SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZJ0_A_2FAA500_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amy 1,4-ALPHA-D-GLUCAN
GLUCANOHYDROLASE

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		4 THR A 290
THR A 207
HIS A 224
LEU A 228
 None
 1.37A 2zj0A-1amyA:
undetectable		 2zj0A-1amyA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddk IMP-1 METALLO
BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 GLN A 212
THR A 209
THR A 140
HIS A  77
 None
None
None
ZN  A 500 (-3.4A)
 1.18A 2zj0A-1ddkA:
2.5		 2zj0A-1ddkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 GLN B 210
THR B 173
THR B 492
LEU B 507
 None
 1.37A 2zj0A-1e9yB:
undetectable		 2zj0A-1e9yB:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iie PROTEIN (HLA-DR
ANTIGENS ASSOCIATED
INVARIANT CHAIN)

(Homo sapiens) 		PF08831
(MHCassoc_trimer) 		4 GLN A 131
THR A 156
HIS A 152
LEU A 142
 None
 1.25A 2zj0A-1iieA:
undetectable		 2zj0A-1iieA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbl PYRUVATE PHOSPHATE
DIKINASE

([Clostridium]
symbiosum) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 GLN A 293
THR A 292
THR A 453
LEU A 396
 None
 1.35A 2zj0A-1kblA:
2.2		 2zj0A-1kblA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwh 4-ALPHA-GLUCANOTRANS
FERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09178
(DUF1945) 		4 THR A 239
THR A 303
HIS A 419
LEU A 296
 None
 1.34A 2zj0A-1lwhA:
undetectable		 2zj0A-1lwhA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 GLN A 319
THR A 334
HIS A 380
LEU A 403
 None
P16  A   2 (-3.7A)
None
None
 1.39A 2zj0A-1opkA:
undetectable		 2zj0A-1opkA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN

(Salmonella
enterica) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N) 		4 GLN A 158
THR A 161
THR A 110
LEU A 103
 None
 1.24A 2zj0A-1pemA:
undetectable		 2zj0A-1pemA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 GLN E 278
THR E 280
HIS E 119
LEU E 230
 None
 1.34A 2zj0A-1skyE:
undetectable		 2zj0A-1skyE:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tht THIOESTERASE

(Vibrio harveyi) 		PF02273
(Acyl_transf_2) 		4 GLN A 101
THR A 105
HIS A  10
LEU A  12
 None
 1.39A 2zj0A-1thtA:
6.5		 2zj0A-1thtA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujj ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA1

(Homo sapiens) 		PF00790
(VHS) 		4 GLN A  36
THR A   9
THR A  18
LEU A  51
 None
 1.20A 2zj0A-1ujjA:
undetectable		 2zj0A-1ujjA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uun MSPA

(Mycolicibacterium
smegmatis) 		PF09203
(MspA) 		4 THR A 176
THR A 130
HIS A  42
LEU A  25
 None
 1.29A 2zj0A-1uunA:
undetectable		 2zj0A-1uunA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvi PUTATIVE
PHOSPHATASES
INVOLVED IN
N-ACETYL-GLUCOSAMINE
CATABOLISM

(Streptococcus
mutans) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 GLN A1053
THR A1064
THR A1042
LEU A1074
 None
 1.30A 2zj0A-1wviA:
undetectable		 2zj0A-1wviA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a81 CARB

(Pectobacterium
carotovorum) 		PF00378
(ECH_1) 		4 GLN A 220
THR A 221
THR A 148
LEU A  91
 None
 1.18A 2zj0A-2a81A:
undetectable		 2zj0A-2a81A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		4 GLN A 362
THR A 334
THR A 399
LEU A 376
 None
None
None
COA  A2600 (-4.9A)
 1.35A 2zj0A-2ahwA:
2.1		 2zj0A-2ahwA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvt RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE CHAIN 1

(Saccharomyces
cerevisiae) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 THR A 608
THR A 204
HIS A 200
LEU A 481
 None
 1.14A 2zj0A-2cvtA:
undetectable		 2zj0A-2cvtA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpw GREEN FLUORESCENT
PROTEIN

(Clytia gregaria) 		PF01353
(GFP) 		4 GLN A  89
THR A  88
HIS A 200
LEU A 202
 None
 1.02A 2zj0A-2hpwA:
undetectable		 2zj0A-2hpwA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLN A 300
THR A 315
HIS A 361
LEU A 354
 None
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
GIN  A 600 ( 4.6A)
 1.23A 2zj0A-2hz0A:
undetectable		 2zj0A-2hz0A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.09A 2zj0A-2nvvA:
2.5		 2zj0A-2nvvA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o26 MAST/STEM CELL
GROWTH FACTOR
RECEPTOR

(Mus musculus) 		no annotation 4 GLN X 275
THR X 277
THR X 306
HIS X 222
 None
 1.27A 2zj0A-2o26X:
undetectable		 2zj0A-2o26X:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8e DNA MISMATCH REPAIR
PROTEIN MSH6

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 THR B 750
THR B1142
HIS B1096
LEU B1149
 None
 1.31A 2zj0A-2o8eB:
undetectable		 2zj0A-2o8eB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzu PUTATIVE SULFATASE
YIDJ

(Bacteroides
fragilis) 		PF00884
(Sulfatase) 		4 GLN A 380
THR A 378
HIS A 164
LEU A 109
 None
 1.10A 2zj0A-2qzuA:
undetectable		 2zj0A-2qzuA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLN B 232
THR B 516
HIS B 483
LEU B 492
 HPA  B1780 ( 3.1A)
None
None
XAX  B1778 (-3.9A)
 1.24A 2zj0A-2w55B:
undetectable		 2zj0A-2w55B:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLN A 330
THR A 477
HIS A 339
LEU A 338
 None
 1.31A 2zj0A-2xk9A:
undetectable		 2zj0A-2xk9A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yia RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		4 THR A 733
THR A 411
HIS A 414
LEU A 482
 None
 1.35A 2zj0A-2yiaA:
undetectable		 2zj0A-2yiaA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzg ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 GLN A 575
THR A 720
HIS A 613
LEU A 638
 None
None
ZN  A 901 (-3.5A)
None
 1.22A 2zj0A-2zzgA:
undetectable		 2zj0A-2zzgA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brz TODX

(Pseudomonas
putida) 		PF03349
(Toluene_X) 		4 THR A   1
THR A  55
HIS A 420
LEU A 374
 None
 1.39A 2zj0A-3brzA:
undetectable		 2zj0A-3brzA:
22.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 GLN A  73
THR A  74
THR A 219
HIS A 363
LEU A 407
 ADN  A 500 (-3.6A)
ADN  A 500 (-4.5A)
NAD  A 550 ( 2.8A)
ADN  A 500 ( 3.7A)
NAD  A 550 (-4.2A)
 0.21A 2zj0A-3ce6A:
66.8		 2zj0A-3ce6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cl3 ORF K13

(Human
gammaherpesvirus
8) 		PF01335
(DED) 		4 THR A  52
THR A  87
HIS A  83
LEU A  80
 None
 1.39A 2zj0A-3cl3A:
undetectable		 2zj0A-3cl3A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeg 2-ISOPROPYLMALATE
SYNTHASE

(Cytophaga
hutchinsonii) 		PF00682
(HMGL-like) 		4 THR A 211
THR A 259
HIS A 263
LEU A 266
 None
 1.08A 2zj0A-3eegA:
undetectable		 2zj0A-3eegA:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g1u ADENOSYLHOMOCYSTEINA
SE

(Leishmania
major) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 GLN A  56
THR A  57
THR A 156
HIS A 300
LEU A 343
 ADN  A 438 (-3.8A)
ADN  A 438 (-4.6A)
NAD  A 439 ( 3.0A)
ADN  A 438 ( 4.0A)
NAD  A 439 ( 4.0A)
 0.33A 2zj0A-3g1uA:
53.4		 2zj0A-3g1uA:
54.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 GLN A  66
THR A  67
THR A 200
HIS A 344
LEU A 385
 RAB  A 602 (-3.9A)
RAB  A 602 (-4.5A)
NAD  A 601 ( 2.9A)
RAB  A 602 ( 3.5A)
NAD  A 601 ( 4.1A)
 0.30A 2zj0A-3glqA:
58.7		 2zj0A-3glqA:
57.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 GLN A  56
THR A  57
THR A 156
HIS A 300
LEU A 343
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
NAD  A 438 (-4.0A)
 0.58A 2zj0A-3h9uA:
55.5		 2zj0A-3h9uA:
56.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Rhodospirillum
rubrum) 		PF13458
(Peripla_BP_6) 		4 GLN A 335
THR A 337
THR A 294
LEU A 287
 None
 1.30A 2zj0A-3i45A:
5.0		 2zj0A-3i45A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE

(Aspergillus
fumigatus) 		PF11991
(Trp_DMAT) 		4 GLN A 343
THR A 348
HIS A 396
LEU A 360
 DST  A 460 (-3.1A)
None
None
None
 1.20A 2zj0A-3i4xA:
undetectable		 2zj0A-3i4xA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip1 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLN A  74
THR A  75
THR A  87
LEU A  93
 None
 1.28A 2zj0A-3ip1A:
10.2		 2zj0A-3ip1A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jts MHC CLASS I
MAMU-A*02

(Macaca mulatta) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 GLN A 218
THR A 216
THR A 187
LEU A 266
 None
 1.38A 2zj0A-3jtsA:
undetectable		 2zj0A-3jtsA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mr1 METHIONINE
AMINOPEPTIDASE

(Rickettsia
prowazekii) 		PF00557
(Peptidase_M24) 		4 THR A  28
THR A 106
HIS A 234
LEU A 248
 None
 1.16A 2zj0A-3mr1A:
undetectable		 2zj0A-3mr1A:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n58 ADENOSYLHOMOCYSTEINA
SE

(Brucella
abortus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 GLN A  59
THR A  60
THR A 193
HIS A 337
LEU A 378
 K  A   2 ( 3.3A)
ADN  A 500 (-4.6A)
NAD  A 550 ( 3.0A)
ADN  A 500 ( 3.6A)
NAD  A 550 (-4.3A)
 0.32A 2zj0A-3n58A:
58.6		 2zj0A-3n58A:
60.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5b ASR0485 PROTEIN

(Nostoc sp. PCC
7120) 		PF12058
(DUF3539) 		4 GLN B  37
THR B  14
HIS B  12
LEU B  18
 None
 1.40A 2zj0A-3n5bB:
undetectable		 2zj0A-3n5bB:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o9p PERIPLASMIC MUREIN
PEPTIDE-BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 THR A 316
THR A 429
HIS A 432
LEU A 115
 None
 1.33A 2zj0A-3o9pA:
undetectable		 2zj0A-3o9pA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaa ATP SYNTHASE SUBUNIT
BETA

(Escherichia
coli) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 GLN D 268
THR D 270
HIS D 110
LEU D 221
 None
 1.31A 2zj0A-3oaaD:
2.1		 2zj0A-3oaaD:
23.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 GLN A  66
THR A  67
THR A 206
HIS A 350
LEU A 395
 ADE  A 506 (-3.8A)
ADE  A 506 (-4.5A)
NAD  A 501 (-2.8A)
None
NAD  A 501 (-4.2A)
 0.46A 2zj0A-3oneA:
58.2		 2zj0A-3oneA:
59.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aspergillus
nidulans) 		PF01179
(Cu_amine_oxid)
PF09248
(DUF1965) 		4 GLN A 618
THR A 617
THR A 644
LEU A 712
 None
 1.36A 2zj0A-3pgbA:
undetectable		 2zj0A-3pgbA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)

(Mycobacterium
tuberculosis) 		PF00857
(Isochorismatase) 		4 GLN A 141
THR A 142
THR A 160
LEU A 182
 None
 1.38A 2zj0A-3pl1A:
2.8		 2zj0A-3pl1A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgk UREASE SUBUNIT BETA
2

(Helicobacter
mustelae) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 GLN C 209
THR C 172
THR C 491
LEU C 506
 None
 1.36A 2zj0A-3qgkC:
undetectable		 2zj0A-3qgkC:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr5 CARDIAC CA2+ RELEASE
CHANNEL

(Mus musculus) 		PF08709
(Ins145_P3_rec) 		4 GLN A  33
THR A  27
THR A 210
HIS A 193
 None
 1.13A 2zj0A-3qr5A:
undetectable		 2zj0A-3qr5A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122

(Staphylococcus
aureus) 		PF00171
(Aldedh) 		4 THR A 222
THR A 150
HIS A 103
LEU A  92
 None
 1.25A 2zj0A-3ty7A:
2.5		 2zj0A-3ty7A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Homo sapiens) 		PF00079
(Serpin) 		4 THR A  93
THR A 369
HIS A 364
LEU A 233
 None
 1.23A 2zj0A-3ut3A:
undetectable		 2zj0A-3ut3A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbe BETA-CYANOALNINE
SYNTHASE

(Glycine max) 		PF00291
(PALP) 		4 GLN A 331
THR A  74
THR A 342
HIS A 344
 None
 1.35A 2zj0A-3vbeA:
5.3		 2zj0A-3vbeA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x27 CUCUMOPINE SYNTHASE

(Marinactinospora
thermotolerans) 		no annotation 4 GLN A 168
THR A 171
THR A 263
LEU A 219
 None
 1.40A 2zj0A-3x27A:
undetectable		 2zj0A-3x27A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 THR A 594
THR A 653
HIS A 603
LEU A 616
 None
 1.18A 2zj0A-4c3hA:
undetectable		 2zj0A-4c3hA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnk L-AMINO ACID OXIDASE

(Streptococcus
cristatus) 		PF03486
(HI0933_like) 		4 GLN A 156
THR A   6
THR A 348
HIS A 389
 None
 1.15A 2zj0A-4cnkA:
2.2		 2zj0A-4cnkA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efc ADENYLOSUCCINATE
LYASE

(Trypanosoma
brucei) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		4 GLN A  33
THR A  34
HIS A 280
LEU A 329
 None
 1.22A 2zj0A-4efcA:
undetectable		 2zj0A-4efcA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkl BETA-GLUCURONIDASE

(Streptococcus
agalactiae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 GLN A 358
THR A 373
HIS A 383
LEU A 136
 None
 1.38A 2zj0A-4jklA:
undetectable		 2zj0A-4jklA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK

(Escherichia
coli) 		PF02733
(Dak1) 		4 THR A 129
THR A 153
HIS A  60
LEU A  69
 None
 1.33A 2zj0A-4lryA:
2.9		 2zj0A-4lryA:
23.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 GLN A  62
THR A  63
THR A 198
HIS A 342
LEU A 383
 NH4  A 502 ( 3.1A)
ADN  A 501 (-4.5A)
NAD  A 503 ( 2.9A)
ADN  A 501 ( 3.7A)
NAD  A 503 ( 3.9A)
 0.60A 2zj0A-4lvcA:
59.2		 2zj0A-4lvcA:
58.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmp SIALIC ACID BINDING
PROTEIN

(Pasteurella
multocida) 		PF03480
(DctP) 		4 GLN A 130
THR A 131
THR A 155
LEU A 281
 None
 1.40A 2zj0A-4mmpA:
undetectable		 2zj0A-4mmpA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Desulfovibrio
salexigens) 		PF03480
(DctP) 		4 THR A 229
THR A 235
HIS A 237
LEU A 185
 None
 0.96A 2zj0A-4n6kA:
undetectable		 2zj0A-4n6kA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn3 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 THR A 303
THR A 207
HIS A 202
LEU A   9
 None
 1.32A 2zj0A-4qn3A:
undetectable		 2zj0A-4qn3A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Rhizobium etli) 		PF01547
(SBP_bac_1) 		4 GLN A 274
THR A 273
HIS A 197
LEU A 195
 None
 1.18A 2zj0A-4rk2A:
undetectable		 2zj0A-4rk2A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvm CITRATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00285
(Citrate_synt) 		4 GLN A 111
THR A 195
THR A 204
LEU A 389
 None
 1.35A 2zj0A-4tvmA:
undetectable		 2zj0A-4tvmA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubq BETA-LACTAMASE

(Acinetobacter
baumannii) 		no annotation 4 GLN A 213
THR A 210
THR A 141
HIS A  78
 None
None
None
ZN  A 301 (-3.4A)
 1.28A 2zj0A-4ubqA:
2.8		 2zj0A-4ubqA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upk PHOSPHONATE
MONOESTER HYDROLASE

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		4 THR A 341
THR A 209
HIS A 207
LEU A  61
 None
 1.32A 2zj0A-4upkA:
undetectable		 2zj0A-4upkA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLN A 138
THR A 283
HIS A 147
LEU A 146
 None
 1.25A 2zj0A-4usfA:
undetectable		 2zj0A-4usfA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 THR A 224
THR A 283
HIS A 147
LEU A 146
 None
 1.13A 2zj0A-4usfA:
undetectable		 2zj0A-4usfA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wct FRUCTOSYL
AMINE:OXYGEN
OXIDOREDUCTASE

(Aspergillus
fumigatus) 		PF01266
(DAO) 		4 GLN A  93
THR A  88
HIS A  27
LEU A  26
 None
 1.20A 2zj0A-4wctA:
undetectable		 2zj0A-4wctA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wss HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 GLN A  15
THR A  14
HIS A 439
LEU A 436
 None
 1.22A 2zj0A-4wssA:
undetectable		 2zj0A-4wssA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgi GLUTAMATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 GLN A 259
THR A 283
HIS A 279
LEU A 276
 NAD  A 500 ( 4.9A)
None
None
None
 1.29A 2zj0A-4xgiA:
3.1		 2zj0A-4xgiA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLN A 523
THR A 539
HIS A 586
LEU A 577
 None
4CV  A 801 (-2.8A)
None
None
 1.20A 2zj0A-4yffA:
undetectable		 2zj0A-4yffA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA

(Methanothermobacter
marburgensis) 		PF02240
(MCR_gamma) 		4 THR C 119
THR C 218
HIS C  21
LEU C 145
 None
 1.30A 2zj0A-5a8rC:
undetectable		 2zj0A-5a8rC:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3r IMP-18

(Pseudomonas
aeruginosa) 		no annotation 4 GLN A 230
THR A 227
THR A 158
HIS A  95
 None
None
None
ZN  A2001 ( 3.4A)
 1.28A 2zj0A-5b3rA:
3.0		 2zj0A-5b3rA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv5 CYTOCHROME P450 119

(Sulfolobus
solfataricus) 		PF00067
(p450) 		4 GLN A  90
THR A  94
HIS A 178
LEU A 179
 None
 1.37A 2zj0A-5bv5A:
undetectable		 2zj0A-5bv5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1

(Chaetomium
thermophilum) 		PF00400
(WD40) 		4 GLN B 637
THR B 652
HIS B 701
LEU B 699
 None
 1.22A 2zj0A-5cxcB:
undetectable		 2zj0A-5cxcB:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8g TRYPTOPHANASE

(Escherichia
coli) 		PF01212
(Beta_elim_lyase) 		4 GLN A 140
THR A 138
HIS A 463
LEU A 400
 None
None
None
EPE  A1003 (-4.3A)
 1.15A 2zj0A-5d8gA:
2.8		 2zj0A-5d8gA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du3 PLASMA PROTEASE C1
INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		4 GLN A 201
THR A 157
HIS A 185
LEU A 221
 None
 1.29A 2zj0A-5du3A:
undetectable		 2zj0A-5du3A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLN A 530
THR A 529
HIS A 574
LEU A 567
 None
5XJ  A 801 (-3.4A)
None
None
 1.31A 2zj0A-5fd2A:
undetectable		 2zj0A-5fd2A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffn ENZYME SUBTILASE
SUBTY FROM BACILLUS
SP. TY145

(Bacillus sp.
(in: Bacteria)) 		PF00082
(Peptidase_S8) 		4 GLN A   6
THR A   5
THR A  79
HIS A 256
 None
 1.39A 2zj0A-5ffnA:
4.1		 2zj0A-5ffnA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 GLN D 313
THR D 315
HIS D 149
LEU D 265
 None
 1.38A 2zj0A-5fl7D:
undetectable		 2zj0A-5fl7D:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 GLN C 211
THR C 174
THR C 493
LEU C 508
 None
 1.34A 2zj0A-5fseC:
3.4		 2zj0A-5fseC:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g23 TYPE-IV LIKE PILIN
TTHA1219

(Thermus
thermophilus) 		no annotation 4 GLN A  84
THR A 107
THR A 231
LEU A 178
 None
 1.38A 2zj0A-5g23A:
undetectable		 2zj0A-5g23A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lde IMMUNOGLOBULIN
G-BINDING PROTEIN
G,VIRAL FLICE
PROTEIN

(Human
gammaherpesvirus
8;
Streptococcus
sp. 'group G') 		PF01335
(DED)
PF01378
(IgG_binding_B) 		4 THR A 152
THR A 187
HIS A 183
LEU A 180
 None
 1.34A 2zj0A-5ldeA:
undetectable		 2zj0A-5ldeA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE

(Shewanella
oneidensis) 		PF03060
(NMO) 		4 GLN A 326
THR A 156
HIS A 185
LEU A 191
 None
 1.23A 2zj0A-5lsmA:
undetectable		 2zj0A-5lsmA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n94 CG9323, ISOFORM A

(Drosophila
melanogaster) 		no annotation 4 THR A 513
THR A 489
HIS A 463
LEU A 465
 U  C   3 ( 2.9A)
U  C   4 ( 2.9A)
U  C   4 ( 3.8A)
U  C   2 ( 4.3A)
 1.39A 2zj0A-5n94A:
3.6		 2zj0A-5n94A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nci LEUCINE HYDROXYLASE

(Streptomyces
muensis) 		PF05721
(PhyH) 		4 GLN A 111
THR A 227
HIS A  92
LEU A 122
 None
 1.25A 2zj0A-5nciA:
undetectable		 2zj0A-5nciA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 4 GLN A 467
THR A 468
THR A 520
LEU A 608
 None
 0.97A 2zj0A-5nd1A:
undetectable		 2zj0A-5nd1A:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swk DE NOVO PROTEIN
BASED ON THE
INHIBITOR
AMOEBIASIN-1
E3 UBIQUITIN-PROTEIN
LIGASE MDM2

(Entamoeba
histolytica;
Homo sapiens) 		no annotation 4 GLN A  72
THR C  85
HIS A  96
LEU C  94
 None
 1.10A 2zj0A-5swkA:
undetectable		 2zj0A-5swkA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		4 GLN A 188
THR A 184
THR A 134
LEU A 102
 None
NAP  A 301 (-3.0A)
NAP  A 301 (-4.2A)
None
 1.35A 2zj0A-5t2uA:
8.3		 2zj0A-5t2uA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u02 GLYCOSYL TRANSFERASE

(Staphylococcus
aureus) 		no annotation 4 GLN A 283
THR A 259
HIS A 253
LEU A 250
 None
 1.38A 2zj0A-5u02A:
undetectable		 2zj0A-5u02A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		4 GLN A  24
THR A  20
THR A 348
LEU A 331
 None
UDP  A 503 ( 4.3A)
None
None
 1.31A 2zj0A-5u6sA:
3.6		 2zj0A-5u6sA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36

(Bos taurus) 		no annotation 4 THR A 577
THR A 553
HIS A 527
LEU A 529
 None
 1.31A 2zj0A-5vhaA:
3.4		 2zj0A-5vhaA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 GLN B1065
THR B1090
HIS B1025
LEU B1026
 None
 1.30A 2zj0A-5xogB:
undetectable		 2zj0A-5xogB:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zq6 SIDE

(Legionella
pneumophila) 		no annotation 4 GLN A 272
THR A 282
HIS A 403
LEU A 407
 None
None
ADP  A1101 (-4.0A)
ADP  A1101 (-4.8A)
 1.23A 2zj0A-5zq6A:
undetectable		 2zj0A-5zq6A:
8.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6aph ADENOSYLHOMOCYSTEINA
SE

(Elizabethkingia
anophelis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 GLN A  62
THR A  63
THR A 162
HIS A 306
LEU A 349
 ADN  A 501 (-3.8A)
ADN  A 501 (-4.5A)
NAD  A 500 ( 2.9A)
ADN  A 501 ( 3.7A)
NAD  A 500 ( 4.3A)
 0.33A 2zj0A-6aphA:
29.7		 2zj0A-6aphA:
54.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3

(Homo sapiens) 		no annotation 4 GLN A 466
THR A 378
THR A 203
HIS A 373
 None
None
None
ZN  A 902 (-3.3A)
 1.03A 2zj0A-6c01A:
undetectable		 2zj0A-6c01A:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-) 		no annotation 4 GLN A 466
THR A 379
THR A 204
HIS A 374
 None
None
None
ZN  A1002 (-3.1A)
 1.05A 2zj0A-6f2tA:
undetectable		 2zj0A-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 5 GLN B  65
THR B  66
THR B 165
HIS B 323
LEU B 373
 K  B 504 ( 3.0A)
ADN  B 502 (-4.6A)
NAD  B 501 ( 2.8A)
ZN  B 505 (-3.2A)
NAD  B 501 ( 3.9A)
 0.54A 2zj0A-6f3mB:
51.8		 2zj0A-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila) 		no annotation 4 GLN A 275
THR A 285
HIS A 407
LEU A 411
 None
 1.37A 2zj0A-6g0cA:
undetectable		 2zj0A-6g0cA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-) 		no annotation 5 GLN A  60
THR A  61
THR A 160
HIS A 304
LEU A 347
 NA  A 503 ( 3.2A)
ADN  A 501 (-4.6A)
NAD  A 502 ( 2.8A)
ADN  A 501 ( 3.6A)
NAD  A 502 (-3.9A)
 0.64A 2zj0A-6gbnA:
30.5		 2zj0A-6gbnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7mdh PROTEIN (MALATE
DEHYDROGENASE)

(Sorghum bicolor) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLN A 208
THR A 198
HIS A 229
LEU A 385
 None
None
ZN  A 501 (-2.9A)
ZN  A 503 (-4.0A)
 1.40A 2zj0A-7mdhA:
undetectable		 2zj0A-7mdhA:
22.24