SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZJ0_B_2FAB500_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN


(Equus caballus)
PF00626
(Gelsolin)
4 LEU A  71
GLN A  82
THR A  73
THR A 105
None
1.06A 2zj0B-1d0nA:
undetectable
2zj0B-1d0nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddk IMP-1 METALLO
BETA-LACTAMASE


(Pseudomonas
aeruginosa)
PF00753
(Lactamase_B)
4 GLN A 212
THR A 209
THR A 140
HIS A  77
None
None
None
ZN  A 500 (-3.4A)
1.15A 2zj0B-1ddkA:
3.1
2zj0B-1ddkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN


(Propionibacterium
freudenreichii)
PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
4 LEU A 668
GLN A 643
THR A 640
THR A 683
None
None
None
B12  A 800 ( 4.9A)
1.30A 2zj0B-1e1cA:
4.3
2zj0B-1e1cA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii0 ARSENICAL
PUMP-DRIVING ATPASE


(Escherichia
coli)
PF02374
(ArsA_ATPase)
4 GLN A 430
THR A 480
THR A 451
HIS A 453
None
None
None
CD  A 595 ( 3.5A)
1.33A 2zj0B-1ii0A:
2.4
2zj0B-1ii0A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
4 LEU A 549
GLN A 590
THR A 553
HIS A 545
None
None
None
FE2  A 840 (-3.3A)
1.28A 2zj0B-1loxA:
undetectable
2zj0B-1loxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n11 ANKYRIN

(Homo sapiens)
PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5)
4 LEU A 474
GLN A 471
THR A 472
THR A 518
None
1.29A 2zj0B-1n11A:
undetectable
2zj0B-1n11A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE


(Bos taurus)
PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C)
4 LEU A 873
GLN A 767
THR A 803
THR A1010
TEI  A3006 (-4.8A)
MOS  A3004 (-3.8A)
None
TEI  A3006 (-2.8A)
1.07A 2zj0B-1n5xA:
undetectable
2zj0B-1n5xA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7l TRANSCRIPTIONAL
REGULATOR MODE


(Escherichia
coli)
PF00126
(HTH_1)
PF03459
(TOBE)
4 LEU A 181
GLN A 124
THR A 125
THR A 260
None
1.30A 2zj0B-1o7lA:
undetectable
2zj0B-1o7lA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE


(Fervidobacterium
pennivorans)
PF00082
(Peptidase_S8)
4 LEU A 577
GLN A 618
THR A 619
THR A 572
None
1.34A 2zj0B-1r6vA:
2.9
2zj0B-1r6vA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rgi GELSOLIN

(Equus caballus)
PF00626
(Gelsolin)
4 LEU G  71
GLN G  82
THR G  73
THR G 105
None
1.05A 2zj0B-1rgiG:
undetectable
2zj0B-1rgiG:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t44 CHIMERA OF GELSOLIN
DOMAIN 1 AND
C-TERMINAL DOMAIN OF
THYMOSIN BETA-4


(Homo sapiens;
Mus musculus)
PF00626
(Gelsolin)
PF01290
(Thymosin)
4 LEU G  71
GLN G  82
THR G  73
THR G 105
None
1.05A 2zj0B-1t44G:
undetectable
2zj0B-1t44G:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xea OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY


(Vibrio cholerae)
PF01408
(GFO_IDH_MocA)
4 LEU A 144
GLN A 205
THR A 209
THR A 227
None
1.25A 2zj0B-1xeaA:
6.1
2zj0B-1xeaA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt3 RIBONUCLEASE D

(Escherichia
coli)
PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1)
4 LEU A 290
GLN A 213
THR A 211
THR A 284
None
1.24A 2zj0B-1yt3A:
undetectable
2zj0B-1yt3A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1


(Homo sapiens)
PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth)
4 LEU A  22
GLN A  64
THR A  65
THR A  27
None
1.12A 2zj0B-2c4kA:
2.7
2zj0B-2c4kA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ff6 GELSOLIN

(Homo sapiens)
PF00626
(Gelsolin)
4 LEU G  71
GLN G  82
THR G  73
THR G 105
None
1.04A 2zj0B-2ff6G:
undetectable
2zj0B-2ff6G:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ice COMPLEMENT C3 BETA
CHAIN


(Homo sapiens)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
4 GLN A 631
THR A 632
THR A 514
HIS A  25
None
0.97A 2zj0B-2iceA:
undetectable
2zj0B-2iceA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbb TALIN-1

(Mus musculus)
no annotation 4 LEU A1741
GLN A1764
THR A1765
THR A1704
None
1.01A 2zj0B-2kbbA:
undetectable
2zj0B-2kbbA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlz CEPHALOSPORIN
ACYLASE


(Bacillus
halodurans)
PF01019
(G_glu_transpept)
4 LEU A 208
GLN A 375
THR A  56
THR A 390
None
1.06A 2zj0B-2nlzA:
undetectable
2zj0B-2nlzA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN


(Porphyromonas
gingivalis)
PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C)
4 GLN A 333
THR A 107
THR A 383
HIS A 414
GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
0.99A 2zj0B-2nvvA:
2.2
2zj0B-2nvvA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o26 MAST/STEM CELL
GROWTH FACTOR
RECEPTOR


(Mus musculus)
no annotation 4 GLN X 275
THR X 277
THR X 306
HIS X 222
None
1.34A 2zj0B-2o26X:
undetectable
2zj0B-2o26X:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN


(Bacteroides
thetaiotaomicron)
PF02384
(N6_Mtase)
PF12161
(HsdM_N)
4 LEU A  18
GLN A  25
THR A  21
THR A 115
None
1.30A 2zj0B-2okcA:
4.4
2zj0B-2okcA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2om6 PROBABLE
PHOSPHOSERINE
PHOSPHATASE


(Pyrococcus
horikoshii)
PF13419
(HAD_2)
4 LEU A  15
THR A 104
THR A   8
HIS A 180
None
1.01A 2zj0B-2om6A:
3.5
2zj0B-2om6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p14 HETERODIMERIC
RESTRICTION
ENDONUCLEASE
R.BSPD6I SMALL
SUBUNIT


(Bacillus sp. D6)
PF09491
(RE_AlwI)
4 LEU A   5
GLN A 144
THR A 143
THR A  25
None
1.15A 2zj0B-2p14A:
3.0
2zj0B-2p14A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE


(Escherichia
coli)
PF02618
(YceG)
4 LEU A 137
GLN A 147
THR A 144
THR A 173
None
1.11A 2zj0B-2r1fA:
undetectable
2zj0B-2r1fA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wlv GAG POLYPROTEIN

(Human
immunodeficiency
virus 2)
PF00607
(Gag_p24)
4 LEU B  14
THR B  18
THR B  47
HIS B  11
None
1.20A 2zj0B-2wlvB:
undetectable
2zj0B-2wlvB:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN


(Escherichia
coli)
PF02384
(N6_Mtase)
PF12161
(HsdM_N)
4 LEU B 163
GLN B 166
THR B 358
HIS B 335
None
1.25A 2zj0B-2y7cB:
3.9
2zj0B-2y7cB:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yet GH61 ISOZYME A

(Thermoascus
aurantiacus)
PF03443
(Glyco_hydro_61)
4 LEU A  41
GLN A   5
THR A  36
HIS A  57
HIC  A   1 ( 4.9A)
None
None
None
1.30A 2zj0B-2yetA:
undetectable
2zj0B-2yetA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypf AVRBS3

(Xanthomonas
campestris)
PF03377
(TAL_effector)
4 LEU A 545
GLN A 515
THR A 513
HIS A 525
None
1.11A 2zj0B-2ypfA:
undetectable
2zj0B-2ypfA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypf AVRBS3

(Xanthomonas
campestris)
PF03377
(TAL_effector)
4 LEU A 647
GLN A 617
THR A 615
HIS A 627
None
1.27A 2zj0B-2ypfA:
undetectable
2zj0B-2ypfA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq3 DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1


(Saccharomyces
cerevisiae)
PF03556
(Cullin_binding)
PF14555
(UBA_4)
4 LEU A 116
GLN A 137
THR A 133
THR A 109
None
1.20A 2zj0B-3bq3A:
undetectable
2zj0B-3bq3A:
18.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ce6 ADENOSYLHOMOCYSTEINA
SE


(Mycobacterium
tuberculosis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 LEU A  68
GLN A  73
THR A  74
THR A 219
HIS A 363
None
ADN  A 500 (-3.6A)
ADN  A 500 (-4.5A)
NAD  A 550 ( 2.8A)
ADN  A 500 ( 3.7A)
0.29A 2zj0B-3ce6A:
66.7
2zj0B-3ce6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjp PREDICTED
AMIDOHYDROLASE,
DIHYDROOROTASE
FAMILY


(Clostridium
acetobutylicum)
PF04909
(Amidohydro_2)
4 LEU A  32
THR A  30
THR A  35
HIS A  38
None
1.32A 2zj0B-3cjpA:
undetectable
2zj0B-3cjpA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db2 PUTATIVE
NADPH-DEPENDENT
OXIDOREDUCTASE


(Desulfitobacterium
hafniense)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 LEU A 178
GLN A 217
THR A 232
HIS A 341
None
1.19A 2zj0B-3db2A:
2.6
2zj0B-3db2A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbo UNCHARACTERIZED
PROTEIN


(Mycobacterium
tuberculosis)
PF01850
(PIN)
PF02604
(PhdYeFM_antitox)
4 LEU B  58
GLN A  69
THR B  77
THR B  51
None
None
None
NA  B 301 (-2.8A)
1.28A 2zj0B-3dboB:
undetectable
2zj0B-3dboB:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed0 (3R)-HYDROXYMYRISTOY
L-ACYL CARRIER
PROTEIN DEHYDRATASE


(Helicobacter
pylori)
PF07977
(FabA)
4 LEU A 119
GLN A  76
THR A 138
HIS A 122
None
1.28A 2zj0B-3ed0A:
undetectable
2zj0B-3ed0A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN


(Streptococcus
agalactiae)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
4 LEU A 946
GLN A1036
THR A1035
THR A 922
None
None
None
CL  A1223 (-4.3A)
1.33A 2zj0B-3fawA:
undetectable
2zj0B-3fawA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd5 SELENIDE, WATER
DIKINASE 1


(Homo sapiens)
PF00586
(AIRS)
PF02769
(AIRS_C)
4 LEU A 324
THR A 200
THR A 117
HIS A 256
None
1.28A 2zj0B-3fd5A:
undetectable
2zj0B-3fd5A:
22.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g1u ADENOSYLHOMOCYSTEINA
SE


(Leishmania
major)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 LEU A  51
GLN A  56
THR A  57
THR A 156
HIS A 300
None
ADN  A 438 (-3.8A)
ADN  A 438 (-4.6A)
NAD  A 439 ( 3.0A)
ADN  A 438 ( 4.0A)
0.34A 2zj0B-3g1uA:
53.5
2zj0B-3g1uA:
54.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gem SHORT CHAIN
DEHYDROGENASE


(Pseudomonas
savastanoi)
PF13561
(adh_short_C2)
4 LEU A  78
THR A  75
THR A  11
HIS A  83
None
1.31A 2zj0B-3gemA:
7.6
2zj0B-3gemA:
17.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glq ADENOSYLHOMOCYSTEINA
SE


(Burkholderia
pseudomallei)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 LEU A  61
GLN A  66
THR A  67
THR A 200
HIS A 344
None
RAB  A 602 (-3.9A)
RAB  A 602 (-4.5A)
NAD  A 601 ( 2.9A)
RAB  A 602 ( 3.5A)
0.34A 2zj0B-3glqA:
58.7
2zj0B-3glqA:
57.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwj ARYLPHORIN

(Antheraea
pernyi)
PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C)
4 LEU A 290
GLN A 404
THR A 405
THR A 161
None
1.09A 2zj0B-3gwjA:
undetectable
2zj0B-3gwjA:
21.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h9u ADENOSYLHOMOCYSTEINA
SE


(Trypanosoma
brucei)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 LEU A  51
GLN A  56
THR A  57
THR A 156
HIS A 300
None
ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
0.51A 2zj0B-3h9uA:
55.6
2zj0B-3h9uA:
56.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3


(Enterococcus
faecalis)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
4 LEU A 301
THR A  14
THR A 324
HIS A 178
None
CSO  A  13 ( 3.6A)
None
None
1.31A 2zj0B-3il4A:
2.1
2zj0B-3il4A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11


(Schizosaccharomyces
pombe)
PF13087
(AAA_12)
PF16399
(Aquarius_N)
4 LEU X 690
THR X 692
THR X 701
HIS X 716
None
1.28A 2zj0B-3jb9X:
undetectable
2zj0B-3jb9X:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfu DNA HELICASE II

(Escherichia
coli)
PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
4 LEU A 512
GLN A 480
THR A 481
HIS A 537
None
1.22A 2zj0B-3lfuA:
undetectable
2zj0B-3lfuA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6i L-ARABINITOL
4-DEHYDROGENASE


(Neurospora
crassa)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 LEU A 137
THR A  50
THR A  14
HIS A  74
None
1.25A 2zj0B-3m6iA:
9.9
2zj0B-3m6iA:
22.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n58 ADENOSYLHOMOCYSTEINA
SE


(Brucella
abortus)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 LEU A  54
GLN A  59
THR A  60
THR A 193
HIS A 337
None
K  A   2 ( 3.3A)
ADN  A 500 (-4.6A)
NAD  A 550 ( 3.0A)
ADN  A 500 ( 3.6A)
0.42A 2zj0B-3n58A:
58.7
2zj0B-3n58A:
60.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6b DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1


(Saccharomyces
cerevisiae)
PF03556
(Cullin_binding)
4 LEU A 116
GLN A 137
THR A 133
THR A 109
None
1.26A 2zj0B-3o6bA:
undetectable
2zj0B-3o6bA:
16.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3one ADENOSYLHOMOCYSTEINA
SE


(Lupinus luteus)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 LEU A  61
GLN A  66
THR A  67
THR A 206
HIS A 350
None
ADE  A 506 (-3.8A)
ADE  A 506 (-4.5A)
NAD  A 501 (-2.8A)
None
0.68A 2zj0B-3oneA:
58.1
2zj0B-3oneA:
59.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae)
PF00194
(Carb_anhydrase)
4 LEU A 234
GLN A 237
THR A 235
THR A 126
None
1.32A 2zj0B-3q31A:
undetectable
2zj0B-3q31A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr5 CARDIAC CA2+ RELEASE
CHANNEL


(Mus musculus)
PF08709
(Ins145_P3_rec)
4 GLN A  33
THR A  27
THR A 210
HIS A 193
None
1.19A 2zj0B-3qr5A:
undetectable
2zj0B-3qr5A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tu5 GELSOLIN,PROTEIN
CORDON-BLEU,THYMOSIN
BETA-4


(Homo sapiens;
Mus musculus)
PF00626
(Gelsolin)
4 LEU B  47
GLN B  58
THR B  49
THR B  81
None
1.01A 2zj0B-3tu5B:
undetectable
2zj0B-3tu5B:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugm TAL EFFECTOR
AVRBS3/PTHA


(Xanthomonas
oryzae)
PF03377
(TAL_effector)
4 LEU A 612
GLN A 582
THR A 580
HIS A 592
None
1.03A 2zj0B-3ugmA:
undetectable
2zj0B-3ugmA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugm TAL EFFECTOR
AVRBS3/PTHA


(Xanthomonas
oryzae)
PF03377
(TAL_effector)
4 LEU A 612
GLN A 583
THR A 580
HIS A 592
None
1.14A 2zj0B-3ugmA:
undetectable
2zj0B-3ugmA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugm TAL EFFECTOR
AVRBS3/PTHA


(Xanthomonas
oryzae)
PF03377
(TAL_effector)
4 LEU A 884
GLN A 854
THR A 852
HIS A 864
None
1.17A 2zj0B-3ugmA:
undetectable
2zj0B-3ugmA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmn DEXTRANASE

(Streptococcus
mutans)
PF13199
(Glyco_hydro_66)
4 LEU A 638
GLN A 602
THR A 603
THR A 635
None
0.85A 2zj0B-3vmnA:
undetectable
2zj0B-3vmnA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkm PYRIDOXAL PHOSPHATE
PHOSPHATASE,
PHOSPHOGLYCOLATE
PHOSPHATASE,
PYRIDOXAL PHOSPHATE
PHOSPHATASE


(Mus musculus)
PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6)
4 LEU A 249
GLN A 277
THR A 263
HIS A 257
None
1.34A 2zj0B-4bkmA:
2.3
2zj0B-4bkmA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
ALPHA
F420-REDUCING
HYDROGENASE, SUBUNIT
GAMMA


(Methanothermobacter
marburgensis)
PF00037
(Fer4)
PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
4 LEU A 381
THR A 351
THR B  86
HIS B  53
None
1.24A 2zj0B-4ci0A:
undetectable
2zj0B-4ci0A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnk L-AMINO ACID OXIDASE

(Streptococcus
cristatus)
PF03486
(HI0933_like)
4 GLN A 156
THR A   6
THR A 348
HIS A 389
None
1.17A 2zj0B-4cnkA:
2.3
2zj0B-4cnkA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czw PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2


(Neurospora
crassa)
PF00929
(RNase_T)
PF13423
(UCH_1)
4 LEU A 531
THR A 986
THR A 528
HIS A 525
None
None
None
ZN  A3094 (-3.1A)
1.17A 2zj0B-4czwA:
undetectable
2zj0B-4czwA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8u D-CYSTEINE
DESULFHYDRASE


(Salmonella
enterica)
PF00291
(PALP)
4 LEU A 321
GLN A  77
THR A 288
HIS A 314
None
None
LLP  A  51 ( 4.5A)
None
1.19A 2zj0B-4d8uA:
3.2
2zj0B-4d8uA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU


(Yersinia
enterocolitica)
PF01408
(GFO_IDH_MocA)
4 LEU A 168
GLN A 331
THR A 179
HIS A 322
None
1.03A 2zj0B-4gmfA:
2.9
2zj0B-4gmfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h63 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17


(Schizosaccharomyces
pombe)
PF10156
(Med17)
4 LEU Q 347
GLN Q 263
THR Q 349
HIS Q 394
None
1.05A 2zj0B-4h63Q:
undetectable
2zj0B-4h63Q:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htw GAG PROTEIN

(Simian
immunodeficiency
virus)
PF00607
(Gag_p24)
4 LEU A  14
THR A  18
THR A  47
HIS A  11
None
1.20A 2zj0B-4htwA:
undetectable
2zj0B-4htwA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2


(Homo sapiens)
PF00415
(RCC1)
4 LEU A 600
GLN A 625
THR A 621
THR A 647
None
None
None
SO4  A 802 (-3.5A)
0.99A 2zj0B-4l1mA:
undetectable
2zj0B-4l1mA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE


(Vibrio cholerae)
PF01135
(PCMT)
4 LEU A  24
GLN A  16
THR A  14
THR A  68
None
1.34A 2zj0B-4l7vA:
3.5
2zj0B-4l7vA:
19.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)


(Bradyrhizobium
elkanii)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 LEU A  57
GLN A  62
THR A  63
THR A 198
HIS A 342
None
NH4  A 502 ( 3.1A)
ADN  A 501 (-4.5A)
NAD  A 503 ( 2.9A)
ADN  A 501 ( 3.7A)
0.31A 2zj0B-4lvcA:
59.3
2zj0B-4lvcA:
58.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maa PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN


(Pseudomonas
protegens)
PF13458
(Peripla_BP_6)
4 LEU A 292
GLN A 297
THR A 296
THR A 286
None
1.32A 2zj0B-4maaA:
5.5
2zj0B-4maaA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq1 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE


(Legionella
pneumophila)
PF00701
(DHDPS)
4 GLN A 111
THR A 110
THR A  81
HIS A 120
None
None
MRD  A 301 ( 4.2A)
MRD  A 301 ( 4.8A)
1.28A 2zj0B-4nq1A:
undetectable
2zj0B-4nq1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pkh GELSOLIN,TROPOMODULI
N-1 CHIMERA


(Homo sapiens)
PF00626
(Gelsolin)
PF03250
(Tropomodulin)
4 LEU B  98
GLN B 109
THR B 100
THR B 132
None
1.06A 2zj0B-4pkhB:
undetectable
2zj0B-4pkhB:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pki GELSOLIN,TROPOMODULI
N-1 CHIMERA


(Homo sapiens)
PF00626
(Gelsolin)
4 LEU G  98
GLN G 109
THR G 100
THR G 132
None
1.06A 2zj0B-4pkiG:
undetectable
2zj0B-4pkiG:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE


(Chlamydia
trachomatis)
PF00595
(PDZ)
PF03572
(Peptidase_S41)
4 GLN A 477
THR A 478
THR A 483
HIS A 231
None
1.26A 2zj0B-4ql6A:
undetectable
2zj0B-4ql6A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlb PROBABLE GLYCOGEN
[STARCH] SYNTHASE


(Caenorhabditis
elegans)
PF05693
(Glycogen_syn)
4 LEU A 214
GLN A 153
THR A 218
HIS A 271
None
1.31A 2zj0B-4qlbA:
2.1
2zj0B-4qlbA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubq BETA-LACTAMASE

(Acinetobacter
baumannii)
no annotation 4 GLN A 213
THR A 210
THR A 141
HIS A  78
None
None
None
ZN  A 301 (-3.4A)
1.25A 2zj0B-4ubqA:
3.2
2zj0B-4ubqA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4j PUTATIVE OXYGENASE

(Amycolatopsis
orientalis)
PF01494
(FAD_binding_3)
4 LEU A 330
GLN A 286
THR A 333
HIS A 323
None
1.11A 2zj0B-4x4jA:
3.1
2zj0B-4x4jA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA


(Homo sapiens)
PF00626
(Gelsolin)
4 LEU G  47
GLN G  58
THR G  49
THR G  81
None
1.02A 2zj0B-4z94G:
undetectable
2zj0B-4z94G:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9h METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
II


(Escherichia
coli)
PF02203
(TarH)
4 LEU A 137
GLN A 155
THR A 154
THR A 146
None
1.34A 2zj0B-4z9hA:
undetectable
2zj0B-4z9hA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zjg ALPHA-2-MACROGLOBULI
N


(Escherichia
coli)
PF11974
(MG1)
4 LEU A 344
GLN A 333
THR A 332
HIS A 341
None
None
None
PGE  A 402 (-4.2A)
1.08A 2zj0B-4zjgA:
undetectable
2zj0B-4zjgA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrq TRANSCOBALAMIN-2

(Homo sapiens)
PF01122
(Cobalamin_bind)
PF14478
(DUF4430)
4 LEU A 260
GLN A 266
THR A 228
HIS A 221
None
1.20A 2zj0B-4zrqA:
undetectable
2zj0B-4zrqA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6u AMINOTRANSFERASE

(Mycobacterium
tuberculosis)
PF12897
(Aminotran_MocR)
4 LEU A   6
GLN A   9
THR A 419
HIS A  18
None
1.34A 2zj0B-5c6uA:
2.7
2zj0B-5c6uA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT


(Azospira oryzae)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
4 LEU A 554
GLN A 547
THR A 486
HIS A 162
None
1.16A 2zj0B-5chcA:
3.1
2zj0B-5chcA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9p ANTHRONE
OXIDASE-LIKE PROTEIN


(Streptomyces
ambofaciens)
PF03992
(ABM)
4 LEU A 162
GLN A  63
THR A  12
HIS A 159
None
None
None
GOL  A 301 (-3.5A)
1.08A 2zj0B-5f9pA:
undetectable
2zj0B-5f9pA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44


(Homo sapiens)
PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6)
4 LEU A 235
GLN A 257
THR A 264
HIS A 323
None
1.33A 2zj0B-5gu6A:
undetectable
2zj0B-5gu6A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ibv CAPSID POLYPROTEIN
VP90


(Mamastrovirus 1)
PF03115
(Astro_capsid_N)
4 LEU A 112
GLN A 406
THR A 405
THR A 209
None
1.10A 2zj0B-5ibvA:
undetectable
2zj0B-5ibvA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ibv CAPSID POLYPROTEIN
VP90


(Mamastrovirus 1)
PF03115
(Astro_capsid_N)
4 LEU A 112
GLN A 406
THR A 405
THR A 218
None
1.28A 2zj0B-5ibvA:
undetectable
2zj0B-5ibvA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1


(Kribbella
flavida)
PF13416
(SBP_bac_8)
4 LEU A 318
GLN A 342
THR A 338
THR A  51
None
1.21A 2zj0B-5ixpA:
undetectable
2zj0B-5ixpA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwr CIRCADIAN CLOCK
PROTEIN KAIA


(Thermosynechococcus
elongatus)
PF07688
(KaiA)
4 LEU E 239
GLN E 246
THR E 242
THR E 199
None
1.34A 2zj0B-5jwrE:
undetectable
2zj0B-5jwrE:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L38,
MITOCHONDRIAL


(Homo sapiens)
PF01161
(PBP)
4 LEU 6 236
GLN 6 275
THR 6 238
THR 6 300
None
1.28A 2zj0B-5ool6:
undetectable
2zj0B-5ool6:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osh VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29


(Homo sapiens)
no annotation 4 LEU A   9
THR A 136
THR A  37
HIS A  86
None
1.24A 2zj0B-5oshA:
undetectable
2zj0B-5oshA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veu CYTOCHROME P450 3A5

(Homo sapiens)
no annotation 4 LEU A 490
GLN A 471
THR A 470
THR A 317
None
1.20A 2zj0B-5veuA:
undetectable
2zj0B-5veuA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)


(Helicobacter
pylori)
no annotation 4 LEU A 131
GLN A 138
THR A 136
THR A 116
None
1.23A 2zj0B-5wbfA:
undetectable
2zj0B-5wbfA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjg VACUOLAR PROTEIN 8

(Saccharomyces
cerevisiae)
PF00514
(Arm)
4 LEU A 259
GLN A 270
THR A 229
HIS A 296
None
None
None
PE5  A 601 (-4.1A)
1.23A 2zj0B-5xjgA:
undetectable
2zj0B-5xjgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt CORE PROTEIN VP6

(Aquareovirus C)
no annotation 4 LEU U 296
GLN U 288
THR U 291
THR U 316
None
1.23A 2zj0B-5zvtU:
undetectable
2zj0B-5zvtU:
10.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6aph ADENOSYLHOMOCYSTEINA
SE


(Elizabethkingia
anophelis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 LEU A  57
GLN A  62
THR A  63
THR A 162
HIS A 306
None
ADN  A 501 (-3.8A)
ADN  A 501 (-4.5A)
NAD  A 500 ( 2.9A)
ADN  A 501 ( 3.7A)
0.36A 2zj0B-6aphA:
56.0
2zj0B-6aphA:
54.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b20 GUANINE
NUCLEOTIDE-BINDING
PROTEIN
G(I)/G(S)/G(T)
SUBUNIT BETA-1


(Bos taurus)
no annotation 4 LEU A  51
THR A  87
THR A 329
HIS A 311
None
1.24A 2zj0B-6b20A:
undetectable
2zj0B-6b20A:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnl NKT VALPHA14 (MOUSE)
- 2C12 TCR - HYBRID
MOUSE VARIABLE AND
HUMAN CONSTANT
DOMAINS


(Homo sapiens)
no annotation 4 LEU C  20
GLN C 111
THR C 110
THR C  80
None
0.94A 2zj0B-6bnlC:
undetectable
2zj0B-6bnlC:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3


(Homo sapiens)
no annotation 4 GLN A 466
THR A 378
THR A 203
HIS A 373
None
None
None
ZN  A 902 (-3.3A)
1.11A 2zj0B-6c01A:
undetectable
2zj0B-6c01A:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-)
no annotation 4 GLN A 466
THR A 379
THR A 204
HIS A 374
None
None
None
ZN  A1002 (-3.1A)
1.13A 2zj0B-6f2tA:
undetectable
2zj0B-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-)
no annotation 4 GLN B  65
THR B  66
THR B 165
HIS B 323
K  B 504 ( 3.0A)
ADN  B 502 (-4.6A)
NAD  B 501 ( 2.8A)
ZN  B 505 (-3.2A)
0.23A 2zj0B-6f3mB:
51.9
2zj0B-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-)
no annotation 5 LEU A  55
GLN A  60
THR A  61
THR A 160
HIS A 304
None
NA  A 503 ( 3.2A)
ADN  A 501 (-4.6A)
NAD  A 502 ( 2.8A)
ADN  A 501 ( 3.6A)
0.32A 2zj0B-6gbnA:
55.5
2zj0B-6gbnA:
undetectable