SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZIF_A_SAMA298
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1boo | PROTEIN (N-4CYTOSINE-SPECIFICMETHYLTRANSFERASEPVU II) (Proteusvulgaris) |
PF01555(N6_N4_Mtase) | 7 | SER A 53PRO A 55PHE A 250PHE A 273GLY A 275THR A 278GLU A 294 | SAH A 401 (-3.4A)SAH A 401 (-3.9A)SAH A 401 (-3.4A)SAH A 401 (-4.6A)SAH A 401 (-3.5A)SAH A 401 (-4.0A)SAH A 401 (-2.9A) | 0.56A | 2zifA-1booA:21.9 | 2zifA-1booA:27.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1csj | HEPATITIS C VIRUSRNA POLYMERASE(NS5B) (Hepacivirus C) |
PF00998(RdRP_3) | 5 | ALA A 45PRO A 265THR A 267THR A 136LEU A 10 | None | 1.21A | 2zifA-1csjA:undetectable | 2zifA-1csjA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jio | CYTOCHROME P450107A1 (Saccharopolysporaerythraea) |
PF00067(p450) | 5 | ALA A 286GLY A 253THR A 254LEU A 282VAL A 278 | None | 1.17A | 2zifA-1jioA:undetectable | 2zifA-1jioA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jtd | BETA-LACTAMASEINHIBITOR PROTEIN II (Streptomycesexfoliatus) |
PF13540(RCC1_2) | 5 | ALA B 110SER B 266PRO B 303GLY B 189THR B 192 | NoneNoneNone CA B 502 ( 4.9A)None | 1.05A | 2zifA-1jtdB:undetectable | 2zifA-1jtdB:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mco | IGG1 MCG INTACTANTIBODY (HEAVYCHAIN) (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 5 | PRO H 328PHE H 389GLY H 356LEU H 391VAL H 354 | None | 1.15A | 2zifA-1mcoH:undetectable | 2zifA-1mcoH:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nyq | THREONYL-TRNASYNTHETASE 1 (Staphylococcusaureus) |
PF00587(tRNA-synt_2b)PF02824(TGS)PF03129(HGTP_anticodon)PF07973(tRNA_SAD) | 5 | PHE A 539PHE A 253GLY A 270THR A 272LEU A 265 | None | 1.23A | 2zifA-1nyqA:undetectable | 2zifA-1nyqA:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pl0 | BIFUNCTIONAL PURINEBIOSYNTHESIS PROTEINPURH (Homo sapiens) |
PF01808(AICARFT_IMPCHas)PF02142(MGS) | 5 | ALA A 100PRO A 148THR A 156LEU A 17VAL A 18 | None | 1.19A | 2zifA-1pl0A:undetectable | 2zifA-1pl0A:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qw5 | NITRIC OXIDESYNTHASE, INDUCIBLE (Mus musculus) |
PF02898(NO_synthase) | 5 | ALA A 183PRO A 135PHE A 140GLY A 355GLU A 352 | None | 1.08A | 2zifA-1qw5A:undetectable | 2zifA-1qw5A:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t1e | KUMAMOLISIN (Bacillus sp.MN-32) |
PF00082(Peptidase_S8)PF09286(Pro-kuma_activ) | 5 | PRO A 197GLY A 451THR A 450THR A 193LEU A 270 | None | 1.03A | 2zifA-1t1eA:undetectable | 2zifA-1t1eA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ysj | PROTEIN YXEP (Bacillussubtilis) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | ALA A 57PHE A 129GLY A 54THR A 53VAL A 142 | None | 1.22A | 2zifA-1ysjA:undetectable | 2zifA-1ysjA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zq9 | PROBABLEDIMETHYLADENOSINETRANSFERASE (Homo sapiens) |
PF00398(RrnaAD) | 5 | PRO A 130GLY A 66THR A 67GLU A 85LEU A 86 | SAM A4000 (-4.1A)SAM A4000 (-3.2A)NoneSAM A4000 (-2.8A)SAM A4000 (-3.7A) | 0.82A | 2zifA-1zq9A:2.8 | 2zifA-1zq9A:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2btj | GREEN TO REDPHOTOCONVERTIBLEGPF-LIKE PROTEINEOSFP (Lobophylliahemprichii) |
PF01353(GFP) | 6 | SER A 92PHE A 173GLY A 155THR A 154THR A 176GLU A 144 | None | 1.31A | 2zifA-2btjA:undetectable | 2zifA-2btjA:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e7u | GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE (Thermusthermophilus) |
PF00202(Aminotran_3) | 5 | PRO A 273GLY A 309THR A 312LEU A 304VAL A 77 | None | 1.06A | 2zifA-2e7uA:undetectable | 2zifA-2e7uA:23.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2esr | METHYLTRANSFERASE (Streptococcuspyogenes) |
PF03602(Cons_hypoth95) | 5 | ALA A 100PRO A 118PHE A 49GLY A 51GLU A 71 | None | 1.11A | 2zifA-2esrA:4.4 | 2zifA-2esrA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2esr | METHYLTRANSFERASE (Streptococcuspyogenes) |
PF03602(Cons_hypoth95) | 5 | ALA A 100PRO A 119PHE A 49GLY A 51GLU A 71 | None | 0.64A | 2zifA-2esrA:4.4 | 2zifA-2esrA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fpo | METHYLASE YHHF (Escherichiacoli) |
PF03602(Cons_hypoth95) | 5 | ALA A 110PRO A 129PHE A 60GLY A 62GLU A 82 | CL A 401 (-3.8A)NoneNoneNoneNone | 0.72A | 2zifA-2fpoA:2.8 | 2zifA-2fpoA:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gw1 | MITOCHONDRIALPRECURSOR PROTEINSIMPORT RECEPTOR (Saccharomycescerevisiae) |
PF00515(TPR_1)PF13181(TPR_8)PF13432(TPR_16) | 5 | ALA A 464SER A 259GLY A 504GLU A 495LEU A 498 | None | 1.10A | 2zifA-2gw1A:undetectable | 2zifA-2gw1A:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gw3 | KAEDE (Trachyphylliageoffroyi) |
PF01353(GFP) | 6 | SER A 92PHE A 173GLY A 155THR A 154THR A 176GLU A 144 | None | 1.34A | 2zifA-2gw3A:undetectable | 2zifA-2gw3A:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h0a | TRANSCRIPTIONALREGULATOR (Thermusthermophilus) |
PF13377(Peripla_BP_3) | 5 | ALA A 169PRO A 326GLY A 281LEU A 328VAL A 329 | None | 1.23A | 2zifA-2h0aA:3.4 | 2zifA-2h0aA:25.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jms | PHEROMONE EN-6 (Euplotesnobilii) |
no annotation | 5 | ALA A 21PRO A 9PHE A 7GLY A 47THR A 46 | None | 1.18A | 2zifA-2jmsA:undetectable | 2zifA-2jmsA:10.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mjp | PYROPHOSPHATASE (Methanocaldococcusjannaschii) |
PF01725(Ham1p_like) | 5 | ALA A 113PHE A 76GLY A 86THR A 87LEU A 81 | None | 1.21A | 2zifA-2mjpA:undetectable | 2zifA-2mjpA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nbg | TRANSLATIONINITIATION FACTORIF-2 (Geobacillusstearothermophilus) |
no annotation | 5 | ALA A 441PHE A 494GLY A 453THR A 454THR A 455 | None | 1.13A | 2zifA-2nbgA:undetectable | 2zifA-2nbgA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ofk | 3-METHYLADENINE DNAGLYCOSYLASE I,CONSTITUTIVE (Salmonellaenterica) |
PF03352(Adenine_glyco) | 5 | ALA A 94PHE A 156GLY A 158THR A 159THR A 160 | None | 0.92A | 2zifA-2ofkA:undetectable | 2zifA-2ofkA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qen | WALKER-TYPE ATPASE (Pyrococcusabyssi) |
PF01637(ATPase_2) | 5 | ALA A 50PRO A 202PHE A 203GLY A 43LEU A 48 | NoneNoneNoneADP A 999 (-3.3A)None | 0.89A | 2zifA-2qenA:3.8 | 2zifA-2qenA:25.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r5g | CHLORIDEINTRACELLULARCHANNEL PROTEIN 2 (Homo sapiens) |
PF13409(GST_N_2)PF13410(GST_C_2) | 5 | ALA A 219SER A 185PHE A 110LEU A 216VAL A 212 | None | 1.23A | 2zifA-2r5gA:undetectable | 2zifA-2r5gA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rg2 | CHOLOYLGLYCINEHYDROLASE (Clostridiumperfringens) |
PF02275(CBAH) | 5 | PHE A 229GLY A 4THR A 3THR A 174LEU A 15 | NoneNoneCSO A 2 ( 3.8A)CSO A 2 ( 4.3A)None | 1.24A | 2zifA-2rg2A:undetectable | 2zifA-2rg2A:17.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2toh | TYROSINE3-MONOOXYGENASE (Rattusnorvegicus) |
PF00351(Biopterin_H) | 5 | ALA A 418PHE A 345PHE A 413GLY A 378VAL A 410 | None | 1.16A | 2zifA-2tohA:undetectable | 2zifA-2tohA:23.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uyo | HYPOTHETICAL PROTEINML2640 (Mycobacteriumleprae) |
PF04072(LCM) | 5 | ALA A 278PRO A 220GLY A 187THR A 17VAL A 216 | None | 1.23A | 2zifA-2uyoA:2.3 | 2zifA-2uyoA:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vvq | RIBOSE-5-PHOSPHATEISOMERASE B (Mycobacteriumtuberculosis) |
PF02502(LacAB_rpiB) | 5 | ALA A 13GLY A 74GLU A 75LEU A 68VAL A 67 | R10 A 200 ( 3.8A)R10 A 200 (-3.1A)R10 A 200 (-2.7A)NoneNone | 1.18A | 2zifA-2vvqA:undetectable | 2zifA-2vvqA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wpw | ORF14 (Streptomycesclavuligerus) |
PF00583(Acetyltransf_1) | 5 | ALA A 247GLY A 239THR A 238THR A 184VAL A 271 | None | 1.04A | 2zifA-2wpwA:undetectable | 2zifA-2wpwA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y7c | TYPE I RESTRICTIONENZYME ECOKI MPROTEIN (Escherichiacoli) |
PF02384(N6_Mtase)PF12161(HsdM_N) | 6 | PHE B 181GLY B 177THR B 178GLU B 216LEU B 217VAL B 218 | None | 1.15A | 2zifA-2y7cB:3.1 | 2zifA-2y7cB:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y7c | TYPE I RESTRICTIONENZYME ECOKI MPROTEIN (Escherichiacoli) |
PF02384(N6_Mtase)PF12161(HsdM_N) | 6 | PRO B 268PHE B 181GLY B 177GLU B 216LEU B 217VAL B 218 | None | 1.29A | 2zifA-2y7cB:3.1 | 2zifA-2y7cB:22.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zie | PUTATIVEMODIFICATIONMETHYLASE (Thermusthermophilus) |
PF01555(N6_N4_Mtase) | 10 | ALA A 29PRO A 49PRO A 219PHE A 220GLY A 245THR A 246THR A 248GLU A 264LEU A 265VAL A 266 | None | 0.72A | 2zifA-2zieA:39.6 | 2zifA-2zieA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zie | PUTATIVEMODIFICATIONMETHYLASE (Thermusthermophilus) |
PF01555(N6_N4_Mtase) | 11 | ALA A 29SER A 47PRO A 49PHE A 220PHE A 243GLY A 245THR A 246THR A 248GLU A 264LEU A 265VAL A 266 | None | 0.44A | 2zifA-2zieA:39.6 | 2zifA-2zieA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zie | PUTATIVEMODIFICATIONMETHYLASE (Thermusthermophilus) |
PF01555(N6_N4_Mtase) | 8 | SER A 47PRO A 49PHE A 220GLY A 245THR A 249GLU A 264LEU A 265VAL A 266 | None | 1.39A | 2zifA-2zieA:39.6 | 2zifA-2zieA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3abz | BETA-GLUCOSIDASE I (Kluyveromycesmarxianus) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF07691(PA14)PF14310(Fn3-like) | 5 | SER A 419PRO A 421PRO A 431PHE A 432PHE A 460 | None | 0.88A | 2zifA-3abzA:undetectable | 2zifA-3abzA:16.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3akf | PUTATIVE SECRETEDALPHAL-ARABINOFURANOSIDASE II (Streptomycesavermitilis) |
PF04616(Glyco_hydro_43)PF05270(AbfB) | 5 | ALA A 213SER A 243PRO A 245THR A 240LEU A 222 | None | 1.03A | 2zifA-3akfA:undetectable | 2zifA-3akfA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bxo | N,N-DIMETHYLTRANSFERASE (Streptomycesvenezuelae) |
PF13649(Methyltransf_25) | 5 | GLY A 48THR A 49THR A 51GLU A 67LEU A 68 | SAM A 238 ( 3.7A)NoneNoneSAM A 238 (-2.7A)SAM A 238 (-3.9A) | 0.67A | 2zifA-3bxoA:4.8 | 2zifA-3bxoA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c5z | TCR B3K506 ALPHACHAIN (Mus musculus) |
PF07686(V-set)PF09291(DUF1968) | 5 | SER A 71PHE A 72THR A 4THR A 6VAL A 100 | None | 1.20A | 2zifA-3c5zA:undetectable | 2zifA-3c5zA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3csw | PUTATIVEBRANCHED-CHAIN-AMINO-ACIDAMINOTRANSFERASE (Thermotogamaritima) |
PF01063(Aminotran_4) | 5 | SER A 242PHE A 243GLY A 112THR A 111VAL A 233 | None | 1.15A | 2zifA-3cswA:undetectable | 2zifA-3cswA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e7g | NITRIC OXIDESYNTHASE, INDUCIBLE (Homo sapiens) |
PF02898(NO_synthase) | 5 | ALA A 189PRO A 141PHE A 146GLY A 361GLU A 358 | None | 1.08A | 2zifA-3e7gA:undetectable | 2zifA-3e7gA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3edy | TRIPEPTIDYL-PEPTIDASE 1 (Homo sapiens) |
PF09286(Pro-kuma_activ) | 5 | ALA A 425SER A 538PRO A 544GLY A 549THR A 550 | None | 1.09A | 2zifA-3edyA:undetectable | 2zifA-3edyA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eh1 | PROTEIN TRANSPORTPROTEIN SEC24B (Homo sapiens) |
PF00626(Gelsolin)PF04810(zf-Sec23_Sec24)PF04811(Sec23_trunk)PF04815(Sec23_helical)PF08033(Sec23_BS) | 5 | ALA A 885PRO A 677GLY A 805THR A 804VAL A 808 | None | 1.18A | 2zifA-3eh1A:undetectable | 2zifA-3eh1A:16.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3flo | DNA POLYMERASE ALPHACATALYTIC SUBUNIT A (Saccharomycescerevisiae) |
PF08996(zf-DNA_Pol) | 5 | SER B1328PRO B1323GLY B1441THR B1440LEU B1395 | None | 0.90A | 2zifA-3floB:undetectable | 2zifA-3floB:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gg2 | SUGAR DEHYDROGENASE,UDP-GLUCOSE/GDP-MANNOSE DEHYDROGENASEFAMILY (Porphyromonasgingivalis) |
PF00984(UDPG_MGDP_dh)PF03720(UDPG_MGDP_dh_C)PF03721(UDPG_MGDP_dh_N) | 5 | PRO A 415PHE A 466GLY A 494THR A 469LEU A 509 | None | 1.22A | 2zifA-3gg2A:undetectable | 2zifA-3gg2A:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jc5 | DNA REPLICATIONCOMPLEX GINS PROTEINPSF3 (Saccharomycescerevisiae) |
PF05916(Sld5) | 5 | ALA C 108SER C 81PRO C 77PHE C 80GLU C 117 | None | 1.17A | 2zifA-3jc5C:undetectable | 2zifA-3jc5C:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ldu | PUTATIVE METHYLASE (Clostridioidesdifficile) |
PF01170(UPF0020)PF02926(THUMP) | 5 | ALA A 290PRO A 307PRO A 175GLY A 202THR A 205 | GTP A 383 (-3.7A)GTP A 383 (-3.7A)GTP A 383 (-4.3A)GTP A 383 (-2.6A)GTP A 383 (-3.5A) | 0.58A | 2zifA-3lduA:undetectable | 2zifA-3lduA:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lpp | SUCRASE-ISOMALTASE (Homo sapiens) |
PF00088(Trefoil)PF01055(Glyco_hydro_31)PF16863(NtCtMGAM_N) | 5 | SER A 561GLY A 243THR A 229GLU A 210LEU A 569 | None | 1.12A | 2zifA-3lppA:undetectable | 2zifA-3lppA:15.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mgk | INTRACELLULARPROTEASE/AMIDASERELATED ENZYME (THIJFAMILY) (Clostridiumacetobutylicum) |
PF01965(DJ-1_PfpI) | 5 | SER A 109GLY A 104THR A 103THR A 121LEU A 8 | None | 1.05A | 2zifA-3mgkA:undetectable | 2zifA-3mgkA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n2x | UNCHARACTERIZEDPROTEIN YAGE (Escherichiacoli) |
PF00701(DHDPS) | 5 | SER A 22PHE A 53GLY A 55LEU A 86VAL A 113 | NoneNoneMCL A 174 ( 3.2A)NoneNone | 1.21A | 2zifA-3n2xA:undetectable | 2zifA-3n2xA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qgh | RNA-DIRECTED RNAPOLYMERASE (Hepacivirus C) |
PF00998(RdRP_3) | 5 | ALA A 45PRO A 265THR A 267THR A 136LEU A 10 | None | 1.22A | 2zifA-3qghA:undetectable | 2zifA-3qghA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3quv | TRNA(GUANINE-N(1)-)-METHYLTRANSFERASE (Mycobacteroidesabscessus) |
PF01746(tRNA_m1G_MT) | 5 | ALA A 143PRO A 83PRO A 89GLY A 134VAL A 137 | None | 1.10A | 2zifA-3quvA:undetectable | 2zifA-3quvA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ram | HMRA PROTEIN (Staphylococcusaureus) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | PRO A 126GLY A 99THR A 100LEU A 123VAL A 122 | None | 1.20A | 2zifA-3ramA:undetectable | 2zifA-3ramA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sqg | METHYL COENZYME MREDUCTASE, ALPHASUBUNITMETHYL-COENZYME MREDUCTASE, BETASUBUNIT (unculturedarchaeon;unculturedarchaeon) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N)PF02241(MCR_beta)PF02783(MCR_beta_N) | 5 | ALA B 319PRO B 368PHE A 463GLY B 325VAL B 310 | None | 1.19A | 2zifA-3sqgB:undetectable | 2zifA-3sqgB:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tm5 | CRYSTAL STRUCTURE OFTRM14 (Pyrococcusfuriosus) |
PF01170(UPF0020)PF02926(THUMP) | 5 | ALA A 277PRO A 295GLY A 227THR A 230GLU A 248 | SFG A 401 (-3.1A)SFG A 401 ( 4.4A)SFG A 401 ( 3.7A)SFG A 401 (-3.3A)SFG A 401 (-2.6A) | 0.56A | 2zifA-3tm5A:3.2 | 2zifA-3tm5A:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tma | METHYLTRANSFERASE (Thermusthermophilus) |
PF01170(UPF0020)PF02926(THUMP) | 6 | ALA A 244PRO A 262PHE A 192GLY A 194THR A 197LEU A 217 | None | 0.75A | 2zifA-3tmaA:4.0 | 2zifA-3tmaA:24.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ulk | KETOL-ACIDREDUCTOISOMERASE (Escherichiacoli) |
PF01450(IlvC)PF07991(IlvN) | 5 | ALA A 488PRO A 154PHE A 169GLY A 199THR A 198 | ALA A 488 ( 0.0A)PRO A 154 (-1.1A)PHE A 169 ( 1.3A)GLY A 199 ( 0.0A)THR A 198 ( 0.8A) | 1.04A | 2zifA-3ulkA:undetectable | 2zifA-3ulkA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v0w | WN1 222-5 FAB(IGG2A) HEAVY CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 5 | ALA H 23GLY H 106THR H 89GLU H 6LEU H 4 | None | 1.22A | 2zifA-3v0wH:undetectable | 2zifA-3v0wH:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v0w | WN1 222-5 FAB(IGG2A) HEAVY CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 5 | ALA H 23GLY H 106THR H 89LEU H 4VAL H 93 | None | 1.21A | 2zifA-3v0wH:undetectable | 2zifA-3v0wH:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v76 | FLAVOPROTEIN (Sinorhizobiummeliloti) |
PF03486(HI0933_like) | 5 | ALA A 406PRO A 167GLY A 163THR A 172GLU A 368 | FDA A 547 ( 3.7A)NoneNoneFDA A 547 (-3.1A)FDA A 547 (-4.1A) | 1.20A | 2zifA-3v76A:undetectable | 2zifA-3v76A:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3x17 | ENDOGLUCANASE (unculturedbacterium) |
no annotation | 5 | PRO B 397PHE B 403GLY B 401LEU B 408VAL B 367 | None | 1.24A | 2zifA-3x17B:undetectable | 2zifA-3x17B:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cnk | L-AMINO ACID OXIDASE (Streptococcuscristatus) |
PF03486(HI0933_like) | 5 | ALA A 192PRO A 196GLY A 325THR A 324VAL A 246 | None | 1.16A | 2zifA-4cnkA:undetectable | 2zifA-4cnkA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cnk | L-AMINO ACID OXIDASE (Streptococcuscristatus) |
PF03486(HI0933_like) | 5 | ALA A 378PRO A 168GLY A 164THR A 173GLU A 362 | FAD A1392 ( 3.7A)NoneNoneNoneFAD A1392 (-3.5A) | 1.10A | 2zifA-4cnkA:undetectable | 2zifA-4cnkA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cw4 | BETA-KETOACYLSYNTHASE (Pseudomonasaeruginosa) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | SER A 276PRO A 259PHE A 220GLY A 306VAL A 366 | None | 1.15A | 2zifA-4cw4A:undetectable | 2zifA-4cw4A:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ffw | FAB HEAVY CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 5 | SER D 21GLY D 108THR D 109THR D 111VAL D 106 | None | 1.18A | 2zifA-4ffwD:undetectable | 2zifA-4ffwD:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jyl | ENOYL-COA HYDRATASE (Thermoplasmavolcanium) |
PF00378(ECH_1) | 5 | ALA A 61SER A 130PRO A 128GLY A 140GLU A 109 | CL A 301 (-3.8A)NoneNoneNoneNone | 1.13A | 2zifA-4jylA:undetectable | 2zifA-4jylA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kml | NANOBODY (Lama glama) |
PF07686(V-set) | 5 | ALA B 23GLY B 117THR B 93GLU B 6LEU B 4 | None | 1.21A | 2zifA-4kmlB:undetectable | 2zifA-4kmlB:16.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpg | MEMBRANE-ANCHOREDMYCOSIN MYCP1 (Mycolicibacteriumsmegmatis) |
PF00082(Peptidase_S8) | 5 | ALA A 302SER A 295GLY A 238THR A 240VAL A 235 | None | 1.21A | 2zifA-4kpgA:undetectable | 2zifA-4kpgA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nec | PUTATIVESAM-DEPENDENTMETHYLTRANSFERASE (Streptomyceslasaliensis) |
PF13649(Methyltransf_25) | 5 | ALA A 95SER A 111GLY A 49THR A 50LEU A 69 | SAH A 401 (-3.2A)SAH A 401 (-3.3A)SAH A 401 (-3.6A)NoneSAH A 401 (-3.7A) | 0.65A | 2zifA-4necA:5.1 | 2zifA-4necA:23.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oe7 | PROBABLE2-KETO-3-DEOXY-GALACTONATE ALDOLASE YAGE (Escherichiacoli) |
PF00701(DHDPS) | 5 | SER A 22PHE A 53GLY A 55LEU A 86VAL A 113 | NoneNonePYR A 410 (-3.2A)NoneNone | 1.24A | 2zifA-4oe7A:undetectable | 2zifA-4oe7A:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oy4 | CHIMERA PROTEIN OFCALMODULIN, GPF-LIKEPROTEIN EOSFP, ANDMYOSIN LIGHT CHAINKINASE (Gallus gallus;Rattusnorvegicus;Lobophylliahemprichii) |
PF01353(GFP)PF13499(EF-hand_7) | 6 | SER A 332PHE A 180GLY A 162THR A 161THR A 183GLU A 151 | GOL A 504 ( 3.9A)NoneNoneNoneGOL A 504 (-2.8A)None | 1.35A | 2zifA-4oy4A:undetectable | 2zifA-4oy4A:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r27 | GLYCOSIDE HYDROLASE (Microbacteriumsp. Gsoil167) |
PF00232(Glyco_hydro_1) | 5 | ALA A 230PRO A 173GLY A 223THR A 220LEU A 228 | None | 1.19A | 2zifA-4r27A:undetectable | 2zifA-4r27A:24.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rku | PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A2 (Pisum sativum) |
PF00223(PsaA_PsaB) | 5 | SER B 666GLY B 660THR B 659LEU B 710VAL B 711 | PQN B5002 (-3.2A)NoneCLA B9023 ( 3.7A)NoneCLA B1239 ( 4.0A) | 1.13A | 2zifA-4rkuB:undetectable | 2zifA-4rkuB:16.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u7t | DNA(CYTOSINE-5)-METHYLTRANSFERASE 3A (Homo sapiens) |
PF00145(DNA_methylase) | 5 | PRO A 709PHE A 640GLY A 642THR A 645GLU A 664 | SAH A1004 ( 3.9A)SAH A1004 (-4.6A)SAH A1004 (-3.3A)SAH A1004 (-3.3A)SAH A1004 (-3.0A) | 0.73A | 2zifA-4u7tA:undetectable | 2zifA-4u7tA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | PRO A 203PHE A 212GLY A 124GLU A 147VAL A 152 | MTA A 401 (-4.1A)NoneMTA A 401 (-3.5A)MTA A 401 (-2.7A)MTA A 401 (-4.3A) | 1.18A | 2zifA-4uoeA:2.4 | 2zifA-4uoeA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xqk | LLABIII (Lactococcuslactis) |
PF00271(Helicase_C)PF02384(N6_Mtase)PF04851(ResIII)PF13156(Mrr_cat_2) | 8 | PRO A1020PHE A 910PHE A 904GLY A 906THR A 907THR A 909GLU A 944VAL A 946 | None | 1.25A | 2zifA-4xqkA:2.7 | 2zifA-4xqkA:11.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bsz | N-METHYLTRANSFERASE (Streptoalloteichussp. ATCC 53650) |
PF13649(Methyltransf_25) | 5 | ALA A 95GLY A 55THR A 56GLU A 74LEU A 75 | EDO A 304 (-4.5A)SAH A 301 ( 3.7A)NoneSAH A 301 (-2.9A)SAH A 301 (-3.9A) | 1.15A | 2zifA-5bszA:3.2 | 2zifA-5bszA:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c2c | FORM II RUBISCO (Gallionella) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 5 | ALA A 413PHE A 183GLY A 395THR A 163LEU A 374 | None | 1.08A | 2zifA-5c2cA:undetectable | 2zifA-5c2cA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ex8 | CYTOCHROME P450 (Streptomycestoyocaensis) |
PF00067(p450) | 5 | PHE A 186PHE A 228GLY A 224THR A 223LEU A 85 | NoneEDO A 402 (-4.2A)EDO A 415 (-3.7A)EDO A 415 ( 4.3A)HEM A 401 (-3.9A) | 1.24A | 2zifA-5ex8A:undetectable | 2zifA-5ex8A:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ffj | ENDONUCLEASE ANDMETHYLASE LLAGI (Lactococcuslactis) |
PF00271(Helicase_C)PF02384(N6_Mtase)PF04851(ResIII) | 7 | PRO A1020PHE A 904GLY A 906THR A 907THR A 909GLU A 944VAL A 946 | None | 0.64A | 2zifA-5ffjA:2.6 | 2zifA-5ffjA:12.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ffj | ENDONUCLEASE ANDMETHYLASE LLAGI (Lactococcuslactis) |
PF00271(Helicase_C)PF02384(N6_Mtase)PF04851(ResIII) | 7 | PRO A1020PHE A 910PHE A 904GLY A 906THR A 907THR A 909VAL A 946 | None | 1.26A | 2zifA-5ffjA:2.6 | 2zifA-5ffjA:12.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gj4 | SERINE PROTEASESUBUNIT NS2BSERINE PROTEASE NS3 (Zika virus;Zika virus) |
PF01002(Flavi_NS2B)PF00949(Peptidase_S7) | 5 | ALA B 164SER A 85PHE A 84GLY A 128THR A 127 | None | 1.18A | 2zifA-5gj4B:undetectable | 2zifA-5gj4B:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gl9 | BETA-LACTAMASE (Burkholderiathailandensis) |
PF13354(Beta-lactamase2) | 6 | ALA A 283PRO A 67PHE A 66GLY A 244THR A 243THR A 266 | None | 1.35A | 2zifA-5gl9A:undetectable | 2zifA-5gl9A:23.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hfj | ADENINE SPECIFIC DNAMETHYLTRANSFERASE(DPNA) (Helicobacterpylori) |
PF01555(N6_N4_Mtase) | 6 | ALA A 9PRO A 31PHE A 195GLY A 197THR A 200GLU A 216 | SAM A 301 (-3.2A)SAM A 301 ( 4.0A)SAM A 301 (-4.6A)SAM A 301 (-3.4A)SAM A 301 (-3.6A)SAM A 301 (-3.1A) | 0.55A | 2zifA-5hfjA:19.5 | 2zifA-5hfjA:26.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j9r | CHOLOYLGLYCINEHYDROLASE (Agrobacteriumtumefaciens) |
PF02275(CBAH) | 5 | SER A 211PHE A 207THR A 2THR A 173VAL A 259 | None | 1.21A | 2zifA-5j9rA:undetectable | 2zifA-5j9rA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jyg | ACTIN-LIKE ATPASE (Magnetospirillummagneticum) |
PF06723(MreB_Mbl) | 5 | ALA A 253SER A 222GLY A 225THR A 226THR A 228 | NoneADP A 402 (-3.5A)NoneNoneNone | 1.15A | 2zifA-5jygA:undetectable | 2zifA-5jygA:26.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l1t | PENTALENOLACTONESYNTHASE (Streptomycesarenae) |
PF00067(p450) | 5 | PHE A 391GLY A 244THR A 245LEU A 273VAL A 269 | None | 1.12A | 2zifA-5l1tA:undetectable | 2zifA-5l1tA:24.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l3r | SIGNAL RECOGNITIONPARTICLE 54 KDAPROTEIN,CHLOROPLASTIC (Arabidopsisthaliana) |
PF00448(SRP54)PF02881(SRP54_N) | 5 | ALA A 334SER A 167GLY A 319THR A 318VAL A 295 | None | 1.24A | 2zifA-5l3rA:undetectable | 2zifA-5l3rA:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l9w | ACETOPHENONECARBOXYLASE ALPHASUBUNIT (Aromatoleumaromaticum) |
PF01968(Hydantoinase_A)PF05378(Hydant_A_N) | 5 | ALA b 313SER b 334GLY b 317THR b 354THR b 352 | NoneNoneADP b 801 ( 4.0A)ADP b 801 (-3.8A)None | 1.24A | 2zifA-5l9wb:undetectable | 2zifA-5l9wb:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lc8 | ARACHIDONATE15-LIPOXYGENASE (Pseudomonasaeruginosa) |
PF00305(Lipoxygenase) | 5 | ALA A 496SER A 505GLY A 536THR A 535THR A 510 | None | 1.18A | 2zifA-5lc8A:undetectable | 2zifA-5lc8A:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n6v | AMYLOSUCRASE (Neisseriapolysaccharea) |
no annotation | 5 | PRO A 514GLY A 487THR A 492THR A 450GLU A 489 | None | 1.13A | 2zifA-5n6vA:undetectable | 2zifA-5n6vA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tdx | ANCESTRALHYDROXYNITRILE LYASE1 (syntheticconstruct) |
no annotation | 5 | ALA A 90PRO A 108GLY A 82THR A 11LEU A 88 | NoneNoneNoneGOL A 300 (-2.9A)None | 1.02A | 2zifA-5tdxA:undetectable | 2zifA-5tdxA:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5txe | ATXE2 (Asticcacaulisexcentricus) |
PF00326(Peptidase_S9) | 5 | ALA A 54SER A 440PHE A 416GLY A 349THR A 348 | None | 1.17A | 2zifA-5txeA:2.3 | 2zifA-5txeA:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xj1 | UNCHARACTERIZED RNAMETHYLTRANSFERASESP_1029 (Streptococcuspneumoniae) |
no annotation | 5 | ALA A 361GLY A 314THR A 317GLU A 333LEU A 334 | None | 0.76A | 2zifA-5xj1A:2.1 | 2zifA-5xj1A:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xtw | MACROPHAGE MANNOSERECEPTOR 1 (Homo sapiens) |
no annotation | 5 | ALA A 185PHE A 174GLY A 195THR A 196THR A 197 | None | 1.21A | 2zifA-5xtwA:undetectable | 2zifA-5xtwA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yu1 | LYSINECYCLODEAMINASE (Streptomycespristinaespiralis) |
no annotation | 5 | ALA A 311SER A 126PHE A 299GLY A 303THR A 302 | NoneNoneNoneNAD A 402 ( 3.2A)None | 1.22A | 2zifA-5yu1A:undetectable | 2zifA-5yu1A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6brr | DNA(CYTOSINE-5)-METHYLTRANSFERASE 3A (Homo sapiens) |
no annotation | 5 | PRO A 709PHE A 640GLY A 642THR A 645GLU A 664 | SAH A1001 (-3.7A)SAH A1001 (-4.4A)SAH A1001 (-3.4A)SAH A1001 (-3.5A)SAH A1001 (-2.7A) | 0.55A | 2zifA-6brrA:4.0 | 2zifA-6brrA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cdm | VFP7.04 HEAVY CHAIN (Mus musculus) |
no annotation | 5 | SER A 21GLY A 104THR A 105THR A 107VAL A 102 | None | 1.20A | 2zifA-6cdmA:undetectable | 2zifA-6cdmA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6exs | PEPTIDE ABCTRANSPORTER PERMEASE (Staphylococcushominis) |
no annotation | 5 | ALA A 452SER A 69PHE A 257THR A 263VAL A 269 | None | 1.23A | 2zifA-6exsA:undetectable | 2zifA-6exsA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fos | PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A2 (Cyanidioschyzonmerolae) |
no annotation | 5 | SER B 664GLY B 658THR B 657LEU B 708VAL B 709 | CLA B1023 (-4.5A)NoneCLA B1239 ( 4.4A)NoneCLA B1226 (-4.4A) | 1.13A | 2zifA-6fosB:undetectable | 2zifA-6fosB:undetectable |