SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZJ0_C_2FAC500_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eqw | CU,ZN SUPEROXIDEDISMUTASE (Salmonellaenterica) |
PF00080(Sod_Cu) | 5 | HIS A 78ASP A 81LEU A 135GLY A 60HIS A 46 | ZN A 501 (-3.0A) ZN A 501 (-2.4A)NoneNone CU A 502 (-3.2A) | 1.10A | 2zj0C-1eqwA:undetectable | 2zj0C-1eqwA:15.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eso | CU, ZN SUPEROXIDEDISMUTASE (Escherichiacoli) |
PF00080(Sod_Cu) | 5 | HIS A 78ASP A 81LEU A 135GLY A 60HIS A 46 | ZN A 149 ( 3.0A) ZN A 149 ( 2.4A)NoneNone CU A 150 ( 3.3A) | 1.14A | 2zj0C-1esoA:undetectable | 2zj0C-1esoA:16.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oal | SUPEROXIDE DISMUTASE (Photobacteriumleiognathi) |
PF00080(Sod_Cu) | 5 | HIS A 88ASP A 91LEU A 138GLY A 69HIS A 47 | ZN A 152 (-3.0A) ZN A 152 (-2.2A)NoneNone CU A 153 (-3.1A) | 1.14A | 2zj0C-1oalA:undetectable | 2zj0C-1oalA:15.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tkk | SIMILAR TOCHLOROMUCONATECYCLOISOMERASE (Bacillussubtilis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ASP A 244GLU A 219LYS A 160LEU A 23GLY A 195 | MG A1601 ( 3.2A) MG A1601 (-2.9A)GLU A2471 (-2.6A)NoneNone | 1.41A | 2zj0C-1tkkA:undetectable | 2zj0C-1tkkA:24.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1v8b | ADENOSYLHOMOCYSTEINASE (Plasmodiumfalciparum) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | ASP A 134GLU A 200LYS A 230ASP A 234LEU A 392HIS A 398 | ADN A 502 (-3.1A)ADN A 502 (-4.0A)ADN A 502 (-3.0A)ADN A 502 (-2.8A)ADN A 502 ( 4.9A)ADN A 502 ( 3.5A) | 1.30A | 2zj0C-1v8bA:58.1 | 2zj0C-1v8bA:54.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1v8b | ADENOSYLHOMOCYSTEINASE (Plasmodiumfalciparum) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 12 | HIS A 54THR A 56ASP A 134GLU A 200LYS A 230ASP A 234LEU A 389LEU A 392GLY A 397HIS A 398MET A 403PHE A 407 | ADN A 502 (-4.1A)ADN A 502 (-3.0A)ADN A 502 (-3.1A)ADN A 502 (-4.0A)ADN A 502 (-3.0A)ADN A 502 (-2.8A)NAD A 501 ( 3.8A)ADN A 502 ( 4.9A)ADN A 502 ( 3.7A)ADN A 502 ( 3.5A)ADN A 502 (-3.6A)None | 0.60A | 2zj0C-1v8bA:58.1 | 2zj0C-1v8bA:54.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z9n | SUPEROXIDE DISMUTASE[CU-ZN] ([Haemophilus]ducreyi) |
PF00080(Sod_Cu) | 5 | HIS A 113ASP A 116LEU A 164GLY A 94HIS A 72 | ZN A 201 (-3.1A) ZN A 201 (-2.1A)NoneNone CU A 200 (-3.2A) | 1.11A | 2zj0C-1z9nA:undetectable | 2zj0C-1z9nA:14.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aps | PROTEIN (CU,ZNSUPEROXIDEDISMUTASE) (Actinobacilluspleuropneumoniae) |
PF00080(Sod_Cu) | 5 | HIS A 103ASP A 106LEU A 154GLY A 84HIS A 62 | ZN A 400 ( 3.2A) ZN A 400 (-2.2A)NoneNone CU A 402 ( 3.4A) | 1.09A | 2zj0C-2apsA:undetectable | 2zj0C-2apsA:16.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aqt | SUPEROXIDE DISMUTASE[CU-ZN] (Neisseriameningitidis) |
no annotation | 5 | HIS C 122ASP C 125LEU C 173GLY C 103HIS C 81 | ZN C 201 (-3.1A) ZN C 201 (-2.2A)NoneNoneCU1 C 200 (-3.3A) | 1.16A | 2zj0C-2aqtC:undetectable | 2zj0C-2aqtC:15.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ci6 | NG,NG-DIMETHYLARGININEDIMETHYLAMINOHYDROLASE 1 (Bos taurus) |
PF02274(Amidinotransf) | 5 | ASP A 253LEU A 211LEU A 184GLY A 181HIS A 254 | None | 1.49A | 2zj0C-2ci6A:undetectable | 2zj0C-2ci6A:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cn3 | BETA-1,4-XYLOGLUCANHYDROLASE (Ruminiclostridiumthermocellum) |
PF02012(BNR) | 5 | HIS A 275THR A 287ASP A 414GLU A 416GLY A 276 | NoneNone CA A1778 (-2.2A) CA A1778 (-3.2A)None | 1.37A | 2zj0C-2cn3A:undetectable | 2zj0C-2cn3A:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jii | SERINE/THREONINE-PROTEIN KINASE VRK3MOLECULE: VACCINIARELATED KINASE 3 (Homo sapiens) |
PF00069(Pkinase) | 5 | HIS A 304GLU A 214LYS A 203LEU A 324PHE A 218 | None | 1.34A | 2zj0C-2jiiA:undetectable | 2zj0C-2jiiA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2okx | RHAMNOSIDASE B (Bacillus sp.GL1) |
PF05592(Bac_rhamnosid)PF08531(Bac_rhamnosid_N)PF17389(Bac_rhamnosid6H)PF17390(Bac_rhamnosid_C) | 5 | THR A 530GLU A 535LEU A 203HIS A 555PHE A 591 | NoneNoneNoneGOL A3035 (-3.7A)None | 1.33A | 2zj0C-2okxA:undetectable | 2zj0C-2okxA:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pqd | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Agrobacteriumsp.) |
PF00275(EPSP_synthase) | 5 | THR A 275ASP A 300GLU A 299LYS A 205ASP A 201 | None | 1.16A | 2zj0C-2pqdA:undetectable | 2zj0C-2pqdA:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vun | ENAMIDASE (Eubacteriumbarkeri) |
PF01979(Amidohydro_1) | 5 | THR A 315ASP A 332GLU A 330LEU A 64HIS A 136 | None | 1.50A | 2zj0C-2vunA:undetectable | 2zj0C-2vunA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wab | ENDOGLUCANASE E (Ruminiclostridiumthermocellum) |
PF00657(Lipase_GDSL) | 5 | HIS A 316THR A 315GLY A 306HIS A 310MET A 263 | NoneGOL A1341 (-3.7A)NoneBGC A1338 (-4.0A)BGC A1337 (-4.5A) | 1.35A | 2zj0C-2wabA:4.8 | 2zj0C-2wabA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wwo | SUPEROXIDE DISMUTASE[CU-ZN] (Yersiniapseudotuberculosis) |
PF00080(Sod_Cu) | 5 | HIS A 97ASP A 100LEU A 148GLY A 78HIS A 56 | ZN A1162 (-3.2A) ZN A1162 (-2.3A)NoneNone ZN A1165 (-3.4A) | 1.17A | 2zj0C-2wwoA:undetectable | 2zj0C-2wwoA:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wyx | BETA-LACTAMSE TOHO-1 (Escherichiacoli) |
PF13354(Beta-lactamase2) | 5 | THR A 194ASP A 246LEU A 127LEU A 211GLY A 232 | None | 1.44A | 2zj0C-2wyxA:undetectable | 2zj0C-2wyxA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xsr | CATECHOL 1,2DIOXYGENASE (Acinetobacterradioresistens) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 5 | ASP A 246LEU A 207GLY A 214HIS A 213PHE A 250 | None | 1.29A | 2zj0C-2xsrA:undetectable | 2zj0C-2xsrA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zux | YESW PROTEIN (Bacillussubtilis) |
no annotation | 5 | GLU A 502ASP A 498LEU A 575LEU A 605GLY A 606 | CA A 632 (-2.2A) CA A 632 (-3.3A)NoneNoneNone | 1.46A | 2zj0C-2zuxA:undetectable | 2zj0C-2zuxA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b1r | RIBOKINASE, PUTATIVE (Burkholderiathailandensis) |
PF00294(PfkB) | 5 | THR A 271ASP A 300LEU A 60GLY A 262HIS A 265 | None | 1.14A | 2zj0C-3b1rA:4.4 | 2zj0C-3b1rA:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bfg | CLASS ABETA-LACTAMASE SED1 (Citrobactersedlakii) |
PF13354(Beta-lactamase2) | 5 | THR A 194ASP A 246LEU A 127LEU A 211GLY A 232 | None | 1.48A | 2zj0C-3bfgA:undetectable | 2zj0C-3bfgA:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3byd | BETA-LACTAMASE OXY-1 (Klebsiellaoxytoca) |
PF13354(Beta-lactamase2) | 5 | THR A 197ASP A 248LEU A 130LEU A 214GLY A 235 | None | 1.45A | 2zj0C-3bydA:undetectable | 2zj0C-3bydA:22.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ce6 | ADENOSYLHOMOCYSTEINASE (Mycobacteriumtuberculosis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | ASP A 156GLU A 218LYS A 248ASP A 252LEU A 410HIS A 416 | ADN A 500 (-2.9A)ADN A 500 (-2.6A)ADN A 500 (-2.8A)ADN A 500 (-2.7A)ADN A 500 ( 4.8A)ADN A 500 ( 3.6A) | 1.31A | 2zj0C-3ce6A:66.1 | 2zj0C-3ce6A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ce6 | ADENOSYLHOMOCYSTEINASE (Mycobacteriumtuberculosis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 12 | HIS A 69THR A 71ASP A 156GLU A 218LYS A 248ASP A 252LEU A 407LEU A 410GLY A 415HIS A 416MET A 421PHE A 425 | ADN A 500 (-4.0A)ADN A 500 (-2.8A)ADN A 500 (-2.9A)ADN A 500 (-2.6A)ADN A 500 (-2.8A)ADN A 500 (-2.7A)NAD A 550 (-4.2A)ADN A 500 ( 4.8A)ADN A 500 ( 3.6A)ADN A 500 ( 3.6A)ADN A 500 (-3.7A)ADN A 500 (-4.8A) | 0.25A | 2zj0C-3ce6A:66.1 | 2zj0C-3ce6A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ce6 | ADENOSYLHOMOCYSTEINASE (Mycobacteriumtuberculosis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | HIS A 69THR A 74ASP A 156ASP A 252LEU A 407 | ADN A 500 (-4.0A)ADN A 500 (-4.5A)ADN A 500 (-2.9A)ADN A 500 (-2.7A)NAD A 550 (-4.2A) | 1.38A | 2zj0C-3ce6A:66.1 | 2zj0C-3ce6A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3g1u | ADENOSYLHOMOCYSTEINASE (Leishmaniamajor) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 10 | HIS A 52THR A 54ASP A 130GLU A 155LEU A 343LEU A 346GLY A 351HIS A 352MET A 357PHE A 361 | ADN A 438 (-4.0A)ADN A 438 (-2.8A)ADN A 438 (-4.1A)ADN A 438 (-3.8A)NAD A 439 ( 4.0A)ADN A 438 ( 4.8A)ADN A 438 ( 3.8A)ADN A 438 ( 3.6A)ADN A 438 (-3.7A)None | 0.69A | 2zj0C-3g1uA:53.4 | 2zj0C-3g1uA:54.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3g1u | ADENOSYLHOMOCYSTEINASE (Leishmaniamajor) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | HIS A 52THR A 57ASP A 130LEU A 343MET A 357 | ADN A 438 (-4.0A)ADN A 438 (-4.6A)ADN A 438 (-4.1A)NAD A 439 ( 4.0A)ADN A 438 (-3.7A) | 1.48A | 2zj0C-3g1uA:53.4 | 2zj0C-3g1uA:54.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3glq | ADENOSYLHOMOCYSTEINASE (Burkholderiapseudomallei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | ASP A 139GLU A 199LYS A 229ASP A 233LEU A 388HIS A 394 | RAB A 602 (-3.0A)RAB A 602 (-4.6A)RAB A 602 (-3.0A)RAB A 602 (-2.5A)RAB A 602 ( 4.7A)NAD A 601 ( 3.6A) | 1.36A | 2zj0C-3glqA:58.6 | 2zj0C-3glqA:57.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3glq | ADENOSYLHOMOCYSTEINASE (Burkholderiapseudomallei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 12 | HIS A 62THR A 64ASP A 139GLU A 199LYS A 229ASP A 233LEU A 385LEU A 388GLY A 393HIS A 394MET A 399PHE A 403 | RAB A 602 (-3.8A)RAB A 602 (-2.7A)RAB A 602 (-3.0A)RAB A 602 (-4.6A)RAB A 602 (-3.0A)RAB A 602 (-2.5A)NAD A 601 ( 4.1A)RAB A 602 ( 4.7A)RAB A 602 ( 3.8A)NAD A 601 ( 3.6A)RAB A 602 (-3.6A)None | 0.47A | 2zj0C-3glqA:58.6 | 2zj0C-3glqA:57.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3glq | ADENOSYLHOMOCYSTEINASE (Burkholderiapseudomallei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | HIS A 62THR A 67ASP A 139LEU A 385MET A 399 | RAB A 602 (-3.8A)RAB A 602 (-4.5A)RAB A 602 (-3.0A)NAD A 601 ( 4.1A)RAB A 602 (-3.6A) | 1.46A | 2zj0C-3glqA:58.6 | 2zj0C-3glqA:57.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3goh | ALCOHOLDEHYDROGENASE,ZINC-CONTAINING (Shewanellaoneidensis) |
PF08240(ADH_N) | 5 | ASP A 64LEU A 128LEU A 250GLY A 251HIS A 254 | NoneNoneGOL A 316 (-4.7A)GOL A 316 (-2.9A)None | 1.39A | 2zj0C-3gohA:9.3 | 2zj0C-3gohA:21.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3h9u | ADENOSYLHOMOCYSTEINASE (Trypanosomabrucei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | ASP A 130GLU A 155LYS A 185ASP A 189LEU A 346HIS A 352 | NoneNoneNAD A 438 ( 3.9A)NAD A 438 ( 4.4A)ADN A 439 ( 4.7A)ADN A 439 ( 3.3A) | 1.41A | 2zj0C-3h9uA:55.6 | 2zj0C-3h9uA:56.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3h9u | ADENOSYLHOMOCYSTEINASE (Trypanosomabrucei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 12 | HIS A 52THR A 54ASP A 130GLU A 155LYS A 185ASP A 189LEU A 343LEU A 346GLY A 351HIS A 352MET A 357PHE A 361 | ADN A 439 ( 4.7A)ADN A 439 (-2.7A)NoneNoneNAD A 438 ( 3.9A)NAD A 438 ( 4.4A)NAD A 438 (-4.0A)ADN A 439 ( 4.7A)ADN A 439 (-3.5A)ADN A 439 ( 3.3A)ADN A 439 ( 3.7A)None | 0.55A | 2zj0C-3h9uA:55.6 | 2zj0C-3h9uA:56.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k6j | PROTEIN F01G10.3,CONFIRMED BYTRANSCRIPT EVIDENCE (Caenorhabditiselegans) |
PF00725(3HCDH)PF02737(3HCDH_N) | 5 | GLU A 287LYS A 276HIS A 227MET A 272PHE A 269 | None | 1.40A | 2zj0C-3k6jA:7.0 | 2zj0C-3k6jA:22.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3n58 | ADENOSYLHOMOCYSTEINASE (Brucellaabortus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | ASP A 132GLU A 192LYS A 222ASP A 226LEU A 381HIS A 387 | ADN A 500 (-3.3A)ADN A 500 (-3.6A)ADN A 500 (-2.7A)ADN A 500 ( 2.6A)ADN A 500 ( 4.8A)ADN A 500 (-3.4A) | 1.39A | 2zj0C-3n58A:58.7 | 2zj0C-3n58A:60.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3n58 | ADENOSYLHOMOCYSTEINASE (Brucellaabortus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 12 | HIS A 55THR A 57ASP A 132GLU A 192LYS A 222ASP A 226LEU A 378LEU A 381GLY A 386HIS A 387MET A 392PHE A 396 | ADN A 500 (-4.0A)ADN A 500 (-2.8A)ADN A 500 (-3.3A)ADN A 500 (-3.6A)ADN A 500 (-2.7A)ADN A 500 ( 2.6A)NAD A 550 (-4.3A)ADN A 500 ( 4.8A)ADN A 500 (-3.7A)ADN A 500 (-3.4A)ADN A 500 (-3.7A)None | 0.53A | 2zj0C-3n58A:58.7 | 2zj0C-3n58A:60.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3n58 | ADENOSYLHOMOCYSTEINASE (Brucellaabortus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | HIS A 55THR A 60ASP A 132ASP A 226LEU A 378 | ADN A 500 (-4.0A)ADN A 500 (-4.6A)ADN A 500 (-3.3A)ADN A 500 ( 2.6A)NAD A 550 (-4.3A) | 1.33A | 2zj0C-3n58A:58.7 | 2zj0C-3n58A:60.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o98 | BIFUNCTIONALGLUTATHIONYLSPERMIDINESYNTHETASE/AMIDASE (Escherichiacoli) |
PF03738(GSP_synth)PF05257(CHAP) | 5 | THR A 446ASP A 387GLU A 392LEU A 416LEU A 475 | None | 1.35A | 2zj0C-3o98A:undetectable | 2zj0C-3o98A:23.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3one | ADENOSYLHOMOCYSTEINASE (Lupinus luteus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | ASP A 139GLU A 205LYS A 235ASP A 239LEU A 398HIS A 404 | NoneNoneNAD A 501 ( 4.2A)NAD A 501 ( 4.5A)ADE A 506 ( 4.7A)ADE A 506 (-3.4A) | 1.37A | 2zj0C-3oneA:58.2 | 2zj0C-3oneA:59.52 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3one | ADENOSYLHOMOCYSTEINASE (Lupinus luteus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | HIS A 62ASP A 139LYS A 235ASP A 239LEU A 395 | ADE A 506 (-4.6A)NoneNAD A 501 ( 4.2A)NAD A 501 ( 4.5A)NAD A 501 (-4.2A) | 1.38A | 2zj0C-3oneA:58.2 | 2zj0C-3oneA:59.52 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3one | ADENOSYLHOMOCYSTEINASE (Lupinus luteus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 12 | HIS A 62THR A 64ASP A 139GLU A 205LYS A 235ASP A 239LEU A 395LEU A 398GLY A 403HIS A 404MET A 409PHE A 413 | ADE A 506 (-4.6A)ADE A 506 (-2.8A)NoneNoneNAD A 501 ( 4.2A)NAD A 501 ( 4.5A)NAD A 501 (-4.2A)ADE A 506 ( 4.7A)ADE A 506 ( 3.6A)ADE A 506 (-3.4A)ADE A 506 (-3.8A)ADE A 506 (-4.9A) | 0.58A | 2zj0C-3oneA:58.2 | 2zj0C-3oneA:59.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p54 | ENVELOPEGLYCOPROTEIN (Japaneseencephalitisvirus) |
PF00869(Flavi_glycoprot)PF02832(Flavi_glycop_C) | 5 | ASP A 42LEU A 371GLY A 145HIS A 144PHE A 1 | None | 1.35A | 2zj0C-3p54A:undetectable | 2zj0C-3p54A:23.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wqb | OPEN READING FRAME 2 (Aeromonassobria) |
no annotation | 5 | THR B 102LEU B 96LEU B 84GLY B 83HIS B 82 | None | 1.31A | 2zj0C-3wqbB:undetectable | 2zj0C-3wqbB:16.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l05 | SUPEROXIDE DISMUTASE[CU-ZN] (Brucellaabortus) |
PF00080(Sod_Cu) | 5 | HIS A 90ASP A 93LEU A 141GLY A 72HIS A 50 | ZN A 203 (-3.1A) ZN A 203 (-2.2A)NoneNoneCU1 A 201 ( 3.2A) | 1.17A | 2zj0C-4l05A:undetectable | 2zj0C-4l05A:13.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lvc | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE(SAHASE) (Bradyrhizobiumelkanii) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | ASP A 135GLU A 197LYS A 227ASP A 231LEU A 386HIS A 392 | ADN A 501 (-3.0A)ADN A 501 (-3.6A)ADN A 501 (-2.7A)ADN A 501 (-3.1A)ADN A 501 ( 4.7A)ADN A 501 (-3.5A) | 1.37A | 2zj0C-4lvcA:59.2 | 2zj0C-4lvcA:58.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lvc | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE(SAHASE) (Bradyrhizobiumelkanii) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 12 | HIS A 58THR A 60ASP A 135GLU A 197LYS A 227ASP A 231LEU A 383LEU A 386GLY A 391HIS A 392MET A 397PHE A 401 | ADN A 501 (-4.0A)ADN A 501 (-2.8A)ADN A 501 (-3.0A)ADN A 501 (-3.6A)ADN A 501 (-2.7A)ADN A 501 (-3.1A)NAD A 503 ( 3.9A)ADN A 501 ( 4.7A)ADN A 501 (-3.6A)ADN A 501 (-3.5A)ADN A 501 (-3.7A)ADN A 501 (-4.8A) | 0.57A | 2zj0C-4lvcA:59.2 | 2zj0C-4lvcA:58.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c92 | KELCHDOMAIN-CONTAININGPROTEIN (Colletotrichumgraminicola) |
PF01344(Kelch_1)PF09118(DUF1929) | 5 | ASP A 343LEU A 28LEU A 21GLY A 26PHE A 464 | ACT A 504 (-3.2A)NoneNoneNoneNone | 1.22A | 2zj0C-5c92A:undetectable | 2zj0C-5c92A:21.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fqd | DNA DAMAGE-BINDINGPROTEIN 1 (Homo sapiens) |
PF03178(CPSF_A)PF10433(MMS1_N) | 5 | THR A1032ASP A1092LEU A 974LEU A1000GLY A1001 | None | 1.37A | 2zj0C-5fqdA:undetectable | 2zj0C-5fqdA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hhl | RETRON-TYPE REVERSETRANSCRIPTASE ([Eubacterium]rectale) |
PF00078(RVT_1) | 5 | ASP A 227GLU A 186LEU A 270GLY A 276HIS A 291 | K A 301 (-3.7A)NoneNoneNoneNone | 1.21A | 2zj0C-5hhlA:undetectable | 2zj0C-5hhlA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hmm | EXODEOXYRIBONUCLEASE (Escherichiavirus T5) |
PF01367(5_3_exonuc)PF02739(5_3_exonuc_N) | 5 | THR A 158ASP A 130GLU A 128LYS A 83ASP A 204 | None MG A 302 ( 2.7A)NoneNone MG A 304 ( 4.5A) | 1.42A | 2zj0C-5hmmA:2.8 | 2zj0C-5hmmA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hmm | EXODEOXYRIBONUCLEASE (Escherichiavirus T5) |
PF01367(5_3_exonuc)PF02739(5_3_exonuc_N) | 5 | THR A 158GLU A 128LYS A 83ASP A 204GLY A 154 | NoneNoneNone MG A 304 ( 4.5A)None | 1.33A | 2zj0C-5hmmA:2.8 | 2zj0C-5hmmA:22.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tov | ADENOSYLHOMOCYSTEINASE (Thermotogamaritima) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | HIS A 123THR A 124ASP A 113LEU A 156LEU A 150 | None | 1.32A | 2zj0C-5tovA:12.1 | 2zj0C-5tovA:35.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5utu | ADENOSYLHOMOCYSTEINASE (Cryptosporidiumparvum) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | ASP A 137GLU A 211LYS A 241ASP A 245LEU A 404HIS A 410 | SAH A 502 (-3.4A)SAH A 502 (-3.8A)SAH A 502 (-2.9A)SAH A 502 (-2.8A)SAH A 502 ( 4.7A)SAH A 502 ( 3.5A) | 1.33A | 2zj0C-5utuA:53.6 | 2zj0C-5utuA:49.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5utu | ADENOSYLHOMOCYSTEINASE (Cryptosporidiumparvum) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 12 | HIS A 53THR A 55ASP A 137GLU A 211LYS A 241ASP A 245LEU A 401LEU A 404GLY A 409HIS A 410MET A 415PHE A 419 | SAH A 502 (-4.0A)SAH A 502 (-2.7A)SAH A 502 (-3.4A)SAH A 502 (-3.8A)SAH A 502 (-2.9A)SAH A 502 (-2.8A)NAD A 501 (-4.1A)SAH A 502 ( 4.7A)SAH A 502 ( 3.7A)SAH A 502 ( 3.5A)SAH A 502 (-3.6A)SAH A 502 (-4.8A) | 0.60A | 2zj0C-5utuA:53.6 | 2zj0C-5utuA:49.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5v96 | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE (Naegleriafowleri) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 12 | HIS A 59THR A 61ASP A 136GLU A 197LYS A 227ASP A 231LEU A 386LEU A 389GLY A 394HIS A 395MET A 400PHE A 404 | ADN A 502 ( 3.9A)ADN A 502 (-2.9A)ADN A 502 (-2.9A)ADN A 502 (-3.5A)ADN A 502 (-2.9A)ADN A 502 (-2.8A)NAD A 501 (-3.9A)ADN A 502 ( 4.7A)ADN A 502 (-3.7A)ADN A 502 ( 3.4A)ADN A 502 (-3.8A)ADN A 502 (-4.9A) | 0.59A | 2zj0C-5v96A:58.5 | 2zj0C-5v96A:58.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w4b | ADENOSYLHOMOCYSTEINASE (Homo sapiens) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 7 | HIS A 55ASP A 131LYS A 186ASP A 190HIS A 353MET A 358PHE A 362 | 9W4 A 502 (-3.7A)NoneNoneNAD A 501 (-4.1A)NAD A 501 (-4.5A)9W4 A 502 (-3.6A)None | 0.90A | 2zj0C-5w4bA:46.3 | 2zj0C-5w4bA:55.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w4b | ADENOSYLHOMOCYSTEINASE (Homo sapiens) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 7 | HIS A 55THR A 57ASP A 131GLU A 156LYS A 186MET A 358PHE A 362 | 9W4 A 502 (-3.7A)9W4 A 502 (-2.9A)NoneNoneNone9W4 A 502 (-3.6A)None | 0.71A | 2zj0C-5w4bA:46.3 | 2zj0C-5w4bA:55.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w4b | ADENOSYLHOMOCYSTEINASE (Homo sapiens) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 7 | HIS A 55THR A 57ASP A 131LYS A 186ASP A 190MET A 358PHE A 362 | 9W4 A 502 (-3.7A)9W4 A 502 (-2.9A)NoneNoneNAD A 501 (-4.1A)9W4 A 502 (-3.6A)None | 0.69A | 2zj0C-5w4bA:46.3 | 2zj0C-5w4bA:55.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w4b | ADENOSYLHOMOCYSTEINASE (Homo sapiens) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | LYS A 186ASP A 190GLY A 352HIS A 353MET A 358PHE A 362 | NoneNAD A 501 (-4.1A)9W4 A 502 ( 3.9A)NAD A 501 (-4.5A)9W4 A 502 (-3.6A)None | 0.97A | 2zj0C-5w4bA:46.3 | 2zj0C-5w4bA:55.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w4b | ADENOSYLHOMOCYSTEINASE (Homo sapiens) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 7 | LYS A 186ASP A 190LEU A 344LEU A 347GLY A 352HIS A 353MET A 358 | NoneNAD A 501 (-4.1A)NAD A 501 (-4.0A)9W4 A 502 (-4.1A)9W4 A 502 ( 3.9A)NAD A 501 (-4.5A)9W4 A 502 (-3.6A) | 1.05A | 2zj0C-5w4bA:46.3 | 2zj0C-5w4bA:55.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w4b | ADENOSYLHOMOCYSTEINASE (Homo sapiens) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | LYS A 186ASP A 190LEU A 347HIS A 353PHE A 362 | NoneNAD A 501 (-4.1A)9W4 A 502 (-4.1A)NAD A 501 (-4.5A)None | 1.32A | 2zj0C-5w4bA:46.3 | 2zj0C-5w4bA:55.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6aph | ADENOSYLHOMOCYSTEINASE (Elizabethkingiaanophelis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 12 | HIS A 58THR A 60ASP A 136GLU A 161LYS A 191ASP A 195LEU A 349LEU A 352GLY A 357HIS A 358MET A 363PHE A 367 | ADN A 501 (-3.9A)ADN A 501 (-2.8A)ADN A 501 (-3.0A)ADN A 501 (-2.5A)ADN A 501 (-2.8A)ADN A 501 (-2.7A)NAD A 500 ( 4.3A)ADN A 501 ( 4.8A)ADN A 501 (-3.6A)ADN A 501 ( 3.5A)ADN A 501 (-3.7A)None | 0.31A | 2zj0C-6aphA:56.0 | 2zj0C-6aphA:54.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bu3 | BETA-LACTAMASE (Escherichiacoli) |
no annotation | 5 | THR A 194ASP A 246LEU A 127LEU A 211GLY A 232 | None | 1.49A | 2zj0C-6bu3A:undetectable | 2zj0C-6bu3A:10.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f3m | - (-) |
no annotation | 6 | ASP B 139GLU B 164LYS B 194ASP B 198LEU B 376HIS B 382 | ZN B 505 ( 2.5A)ADN B 502 (-3.6A)ADN B 502 (-2.8A)ADN B 502 (-2.7A)ADN B 502 ( 4.8A)ADN B 502 (-3.4A) | 1.42A | 2zj0C-6f3mB:51.8 | 2zj0C-6f3mB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f3m | - (-) |
no annotation | 12 | HIS B 61THR B 63ASP B 139GLU B 164LYS B 194ASP B 198LEU B 373LEU B 376GLY B 381HIS B 382MET B 387PHE B 391 | ADN B 502 ( 4.0A)ADN B 502 (-2.8A) ZN B 505 ( 2.5A)ADN B 502 (-3.6A)ADN B 502 (-2.8A)ADN B 502 (-2.7A)NAD B 501 ( 3.9A)ADN B 502 ( 4.8A)ADN B 502 ( 3.7A)ADN B 502 (-3.4A)ADN B 502 (-3.7A)ADN B 502 (-4.9A) | 0.58A | 2zj0C-6f3mB:51.8 | 2zj0C-6f3mB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gbn | - (-) |
no annotation | 6 | ASP A 134GLU A 159LYS A 189ASP A 193LEU A 350HIS A 356 | ADN A 501 (-2.9A)ADN A 501 (-3.9A)ADN A 501 (-2.9A)ADN A 501 (-2.7A)ADN A 501 ( 4.7A)ADN A 501 (-3.4A) | 1.38A | 2zj0C-6gbnA:55.4 | 2zj0C-6gbnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gbn | - (-) |
no annotation | 12 | HIS A 56THR A 58ASP A 134GLU A 159LYS A 189ASP A 193LEU A 347LEU A 350GLY A 355HIS A 356MET A 361PHE A 365 | ADN A 501 (-3.9A)ADN A 501 (-2.8A)ADN A 501 (-2.9A)ADN A 501 (-3.9A)ADN A 501 (-2.9A)ADN A 501 (-2.7A)NAD A 502 (-3.9A)ADN A 501 ( 4.7A)ADN A 501 (-3.8A)ADN A 501 (-3.4A)ADN A 501 (-3.6A)None | 0.57A | 2zj0C-6gbnA:55.4 | 2zj0C-6gbnA:undetectable |