SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZIF_B_SAMB298

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avw TRYPSIN INHIBITOR

(Glycine max) 		PF00197
(Kunitz_legume) 		6 ALA B 531
SER B 579
PHE B 580
GLY B 555
THR B 516
TYR B 518
 None
 1.31A 2zifB-1avwB:
undetectable		 2zifB-1avwB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhy P64K

(Neisseria
meningitidis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 393
GLY A 317
THR A 318
LEU A 305
VAL A 329
 None
 1.16A 2zifB-1bhyA:
undetectable		 2zifB-1bhyA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris) 		PF01555
(N6_N4_Mtase) 		6 SER A  53
PRO A  55
PHE A 250
PHE A 273
GLY A 275
TYR A 299
 SAH  A 401 (-3.4A)
SAH  A 401 (-3.9A)
SAH  A 401 (-3.4A)
SAH  A 401 (-4.6A)
SAH  A 401 (-3.5A)
SAH  A 401 (-4.2A)
 0.65A 2zifB-1booA:
22.2		 2zifB-1booA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		5 SER A  98
GLY A  65
THR A  66
LEU A  31
VAL A  30
 None
 1.17A 2zifB-1c3lA:
undetectable		 2zifB-1c3lA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4m PROTEIN
(COXSACKIEVIRUS A9)

(Enterovirus B) 		PF00073
(Rhv) 		5 ALA 1 177
PRO 1 178
GLY 1 175
LEU 1 140
VAL 1 139
 None
 1.21A 2zifB-1d4m1:
undetectable		 2zifB-1d4m1:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5f METHIONINE
GAMMA-LYASE

(Trichomonas
vaginalis) 		PF01053
(Cys_Met_Meta_PP) 		5 ALA A 275
ALA A 157
PRO A 156
THR A 160
LEU A 374
 None
 1.00A 2zifB-1e5fA:
undetectable		 2zifB-1e5fA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epv ALANINE RACEMASE

(Geobacillus
stearothermophilus) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 ALA A  54
SER A 204
ALA A 228
PRO A 229
GLY A 226
 None
DCS  A1001 (-1.9A)
None
None
None
 1.20A 2zifB-1epvA:
undetectable		 2zifB-1epvA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpg GLUTAMIC ACID
SPECIFIC PROTEASE

(Streptomyces
griseus) 		no annotation 5 ALA A 226
SER A 139
ALA A  44
GLY A 196
THR A  54
 None
 1.07A 2zifB-1hpgA:
undetectable		 2zifB-1hpgA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		5 PRO A 594
PRO A 576
PHE A 577
GLY A 662
LEU A 659
 None
 1.17A 2zifB-1hwwA:
undetectable		 2zifB-1hwwA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		5 ALA A 286
GLY A 253
THR A 254
LEU A 282
VAL A 278
 None
 1.17A 2zifB-1jioA:
undetectable		 2zifB-1jioA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jtd BETA-LACTAMASE
INHIBITOR PROTEIN II

(Streptomyces
exfoliatus) 		PF13540
(RCC1_2) 		5 ALA B 110
SER B 266
PRO B 303
GLY B 189
THR B 192
 None
None
None
CA  B 502 ( 4.9A)
None
 1.13A 2zifB-1jtdB:
undetectable		 2zifB-1jtdB:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 316
SER A 381
PRO A 386
ALA A 407
PRO A 408
 None
 1.21A 2zifB-1k9aA:
undetectable		 2zifB-1k9aA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE

(Escherichia
coli) 		PF13406
(SLT_2) 		5 ALA A 218
SER A 193
ALA A  60
PHE A  63
PHE A 192
 EDO  A 402 ( 3.8A)
None
None
None
None
 1.09A 2zifB-1ltmA:
undetectable		 2zifB-1ltmA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m72 CASPASE-1

(Spodoptera
frugiperda) 		PF00656
(Peptidase_C14) 		5 ALA A 126
ALA A 208
PHE A 210
GLY A 168
VAL A  46
 None
 1.14A 2zifB-1m72A:
undetectable		 2zifB-1m72A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdz ENOLASE

(Homarus
gammarus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ALA A 431
PRO A 432
GLY A 367
LEU A 342
VAL A 317
 None
 1.02A 2zifB-1pdzA:
undetectable		 2zifB-1pdzA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q9h CELLOBIOHYDROLASE I
CATALYTIC DOMAIN

(Rasamsonia
emersonii) 		PF00840
(Glyco_hydro_7) 		5 SER A 112
ALA A 160
GLY A 165
THR A 166
LEU A 105
 None
PCA  A   1 ( 3.7A)
None
None
None
 1.21A 2zifB-1q9hA:
undetectable		 2zifB-1q9hA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 ALA A 338
SER A 292
ALA A 245
PRO A 246
VAL A 298
 None
 0.99A 2zifB-1xc6A:
2.1		 2zifB-1xc6A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp4 GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
SMALL SUBUNIT

(Solanum
tuberosum) 		PF00483
(NTP_transferase) 		5 ALA A  45
PRO A 114
GLY A  31
THR A  32
TYR A  35
 None
None
SO4  A1020 (-3.2A)
SO4  A1020 (-4.2A)
None
 1.03A 2zifB-1yp4A:
2.6		 2zifB-1yp4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		5 ALA A 252
SER A 185
ALA A 200
PRO A 199
THR A 247
 None
 1.18A 2zifB-2a7sA:
undetectable		 2zifB-2a7sA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 PRO A 384
ALA A 317
THR A 338
LEU A 379
VAL A 378
 None
 1.17A 2zifB-2d3tA:
undetectable		 2zifB-2d3tA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		5 PRO A 273
GLY A 309
THR A 312
LEU A 304
VAL A  77
 None
 1.06A 2zifB-2e7uA:
undetectable		 2zifB-2e7uA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpq BOTULINUM NEUROTOXIN
D LIGHT CHAIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		5 ALA A  36
ALA A 195
PRO A 196
GLY A 160
LEU A 157
 None
 1.01A 2zifB-2fpqA:
undetectable		 2zifB-2fpqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0a TRANSCRIPTIONAL
REGULATOR

(Thermus
thermophilus) 		PF13377
(Peripla_BP_3) 		5 ALA A 169
PRO A 326
GLY A 281
LEU A 328
VAL A 329
 None
 1.19A 2zifB-2h0aA:
3.3		 2zifB-2h0aA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		5 SER A 212
ALA A 192
PRO A 191
LEU A 269
VAL A 268
 None
 1.18A 2zifB-2hg4A:
undetectable		 2zifB-2hg4A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jms PHEROMONE EN-6

(Euplotes
nobilii) 		no annotation 5 ALA A  21
PRO A   9
PHE A   7
GLY A  47
THR A  46
 None
 1.19A 2zifB-2jmsA:
undetectable		 2zifB-2jmsA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k3q TUSP1

(Nephila
antipodiana) 		PF16763
(Spidroin_N) 		5 ALA A  30
SER A  66
ALA A  79
PRO A  78
VAL A  13
 None
 1.20A 2zifB-2k3qA:
undetectable		 2zifB-2k3qA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mjp PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01725
(Ham1p_like) 		5 ALA A 113
PHE A  76
GLY A  86
THR A  87
LEU A  81
 None
 1.21A 2zifB-2mjpA:
undetectable		 2zifB-2mjpA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6x SECRETED CATHEPSIN L
1

(Fasciola
hepatica) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		5 ALA A 231
PHE A 126
GLY A 130
THR A 131
VAL A 111
 None
 1.12A 2zifB-2o6xA:
undetectable		 2zifB-2o6xA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6p GLYCOSYL TRANSFERASE

(Streptomyces
fradiae) 		PF06722
(DUF1205) 		5 ALA A 124
PRO A 165
THR A 115
LEU A 122
TYR A 118
 None
 1.18A 2zifB-2p6pA:
2.9		 2zifB-2p6pA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyy N-PAC PROTEIN

(Homo sapiens) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 ALA A 385
SER A 414
PHE A 417
GLY A 421
VAL A 400
 None
None
None
K  A1554 (-4.2A)
None
 1.13A 2zifB-2uyyA:
2.1		 2zifB-2uyyA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbi PYRUVATE
DECARBOXYLASE

(Acetobacter
pasteurianus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 SER A 218
PRO A 285
ALA A 244
VAL A 274
TYR A 261
 None
 1.11A 2zifB-2vbiA:
undetectable		 2zifB-2vbiA:
19.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zie PUTATIVE
MODIFICATION
METHYLASE

(Thermus
thermophilus) 		PF01555
(N6_N4_Mtase) 		7 ALA A  29
PRO A 219
PHE A 220
GLY A 245
LEU A 265
VAL A 266
TYR A 269
 None
 0.92A 2zifB-2zieA:
38.4		 2zifB-2zieA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zie PUTATIVE
MODIFICATION
METHYLASE

(Thermus
thermophilus) 		PF01555
(N6_N4_Mtase) 		10 ALA A  29
SER A  47
PRO A  49
PHE A 220
PHE A 243
GLY A 245
THR A 246
LEU A 265
VAL A 266
TYR A 269
 None
 0.38A 2zifB-2zieA:
38.4		 2zifB-2zieA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zw4 BLEOMYCIN
ACETYLTRANSFERASE

(Streptomyces
verticillus) 		PF13302
(Acetyltransf_3) 		5 ALA A 212
PRO A 217
THR A 209
LEU A 200
VAL A 201
 None
 1.21A 2zifB-2zw4A:
undetectable		 2zifB-2zw4A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zz8 LIPL32 PROTEIN

(Leptospira
interrogans) 		PF12103
(Lipl32) 		5 PRO A  81
ALA A 209
PHE A 195
GLY A  42
TYR A  41
 None
 1.02A 2zifB-2zz8A:
undetectable		 2zifB-2zz8A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF01063
(Aminotran_4) 		5 SER A 242
PHE A 243
GLY A 112
THR A 111
VAL A 233
 None
 1.11A 2zifB-3cswA:
undetectable		 2zifB-3cswA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwc PUTATIVE GLYCERATE
KINASE 2

(Salmonella
enterica) 		PF02595
(Gly_kinase) 		5 ALA A 250
PHE A 208
GLY A 247
LEU A 242
VAL A 241
 None
 0.98A 2zifB-3cwcA:
undetectable		 2zifB-3cwcA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 316
SER A 381
PRO A 386
ALA A 407
PRO A 408
 None
 1.21A 2zifB-3d7uA:
undetectable		 2zifB-3d7uA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hid ADENYLOSUCCINATE
SYNTHETASE

(Yersinia pestis) 		PF00709
(Adenylsucc_synt) 		5 SER A  67
PRO A  57
LEU A 255
VAL A 249
TYR A  34
 None
 0.94A 2zifB-3hidA:
undetectable		 2zifB-3hidA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2j PROTEIN VP1

(Enterovirus B) 		PF00073
(Rhv) 		5 ALA A 115
PRO A 116
GLY A 113
LEU A  78
VAL A  77
 None
 1.21A 2zifB-3j2jA:
undetectable		 2zifB-3j2jA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcu PROBABLE FORMATE
TRANSPORTER 1

(Escherichia
coli) 		PF01226
(Form_Nir_trans) 		5 ALA A  87
GLY A  42
THR A  40
LEU A 122
VAL A 123
 None
 1.19A 2zifB-3kcuA:
undetectable		 2zifB-3kcuA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzw CYTOSOL
AMINOPEPTIDASE

(Staphylococcus
aureus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 ALA A 295
ALA A 463
GLY A 478
THR A 477
LEU A 178
 None
 1.21A 2zifB-3kzwA:
undetectable		 2zifB-3kzwA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgk INTRACELLULAR
PROTEASE/AMIDASE
RELATED ENZYME (THIJ
FAMILY)

(Clostridium
acetobutylicum) 		PF01965
(DJ-1_PfpI) 		5 PHE A  13
GLY A  71
THR A 103
LEU A  16
VAL A 156
 None
 1.14A 2zifB-3mgkA:
undetectable		 2zifB-3mgkA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1

(Bos taurus) 		PF00481
(PP2C) 		5 ALA A 245
ALA A 326
PHE A 279
GLY A 219
THR A 218
 None
 1.17A 2zifB-3mq3A:
undetectable		 2zifB-3mq3A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muo PROLYL ENDOPEPTIDASE

(Aeromonas
caviae) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 SER A 149
ALA A 655
GLY A 660
THR A 661
LEU A 128
 None
 1.02A 2zifB-3muoA:
2.8		 2zifB-3muoA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2x UNCHARACTERIZED
PROTEIN YAGE

(Escherichia
coli) 		PF00701
(DHDPS) 		5 SER A  22
PHE A  53
GLY A  55
LEU A  86
VAL A 113
 None
None
MCL  A 174 ( 3.2A)
None
None
 1.16A 2zifB-3n2xA:
undetectable		 2zifB-3n2xA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n92 ALPHA-AMYLASE, GH57
FAMILY

(Thermococcus
kodakarensis) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		5 ALA A 351
PRO A 352
GLY A 266
THR A 265
LEU A 237
 None
 1.04A 2zifB-3n92A:
undetectable		 2zifB-3n92A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvx PROTEIN A39

(Vaccinia virus) 		PF01403
(Sema) 		5 ALA A 159
ALA A 103
PRO A 104
LEU A 120
VAL A 119
 None
 1.07A 2zifB-3nvxA:
undetectable		 2zifB-3nvxA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgm P-NITROPHENYL
PHOSPHATASE (PHO2)

(Archaeoglobus
fulgidus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 PRO A 249
PHE A 253
THR A 233
LEU A 256
VAL A  15
 None
 1.10A 2zifB-3qgmA:
3.9		 2zifB-3qgmA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ram HMRA PROTEIN

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 PRO A 126
GLY A  99
THR A 100
LEU A 123
VAL A 122
 None
 1.20A 2zifB-3ramA:
undetectable		 2zifB-3ramA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh7 HYPOTHETICAL
OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF01613
(Flavin_Reduct) 		5 ALA A 115
ALA A 152
GLY A 150
LEU A  77
TYR A 156
 None
 1.21A 2zifB-3rh7A:
undetectable		 2zifB-3rh7A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli;
Escherichia
coli) 		no annotation
no annotation 		5 SER N 168
ALA K  41
PHE K  15
LEU K  64
TYR K  62
 None
 1.19A 2zifB-3rkoN:
undetectable		 2zifB-3rkoN:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpw ABC TRANSPORTER

(Rhodopseudomonas
palustris) 		PF13416
(SBP_bac_8) 		5 ALA A  44
ALA A 320
GLY A 239
THR A 238
TYR A 237
 None
None
GOL  A 364 (-3.4A)
None
GOL  A 364 (-4.2A)
 1.21A 2zifB-3rpwA:
undetectable		 2zifB-3rpwA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT

(uncultured
archaeon;
uncultured
archaeon) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 ALA B 319
PRO B 368
PHE A 463
GLY B 325
VAL B 310
 None
 1.18A 2zifB-3sqgB:
undetectable		 2zifB-3sqgB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8l ADENINE DEAMINASE 2

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1)
PF13382
(Adenine_deam_C) 		5 SER A 444
ALA A 489
PHE A 485
GLY A 487
VAL A 548
 None
 1.12A 2zifB-3t8lA:
undetectable		 2zifB-3t8lA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tma METHYLTRANSFERASE

(Thermus
thermophilus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		5 ALA A 244
PRO A 262
PHE A 192
GLY A 194
LEU A 217
 None
 0.71A 2zifB-3tmaA:
4.0		 2zifB-3tmaA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trr PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		5 ALA A 188
PRO A  91
ALA A  39
PRO A  88
PHE A  83
 None
 1.15A 2zifB-3trrA:
undetectable		 2zifB-3trrA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujz METALLOPROTEASE STCE

(Escherichia
coli) 		PF10462
(Peptidase_M66) 		5 ALA A 317
PRO A 342
ALA A 787
PRO A 788
GLY A 711
 None
 1.19A 2zifB-3ujzA:
undetectable		 2zifB-3ujzA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwp (S)-HYDROXYNITRILE
LYASE

(Baliospermum
montanum) 		PF00561
(Abhydrolase_1) 		5 ALA A  90
PRO A 108
GLY A  82
THR A  11
LEU A  88
 None
None
None
EDO  A 302 ( 2.9A)
None
 1.15A 2zifB-3wwpA:
undetectable		 2zifB-3wwpA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnk L-AMINO ACID OXIDASE

(Streptococcus
cristatus) 		PF03486
(HI0933_like) 		5 ALA A 192
PRO A 196
GLY A 325
THR A 324
VAL A 246
 None
 1.10A 2zifB-4cnkA:
undetectable		 2zifB-4cnkA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cok PYRUVATE
DECARBOXYLASE

(Gluconacetobacter
diazotrophicus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 SER A 218
PRO A 285
ALA A 244
VAL A 274
TYR A 261
 None
 1.07A 2zifB-4cokA:
undetectable		 2zifB-4cokA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eei ADENYLOSUCCINATE
LYASE

(Francisella
tularensis) 		PF00206
(Lyase_1) 		5 ALA A 220
SER A 286
ALA A 281
GLY A 227
LEU A 222
 None
 1.10A 2zifB-4eeiA:
undetectable		 2zifB-4eeiA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		5 ALA W 603
SER W 522
ALA W 678
GLY W 630
LEU W 605
 None
 1.13A 2zifB-4f5xW:
undetectable		 2zifB-4f5xW:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhm MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN

(Pseudovibrio
sp. JE062) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 329
ALA A 306
PHE A 321
PHE A 330
LEU A 332
 None
 1.17A 2zifB-4jhmA:
undetectable		 2zifB-4jhmA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jq9 DIHYDROLIPOYL
DEHYDROGENASE

(Escherichia
coli) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 266
GLY A 191
THR A 192
LEU A 179
VAL A 203
 None
 1.10A 2zifB-4jq9A:
undetectable		 2zifB-4jq9A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nec PUTATIVE
SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
lasaliensis) 		PF13649
(Methyltransf_25) 		5 ALA A  95
SER A 111
GLY A  49
THR A  50
LEU A  69
 SAH  A 401 (-3.2A)
SAH  A 401 (-3.3A)
SAH  A 401 (-3.6A)
None
SAH  A 401 (-3.7A)
 0.68A 2zifB-4necA:
5.0		 2zifB-4necA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE

(Escherichia
coli) 		PF00701
(DHDPS) 		5 SER A  22
PHE A  53
GLY A  55
LEU A  86
VAL A 113
 None
None
PYR  A 410 (-3.2A)
None
None
 1.20A 2zifB-4oe7A:
undetectable		 2zifB-4oe7A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Psychromonas
ingrahamii) 		PF00464
(SHMT) 		5 SER A 311
ALA A 295
GLY A 365
THR A 366
VAL A 344
 None
 1.06A 2zifB-4p3mA:
undetectable		 2zifB-4p3mA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qid BACTERIORHODOPSIN-I

(Haloquadratum
walsbyi) 		PF01036
(Bac_rhodopsin) 		5 ALA A 111
ALA A 181
PHE A 164
THR A 178
LEU A 107
 None
 1.17A 2zifB-4qidA:
undetectable		 2zifB-4qidA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r27 GLYCOSIDE HYDROLASE

(Microbacterium
sp. Gsoil167) 		PF00232
(Glyco_hydro_1) 		5 ALA A 230
PRO A 173
GLY A 223
THR A 220
LEU A 228
 None
 1.19A 2zifB-4r27A:
undetectable		 2zifB-4r27A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		5 SER B 666
GLY B 660
THR B 659
LEU B 710
VAL B 711
 PQN  B5002 (-3.2A)
None
CLA  B9023 ( 3.7A)
None
CLA  B1239 ( 4.0A)
 1.09A 2zifB-4rkuB:
undetectable		 2zifB-4rkuB:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		6 PRO A1020
PHE A 910
PHE A 904
GLY A 906
THR A 907
VAL A 946
 None
 1.31A 2zifB-4xqkA:
2.2		 2zifB-4xqkA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		5 ALA A 913
ALA A 655
GLY A 937
THR A 936
LEU A 910
 None
 0.91A 2zifB-4zhjA:
undetectable		 2zifB-4zhjA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi5 P91

(metagenome) 		PF01738
(DLH) 		5 ALA A  59
ALA A  68
GLY A  17
LEU A 101
TYR A   8
 None
 1.20A 2zifB-4zi5A:
2.1		 2zifB-4zi5A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2o NITRATE TRANSPORTER
1.1

(Arabidopsis
thaliana) 		PF00854
(PTR2) 		5 ALA A 397
GLY A 473
LEU A 393
VAL A 389
TYR A 388
 None
 1.17A 2zifB-5a2oA:
undetectable		 2zifB-5a2oA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1u METALLO-BETA-LACTAMA
SE

(Serratia
marcescens) 		PF00753
(Lactamase_B) 		5 ALA A  94
SER A  82
ALA A  48
GLY A  42
LEU A  69
 NA  A 304 (-3.6A)
NA  A 305 (-3.2A)
None
None
None
 1.08A 2zifB-5b1uA:
undetectable		 2zifB-5b1uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1u METALLO-BETA-LACTAMA
SE

(Serratia
marcescens) 		PF00753
(Lactamase_B) 		5 ALA A  94
SER A  82
GLY A  42
THR A  43
LEU A  69
 NA  A 304 (-3.6A)
NA  A 305 (-3.2A)
None
None
None
 1.07A 2zifB-5b1uA:
undetectable		 2zifB-5b1uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqn BOTULINUM NEUROTOXIN
TYPE D,BOTULINUM
NEUROTOXIN TYPE D

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		5 ALA A  36
ALA A 195
PRO A 196
GLY A 160
LEU A 157
 None
 1.13A 2zifB-5bqnA:
undetectable		 2zifB-5bqnA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejj UFM1-SPECIFIC
PROTEASE

(Caenorhabditis
elegans) 		PF07910
(Peptidase_C78) 		5 PRO A 501
ALA A 492
GLY A 515
LEU A 530
VAL A 529
 None
 1.11A 2zifB-5ejjA:
undetectable		 2zifB-5ejjA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex8 CYTOCHROME P450

(Streptomyces
toyocaensis) 		PF00067
(p450) 		5 PHE A 186
PHE A 228
GLY A 224
THR A 223
LEU A  85
 None
EDO  A 402 (-4.2A)
EDO  A 415 (-3.7A)
EDO  A 415 ( 4.3A)
HEM  A 401 (-3.9A)
 1.20A 2zifB-5ex8A:
undetectable		 2zifB-5ex8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE

(Chaetomium
thermophilum) 		PF03568
(Peptidase_C50) 		5 PRO A2076
ALA A2137
PRO A2136
LEU A2021
VAL A2163
 None
 1.03A 2zifB-5fbyA:
undetectable		 2zifB-5fbyA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffj ENDONUCLEASE AND
METHYLASE LLAGI

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII) 		6 PRO A1020
PHE A 910
PHE A 904
GLY A 906
THR A 907
VAL A 946
 None
 1.21A 2zifB-5ffjA:
2.0		 2zifB-5ffjA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyg CYTOCHROME P450

(Marinobacter
hydrocarbonoclasticus) 		PF00067
(p450) 		5 ALA A 326
SER A 349
ALA A 428
THR A 316
LEU A 324
 None
None
HEM  A1475 (-3.5A)
HEM  A1475 (-4.5A)
None
 1.21A 2zifB-5fygA:
undetectable		 2zifB-5fygA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL

(Homo sapiens) 		PF00180
(Iso_dh) 		5 ALA B 265
SER B 293
ALA B 288
GLY B 257
VAL B 106
 None
 1.17A 2zifB-5grhB:
undetectable		 2zifB-5grhB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grj AVELUMAB H CHAIN
AVELUMAB L CHAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		5 ALA H  92
ALA L  45
PRO L  46
GLY H 113
LEU H 115
 None
 1.19A 2zifB-5grjH:
undetectable		 2zifB-5grjH:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)

(Helicobacter
pylori) 		PF01555
(N6_N4_Mtase) 		5 ALA A   9
PRO A  31
PHE A 195
GLY A 197
TYR A 221
 SAM  A 301 (-3.2A)
SAM  A 301 ( 4.0A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.2A)
 0.43A 2zifB-5hfjA:
19.9		 2zifB-5hfjA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Pseudomonas
aeruginosa) 		PF00202
(Aminotran_3) 		5 PRO A 272
GLY A 308
THR A 311
LEU A 303
VAL A  75
 None
 1.18A 2zifB-5i92A:
undetectable		 2zifB-5i92A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1u NAD(P)H:FLAVIN
OXIDOREDUCTASE SYE4

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		5 ALA A 131
ALA A  73
PHE A 121
GLY A 113
THR A 112
 None
 1.10A 2zifB-5k1uA:
2.7		 2zifB-5k1uA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1t PENTALENOLACTONE
SYNTHASE

(Streptomyces
arenae) 		PF00067
(p450) 		5 PHE A 391
GLY A 244
THR A 245
LEU A 273
VAL A 269
 None
 1.20A 2zifB-5l1tA:
undetectable		 2zifB-5l1tA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens) 		no annotation 5 ALA C 147
SER C 131
ALA C  86
GLY C 384
THR C  89
 None
None
None
SCY  C  88 ( 3.5A)
SCY  C  88 ( 3.8A)
 1.21A 2zifB-5mg5C:
undetectable		 2zifB-5mg5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5min QUINOPROTEIN GLUCOSE
DEHYDROGENASE B

(Acinetobacter
calcoaceticus) 		no annotation 5 SER A 244
ALA A 350
PRO A 351
THR A 348
TYR A 325
 None
CA  A 503 ( 3.9A)
None
None
None
 1.06A 2zifB-5minA:
undetectable		 2zifB-5minA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1

(synthetic
construct) 		no annotation 5 ALA A  90
PRO A 108
GLY A  82
THR A  11
LEU A  88
 None
None
None
GOL  A 300 (-2.9A)
None
 0.98A 2zifB-5tdxA:
2.0		 2zifB-5tdxA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txe ATXE2

(Asticcacaulis
excentricus) 		PF00326
(Peptidase_S9) 		5 ALA A  54
SER A 440
PHE A 416
GLY A 349
THR A 348
 None
 1.13A 2zifB-5txeA:
2.1		 2zifB-5txeA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5van BETA-KLOTHO

(Homo sapiens) 		no annotation 5 ALA A 399
PHE A 374
GLY A 301
VAL A 326
TYR A 243
 None
 1.09A 2zifB-5vanA:
undetectable		 2zifB-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Acinetobacter
baumannii) 		PF00464
(SHMT) 		5 SER A 178
ALA A 294
GLY A 364
THR A 365
VAL A 343
 None
 0.92A 2zifB-5vmbA:
undetectable		 2zifB-5vmbA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF00374
(NiFeSe_Hases) 		5 ALA D 178
SER D  86
PRO D  84
PRO D 395
GLY D 118
 None
None
None
FCO  D 501 ( 3.8A)
None
 1.03A 2zifB-5xfaD:
undetectable		 2zifB-5xfaD:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yu1 LYSINE
CYCLODEAMINASE

(Streptomyces
pristinaespiralis) 		no annotation 5 ALA A 311
SER A 126
PHE A 299
GLY A 303
THR A 302
 None
None
None
NAD  A 402 ( 3.2A)
None
 1.17A 2zifB-5yu1A:
undetectable		 2zifB-5yu1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e0s -

(-) 		no annotation 5 ALA A 113
SER A 101
ALA A  67
GLY A  61
LEU A  88
 None
 1.10A 2zifB-6e0sA:
undetectable		 2zifB-6e0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f74 ALCOHOL OXIDASE

(Thermothelomyces
thermophila) 		no annotation 5 SER A 423
PRO A 232
ALA A 249
PRO A 248
VAL A 215
 None
 1.21A 2zifB-6f74A:
undetectable		 2zifB-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Cyanidioschyzon
merolae) 		no annotation 5 SER B 664
GLY B 658
THR B 657
LEU B 708
VAL B 709
 CLA  B1023 (-4.5A)
None
CLA  B1239 ( 4.4A)
None
CLA  B1226 (-4.4A)
 1.12A 2zifB-6fosB:
undetectable		 2zifB-6fosB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a7j PHOSPHORIBULOKINASE

(Rhodobacter
sphaeroides) 		PF00485
(PRK) 		3 ASP A 169
THR A  11
GLU A 161
 None
 0.76A 2zifB-1a7jA:
undetectable		 2zifB-1a7jA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris) 		PF01555
(N6_N4_Mtase) 		3 ASP A  34
THR A 278
GLU A 294
 SAH  A 401 (-4.0A)
SAH  A 401 (-4.0A)
SAH  A 401 (-2.9A)
 0.25A 2zifB-1booA:
22.2		 2zifB-1booA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3n AGGLUTININ

(Helianthus
tuberosus) 		PF01419
(Jacalin) 		3 ASP A  66
THR A  99
GLU A  69
 None
 0.72A 2zifB-1c3nA:
undetectable		 2zifB-1c3nA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ct9 ASPARAGINE
SYNTHETASE B

(Escherichia
coli) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		3 ASP A 462
THR A 490
GLU A 493
 None
 0.75A 2zifB-1ct9A:
1.4		 2zifB-1ct9A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dr9 T LYMPHOCYTE
ACTIVATION ANTIGEN

(Homo sapiens) 		PF07686
(V-set)
PF08205
(C2-set_2) 		3 ASP A 107
THR A  13
GLU A  10
 None
 0.83A 2zifB-1dr9A:
undetectable		 2zifB-1dr9A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5t DIPHTHERIA TOXIN
REPRESSOR

(Corynebacterium
diphtheriae) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C) 		3 ASP A1099
THR A1008
GLU A1105
 None
None
NI  A 251 (-2.6A)
 0.82A 2zifB-1f5tA:
undetectable		 2zifB-1f5tA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbv SIGNAL TRANSDUCTION
PROTEIN CBL

(Homo sapiens) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3)
PF14447
(Prok-RING_4) 		3 ASP A 390
THR A  50
GLU A 120
 None
 0.77A 2zifB-1fbvA:
undetectable		 2zifB-1fbvA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gmz PHOSPHOLIPASE A2

(Bothrops
pirajai) 		PF00068
(Phospholip_A2_1) 		3 ASP A 101
THR A  72
GLU A  98
 None
 0.70A 2zifB-1gmzA:
undetectable		 2zifB-1gmzA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h74 HOMOSERINE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 ASP A  42
THR A  57
GLU A  45
 None
 0.82A 2zifB-1h74A:
undetectable		 2zifB-1h74A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyn BAND 3 ANION
TRANSPORT PROTEIN

(Homo sapiens) 		PF07565
(Band_3_cyto) 		3 ASP P 277
THR P 179
GLU P 272
 None
 0.70A 2zifB-1hynP:
undetectable		 2zifB-1hynP:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibv HISTIDINE
DECARBOXYLASE ALPHA
CHAIN

(Lactobacillus
sp. 30A) 		PF02329
(HDC) 		3 ASP B 279
THR B 289
GLU B 286
 None
 0.66A 2zifB-1ibvB:
undetectable		 2zifB-1ibvB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		3 ASP A 582
THR A 506
GLU A 500
 CL  A2004 (-4.9A)
None
None
 0.83A 2zifB-1itkA:
undetectable		 2zifB-1itkA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7h ALKALINE PHOSPHATASE

(Pandalus
borealis) 		PF00245
(Alk_phosphatase) 		3 ASP A 251
THR A 271
GLU A 216
 None
SO4  A 483 ( 4.5A)
None
 0.76A 2zifB-1k7hA:
undetectable		 2zifB-1k7hA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8m E2 COMPONENT OF
BRANCHED-CHAIN
ALPHA-KETOACID
DEHYDROGENASE

(Homo sapiens) 		PF00364
(Biotin_lipoyl) 		3 ASP A  36
THR A  20
GLU A  40
 None
 0.63A 2zifB-1k8mA:
undetectable		 2zifB-1k8mA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lln ANTIVIRAL PROTEIN 3

(Phytolacca
americana) 		PF00161
(RIP) 		3 ASP A 249
THR A  10
GLU A 180
 None
None
MLY  A 177 ( 3.3A)
 0.68A 2zifB-1llnA:
undetectable		 2zifB-1llnA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llp LIGNIN PEROXIDASE

(Phanerochaete
chrysosporium) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		3 ASP A 238
THR A 333
GLU A 207
 None
 0.83A 2zifB-1llpA:
undetectable		 2zifB-1llpA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		3 ASP A 178
THR A 325
GLU A 174
 None
 0.74A 2zifB-1lnsA:
1.9		 2zifB-1lnsA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		3 ASP A 259
THR A 266
GLU A 167
 None
 0.76A 2zifB-1lnsA:
1.9		 2zifB-1lnsA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN

(Archaeoglobus
fulgidus) 		PF01269
(Fibrillarin) 		3 ASP A 113
THR A  71
GLU A  88
 SAM  A 301 (-3.6A)
SAM  A 301 (-4.1A)
SAM  A 301 (-2.4A)
 0.77A 2zifB-1nt2A:
4.1		 2zifB-1nt2A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		3 ASP A 602
THR A 556
GLU A 563
 None
 0.80A 2zifB-1ofeA:
undetectable		 2zifB-1ofeA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		3 ASP A 294
THR A 196
GLU A 202
 None
 0.79A 2zifB-1q8yA:
undetectable		 2zifB-1q8yA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu7 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN I

(Escherichia
coli) 		PF00015
(MCPsignal) 		3 ASP A 464
THR A 450
GLU A 458
 None
 0.71A 2zifB-1qu7A:
undetectable		 2zifB-1qu7A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc9 CYSTEINE-RICH
SECRETORY PROTEIN

(Trimeresurus
stejnegeri) 		PF00188
(CAP)
PF08562
(Crisp) 		3 ASP A  47
THR A 184
GLU A  69
 None
 0.68A 2zifB-1rc9A:
undetectable		 2zifB-1rc9A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t34 ATRIAL NATRIURETIC
PEPTIDE RECEPTOR A

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		3 ASP A  39
THR A 349
GLU A 334
 None
 0.84A 2zifB-1t34A:
undetectable		 2zifB-1t34A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ASP A 461
THR A 380
GLU A 386
 None
 0.75A 2zifB-1u59A:
undetectable		 2zifB-1u59A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uw4 UPF3X
REGULATOR OF
NONSENSE TRANSCRIPTS
2

(Homo sapiens;
Homo sapiens) 		PF03467
(Smg4_UPF3)
PF02854
(MIF4G) 		3 ASP B 840
THR A  63
GLU A  81
 None
 0.73A 2zifB-1uw4B:
undetectable		 2zifB-1uw4B:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux1 CYTIDINE DEAMINASE

(Bacillus
subtilis) 		PF00383
(dCMP_cyt_deam_1) 		3 ASP A 100
THR A 106
GLU A 114
 None
 0.75A 2zifB-1ux1A:
undetectable		 2zifB-1ux1A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME

(Campylobacter
jejuni) 		PF01128
(IspD)
PF02542
(YgbB) 		3 ASP A  31
THR A 212
GLU A 209
 None
 0.72A 2zifB-1w55A:
undetectable		 2zifB-1w55A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wj3 KIAA1496 PROTEIN

(Homo sapiens) 		PF00041
(fn3) 		3 ASP A  31
THR A  73
GLU A  76
 None
 0.73A 2zifB-1wj3A:
undetectable		 2zifB-1wj3A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wls L-ASPARAGINASE

(Pyrococcus
horikoshii) 		PF00710
(Asparaginase) 		3 ASP A  84
THR A 261
GLU A 293
 None
 0.63A 2zifB-1wlsA:
undetectable		 2zifB-1wlsA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9n DNA LIGASE I

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		3 ASP A 730
THR A 506
GLU A 734
 None
 0.73A 2zifB-1x9nA:
undetectable		 2zifB-1x9nA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7u HYPOTHETICAL PROTEIN
EF0647

(Enterococcus
faecalis) 		PF01638
(HxlR) 		3 ASP A  43
THR A  32
GLU A  27
 None
 0.76A 2zifB-1z7uA:
undetectable		 2zifB-1z7uA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbx ORIGIN RECOGNITION
COMPLEX SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF01426
(BAH) 		3 ASP A 154
THR A 126
GLU A 131
 None
 0.59A 2zifB-1zbxA:
undetectable		 2zifB-1zbxA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvu TOPOISOMERASE IV
SUBUNIT A

(Escherichia
coli) 		PF00521
(DNA_topoisoIV)
PF03989
(DNA_gyraseA_C) 		3 ASP A 591
THR A 501
GLU A 588
 None
 0.83A 2zifB-1zvuA:
undetectable		 2zifB-1zvuA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkl PROLYL ENDOPEPTIDASE

(Myxococcus
xanthus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 ASP A 118
THR A  87
GLU A  92
 None
 0.81A 2zifB-2bklA:
undetectable		 2zifB-2bklA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bw3 TRANSPOSASE
TRANSPOSASE

(Musca
domestica;
Musca domestica) 		PF05699
(Dimer_Tnp_hAT)
PF10683
(DBD_Tnp_Hermes)
PF10683
(DBD_Tnp_Hermes) 		3 ASP B 133
THR B  85
GLU A 130
 None
 0.83A 2zifB-2bw3B:
undetectable		 2zifB-2bw3B:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Prosthecochloris
vibrioformis) 		PF00490
(ALAD) 		3 ASP A  75
THR A  62
GLU A  69
 None
 0.78A 2zifB-2c1hA:
undetectable		 2zifB-2c1hA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like) 		3 ASP A  42
THR A 292
GLU A  37
 MG  A 401 (-2.5A)
None
None
 0.77A 2zifB-2cw6A:
undetectable		 2zifB-2cw6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		3 ASP A 167
THR A  59
GLU A  56
 None
 0.74A 2zifB-2d62A:
2.4		 2zifB-2d62A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec9 TISSUE FACTOR

(Homo sapiens) 		PF01108
(Tissue_fac) 		3 ASP T  54
THR T  17
GLU T  24
 None
 0.78A 2zifB-2ec9T:
undetectable		 2zifB-2ec9T:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase) 		3 ASP A  68
THR A 106
GLU A 114
 None
 0.83A 2zifB-2f2aA:
undetectable		 2zifB-2f2aA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fdb FIBROBLAST GROWTH
FACTOR 8 ISOFORM B

(Homo sapiens) 		PF00167
(FGF) 		3 ASP M  44
THR M  53
GLU M  89
 None
 0.77A 2zifB-2fdbM:
undetectable		 2zifB-2fdbM:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		3 ASP A 189
THR A 250
GLU A 217
 None
 0.80A 2zifB-2fpgA:
undetectable		 2zifB-2fpgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE

(Pseudomonas
aeruginosa) 		PF00682
(HMGL-like) 		3 ASP A  16
THR A 266
GLU A  11
 NA  A3000 (-2.9A)
None
None
 0.76A 2zifB-2ftpA:
undetectable		 2zifB-2ftpA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hal HEPATITIS A PROTEASE
3C

(Hepatovirus A) 		PF00548
(Peptidase_C3) 		3 ASP A  51
THR A 152
GLU A  49
 None
 0.82A 2zifB-2halA:
undetectable		 2zifB-2halA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hoe N-ACETYLGLUCOSAMINE
KINASE

(Thermotoga
maritima) 		PF00480
(ROK) 		3 ASP A  85
THR A 141
GLU A  81
 None
 0.81A 2zifB-2hoeA:
undetectable		 2zifB-2hoeA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0o SER/THR PHOSPHATASE

(Anopheles
gambiae) 		PF00481
(PP2C) 		3 ASP A 500
THR A 525
GLU A 438
 None
 0.80A 2zifB-2i0oA:
undetectable		 2zifB-2i0oA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idv EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4E-1

(Triticum
aestivum) 		PF01652
(IF4E) 		3 ASP A 148
THR A  74
GLU A  43
 None
 0.69A 2zifB-2idvA:
undetectable		 2zifB-2idvA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ie8 PHOSPHOGLYCERATE
KINASE

(Thermus
caldophilus) 		PF00162
(PGK) 		3 ASP A 197
THR A 381
GLU A 378
 None
 0.80A 2zifB-2ie8A:
3.0		 2zifB-2ie8A:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN

(Homo sapiens) 		PF01269
(Fibrillarin) 		3 ASP A 217
THR A 174
GLU A 192
 MTA  A4001 (-3.4A)
None
MTA  A4001 (-2.7A)
 0.68A 2zifB-2ipxA:
3.4		 2zifB-2ipxA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 YDR362CP

(Saccharomyces
cerevisiae) 		no annotation 3 ASP B 460
THR B 451
GLU B 447
 None
 0.77A 2zifB-2j04B:
undetectable		 2zifB-2j04B:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5c 1,8-CINEOLE SYNTHASE

(Salvia
fruticosa) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 ASP A 400
THR A 335
GLU A 330
 None
 0.69A 2zifB-2j5cA:
undetectable		 2zifB-2j5cA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5g ALR4455 PROTEIN

(Nostoc sp. PCC
7120) 		PF00378
(ECH_1) 		3 ASP D  69
THR D  39
GLU D  74
 None
 0.74A 2zifB-2j5gD:
undetectable		 2zifB-2j5gD:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jqv AIG2 PROTEIN-LIKE

(Arabidopsis
thaliana) 		PF06094
(GGACT) 		3 ASP A 113
THR A  90
GLU A  87
 None
 0.64A 2zifB-2jqvA:
undetectable		 2zifB-2jqvA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kd7 PUTATIVE CHITOBIASE

(Bacteroides
thetaiotaomicron) 		PF00754
(F5_F8_type_C) 		3 ASP A 130
THR A  98
GLU A  87
 None
 0.79A 2zifB-2kd7A:
undetectable		 2zifB-2kd7A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l8b PROTEIN TRAI

(Escherichia
coli) 		no annotation 3 ASP A 479
THR A 504
GLU A 485
 None
 0.72A 2zifB-2l8bA:
1.7		 2zifB-2l8bA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okl PEPTIDE DEFORMYLASE
2

(Bacillus cereus) 		PF01327
(Pep_deformylase) 		3 ASP A  30
THR A   3
GLU A  36
 None
 0.65A 2zifB-2oklA:
undetectable		 2zifB-2oklA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF16073
(SAT) 		3 ASP B  51
THR B 128
GLU B 121
 None
 0.81A 2zifB-2pffB:
undetectable		 2zifB-2pffB:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptt CD48 ANTIGEN

(Mus musculus) 		PF07686
(V-set) 		3 ASP A 104
THR A  83
GLU A 101
 None
 0.72A 2zifB-2pttA:
undetectable		 2zifB-2pttA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2puq TISSUE FACTOR

(Homo sapiens) 		PF01108
(Tissue_fac)
PF09294
(Interfer-bind) 		3 ASP T  54
THR T  17
GLU T  24
 None
 0.81A 2zifB-2puqT:
undetectable		 2zifB-2puqT:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnf RECOMBINATION
ENDONUCLEASE VII

(Escherichia
virus T4) 		PF02945
(Endonuclease_7)
PF09124
(Endonuc-dimeris) 		3 ASP A  17
THR A   4
GLU A  11
 None
 0.82A 2zifB-2qnfA:
undetectable		 2zifB-2qnfA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy6 UPF0209 PROTEIN YFCK

(Escherichia
coli) 		PF05430
(Methyltransf_30) 		3 ASP A 198
THR A 126
GLU A 121
 None
 0.68A 2zifB-2qy6A:
2.0		 2zifB-2qy6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vjt ALLOPHYCOCYANIN
ALPHA SUBUNIT

(Gloeobacter
violaceus) 		PF00502
(Phycobilisome) 		3 ASP A 100
THR A 138
GLU A 148
 None
 0.75A 2zifB-2vjtA:
undetectable		 2zifB-2vjtA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vro ALDEHYDE
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00171
(Aldedh) 		3 ASP A 389
THR A 415
GLU A 306
 None
 0.76A 2zifB-2vroA:
undetectable		 2zifB-2vroA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vtx NPM-A PROTEIN

(Xenopus laevis) 		PF03066
(Nucleoplasmin) 		3 ASP A  67
THR A  80
GLU A  64
 None
 0.75A 2zifB-2vtxA:
undetectable		 2zifB-2vtxA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum) 		PF00245
(Alk_phosphatase) 		3 ASP A 304
THR A 187
GLU A 167
 ZN  A1475 ( 2.0A)
None
None
 0.74A 2zifB-2x98A:
undetectable		 2zifB-2x98A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd7 CORE HISTONE
MACRO-H2A.2

(Homo sapiens) 		PF01661
(Macro) 		3 ASP A 339
THR A 325
GLU A 291
 None
 0.76A 2zifB-2xd7A:
undetectable		 2zifB-2xd7A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfx MHC CLASS 1

(Bos taurus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 ASP A 129
THR A 163
GLU A 161
 None
 0.79A 2zifB-2xfxA:
undetectable		 2zifB-2xfxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 ASP A 274
THR A 326
GLU A 329
 None
 0.68A 2zifB-2yd0A:
undetectable		 2zifB-2yd0A:
15.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zie PUTATIVE
MODIFICATION
METHYLASE

(Thermus
thermophilus) 		PF01555
(N6_N4_Mtase) 		3 ASP A  28
THR A 248
GLU A 264
 None
 0.47A 2zifB-2zieA:
38.4		 2zifB-2zieA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5r BENZALACETONE
SYNTHASE

(Rheum palmatum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 ASP A 220
THR A 353
GLU A 231
 None
 0.74A 2zifB-3a5rA:
undetectable		 2zifB-3a5rA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajz ANCESTRAL CONGERIN
CON-ANC

(-) 		PF00337
(Gal-bind_lectin) 		3 ASP A  37
THR A   8
GLU A  34
 None
 0.65A 2zifB-3ajzA:
undetectable		 2zifB-3ajzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbj PUTATIVE
THIOESTERASE II

(Thermobifida
fusca) 		PF13622
(4HBT_3) 		3 ASP A 251
THR A 169
GLU A 172
 None
 0.81A 2zifB-3bbjA:
undetectable		 2zifB-3bbjA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR

(Bacillus
subtilis) 		PF04198
(Sugar-bind) 		3 ASP A 278
THR A 100
GLU A 315
 None
 0.76A 2zifB-3bxhA:
undetectable		 2zifB-3bxhA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		3 ASP A 141
THR A  56
GLU A  62
 None
 0.73A 2zifB-3c0iA:
undetectable		 2zifB-3c0iA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3m RESPONSE REGULATOR
RECEIVER PROTEIN

(Methanoculleus
marisnigri) 		PF00072
(Response_reg) 		3 ASP A  10
THR A  45
GLU A  37
 None
GOL  A 202 (-3.7A)
None
 0.79A 2zifB-3c3mA:
undetectable		 2zifB-3c3mA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfz UPF0100 PROTEIN
MJ1186

(Methanocaldococcus
jannaschii) 		PF13531
(SBP_bac_11) 		3 ASP A 126
THR A 222
GLU A 229
 None
 0.80A 2zifB-3cfzA:
undetectable		 2zifB-3cfzA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cm5 CELL DEATH-RELATED
NUCLEASE 4

(Caenorhabditis
elegans) 		PF00929
(RNase_T) 		3 ASP A 111
THR A 209
GLU A 206
 None
 0.84A 2zifB-3cm5A:
undetectable		 2zifB-3cm5A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		3 ASP A 238
THR A 156
GLU A 160
 None
 0.75A 2zifB-3ctzA:
undetectable		 2zifB-3ctzA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0c DIHYDRODIPICOLINATE
SYNTHASE

(Oceanobacillus
iheyensis) 		PF00701
(DHDPS) 		3 ASP A 242
THR A  12
GLU A 195
 None
 0.76A 2zifB-3d0cA:
undetectable		 2zifB-3d0cA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3a BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01301
(Glyco_hydro_35) 		3 ASP A 326
THR A 543
GLU A 331
 None
 0.83A 2zifB-3d3aA:
undetectable		 2zifB-3d3aA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3y UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF05193
(Peptidase_M16_C) 		3 ASP A 199
THR A 384
GLU A 372
 None
 0.83A 2zifB-3d3yA:
undetectable		 2zifB-3d3yA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsm UNCHARACTERIZED
PROTEIN BACUNI_02894

(Bacteroides
uniformis) 		no annotation 3 ASP A 204
THR A  21
GLU A 243
 None
 0.79A 2zifB-3dsmA:
undetectable		 2zifB-3dsmA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxp PUTATIVE ACYL-COA
DEHYDROGENASE

(Cupriavidus
pinatubonensis) 		PF01636
(APH) 		3 ASP A  96
THR A 141
GLU A 146
 None
ACT  A 360 (-4.3A)
None
 0.77A 2zifB-3dxpA:
undetectable		 2zifB-3dxpA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e96 DIHYDRODIPICOLINATE
SYNTHASE

(Bacillus
clausii) 		PF00701
(DHDPS) 		3 ASP A 244
THR A  14
GLU A 197
 None
 0.73A 2zifB-3e96A:
undetectable		 2zifB-3e96A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehm SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		3 ASP A 156
THR A 219
GLU A 159
 None
 0.83A 2zifB-3ehmA:
undetectable		 2zifB-3ehmA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqz RESPONSE REGULATOR

(Colwellia
psychrerythraea) 		PF00072
(Response_reg) 		3 ASP A  57
THR A  40
GLU A  62
 ASP  A  57 ( 0.5A)
THR  A  40 ( 0.8A)
GLU  A  62 ( 0.6A)
 0.81A 2zifB-3eqzA:
2.5		 2zifB-3eqzA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g25 GLYCEROL KINASE

(Staphylococcus
aureus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ASP A 125
THR A 207
GLU A 201
 None
 0.83A 2zifB-3g25A:
undetectable		 2zifB-3g25A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gjy SPERMIDINE SYNTHASE

(Corynebacterium
glutamicum) 		no annotation 3 ASP A 144
THR A  99
GLU A 117
 None
None
FMT  A 315 (-3.6A)
 0.58A 2zifB-3gjyA:
2.5		 2zifB-3gjyA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ASP A 323
THR A  42
GLU A 407
 None
 0.73A 2zifB-3gyrA:
undetectable		 2zifB-3gyrA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgq HDA1 COMPLEX SUBUNIT
3

(Saccharomyces
cerevisiae) 		PF11496
(HDA2-3) 		3 ASP A 256
THR A 318
GLU A 261
 None
 0.72A 2zifB-3hgqA:
undetectable		 2zifB-3hgqA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hst PROTEIN
RV2228C/MT2287

(Mycobacterium
tuberculosis) 		PF13456
(RVT_3) 		3 ASP B 128
THR B  31
GLU B  35
 None
 0.75A 2zifB-3hstB:
undetectable		 2zifB-3hstB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11

(Schizosaccharomyces
pombe) 		PF13087
(AAA_12)
PF16399
(Aquarius_N) 		3 ASP X1076
THR X1236
GLU X1085
 None
 0.64A 2zifB-3jb9X:
undetectable		 2zifB-3jb9X:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ka7 OXIDOREDUCTASE

(Methanosarcina
mazei) 		PF01593
(Amino_oxidase) 		3 ASP A 240
THR A 215
GLU A  27
 None
 0.81A 2zifB-3ka7A:
undetectable		 2zifB-3ka7A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kar KINESIN-LIKE PROTEIN
KAR3

(Saccharomyces
cerevisiae) 		PF00225
(Kinesin) 		3 ASP A 414
THR A 425
GLU A 435
 None
 0.64A 2zifB-3karA:
undetectable		 2zifB-3karA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjl PROTEIN SUS1
SAGA-ASSOCIATED
FACTOR 11

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF10163
(EnY2)
no annotation 		3 ASP A  40
THR A  56
GLU E  31
 None
 0.66A 2zifB-3kjlA:
undetectable		 2zifB-3kjlA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ASP A 118
THR A 335
GLU A 463
 None
NAG  A 706 (-4.5A)
None
 0.84A 2zifB-3kw7A:
undetectable		 2zifB-3kw7A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l57 MOBILIZATION PROTEIN
TRAI

(Escherichia
coli) 		PF08751
(TrwC) 		3 ASP A 102
THR A  34
GLU A 150
 None
EDO  A 303 (-4.7A)
None
 0.79A 2zifB-3l57A:
undetectable		 2zifB-3l57A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmm UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF04326
(AlbA_2)
PF13749
(HATPase_c_4) 		3 ASP A 328
THR A 283
GLU A 295
 None
 0.65A 2zifB-3lmmA:
undetectable		 2zifB-3lmmA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgz 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00926
(DHBP_synthase) 		3 ASP A  25
THR A  53
GLU A  31
 None
 0.82A 2zifB-3mgzA:
undetectable		 2zifB-3mgzA:
20.47