SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZIA_A_CL9A401_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		4 VAL A 218
ASP A 794
LEU A 205
ARG A 805
 None
 1.48A 2ziaA-1c7tA:
undetectable		 2ziaA-1c7tA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 VAL B 820
ASP B 470
LEU B 867
ARG B 848
 None
 1.46A 2ziaA-1gl9B:
undetectable		 2ziaA-1gl9B:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnz GSI-B4 ISOLECTIN

(Griffonia
simplicifolia) 		PF00139
(Lectin_legB) 		4 VAL A 187
ASP A 164
LEU A  79
ARG A 174
 None
None
None
PO4  A1241 (-4.0A)
 1.46A 2ziaA-1gnzA:
undetectable		 2ziaA-1gnzA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jbk CLPB PROTEIN

(Escherichia
coli) 		PF00004
(AAA) 		4 VAL A 338
ASP A 278
LEU A 168
ARG A 183
 None
 1.31A 2ziaA-1jbkA:
1.7		 2ziaA-1jbkA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF06087
(Tyr-DNA_phospho) 		4 VAL A 171
ASP A 187
LEU A 298
ARG A 487
 None
 1.39A 2ziaA-1jy1A:
undetectable		 2ziaA-1jy1A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhg ATP-DEPENDENT
HELICASE PCRA

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 VAL A  97
ASP A 191
LEU A 185
ARG A 101
 None
 1.49A 2ziaA-1qhgA:
1.3		 2ziaA-1qhgA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhh PROTEIN (PCRA
(SUBUNIT))

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 VAL A  97
ASP B 191
LEU B 185
ARG A 101
 None
 1.50A 2ziaA-1qhhA:
undetectable		 2ziaA-1qhhA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmo VITELLINE MEMBRANE
OUTER LAYER PROTEIN
I

(Gallus gallus) 		PF03762
(VOMI) 		4 VAL A  78
ASP A 119
LEU A  50
ARG A  56
 None
 1.15A 2ziaA-1vmoA:
undetectable		 2ziaA-1vmoA:
18.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a30 DEOXYCYTIDINE KINASE

(Homo sapiens) 		PF01712
(dNK) 		4 VAL A  55
ASP A 133
LEU A 141
ARG A 194
 None
DCZ  A 302 (-3.2A)
None
DCZ  A 302 ( 4.8A)
 0.55A 2ziaA-2a30A:
36.0		 2ziaA-2a30A:
92.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8b RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE R

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 VAL A 502
ASP A 474
LEU A 434
ARG A 420
 None
 1.27A 2ziaA-2a8bA:
undetectable		 2ziaA-2a8bA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01019
(G_glu_transpept) 		4 VAL A 230
ASP A 301
LEU A 384
ARG A 226
 None
 0.96A 2ziaA-2i3oA:
undetectable		 2ziaA-2i3oA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 VAL A 169
ASP A 151
LEU A 139
ARG A 175
 None
AGS  A3001 (-2.8A)
None
None
 1.24A 2ziaA-2pmiA:
undetectable		 2ziaA-2pmiA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wny CONSERVED PROTEIN
MTH689

(Methanothermobacter
thermautotrophicus) 		PF01877
(RNA_binding) 		4 VAL A  51
ASP A 111
LEU A  94
ARG A  53
 None
 1.07A 2ziaA-2wnyA:
undetectable		 2ziaA-2wnyA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6c MATRILYSIN

(Homo sapiens) 		PF00413
(Peptidase_M10) 		4 VAL A 152
ASP A 194
LEU A 225
ARG A 150
 None
CA  A1264 (-3.0A)
None
None
 1.17A 2ziaA-2y6cA:
2.3		 2ziaA-2y6cA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE

(Pseudomonas
putida) 		PF13489
(Methyltransf_23) 		4 VAL A  27
ASP A  82
LEU A  12
ARG A  35
 None
None
SAH  A 300 ( 4.8A)
SAH  A 300 (-2.9A)
 1.31A 2ziaA-3e8sA:
undetectable		 2ziaA-3e8sA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5k PEPTIDE DEFORMYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01327
(Pep_deformylase) 		4 VAL A  24
ASP A 136
LEU A  92
ARG A  62
 None
 1.29A 2ziaA-3g5kA:
undetectable		 2ziaA-3g5kA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg0 KLEBSIELLA
PNEUMONIAE BLRP1

(Klebsiella
pneumoniae) 		PF00563
(EAL)
PF04940
(BLUF) 		4 VAL A 121
ASP A 103
LEU A  97
ARG A 127
 None
 1.01A 2ziaA-3gg0A:
undetectable		 2ziaA-3gg0A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcm PUTATIVE
OXIDOREDUCTASE

(Streptococcus
mutans) 		PF02525
(Flavodoxin_2) 		4 VAL A  61
ASP A  69
LEU A   4
ARG A  98
 None
 1.36A 2ziaA-3lcmA:
3.0		 2ziaA-3lcmA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdu N-FORMIMINO-L-GLUTAM
ATE IMINOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		4 VAL A 240
ASP A 300
LEU A 290
ARG A 250
 None
 1.07A 2ziaA-3mduA:
undetectable		 2ziaA-3mduA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3noj 4-CARBOXY-4-HYDROXY-
2-OXOADIPATE
ALDOLASE/OXALOACETAT
E DECARBOXYLASE

(Pseudomonas
putida) 		PF03737
(RraA-like) 		4 VAL A 179
ASP A 119
LEU A  65
ARG A 181
 None
 1.48A 2ziaA-3nojA:
undetectable		 2ziaA-3nojA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE

(Streptomyces
coelicolor) 		PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5) 		4 VAL A  81
ASP A 140
LEU A  95
ARG A  57
 None
 1.50A 2ziaA-3zgjA:
undetectable		 2ziaA-3zgjA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		4 VAL A 376
ASP A 241
LEU A 281
ARG A 335
 None
 1.18A 2ziaA-4c02A:
undetectable		 2ziaA-4c02A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ciu CHAPERONE PROTEIN
CLPB

(Escherichia
coli) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 VAL A 338
ASP A 278
LEU A 168
ARG A 183
 None
ADP  A 901 ( 4.9A)
None
None
 1.32A 2ziaA-4ciuA:
undetectable		 2ziaA-4ciuA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hse CHAPERONE PROTEIN
CLPB

(Thermus
thermophilus) 		PF00004
(AAA) 		4 VAL A 329
ASP A 270
LEU A 160
ARG A 175
 None
ADP  A 602 ( 4.8A)
None
None
 1.34A 2ziaA-4hseA:
undetectable		 2ziaA-4hseA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvl FATTY ACID
ALPHA-OXIDASE

(Oryza sativa) 		PF03098
(An_peroxidase) 		4 VAL A 113
ASP A 528
LEU A 533
ARG A 494
 None
 1.35A 2ziaA-4kvlA:
undetectable		 2ziaA-4kvlA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oiv BILE ACID RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 VAL A 301
ASP A 262
LEU A 257
ARG A 335
 None
 1.14A 2ziaA-4oivA:
undetectable		 2ziaA-4oivA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB

(Lactococcus
lactis) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		4 VAL A 348
ASP A 340
LEU A 335
ARG A 720
 None
 1.30A 2ziaA-4wd9A:
undetectable		 2ziaA-4wd9A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwa ORNITHINE
DECARBOXYLASE
ORNITHINE
DECARBOXYLASE
ANTIZYME 1

(Homo sapiens) 		PF00278
(Orn_DAP_Arg_deC)
PF02100
(ODC_AZ)
PF02784
(Orn_Arg_deC_N) 		4 VAL B 158
ASP A 134
LEU A 151
ARG B 100
 None
 1.40A 2ziaA-5bwaB:
undetectable		 2ziaA-5bwaB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0u MATRIX
METALLOPROTEINASE-14

(Homo sapiens) 		PF00413
(Peptidase_M10) 		4 VAL A 162
ASP A 212
LEU A 245
ARG A 160
 None
CA  A 301 ( 3.0A)
None
None
 1.05A 2ziaA-5h0uA:
2.6		 2ziaA-5h0uA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6b PUTATIVE SECRETED
LIPASE

(Streptomyces
sp. W007) 		PF01674
(Lipase_2) 		4 VAL A 219
ASP A 239
LEU A  49
ARG A 217
 None
 0.98A 2ziaA-5h6bA:
2.8		 2ziaA-5h6bA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5li8 PUTATIVE CYTOCHROME
P450 126

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 VAL A 375
ASP A 125
LEU A 161
ARG A 374
 None
 1.41A 2ziaA-5li8A:
undetectable		 2ziaA-5li8A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uib OXIDOREDUCTASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF01408
(GFO_IDH_MocA) 		4 VAL A  46
ASP A  72
LEU A  83
ARG A  42
 None
 1.17A 2ziaA-5uibA:
2.0		 2ziaA-5uibA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		4 VAL A 429
ASP A 433
LEU A 439
ARG A 449
 None
 1.39A 2ziaA-5wwtA:
undetectable		 2ziaA-5wwtA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo sapiens) 		no annotation 4 VAL A 462
ASP A 456
LEU A 391
ARG A 466
 None
 1.26A 2ziaA-6fn1A:
1.3		 2ziaA-6fn1A:
11.49