SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZIF_B_SAMB298_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1avw | TRYPSIN INHIBITOR (Glycine max) |
PF00197(Kunitz_legume) | 6 | ALA B 531SER B 579PHE B 580GLY B 555THR B 516TYR B 518 | None | 1.31A | 2zifB-1avwB:undetectable | 2zifB-1avwB:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bhy | P64K (Neisseriameningitidis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ALA A 393GLY A 317THR A 318LEU A 305VAL A 329 | None | 1.16A | 2zifB-1bhyA:undetectable | 2zifB-1bhyA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1boo | PROTEIN (N-4CYTOSINE-SPECIFICMETHYLTRANSFERASEPVU II) (Proteusvulgaris) |
PF01555(N6_N4_Mtase) | 6 | SER A 53PRO A 55PHE A 250PHE A 273GLY A 275TYR A 299 | SAH A 401 (-3.4A)SAH A 401 (-3.9A)SAH A 401 (-3.4A)SAH A 401 (-4.6A)SAH A 401 (-3.5A)SAH A 401 (-4.2A) | 0.65A | 2zifB-1booA:22.2 | 2zifB-1booA:27.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c3l | SUBTILISIN-CARLSBERG (Bacilluslicheniformis) |
PF00082(Peptidase_S8) | 5 | SER A 98GLY A 65THR A 66LEU A 31VAL A 30 | None | 1.17A | 2zifB-1c3lA:undetectable | 2zifB-1c3lA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d4m | PROTEIN(COXSACKIEVIRUS A9) (Enterovirus B) |
PF00073(Rhv) | 5 | ALA 1 177PRO 1 178GLY 1 175LEU 1 140VAL 1 139 | None | 1.21A | 2zifB-1d4m1:undetectable | 2zifB-1d4m1:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e5f | METHIONINEGAMMA-LYASE (Trichomonasvaginalis) |
PF01053(Cys_Met_Meta_PP) | 5 | ALA A 275ALA A 157PRO A 156THR A 160LEU A 374 | None | 1.00A | 2zifB-1e5fA:undetectable | 2zifB-1e5fA:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1epv | ALANINE RACEMASE (Geobacillusstearothermophilus) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 5 | ALA A 54SER A 204ALA A 228PRO A 229GLY A 226 | NoneDCS A1001 (-1.9A)NoneNoneNone | 1.20A | 2zifB-1epvA:undetectable | 2zifB-1epvA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hpg | GLUTAMIC ACIDSPECIFIC PROTEASE (Streptomycesgriseus) |
no annotation | 5 | ALA A 226SER A 139ALA A 44GLY A 196THR A 54 | None | 1.07A | 2zifB-1hpgA:undetectable | 2zifB-1hpgA:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hww | ALPHA-MANNOSIDASE II (Drosophilamelanogaster) |
PF01074(Glyco_hydro_38)PF07748(Glyco_hydro_38C)PF09261(Alpha-mann_mid) | 5 | PRO A 594PRO A 576PHE A 577GLY A 662LEU A 659 | None | 1.17A | 2zifB-1hwwA:undetectable | 2zifB-1hwwA:14.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jio | CYTOCHROME P450107A1 (Saccharopolysporaerythraea) |
PF00067(p450) | 5 | ALA A 286GLY A 253THR A 254LEU A 282VAL A 278 | None | 1.17A | 2zifB-1jioA:undetectable | 2zifB-1jioA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jtd | BETA-LACTAMASEINHIBITOR PROTEIN II (Streptomycesexfoliatus) |
PF13540(RCC1_2) | 5 | ALA B 110SER B 266PRO B 303GLY B 189THR B 192 | NoneNoneNone CA B 502 ( 4.9A)None | 1.13A | 2zifB-1jtdB:undetectable | 2zifB-1jtdB:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k9a | CARBOXYL-TERMINALSRC KINASE (Rattusnorvegicus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 5 | ALA A 316SER A 381PRO A 386ALA A 407PRO A 408 | None | 1.21A | 2zifB-1k9aA:undetectable | 2zifB-1k9aA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ltm | 36 KDA SOLUBLE LYTICTRANSGLYCOSYLASE (Escherichiacoli) |
PF13406(SLT_2) | 5 | ALA A 218SER A 193ALA A 60PHE A 63PHE A 192 | EDO A 402 ( 3.8A)NoneNoneNoneNone | 1.09A | 2zifB-1ltmA:undetectable | 2zifB-1ltmA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m72 | CASPASE-1 (Spodopterafrugiperda) |
PF00656(Peptidase_C14) | 5 | ALA A 126ALA A 208PHE A 210GLY A 168VAL A 46 | None | 1.14A | 2zifB-1m72A:undetectable | 2zifB-1m72A:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pdz | ENOLASE (Homarusgammarus) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | ALA A 431PRO A 432GLY A 367LEU A 342VAL A 317 | None | 1.02A | 2zifB-1pdzA:undetectable | 2zifB-1pdzA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q9h | CELLOBIOHYDROLASE ICATALYTIC DOMAIN (Rasamsoniaemersonii) |
PF00840(Glyco_hydro_7) | 5 | SER A 112ALA A 160GLY A 165THR A 166LEU A 105 | NonePCA A 1 ( 3.7A)NoneNoneNone | 1.21A | 2zifB-1q9hA:undetectable | 2zifB-1q9hA:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xc6 | BETA-GALACTOSIDASE (Penicillium sp.) |
PF01301(Glyco_hydro_35)PF10435(BetaGal_dom2)PF13363(BetaGal_dom3)PF13364(BetaGal_dom4_5) | 5 | ALA A 338SER A 292ALA A 245PRO A 246VAL A 298 | None | 0.99A | 2zifB-1xc6A:2.1 | 2zifB-1xc6A:14.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yp4 | GLUCOSE-1-PHOSPHATEADENYLYLTRANSFERASESMALL SUBUNIT (Solanumtuberosum) |
PF00483(NTP_transferase) | 5 | ALA A 45PRO A 114GLY A 31THR A 32TYR A 35 | NoneNoneSO4 A1020 (-3.2A)SO4 A1020 (-4.2A)None | 1.03A | 2zifB-1yp4A:2.6 | 2zifB-1yp4A:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a7s | PROBABLEPROPIONYL-COACARBOXYLASE BETACHAIN 5 (Mycobacteriumtuberculosis) |
PF01039(Carboxyl_trans) | 5 | ALA A 252SER A 185ALA A 200PRO A 199THR A 247 | None | 1.18A | 2zifB-2a7sA:undetectable | 2zifB-2a7sA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d3t | FATTY OXIDATIONCOMPLEX ALPHASUBUNIT (Pseudomonasfragi) |
PF00378(ECH_1)PF00725(3HCDH)PF02737(3HCDH_N) | 5 | PRO A 384ALA A 317THR A 338LEU A 379VAL A 378 | None | 1.17A | 2zifB-2d3tA:undetectable | 2zifB-2d3tA:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e7u | GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE (Thermusthermophilus) |
PF00202(Aminotran_3) | 5 | PRO A 273GLY A 309THR A 312LEU A 304VAL A 77 | None | 1.06A | 2zifB-2e7uA:undetectable | 2zifB-2e7uA:23.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fpq | BOTULINUM NEUROTOXIND LIGHT CHAIN (Clostridiumbotulinum) |
PF01742(Peptidase_M27) | 5 | ALA A 36ALA A 195PRO A 196GLY A 160LEU A 157 | None | 1.01A | 2zifB-2fpqA:undetectable | 2zifB-2fpqA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h0a | TRANSCRIPTIONALREGULATOR (Thermusthermophilus) |
PF13377(Peripla_BP_3) | 5 | ALA A 169PRO A 326GLY A 281LEU A 328VAL A 329 | None | 1.19A | 2zifB-2h0aA:3.3 | 2zifB-2h0aA:25.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hg4 | 6-DEOXYERYTHRONOLIDEB SYNTHASE (Saccharopolysporaerythraea) |
PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF08990(Docking)PF16197(KAsynt_C_assoc) | 5 | SER A 212ALA A 192PRO A 191LEU A 269VAL A 268 | None | 1.18A | 2zifB-2hg4A:undetectable | 2zifB-2hg4A:17.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jms | PHEROMONE EN-6 (Euplotesnobilii) |
no annotation | 5 | ALA A 21PRO A 9PHE A 7GLY A 47THR A 46 | None | 1.19A | 2zifB-2jmsA:undetectable | 2zifB-2jmsA:10.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k3q | TUSP1 (Nephilaantipodiana) |
PF16763(Spidroin_N) | 5 | ALA A 30SER A 66ALA A 79PRO A 78VAL A 13 | None | 1.20A | 2zifB-2k3qA:undetectable | 2zifB-2k3qA:16.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mjp | PYROPHOSPHATASE (Methanocaldococcusjannaschii) |
PF01725(Ham1p_like) | 5 | ALA A 113PHE A 76GLY A 86THR A 87LEU A 81 | None | 1.21A | 2zifB-2mjpA:undetectable | 2zifB-2mjpA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o6x | SECRETED CATHEPSIN L1 (Fasciolahepatica) |
PF00112(Peptidase_C1)PF08246(Inhibitor_I29) | 5 | ALA A 231PHE A 126GLY A 130THR A 131VAL A 111 | None | 1.12A | 2zifB-2o6xA:undetectable | 2zifB-2o6xA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p6p | GLYCOSYL TRANSFERASE (Streptomycesfradiae) |
PF06722(DUF1205) | 5 | ALA A 124PRO A 165THR A 115LEU A 122TYR A 118 | None | 1.18A | 2zifB-2p6pA:2.9 | 2zifB-2p6pA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uyy | N-PAC PROTEIN (Homo sapiens) |
PF03446(NAD_binding_2)PF14833(NAD_binding_11) | 5 | ALA A 385SER A 414PHE A 417GLY A 421VAL A 400 | NoneNoneNone K A1554 (-4.2A)None | 1.13A | 2zifB-2uyyA:2.1 | 2zifB-2uyyA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vbi | PYRUVATEDECARBOXYLASE (Acetobacterpasteurianus) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | SER A 218PRO A 285ALA A 244VAL A 274TYR A 261 | None | 1.11A | 2zifB-2vbiA:undetectable | 2zifB-2vbiA:19.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zie | PUTATIVEMODIFICATIONMETHYLASE (Thermusthermophilus) |
PF01555(N6_N4_Mtase) | 7 | ALA A 29PRO A 219PHE A 220GLY A 245LEU A 265VAL A 266TYR A 269 | None | 0.92A | 2zifB-2zieA:38.4 | 2zifB-2zieA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zie | PUTATIVEMODIFICATIONMETHYLASE (Thermusthermophilus) |
PF01555(N6_N4_Mtase) | 10 | ALA A 29SER A 47PRO A 49PHE A 220PHE A 243GLY A 245THR A 246LEU A 265VAL A 266TYR A 269 | None | 0.38A | 2zifB-2zieA:38.4 | 2zifB-2zieA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zw4 | BLEOMYCINACETYLTRANSFERASE (Streptomycesverticillus) |
PF13302(Acetyltransf_3) | 5 | ALA A 212PRO A 217THR A 209LEU A 200VAL A 201 | None | 1.21A | 2zifB-2zw4A:undetectable | 2zifB-2zw4A:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zz8 | LIPL32 PROTEIN (Leptospirainterrogans) |
PF12103(Lipl32) | 5 | PRO A 81ALA A 209PHE A 195GLY A 42TYR A 41 | None | 1.02A | 2zifB-2zz8A:undetectable | 2zifB-2zz8A:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3csw | PUTATIVEBRANCHED-CHAIN-AMINO-ACIDAMINOTRANSFERASE (Thermotogamaritima) |
PF01063(Aminotran_4) | 5 | SER A 242PHE A 243GLY A 112THR A 111VAL A 233 | None | 1.11A | 2zifB-3cswA:undetectable | 2zifB-3cswA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cwc | PUTATIVE GLYCERATEKINASE 2 (Salmonellaenterica) |
PF02595(Gly_kinase) | 5 | ALA A 250PHE A 208GLY A 247LEU A 242VAL A 241 | None | 0.98A | 2zifB-3cwcA:undetectable | 2zifB-3cwcA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d7u | TYROSINE-PROTEINKINASE CSK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 316SER A 381PRO A 386ALA A 407PRO A 408 | None | 1.21A | 2zifB-3d7uA:undetectable | 2zifB-3d7uA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hid | ADENYLOSUCCINATESYNTHETASE (Yersinia pestis) |
PF00709(Adenylsucc_synt) | 5 | SER A 67PRO A 57LEU A 255VAL A 249TYR A 34 | None | 0.94A | 2zifB-3hidA:undetectable | 2zifB-3hidA:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j2j | PROTEIN VP1 (Enterovirus B) |
PF00073(Rhv) | 5 | ALA A 115PRO A 116GLY A 113LEU A 78VAL A 77 | None | 1.21A | 2zifB-3j2jA:undetectable | 2zifB-3j2jA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kcu | PROBABLE FORMATETRANSPORTER 1 (Escherichiacoli) |
PF01226(Form_Nir_trans) | 5 | ALA A 87GLY A 42THR A 40LEU A 122VAL A 123 | None | 1.19A | 2zifB-3kcuA:undetectable | 2zifB-3kcuA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kzw | CYTOSOLAMINOPEPTIDASE (Staphylococcusaureus) |
PF00883(Peptidase_M17)PF02789(Peptidase_M17_N) | 5 | ALA A 295ALA A 463GLY A 478THR A 477LEU A 178 | None | 1.21A | 2zifB-3kzwA:undetectable | 2zifB-3kzwA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mgk | INTRACELLULARPROTEASE/AMIDASERELATED ENZYME (THIJFAMILY) (Clostridiumacetobutylicum) |
PF01965(DJ-1_PfpI) | 5 | PHE A 13GLY A 71THR A 103LEU A 16VAL A 156 | None | 1.14A | 2zifB-3mgkA:undetectable | 2zifB-3mgkA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mq3 | PYRUVATEDEHYDROGENASEPHOSPHATASE 1 (Bos taurus) |
PF00481(PP2C) | 5 | ALA A 245ALA A 326PHE A 279GLY A 219THR A 218 | None | 1.17A | 2zifB-3mq3A:undetectable | 2zifB-3mq3A:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3muo | PROLYL ENDOPEPTIDASE (Aeromonascaviae) |
PF00326(Peptidase_S9)PF02897(Peptidase_S9_N) | 5 | SER A 149ALA A 655GLY A 660THR A 661LEU A 128 | None | 1.02A | 2zifB-3muoA:2.8 | 2zifB-3muoA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n2x | UNCHARACTERIZEDPROTEIN YAGE (Escherichiacoli) |
PF00701(DHDPS) | 5 | SER A 22PHE A 53GLY A 55LEU A 86VAL A 113 | NoneNoneMCL A 174 ( 3.2A)NoneNone | 1.16A | 2zifB-3n2xA:undetectable | 2zifB-3n2xA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n92 | ALPHA-AMYLASE, GH57FAMILY (Thermococcuskodakarensis) |
PF03065(Glyco_hydro_57)PF09210(DUF1957) | 5 | ALA A 351PRO A 352GLY A 266THR A 265LEU A 237 | None | 1.04A | 2zifB-3n92A:undetectable | 2zifB-3n92A:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nvx | PROTEIN A39 (Vaccinia virus) |
PF01403(Sema) | 5 | ALA A 159ALA A 103PRO A 104LEU A 120VAL A 119 | None | 1.07A | 2zifB-3nvxA:undetectable | 2zifB-3nvxA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qgm | P-NITROPHENYLPHOSPHATASE (PHO2) (Archaeoglobusfulgidus) |
PF13242(Hydrolase_like)PF13344(Hydrolase_6) | 5 | PRO A 249PHE A 253THR A 233LEU A 256VAL A 15 | None | 1.10A | 2zifB-3qgmA:3.9 | 2zifB-3qgmA:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ram | HMRA PROTEIN (Staphylococcusaureus) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | PRO A 126GLY A 99THR A 100LEU A 123VAL A 122 | None | 1.20A | 2zifB-3ramA:undetectable | 2zifB-3ramA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rh7 | HYPOTHETICALOXIDOREDUCTASE (Sinorhizobiummeliloti) |
PF01613(Flavin_Reduct) | 5 | ALA A 115ALA A 152GLY A 150LEU A 77TYR A 156 | None | 1.21A | 2zifB-3rh7A:undetectable | 2zifB-3rh7A:24.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT KNADH-QUINONEOXIDOREDUCTASESUBUNIT N (Escherichiacoli;Escherichiacoli) |
no annotationno annotation | 5 | SER N 168ALA K 41PHE K 15LEU K 64TYR K 62 | None | 1.19A | 2zifB-3rkoN:undetectable | 2zifB-3rkoN:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rpw | ABC TRANSPORTER (Rhodopseudomonaspalustris) |
PF13416(SBP_bac_8) | 5 | ALA A 44ALA A 320GLY A 239THR A 238TYR A 237 | NoneNoneGOL A 364 (-3.4A)NoneGOL A 364 (-4.2A) | 1.21A | 2zifB-3rpwA:undetectable | 2zifB-3rpwA:23.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sqg | METHYL COENZYME MREDUCTASE, ALPHASUBUNITMETHYL-COENZYME MREDUCTASE, BETASUBUNIT (unculturedarchaeon;unculturedarchaeon) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N)PF02241(MCR_beta)PF02783(MCR_beta_N) | 5 | ALA B 319PRO B 368PHE A 463GLY B 325VAL B 310 | None | 1.18A | 2zifB-3sqgB:undetectable | 2zifB-3sqgB:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t8l | ADENINE DEAMINASE 2 (Agrobacteriumfabrum) |
PF01979(Amidohydro_1)PF13382(Adenine_deam_C) | 5 | SER A 444ALA A 489PHE A 485GLY A 487VAL A 548 | None | 1.12A | 2zifB-3t8lA:undetectable | 2zifB-3t8lA:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tma | METHYLTRANSFERASE (Thermusthermophilus) |
PF01170(UPF0020)PF02926(THUMP) | 5 | ALA A 244PRO A 262PHE A 192GLY A 194LEU A 217 | None | 0.71A | 2zifB-3tmaA:4.0 | 2zifB-3tmaA:24.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3trr | PROBABLE ENOYL-COAHYDRATASE/ISOMERASE (Mycobacteroidesabscessus) |
PF00378(ECH_1) | 5 | ALA A 188PRO A 91ALA A 39PRO A 88PHE A 83 | None | 1.15A | 2zifB-3trrA:undetectable | 2zifB-3trrA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ujz | METALLOPROTEASE STCE (Escherichiacoli) |
PF10462(Peptidase_M66) | 5 | ALA A 317PRO A 342ALA A 787PRO A 788GLY A 711 | None | 1.19A | 2zifB-3ujzA:undetectable | 2zifB-3ujzA:16.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wwp | (S)-HYDROXYNITRILELYASE (Baliospermummontanum) |
PF00561(Abhydrolase_1) | 5 | ALA A 90PRO A 108GLY A 82THR A 11LEU A 88 | NoneNoneNoneEDO A 302 ( 2.9A)None | 1.15A | 2zifB-3wwpA:undetectable | 2zifB-3wwpA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cnk | L-AMINO ACID OXIDASE (Streptococcuscristatus) |
PF03486(HI0933_like) | 5 | ALA A 192PRO A 196GLY A 325THR A 324VAL A 246 | None | 1.10A | 2zifB-4cnkA:undetectable | 2zifB-4cnkA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cok | PYRUVATEDECARBOXYLASE (Gluconacetobacterdiazotrophicus) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | SER A 218PRO A 285ALA A 244VAL A 274TYR A 261 | None | 1.07A | 2zifB-4cokA:undetectable | 2zifB-4cokA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eei | ADENYLOSUCCINATELYASE (Francisellatularensis) |
PF00206(Lyase_1) | 5 | ALA A 220SER A 286ALA A 281GLY A 227LEU A 222 | None | 1.10A | 2zifB-4eeiA:undetectable | 2zifB-4eeiA:19.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f5x | RNA-DIRECTED RNAPOLYMERASE (Rotavirus A) |
PF02123(RdRP_4)PF12289(Rotavirus_VP1) | 5 | ALA W 603SER W 522ALA W 678GLY W 630LEU W 605 | None | 1.13A | 2zifB-4f5xW:undetectable | 2zifB-4f5xW:14.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jhm | MANDELATE RACEMASE /MUCONATE LACTONIZINGENZYME, C-TERMINALDOMAIN PROTEIN (Pseudovibriosp. JE062) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 329ALA A 306PHE A 321PHE A 330LEU A 332 | None | 1.17A | 2zifB-4jhmA:undetectable | 2zifB-4jhmA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jq9 | DIHYDROLIPOYLDEHYDROGENASE (Escherichiacoli) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ALA A 266GLY A 191THR A 192LEU A 179VAL A 203 | None | 1.10A | 2zifB-4jq9A:undetectable | 2zifB-4jq9A:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nec | PUTATIVESAM-DEPENDENTMETHYLTRANSFERASE (Streptomyceslasaliensis) |
PF13649(Methyltransf_25) | 5 | ALA A 95SER A 111GLY A 49THR A 50LEU A 69 | SAH A 401 (-3.2A)SAH A 401 (-3.3A)SAH A 401 (-3.6A)NoneSAH A 401 (-3.7A) | 0.68A | 2zifB-4necA:5.0 | 2zifB-4necA:23.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oe7 | PROBABLE2-KETO-3-DEOXY-GALACTONATE ALDOLASE YAGE (Escherichiacoli) |
PF00701(DHDPS) | 5 | SER A 22PHE A 53GLY A 55LEU A 86VAL A 113 | NoneNonePYR A 410 (-3.2A)NoneNone | 1.20A | 2zifB-4oe7A:undetectable | 2zifB-4oe7A:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p3m | SERINEHYDROXYMETHYLTRANSFERASE (Psychromonasingrahamii) |
PF00464(SHMT) | 5 | SER A 311ALA A 295GLY A 365THR A 366VAL A 344 | None | 1.06A | 2zifB-4p3mA:undetectable | 2zifB-4p3mA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qid | BACTERIORHODOPSIN-I (Haloquadratumwalsbyi) |
PF01036(Bac_rhodopsin) | 5 | ALA A 111ALA A 181PHE A 164THR A 178LEU A 107 | None | 1.17A | 2zifB-4qidA:undetectable | 2zifB-4qidA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r27 | GLYCOSIDE HYDROLASE (Microbacteriumsp. Gsoil167) |
PF00232(Glyco_hydro_1) | 5 | ALA A 230PRO A 173GLY A 223THR A 220LEU A 228 | None | 1.19A | 2zifB-4r27A:undetectable | 2zifB-4r27A:24.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rku | PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A2 (Pisum sativum) |
PF00223(PsaA_PsaB) | 5 | SER B 666GLY B 660THR B 659LEU B 710VAL B 711 | PQN B5002 (-3.2A)NoneCLA B9023 ( 3.7A)NoneCLA B1239 ( 4.0A) | 1.09A | 2zifB-4rkuB:undetectable | 2zifB-4rkuB:16.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xqk | LLABIII (Lactococcuslactis) |
PF00271(Helicase_C)PF02384(N6_Mtase)PF04851(ResIII)PF13156(Mrr_cat_2) | 6 | PRO A1020PHE A 910PHE A 904GLY A 906THR A 907VAL A 946 | None | 1.31A | 2zifB-4xqkA:2.2 | 2zifB-4xqkA:11.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zhj | MG-CHELATASE SUBUNITCHLH (Synechocystissp. PCC 6803) |
PF02514(CobN-Mg_chel)PF11965(DUF3479) | 5 | ALA A 913ALA A 655GLY A 937THR A 936LEU A 910 | None | 0.91A | 2zifB-4zhjA:undetectable | 2zifB-4zhjA:12.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zi5 | P91 (metagenome) |
PF01738(DLH) | 5 | ALA A 59ALA A 68GLY A 17LEU A 101TYR A 8 | None | 1.20A | 2zifB-4zi5A:2.1 | 2zifB-4zi5A:23.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a2o | NITRATE TRANSPORTER1.1 (Arabidopsisthaliana) |
PF00854(PTR2) | 5 | ALA A 397GLY A 473LEU A 393VAL A 389TYR A 388 | None | 1.17A | 2zifB-5a2oA:undetectable | 2zifB-5a2oA:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b1u | METALLO-BETA-LACTAMASE (Serratiamarcescens) |
PF00753(Lactamase_B) | 5 | ALA A 94SER A 82ALA A 48GLY A 42LEU A 69 | NA A 304 (-3.6A) NA A 305 (-3.2A)NoneNoneNone | 1.08A | 2zifB-5b1uA:undetectable | 2zifB-5b1uA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b1u | METALLO-BETA-LACTAMASE (Serratiamarcescens) |
PF00753(Lactamase_B) | 5 | ALA A 94SER A 82GLY A 42THR A 43LEU A 69 | NA A 304 (-3.6A) NA A 305 (-3.2A)NoneNoneNone | 1.07A | 2zifB-5b1uA:undetectable | 2zifB-5b1uA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bqn | BOTULINUM NEUROTOXINTYPE D,BOTULINUMNEUROTOXIN TYPE D (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07952(Toxin_trans) | 5 | ALA A 36ALA A 195PRO A 196GLY A 160LEU A 157 | None | 1.13A | 2zifB-5bqnA:undetectable | 2zifB-5bqnA:15.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ejj | UFM1-SPECIFICPROTEASE (Caenorhabditiselegans) |
PF07910(Peptidase_C78) | 5 | PRO A 501ALA A 492GLY A 515LEU A 530VAL A 529 | None | 1.11A | 2zifB-5ejjA:undetectable | 2zifB-5ejjA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ex8 | CYTOCHROME P450 (Streptomycestoyocaensis) |
PF00067(p450) | 5 | PHE A 186PHE A 228GLY A 224THR A 223LEU A 85 | NoneEDO A 402 (-4.2A)EDO A 415 (-3.7A)EDO A 415 ( 4.3A)HEM A 401 (-3.9A) | 1.20A | 2zifB-5ex8A:undetectable | 2zifB-5ex8A:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fby | SEPARASE (Chaetomiumthermophilum) |
PF03568(Peptidase_C50) | 5 | PRO A2076ALA A2137PRO A2136LEU A2021VAL A2163 | None | 1.03A | 2zifB-5fbyA:undetectable | 2zifB-5fbyA:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ffj | ENDONUCLEASE ANDMETHYLASE LLAGI (Lactococcuslactis) |
PF00271(Helicase_C)PF02384(N6_Mtase)PF04851(ResIII) | 6 | PRO A1020PHE A 910PHE A 904GLY A 906THR A 907VAL A 946 | None | 1.21A | 2zifB-5ffjA:2.0 | 2zifB-5ffjA:12.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fyg | CYTOCHROME P450 (Marinobacterhydrocarbonoclasticus) |
PF00067(p450) | 5 | ALA A 326SER A 349ALA A 428THR A 316LEU A 324 | NoneNoneHEM A1475 (-3.5A)HEM A1475 (-4.5A)None | 1.21A | 2zifB-5fygA:undetectable | 2zifB-5fygA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5grh | ISOCITRATEDEHYDROGENASE [NAD]SUBUNIT GAMMA,MITOCHONDRIAL (Homo sapiens) |
PF00180(Iso_dh) | 5 | ALA B 265SER B 293ALA B 288GLY B 257VAL B 106 | None | 1.17A | 2zifB-5grhB:undetectable | 2zifB-5grhB:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5grj | AVELUMAB H CHAINAVELUMAB L CHAIN (Homo sapiens;Homo sapiens) |
PF07686(V-set)PF07686(V-set) | 5 | ALA H 92ALA L 45PRO L 46GLY H 113LEU H 115 | None | 1.19A | 2zifB-5grjH:undetectable | 2zifB-5grjH:15.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hfj | ADENINE SPECIFIC DNAMETHYLTRANSFERASE(DPNA) (Helicobacterpylori) |
PF01555(N6_N4_Mtase) | 5 | ALA A 9PRO A 31PHE A 195GLY A 197TYR A 221 | SAM A 301 (-3.2A)SAM A 301 ( 4.0A)SAM A 301 (-4.6A)SAM A 301 (-3.4A)SAM A 301 (-4.2A) | 0.43A | 2zifB-5hfjA:19.9 | 2zifB-5hfjA:26.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i92 | GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE (Pseudomonasaeruginosa) |
PF00202(Aminotran_3) | 5 | PRO A 272GLY A 308THR A 311LEU A 303VAL A 75 | None | 1.18A | 2zifB-5i92A:undetectable | 2zifB-5i92A:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k1u | NAD(P)H:FLAVINOXIDOREDUCTASE SYE4 (Shewanellaoneidensis) |
PF00724(Oxidored_FMN) | 5 | ALA A 131ALA A 73PHE A 121GLY A 113THR A 112 | None | 1.10A | 2zifB-5k1uA:2.7 | 2zifB-5k1uA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l1t | PENTALENOLACTONESYNTHASE (Streptomycesarenae) |
PF00067(p450) | 5 | PHE A 391GLY A 244THR A 245LEU A 273VAL A 269 | None | 1.20A | 2zifB-5l1tA:undetectable | 2zifB-5l1tA:24.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mg5 | 2,4-DIACETYLPHLOROGLUCINOL BIOSYNTHESISPROTEIN PHLC (Pseudomonasprotegens) |
no annotation | 5 | ALA C 147SER C 131ALA C 86GLY C 384THR C 89 | NoneNoneNoneSCY C 88 ( 3.5A)SCY C 88 ( 3.8A) | 1.21A | 2zifB-5mg5C:undetectable | 2zifB-5mg5C:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5min | QUINOPROTEIN GLUCOSEDEHYDROGENASE B (Acinetobactercalcoaceticus) |
no annotation | 5 | SER A 244ALA A 350PRO A 351THR A 348TYR A 325 | None CA A 503 ( 3.9A)NoneNoneNone | 1.06A | 2zifB-5minA:undetectable | 2zifB-5minA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tdx | ANCESTRALHYDROXYNITRILE LYASE1 (syntheticconstruct) |
no annotation | 5 | ALA A 90PRO A 108GLY A 82THR A 11LEU A 88 | NoneNoneNoneGOL A 300 (-2.9A)None | 0.98A | 2zifB-5tdxA:2.0 | 2zifB-5tdxA:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5txe | ATXE2 (Asticcacaulisexcentricus) |
PF00326(Peptidase_S9) | 5 | ALA A 54SER A 440PHE A 416GLY A 349THR A 348 | None | 1.13A | 2zifB-5txeA:2.1 | 2zifB-5txeA:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5van | BETA-KLOTHO (Homo sapiens) |
no annotation | 5 | ALA A 399PHE A 374GLY A 301VAL A 326TYR A 243 | None | 1.09A | 2zifB-5vanA:undetectable | 2zifB-5vanA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vmb | SERINEHYDROXYMETHYLTRANSFERASE (Acinetobacterbaumannii) |
PF00464(SHMT) | 5 | SER A 178ALA A 294GLY A 364THR A 365VAL A 343 | None | 0.92A | 2zifB-5vmbA:undetectable | 2zifB-5vmbA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xfa | NAD-REDUCINGHYDROGENASE (Hydrogenophilusthermoluteolus) |
PF00374(NiFeSe_Hases) | 5 | ALA D 178SER D 86PRO D 84PRO D 395GLY D 118 | NoneNoneNoneFCO D 501 ( 3.8A)None | 1.03A | 2zifB-5xfaD:undetectable | 2zifB-5xfaD:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yu1 | LYSINECYCLODEAMINASE (Streptomycespristinaespiralis) |
no annotation | 5 | ALA A 311SER A 126PHE A 299GLY A 303THR A 302 | NoneNoneNoneNAD A 402 ( 3.2A)None | 1.17A | 2zifB-5yu1A:undetectable | 2zifB-5yu1A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6e0s | - (-) |
no annotation | 5 | ALA A 113SER A 101ALA A 67GLY A 61LEU A 88 | None | 1.10A | 2zifB-6e0sA:undetectable | 2zifB-6e0sA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f74 | ALCOHOL OXIDASE (Thermothelomycesthermophila) |
no annotation | 5 | SER A 423PRO A 232ALA A 249PRO A 248VAL A 215 | None | 1.21A | 2zifB-6f74A:undetectable | 2zifB-6f74A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fos | PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A2 (Cyanidioschyzonmerolae) |
no annotation | 5 | SER B 664GLY B 658THR B 657LEU B 708VAL B 709 | CLA B1023 (-4.5A)NoneCLA B1239 ( 4.4A)NoneCLA B1226 (-4.4A) | 1.12A | 2zifB-6fosB:undetectable | 2zifB-6fosB:undetectable |