SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZIF_B_SAMB298_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a7j PHOSPHORIBULOKINASE

(Rhodobacter
sphaeroides) 		PF00485
(PRK) 		3 ASP A 169
THR A  11
GLU A 161
 None
 0.76A 2zifB-1a7jA:
undetectable		 2zifB-1a7jA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris) 		PF01555
(N6_N4_Mtase) 		3 ASP A  34
THR A 278
GLU A 294
 SAH  A 401 (-4.0A)
SAH  A 401 (-4.0A)
SAH  A 401 (-2.9A)
 0.25A 2zifB-1booA:
22.2		 2zifB-1booA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3n AGGLUTININ

(Helianthus
tuberosus) 		PF01419
(Jacalin) 		3 ASP A  66
THR A  99
GLU A  69
 None
 0.72A 2zifB-1c3nA:
undetectable		 2zifB-1c3nA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ct9 ASPARAGINE
SYNTHETASE B

(Escherichia
coli) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		3 ASP A 462
THR A 490
GLU A 493
 None
 0.75A 2zifB-1ct9A:
1.4		 2zifB-1ct9A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dr9 T LYMPHOCYTE
ACTIVATION ANTIGEN

(Homo sapiens) 		PF07686
(V-set)
PF08205
(C2-set_2) 		3 ASP A 107
THR A  13
GLU A  10
 None
 0.83A 2zifB-1dr9A:
undetectable		 2zifB-1dr9A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5t DIPHTHERIA TOXIN
REPRESSOR

(Corynebacterium
diphtheriae) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C) 		3 ASP A1099
THR A1008
GLU A1105
 None
None
NI  A 251 (-2.6A)
 0.82A 2zifB-1f5tA:
undetectable		 2zifB-1f5tA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbv SIGNAL TRANSDUCTION
PROTEIN CBL

(Homo sapiens) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3)
PF14447
(Prok-RING_4) 		3 ASP A 390
THR A  50
GLU A 120
 None
 0.77A 2zifB-1fbvA:
undetectable		 2zifB-1fbvA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gmz PHOSPHOLIPASE A2

(Bothrops
pirajai) 		PF00068
(Phospholip_A2_1) 		3 ASP A 101
THR A  72
GLU A  98
 None
 0.70A 2zifB-1gmzA:
undetectable		 2zifB-1gmzA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h74 HOMOSERINE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 ASP A  42
THR A  57
GLU A  45
 None
 0.82A 2zifB-1h74A:
undetectable		 2zifB-1h74A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyn BAND 3 ANION
TRANSPORT PROTEIN

(Homo sapiens) 		PF07565
(Band_3_cyto) 		3 ASP P 277
THR P 179
GLU P 272
 None
 0.70A 2zifB-1hynP:
undetectable		 2zifB-1hynP:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibv HISTIDINE
DECARBOXYLASE ALPHA
CHAIN

(Lactobacillus
sp. 30A) 		PF02329
(HDC) 		3 ASP B 279
THR B 289
GLU B 286
 None
 0.66A 2zifB-1ibvB:
undetectable		 2zifB-1ibvB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		3 ASP A 582
THR A 506
GLU A 500
 CL  A2004 (-4.9A)
None
None
 0.83A 2zifB-1itkA:
undetectable		 2zifB-1itkA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7h ALKALINE PHOSPHATASE

(Pandalus
borealis) 		PF00245
(Alk_phosphatase) 		3 ASP A 251
THR A 271
GLU A 216
 None
SO4  A 483 ( 4.5A)
None
 0.76A 2zifB-1k7hA:
undetectable		 2zifB-1k7hA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8m E2 COMPONENT OF
BRANCHED-CHAIN
ALPHA-KETOACID
DEHYDROGENASE

(Homo sapiens) 		PF00364
(Biotin_lipoyl) 		3 ASP A  36
THR A  20
GLU A  40
 None
 0.63A 2zifB-1k8mA:
undetectable		 2zifB-1k8mA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lln ANTIVIRAL PROTEIN 3

(Phytolacca
americana) 		PF00161
(RIP) 		3 ASP A 249
THR A  10
GLU A 180
 None
None
MLY  A 177 ( 3.3A)
 0.68A 2zifB-1llnA:
undetectable		 2zifB-1llnA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llp LIGNIN PEROXIDASE

(Phanerochaete
chrysosporium) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		3 ASP A 238
THR A 333
GLU A 207
 None
 0.83A 2zifB-1llpA:
undetectable		 2zifB-1llpA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		3 ASP A 178
THR A 325
GLU A 174
 None
 0.74A 2zifB-1lnsA:
1.9		 2zifB-1lnsA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		3 ASP A 259
THR A 266
GLU A 167
 None
 0.76A 2zifB-1lnsA:
1.9		 2zifB-1lnsA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN

(Archaeoglobus
fulgidus) 		PF01269
(Fibrillarin) 		3 ASP A 113
THR A  71
GLU A  88
 SAM  A 301 (-3.6A)
SAM  A 301 (-4.1A)
SAM  A 301 (-2.4A)
 0.77A 2zifB-1nt2A:
4.1		 2zifB-1nt2A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		3 ASP A 602
THR A 556
GLU A 563
 None
 0.80A 2zifB-1ofeA:
undetectable		 2zifB-1ofeA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		3 ASP A 294
THR A 196
GLU A 202
 None
 0.79A 2zifB-1q8yA:
undetectable		 2zifB-1q8yA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu7 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN I

(Escherichia
coli) 		PF00015
(MCPsignal) 		3 ASP A 464
THR A 450
GLU A 458
 None
 0.71A 2zifB-1qu7A:
undetectable		 2zifB-1qu7A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc9 CYSTEINE-RICH
SECRETORY PROTEIN

(Trimeresurus
stejnegeri) 		PF00188
(CAP)
PF08562
(Crisp) 		3 ASP A  47
THR A 184
GLU A  69
 None
 0.68A 2zifB-1rc9A:
undetectable		 2zifB-1rc9A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t34 ATRIAL NATRIURETIC
PEPTIDE RECEPTOR A

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		3 ASP A  39
THR A 349
GLU A 334
 None
 0.84A 2zifB-1t34A:
undetectable		 2zifB-1t34A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ASP A 461
THR A 380
GLU A 386
 None
 0.75A 2zifB-1u59A:
undetectable		 2zifB-1u59A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uw4 UPF3X
REGULATOR OF
NONSENSE TRANSCRIPTS
2

(Homo sapiens;
Homo sapiens) 		PF03467
(Smg4_UPF3)
PF02854
(MIF4G) 		3 ASP B 840
THR A  63
GLU A  81
 None
 0.73A 2zifB-1uw4B:
undetectable		 2zifB-1uw4B:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux1 CYTIDINE DEAMINASE

(Bacillus
subtilis) 		PF00383
(dCMP_cyt_deam_1) 		3 ASP A 100
THR A 106
GLU A 114
 None
 0.75A 2zifB-1ux1A:
undetectable		 2zifB-1ux1A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME

(Campylobacter
jejuni) 		PF01128
(IspD)
PF02542
(YgbB) 		3 ASP A  31
THR A 212
GLU A 209
 None
 0.72A 2zifB-1w55A:
undetectable		 2zifB-1w55A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wj3 KIAA1496 PROTEIN

(Homo sapiens) 		PF00041
(fn3) 		3 ASP A  31
THR A  73
GLU A  76
 None
 0.73A 2zifB-1wj3A:
undetectable		 2zifB-1wj3A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wls L-ASPARAGINASE

(Pyrococcus
horikoshii) 		PF00710
(Asparaginase) 		3 ASP A  84
THR A 261
GLU A 293
 None
 0.63A 2zifB-1wlsA:
undetectable		 2zifB-1wlsA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9n DNA LIGASE I

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		3 ASP A 730
THR A 506
GLU A 734
 None
 0.73A 2zifB-1x9nA:
undetectable		 2zifB-1x9nA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7u HYPOTHETICAL PROTEIN
EF0647

(Enterococcus
faecalis) 		PF01638
(HxlR) 		3 ASP A  43
THR A  32
GLU A  27
 None
 0.76A 2zifB-1z7uA:
undetectable		 2zifB-1z7uA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbx ORIGIN RECOGNITION
COMPLEX SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF01426
(BAH) 		3 ASP A 154
THR A 126
GLU A 131
 None
 0.59A 2zifB-1zbxA:
undetectable		 2zifB-1zbxA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvu TOPOISOMERASE IV
SUBUNIT A

(Escherichia
coli) 		PF00521
(DNA_topoisoIV)
PF03989
(DNA_gyraseA_C) 		3 ASP A 591
THR A 501
GLU A 588
 None
 0.83A 2zifB-1zvuA:
undetectable		 2zifB-1zvuA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkl PROLYL ENDOPEPTIDASE

(Myxococcus
xanthus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 ASP A 118
THR A  87
GLU A  92
 None
 0.81A 2zifB-2bklA:
undetectable		 2zifB-2bklA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bw3 TRANSPOSASE
TRANSPOSASE

(Musca
domestica;
Musca domestica) 		PF05699
(Dimer_Tnp_hAT)
PF10683
(DBD_Tnp_Hermes)
PF10683
(DBD_Tnp_Hermes) 		3 ASP B 133
THR B  85
GLU A 130
 None
 0.83A 2zifB-2bw3B:
undetectable		 2zifB-2bw3B:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Prosthecochloris
vibrioformis) 		PF00490
(ALAD) 		3 ASP A  75
THR A  62
GLU A  69
 None
 0.78A 2zifB-2c1hA:
undetectable		 2zifB-2c1hA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like) 		3 ASP A  42
THR A 292
GLU A  37
 MG  A 401 (-2.5A)
None
None
 0.77A 2zifB-2cw6A:
undetectable		 2zifB-2cw6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		3 ASP A 167
THR A  59
GLU A  56
 None
 0.74A 2zifB-2d62A:
2.4		 2zifB-2d62A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec9 TISSUE FACTOR

(Homo sapiens) 		PF01108
(Tissue_fac) 		3 ASP T  54
THR T  17
GLU T  24
 None
 0.78A 2zifB-2ec9T:
undetectable		 2zifB-2ec9T:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase) 		3 ASP A  68
THR A 106
GLU A 114
 None
 0.83A 2zifB-2f2aA:
undetectable		 2zifB-2f2aA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fdb FIBROBLAST GROWTH
FACTOR 8 ISOFORM B

(Homo sapiens) 		PF00167
(FGF) 		3 ASP M  44
THR M  53
GLU M  89
 None
 0.77A 2zifB-2fdbM:
undetectable		 2zifB-2fdbM:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		3 ASP A 189
THR A 250
GLU A 217
 None
 0.80A 2zifB-2fpgA:
undetectable		 2zifB-2fpgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE

(Pseudomonas
aeruginosa) 		PF00682
(HMGL-like) 		3 ASP A  16
THR A 266
GLU A  11
 NA  A3000 (-2.9A)
None
None
 0.76A 2zifB-2ftpA:
undetectable		 2zifB-2ftpA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hal HEPATITIS A PROTEASE
3C

(Hepatovirus A) 		PF00548
(Peptidase_C3) 		3 ASP A  51
THR A 152
GLU A  49
 None
 0.82A 2zifB-2halA:
undetectable		 2zifB-2halA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hoe N-ACETYLGLUCOSAMINE
KINASE

(Thermotoga
maritima) 		PF00480
(ROK) 		3 ASP A  85
THR A 141
GLU A  81
 None
 0.81A 2zifB-2hoeA:
undetectable		 2zifB-2hoeA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0o SER/THR PHOSPHATASE

(Anopheles
gambiae) 		PF00481
(PP2C) 		3 ASP A 500
THR A 525
GLU A 438
 None
 0.80A 2zifB-2i0oA:
undetectable		 2zifB-2i0oA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idv EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4E-1

(Triticum
aestivum) 		PF01652
(IF4E) 		3 ASP A 148
THR A  74
GLU A  43
 None
 0.69A 2zifB-2idvA:
undetectable		 2zifB-2idvA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ie8 PHOSPHOGLYCERATE
KINASE

(Thermus
caldophilus) 		PF00162
(PGK) 		3 ASP A 197
THR A 381
GLU A 378
 None
 0.80A 2zifB-2ie8A:
3.0		 2zifB-2ie8A:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN

(Homo sapiens) 		PF01269
(Fibrillarin) 		3 ASP A 217
THR A 174
GLU A 192
 MTA  A4001 (-3.4A)
None
MTA  A4001 (-2.7A)
 0.68A 2zifB-2ipxA:
3.4		 2zifB-2ipxA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 YDR362CP

(Saccharomyces
cerevisiae) 		no annotation 3 ASP B 460
THR B 451
GLU B 447
 None
 0.77A 2zifB-2j04B:
undetectable		 2zifB-2j04B:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5c 1,8-CINEOLE SYNTHASE

(Salvia
fruticosa) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 ASP A 400
THR A 335
GLU A 330
 None
 0.69A 2zifB-2j5cA:
undetectable		 2zifB-2j5cA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5g ALR4455 PROTEIN

(Nostoc sp. PCC
7120) 		PF00378
(ECH_1) 		3 ASP D  69
THR D  39
GLU D  74
 None
 0.74A 2zifB-2j5gD:
undetectable		 2zifB-2j5gD:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jqv AIG2 PROTEIN-LIKE

(Arabidopsis
thaliana) 		PF06094
(GGACT) 		3 ASP A 113
THR A  90
GLU A  87
 None
 0.64A 2zifB-2jqvA:
undetectable		 2zifB-2jqvA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kd7 PUTATIVE CHITOBIASE

(Bacteroides
thetaiotaomicron) 		PF00754
(F5_F8_type_C) 		3 ASP A 130
THR A  98
GLU A  87
 None
 0.79A 2zifB-2kd7A:
undetectable		 2zifB-2kd7A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l8b PROTEIN TRAI

(Escherichia
coli) 		no annotation 3 ASP A 479
THR A 504
GLU A 485
 None
 0.72A 2zifB-2l8bA:
1.7		 2zifB-2l8bA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okl PEPTIDE DEFORMYLASE
2

(Bacillus cereus) 		PF01327
(Pep_deformylase) 		3 ASP A  30
THR A   3
GLU A  36
 None
 0.65A 2zifB-2oklA:
undetectable		 2zifB-2oklA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF16073
(SAT) 		3 ASP B  51
THR B 128
GLU B 121
 None
 0.81A 2zifB-2pffB:
undetectable		 2zifB-2pffB:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptt CD48 ANTIGEN

(Mus musculus) 		PF07686
(V-set) 		3 ASP A 104
THR A  83
GLU A 101
 None
 0.72A 2zifB-2pttA:
undetectable		 2zifB-2pttA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2puq TISSUE FACTOR

(Homo sapiens) 		PF01108
(Tissue_fac)
PF09294
(Interfer-bind) 		3 ASP T  54
THR T  17
GLU T  24
 None
 0.81A 2zifB-2puqT:
undetectable		 2zifB-2puqT:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnf RECOMBINATION
ENDONUCLEASE VII

(Escherichia
virus T4) 		PF02945
(Endonuclease_7)
PF09124
(Endonuc-dimeris) 		3 ASP A  17
THR A   4
GLU A  11
 None
 0.82A 2zifB-2qnfA:
undetectable		 2zifB-2qnfA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy6 UPF0209 PROTEIN YFCK

(Escherichia
coli) 		PF05430
(Methyltransf_30) 		3 ASP A 198
THR A 126
GLU A 121
 None
 0.68A 2zifB-2qy6A:
2.0		 2zifB-2qy6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vjt ALLOPHYCOCYANIN
ALPHA SUBUNIT

(Gloeobacter
violaceus) 		PF00502
(Phycobilisome) 		3 ASP A 100
THR A 138
GLU A 148
 None
 0.75A 2zifB-2vjtA:
undetectable		 2zifB-2vjtA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vro ALDEHYDE
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00171
(Aldedh) 		3 ASP A 389
THR A 415
GLU A 306
 None
 0.76A 2zifB-2vroA:
undetectable		 2zifB-2vroA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vtx NPM-A PROTEIN

(Xenopus laevis) 		PF03066
(Nucleoplasmin) 		3 ASP A  67
THR A  80
GLU A  64
 None
 0.75A 2zifB-2vtxA:
undetectable		 2zifB-2vtxA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum) 		PF00245
(Alk_phosphatase) 		3 ASP A 304
THR A 187
GLU A 167
 ZN  A1475 ( 2.0A)
None
None
 0.74A 2zifB-2x98A:
undetectable		 2zifB-2x98A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd7 CORE HISTONE
MACRO-H2A.2

(Homo sapiens) 		PF01661
(Macro) 		3 ASP A 339
THR A 325
GLU A 291
 None
 0.76A 2zifB-2xd7A:
undetectable		 2zifB-2xd7A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfx MHC CLASS 1

(Bos taurus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 ASP A 129
THR A 163
GLU A 161
 None
 0.79A 2zifB-2xfxA:
undetectable		 2zifB-2xfxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 ASP A 274
THR A 326
GLU A 329
 None
 0.68A 2zifB-2yd0A:
undetectable		 2zifB-2yd0A:
15.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zie PUTATIVE
MODIFICATION
METHYLASE

(Thermus
thermophilus) 		PF01555
(N6_N4_Mtase) 		3 ASP A  28
THR A 248
GLU A 264
 None
 0.47A 2zifB-2zieA:
38.4		 2zifB-2zieA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5r BENZALACETONE
SYNTHASE

(Rheum palmatum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 ASP A 220
THR A 353
GLU A 231
 None
 0.74A 2zifB-3a5rA:
undetectable		 2zifB-3a5rA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajz ANCESTRAL CONGERIN
CON-ANC

(-) 		PF00337
(Gal-bind_lectin) 		3 ASP A  37
THR A   8
GLU A  34
 None
 0.65A 2zifB-3ajzA:
undetectable		 2zifB-3ajzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbj PUTATIVE
THIOESTERASE II

(Thermobifida
fusca) 		PF13622
(4HBT_3) 		3 ASP A 251
THR A 169
GLU A 172
 None
 0.81A 2zifB-3bbjA:
undetectable		 2zifB-3bbjA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR

(Bacillus
subtilis) 		PF04198
(Sugar-bind) 		3 ASP A 278
THR A 100
GLU A 315
 None
 0.76A 2zifB-3bxhA:
undetectable		 2zifB-3bxhA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		3 ASP A 141
THR A  56
GLU A  62
 None
 0.73A 2zifB-3c0iA:
undetectable		 2zifB-3c0iA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3m RESPONSE REGULATOR
RECEIVER PROTEIN

(Methanoculleus
marisnigri) 		PF00072
(Response_reg) 		3 ASP A  10
THR A  45
GLU A  37
 None
GOL  A 202 (-3.7A)
None
 0.79A 2zifB-3c3mA:
undetectable		 2zifB-3c3mA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfz UPF0100 PROTEIN
MJ1186

(Methanocaldococcus
jannaschii) 		PF13531
(SBP_bac_11) 		3 ASP A 126
THR A 222
GLU A 229
 None
 0.80A 2zifB-3cfzA:
undetectable		 2zifB-3cfzA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cm5 CELL DEATH-RELATED
NUCLEASE 4

(Caenorhabditis
elegans) 		PF00929
(RNase_T) 		3 ASP A 111
THR A 209
GLU A 206
 None
 0.84A 2zifB-3cm5A:
undetectable		 2zifB-3cm5A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		3 ASP A 238
THR A 156
GLU A 160
 None
 0.75A 2zifB-3ctzA:
undetectable		 2zifB-3ctzA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0c DIHYDRODIPICOLINATE
SYNTHASE

(Oceanobacillus
iheyensis) 		PF00701
(DHDPS) 		3 ASP A 242
THR A  12
GLU A 195
 None
 0.76A 2zifB-3d0cA:
undetectable		 2zifB-3d0cA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3a BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01301
(Glyco_hydro_35) 		3 ASP A 326
THR A 543
GLU A 331
 None
 0.83A 2zifB-3d3aA:
undetectable		 2zifB-3d3aA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3y UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF05193
(Peptidase_M16_C) 		3 ASP A 199
THR A 384
GLU A 372
 None
 0.83A 2zifB-3d3yA:
undetectable		 2zifB-3d3yA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsm UNCHARACTERIZED
PROTEIN BACUNI_02894

(Bacteroides
uniformis) 		no annotation 3 ASP A 204
THR A  21
GLU A 243
 None
 0.79A 2zifB-3dsmA:
undetectable		 2zifB-3dsmA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxp PUTATIVE ACYL-COA
DEHYDROGENASE

(Cupriavidus
pinatubonensis) 		PF01636
(APH) 		3 ASP A  96
THR A 141
GLU A 146
 None
ACT  A 360 (-4.3A)
None
 0.77A 2zifB-3dxpA:
undetectable		 2zifB-3dxpA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e96 DIHYDRODIPICOLINATE
SYNTHASE

(Bacillus
clausii) 		PF00701
(DHDPS) 		3 ASP A 244
THR A  14
GLU A 197
 None
 0.73A 2zifB-3e96A:
undetectable		 2zifB-3e96A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehm SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		3 ASP A 156
THR A 219
GLU A 159
 None
 0.83A 2zifB-3ehmA:
undetectable		 2zifB-3ehmA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqz RESPONSE REGULATOR

(Colwellia
psychrerythraea) 		PF00072
(Response_reg) 		3 ASP A  57
THR A  40
GLU A  62
 ASP  A  57 ( 0.5A)
THR  A  40 ( 0.8A)
GLU  A  62 ( 0.6A)
 0.81A 2zifB-3eqzA:
2.5		 2zifB-3eqzA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g25 GLYCEROL KINASE

(Staphylococcus
aureus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ASP A 125
THR A 207
GLU A 201
 None
 0.83A 2zifB-3g25A:
undetectable		 2zifB-3g25A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gjy SPERMIDINE SYNTHASE

(Corynebacterium
glutamicum) 		no annotation 3 ASP A 144
THR A  99
GLU A 117
 None
None
FMT  A 315 (-3.6A)
 0.58A 2zifB-3gjyA:
2.5		 2zifB-3gjyA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ASP A 323
THR A  42
GLU A 407
 None
 0.73A 2zifB-3gyrA:
undetectable		 2zifB-3gyrA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgq HDA1 COMPLEX SUBUNIT
3

(Saccharomyces
cerevisiae) 		PF11496
(HDA2-3) 		3 ASP A 256
THR A 318
GLU A 261
 None
 0.72A 2zifB-3hgqA:
undetectable		 2zifB-3hgqA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hst PROTEIN
RV2228C/MT2287

(Mycobacterium
tuberculosis) 		PF13456
(RVT_3) 		3 ASP B 128
THR B  31
GLU B  35
 None
 0.75A 2zifB-3hstB:
undetectable		 2zifB-3hstB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11

(Schizosaccharomyces
pombe) 		PF13087
(AAA_12)
PF16399
(Aquarius_N) 		3 ASP X1076
THR X1236
GLU X1085
 None
 0.64A 2zifB-3jb9X:
undetectable		 2zifB-3jb9X:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ka7 OXIDOREDUCTASE

(Methanosarcina
mazei) 		PF01593
(Amino_oxidase) 		3 ASP A 240
THR A 215
GLU A  27
 None
 0.81A 2zifB-3ka7A:
undetectable		 2zifB-3ka7A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kar KINESIN-LIKE PROTEIN
KAR3

(Saccharomyces
cerevisiae) 		PF00225
(Kinesin) 		3 ASP A 414
THR A 425
GLU A 435
 None
 0.64A 2zifB-3karA:
undetectable		 2zifB-3karA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjl PROTEIN SUS1
SAGA-ASSOCIATED
FACTOR 11

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF10163
(EnY2)
no annotation 		3 ASP A  40
THR A  56
GLU E  31
 None
 0.66A 2zifB-3kjlA:
undetectable		 2zifB-3kjlA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ASP A 118
THR A 335
GLU A 463
 None
NAG  A 706 (-4.5A)
None
 0.84A 2zifB-3kw7A:
undetectable		 2zifB-3kw7A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l57 MOBILIZATION PROTEIN
TRAI

(Escherichia
coli) 		PF08751
(TrwC) 		3 ASP A 102
THR A  34
GLU A 150
 None
EDO  A 303 (-4.7A)
None
 0.79A 2zifB-3l57A:
undetectable		 2zifB-3l57A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmm UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF04326
(AlbA_2)
PF13749
(HATPase_c_4) 		3 ASP A 328
THR A 283
GLU A 295
 None
 0.65A 2zifB-3lmmA:
undetectable		 2zifB-3lmmA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgz 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00926
(DHBP_synthase) 		3 ASP A  25
THR A  53
GLU A  31
 None
 0.82A 2zifB-3mgzA:
undetectable		 2zifB-3mgzA:
20.47