SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZIA_B_CL9B401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE

(Thermococcus
litoralis) 		PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926) 		5 ILE A  10
VAL A 228
TRP A 233
LEU A 234
PHE A 211
 None
 1.31A 2ziaB-1k1xA:
undetectable		 2ziaB-1k1xA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1osg TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B

(Homo sapiens) 		PF00229
(TNF) 		5 VAL A 166
TRP A 168
LEU A 261
PHE A 278
TYR A 246
 None
 1.27A 2ziaB-1osgA:
undetectable		 2ziaB-1osgA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1osn THYMIDINE KINASE

(Human
alphaherpesvirus
3) 		PF00693
(Herpes_TK) 		5 GLU A  48
TRP A  53
TYR A  66
GLN A  90
PHE A 139
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
BVP  A 500 (-3.7A)
 0.99A 2ziaB-1osnA:
15.8		 2ziaB-1osnA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p75 THYMIDINE KINASE

(Equid
alphaherpesvirus
4) 		PF00693
(Herpes_TK) 		5 GLU A  60
TRP A  65
TYR A  78
GLN A 102
PHE A 148
 T5A  A 501 (-2.5A)
None
T5A  A 501 (-4.6A)
T5A  A 501 (-3.1A)
T5A  A 501 (-3.5A)
 1.05A 2ziaB-1p75A:
15.8		 2ziaB-1p75A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6y ENDO-1,4-BETA-D-XYLA
NASE AND
ENDO-1,4-BETA-XYLANA
SE B

(Cellulomonas
fimi;
Streptomyces
olivaceoviridis) 		PF00331
(Glyco_hydro_10) 		5 GLU A  46
VAL A  67
LEU A  25
TYR A  30
TYR A 281
 None
 1.33A 2ziaB-1v6yA:
undetectable		 2ziaB-1v6yA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vtk THYMIDINE KINASE

(Human
alphaherpesvirus
1) 		PF00693
(Herpes_TK) 		5 GLU A  83
TRP A  88
TYR A 101
GLN A 125
GLU A 225
 TMP  A 500 (-2.7A)
None
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 (-3.5A)
 1.00A 2ziaB-1vtkA:
16.7		 2ziaB-1vtkA:
20.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a30 DEOXYCYTIDINE KINASE

(Homo sapiens) 		PF01712
(dNK) 		12 ILE A  30
GLU A  53
VAL A  55
TRP A  58
LEU A  82
MET A  85
TYR A  86
GLN A  97
ARG A 104
PHE A 137
GLU A 197
TYR A 204
 DCZ  A 302 ( 4.3A)
DCZ  A 302 (-3.0A)
None
None
DCZ  A 302 ( 4.9A)
DCZ  A 302 ( 4.3A)
DCZ  A 302 (-4.6A)
DCZ  A 302 (-3.2A)
None
DCZ  A 302 (-3.8A)
DCZ  A 302 (-3.5A)
None
 0.62A 2ziaB-2a30A:
35.1		 2ziaB-2a30A:
92.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a30 DEOXYCYTIDINE KINASE

(Homo sapiens) 		PF01712
(dNK) 		5 ILE A 200
LEU A  82
MET A  85
GLN A  97
ARG A 128
 None
DCZ  A 302 ( 4.9A)
DCZ  A 302 ( 4.3A)
DCZ  A 302 (-3.2A)
DCZ  A 302 (-4.1A)
 1.23A 2ziaB-2a30A:
35.1		 2ziaB-2a30A:
92.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 ILE A 251
GLU A 192
VAL A 193
ARG A 297
PHE A 292
 None
 1.37A 2ziaB-2f9gA:
undetectable		 2ziaB-2f9gA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jaq DEOXYGUANOSINE
KINASE

(Mycoplasma
mycoides) 		PF01712
(dNK) 		7 VAL A  33
TYR A  43
GLN A  54
ARG A  61
PHE A  86
GLU A 150
TYR A 157
 DCP  A1202 (-4.6A)
None
DCP  A1202 (-2.9A)
None
DCP  A1202 (-3.6A)
DCP  A1202 (-3.5A)
None
 0.81A 2ziaB-2jaqA:
23.5		 2ziaB-2jaqA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcs DEOXYNUCLEOSIDE
KINASE

(Drosophila
melanogaster) 		PF01712
(dNK) 		10 ILE A  29
VAL A  54
TRP A  57
LEU A  66
MET A  69
TYR A  70
GLN A  81
PHE A 114
GLU A 172
TYR A 179
 TTP  A1210 (-3.9A)
TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.5A)
TTP  A1210 (-3.6A)
None
 0.75A 2ziaB-2jcsA:
26.6		 2ziaB-2jcsA:
28.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		5 GLU A  70
VAL A  72
TRP A  75
MET A  99
GLN A 111
 None
DTP  A 301 (-4.1A)
None
DTP  A 301 ( 3.9A)
DTP  A 301 (-2.9A)
 1.15A 2ziaB-2ocpA:
32.2		 2ziaB-2ocpA:
44.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		10 ILE A  47
VAL A  72
TRP A  75
LEU A  96
MET A  99
TYR A 100
GLN A 111
PHE A 151
GLU A 211
TYR A 218
 DTP  A 301 (-3.8A)
DTP  A 301 (-4.1A)
None
DTP  A 301 (-4.6A)
DTP  A 301 ( 3.9A)
DTP  A 301 (-4.5A)
DTP  A 301 (-2.9A)
DTP  A 301 (-3.3A)
DTP  A 301 (-3.5A)
None
 0.54A 2ziaB-2ocpA:
32.2		 2ziaB-2ocpA:
44.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		8 ILE A  47
VAL A  72
TRP A  75
LEU A  96
TYR A 100
ARG A 118
GLU A 211
TYR A 218
 DTP  A 301 (-3.8A)
DTP  A 301 (-4.1A)
None
DTP  A 301 (-4.6A)
DTP  A 301 (-4.5A)
DTP  A 301 (-3.1A)
DTP  A 301 (-3.5A)
None
 0.64A 2ziaB-2ocpA:
32.2		 2ziaB-2ocpA:
44.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr5 GLYCOGEN OPERON
PROTEIN GLGX

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 VAL A 219
LEU A 211
MET A 207
TYR A 210
PHE A 566
 None
 1.46A 2ziaB-2vr5A:
undetectable		 2ziaB-2vr5A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy8 POLYMERASE BASIC
PROTEIN 2

(Influenza A
virus) 		PF00604
(Flu_PB2) 		5 ILE A 647
VAL A 640
TYR A 550
GLN A 581
PHE A 621
 None
 1.24A 2ziaB-2vy8A:
undetectable		 2ziaB-2vy8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8h PUTATIVE POLYKETIDE
CYCLASE

(Ruegeria sp.
TM1040) 		PF12680
(SnoaL_2) 		5 VAL A  28
LEU A  24
MET A  20
TYR A   8
PHE A  47
 None
None
MRD  A 135 ( 3.9A)
None
None
 1.45A 2ziaB-3f8hA:
undetectable		 2ziaB-3f8hA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III

(Burkholderia
pseudomallei) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ILE A  15
LEU A 128
TYR A 124
ARG A 184
PHE A 344
 None
 1.33A 2ziaB-3gweA:
1.3		 2ziaB-3gweA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ide CAPSID PROTEIN VP2

(Infectious
pancreatic
necrosis virus) 		PF01766
(Birna_VP2) 		5 ILE A 402
TRP A 415
LEU A 166
ARG A 423
PHE A 427
 None
 1.40A 2ziaB-3ideA:
undetectable		 2ziaB-3ideA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khw POLYMERASE PB2

(Influenza A
virus) 		PF00604
(Flu_PB2) 		5 ILE A 647
VAL A 640
TYR A 550
GLN A 581
PHE A 621
 None
 1.11A 2ziaB-3khwA:
undetectable		 2ziaB-3khwA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldr FRUCTOSYLTRANSFERASE

(Aspergillus
japonicus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 GLU A 602
VAL A 595
LEU A 475
TYR A 647
TYR A  95
 None
 1.24A 2ziaB-3ldrA:
undetectable		 2ziaB-3ldrA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tac LIPRIN-ALPHA-2

(Homo sapiens) 		PF00536
(SAM_1)
PF07647
(SAM_2) 		5 ILE B 939
TRP B 906
LEU B 907
MET B 913
TYR B 917
 None
 1.13A 2ziaB-3tacB:
undetectable		 2ziaB-3tacB:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tac LIPRIN-ALPHA-2

(Homo sapiens) 		PF00536
(SAM_1)
PF07647
(SAM_2) 		5 ILE B 943
VAL B 903
TRP B 906
LEU B 907
MET B 913
 None
 1.17A 2ziaB-3tacB:
undetectable		 2ziaB-3tacB:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tad LIPRIN-ALPHA-2

(Homo sapiens) 		PF00536
(SAM_1)
PF07647
(SAM_2) 		5 ILE A 939
TRP A 906
LEU A 907
MET A 913
TYR A 917
 None
 1.13A 2ziaB-3tadA:
undetectable		 2ziaB-3tadA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tad LIPRIN-ALPHA-2

(Homo sapiens) 		PF00536
(SAM_1)
PF07647
(SAM_2) 		5 ILE A 943
VAL A 903
TRP A 906
LEU A 907
MET A 913
 None
 1.29A 2ziaB-3tadA:
undetectable		 2ziaB-3tadA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF02156
(Glyco_hydro_26)
PF16990
(CBM_35) 		5 ILE A 122
GLU A  15
VAL A  24
LEU A  19
PHE A  49
 None
CA  A1450 (-2.4A)
None
None
None
 1.43A 2ziaB-3zm8A:
undetectable		 2ziaB-3zm8A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9x COPPER HOMEOSTASIS
PROTEIN CUTC

(Bacillus
anthracis) 		PF03932
(CutC) 		5 ILE A   5
VAL A 174
LEU A 145
GLU A  24
TYR A  29
 None
 1.38A 2ziaB-4r9xA:
undetectable		 2ziaB-4r9xA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v36 LYSYL-TRNA-DEPENDENT
L-YSYL-PHOSPHATIDYLG
YCEROL SYNTHASE

(Bacillus
licheniformis) 		PF09924
(DUF2156) 		5 GLU A 668
VAL A 713
LEU A 680
GLN A 707
GLU A 679
 None
 1.06A 2ziaB-4v36A:
undetectable		 2ziaB-4v36A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7l CAS6B

(Methanococcus
maripaludis) 		PF17262
(DUF5328) 		5 ILE A  79
LEU A  85
TYR A  10
PHE A  54
GLU A  82
 None
 1.36A 2ziaB-4z7lA:
undetectable		 2ziaB-4z7lA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zch TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B

(Homo sapiens) 		PF00229
(TNF) 		5 VAL A 174
TRP A 176
LEU A 269
PHE A 286
TYR A 254
 None
 1.28A 2ziaB-4zchA:
undetectable		 2ziaB-4zchA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zch TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B

(Homo sapiens) 		PF00229
(TNF) 		5 VAL A 325
TRP A 327
LEU A 420
PHE A 437
TYR A 405
 None
 1.29A 2ziaB-4zchA:
undetectable		 2ziaB-4zchA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4w PLEXIN-B1

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI) 		5 VAL A 208
LEU A 206
TYR A 261
PHE A 218
GLU A 263
 None
 1.47A 2ziaB-5b4wA:
undetectable		 2ziaB-5b4wA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 ILE A 218
VAL A  58
LEU A 345
ARG A 156
PHE A 503
 None
 1.25A 2ziaB-5ck0A:
undetectable		 2ziaB-5ck0A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5itg SORBITOL
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 ILE A 125
GLU A  41
VAL A  45
LEU A 276
MET A 283
 None
 1.49A 2ziaB-5itgA:
undetectable		 2ziaB-5itgA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 ILE B 689
VAL B 259
GLN B 518
ARG B 424
TYR B 656
 None
 1.17A 2ziaB-5nd1B:
undetectable		 2ziaB-5nd1B:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vnc GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2

(Saccharomyces
cerevisiae) 		no annotation 5 VAL A  17
TRP A  95
LEU A  45
TYR A  43
GLU A  12
 None
 1.47A 2ziaB-5vncA:
1.7		 2ziaB-5vncA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Homo sapiens) 		PF06212
(GRIM-19) 		6 ILE w  66
LEU w 114
TYR w 118
GLN w 132
GLU w 226
TYR w 233
 None
 1.12A 2ziaB-5xtdw:
18.4		 2ziaB-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Homo sapiens) 		PF06212
(GRIM-19) 		6 ILE w  66
TYR w 118
ARG w 139
PHE w 169
GLU w 226
TYR w 233
 None
 1.50A 2ziaB-5xtdw:
18.4		 2ziaB-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Homo sapiens) 		PF06212
(GRIM-19) 		6 ILE w  66
TYR w 118
GLN w 132
ARG w 139
GLU w 226
TYR w 233
 None
 1.08A 2ziaB-5xtdw:
18.4		 2ziaB-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Mus musculus) 		no annotation 6 ILE O  31
GLU O  53
LEU O  79
TYR O  83
ARG O 104
GLU O 191
 ADP  O 401 (-4.0A)
ADP  O 401 ( 4.7A)
None
ADP  O 401 (-4.9A)
ADP  O 401 (-4.5A)
ADP  O 401 (-3.2A)
 1.06A 2ziaB-6g2jO:
undetectable		 2ziaB-6g2jO:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Mus musculus) 		no annotation 8 ILE O  31
GLU O  53
LEU O  79
TYR O  83
GLN O  97
PHE O 134
GLU O 191
TYR O 198
 ADP  O 401 (-4.0A)
ADP  O 401 ( 4.7A)
None
ADP  O 401 (-4.9A)
ADP  O 401 (-3.5A)
ADP  O 401 (-3.6A)
ADP  O 401 (-3.2A)
None
 1.01A 2ziaB-6g2jO:
undetectable		 2ziaB-6g2jO:
13.98