SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZI9_A_CL9A401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rty YVQK PROTEIN

(Bacillus
subtilis) 		PF01923
(Cob_adeno_trans) 		5 GLU A 103
TYR A 159
ARG A 170
ARG A  96
GLU A  59
 None
 1.10A 2zi9A-1rtyA:
1.4		 2zi9A-1rtyA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vtk THYMIDINE KINASE

(Human
alphaherpesvirus
1) 		PF00693
(Herpes_TK) 		5 GLU A  83
TRP A  88
TYR A 101
GLN A 125
GLU A 225
 TMP  A 500 (-2.7A)
None
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 (-3.5A)
 1.11A 2zi9A-1vtkA:
15.3		 2zi9A-1vtkA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vtk THYMIDINE KINASE

(Human
alphaherpesvirus
1) 		PF00693
(Herpes_TK) 		5 GLU A  83
TYR A 101
GLN A 125
ARG A 163
GLU A 225
 TMP  A 500 (-2.7A)
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 (-3.3A)
TMP  A 500 (-3.5A)
 1.19A 2zi9A-1vtkA:
15.3		 2zi9A-1vtkA:
20.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a30 DEOXYCYTIDINE KINASE

(Homo sapiens) 		PF01712
(dNK) 		5 ILE A  30
GLU A  53
ARG A 104
ARG A 128
TYR A  86
 DCZ  A 302 ( 4.3A)
DCZ  A 302 (-3.0A)
None
DCZ  A 302 (-4.1A)
DCZ  A 302 (-4.6A)
 1.47A 2zi9A-2a30A:
34.6		 2zi9A-2a30A:
92.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a30 DEOXYCYTIDINE KINASE

(Homo sapiens) 		PF01712
(dNK) 		8 ILE A  30
GLU A  53
GLN A  97
ARG A 104
ARG A 128
ARG A 192
GLU A 197
TYR A 204
 DCZ  A 302 ( 4.3A)
DCZ  A 302 (-3.0A)
DCZ  A 302 (-3.2A)
None
DCZ  A 302 (-4.1A)
DCZ  A 302 ( 4.9A)
DCZ  A 302 (-3.5A)
None
 1.23A 2zi9A-2a30A:
34.6		 2zi9A-2a30A:
92.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a30 DEOXYCYTIDINE KINASE

(Homo sapiens) 		PF01712
(dNK) 		12 ILE A  30
GLU A  53
TRP A  58
MET A  85
TYR A  86
PHE A  96
GLN A  97
ARG A 104
ARG A 128
ARG A 194
GLU A 197
TYR A 204
 DCZ  A 302 ( 4.3A)
DCZ  A 302 (-3.0A)
None
DCZ  A 302 ( 4.3A)
DCZ  A 302 (-4.6A)
DCZ  A 302 (-4.6A)
DCZ  A 302 (-3.2A)
None
DCZ  A 302 (-4.1A)
DCZ  A 302 ( 4.8A)
DCZ  A 302 (-3.5A)
None
 0.75A 2zi9A-2a30A:
34.6		 2zi9A-2a30A:
92.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ah6 BH1595, UNKNOWN
CONSERVED PROTEIN

(Bacillus
halodurans) 		PF01923
(Cob_adeno_trans) 		6 ILE A  55
GLU A 104
TYR A 160
ARG A 171
ARG A  97
GLU A  58
 None
 1.39A 2zi9A-2ah6A:
1.5		 2zi9A-2ah6A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jaq DEOXYGUANOSINE
KINASE

(Mycoplasma
mycoides) 		PF01712
(dNK) 		5 GLN A  54
ARG A  61
ARG A  78
ARG A 145
TYR A 157
 DCP  A1202 (-2.9A)
None
DCP  A1202 (-2.8A)
DCP  A1202 (-2.8A)
None
 1.33A 2zi9A-2jaqA:
21.9		 2zi9A-2jaqA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jaq DEOXYGUANOSINE
KINASE

(Mycoplasma
mycoides) 		PF01712
(dNK) 		7 TYR A  43
GLN A  54
ARG A  61
ARG A  78
ARG A 147
GLU A 150
TYR A 157
 None
DCP  A1202 (-2.9A)
None
DCP  A1202 (-2.8A)
DCP  A1202 (-2.8A)
DCP  A1202 (-3.5A)
None
 0.77A 2zi9A-2jaqA:
21.9		 2zi9A-2jaqA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcs DEOXYNUCLEOSIDE
KINASE

(Drosophila
melanogaster) 		PF01712
(dNK) 		9 ILE A  29
TRP A  57
MET A  69
TYR A  70
PHE A  80
GLN A  81
ARG A 169
GLU A 172
TYR A 179
 TTP  A1210 (-3.9A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.3A)
TTP  A1210 (-3.6A)
None
 0.71A 2zi9A-2jcsA:
26.2		 2zi9A-2jcsA:
29.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcs DEOXYNUCLEOSIDE
KINASE

(Drosophila
melanogaster) 		PF01712
(dNK) 		6 ILE A  29
TRP A  57
PHE A  80
GLN A  81
ARG A 105
TYR A 179
 TTP  A1210 (-3.9A)
None
TTP  A1210 (-4.2A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
None
 0.97A 2zi9A-2jcsA:
26.2		 2zi9A-2jcsA:
29.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		5 GLU A  70
TRP A  75
MET A  99
PHE A 110
GLN A 111
 None
None
DTP  A 301 ( 3.9A)
DTP  A 301 (-4.2A)
DTP  A 301 (-2.9A)
 1.02A 2zi9A-2ocpA:
32.0		 2zi9A-2ocpA:
44.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		5 ILE A  47
ARG A 142
ARG A 206
GLU A 211
TYR A 218
 DTP  A 301 (-3.8A)
DTP  A 301 (-3.2A)
DTP  A 301 (-3.1A)
DTP  A 301 (-3.5A)
None
 1.33A 2zi9A-2ocpA:
32.0		 2zi9A-2ocpA:
44.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		10 ILE A  47
TRP A  75
MET A  99
TYR A 100
PHE A 110
GLN A 111
ARG A 142
ARG A 208
GLU A 211
TYR A 218
 DTP  A 301 (-3.8A)
None
DTP  A 301 ( 3.9A)
DTP  A 301 (-4.5A)
DTP  A 301 (-4.2A)
DTP  A 301 (-2.9A)
DTP  A 301 (-3.2A)
DTP  A 301 (-3.4A)
DTP  A 301 (-3.5A)
None
 0.58A 2zi9A-2ocpA:
32.0		 2zi9A-2ocpA:
44.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		9 ILE A  47
TRP A  75
TYR A 100
PHE A 110
ARG A 118
ARG A 142
ARG A 208
GLU A 211
TYR A 218
 DTP  A 301 (-3.8A)
None
DTP  A 301 (-4.5A)
DTP  A 301 (-4.2A)
DTP  A 301 (-3.1A)
DTP  A 301 (-3.2A)
DTP  A 301 (-3.4A)
DTP  A 301 (-3.5A)
None
 0.81A 2zi9A-2ocpA:
32.0		 2zi9A-2ocpA:
44.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke5 HYPOTHETICAL
CYTOSOLIC PROTEIN

(Bacillus cereus) 		PF01923
(Cob_adeno_trans) 		5 ILE A  55
GLU A 102
TYR A 158
ARG A 169
GLU A  58
 None
 1.27A 2zi9A-3ke5A:
undetectable		 2zi9A-3ke5A:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		5 ILE A1245
PHE A1357
GLN A1366
ARG A1379
GLU A1264
 None
 1.44A 2zi9A-4iglA:
0.0		 2zi9A-4iglA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m99 ALPHA-AMYLASE

(Thermotoga
petrophila) 		PF00128
(Alpha-amylase) 		5 GLU B 253
MET B 275
TYR B 276
PHE B 300
ARG B 211
 K  B 605 ( 4.7A)
None
None
None
K  B 605 ( 4.8A)
 1.06A 2zi9A-5m99B:
0.0		 2zi9A-5m99B:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no8 BACCELL_00875

(Bacteroides
cellulosilyticus) 		no annotation 5 ILE A 492
GLU A 537
TYR A 613
PHE A 600
ARG A 445
 None
GOL  A 701 (-4.5A)
None
None
None
 1.21A 2zi9A-5no8A:
0.0		 2zi9A-5no8A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Homo sapiens) 		PF06212
(GRIM-19) 		5 ILE w  66
TYR w 118
GLN w 132
ARG w 161
TYR w 233
 None
 1.19A 2zi9A-5xtdw:
16.8		 2zi9A-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Homo sapiens) 		PF06212
(GRIM-19) 		5 ILE w  66
TYR w 118
GLN w 132
GLU w 226
TYR w 233
 None
 1.00A 2zi9A-5xtdw:
16.8		 2zi9A-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Homo sapiens) 		PF06212
(GRIM-19) 		5 TYR w 118
GLN w 132
ARG w 139
ARG w 161
TYR w 233
 None
 1.18A 2zi9A-5xtdw:
16.8		 2zi9A-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Homo sapiens) 		PF06212
(GRIM-19) 		5 TYR w 118
GLN w 132
ARG w 139
GLU w 226
TYR w 233
 None
 1.08A 2zi9A-5xtdw:
16.8		 2zi9A-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Mus musculus) 		no annotation 6 ILE O  31
GLU O  53
TYR O  83
ARG O 104
ARG O 126
GLU O 191
 ADP  O 401 (-4.0A)
ADP  O 401 ( 4.7A)
ADP  O 401 (-4.9A)
ADP  O 401 (-4.5A)
ADP  O 401 ( 4.3A)
ADP  O 401 (-3.2A)
 0.96A 2zi9A-6g2jO:
undetectable		 2zi9A-6g2jO:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Mus musculus) 		no annotation 6 ILE O  31
GLU O  53
TYR O  83
ARG O 126
GLU O 191
TYR O 198
 ADP  O 401 (-4.0A)
ADP  O 401 ( 4.7A)
ADP  O 401 (-4.9A)
ADP  O 401 ( 4.3A)
ADP  O 401 (-3.2A)
None
 0.89A 2zi9A-6g2jO:
undetectable		 2zi9A-6g2jO:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Mus musculus) 		no annotation 6 ILE O  31
GLU O  53
TYR O  83
GLN O  97
GLU O 191
TYR O 198
 ADP  O 401 (-4.0A)
ADP  O 401 ( 4.7A)
ADP  O 401 (-4.9A)
ADP  O 401 (-3.5A)
ADP  O 401 (-3.2A)
None
 0.94A 2zi9A-6g2jO:
undetectable		 2zi9A-6g2jO:
15.05