SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZI9_A_CL9A401_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b6u P58 KILLER CELL
INHIBITORY RECEPTOR

(Homo sapiens) 		PF00047
(ig) 		3 ASP A 163
PHE A 164
LEU A 166
 None
 0.59A 2zi9A-1b6uA:
undetectable		 2zi9A-1b6uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)

(Malus domestica) 		PF00155
(Aminotran_1_2) 		3 ASP A 222
PHE A 219
LEU A 215
 None
 0.59A 2zi9A-1b8gA:
1.1		 2zi9A-1b8gA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bht HEPATOCYTE GROWTH
FACTOR

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle) 		3 ASP A 117
PHE A  89
LEU A  97
 None
 0.74A 2zi9A-1bhtA:
undetectable		 2zi9A-1bhtA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci9 PROTEIN
(CARBOXYLESTERASE)

(Burkholderia
gladioli) 		PF00144
(Beta-lactamase) 		3 ASP A  23
PHE A  26
LEU A  30
 None
 0.42A 2zi9A-1ci9A:
undetectable		 2zi9A-1ci9A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8w NADH PEROXIDASE

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 ASP A 190
PHE A 193
LEU A 197
 None
 0.69A 2zi9A-1f8wA:
undetectable		 2zi9A-1f8wA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im9 KILLER CELL
IMMUNOGLOBULIN-LIKE
RECEPTOR 2DL1

(Homo sapiens) 		PF00047
(ig) 		3 ASP D 163
PHE D 164
LEU D 166
 None
 0.67A 2zi9A-1im9D:
undetectable		 2zi9A-1im9D:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsd HAEMAGGLUTININ (HA2
CHAIN)

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 ASP B 133
PHE B 138
LEU B 140
 None
 0.71A 2zi9A-1jsdB:
undetectable		 2zi9A-1jsdB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhs PLASMA MEMBRANE
ATPASE

(Neurospora
crassa) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		3 ASP A 423
PHE A 426
LEU A 430
 None
 0.64A 2zi9A-1mhsA:
undetectable		 2zi9A-1mhsA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		3 ASP A  64
PHE A  63
LEU A  32
 None
 0.64A 2zi9A-1o2dA:
undetectable		 2zi9A-1o2dA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5l TRANSCRIPTIONAL
REGULATOR, CRP
FAMILY

(Thermotoga
maritima) 		PF00027
(cNMP_binding) 		3 ASP A 111
PHE A 108
LEU A 104
 None
 0.44A 2zi9A-1o5lA:
undetectable		 2zi9A-1o5lA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zca G ALPHA I/12

(Mus musculus) 		PF00503
(G-alpha) 		3 ASP A  93
PHE A  96
LEU A 100
 None
 0.30A 2zi9A-1zcaA:
6.1		 2zi9A-1zcaA:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a30 DEOXYCYTIDINE KINASE

(Homo sapiens) 		PF01712
(dNK) 		3 ASP A 133
PHE A 137
LEU A 141
 DCZ  A 302 (-3.2A)
DCZ  A 302 (-3.8A)
None
 0.34A 2zi9A-2a30A:
34.6		 2zi9A-2a30A:
92.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azq CATECHOL
1,2-DIOXYGENASE

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		3 ASP A 286
PHE A 287
LEU A 289
 None
 0.62A 2zi9A-2azqA:
undetectable		 2zi9A-2azqA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e30 CALCIUM-BINDING
PROTEIN P22

(Homo sapiens) 		PF13499
(EF-hand_7) 		3 ASP A  50
PHE A  51
LEU A  57
 None
 0.74A 2zi9A-2e30A:
undetectable		 2zi9A-2e30A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		3 ASP X 560
PHE X 563
LEU X 567
 None
 0.46A 2zi9A-2epkX:
2.2		 2zi9A-2epkX:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ASP A 403
PHE A 404
LEU A 359
 None
 0.55A 2zi9A-2fqdA:
undetectable		 2zi9A-2fqdA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpj SIDEROPHORE-INTERACT
ING PROTEIN

(Shewanella
putrefaciens) 		PF04954
(SIP)
PF08021
(FAD_binding_9) 		3 ASP A  73
PHE A  74
LEU A  76
 EDO  A 502 ( 3.6A)
None
None
 0.68A 2zi9A-2gpjA:
undetectable		 2zi9A-2gpjA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsl HYPOTHETICAL PROTEIN

(Fusobacterium
nucleatum) 		PF00636
(Ribonuclease_3) 		3 ASP A  23
PHE A  20
LEU A  16
 MG  A 201 (-3.3A)
None
None
 0.74A 2zi9A-2gslA:
undetectable		 2zi9A-2gslA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jrp PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF07191
(zinc-ribbons_6) 		3 ASP A  27
PHE A  28
LEU A  30
 None
 0.54A 2zi9A-2jrpA:
undetectable		 2zi9A-2jrpA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mxp CALCIUM-BINDING AND
COILED-COIL
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		no annotation 3 ASP A  74
PHE A  77
LEU A  81
 None
 0.66A 2zi9A-2mxpA:
undetectable		 2zi9A-2mxpA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASP A1297
PHE A1298
LEU A1300
 None
 0.63A 2zi9A-2nlkA:
undetectable		 2zi9A-2nlkA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rh3 PROTEIN VIRC2

(Agrobacterium
tumefaciens) 		PF07181
(VirC2) 		3 ASP A 122
PHE A 193
LEU A 190
 None
 0.73A 2zi9A-2rh3A:
undetectable		 2zi9A-2rh3A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmp MUCOROPEPSIN

(Rhizomucor
miehei) 		PF00026
(Asp) 		3 ASP A  32
PHE A  33
LEU A  35
 None
 0.73A 2zi9A-2rmpA:
undetectable		 2zi9A-2rmpA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		3 ASP B 587
PHE B 588
LEU B 598
 None
 0.57A 2zi9A-2uzxB:
undetectable		 2zi9A-2uzxB:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6e PROTELEMORASE

(Klebsiella
phage phiKO2) 		PF16684
(Telomere_res) 		3 ASP A 407
PHE A 410
LEU A 414
 None
 0.67A 2zi9A-2v6eA:
undetectable		 2zi9A-2v6eA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhy 6-PHOSPHO-BETA-GLUCO
SIDASE BGLA

(Escherichia
coli) 		PF00232
(Glyco_hydro_1) 		3 ASP A 115
PHE A 118
LEU A 122
 None
 0.38A 2zi9A-2xhyA:
undetectable		 2zi9A-2xhyA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		3 ASP A  99
PHE A 102
LEU A 106
 None
 0.42A 2zi9A-2z1aA:
undetectable		 2zi9A-2z1aA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgi PUTATIVE
4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Thermus
thermophilus) 		PF01063
(Aminotran_4) 		3 ASP A  59
PHE A  62
LEU A  66
 None
 0.66A 2zi9A-2zgiA:
undetectable		 2zi9A-2zgiA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfj 1,3-PROPANEDIOL
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF00465
(Fe-ADH) 		3 ASP A  70
PHE A  69
LEU A  37
 None
 0.73A 2zi9A-3bfjA:
undetectable		 2zi9A-3bfjA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3frw PUTATIVE TRP
REPRESSOR PROTEIN

(Blautia obeum) 		PF01371
(Trp_repressor) 		3 ASP A  11
PHE A  14
LEU A  18
 None
 0.29A 2zi9A-3frwA:
undetectable		 2zi9A-3frwA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gra TRANSCRIPTIONAL
REGULATOR, ARAC
FAMILY

(Pseudomonas
putida) 		PF01965
(DJ-1_PfpI) 		3 ASP A  33
PHE A  34
LEU A  36
 None
 0.57A 2zi9A-3graA:
undetectable		 2zi9A-3graA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8n KILLER CELL
IMMUNOGLOBULIN-LIKE
RECEPTOR 2DS4

(Homo sapiens) 		PF00047
(ig) 		3 ASP A 163
PHE A 164
LEU A 166
 None
 0.62A 2zi9A-3h8nA:
undetectable		 2zi9A-3h8nA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm2 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE

(Corynebacterium
diphtheriae) 		no annotation 3 ASP A  28
PHE A  96
LEU A 120
 None
 0.54A 2zi9A-3hm2A:
undetectable		 2zi9A-3hm2A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibz PUTATIVE TELLURIUM
RESISTANT LIKE
PROTEIN TERD

(Streptomyces
coelicolor) 		PF02342
(TerD) 		3 ASP A  38
PHE A  39
LEU A  41
 None
 0.68A 2zi9A-3ibzA:
undetectable		 2zi9A-3ibzA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j04 MYOSIN REGULATORY
LIGHT CHAIN 2,
SMOOTH MUSCLE MAJOR
ISOFORM

(Gallus gallus) 		PF13405
(EF-hand_6)
PF13833
(EF-hand_8) 		3 ASP B  26
PHE B  25
LEU B  93
 None
 0.69A 2zi9A-3j04B:
undetectable		 2zi9A-3j04B:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT

(Methanosarcina
mazei) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		3 ASP A 519
PHE A 520
LEU A 522
 None
 0.71A 2zi9A-3khkA:
undetectable		 2zi9A-3khkA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kor POSSIBLE TRP
REPRESSOR

(Staphylococcus
aureus) 		PF01371
(Trp_repressor) 		3 ASP A  12
PHE A  15
LEU A  19
 None
 0.34A 2zi9A-3korA:
undetectable		 2zi9A-3korA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1a PUTATIVE
DEHYDROGENASE

(Streptomyces
avermitilis) 		PF00106
(adh_short) 		3 ASP A 250
PHE A 139
LEU A 255
 None
 0.70A 2zi9A-3m1aA:
3.5		 2zi9A-3m1aA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn8 LP15968P

(Drosophila
melanogaster) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		3 ASP A 413
PHE A 414
LEU A 416
 None
 0.69A 2zi9A-3mn8A:
2.4		 2zi9A-3mn8A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE GAMMA-SUBUNIT

(Komagataella
pastoris) 		no annotation 3 ASP I 106
PHE I 103
LEU I  99
 None
 0.61A 2zi9A-3opyI:
undetectable		 2zi9A-3opyI:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE

(Thermoplasma
acidophilum) 		PF01494
(FAD_binding_3) 		3 ASP A 198
PHE A 199
LEU A 201
 None
OZ2  A 502 ( 3.8A)
None
 0.73A 2zi9A-3oz2A:
undetectable		 2zi9A-3oz2A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qom 6-PHOSPHO-BETA-GLUCO
SIDASE

(Lactobacillus
plantarum) 		PF00232
(Glyco_hydro_1) 		3 ASP A 115
PHE A 118
LEU A 122
 None
 0.46A 2zi9A-3qomA:
undetectable		 2zi9A-3qomA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpf MOLYBDOPTERIN
SYNTHASE CATALYTIC
SUBUNIT

(Helicobacter
pylori) 		PF02391
(MoaE) 		3 ASP A 111
PHE A 108
LEU A 104
 None
 0.73A 2zi9A-3rpfA:
undetectable		 2zi9A-3rpfA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3smv S-(-)-AZETIDINE-2-CA
RBOXYLATE HYDROLASE

(Pseudomonas sp.
AC2) 		PF13419
(HAD_2) 		3 ASP A 174
PHE A   6
LEU A   9
 None
 0.59A 2zi9A-3smvA:
undetectable		 2zi9A-3smvA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3su8 PLEXIN-B1

(Homo sapiens) 		PF08337
(Plexin_cytopl) 		3 ASP X1934
PHE X1937
LEU X1941
 None
 0.63A 2zi9A-3su8X:
1.3		 2zi9A-3su8X:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 ASP A 560
PHE A 563
LEU A 567
 None
 0.21A 2zi9A-3txoA:
undetectable		 2zi9A-3txoA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3unn MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1

(Homo sapiens) 		PF00498
(FHA) 		3 ASP A  46
PHE A  47
LEU A  49
 None
 0.71A 2zi9A-3unnA:
undetectable		 2zi9A-3unnA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		3 ASP A  27
PHE A  24
LEU A  20
 None
 0.65A 2zi9A-3wzfA:
undetectable		 2zi9A-3wzfA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zil AAR187CP

(Eremothecium
gossypii) 		PF16997
(Wap1) 		3 ASP A 275
PHE A 272
LEU A 268
 None
 0.65A 2zi9A-3zilA:
undetectable		 2zi9A-3zilA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2p RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 ASP A 504
PHE A 505
LEU A 553
 None
 0.51A 2zi9A-4a2pA:
3.0		 2zi9A-4a2pA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE

(Homo sapiens) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		3 ASP A 236
PHE A 237
LEU A 242
 SAM  A1349 (-3.5A)
SAM  A1349 (-3.5A)
None
 0.45A 2zi9A-4a6eA:
undetectable		 2zi9A-4a6eA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00701
(DHDPS) 		3 ASP A 356
PHE A 359
LEU A 361
 None
 0.67A 2zi9A-4dppA:
undetectable		 2zi9A-4dppA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE

(Burkholderia
pseudomallei) 		PF00155
(Aminotran_1_2) 		3 ASP A  25
PHE A  22
LEU A  18
 None
 0.51A 2zi9A-4effA:
undetectable		 2zi9A-4effA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eh1 FLAVOHEMOPROTEIN

(Vibrio cholerae) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 ASP A 204
PHE A 205
LEU A 207
 None
 0.68A 2zi9A-4eh1A:
undetectable		 2zi9A-4eh1A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 ASP A 212
PHE A 216
LEU A 220
 ASP  A 212 ( 0.6A)
PHE  A 216 ( 1.3A)
LEU  A 220 ( 0.6A)
 0.69A 2zi9A-4flxA:
undetectable		 2zi9A-4flxA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		3 ASP A 572
PHE A 573
LEU A 611
 None
 0.29A 2zi9A-4gl2A:
2.5		 2zi9A-4gl2A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpn 6-PHOSPHO-BETA-D-GLU
COSIDASE

(Streptococcus
mutans) 		PF00232
(Glyco_hydro_1) 		3 ASP A 111
PHE A 114
LEU A 118
 None
 0.50A 2zi9A-4gpnA:
undetectable		 2zi9A-4gpnA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnn DIHYDRODIPICOLINATE
SYNTHASE

(Vitis vinifera) 		PF00701
(DHDPS) 		3 ASP A 318
PHE A 321
LEU A 323
 None
 0.54A 2zi9A-4hnnA:
undetectable		 2zi9A-4hnnA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5

(Sus scrofa) 		PF00271
(Helicase_C) 		3 ASP A 571
PHE A 572
LEU A 610
 None
 0.58A 2zi9A-4i1sA:
2.5		 2zi9A-4i1sA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixj FIMBRIAL PROTEIN
(PILIN)

(Clostridioides
difficile) 		no annotation 3 ASP A 138
PHE A 135
LEU A 131
 None
 0.66A 2zi9A-4ixjA:
undetectable		 2zi9A-4ixjA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1s POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		3 ASP A 306
PHE A 307
LEU A 309
 None
 0.74A 2zi9A-4j1sA:
2.4		 2zi9A-4j1sA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ki3 OUTER-MEMBRANE
LIPOPROTEIN CARRIER
PROTEIN

(Yersinia pestis) 		PF03548
(LolA) 		3 ASP A 133
PHE A 134
LEU A 136
 None
 0.64A 2zi9A-4ki3A:
undetectable		 2zi9A-4ki3A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhs UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF14606
(Lipase_GDSL_3)
PF14607
(GxDLY) 		3 ASP A 340
PHE A 343
LEU A 347
 None
 0.32A 2zi9A-4lhsA:
2.8		 2zi9A-4lhsA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1

(Saccharomyces
cerevisiae) 		PF02112
(PDEase_II) 		3 ASP A  39
PHE A  23
LEU A  25
 None
 0.61A 2zi9A-4ojxA:
undetectable		 2zi9A-4ojxA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlq BENZOATE-COENZYME A
LIGASE

(Rhodopseudomonas
palustris) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ASP A 254
PHE A 257
LEU A 261
 None
 0.48A 2zi9A-4rlqA:
undetectable		 2zi9A-4rlqA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, HEAVY CHAIN
SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		3 ASP D  99
PHE D 111
LEU E 186
 None
 0.72A 2zi9A-4v1dD:
undetectable		 2zi9A-4v1dD:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB

(Burkholderia
cenocepacia) 		PF00155
(Aminotran_1_2) 		3 ASP A  23
PHE A  20
LEU A  16
 None
 0.65A 2zi9A-4wd2A:
undetectable		 2zi9A-4wd2A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE

(Bacillus
licheniformis) 		PF01019
(G_glu_transpept) 		3 ASP A 303
PHE A 304
LEU A 306
 None
 0.73A 2zi9A-4y23A:
undetectable		 2zi9A-4y23A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF12862
(ANAPC5) 		3 ASP O 165
PHE O 162
LEU O 158
 None
 0.36A 2zi9A-5a31O:
undetectable		 2zi9A-5a31O:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq0 CARBOXYPEPTIDASE D

(Homo sapiens) 		PF13620
(CarboxypepD_reg) 		3 ASP A 456
PHE A 457
LEU A 459
 None
 0.68A 2zi9A-5aq0A:
undetectable		 2zi9A-5aq0A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b39 KILLER CELL
IMMUNOGLOBULIN-LIKE
RECEPTOR 3DL1

(Homo sapiens) 		PF00047
(ig) 		3 ASP G 258
PHE G 259
LEU G 261
 None
 0.61A 2zi9A-5b39G:
undetectable		 2zi9A-5b39G:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bug PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
3-PHOSPHATASE AND
DUAL-SPECIFICITY
PROTEIN PHOSPHATASE
PTEN

(Homo sapiens) 		PF00782
(DSPc)
PF10409
(PTEN_C2) 		3 ASP A 107
PHE A 104
LEU A 100
 None
 0.50A 2zi9A-5bugA:
undetectable		 2zi9A-5bugA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjb OSTEOCLAST-ASSOCIATE
D
IMMUNOGLOBULIN-LIKE
RECEPTOR

(Homo sapiens) 		PF13895
(Ig_2) 		3 ASP A 185
PHE A 186
LEU A 188
 None
 0.69A 2zi9A-5cjbA:
undetectable		 2zi9A-5cjbA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doz JAMJ

(Lyngbya
majuscula) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		3 ASP A 281
PHE A 278
LEU A 274
 None
None
NDP  A 502 (-3.9A)
 0.69A 2zi9A-5dozA:
undetectable		 2zi9A-5dozA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0o COHESIN SUBUNIT
PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P

(Lachancea
thermotolerans) 		no annotation 3 ASP A 326
PHE A 330
LEU A 322
 None
 0.72A 2zi9A-5f0oA:
undetectable		 2zi9A-5f0oA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsh CSM6

(Thermus
thermophilus) 		PF09670
(Cas_Cas02710) 		3 ASP A 195
PHE A 198
LEU A 202
 NI  A1467 (-2.2A)
None
None
 0.31A 2zi9A-5fshA:
undetectable		 2zi9A-5fshA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxe EUGENOL OXIDASE

(Rhodococcus
jostii) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		3 ASP A 216
PHE A 219
LEU A 162
 GOL  A1529 ( 4.4A)
None
FAD  A 600 (-4.3A)
 0.69A 2zi9A-5fxeA:
undetectable		 2zi9A-5fxeA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2c GATS-LIKE PROTEIN 3

(Homo sapiens) 		PF13840
(ACT_7) 		3 ASP A 121
PHE A 122
LEU A 124
 None
 0.65A 2zi9A-5i2cA:
undetectable		 2zi9A-5i2cA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irc RHO
GTPASE-ACTIVATING
PROTEIN 35

(Rattus
norvegicus) 		PF00620
(RhoGAP) 		3 ASP A1302
PHE A1299
LEU A1295
 None
 0.56A 2zi9A-5ircA:
undetectable		 2zi9A-5ircA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Schistosoma
mansoni) 		PF01048
(PNP_UDP_1) 		3 ASP A 130
PHE A 131
LEU A 133
 None
 0.68A 2zi9A-5ko5A:
undetectable		 2zi9A-5ko5A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lbj SMALL TOXIC
POLYPEPTIDE LDRD

(Escherichia
coli) 		PF13940
(Ldr_toxin) 		3 ASP A  13
PHE A  10
LEU A   6
 None
 0.67A 2zi9A-5lbjA:
undetectable		 2zi9A-5lbjA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsp HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF01437
(PSI)
PF01833
(TIG) 		3 ASP A 587
PHE A 588
LEU A 598
 None
 0.59A 2zi9A-5lspA:
undetectable		 2zi9A-5lspA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lz6 GOLGI RESIDENT
PROTEIN GCP60

(Homo sapiens) 		PF13897
(GOLD_2) 		3 ASP A 477
PHE A 433
LEU A 505
 None
 0.63A 2zi9A-5lz6A:
undetectable		 2zi9A-5lz6A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nhq AGNOPROTEIN

(Human
polyomavirus 2) 		PF01736
(Polyoma_agno) 		3 ASP A  44
PHE A  39
LEU A  36
 None
 0.59A 2zi9A-5nhqA:
undetectable		 2zi9A-5nhqA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME

(Arabidopsis
thaliana) 		no annotation 3 ASP A 141
PHE A 144
LEU A 148
 None
 0.34A 2zi9A-5nijA:
undetectable		 2zi9A-5nijA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkm PROTEIN SMG-9

(Caenorhabditis
elegans) 		no annotation 3 ASP D 325
PHE D 326
LEU D 227
 None
 0.65A 2zi9A-5nkmD:
3.0		 2zi9A-5nkmD:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 ASP A2372
PHE A2375
LEU A2379
 None
 0.21A 2zi9A-5nugA:
undetectable		 2zi9A-5nugA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obt VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME

(Arabidopsis
thaliana) 		no annotation 3 ASP A 141
PHE A 144
LEU A 148
 None
 0.38A 2zi9A-5obtA:
undetectable		 2zi9A-5obtA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovy PUTATIVE
TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Mycobacteroides
abscessus) 		no annotation 3 ASP B 155
PHE B 158
LEU B 162
 None
 0.65A 2zi9A-5ovyB:
undetectable		 2zi9A-5ovyB:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t7d PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF13420
(Acetyltransf_4) 		3 ASP A 167
PHE A 168
LEU A 170
 None
 0.74A 2zi9A-5t7dA:
undetectable		 2zi9A-5t7dA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td3 CATECHOL
1,2-DIOXYGENASE

(Burkholderia
vietnamiensis) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		3 ASP A 298
PHE A 299
LEU A 301
 None
 0.65A 2zi9A-5td3A:
undetectable		 2zi9A-5td3A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN

(Candida
albicans) 		PF00071
(Ras) 		3 ASP A 166
PHE A 169
LEU A 173
 None
 0.43A 2zi9A-5ub8A:
4.9		 2zi9A-5ub8A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui3 DIHYDRODIPICOLINATE
SYNTHASE

(Chlamydomonas
reinhardtii) 		no annotation 3 ASP D 315
PHE D 318
LEU D 320
 None
 0.69A 2zi9A-5ui3D:
undetectable		 2zi9A-5ui3D:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7

(Homo sapiens) 		PF00400
(WD40)
PF12937
(F-box-like) 		3 ASP B2550
PHE B2549
LEU B2547
 None
 0.60A 2zi9A-5v4bB:
undetectable		 2zi9A-5v4bB:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yma PUTATIVE RRNA
PROCESSING PROTEIN

(Chaetomium
thermophilum) 		no annotation 3 ASP A 149
PHE A 119
LEU A 123
 None
 0.66A 2zi9A-5ymaA:
undetectable		 2zi9A-5ymaA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk5 UBIQUITIN LIGASE CBL

(Salpingoeca
rosetta) 		no annotation 3 ASP A  27
PHE A  29
LEU A 100
 None
 0.69A 2zi9A-6bk5A:
undetectable		 2zi9A-6bk5A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ek2 SINGLE CHAIN FV
FRAGMENT

(Mus musculus) 		no annotation 3 ASP H 268
PHE H 276
LEU H 384
 None
 0.73A 2zi9A-6ek2H:
undetectable		 2zi9A-6ek2H:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhm -

(-) 		no annotation 3 ASP A 112
PHE A 113
LEU A 115
 None
 0.62A 2zi9A-6fhmA:
undetectable		 2zi9A-6fhmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PSAM

(Cyanidioschyzon
merolae) 		no annotation 3 ASP O 118
PHE O 121
LEU O 125
 None
None
CLA  O1602 (-3.9A)
 0.30A 2zi9A-6fosO:
undetectable		 2zi9A-6fosO:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ftx -

(-) 		no annotation 3 ASP W 764
PHE W 767
LEU W 715
 None
 0.64A 2zi9A-6ftxW:
undetectable		 2zi9A-6ftxW:
undetectable