 2zlcA-5a42A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fpr DNA LIGASE

(Staphylococcus
aureus) 		PF01653
(DNA_ligase_aden) 		4 LEU A  82
ILE A 277
ARG A 270
TYR A 219
 None
 1.46A 2zlcA-5fprA:
undetectable		 2zlcA-5fprA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai TAIL FIBER PROTEIN

(Salmonella
virus P22) 		no annotation 4 LEU Y 145
ILE Y 181
ARG Y 266
TYR Y 151
 None
 1.35A 2zlcA-5gaiY:
undetectable		 2zlcA-5gaiY:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrp MARBERG VIRUS
MONOCLONAL ANTIBODY
MR78 FAB HEAVY CHAIN

(Homo sapiens) 		no annotation 4 LEU H  91
ILE H 109
TRP H 139
TYR H  70
 None
 1.25A 2zlcA-5jrpH:
undetectable		 2zlcA-5jrpH:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kol UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		PF02464
(CinA) 		4 LEU A  28
ILE A  17
ARG A 161
TYR A  60
 None
CL  A 201 (-4.6A)
None
None
 1.34A 2zlcA-5kolA:
undetectable		 2zlcA-5kolA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oar BETA-HEXOSAMINIDASE

(Aspergillus
oryzae) 		no annotation 4 LEU B 537
ILE B 264
ARG B 262
TYR B 184
 None
 1.39A 2zlcA-5oarB:
undetectable		 2zlcA-5oarB:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocy ACPA E4 FAB FRAGMENT
- HEAVY CHAIN

(Homo sapiens) 		no annotation 4 LEU H  81
ILE H  99
TRP H 110
TYR H  60
 None
 1.32A 2zlcA-5ocyH:
undetectable		 2zlcA-5ocyH:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 4 LEU B 684
ILE B 320
ARG B 248
TYR B 625
 None
 1.34A 2zlcA-5swiB:
undetectable		 2zlcA-5swiB:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ts5 AMINE OXIDASE

(Bothrops atrox) 		PF01593
(Amino_oxidase) 		4 LEU A  91
ILE A 430
ARG A 322
TRP A 420
 None
FAD  A 501 (-4.6A)
None
FAD  A 501 (-4.3A)
 1.43A 2zlcA-5ts5A:
undetectable		 2zlcA-5ts5A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ueb NEGOA.19184.A

(Neisseria
gonorrhoeae) 		PF14085
(DUF4265) 		4 LEU A  84
ILE A  36
ARG A  96
TYR A 112
 None
 1.21A 2zlcA-5uebA:
undetectable		 2zlcA-5uebA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au1 PUTATIVE HEMIN
STORAGE PROTEIN

(Bordetella
bronchiseptica) 		no annotation 4 LEU A 630
ARG A 595
TRP A 593
TYR A 645
 None
SO4  A 703 (-3.9A)
None
None
 1.22A 2zlcA-6au1A:
undetectable		 2zlcA-6au1A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bf4 VRC-PG05 FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 4 LEU B  80
ILE B  95
TRP B 103
TYR B  59
 None
 1.32A 2zlcA-6bf4B:
undetectable		 2zlcA-6bf4B:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbr -

(-) 		no annotation 4 LEU A 816
ILE A 968
ARG A 971
TYR A 957
 None
 1.40A 2zlcA-6dbrA:
undetectable		 2zlcA-6dbrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 896
ILE A1371
ARG A 888
TYR A1364
 None
 1.23A 2zlcA-6f42A:
undetectable		 2zlcA-6f42A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 5 LEU A 255
ILE A 299
ARG A 302
TRP A 314
TYR A 427
 None
DZW  A 501 (-4.7A)
DZW  A 501 (-3.8A)
DZW  A 501 (-3.5A)
DZW  A 501 (-4.9A)
 0.19A 2zlcA-6fobA:
38.9		 2zlcA-6fobA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fzw COLLAGEN
ALPHA-1(III) CHAIN

(Homo sapiens) 		no annotation 4 LEU A  87
ILE A 223
TRP A  94
TYR A 119
 None
 1.28A 2zlcA-6fzwA:
undetectable		 2zlcA-6fzwA:
20.71