SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZIA_B_CL9B401_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e7s GDP-FUCOSE
SYNTHETASE

(Escherichia
coli) 		PF01370
(Epimerase) 		4 ARG A   5
ASP A  57
LEU A  23
ARG A  34
 None
 1.46A 2ziaB-1e7sA:
3.1		 2ziaB-1e7sA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE

(Escherichia
coli) 		PF00982
(Glyco_transf_20) 		4 ARG A 405
ASP A 406
LEU A 412
ARG A 319
 None
 1.45A 2ziaB-1gz5A:
2.3		 2ziaB-1gz5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3g CYCLOMALTODEXTRINASE

(Flavobacterium
sp. 92) 		PF00128
(Alpha-amylase)
PF09087
(Cyc-maltodext_N)
PF10438
(Cyc-maltodext_C) 		4 ARG A 148
ASP A 146
LEU A 170
ARG A 211
 None
CA  A 700 (-3.2A)
None
None
 1.16A 2ziaB-1h3gA:
0.0		 2ziaB-1h3gA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1now BETA-HEXOSAMINIDASE
BETA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 ARG A 528
ASP A 527
LEU A 546
ARG A 512
 None
None
GOL  A 559 (-4.5A)
None
 1.38A 2ziaB-1nowA:
0.0		 2ziaB-1nowA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8o BACTERIAL SIALIDASE

(Micromonospora
viridifaciens) 		PF00754
(F5_F8_type_C)
PF10633
(NPCBM_assoc)
PF13088
(BNR_2) 		4 ARG A  68
ASP A  85
LEU A 384
ARG A 276
 CIT  A1649 ( 2.6A)
None
None
CIT  A1649 ( 2.7A)
 1.35A 2ziaB-1w8oA:
undetectable		 2ziaB-1w8oA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wls L-ASPARAGINASE

(Pyrococcus
horikoshii) 		PF00710
(Asparaginase) 		4 ARG A   2
ASP A  75
LEU A 128
ARG A  45
 None
 1.31A 2ziaB-1wlsA:
0.0		 2ziaB-1wlsA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woy METHIONYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF09334
(tRNA-synt_1g) 		4 ARG A 321
ASP A 318
LEU A 404
ARG A  37
 None
 1.32A 2ziaB-1woyA:
0.8		 2ziaB-1woyA:
19.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a30 DEOXYCYTIDINE KINASE

(Homo sapiens) 		PF01712
(dNK) 		4 ARG A 128
ASP A 133
LEU A 141
ARG A 194
 DCZ  A 302 (-4.1A)
DCZ  A 302 (-3.2A)
None
DCZ  A 302 ( 4.8A)
 0.68A 2ziaB-2a30A:
35.1		 2ziaB-2a30A:
92.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf6 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF13088
(BNR_2) 		4 ARG A 266
ASP A 283
LEU A 669
ARG A 555
 SIA  A1692 (-2.7A)
None
None
SIA  A1692 (-2.9A)
 1.36A 2ziaB-2bf6A:
undetectable		 2ziaB-2bf6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG A 258
ASP A 259
LEU A 275
ARG A 384
 None
 1.28A 2ziaB-2dylA:
undetectable		 2ziaB-2dylA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w20 SIALIDASE A

(Streptococcus
pneumoniae) 		PF13088
(BNR_2) 		4 ARG A 347
ASP A 364
LEU A 766
ARG A 663
 None
 1.33A 2ziaB-2w20A:
undetectable		 2ziaB-2w20A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mml ALLOPHANATE
HYDROLASE SUBUNIT 2

(Mycolicibacterium
smegmatis) 		PF02626
(CT_A_B) 		4 ARG A 208
ASP A 207
LEU A 248
ARG A  21
 None
 1.24A 2ziaB-3mmlA:
undetectable		 2ziaB-3mmlA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		4 ARG A 240
ASP A 241
LEU A 154
ARG A 129
 None
VBN  A   1 ( 4.2A)
None
None
 1.21A 2ziaB-3r5tA:
2.5		 2ziaB-3r5tA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN

(Escherichia
coli) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 ARG A 255
ASP A  42
LEU A 260
ARG A   8
 None
 1.42A 2ziaB-4c7oA:
6.0		 2ziaB-4c7oA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA

(Homo sapiens;
Lymnaea
stagnalis) 		PF02931
(Neur_chan_LBD) 		4 ARG A 179
ASP A 193
LEU A  88
ARG A 150
 None
 1.26A 2ziaB-4hqpA:
undetectable		 2ziaB-4hqpA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxu PUTATIVE
AMINOTRANSFERASE

(Sinorhizobium
meliloti) 		PF01063
(Aminotran_4) 		4 ARG A 280
ASP A 281
LEU A 226
ARG A  45
 None
 1.32A 2ziaB-4jxuA:
undetectable		 2ziaB-4jxuA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		4 ARG A1478
ASP A1480
LEU A1414
ARG A1429
 None
 1.39A 2ziaB-4u48A:
undetectable		 2ziaB-4u48A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ax7 PYRUVYL TRANSFERASE
1

(Schizosaccharomyces
pombe) 		PF04230
(PS_pyruv_trans) 		4 ARG A 217
ASP A 218
LEU A 370
ARG A 337
 None
 1.33A 2ziaB-5ax7A:
undetectable		 2ziaB-5ax7A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fdn PHOSPHOENOLPYRUVATE
CARBOXYLASE 3

(Arabidopsis
thaliana) 		PF00311
(PEPcase) 		4 ARG A 188
ASP A 191
LEU A 107
ARG A 180
 None
 0.89A 2ziaB-5fdnA:
undetectable		 2ziaB-5fdnA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ib0 UNCHARACTERIZED
PROTEIN PA4534

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		4 ARG A  66
ASP A  64
LEU A  96
ARG A 128
 GOL  A 204 (-2.8A)
None
None
GOL  A 204 (-3.2A)
 1.34A 2ziaB-5ib0A:
undetectable		 2ziaB-5ib0A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n77 MAGNESIUM TRANSPORT
PROTEIN CORA

(Escherichia
coli) 		PF01544
(CorA) 		4 ARG A 197
ASP A 194
LEU A 227
ARG A 204
 None
 1.46A 2ziaB-5n77A:
undetectable		 2ziaB-5n77A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fg9 -

(-) 		no annotation 4 ARG A 506
ASP A 444
LEU A 414
ARG A 449
 None
 1.12A 2ziaB-6fg9A:
undetectable		 2ziaB-6fg9A:
undetectable