SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZIF_A_SAMA298

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)


(Proteus
vulgaris)
PF01555
(N6_N4_Mtase)
7 SER A  53
PRO A  55
PHE A 250
PHE A 273
GLY A 275
THR A 278
GLU A 294
SAH  A 401 (-3.4A)
SAH  A 401 (-3.9A)
SAH  A 401 (-3.4A)
SAH  A 401 (-4.6A)
SAH  A 401 (-3.5A)
SAH  A 401 (-4.0A)
SAH  A 401 (-2.9A)
0.56A 2zifA-1booA:
21.9
2zifA-1booA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)


(Hepacivirus C)
PF00998
(RdRP_3)
5 ALA A  45
PRO A 265
THR A 267
THR A 136
LEU A  10
None
1.21A 2zifA-1csjA:
undetectable
2zifA-1csjA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1


(Saccharopolyspora
erythraea)
PF00067
(p450)
5 ALA A 286
GLY A 253
THR A 254
LEU A 282
VAL A 278
None
1.17A 2zifA-1jioA:
undetectable
2zifA-1jioA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jtd BETA-LACTAMASE
INHIBITOR PROTEIN II


(Streptomyces
exfoliatus)
PF13540
(RCC1_2)
5 ALA B 110
SER B 266
PRO B 303
GLY B 189
THR B 192
None
None
None
CA  B 502 ( 4.9A)
None
1.05A 2zifA-1jtdB:
undetectable
2zifA-1jtdB:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mco IGG1 MCG INTACT
ANTIBODY (HEAVY
CHAIN)


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
5 PRO H 328
PHE H 389
GLY H 356
LEU H 391
VAL H 354
None
1.15A 2zifA-1mcoH:
undetectable
2zifA-1mcoH:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyq THREONYL-TRNA
SYNTHETASE 1


(Staphylococcus
aureus)
PF00587
(tRNA-synt_2b)
PF02824
(TGS)
PF03129
(HGTP_anticodon)
PF07973
(tRNA_SAD)
5 PHE A 539
PHE A 253
GLY A 270
THR A 272
LEU A 265
None
1.23A 2zifA-1nyqA:
undetectable
2zifA-1nyqA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH


(Homo sapiens)
PF01808
(AICARFT_IMPCHas)
PF02142
(MGS)
5 ALA A 100
PRO A 148
THR A 156
LEU A  17
VAL A  18
None
1.19A 2zifA-1pl0A:
undetectable
2zifA-1pl0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE


(Mus musculus)
PF02898
(NO_synthase)
5 ALA A 183
PRO A 135
PHE A 140
GLY A 355
GLU A 352
None
1.08A 2zifA-1qw5A:
undetectable
2zifA-1qw5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32)
PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ)
5 PRO A 197
GLY A 451
THR A 450
THR A 193
LEU A 270
None
1.03A 2zifA-1t1eA:
undetectable
2zifA-1t1eA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysj PROTEIN YXEP

(Bacillus
subtilis)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 ALA A  57
PHE A 129
GLY A  54
THR A  53
VAL A 142
None
1.22A 2zifA-1ysjA:
undetectable
2zifA-1ysjA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE


(Homo sapiens)
PF00398
(RrnaAD)
5 PRO A 130
GLY A  66
THR A  67
GLU A  85
LEU A  86
SAM  A4000 (-4.1A)
SAM  A4000 (-3.2A)
None
SAM  A4000 (-2.8A)
SAM  A4000 (-3.7A)
0.82A 2zifA-1zq9A:
2.8
2zifA-1zq9A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btj GREEN TO RED
PHOTOCONVERTIBLE
GPF-LIKE PROTEIN
EOSFP


(Lobophyllia
hemprichii)
PF01353
(GFP)
6 SER A  92
PHE A 173
GLY A 155
THR A 154
THR A 176
GLU A 144
None
1.31A 2zifA-2btjA:
undetectable
2zifA-2btjA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE


(Thermus
thermophilus)
PF00202
(Aminotran_3)
5 PRO A 273
GLY A 309
THR A 312
LEU A 304
VAL A  77
None
1.06A 2zifA-2e7uA:
undetectable
2zifA-2e7uA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esr METHYLTRANSFERASE

(Streptococcus
pyogenes)
PF03602
(Cons_hypoth95)
5 ALA A 100
PRO A 118
PHE A  49
GLY A  51
GLU A  71
None
1.11A 2zifA-2esrA:
4.4
2zifA-2esrA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esr METHYLTRANSFERASE

(Streptococcus
pyogenes)
PF03602
(Cons_hypoth95)
5 ALA A 100
PRO A 119
PHE A  49
GLY A  51
GLU A  71
None
0.64A 2zifA-2esrA:
4.4
2zifA-2esrA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpo METHYLASE YHHF

(Escherichia
coli)
PF03602
(Cons_hypoth95)
5 ALA A 110
PRO A 129
PHE A  60
GLY A  62
GLU A  82
CL  A 401 (-3.8A)
None
None
None
None
0.72A 2zifA-2fpoA:
2.8
2zifA-2fpoA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR


(Saccharomyces
cerevisiae)
PF00515
(TPR_1)
PF13181
(TPR_8)
PF13432
(TPR_16)
5 ALA A 464
SER A 259
GLY A 504
GLU A 495
LEU A 498
None
1.10A 2zifA-2gw1A:
undetectable
2zifA-2gw1A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw3 KAEDE

(Trachyphyllia
geoffroyi)
PF01353
(GFP)
6 SER A  92
PHE A 173
GLY A 155
THR A 154
THR A 176
GLU A 144
None
1.34A 2zifA-2gw3A:
undetectable
2zifA-2gw3A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0a TRANSCRIPTIONAL
REGULATOR


(Thermus
thermophilus)
PF13377
(Peripla_BP_3)
5 ALA A 169
PRO A 326
GLY A 281
LEU A 328
VAL A 329
None
1.23A 2zifA-2h0aA:
3.4
2zifA-2h0aA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jms PHEROMONE EN-6

(Euplotes
nobilii)
no annotation 5 ALA A  21
PRO A   9
PHE A   7
GLY A  47
THR A  46
None
1.18A 2zifA-2jmsA:
undetectable
2zifA-2jmsA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mjp PYROPHOSPHATASE

(Methanocaldococcus
jannaschii)
PF01725
(Ham1p_like)
5 ALA A 113
PHE A  76
GLY A  86
THR A  87
LEU A  81
None
1.21A 2zifA-2mjpA:
undetectable
2zifA-2mjpA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nbg TRANSLATION
INITIATION FACTOR
IF-2


(Geobacillus
stearothermophilus)
no annotation 5 ALA A 441
PHE A 494
GLY A 453
THR A 454
THR A 455
None
1.13A 2zifA-2nbgA:
undetectable
2zifA-2nbgA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ofk 3-METHYLADENINE DNA
GLYCOSYLASE I,
CONSTITUTIVE


(Salmonella
enterica)
PF03352
(Adenine_glyco)
5 ALA A  94
PHE A 156
GLY A 158
THR A 159
THR A 160
None
0.92A 2zifA-2ofkA:
undetectable
2zifA-2ofkA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qen WALKER-TYPE ATPASE

(Pyrococcus
abyssi)
PF01637
(ATPase_2)
5 ALA A  50
PRO A 202
PHE A 203
GLY A  43
LEU A  48
None
None
None
ADP  A 999 (-3.3A)
None
0.89A 2zifA-2qenA:
3.8
2zifA-2qenA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5g CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 2


(Homo sapiens)
PF13409
(GST_N_2)
PF13410
(GST_C_2)
5 ALA A 219
SER A 185
PHE A 110
LEU A 216
VAL A 212
None
1.23A 2zifA-2r5gA:
undetectable
2zifA-2r5gA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rg2 CHOLOYLGLYCINE
HYDROLASE


(Clostridium
perfringens)
PF02275
(CBAH)
5 PHE A 229
GLY A   4
THR A   3
THR A 174
LEU A  15
None
None
CSO  A   2 ( 3.8A)
CSO  A   2 ( 4.3A)
None
1.24A 2zifA-2rg2A:
undetectable
2zifA-2rg2A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2toh TYROSINE
3-MONOOXYGENASE


(Rattus
norvegicus)
PF00351
(Biopterin_H)
5 ALA A 418
PHE A 345
PHE A 413
GLY A 378
VAL A 410
None
1.16A 2zifA-2tohA:
undetectable
2zifA-2tohA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyo HYPOTHETICAL PROTEIN
ML2640


(Mycobacterium
leprae)
PF04072
(LCM)
5 ALA A 278
PRO A 220
GLY A 187
THR A  17
VAL A 216
None
1.23A 2zifA-2uyoA:
2.3
2zifA-2uyoA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvq RIBOSE-5-PHOSPHATE
ISOMERASE B


(Mycobacterium
tuberculosis)
PF02502
(LacAB_rpiB)
5 ALA A  13
GLY A  74
GLU A  75
LEU A  68
VAL A  67
R10  A 200 ( 3.8A)
R10  A 200 (-3.1A)
R10  A 200 (-2.7A)
None
None
1.18A 2zifA-2vvqA:
undetectable
2zifA-2vvqA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpw ORF14

(Streptomyces
clavuligerus)
PF00583
(Acetyltransf_1)
5 ALA A 247
GLY A 239
THR A 238
THR A 184
VAL A 271
None
1.04A 2zifA-2wpwA:
undetectable
2zifA-2wpwA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN


(Escherichia
coli)
PF02384
(N6_Mtase)
PF12161
(HsdM_N)
6 PHE B 181
GLY B 177
THR B 178
GLU B 216
LEU B 217
VAL B 218
None
1.15A 2zifA-2y7cB:
3.1
2zifA-2y7cB:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN


(Escherichia
coli)
PF02384
(N6_Mtase)
PF12161
(HsdM_N)
6 PRO B 268
PHE B 181
GLY B 177
GLU B 216
LEU B 217
VAL B 218
None
1.29A 2zifA-2y7cB:
3.1
2zifA-2y7cB:
22.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zie PUTATIVE
MODIFICATION
METHYLASE


(Thermus
thermophilus)
PF01555
(N6_N4_Mtase)
10 ALA A  29
PRO A  49
PRO A 219
PHE A 220
GLY A 245
THR A 246
THR A 248
GLU A 264
LEU A 265
VAL A 266
None
0.72A 2zifA-2zieA:
39.6
2zifA-2zieA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zie PUTATIVE
MODIFICATION
METHYLASE


(Thermus
thermophilus)
PF01555
(N6_N4_Mtase)
11 ALA A  29
SER A  47
PRO A  49
PHE A 220
PHE A 243
GLY A 245
THR A 246
THR A 248
GLU A 264
LEU A 265
VAL A 266
None
0.44A 2zifA-2zieA:
39.6
2zifA-2zieA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zie PUTATIVE
MODIFICATION
METHYLASE


(Thermus
thermophilus)
PF01555
(N6_N4_Mtase)
8 SER A  47
PRO A  49
PHE A 220
GLY A 245
THR A 249
GLU A 264
LEU A 265
VAL A 266
None
1.39A 2zifA-2zieA:
39.6
2zifA-2zieA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like)
5 SER A 419
PRO A 421
PRO A 431
PHE A 432
PHE A 460
None
0.88A 2zifA-3abzA:
undetectable
2zifA-3abzA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akf PUTATIVE SECRETED
ALPHA
L-ARABINOFURANOSIDAS
E II


(Streptomyces
avermitilis)
PF04616
(Glyco_hydro_43)
PF05270
(AbfB)
5 ALA A 213
SER A 243
PRO A 245
THR A 240
LEU A 222
None
1.03A 2zifA-3akfA:
undetectable
2zifA-3akfA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxo N,N-DIMETHYLTRANSFER
ASE


(Streptomyces
venezuelae)
PF13649
(Methyltransf_25)
5 GLY A  48
THR A  49
THR A  51
GLU A  67
LEU A  68
SAM  A 238 ( 3.7A)
None
None
SAM  A 238 (-2.7A)
SAM  A 238 (-3.9A)
0.67A 2zifA-3bxoA:
4.8
2zifA-3bxoA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5z TCR B3K506 ALPHA
CHAIN


(Mus musculus)
PF07686
(V-set)
PF09291
(DUF1968)
5 SER A  71
PHE A  72
THR A   4
THR A   6
VAL A 100
None
1.20A 2zifA-3c5zA:
undetectable
2zifA-3c5zA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE


(Thermotoga
maritima)
PF01063
(Aminotran_4)
5 SER A 242
PHE A 243
GLY A 112
THR A 111
VAL A 233
None
1.15A 2zifA-3cswA:
undetectable
2zifA-3cswA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE


(Homo sapiens)
PF02898
(NO_synthase)
5 ALA A 189
PRO A 141
PHE A 146
GLY A 361
GLU A 358
None
1.08A 2zifA-3e7gA:
undetectable
2zifA-3e7gA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edy TRIPEPTIDYL-PEPTIDAS
E 1


(Homo sapiens)
PF09286
(Pro-kuma_activ)
5 ALA A 425
SER A 538
PRO A 544
GLY A 549
THR A 550
None
1.09A 2zifA-3edyA:
undetectable
2zifA-3edyA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B


(Homo sapiens)
PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
5 ALA A 885
PRO A 677
GLY A 805
THR A 804
VAL A 808
None
1.18A 2zifA-3eh1A:
undetectable
2zifA-3eh1A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flo DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A


(Saccharomyces
cerevisiae)
PF08996
(zf-DNA_Pol)
5 SER B1328
PRO B1323
GLY B1441
THR B1440
LEU B1395
None
0.90A 2zifA-3floB:
undetectable
2zifA-3floB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg2 SUGAR DEHYDROGENASE,
UDP-GLUCOSE/GDP-MANN
OSE DEHYDROGENASE
FAMILY


(Porphyromonas
gingivalis)
PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N)
5 PRO A 415
PHE A 466
GLY A 494
THR A 469
LEU A 509
None
1.22A 2zifA-3gg2A:
undetectable
2zifA-3gg2A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jc5 DNA REPLICATION
COMPLEX GINS PROTEIN
PSF3


(Saccharomyces
cerevisiae)
PF05916
(Sld5)
5 ALA C 108
SER C  81
PRO C  77
PHE C  80
GLU C 117
None
1.17A 2zifA-3jc5C:
undetectable
2zifA-3jc5C:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldu PUTATIVE METHYLASE

(Clostridioides
difficile)
PF01170
(UPF0020)
PF02926
(THUMP)
5 ALA A 290
PRO A 307
PRO A 175
GLY A 202
THR A 205
GTP  A 383 (-3.7A)
GTP  A 383 (-3.7A)
GTP  A 383 (-4.3A)
GTP  A 383 (-2.6A)
GTP  A 383 (-3.5A)
0.58A 2zifA-3lduA:
undetectable
2zifA-3lduA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens)
PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N)
5 SER A 561
GLY A 243
THR A 229
GLU A 210
LEU A 569
None
1.12A 2zifA-3lppA:
undetectable
2zifA-3lppA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgk INTRACELLULAR
PROTEASE/AMIDASE
RELATED ENZYME (THIJ
FAMILY)


(Clostridium
acetobutylicum)
PF01965
(DJ-1_PfpI)
5 SER A 109
GLY A 104
THR A 103
THR A 121
LEU A   8
None
1.05A 2zifA-3mgkA:
undetectable
2zifA-3mgkA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2x UNCHARACTERIZED
PROTEIN YAGE


(Escherichia
coli)
PF00701
(DHDPS)
5 SER A  22
PHE A  53
GLY A  55
LEU A  86
VAL A 113
None
None
MCL  A 174 ( 3.2A)
None
None
1.21A 2zifA-3n2xA:
undetectable
2zifA-3n2xA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgh RNA-DIRECTED RNA
POLYMERASE


(Hepacivirus C)
PF00998
(RdRP_3)
5 ALA A  45
PRO A 265
THR A 267
THR A 136
LEU A  10
None
1.22A 2zifA-3qghA:
undetectable
2zifA-3qghA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3quv TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE


(Mycobacteroides
abscessus)
PF01746
(tRNA_m1G_MT)
5 ALA A 143
PRO A  83
PRO A  89
GLY A 134
VAL A 137
None
1.10A 2zifA-3quvA:
undetectable
2zifA-3quvA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ram HMRA PROTEIN

(Staphylococcus
aureus)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 PRO A 126
GLY A  99
THR A 100
LEU A 123
VAL A 122
None
1.20A 2zifA-3ramA:
undetectable
2zifA-3ramA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT


(uncultured
archaeon;
uncultured
archaeon)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
5 ALA B 319
PRO B 368
PHE A 463
GLY B 325
VAL B 310
None
1.19A 2zifA-3sqgB:
undetectable
2zifA-3sqgB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm5 CRYSTAL STRUCTURE OF
TRM14


(Pyrococcus
furiosus)
PF01170
(UPF0020)
PF02926
(THUMP)
5 ALA A 277
PRO A 295
GLY A 227
THR A 230
GLU A 248
SFG  A 401 (-3.1A)
SFG  A 401 ( 4.4A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-3.3A)
SFG  A 401 (-2.6A)
0.56A 2zifA-3tm5A:
3.2
2zifA-3tm5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tma METHYLTRANSFERASE

(Thermus
thermophilus)
PF01170
(UPF0020)
PF02926
(THUMP)
6 ALA A 244
PRO A 262
PHE A 192
GLY A 194
THR A 197
LEU A 217
None
0.75A 2zifA-3tmaA:
4.0
2zifA-3tmaA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulk KETOL-ACID
REDUCTOISOMERASE


(Escherichia
coli)
PF01450
(IlvC)
PF07991
(IlvN)
5 ALA A 488
PRO A 154
PHE A 169
GLY A 199
THR A 198
ALA  A 488 ( 0.0A)
PRO  A 154 (-1.1A)
PHE  A 169 ( 1.3A)
GLY  A 199 ( 0.0A)
THR  A 198 ( 0.8A)
1.04A 2zifA-3ulkA:
undetectable
2zifA-3ulkA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0w WN1 222-5 FAB
(IGG2A) HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 ALA H  23
GLY H 106
THR H  89
GLU H   6
LEU H   4
None
1.22A 2zifA-3v0wH:
undetectable
2zifA-3v0wH:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0w WN1 222-5 FAB
(IGG2A) HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 ALA H  23
GLY H 106
THR H  89
LEU H   4
VAL H  93
None
1.21A 2zifA-3v0wH:
undetectable
2zifA-3v0wH:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v76 FLAVOPROTEIN

(Sinorhizobium
meliloti)
PF03486
(HI0933_like)
5 ALA A 406
PRO A 167
GLY A 163
THR A 172
GLU A 368
FDA  A 547 ( 3.7A)
None
None
FDA  A 547 (-3.1A)
FDA  A 547 (-4.1A)
1.20A 2zifA-3v76A:
undetectable
2zifA-3v76A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x17 ENDOGLUCANASE

(uncultured
bacterium)
no annotation 5 PRO B 397
PHE B 403
GLY B 401
LEU B 408
VAL B 367
None
1.24A 2zifA-3x17B:
undetectable
2zifA-3x17B:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnk L-AMINO ACID OXIDASE

(Streptococcus
cristatus)
PF03486
(HI0933_like)
5 ALA A 192
PRO A 196
GLY A 325
THR A 324
VAL A 246
None
1.16A 2zifA-4cnkA:
undetectable
2zifA-4cnkA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnk L-AMINO ACID OXIDASE

(Streptococcus
cristatus)
PF03486
(HI0933_like)
5 ALA A 378
PRO A 168
GLY A 164
THR A 173
GLU A 362
FAD  A1392 ( 3.7A)
None
None
None
FAD  A1392 (-3.5A)
1.10A 2zifA-4cnkA:
undetectable
2zifA-4cnkA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw4 BETA-KETOACYL
SYNTHASE


(Pseudomonas
aeruginosa)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 SER A 276
PRO A 259
PHE A 220
GLY A 306
VAL A 366
None
1.15A 2zifA-4cw4A:
undetectable
2zifA-4cw4A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffw FAB HEAVY CHAIN

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 SER D  21
GLY D 108
THR D 109
THR D 111
VAL D 106
None
1.18A 2zifA-4ffwD:
undetectable
2zifA-4ffwD:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyl ENOYL-COA HYDRATASE

(Thermoplasma
volcanium)
PF00378
(ECH_1)
5 ALA A  61
SER A 130
PRO A 128
GLY A 140
GLU A 109
CL  A 301 (-3.8A)
None
None
None
None
1.13A 2zifA-4jylA:
undetectable
2zifA-4jylA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kml NANOBODY

(Lama glama)
PF07686
(V-set)
5 ALA B  23
GLY B 117
THR B  93
GLU B   6
LEU B   4
None
1.21A 2zifA-4kmlB:
undetectable
2zifA-4kmlB:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1


(Mycolicibacterium
smegmatis)
PF00082
(Peptidase_S8)
5 ALA A 302
SER A 295
GLY A 238
THR A 240
VAL A 235
None
1.21A 2zifA-4kpgA:
undetectable
2zifA-4kpgA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nec PUTATIVE
SAM-DEPENDENT
METHYLTRANSFERASE


(Streptomyces
lasaliensis)
PF13649
(Methyltransf_25)
5 ALA A  95
SER A 111
GLY A  49
THR A  50
LEU A  69
SAH  A 401 (-3.2A)
SAH  A 401 (-3.3A)
SAH  A 401 (-3.6A)
None
SAH  A 401 (-3.7A)
0.65A 2zifA-4necA:
5.1
2zifA-4necA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE


(Escherichia
coli)
PF00701
(DHDPS)
5 SER A  22
PHE A  53
GLY A  55
LEU A  86
VAL A 113
None
None
PYR  A 410 (-3.2A)
None
None
1.24A 2zifA-4oe7A:
undetectable
2zifA-4oe7A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE


(Gallus gallus;
Rattus
norvegicus;
Lobophyllia
hemprichii)
PF01353
(GFP)
PF13499
(EF-hand_7)
6 SER A 332
PHE A 180
GLY A 162
THR A 161
THR A 183
GLU A 151
GOL  A 504 ( 3.9A)
None
None
None
GOL  A 504 (-2.8A)
None
1.35A 2zifA-4oy4A:
undetectable
2zifA-4oy4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r27 GLYCOSIDE HYDROLASE

(Microbacterium
sp. Gsoil167)
PF00232
(Glyco_hydro_1)
5 ALA A 230
PRO A 173
GLY A 223
THR A 220
LEU A 228
None
1.19A 2zifA-4r27A:
undetectable
2zifA-4r27A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2


(Pisum sativum)
PF00223
(PsaA_PsaB)
5 SER B 666
GLY B 660
THR B 659
LEU B 710
VAL B 711
PQN  B5002 (-3.2A)
None
CLA  B9023 ( 3.7A)
None
CLA  B1239 ( 4.0A)
1.13A 2zifA-4rkuB:
undetectable
2zifA-4rkuB:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A


(Homo sapiens)
PF00145
(DNA_methylase)
5 PRO A 709
PHE A 640
GLY A 642
THR A 645
GLU A 664
SAH  A1004 ( 3.9A)
SAH  A1004 (-4.6A)
SAH  A1004 (-3.3A)
SAH  A1004 (-3.3A)
SAH  A1004 (-3.0A)
0.73A 2zifA-4u7tA:
undetectable
2zifA-4u7tA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoe SPERMIDINE SYNTHASE

(Plasmodium
falciparum)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
5 PRO A 203
PHE A 212
GLY A 124
GLU A 147
VAL A 152
MTA  A 401 (-4.1A)
None
MTA  A 401 (-3.5A)
MTA  A 401 (-2.7A)
MTA  A 401 (-4.3A)
1.18A 2zifA-4uoeA:
2.4
2zifA-4uoeA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis)
PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2)
8 PRO A1020
PHE A 910
PHE A 904
GLY A 906
THR A 907
THR A 909
GLU A 944
VAL A 946
None
1.25A 2zifA-4xqkA:
2.7
2zifA-4xqkA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsz N-METHYLTRANSFERASE

(Streptoalloteichus
sp. ATCC 53650)
PF13649
(Methyltransf_25)
5 ALA A  95
GLY A  55
THR A  56
GLU A  74
LEU A  75
EDO  A 304 (-4.5A)
SAH  A 301 ( 3.7A)
None
SAH  A 301 (-2.9A)
SAH  A 301 (-3.9A)
1.15A 2zifA-5bszA:
3.2
2zifA-5bszA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2c FORM II RUBISCO

(Gallionella)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
5 ALA A 413
PHE A 183
GLY A 395
THR A 163
LEU A 374
None
1.08A 2zifA-5c2cA:
undetectable
2zifA-5c2cA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex8 CYTOCHROME P450

(Streptomyces
toyocaensis)
PF00067
(p450)
5 PHE A 186
PHE A 228
GLY A 224
THR A 223
LEU A  85
None
EDO  A 402 (-4.2A)
EDO  A 415 (-3.7A)
EDO  A 415 ( 4.3A)
HEM  A 401 (-3.9A)
1.24A 2zifA-5ex8A:
undetectable
2zifA-5ex8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffj ENDONUCLEASE AND
METHYLASE LLAGI


(Lactococcus
lactis)
PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
7 PRO A1020
PHE A 904
GLY A 906
THR A 907
THR A 909
GLU A 944
VAL A 946
None
0.64A 2zifA-5ffjA:
2.6
2zifA-5ffjA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffj ENDONUCLEASE AND
METHYLASE LLAGI


(Lactococcus
lactis)
PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
7 PRO A1020
PHE A 910
PHE A 904
GLY A 906
THR A 907
THR A 909
VAL A 946
None
1.26A 2zifA-5ffjA:
2.6
2zifA-5ffjA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj4 SERINE PROTEASE
SUBUNIT NS2B
SERINE PROTEASE NS3


(Zika virus;
Zika virus)
PF01002
(Flavi_NS2B)
PF00949
(Peptidase_S7)
5 ALA B 164
SER A  85
PHE A  84
GLY A 128
THR A 127
None
1.18A 2zifA-5gj4B:
undetectable
2zifA-5gj4B:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl9 BETA-LACTAMASE

(Burkholderia
thailandensis)
PF13354
(Beta-lactamase2)
6 ALA A 283
PRO A  67
PHE A  66
GLY A 244
THR A 243
THR A 266
None
1.35A 2zifA-5gl9A:
undetectable
2zifA-5gl9A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)


(Helicobacter
pylori)
PF01555
(N6_N4_Mtase)
6 ALA A   9
PRO A  31
PHE A 195
GLY A 197
THR A 200
GLU A 216
SAM  A 301 (-3.2A)
SAM  A 301 ( 4.0A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.1A)
0.55A 2zifA-5hfjA:
19.5
2zifA-5hfjA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9r CHOLOYLGLYCINE
HYDROLASE


(Agrobacterium
tumefaciens)
PF02275
(CBAH)
5 SER A 211
PHE A 207
THR A   2
THR A 173
VAL A 259
None
1.21A 2zifA-5j9rA:
undetectable
2zifA-5j9rA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyg ACTIN-LIKE ATPASE

(Magnetospirillum
magneticum)
PF06723
(MreB_Mbl)
5 ALA A 253
SER A 222
GLY A 225
THR A 226
THR A 228
None
ADP  A 402 (-3.5A)
None
None
None
1.15A 2zifA-5jygA:
undetectable
2zifA-5jygA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1t PENTALENOLACTONE
SYNTHASE


(Streptomyces
arenae)
PF00067
(p450)
5 PHE A 391
GLY A 244
THR A 245
LEU A 273
VAL A 269
None
1.12A 2zifA-5l1tA:
undetectable
2zifA-5l1tA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3r SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00448
(SRP54)
PF02881
(SRP54_N)
5 ALA A 334
SER A 167
GLY A 319
THR A 318
VAL A 295
None
1.24A 2zifA-5l3rA:
undetectable
2zifA-5l3rA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE ALPHA
SUBUNIT


(Aromatoleum
aromaticum)
PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N)
5 ALA b 313
SER b 334
GLY b 317
THR b 354
THR b 352
None
None
ADP  b 801 ( 4.0A)
ADP  b 801 (-3.8A)
None
1.24A 2zifA-5l9wb:
undetectable
2zifA-5l9wb:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc8 ARACHIDONATE
15-LIPOXYGENASE


(Pseudomonas
aeruginosa)
PF00305
(Lipoxygenase)
5 ALA A 496
SER A 505
GLY A 536
THR A 535
THR A 510
None
1.18A 2zifA-5lc8A:
undetectable
2zifA-5lc8A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea)
no annotation 5 PRO A 514
GLY A 487
THR A 492
THR A 450
GLU A 489
None
1.13A 2zifA-5n6vA:
undetectable
2zifA-5n6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1


(synthetic
construct)
no annotation 5 ALA A  90
PRO A 108
GLY A  82
THR A  11
LEU A  88
None
None
None
GOL  A 300 (-2.9A)
None
1.02A 2zifA-5tdxA:
undetectable
2zifA-5tdxA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txe ATXE2

(Asticcacaulis
excentricus)
PF00326
(Peptidase_S9)
5 ALA A  54
SER A 440
PHE A 416
GLY A 349
THR A 348
None
1.17A 2zifA-5txeA:
2.3
2zifA-5txeA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029


(Streptococcus
pneumoniae)
no annotation 5 ALA A 361
GLY A 314
THR A 317
GLU A 333
LEU A 334
None
0.76A 2zifA-5xj1A:
2.1
2zifA-5xj1A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtw MACROPHAGE MANNOSE
RECEPTOR 1


(Homo sapiens)
no annotation 5 ALA A 185
PHE A 174
GLY A 195
THR A 196
THR A 197
None
1.21A 2zifA-5xtwA:
undetectable
2zifA-5xtwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yu1 LYSINE
CYCLODEAMINASE


(Streptomyces
pristinaespiralis)
no annotation 5 ALA A 311
SER A 126
PHE A 299
GLY A 303
THR A 302
None
None
None
NAD  A 402 ( 3.2A)
None
1.22A 2zifA-5yu1A:
undetectable
2zifA-5yu1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A


(Homo sapiens)
no annotation 5 PRO A 709
PHE A 640
GLY A 642
THR A 645
GLU A 664
SAH  A1001 (-3.7A)
SAH  A1001 (-4.4A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.5A)
SAH  A1001 (-2.7A)
0.55A 2zifA-6brrA:
4.0
2zifA-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cdm VFP7.04 HEAVY CHAIN

(Mus musculus)
no annotation 5 SER A  21
GLY A 104
THR A 105
THR A 107
VAL A 102
None
1.20A 2zifA-6cdmA:
undetectable
2zifA-6cdmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exs PEPTIDE ABC
TRANSPORTER PERMEASE


(Staphylococcus
hominis)
no annotation 5 ALA A 452
SER A  69
PHE A 257
THR A 263
VAL A 269
None
1.23A 2zifA-6exsA:
undetectable
2zifA-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2


(Cyanidioschyzon
merolae)
no annotation 5 SER B 664
GLY B 658
THR B 657
LEU B 708
VAL B 709
CLA  B1023 (-4.5A)
None
CLA  B1239 ( 4.4A)
None
CLA  B1226 (-4.4A)
1.13A 2zifA-6fosB:
undetectable
2zifA-6fosB:
undetectable