SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZJ0_C_2FAC500_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN


(Equus caballus)
PF00626
(Gelsolin)
4 LEU A  71
GLN A  82
THR A  73
THR A 105
None
1.04A 2zj0C-1d0nA:
undetectable
2zj0C-1d0nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddk IMP-1 METALLO
BETA-LACTAMASE


(Pseudomonas
aeruginosa)
PF00753
(Lactamase_B)
4 GLN A 212
THR A 209
THR A 140
HIS A  77
None
None
None
ZN  A 500 (-3.4A)
1.13A 2zj0C-1ddkA:
2.7
2zj0C-1ddkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN


(Propionibacterium
freudenreichii)
PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
4 LEU A 668
GLN A 643
THR A 640
THR A 683
None
None
None
B12  A 800 ( 4.9A)
1.32A 2zj0C-1e1cA:
2.1
2zj0C-1e1cA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE


(Azotobacter
vinelandii)
PF03971
(IDH)
4 LEU A 671
GLN A 635
THR A 632
THR A 685
None
1.27A 2zj0C-1j1wA:
undetectable
2zj0C-1j1wA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxi PHOSPHOMETHYLPYRIMID
INE KINASE


(Salmonella
enterica)
PF08543
(Phos_pyr_kin)
4 LEU A 244
THR A 205
THR A 214
HIS A 261
None
1.36A 2zj0C-1jxiA:
4.9
2zj0C-1jxiA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
4 LEU A 549
GLN A 590
THR A 553
HIS A 545
None
None
None
FE2  A 840 (-3.3A)
1.31A 2zj0C-1loxA:
undetectable
2zj0C-1loxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qz9 KYNURENINASE

(Pseudomonas
fluorescens)
PF00266
(Aminotran_5)
4 LEU A 306
GLN A 300
THR A 301
THR A 379
None
1.23A 2zj0C-1qz9A:
3.5
2zj0C-1qz9A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE


(Fervidobacterium
pennivorans)
PF00082
(Peptidase_S8)
4 LEU A 577
GLN A 618
THR A 619
THR A 572
None
1.26A 2zj0C-1r6vA:
4.2
2zj0C-1r6vA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rgi GELSOLIN

(Equus caballus)
PF00626
(Gelsolin)
4 LEU G  71
GLN G  82
THR G  73
THR G 105
None
1.05A 2zj0C-1rgiG:
undetectable
2zj0C-1rgiG:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t44 CHIMERA OF GELSOLIN
DOMAIN 1 AND
C-TERMINAL DOMAIN OF
THYMOSIN BETA-4


(Homo sapiens;
Mus musculus)
PF00626
(Gelsolin)
PF01290
(Thymosin)
4 LEU G  71
GLN G  82
THR G  73
THR G 105
None
1.00A 2zj0C-1t44G:
undetectable
2zj0C-1t44G:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE


(Thermus
thermophilus)
PF08543
(Phos_pyr_kin)
4 LEU A 241
THR A 202
THR A 211
HIS A 256
None
1.34A 2zj0C-1ub0A:
2.7
2zj0C-1ub0A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE


(Ruminiclostridium
thermocellum)
PF00759
(Glyco_hydro_9)
PF02927
(CelD_N)
4 LEU A 476
THR A 788
THR A 474
HIS A 387
None
1.13A 2zj0C-1ut9A:
undetectable
2zj0C-1ut9A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwk PHOSPHOGLYCERATE
DEHYDROGENASE


(Pyrococcus
horikoshii)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
4 LEU A 107
THR A 276
THR A 198
HIS A 200
None
1.36A 2zj0C-1wwkA:
14.6
2zj0C-1wwkA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atm HYALURONOGLUCOSAMINI
DASE


(Vespula
vulgaris)
PF01630
(Glyco_hydro_56)
4 LEU A  91
GLN A  43
THR A 164
HIS A  83
None
1.38A 2zj0C-2atmA:
undetectable
2zj0C-2atmA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1


(Homo sapiens)
PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth)
4 LEU A  22
GLN A  64
THR A  65
THR A  27
None
1.25A 2zj0C-2c4kA:
2.4
2zj0C-2c4kA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ff6 GELSOLIN

(Homo sapiens)
PF00626
(Gelsolin)
4 LEU G  71
GLN G  82
THR G  73
THR G 105
None
0.99A 2zj0C-2ff6G:
undetectable
2zj0C-2ff6G:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT


(Stenotrophomonas
maltophilia)
PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4)
4 LEU A 925
GLN A 830
THR A 909
THR A 835
None
1.40A 2zj0C-2gahA:
undetectable
2zj0C-2gahA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbb TALIN-1

(Mus musculus)
no annotation 4 LEU A1741
GLN A1764
THR A1765
THR A1704
None
1.08A 2zj0C-2kbbA:
undetectable
2zj0C-2kbbA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN


(Porphyromonas
gingivalis)
PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C)
4 GLN A 333
THR A 107
THR A 383
HIS A 414
GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
1.04A 2zj0C-2nvvA:
undetectable
2zj0C-2nvvA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o26 MAST/STEM CELL
GROWTH FACTOR
RECEPTOR


(Mus musculus)
no annotation 4 GLN X 275
THR X 277
THR X 306
HIS X 222
None
1.25A 2zj0C-2o26X:
undetectable
2zj0C-2o26X:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN


(Bacteroides
thetaiotaomicron)
PF02384
(N6_Mtase)
PF12161
(HsdM_N)
4 LEU A  18
GLN A  25
THR A  21
THR A 115
None
1.24A 2zj0C-2okcA:
5.1
2zj0C-2okcA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wlv GAG POLYPROTEIN

(Human
immunodeficiency
virus 2)
PF00607
(Gag_p24)
4 LEU B  14
THR B  18
THR B  47
HIS B  11
None
1.17A 2zj0C-2wlvB:
undetectable
2zj0C-2wlvB:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtp GTPASE IMAP FAMILY
MEMBER 2


(Homo sapiens)
PF04548
(AIG1)
4 GLN A 121
THR A 119
THR A 146
HIS A 147
None
1.39A 2zj0C-2xtpA:
undetectable
2zj0C-2xtpA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN


(Escherichia
coli)
PF02384
(N6_Mtase)
PF12161
(HsdM_N)
4 LEU B 163
GLN B 166
THR B 358
HIS B 335
None
1.32A 2zj0C-2y7cB:
3.1
2zj0C-2y7cB:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yet GH61 ISOZYME A

(Thermoascus
aurantiacus)
PF03443
(Glyco_hydro_61)
4 LEU A  41
GLN A   5
THR A  36
HIS A  57
HIC  A   1 ( 4.9A)
None
None
None
1.34A 2zj0C-2yetA:
undetectable
2zj0C-2yetA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq3 DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1


(Saccharomyces
cerevisiae)
PF03556
(Cullin_binding)
PF14555
(UBA_4)
4 LEU A 116
GLN A 137
THR A 133
THR A 109
None
1.25A 2zj0C-3bq3A:
undetectable
2zj0C-3bq3A:
18.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ce6 ADENOSYLHOMOCYSTEINA
SE


(Mycobacterium
tuberculosis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 LEU A  68
GLN A  73
THR A  74
THR A 219
HIS A 363
None
ADN  A 500 (-3.6A)
ADN  A 500 (-4.5A)
NAD  A 550 ( 2.8A)
ADN  A 500 ( 3.7A)
0.19A 2zj0C-3ce6A:
66.1
2zj0C-3ce6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjp PREDICTED
AMIDOHYDROLASE,
DIHYDROOROTASE
FAMILY


(Clostridium
acetobutylicum)
PF04909
(Amidohydro_2)
4 LEU A  32
THR A  30
THR A  35
HIS A  38
None
1.30A 2zj0C-3cjpA:
undetectable
2zj0C-3cjpA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db2 PUTATIVE
NADPH-DEPENDENT
OXIDOREDUCTASE


(Desulfitobacterium
hafniense)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 LEU A 178
GLN A 217
THR A 232
HIS A 341
None
1.28A 2zj0C-3db2A:
7.7
2zj0C-3db2A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN


(Streptococcus
agalactiae)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
4 LEU A 946
GLN A1036
THR A1035
THR A 922
None
None
None
CL  A1223 (-4.3A)
1.35A 2zj0C-3fawA:
undetectable
2zj0C-3fawA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG


(Escherichia
coli)
PF01134
(GIDA)
PF13932
(GIDA_assoc)
4 LEU A  42
GLN A 122
THR A  36
THR A 110
None
1.36A 2zj0C-3g05A:
3.0
2zj0C-3g05A:
22.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g1u ADENOSYLHOMOCYSTEINA
SE


(Leishmania
major)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 LEU A  51
GLN A  56
THR A  57
THR A 156
HIS A 300
None
ADN  A 438 (-3.8A)
ADN  A 438 (-4.6A)
NAD  A 439 ( 3.0A)
ADN  A 438 ( 4.0A)
0.28A 2zj0C-3g1uA:
53.4
2zj0C-3g1uA:
54.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gem SHORT CHAIN
DEHYDROGENASE


(Pseudomonas
savastanoi)
PF13561
(adh_short_C2)
4 LEU A  78
GLN A  74
THR A  75
HIS A  83
None
1.32A 2zj0C-3gemA:
7.2
2zj0C-3gemA:
17.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glq ADENOSYLHOMOCYSTEINA
SE


(Burkholderia
pseudomallei)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 LEU A  61
GLN A  66
THR A  67
THR A 200
HIS A 344
None
RAB  A 602 (-3.9A)
RAB  A 602 (-4.5A)
NAD  A 601 ( 2.9A)
RAB  A 602 ( 3.5A)
0.17A 2zj0C-3glqA:
58.6
2zj0C-3glqA:
57.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwj ARYLPHORIN

(Antheraea
pernyi)
PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C)
4 LEU A 290
GLN A 404
THR A 405
THR A 161
None
1.07A 2zj0C-3gwjA:
undetectable
2zj0C-3gwjA:
21.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h9u ADENOSYLHOMOCYSTEINA
SE


(Trypanosoma
brucei)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 LEU A  51
GLN A  56
THR A  57
THR A 156
HIS A 300
None
ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
0.40A 2zj0C-3h9uA:
55.6
2zj0C-3h9uA:
56.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3


(Enterococcus
faecalis)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
4 LEU A 301
THR A  14
THR A 324
HIS A 178
None
CSO  A  13 ( 3.6A)
None
None
1.37A 2zj0C-3il4A:
undetectable
2zj0C-3il4A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM


(Homo sapiens)
PF00149
(Metallophos)
4 LEU A 274
GLN A 193
THR A 208
HIS A 271
None
1.36A 2zj0C-3ll8A:
undetectable
2zj0C-3ll8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm6 STAGE V SPORULATION
PROTEIN AD


(Bacillus
subtilis)
PF07451
(SpoVAD)
4 LEU A 264
GLN A 293
THR A 232
HIS A 258
None
1.24A 2zj0C-3lm6A:
undetectable
2zj0C-3lm6A:
22.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n58 ADENOSYLHOMOCYSTEINA
SE


(Brucella
abortus)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 LEU A  54
GLN A  59
THR A  60
THR A 193
HIS A 337
None
K  A   2 ( 3.3A)
ADN  A 500 (-4.6A)
NAD  A 550 ( 3.0A)
ADN  A 500 ( 3.6A)
0.26A 2zj0C-3n58A:
58.7
2zj0C-3n58A:
60.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE


(Escherichia
coli)
PF02784
(Orn_Arg_deC_N)
4 LEU A  89
GLN A 493
THR A 582
HIS A 369
None
1.35A 2zj0C-3nzqA:
undetectable
2zj0C-3nzqA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2


(Saccharomyces
cerevisiae)
PF10193
(Telomere_reg-2)
4 LEU A 544
THR A 508
THR A 650
HIS A 646
None
1.39A 2zj0C-3o4zA:
undetectable
2zj0C-3o4zA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6b DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1


(Saccharomyces
cerevisiae)
PF03556
(Cullin_binding)
4 LEU A 116
GLN A 137
THR A 133
THR A 109
None
1.32A 2zj0C-3o6bA:
undetectable
2zj0C-3o6bA:
16.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3one ADENOSYLHOMOCYSTEINA
SE


(Lupinus luteus)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 LEU A  61
GLN A  66
THR A  67
THR A 206
HIS A 350
None
ADE  A 506 (-3.8A)
ADE  A 506 (-4.5A)
NAD  A 501 (-2.8A)
None
0.76A 2zj0C-3oneA:
58.2
2zj0C-3oneA:
59.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE


(Lactobacillus
brevis)
PF00348
(polyprenyl_synt)
4 LEU A 321
GLN A 291
THR A 294
HIS A  -2
None
1.36A 2zj0C-3pkoA:
undetectable
2zj0C-3pkoA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr5 CARDIAC CA2+ RELEASE
CHANNEL


(Mus musculus)
PF08709
(Ins145_P3_rec)
4 GLN A  33
THR A  27
THR A 210
HIS A 193
None
1.11A 2zj0C-3qr5A:
undetectable
2zj0C-3qr5A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tu5 GELSOLIN,PROTEIN
CORDON-BLEU,THYMOSIN
BETA-4


(Homo sapiens;
Mus musculus)
PF00626
(Gelsolin)
4 LEU B  47
GLN B  58
THR B  49
THR B  81
None
0.99A 2zj0C-3tu5B:
undetectable
2zj0C-3tu5B:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmn DEXTRANASE

(Streptococcus
mutans)
PF13199
(Glyco_hydro_66)
4 LEU A 638
GLN A 602
THR A 603
THR A 635
None
1.03A 2zj0C-3vmnA:
2.5
2zj0C-3vmnA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkm PYRIDOXAL PHOSPHATE
PHOSPHATASE,
PHOSPHOGLYCOLATE
PHOSPHATASE,
PYRIDOXAL PHOSPHATE
PHOSPHATASE


(Mus musculus)
PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6)
4 LEU A 249
GLN A 277
THR A 263
HIS A 257
None
1.25A 2zj0C-4bkmA:
3.7
2zj0C-4bkmA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx0 PYRIDOXAL PHOSPHATE
PHOSPHATASE


(Mus musculus)
PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6)
4 LEU A 236
GLN A 264
THR A 250
HIS A 244
None
1.34A 2zj0C-4bx0A:
3.9
2zj0C-4bx0A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnk L-AMINO ACID OXIDASE

(Streptococcus
cristatus)
PF03486
(HI0933_like)
4 GLN A 156
THR A   6
THR A 348
HIS A 389
None
1.12A 2zj0C-4cnkA:
undetectable
2zj0C-4cnkA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czw PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2


(Neurospora
crassa)
PF00929
(RNase_T)
PF13423
(UCH_1)
4 LEU A 531
THR A 986
THR A 528
HIS A 525
None
None
None
ZN  A3094 (-3.1A)
1.26A 2zj0C-4czwA:
undetectable
2zj0C-4czwA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE


(Homo sapiens)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63)
4 LEU B1781
GLN B1766
THR B1765
THR B1756
None
1.18A 2zj0C-4f92B:
undetectable
2zj0C-4f92B:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU


(Yersinia
enterocolitica)
PF01408
(GFO_IDH_MocA)
4 LEU A 168
GLN A 331
THR A 179
HIS A 322
None
1.01A 2zj0C-4gmfA:
5.4
2zj0C-4gmfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h63 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17


(Schizosaccharomyces
pombe)
PF10156
(Med17)
4 LEU Q 347
GLN Q 263
THR Q 349
HIS Q 394
None
1.16A 2zj0C-4h63Q:
undetectable
2zj0C-4h63Q:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkt INOSITOL
2-DEHYDROGENASE


(Sinorhizobium
meliloti)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 LEU A 183
GLN A 216
THR A 217
THR A 147
None
1.35A 2zj0C-4hktA:
9.3
2zj0C-4hktA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htw GAG PROTEIN

(Simian
immunodeficiency
virus)
PF00607
(Gag_p24)
4 LEU A  14
THR A  18
THR A  47
HIS A  11
None
1.19A 2zj0C-4htwA:
undetectable
2zj0C-4htwA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2


(Homo sapiens)
PF00415
(RCC1)
4 LEU A 600
GLN A 625
THR A 621
THR A 647
None
None
None
SO4  A 802 (-3.5A)
1.06A 2zj0C-4l1mA:
undetectable
2zj0C-4l1mA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1


(Arabidopsis
thaliana)
PF01399
(PCI)
PF10602
(RPN7)
4 LEU A 228
GLN A 191
THR A 193
HIS A 330
None
1.30A 2zj0C-4lctA:
undetectable
2zj0C-4lctA:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)


(Bradyrhizobium
elkanii)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 LEU A  57
GLN A  62
THR A  63
THR A 198
HIS A 342
None
NH4  A 502 ( 3.1A)
ADN  A 501 (-4.5A)
NAD  A 503 ( 2.9A)
ADN  A 501 ( 3.7A)
0.24A 2zj0C-4lvcA:
59.2
2zj0C-4lvcA:
58.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maa PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN


(Pseudomonas
protegens)
PF13458
(Peripla_BP_6)
4 LEU A 292
GLN A 297
THR A 296
THR A 286
None
1.28A 2zj0C-4maaA:
5.7
2zj0C-4maaA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mca GLYCEROL
DEHYDROGENASE


(Serratia
plymuthica)
PF00465
(Fe-ADH)
4 LEU A 173
GLN A 282
THR A 279
THR A 295
None
1.35A 2zj0C-4mcaA:
2.4
2zj0C-4mcaA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli)
PF02395
(Peptidase_S6)
4 LEU A 388
GLN A 375
THR A 393
THR A 385
None
1.08A 2zj0C-4om9A:
undetectable
2zj0C-4om9A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pkh GELSOLIN,TROPOMODULI
N-1 CHIMERA


(Homo sapiens)
PF00626
(Gelsolin)
PF03250
(Tropomodulin)
4 LEU B  98
GLN B 109
THR B 100
THR B 132
None
1.02A 2zj0C-4pkhB:
undetectable
2zj0C-4pkhB:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pki GELSOLIN,TROPOMODULI
N-1 CHIMERA


(Homo sapiens)
PF00626
(Gelsolin)
4 LEU G  98
GLN G 109
THR G 100
THR G 132
None
1.03A 2zj0C-4pkiG:
undetectable
2zj0C-4pkiG:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE


(Chlamydia
trachomatis)
PF00595
(PDZ)
PF03572
(Peptidase_S41)
4 GLN A 477
THR A 478
THR A 483
HIS A 231
None
1.31A 2zj0C-4ql6A:
undetectable
2zj0C-4ql6A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlb PROBABLE GLYCOGEN
[STARCH] SYNTHASE


(Caenorhabditis
elegans)
PF05693
(Glycogen_syn)
4 LEU A 214
GLN A 153
THR A 218
HIS A 271
None
1.33A 2zj0C-4qlbA:
4.4
2zj0C-4qlbA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubq BETA-LACTAMASE

(Acinetobacter
baumannii)
no annotation 4 GLN A 213
THR A 210
THR A 141
HIS A  78
None
None
None
ZN  A 301 (-3.4A)
1.23A 2zj0C-4ubqA:
3.0
2zj0C-4ubqA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz8 NUCLEOPROTEIN

(Thiafora
orthonairovirus)
PF02477
(Nairo_nucleo)
4 LEU A 452
GLN A 159
THR A 472
THR A 413
None
1.22A 2zj0C-4xz8A:
undetectable
2zj0C-4xz8A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9v PARTICLE-ASSOCIATED
LYASE


(Acinetobacter
virus AP22)
no annotation 4 LEU A 501
THR A 497
THR A 540
HIS A 572
None
1.32A 2zj0C-4y9vA:
undetectable
2zj0C-4y9vA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylq COAGULATION FACTOR
VII


(Homo sapiens)
PF00089
(Trypsin)
4 LEU H 209
GLN H  30
THR H  45
THR H 201
None
1.28A 2zj0C-4ylqH:
undetectable
2zj0C-4ylqH:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA


(Homo sapiens)
PF00626
(Gelsolin)
4 LEU G  47
GLN G  58
THR G  49
THR G  81
None
0.99A 2zj0C-4z94G:
undetectable
2zj0C-4z94G:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zjg ALPHA-2-MACROGLOBULI
N


(Escherichia
coli)
PF11974
(MG1)
4 LEU A 344
GLN A 333
THR A 332
HIS A 341
None
None
None
PGE  A 402 (-4.2A)
0.95A 2zj0C-4zjgA:
undetectable
2zj0C-4zjgA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a1m ADSEVERIN

(Homo sapiens)
PF00626
(Gelsolin)
4 LEU A 317
GLN A 292
THR A 326
THR A 312
None
1.36A 2zj0C-5a1mA:
undetectable
2zj0C-5a1mA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT


(Pseudomonas
protegens)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
4 LEU A 163
GLN A 101
THR A  99
THR A 128
None
1.36A 2zj0C-5ahkA:
undetectable
2zj0C-5ahkA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE


(Geobacillus
stearothermophilus)
PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C)
4 LEU A 130
GLN A 165
THR A 163
THR A 125
None
1.40A 2zj0C-5c3mA:
5.5
2zj0C-5c3mA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6u AMINOTRANSFERASE

(Mycobacterium
tuberculosis)
PF12897
(Aminotran_MocR)
4 LEU A   6
GLN A   9
THR A 419
HIS A  18
None
1.29A 2zj0C-5c6uA:
undetectable
2zj0C-5c6uA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewn STRUCTURAL PROTEIN

(Mamastrovirus 1)
PF03115
(Astro_capsid_N)
4 LEU A 112
GLN A 406
THR A 405
THR A 218
None
1.32A 2zj0C-5ewnA:
undetectable
2zj0C-5ewnA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9p ANTHRONE
OXIDASE-LIKE PROTEIN


(Streptomyces
ambofaciens)
PF03992
(ABM)
4 LEU A 162
GLN A  63
THR A  12
HIS A 159
None
None
None
GOL  A 301 (-3.5A)
1.04A 2zj0C-5f9pA:
undetectable
2zj0C-5f9pA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffn ENZYME SUBTILASE
SUBTY FROM BACILLUS
SP. TY145


(Bacillus sp.
(in: Bacteria))
PF00082
(Peptidase_S8)
4 GLN A   6
THR A   5
THR A  79
HIS A 256
None
1.38A 2zj0C-5ffnA:
4.1
2zj0C-5ffnA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwm HEAT SHOCK PROTEIN
HSP 90 BETA


(Homo sapiens)
PF00183
(HSP90)
PF02518
(HATPase_c)
4 LEU A  98
GLN A 154
THR A 147
THR A 166
None
1.39A 2zj0C-5fwmA:
undetectable
2zj0C-5fwmA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44


(Homo sapiens)
PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6)
4 LEU A 235
GLN A 257
THR A 264
HIS A 323
None
1.30A 2zj0C-5gu6A:
undetectable
2zj0C-5gu6A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htp PROBABLE SUGAR
KINASE


(Synechococcus
elongatus)
PF02782
(FGGY_C)
4 LEU A 386
GLN A 351
THR A 350
THR A 303
None
1.29A 2zj0C-5htpA:
undetectable
2zj0C-5htpA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxy TYROSINE RECOMBINASE
XERA


(Thermoplasma
acidophilum)
PF00589
(Phage_integrase)
PF13495
(Phage_int_SAM_4)
4 LEU A 240
GLN A 262
THR A 265
HIS A 279
None
1.27A 2zj0C-5hxyA:
undetectable
2zj0C-5hxyA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ibv CAPSID POLYPROTEIN
VP90


(Mamastrovirus 1)
PF03115
(Astro_capsid_N)
4 LEU A 112
GLN A 406
THR A 405
THR A 218
None
1.26A 2zj0C-5ibvA:
undetectable
2zj0C-5ibvA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1


(Kribbella
flavida)
PF13416
(SBP_bac_8)
4 LEU A 318
GLN A 342
THR A 338
THR A  51
None
1.16A 2zj0C-5ixpA:
undetectable
2zj0C-5ixpA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6o B-GLUCOSIDASE

(metagenome)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
4 LEU A 608
GLN A 317
THR A 552
HIS A 590
None
1.31A 2zj0C-5k6oA:
undetectable
2zj0C-5k6oA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L38,
MITOCHONDRIAL


(Homo sapiens)
PF01161
(PBP)
4 LEU 6 236
GLN 6 275
THR 6 238
THR 6 300
None
1.39A 2zj0C-5ool6:
undetectable
2zj0C-5ool6:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osh VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29


(Homo sapiens)
no annotation 4 LEU A   9
THR A 136
THR A  37
HIS A  86
None
1.30A 2zj0C-5oshA:
undetectable
2zj0C-5oshA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve8 KAP123

(Kluyveromyces
lactis)
no annotation 4 LEU A 384
GLN A 395
THR A 392
THR A 303
None
1.31A 2zj0C-5ve8A:
undetectable
2zj0C-5ve8A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii)
no annotation 4 LEU A 646
GLN A 349
THR A 590
HIS A 628
None
1.36A 2zj0C-5wugA:
2.2
2zj0C-5wugA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjg VACUOLAR PROTEIN 8

(Saccharomyces
cerevisiae)
PF00514
(Arm)
4 LEU A 259
GLN A 270
THR A 229
HIS A 296
None
None
None
PE5  A 601 (-4.1A)
1.22A 2zj0C-5xjgA:
undetectable
2zj0C-5xjgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt CORE PROTEIN VP6

(Aquareovirus C)
no annotation 4 LEU U 296
GLN U 288
THR U 291
THR U 316
None
1.34A 2zj0C-5zvtU:
undetectable
2zj0C-5zvtU:
10.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6aph ADENOSYLHOMOCYSTEINA
SE


(Elizabethkingia
anophelis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 LEU A  57
GLN A  62
THR A  63
THR A 162
HIS A 306
None
ADN  A 501 (-3.8A)
ADN  A 501 (-4.5A)
NAD  A 500 ( 2.9A)
ADN  A 501 ( 3.7A)
0.30A 2zj0C-6aphA:
56.0
2zj0C-6aphA:
54.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR


(Pseudomonas
aeruginosa)
no annotation 4 GLN A 157
THR A 153
THR A  86
HIS A  80
None
1.40A 2zj0C-6cc0A:
undetectable
2zj0C-6cc0A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cdz THYMIDYLATE SYNTHASE

(Escherichia
coli)
no annotation 4 LEU A 208
GLN A 219
THR A 216
THR A 206
None
1.20A 2zj0C-6cdzA:
undetectable
2zj0C-6cdzA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj POLYADENYLATION
FACTOR SUBUNIT
2,POLYADENYLATION
FACTOR SUBUNIT 2
PROTEIN CFT1


(Saccharomyces
cerevisiae)
no annotation 4 LEU A 944
GLN A 931
THR A 512
HIS D  48
None
1.34A 2zj0C-6eojA:
undetectable
2zj0C-6eojA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eom MUTT/NUDIX FAMILY
PROTEIN


(Caldithrix
abyssi)
no annotation 4 LEU A 318
GLN A 316
THR A 451
HIS A 460
LYS  A 606 ( 4.1A)
NA  A 607 ( 4.9A)
None
None
1.09A 2zj0C-6eomA:
undetectable
2zj0C-6eomA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-)
no annotation 4 GLN B  65
THR B  66
THR B 165
HIS B 323
K  B 504 ( 3.0A)
ADN  B 502 (-4.6A)
NAD  B 501 ( 2.8A)
ZN  B 505 (-3.2A)
0.17A 2zj0C-6f3mB:
51.8
2zj0C-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-)
no annotation 5 LEU A  55
GLN A  60
THR A  61
THR A 160
HIS A 304
None
NA  A 503 ( 3.2A)
ADN  A 501 (-4.6A)
NAD  A 502 ( 2.8A)
ADN  A 501 ( 3.6A)
0.25A 2zj0C-6gbnA:
55.4
2zj0C-6gbnA:
undetectable