SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZJ0_C_2FAC500_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d0n | HORSE PLASMAGELSOLIN (Equus caballus) |
PF00626(Gelsolin) | 4 | LEU A 71GLN A 82THR A 73THR A 105 | None | 1.04A | 2zj0C-1d0nA:undetectable | 2zj0C-1d0nA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ddk | IMP-1 METALLOBETA-LACTAMASE (Pseudomonasaeruginosa) |
PF00753(Lactamase_B) | 4 | GLN A 212THR A 209THR A 140HIS A 77 | NoneNoneNone ZN A 500 (-3.4A) | 1.13A | 2zj0C-1ddkA:2.7 | 2zj0C-1ddkA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e1c | METHYLMALONYL-COAMUTASE ALPHA CHAIN (Propionibacteriumfreudenreichii) |
PF01642(MM_CoA_mutase)PF02310(B12-binding) | 4 | LEU A 668GLN A 643THR A 640THR A 683 | NoneNoneNoneB12 A 800 ( 4.9A) | 1.32A | 2zj0C-1e1cA:2.1 | 2zj0C-1e1cA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j1w | ISOCITRATEDEHYDROGENASE (Azotobactervinelandii) |
PF03971(IDH) | 4 | LEU A 671GLN A 635THR A 632THR A 685 | None | 1.27A | 2zj0C-1j1wA:undetectable | 2zj0C-1j1wA:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jxi | PHOSPHOMETHYLPYRIMIDINE KINASE (Salmonellaenterica) |
PF08543(Phos_pyr_kin) | 4 | LEU A 244THR A 205THR A 214HIS A 261 | None | 1.36A | 2zj0C-1jxiA:4.9 | 2zj0C-1jxiA:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lox | 15-LIPOXYGENASE (Oryctolaguscuniculus) |
PF00305(Lipoxygenase)PF01477(PLAT) | 4 | LEU A 549GLN A 590THR A 553HIS A 545 | NoneNoneNoneFE2 A 840 (-3.3A) | 1.31A | 2zj0C-1loxA:undetectable | 2zj0C-1loxA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qz9 | KYNURENINASE (Pseudomonasfluorescens) |
PF00266(Aminotran_5) | 4 | LEU A 306GLN A 300THR A 301THR A 379 | None | 1.23A | 2zj0C-1qz9A:3.5 | 2zj0C-1qz9A:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r6v | SUBTILISIN-LIKESERINE PROTEASE (Fervidobacteriumpennivorans) |
PF00082(Peptidase_S8) | 4 | LEU A 577GLN A 618THR A 619THR A 572 | None | 1.26A | 2zj0C-1r6vA:4.2 | 2zj0C-1r6vA:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rgi | GELSOLIN (Equus caballus) |
PF00626(Gelsolin) | 4 | LEU G 71GLN G 82THR G 73THR G 105 | None | 1.05A | 2zj0C-1rgiG:undetectable | 2zj0C-1rgiG:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t44 | CHIMERA OF GELSOLINDOMAIN 1 ANDC-TERMINAL DOMAIN OFTHYMOSIN BETA-4 (Homo sapiens;Mus musculus) |
PF00626(Gelsolin)PF01290(Thymosin) | 4 | LEU G 71GLN G 82THR G 73THR G 105 | None | 1.00A | 2zj0C-1t44G:undetectable | 2zj0C-1t44G:13.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ub0 | PHOSPHOMETHYLPYRIMIDINE KINASE (Thermusthermophilus) |
PF08543(Phos_pyr_kin) | 4 | LEU A 241THR A 202THR A 211HIS A 256 | None | 1.34A | 2zj0C-1ub0A:2.7 | 2zj0C-1ub0A:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ut9 | CELLULOSE1,4-BETA-CELLOBIOSIDASE (Ruminiclostridiumthermocellum) |
PF00759(Glyco_hydro_9)PF02927(CelD_N) | 4 | LEU A 476THR A 788THR A 474HIS A 387 | None | 1.13A | 2zj0C-1ut9A:undetectable | 2zj0C-1ut9A:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wwk | PHOSPHOGLYCERATEDEHYDROGENASE (Pyrococcushorikoshii) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 4 | LEU A 107THR A 276THR A 198HIS A 200 | None | 1.36A | 2zj0C-1wwkA:14.6 | 2zj0C-1wwkA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2atm | HYALURONOGLUCOSAMINIDASE (Vespulavulgaris) |
PF01630(Glyco_hydro_56) | 4 | LEU A 91GLN A 43THR A 164HIS A 83 | None | 1.38A | 2zj0C-2atmA:undetectable | 2zj0C-2atmA:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c4k | PHOSPHORIBOSYLPYROPHOSPHATESYNTHETASE-ASSOCIATED PROTEIN 1 (Homo sapiens) |
PF13793(Pribosyltran_N)PF14572(Pribosyl_synth) | 4 | LEU A 22GLN A 64THR A 65THR A 27 | None | 1.25A | 2zj0C-2c4kA:2.4 | 2zj0C-2c4kA:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ff6 | GELSOLIN (Homo sapiens) |
PF00626(Gelsolin) | 4 | LEU G 71GLN G 82THR G 73THR G 105 | None | 0.99A | 2zj0C-2ff6G:undetectable | 2zj0C-2ff6G:14.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gah | HETEROTETRAMERICSARCOSINE OXIDASEALPHA-SUBUNIT (Stenotrophomonasmaltophilia) |
PF01571(GCV_T)PF07992(Pyr_redox_2)PF08669(GCV_T_C)PF13510(Fer2_4) | 4 | LEU A 925GLN A 830THR A 909THR A 835 | None | 1.40A | 2zj0C-2gahA:undetectable | 2zj0C-2gahA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kbb | TALIN-1 (Mus musculus) |
no annotation | 4 | LEU A1741GLN A1764THR A1765THR A1704 | None | 1.08A | 2zj0C-2kbbA:undetectable | 2zj0C-2kbbA:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nvv | ACETYL-COAHYDROLASE/TRANSFERASE FAMILY PROTEIN (Porphyromonasgingivalis) |
PF02550(AcetylCoA_hydro)PF13336(AcetylCoA_hyd_C) | 4 | GLN A 333THR A 107THR A 383HIS A 414 | GLN A 333 ( 0.6A)THR A 107 ( 0.8A)THR A 383 ( 0.8A)HIS A 414 ( 1.0A) | 1.04A | 2zj0C-2nvvA:undetectable | 2zj0C-2nvvA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o26 | MAST/STEM CELLGROWTH FACTORRECEPTOR (Mus musculus) |
no annotation | 4 | GLN X 275THR X 277THR X 306HIS X 222 | None | 1.25A | 2zj0C-2o26X:undetectable | 2zj0C-2o26X:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2okc | TYPE I RESTRICTIONENZYME STYSJI MPROTEIN (Bacteroidesthetaiotaomicron) |
PF02384(N6_Mtase)PF12161(HsdM_N) | 4 | LEU A 18GLN A 25THR A 21THR A 115 | None | 1.24A | 2zj0C-2okcA:5.1 | 2zj0C-2okcA:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wlv | GAG POLYPROTEIN (Humanimmunodeficiencyvirus 2) |
PF00607(Gag_p24) | 4 | LEU B 14THR B 18THR B 47HIS B 11 | None | 1.17A | 2zj0C-2wlvB:undetectable | 2zj0C-2wlvB:13.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xtp | GTPASE IMAP FAMILYMEMBER 2 (Homo sapiens) |
PF04548(AIG1) | 4 | GLN A 121THR A 119THR A 146HIS A 147 | None | 1.39A | 2zj0C-2xtpA:undetectable | 2zj0C-2xtpA:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y7c | TYPE I RESTRICTIONENZYME ECOKI MPROTEIN (Escherichiacoli) |
PF02384(N6_Mtase)PF12161(HsdM_N) | 4 | LEU B 163GLN B 166THR B 358HIS B 335 | None | 1.32A | 2zj0C-2y7cB:3.1 | 2zj0C-2y7cB:23.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yet | GH61 ISOZYME A (Thermoascusaurantiacus) |
PF03443(Glyco_hydro_61) | 4 | LEU A 41GLN A 5THR A 36HIS A 57 | HIC A 1 ( 4.9A)NoneNoneNone | 1.34A | 2zj0C-2yetA:undetectable | 2zj0C-2yetA:18.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bq3 | DEFECTIVE IN CULLINNEDDYLATION PROTEIN1 (Saccharomycescerevisiae) |
PF03556(Cullin_binding)PF14555(UBA_4) | 4 | LEU A 116GLN A 137THR A 133THR A 109 | None | 1.25A | 2zj0C-3bq3A:undetectable | 2zj0C-3bq3A:18.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ce6 | ADENOSYLHOMOCYSTEINASE (Mycobacteriumtuberculosis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | LEU A 68GLN A 73THR A 74THR A 219HIS A 363 | NoneADN A 500 (-3.6A)ADN A 500 (-4.5A)NAD A 550 ( 2.8A)ADN A 500 ( 3.7A) | 0.19A | 2zj0C-3ce6A:66.1 | 2zj0C-3ce6A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cjp | PREDICTEDAMIDOHYDROLASE,DIHYDROOROTASEFAMILY (Clostridiumacetobutylicum) |
PF04909(Amidohydro_2) | 4 | LEU A 32THR A 30THR A 35HIS A 38 | None | 1.30A | 2zj0C-3cjpA:undetectable | 2zj0C-3cjpA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3db2 | PUTATIVENADPH-DEPENDENTOXIDOREDUCTASE (Desulfitobacteriumhafniense) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 4 | LEU A 178GLN A 217THR A 232HIS A 341 | None | 1.28A | 2zj0C-3db2A:7.7 | 2zj0C-3db2A:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3faw | RETICULOCYTE BINDINGPROTEIN (Streptococcusagalactiae) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 4 | LEU A 946GLN A1036THR A1035THR A 922 | NoneNoneNone CL A1223 (-4.3A) | 1.35A | 2zj0C-3fawA:undetectable | 2zj0C-3fawA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g05 | TRNA URIDINE5-CARBOXYMETHYLAMINOMETHYL MODIFICATIONENZYME MNMG (Escherichiacoli) |
PF01134(GIDA)PF13932(GIDA_assoc) | 4 | LEU A 42GLN A 122THR A 36THR A 110 | None | 1.36A | 2zj0C-3g05A:3.0 | 2zj0C-3g05A:22.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3g1u | ADENOSYLHOMOCYSTEINASE (Leishmaniamajor) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | LEU A 51GLN A 56THR A 57THR A 156HIS A 300 | NoneADN A 438 (-3.8A)ADN A 438 (-4.6A)NAD A 439 ( 3.0A)ADN A 438 ( 4.0A) | 0.28A | 2zj0C-3g1uA:53.4 | 2zj0C-3g1uA:54.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gem | SHORT CHAINDEHYDROGENASE (Pseudomonassavastanoi) |
PF13561(adh_short_C2) | 4 | LEU A 78GLN A 74THR A 75HIS A 83 | None | 1.32A | 2zj0C-3gemA:7.2 | 2zj0C-3gemA:17.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3glq | ADENOSYLHOMOCYSTEINASE (Burkholderiapseudomallei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | LEU A 61GLN A 66THR A 67THR A 200HIS A 344 | NoneRAB A 602 (-3.9A)RAB A 602 (-4.5A)NAD A 601 ( 2.9A)RAB A 602 ( 3.5A) | 0.17A | 2zj0C-3glqA:58.6 | 2zj0C-3glqA:57.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gwj | ARYLPHORIN (Antheraeapernyi) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 4 | LEU A 290GLN A 404THR A 405THR A 161 | None | 1.07A | 2zj0C-3gwjA:undetectable | 2zj0C-3gwjA:21.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3h9u | ADENOSYLHOMOCYSTEINASE (Trypanosomabrucei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | LEU A 51GLN A 56THR A 57THR A 156HIS A 300 | NoneADN A 439 (-3.6A)ADN A 439 (-4.7A)NAD A 438 (-3.8A)None | 0.40A | 2zj0C-3h9uA:55.6 | 2zj0C-3h9uA:56.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3il4 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 (Enterococcusfaecalis) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 4 | LEU A 301THR A 14THR A 324HIS A 178 | NoneCSO A 13 ( 3.6A)NoneNone | 1.37A | 2zj0C-3il4A:undetectable | 2zj0C-3il4A:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ll8 | SERINE/THREONINE-PROTEIN PHOSPHATASE 2BCATALYTIC SUBUNITALPHA ISOFORM (Homo sapiens) |
PF00149(Metallophos) | 4 | LEU A 274GLN A 193THR A 208HIS A 271 | None | 1.36A | 2zj0C-3ll8A:undetectable | 2zj0C-3ll8A:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lm6 | STAGE V SPORULATIONPROTEIN AD (Bacillussubtilis) |
PF07451(SpoVAD) | 4 | LEU A 264GLN A 293THR A 232HIS A 258 | None | 1.24A | 2zj0C-3lm6A:undetectable | 2zj0C-3lm6A:22.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3n58 | ADENOSYLHOMOCYSTEINASE (Brucellaabortus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | LEU A 54GLN A 59THR A 60THR A 193HIS A 337 | None K A 2 ( 3.3A)ADN A 500 (-4.6A)NAD A 550 ( 3.0A)ADN A 500 ( 3.6A) | 0.26A | 2zj0C-3n58A:58.7 | 2zj0C-3n58A:60.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nzq | BIOSYNTHETICARGININEDECARBOXYLASE (Escherichiacoli) |
PF02784(Orn_Arg_deC_N) | 4 | LEU A 89GLN A 493THR A 582HIS A 369 | None | 1.35A | 2zj0C-3nzqA:undetectable | 2zj0C-3nzqA:22.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o4z | TELOMERE LENGTHREGULATION PROTEINTEL2 (Saccharomycescerevisiae) |
PF10193(Telomere_reg-2) | 4 | LEU A 544THR A 508THR A 650HIS A 646 | None | 1.39A | 2zj0C-3o4zA:undetectable | 2zj0C-3o4zA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o6b | DEFECTIVE IN CULLINNEDDYLATION PROTEIN1 (Saccharomycescerevisiae) |
PF03556(Cullin_binding) | 4 | LEU A 116GLN A 137THR A 133THR A 109 | None | 1.32A | 2zj0C-3o6bA:undetectable | 2zj0C-3o6bA:16.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3one | ADENOSYLHOMOCYSTEINASE (Lupinus luteus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | LEU A 61GLN A 66THR A 67THR A 206HIS A 350 | NoneADE A 506 (-3.8A)ADE A 506 (-4.5A)NAD A 501 (-2.8A)None | 0.76A | 2zj0C-3oneA:58.2 | 2zj0C-3oneA:59.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pko | GERANYLGERANYLPYROPHOSPHATESYNTHASE (Lactobacillusbrevis) |
PF00348(polyprenyl_synt) | 4 | LEU A 321GLN A 291THR A 294HIS A -2 | None | 1.36A | 2zj0C-3pkoA:undetectable | 2zj0C-3pkoA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qr5 | CARDIAC CA2+ RELEASECHANNEL (Mus musculus) |
PF08709(Ins145_P3_rec) | 4 | GLN A 33THR A 27THR A 210HIS A 193 | None | 1.11A | 2zj0C-3qr5A:undetectable | 2zj0C-3qr5A:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tu5 | GELSOLIN,PROTEINCORDON-BLEU,THYMOSINBETA-4 (Homo sapiens;Mus musculus) |
PF00626(Gelsolin) | 4 | LEU B 47GLN B 58THR B 49THR B 81 | None | 0.99A | 2zj0C-3tu5B:undetectable | 2zj0C-3tu5B:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vmn | DEXTRANASE (Streptococcusmutans) |
PF13199(Glyco_hydro_66) | 4 | LEU A 638GLN A 602THR A 603THR A 635 | None | 1.03A | 2zj0C-3vmnA:2.5 | 2zj0C-3vmnA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bkm | PYRIDOXAL PHOSPHATEPHOSPHATASE,PHOSPHOGLYCOLATEPHOSPHATASE,PYRIDOXAL PHOSPHATEPHOSPHATASE (Mus musculus) |
PF13242(Hydrolase_like)PF13344(Hydrolase_6) | 4 | LEU A 249GLN A 277THR A 263HIS A 257 | None | 1.25A | 2zj0C-4bkmA:3.7 | 2zj0C-4bkmA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bx0 | PYRIDOXAL PHOSPHATEPHOSPHATASE (Mus musculus) |
PF13242(Hydrolase_like)PF13344(Hydrolase_6) | 4 | LEU A 236GLN A 264THR A 250HIS A 244 | None | 1.34A | 2zj0C-4bx0A:3.9 | 2zj0C-4bx0A:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cnk | L-AMINO ACID OXIDASE (Streptococcuscristatus) |
PF03486(HI0933_like) | 4 | GLN A 156THR A 6THR A 348HIS A 389 | None | 1.12A | 2zj0C-4cnkA:undetectable | 2zj0C-4cnkA:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4czw | PAB-DEPENDENTPOLY(A)-SPECIFICRIBONUCLEASE SUBUNITPAN2 (Neurosporacrassa) |
PF00929(RNase_T)PF13423(UCH_1) | 4 | LEU A 531THR A 986THR A 528HIS A 525 | NoneNoneNone ZN A3094 (-3.1A) | 1.26A | 2zj0C-4czwA:undetectable | 2zj0C-4czwA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f92 | U5 SMALL NUCLEARRIBONUCLEOPROTEIN200 KDA HELICASE (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C)PF02889(Sec63) | 4 | LEU B1781GLN B1766THR B1765THR B1756 | None | 1.18A | 2zj0C-4f92B:undetectable | 2zj0C-4f92B:14.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gmf | YERSINIABACTINBIOSYNTHETIC PROTEINYBTU (Yersiniaenterocolitica) |
PF01408(GFO_IDH_MocA) | 4 | LEU A 168GLN A 331THR A 179HIS A 322 | None | 1.01A | 2zj0C-4gmfA:5.4 | 2zj0C-4gmfA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h63 | MEDIATOR OF RNAPOLYMERASE IITRANSCRIPTIONSUBUNIT 17 (Schizosaccharomycespombe) |
PF10156(Med17) | 4 | LEU Q 347GLN Q 263THR Q 349HIS Q 394 | None | 1.16A | 2zj0C-4h63Q:undetectable | 2zj0C-4h63Q:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hkt | INOSITOL2-DEHYDROGENASE (Sinorhizobiummeliloti) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 4 | LEU A 183GLN A 216THR A 217THR A 147 | None | 1.35A | 2zj0C-4hktA:9.3 | 2zj0C-4hktA:24.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4htw | GAG PROTEIN (Simianimmunodeficiencyvirus) |
PF00607(Gag_p24) | 4 | LEU A 14THR A 18THR A 47HIS A 11 | None | 1.19A | 2zj0C-4htwA:undetectable | 2zj0C-4htwA:14.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l1m | E3 UBIQUITIN-PROTEINLIGASE HERC2 (Homo sapiens) |
PF00415(RCC1) | 4 | LEU A 600GLN A 625THR A 621THR A 647 | NoneNoneNoneSO4 A 802 (-3.5A) | 1.06A | 2zj0C-4l1mA:undetectable | 2zj0C-4l1mA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lct | COP9 SIGNALOSOMECOMPLEX SUBUNIT 1 (Arabidopsisthaliana) |
PF01399(PCI)PF10602(RPN7) | 4 | LEU A 228GLN A 191THR A 193HIS A 330 | None | 1.30A | 2zj0C-4lctA:undetectable | 2zj0C-4lctA:21.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lvc | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE(SAHASE) (Bradyrhizobiumelkanii) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | LEU A 57GLN A 62THR A 63THR A 198HIS A 342 | NoneNH4 A 502 ( 3.1A)ADN A 501 (-4.5A)NAD A 503 ( 2.9A)ADN A 501 ( 3.7A) | 0.24A | 2zj0C-4lvcA:59.2 | 2zj0C-4lvcA:58.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4maa | PUTATIVEBRANCHED-CHAIN AMINOACID ABCTRANSPORTER,PERIPLASMIC AMINOACID-BINDING PROTEIN (Pseudomonasprotegens) |
PF13458(Peripla_BP_6) | 4 | LEU A 292GLN A 297THR A 296THR A 286 | None | 1.28A | 2zj0C-4maaA:5.7 | 2zj0C-4maaA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mca | GLYCEROLDEHYDROGENASE (Serratiaplymuthica) |
PF00465(Fe-ADH) | 4 | LEU A 173GLN A 282THR A 279THR A 295 | None | 1.35A | 2zj0C-4mcaA:2.4 | 2zj0C-4mcaA:23.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4om9 | SERINE PROTEASE PET (Escherichiacoli) |
PF02395(Peptidase_S6) | 4 | LEU A 388GLN A 375THR A 393THR A 385 | None | 1.08A | 2zj0C-4om9A:undetectable | 2zj0C-4om9A:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pkh | GELSOLIN,TROPOMODULIN-1 CHIMERA (Homo sapiens) |
PF00626(Gelsolin)PF03250(Tropomodulin) | 4 | LEU B 98GLN B 109THR B 100THR B 132 | None | 1.02A | 2zj0C-4pkhB:undetectable | 2zj0C-4pkhB:16.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pki | GELSOLIN,TROPOMODULIN-1 CHIMERA (Homo sapiens) |
PF00626(Gelsolin) | 4 | LEU G 98GLN G 109THR G 100THR G 132 | None | 1.03A | 2zj0C-4pkiG:undetectable | 2zj0C-4pkiG:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ql6 | CARBOXY-TERMINALPROCESSING PROTEASE (Chlamydiatrachomatis) |
PF00595(PDZ)PF03572(Peptidase_S41) | 4 | GLN A 477THR A 478THR A 483HIS A 231 | None | 1.31A | 2zj0C-4ql6A:undetectable | 2zj0C-4ql6A:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qlb | PROBABLE GLYCOGEN[STARCH] SYNTHASE (Caenorhabditiselegans) |
PF05693(Glycogen_syn) | 4 | LEU A 214GLN A 153THR A 218HIS A 271 | None | 1.33A | 2zj0C-4qlbA:4.4 | 2zj0C-4qlbA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ubq | BETA-LACTAMASE (Acinetobacterbaumannii) |
no annotation | 4 | GLN A 213THR A 210THR A 141HIS A 78 | NoneNoneNone ZN A 301 (-3.4A) | 1.23A | 2zj0C-4ubqA:3.0 | 2zj0C-4ubqA:18.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xz8 | NUCLEOPROTEIN (Thiaforaorthonairovirus) |
PF02477(Nairo_nucleo) | 4 | LEU A 452GLN A 159THR A 472THR A 413 | None | 1.22A | 2zj0C-4xz8A:undetectable | 2zj0C-4xz8A:23.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y9v | PARTICLE-ASSOCIATEDLYASE (Acinetobactervirus AP22) |
no annotation | 4 | LEU A 501THR A 497THR A 540HIS A 572 | None | 1.32A | 2zj0C-4y9vA:undetectable | 2zj0C-4y9vA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ylq | COAGULATION FACTORVII (Homo sapiens) |
PF00089(Trypsin) | 4 | LEU H 209GLN H 30THR H 45THR H 201 | None | 1.28A | 2zj0C-4ylqH:undetectable | 2zj0C-4ylqH:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z94 | GELSOLIN,TROPOMODULIN-1,LEIOMODIN-1 CHIMERA (Homo sapiens) |
PF00626(Gelsolin) | 4 | LEU G 47GLN G 58THR G 49THR G 81 | None | 0.99A | 2zj0C-4z94G:undetectable | 2zj0C-4z94G:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zjg | ALPHA-2-MACROGLOBULIN (Escherichiacoli) |
PF11974(MG1) | 4 | LEU A 344GLN A 333THR A 332HIS A 341 | NoneNoneNonePGE A 402 (-4.2A) | 0.95A | 2zj0C-4zjgA:undetectable | 2zj0C-4zjgA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a1m | ADSEVERIN (Homo sapiens) |
PF00626(Gelsolin) | 4 | LEU A 317GLN A 292THR A 326THR A 312 | None | 1.36A | 2zj0C-5a1mA:undetectable | 2zj0C-5a1mA:14.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ahk | ACETOLACTATESYNTHASE II, LARGESUBUNIT (Pseudomonasprotegens) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 4 | LEU A 163GLN A 101THR A 99THR A 128 | None | 1.36A | 2zj0C-5ahkA:undetectable | 2zj0C-5ahkA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c3m | PUTATIVE6-PHOSPHO-BETA-GLUCOSIDASE (Geobacillusstearothermophilus) |
PF02056(Glyco_hydro_4)PF11975(Glyco_hydro_4C) | 4 | LEU A 130GLN A 165THR A 163THR A 125 | None | 1.40A | 2zj0C-5c3mA:5.5 | 2zj0C-5c3mA:22.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c6u | AMINOTRANSFERASE (Mycobacteriumtuberculosis) |
PF12897(Aminotran_MocR) | 4 | LEU A 6GLN A 9THR A 419HIS A 18 | None | 1.29A | 2zj0C-5c6uA:undetectable | 2zj0C-5c6uA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ewn | STRUCTURAL PROTEIN (Mamastrovirus 1) |
PF03115(Astro_capsid_N) | 4 | LEU A 112GLN A 406THR A 405THR A 218 | None | 1.32A | 2zj0C-5ewnA:undetectable | 2zj0C-5ewnA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f9p | ANTHRONEOXIDASE-LIKE PROTEIN (Streptomycesambofaciens) |
PF03992(ABM) | 4 | LEU A 162GLN A 63THR A 12HIS A 159 | NoneNoneNoneGOL A 301 (-3.5A) | 1.04A | 2zj0C-5f9pA:undetectable | 2zj0C-5f9pA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ffn | ENZYME SUBTILASESUBTY FROM BACILLUSSP. TY145 (Bacillus sp.(in: Bacteria)) |
PF00082(Peptidase_S8) | 4 | GLN A 6THR A 5THR A 79HIS A 256 | None | 1.38A | 2zj0C-5ffnA:4.1 | 2zj0C-5ffnA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fwm | HEAT SHOCK PROTEINHSP 90 BETA (Homo sapiens) |
PF00183(HSP90)PF02518(HATPase_c) | 4 | LEU A 98GLN A 154THR A 147THR A 166 | None | 1.39A | 2zj0C-5fwmA:undetectable | 2zj0C-5fwmA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gu6 | ENDOPLASMICRETICULUM RESIDENTPROTEIN 44 (Homo sapiens) |
PF00085(Thioredoxin)PF13848(Thioredoxin_6) | 4 | LEU A 235GLN A 257THR A 264HIS A 323 | None | 1.30A | 2zj0C-5gu6A:undetectable | 2zj0C-5gu6A:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5htp | PROBABLE SUGARKINASE (Synechococcuselongatus) |
PF02782(FGGY_C) | 4 | LEU A 386GLN A 351THR A 350THR A 303 | None | 1.29A | 2zj0C-5htpA:undetectable | 2zj0C-5htpA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hxy | TYROSINE RECOMBINASEXERA (Thermoplasmaacidophilum) |
PF00589(Phage_integrase)PF13495(Phage_int_SAM_4) | 4 | LEU A 240GLN A 262THR A 265HIS A 279 | None | 1.27A | 2zj0C-5hxyA:undetectable | 2zj0C-5hxyA:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ibv | CAPSID POLYPROTEINVP90 (Mamastrovirus 1) |
PF03115(Astro_capsid_N) | 4 | LEU A 112GLN A 406THR A 405THR A 218 | None | 1.26A | 2zj0C-5ibvA:undetectable | 2zj0C-5ibvA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ixp | EXTRACELLULARSOLUTE-BINDINGPROTEIN FAMILY 1 (Kribbellaflavida) |
PF13416(SBP_bac_8) | 4 | LEU A 318GLN A 342THR A 338THR A 51 | None | 1.16A | 2zj0C-5ixpA:undetectable | 2zj0C-5ixpA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k6o | B-GLUCOSIDASE (metagenome) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 4 | LEU A 608GLN A 317THR A 552HIS A 590 | None | 1.31A | 2zj0C-5k6oA:undetectable | 2zj0C-5k6oA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ool | 39S RIBOSOMALPROTEIN L38,MITOCHONDRIAL (Homo sapiens) |
PF01161(PBP) | 4 | LEU 6 236GLN 6 275THR 6 238THR 6 300 | None | 1.39A | 2zj0C-5ool6:undetectable | 2zj0C-5ool6:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5osh | VACUOLAR PROTEINSORTING-ASSOCIATEDPROTEIN 29 (Homo sapiens) |
no annotation | 4 | LEU A 9THR A 136THR A 37HIS A 86 | None | 1.30A | 2zj0C-5oshA:undetectable | 2zj0C-5oshA:9.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ve8 | KAP123 (Kluyveromyceslactis) |
no annotation | 4 | LEU A 384GLN A 395THR A 392THR A 303 | None | 1.31A | 2zj0C-5ve8A:undetectable | 2zj0C-5ve8A:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wug | BETA-GLUCOSIDASE (Paenibacillusbarengoltzii) |
no annotation | 4 | LEU A 646GLN A 349THR A 590HIS A 628 | None | 1.36A | 2zj0C-5wugA:2.2 | 2zj0C-5wugA:8.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xjg | VACUOLAR PROTEIN 8 (Saccharomycescerevisiae) |
PF00514(Arm) | 4 | LEU A 259GLN A 270THR A 229HIS A 296 | NoneNoneNonePE5 A 601 (-4.1A) | 1.22A | 2zj0C-5xjgA:undetectable | 2zj0C-5xjgA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zvt | CORE PROTEIN VP6 (Aquareovirus C) |
no annotation | 4 | LEU U 296GLN U 288THR U 291THR U 316 | None | 1.34A | 2zj0C-5zvtU:undetectable | 2zj0C-5zvtU:10.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6aph | ADENOSYLHOMOCYSTEINASE (Elizabethkingiaanophelis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | LEU A 57GLN A 62THR A 63THR A 162HIS A 306 | NoneADN A 501 (-3.8A)ADN A 501 (-4.5A)NAD A 500 ( 2.9A)ADN A 501 ( 3.7A) | 0.30A | 2zj0C-6aphA:56.0 | 2zj0C-6aphA:54.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cc0 | LUXR FAMILYTRANSCRIPTIONALREGULATOR (Pseudomonasaeruginosa) |
no annotation | 4 | GLN A 157THR A 153THR A 86HIS A 80 | None | 1.40A | 2zj0C-6cc0A:undetectable | 2zj0C-6cc0A:8.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cdz | THYMIDYLATE SYNTHASE (Escherichiacoli) |
no annotation | 4 | LEU A 208GLN A 219THR A 216THR A 206 | None | 1.20A | 2zj0C-6cdzA:undetectable | 2zj0C-6cdzA:12.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eoj | POLYADENYLATIONFACTOR SUBUNIT2,POLYADENYLATIONFACTOR SUBUNIT 2PROTEIN CFT1 (Saccharomycescerevisiae) |
no annotation | 4 | LEU A 944GLN A 931THR A 512HIS D 48 | None | 1.34A | 2zj0C-6eojA:undetectable | 2zj0C-6eojA:16.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eom | MUTT/NUDIX FAMILYPROTEIN (Caldithrixabyssi) |
no annotation | 4 | LEU A 318GLN A 316THR A 451HIS A 460 | LYS A 606 ( 4.1A) NA A 607 ( 4.9A)NoneNone | 1.09A | 2zj0C-6eomA:undetectable | 2zj0C-6eomA:11.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f3m | - (-) |
no annotation | 4 | GLN B 65THR B 66THR B 165HIS B 323 | K B 504 ( 3.0A)ADN B 502 (-4.6A)NAD B 501 ( 2.8A) ZN B 505 (-3.2A) | 0.17A | 2zj0C-6f3mB:51.8 | 2zj0C-6f3mB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gbn | - (-) |
no annotation | 5 | LEU A 55GLN A 60THR A 61THR A 160HIS A 304 | None NA A 503 ( 3.2A)ADN A 501 (-4.6A)NAD A 502 ( 2.8A)ADN A 501 ( 3.6A) | 0.25A | 2zj0C-6gbnA:55.4 | 2zj0C-6gbnA:undetectable |