SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZGW_A_ADNA1301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1awb MYO-INOSITOL
MONOPHOSPHATASE

(Homo sapiens) 		PF00459
(Inositol_P) 		4 GLU A 260
ALA A 210
ASN A 255
ALA A 253
 None
 1.08A 2zgwA-1awbA:
0.0		 2zgwA-1awbA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bue PROTEIN
(IMIPENEM-HYDROLYSIN
G BETA-LACTAMASE)

(Enterobacter
cloacae) 		PF13354
(Beta-lactamase2) 		4 ARG A  65
GLU A  64
ALA A 185
ALA A 184
 None
 0.94A 2zgwA-1bueA:
undetectable		 2zgwA-1bueA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dw3 CYTOCHROME C

(Rhodobacter
sphaeroides) 		PF09086
(DUF1924) 		4 ARG A  24
GLU A 101
ALA A  18
ALA A  16
 None
 0.89A 2zgwA-1dw3A:
undetectable		 2zgwA-1dw3A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE

(Grifola
frondosa) 		PF14521
(Aspzincin_M35) 		4 GLU A 157
ALA A 137
ASN A 152
ALA A 138
 None
 1.11A 2zgwA-1ge7A:
0.0		 2zgwA-1ge7A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Escherichia
coli) 		PF02668
(TauD) 		4 GLU A 118
ALA A 115
ASN A 243
ALA A 116
 None
 1.10A 2zgwA-1gy9A:
0.0		 2zgwA-1gy9A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imv PIGMENT
EPITHELIUM-DERIVED
FACTOR

(Homo sapiens) 		PF00079
(Serpin) 		4 GLU A 104
ALA A 385
ASN A  32
ALA A  35
 None
 1.09A 2zgwA-1imvA:
undetectable		 2zgwA-1imvA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jif BLEOMYCIN-BINDING
PROTEIN

(Streptomyces
verticillus) 		no annotation 4 ALA A  13
ASN A 114
PRO A 111
ALA A 112
 None
 1.14A 2zgwA-1jifA:
0.7		 2zgwA-1jifA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jnf SEROTRANSFERRIN

(Oryctolagus
cuniculus) 		PF00405
(Transferrin) 		4 ALA A 583
ASN A 581
PRO A 421
ALA A 409
 None
 1.10A 2zgwA-1jnfA:
0.0		 2zgwA-1jnfA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		4 ARG A 562
GLU A 492
ALA A 485
ALA A 497
 None
 1.07A 2zgwA-1kehA:
0.0		 2zgwA-1kehA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krm ADENOSINE DEAMINASE

(Bos taurus) 		PF00962
(A_deaminase) 		4 GLU A  10
ALA A 327
ASN A 323
ALA A 326
 None
 0.93A 2zgwA-1krmA:
undetectable		 2zgwA-1krmA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kz1 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Schizosaccharomyces
pombe) 		PF00885
(DMRL_synthase) 		4 GLU A  33
ALA A 130
PRO A  34
ALA A 134
 None
 1.12A 2zgwA-1kz1A:
undetectable		 2zgwA-1kz1A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lr1 DNA-BINDING PROTEIN
H-NS

(Escherichia
coli) 		no annotation 4 ARG A  40
GLU A  41
ALA A  47
ALA A  46
 None
 1.11A 2zgwA-1lr1A:
undetectable		 2zgwA-1lr1A:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mky PROBABLE GTP-BINDING
PROTEIN ENGA

(Thermotoga
maritima) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		4 GLU A 141
ALA A 120
PRO A 142
ALA A 117
 None
 1.10A 2zgwA-1mkyA:
undetectable		 2zgwA-1mkyA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n4o L2 BETA-LACTAMASE

(Stenotrophomonas
maltophilia) 		PF13354
(Beta-lactamase2) 		4 ARG A  65
GLU A  64
ALA A 185
ALA A 184
 None
 0.93A 2zgwA-1n4oA:
undetectable		 2zgwA-1n4oA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npb FOSFOMYCIN-RESISTANC
E PROTEIN

(Serratia
marcescens) 		PF00903
(Glyoxalase) 		4 ARG A 122
GLU A  98
ASN A  95
ALA A 100
 SO4  A 403 ( 3.4A)
None
None
None
 1.13A 2zgwA-1npbA:
undetectable		 2zgwA-1npbA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogp SULFITE OXIDASE

(Arabidopsis
thaliana) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 GLU A 319
ALA A  94
ASN A 124
ALA A 335
 None
 1.14A 2zgwA-1ogpA:
undetectable		 2zgwA-1ogpA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohf NUDAURELIA CAPENSIS
OMEGA VIRUS CAPSID
PROTEIN

(Nudaurelia
capensis omega
virus) 		PF03566
(Peptidase_A21) 		4 ARG A 128
GLU A 129
ALA A 125
PRO A 220
 None
 1.08A 2zgwA-1ohfA:
undetectable		 2zgwA-1ohfA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcq CATABOLIC ALANINE
RACEMASE DADX

(Pseudomonas
aeruginosa) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ARG A 169
GLU A 171
ALA A 176
ALA A 175
 None
 1.14A 2zgwA-1rcqA:
undetectable		 2zgwA-1rcqA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv SEROTRANSFERRIN,
C-LOBE

(Homo sapiens) 		PF00405
(Transferrin) 		4 ALA E 583
ASN E 581
PRO E 421
ALA E 409
 None
 1.10A 2zgwA-1suvE:
undetectable		 2zgwA-1suvE:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE

(Pyrococcus
horikoshii) 		PF04587
(ADP_PFK_GK) 		4 GLU A 282
ALA A  33
ASN A  35
ALA A 120
 None
None
SO4  A1003 (-3.8A)
None
 1.04A 2zgwA-1u2xA:
4.6		 2zgwA-1u2xA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ued P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 ARG A 326
GLU A 284
ASN A 264
ALA A 260
 None
 0.99A 2zgwA-1uedA:
undetectable		 2zgwA-1uedA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uio ADENOSINE DEAMINASE

(Mus musculus) 		PF00962
(A_deaminase) 		4 GLU A  13
ALA A 330
ASN A 326
ALA A 329
 None
 0.99A 2zgwA-1uioA:
undetectable		 2zgwA-1uioA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzh DESULFOFERRODOXIN

(Desulfarculus
baarsii) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		4 GLU A 114
ASN A  40
PRO A  51
ALA A 124
 None
 1.10A 2zgwA-1vzhA:
undetectable		 2zgwA-1vzhA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr6 GLUCOOLIGOSACCHARIDE
OXIDASE

(Sarocladium
strictum) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 GLU A 461
ALA A 474
PRO A 460
ALA A 456
 None
 1.11A 2zgwA-1zr6A:
undetectable		 2zgwA-1zr6A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME C1

(Rhodobacter
capsulatus) 		PF02167
(Cytochrom_C1) 		4 GLU D 129
ALA D 217
PRO D 128
ALA D 104
 None
 1.14A 2zgwA-1zrtD:
undetectable		 2zgwA-1zrtD:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzm PUTATIVE
DEOXYRIBONUCLEASE
YJJV

(Escherichia
coli) 		PF01026
(TatD_DNase) 		4 GLU A  97
ALA A  94
PRO A  39
ALA A  62
 ZN  A 401 ( 2.3A)
None
None
None
 1.08A 2zgwA-1zzmA:
undetectable		 2zgwA-1zzmA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Sulfolobus
solfataricus) 		PF00218
(IGPS) 		4 GLU A  39
ALA A 229
ASN A  41
ALA A  47
 None
 1.08A 2zgwA-2c3zA:
undetectable		 2zgwA-2c3zA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE

(Thermus
thermophilus) 		PF00698
(Acyl_transf_1) 		4 GLU A 231
ALA A  95
PRO A 217
ALA A  99
 None
 1.13A 2zgwA-2cuyA:
undetectable		 2zgwA-2cuyA:
24.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE

(Pyrococcus
horikoshii) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		6 TRP A  53
GLU A  54
ALA A 111
ASN A 131
PRO A 137
ALA A 140
 BT5  A1301 (-3.8A)
None
BT5  A1301 ( 3.8A)
BT5  A1301 (-3.0A)
BT5  A1301 (-4.6A)
BT5  A1301 (-3.4A)
 0.10A 2zgwA-2djzA:
43.5		 2zgwA-2djzA:
99.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2du9 PREDICTED
TRANSCRIPTIONAL
REGULATORS

(Corynebacterium
glutamicum) 		PF00392
(GntR) 		4 ALA A  36
ASN A  32
PRO A  42
ALA A  35
 None
 1.07A 2zgwA-2du9A:
undetectable		 2zgwA-2du9A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV

(Stenotrophomonas
maltophilia) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 TRP A 639
ASN A 611
PRO A 527
ALA A 528
 None
 1.05A 2zgwA-2ecfA:
undetectable		 2zgwA-2ecfA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG

(Thermus
thermophilus) 		PF05690
(ThiG) 		4 GLU A  30
ALA A  35
PRO A 217
ALA A 220
 None
 1.11A 2zgwA-2htmA:
undetectable		 2zgwA-2htmA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l4o CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF16555
(GramPos_pilinD1) 		4 GLU A  55
ALA A  44
PRO A  70
ALA A  73
 None
 0.75A 2zgwA-2l4oA:
undetectable		 2zgwA-2l4oA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pan GLYOXYLATE
CARBOLIGASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ARG A  63
ALA A  92
PRO A 420
ALA A 418
 None
 1.09A 2zgwA-2panA:
undetectable		 2zgwA-2panA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1v DJ-1

(Homo sapiens) 		PF01965
(DJ-1_PfpI) 		4 GLU A  15
ALA A 129
ASN A  76
ALA A 107
 None
 0.94A 2zgwA-2r1vA:
undetectable		 2zgwA-2r1vA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ws2 GLUTATHIONE
S-TRANSFERASE

(Haemonchus
contortus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ARG A  69
GLU A  85
ALA A  92
ALA A 156
 None
 0.94A 2zgwA-2ws2A:
undetectable		 2zgwA-2ws2A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF05424
(Duffy_binding)
PF15447
(NTS) 		4 ARG A 134
GLU A 322
ALA A 131
ALA A 111
 None
 1.12A 2zgwA-2xu0A:
undetectable		 2zgwA-2xu0A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anp TRANSCRIPTIONAL
REPRESSOR, TETR
FAMILY

(Thermus
thermophilus) 		no annotation 4 ARG C  16
GLU C  20
ALA C  39
ALA C  38
 None
 0.98A 2zgwA-3anpC:
undetectable		 2zgwA-3anpC:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b70 ENOYL REDUCTASE

(Aspergillus
terreus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ARG A  89
GLU A  44
ALA A 130
ALA A 131
 None
 1.05A 2zgwA-3b70A:
undetectable		 2zgwA-3b70A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf8 ESTERASE YBFF

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		5 TRP A 188
GLU A 189
ALA A  94
PRO A  65
ALA A  68
 None
 1.32A 2zgwA-3bf8A:
undetectable		 2zgwA-3bf8A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cne PUTATIVE PROTEASE I

(Bacteroides
thetaiotaomicron) 		PF01965
(DJ-1_PfpI) 		4 GLU A  42
ALA A   9
ASN A  11
ALA A  36
 None
 0.95A 2zgwA-3cneA:
undetectable		 2zgwA-3cneA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		4 ARG X 140
ALA X  62
ASN X  66
ALA X  12
 None
FE  X 326 ( 4.6A)
None
None
 1.13A 2zgwA-3e13X:
undetectable		 2zgwA-3e13X:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epc PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		4 GLU 2  55
ALA 2  59
ASN 2  95
ALA 2  60
 None
 1.07A 2zgwA-3epc2:
undetectable		 2zgwA-3epc2:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epf PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		4 GLU 2  55
ALA 2  59
ASN 2  95
ALA 2  60
 None
 0.97A 2zgwA-3epf2:
undetectable		 2zgwA-3epf2:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg8 UNCHARACTERIZED
PROTEIN RHA05790

(Rhodococcus
jostii) 		PF08448
(PAS_4) 		4 ARG A 120
GLU A 204
ALA A 208
ALA A 207
 None
 1.12A 2zgwA-3fg8A:
undetectable		 2zgwA-3fg8A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g27 82 PROPHAGE-DERIVED
UNCHARACTERIZED
PROTEIN YBCO

(Escherichia
coli) 		PF07102
(DUF1364) 		4 ARG A  64
GLU A  60
ALA A  31
ALA A  53
 None
 1.00A 2zgwA-3g27A:
undetectable		 2zgwA-3g27A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3l PUTATIVE
UNCHARACTERIZED
MEMBRANE-ASSOCIATED
PROTEIN

(Bacteroides
fragilis) 		PF12985
(DUF3869) 		4 GLU A  60
ALA A  55
ASN A 275
ALA A 122
 None
None
GOL  A  10 (-4.3A)
None
 1.14A 2zgwA-3g3lA:
undetectable		 2zgwA-3g3lA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyk 27KDA OUTER MEMBRANE
PROTEIN

(Ruegeria
pomeroyi) 		PF13462
(Thioredoxin_4) 		4 ARG A  70
GLU A  57
ALA A 125
ASN A  10
 None
 1.11A 2zgwA-3gykA:
undetectable		 2zgwA-3gykA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h75 PERIPLASMIC
SUGAR-BINDING DOMAIN
PROTEIN

(Pseudomonas
protegens) 		PF13407
(Peripla_BP_4) 		4 ARG A  92
GLU A 222
ALA A 195
ALA A 196
 SO4  A 400 (-2.9A)
None
SO4  A 400 (-3.4A)
None
 1.01A 2zgwA-3h75A:
undetectable		 2zgwA-3h75A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		4 ARG A 411
GLU A 410
ALA A 307
ALA A 305
 None
 1.11A 2zgwA-3i04A:
undetectable		 2zgwA-3i04A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbe NANOBODY VHH PVSS8A

(Camelus
dromedarius) 		PF07686
(V-set) 		4 ARG 7  45
GLU 7  46
ALA 7  97
ALA 7  35
 None
 1.08A 2zgwA-3jbe7:
undetectable		 2zgwA-3jbe7:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11

(Homo sapiens) 		PF00621
(RhoGEF) 		4 GLU A 824
ALA A 830
ASN A 781
ALA A 829
 None
 1.14A 2zgwA-3kz1A:
1.6		 2zgwA-3kz1A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 GLU A 427
ALA A 147
PRO A 139
ALA A 143
 None
 1.12A 2zgwA-3lk6A:
undetectable		 2zgwA-3lk6A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwp 6-PHOSPHOGLUCONOLACT
ONASE

(Shewanella
baltica) 		PF01182
(Glucosamine_iso) 		5 TRP A  74
GLU A  72
ALA A 115
ASN A 106
ALA A 118
 None
 1.22A 2zgwA-3nwpA:
undetectable		 2zgwA-3nwpA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9b CYTOCHROME P450
164A2

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		4 GLU A 389
ALA A 284
PRO A 388
ALA A 283
 None
 0.84A 2zgwA-3r9bA:
undetectable		 2zgwA-3r9bA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrl SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE SUBUNIT
A
SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE SUBUNIT
B

(Helicobacter
pylori) 		PF01144
(CoA_trans) 		4 ARG B  89
ALA A 104
ASN A 106
PRO A  99
 None
 1.10A 2zgwA-3rrlB:
undetectable		 2zgwA-3rrlB:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6o POLYSACCHARIDE
DEACETYLASE FAMILY
PROTEIN

(Burkholderia
pseudomallei) 		PF01522
(Polysacc_deac_1) 		4 ALA A  64
ASN A  43
PRO A  50
ALA A  51
 None
 0.87A 2zgwA-3s6oA:
undetectable		 2zgwA-3s6oA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sag EXOSOME COMPONENT 10

(Homo sapiens) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		4 ARG A 452
ALA A 270
PRO A 267
ALA A 268
 ARG  A 452 ( 0.6A)
ALA  A 270 ( 0.0A)
PRO  A 267 ( 1.1A)
ALA  A 268 ( 0.0A)
 1.07A 2zgwA-3sagA:
undetectable		 2zgwA-3sagA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skp SEROTRANSFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		4 ARG A 644
ALA A 409
PRO A 406
ALA A 586
 SO4  A 682 (-3.8A)
None
None
None
 0.94A 2zgwA-3skpA:
undetectable		 2zgwA-3skpA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tvi ASPARTOKINASE

(Clostridium
acetobutylicum) 		PF00696
(AA_kinase)
PF01842
(ACT) 		4 ARG A 114
ALA A 135
PRO A 168
ALA A 134
 None
 0.95A 2zgwA-3tviA:
3.2		 2zgwA-3tviA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vis ESTERASE

(Thermobifida
alba) 		PF12740
(Chlorophyllase2) 		4 ALA A 245
ASN A 254
PRO A 250
ALA A 249
 None
 1.11A 2zgwA-3visA:
undetectable		 2zgwA-3visA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN

(Streptomyces
thermoviolaceus) 		PF01547
(SBP_bac_1) 		4 ARG A 346
ALA A  68
ASN A 337
ALA A  70
 None
 1.14A 2zgwA-3vxcA:
undetectable		 2zgwA-3vxcA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
ALPHA CHAIN

(Thermus
thermophilus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		4 ALA A 301
ASN A 290
PRO A 295
ALA A 298
 None
 0.97A 2zgwA-3w3aA:
undetectable		 2zgwA-3w3aA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4q BETA-LACTAMASE

(Burkholderia
multivorans) 		PF13354
(Beta-lactamase2) 		4 ARG A  65
GLU A  64
ALA A 185
ALA A 184
 None
 0.93A 2zgwA-3w4qA:
undetectable		 2zgwA-3w4qA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zc1 AFTRAX

(Archaeoglobus
fulgidus) 		PF01997
(Translin) 		4 ARG A   9
GLU A  11
ALA A  16
ALA A  15
 None
 1.08A 2zgwA-3zc1A:
undetectable		 2zgwA-3zc1A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdj ENCA BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		4 ARG A  65
GLU A  64
ALA A 185
ALA A 184
 None
 0.96A 2zgwA-3zdjA:
undetectable		 2zgwA-3zdjA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a29 ENGINEERED
RETRO-ALDOL ENZYME
RA95.0

(synthetic
construct) 		PF00218
(IGPS) 		4 GLU A  39
ALA A 229
ASN A  41
ALA A  47
 None
 0.94A 2zgwA-4a29A:
undetectable		 2zgwA-4a29A:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c75 BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		4 ARG A  65
GLU A  64
ALA A 185
ALA A 184
 None
 0.93A 2zgwA-4c75A:
undetectable		 2zgwA-4c75A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cg1 CUTINASE

(Thermobifida
fusca) 		PF12740
(Chlorophyllase2) 		4 ALA A 206
ASN A 215
PRO A 211
ALA A 210
 None
 1.08A 2zgwA-4cg1A:
undetectable		 2zgwA-4cg1A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1y PUTATIVE PROTEASE I

(Bacteroides
thetaiotaomicron) 		PF01965
(DJ-1_PfpI) 		4 GLU A  42
ALA A   9
ASN A  11
ALA A  36
 None
 0.88A 2zgwA-4d1yA:
undetectable		 2zgwA-4d1yA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewt PEPTIDASE,
M20/M25/M40 FAMILY

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 GLU A 282
ALA A 208
ASN A 206
ALA A 211
 None
None
PEG  A 403 (-3.9A)
None
 1.09A 2zgwA-4ewtA:
4.0		 2zgwA-4ewtA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hgz CCBJ

(Streptomyces
caelestis) 		PF13649
(Methyltransf_25) 		4 ARG A  55
ALA A  33
PRO A  59
ALA A  34
 None
 0.97A 2zgwA-4hgzA:
undetectable		 2zgwA-4hgzA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		4 ARG A  63
ALA A 210
ASN A 212
ALA A 181
 None
 1.01A 2zgwA-4i8qA:
undetectable		 2zgwA-4i8qA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irl MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NOVEL PROTEIN
SIMILAR TO
VERTEBRATE GUANYLATE
BINDING PROTEIN
FAMILY

(Danio rerio;
Escherichia
coli) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 GLU A 441
ALA A 339
ASN A 368
ALA A 372
 None
 1.10A 2zgwA-4irlA:
undetectable		 2zgwA-4irlA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4r LPS-ASSEMBLY PROTEIN
LPTD

(Salmonella
enterica) 		PF04453
(OstA_C) 		4 ARG A 576
GLU A 575
ALA A 572
ALA A 573
 None
 1.08A 2zgwA-4n4rA:
undetectable		 2zgwA-4n4rA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6d TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Desulfovibrio
salexigens) 		PF03480
(DctP) 		4 GLU A 109
ALA A 120
PRO A 234
ALA A 146
 None
 0.95A 2zgwA-4n6dA:
undetectable		 2zgwA-4n6dA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzs BETA-KETOTHIOLASE
BKTB

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ALA A 354
ASN A  56
PRO A  27
ALA A 117
 None
 1.05A 2zgwA-4nzsA:
undetectable		 2zgwA-4nzsA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmd UNCHARACTERIZED
PROTEIN

(Mycolicibacterium
smegmatis) 		no annotation 4 GLU A 163
ALA A 198
ASN A  95
ALA A 180
 None
 1.10A 2zgwA-4tmdA:
2.6		 2zgwA-4tmdA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei) 		PF00067
(p450) 		4 ARG A 326
GLU A 285
ASN A 265
ALA A 261
 None
 1.03A 2zgwA-4tpnA:
undetectable		 2zgwA-4tpnA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfi CUTINASE

(Saccharomonospora
viridis) 		PF03403
(PAF-AH_p_II) 		4 ALA A 252
ASN A 261
PRO A 257
ALA A 256
 None
 1.13A 2zgwA-4wfiA:
undetectable		 2zgwA-4wfiA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi5 P91

(metagenome) 		PF01738
(DLH) 		4 ARG A   4
GLU A  18
ALA A  58
ALA A  59
 None
 0.93A 2zgwA-4zi5A:
undetectable		 2zgwA-4zi5A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2

(Ascophyllum
nodosum) 		no annotation 4 TRP A 236
GLU A 546
ALA A 527
ALA A 452
 None
 0.79A 2zgwA-5aa6A:
0.4		 2zgwA-5aa6A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1y 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Aeropyrum
pernix) 		PF13561
(adh_short_C2) 		4 ARG A  25
GLU A  26
ALA A  18
ALA A 222
 None
 1.11A 2zgwA-5b1yA:
undetectable		 2zgwA-5b1yA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cj3 ZBM BINDING PROTEIN

(Streptomyces
flavoviridis) 		no annotation 4 ALA A  13
ASN A 114
PRO A 111
ALA A 112
 None
 1.14A 2zgwA-5cj3A:
undetectable		 2zgwA-5cj3A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csa ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00364
(Biotin_lipoyl)
PF08326
(ACC_central) 		4 TRP A 843
ALA A 911
PRO A 877
ALA A 878
 None
 0.95A 2zgwA-5csaA:
undetectable		 2zgwA-5csaA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		4 TRP A 843
ALA A 911
PRO A 877
ALA A 878
 None
 0.98A 2zgwA-5cslA:
undetectable		 2zgwA-5cslA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dd4 TRANSCRIPTIONAL
REGULATOR ARAR

(Bacteroides
thetaiotaomicron) 		PF00293
(NUDIX) 		4 ARG A 218
GLU A 149
ASN A 154
PRO A 150
 None
 1.14A 2zgwA-5dd4A:
undetectable		 2zgwA-5dd4A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjw VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		4 GLU F 414
ASN F 424
PRO F 416
ALA F 420
 None
 1.00A 2zgwA-5gjwF:
undetectable		 2zgwA-5gjwF:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl9 BETA-LACTAMASE

(Burkholderia
thailandensis) 		PF13354
(Beta-lactamase2) 		4 ARG A  65
GLU A  64
ALA A 185
ALA A 184
 None
 0.94A 2zgwA-5gl9A:
undetectable		 2zgwA-5gl9A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxd PROTEIN MPAA

(Escherichia
coli) 		PF00246
(Peptidase_M14) 		4 GLU A  18
ALA A  37
PRO A  33
ALA A  34
 None
 1.08A 2zgwA-5hxdA:
undetectable		 2zgwA-5hxdA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6e ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		4 TRP A 843
ALA A 911
PRO A 877
ALA A 878
 None
 0.99A 2zgwA-5i6eA:
undetectable		 2zgwA-5i6eA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic8 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 4 GLU A 174
ALA A 295
PRO A 175
ALA A 296
 None
 1.01A 2zgwA-5ic8A:
undetectable		 2zgwA-5ic8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5od2 BIFUNCTIONAL
ADP-SPECIFIC
GLUCOKINASE/PHOSPHOF
RUCTOKINASE

(Methanocaldococcus
jannaschii) 		no annotation 4 GLU A 272
ALA A  22
ASN A  24
ALA A 109
 None
 1.04A 2zgwA-5od2A:
3.8		 2zgwA-5od2A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tub SHARK TBC1D15
GTPASE-ACTIVATING
PROTEIN

(Squalimorphii) 		PF00566
(RabGAP-TBC) 		4 ARG A 333
GLU A 622
ALA A 627
ALA A 588
 None
 1.14A 2zgwA-5tubA:
undetectable		 2zgwA-5tubA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uto EDD DOMAIN PROTEIN,
DEGV FAMILY

(Staphylococcus
aureus) 		no annotation 4 ALA A 268
ASN A 167
PRO A  60
ALA A 269
 None
 0.98A 2zgwA-5utoA:
undetectable		 2zgwA-5utoA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Burkholderia
ambifaria) 		PF00905
(Transpeptidase) 		4 ARG A 514
ALA A 258
PRO A 537
ALA A 256
 None
 1.00A 2zgwA-5uy7A:
undetectable		 2zgwA-5uy7A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyl INNER TEGUMENT
PROTEIN

(Human
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		4 ARG A 553
GLU A 102
PRO A 101
ALA A 540
 None
 1.04A 2zgwA-5vylA:
undetectable		 2zgwA-5vylA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B

(Pyrococcus
abyssi) 		PF02475
(Met_10) 		4 GLU A 221
ALA A 191
PRO A 234
ALA A 209
 None
 1.09A 2zgwA-5yacA:
undetectable		 2zgwA-5yacA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6an5 ABC TRANSPORTER

(Aquifex
aeolicus) 		no annotation 4 GLU A  89
ALA A 151
ASN A 107
ALA A 155
 None
 1.03A 2zgwA-6an5A:
undetectable		 2zgwA-6an5A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE

(Methanosarcinales) 		no annotation 4 GLU A 282
ALA A  30
ASN A  32
ALA A 117
 None
 1.13A 2zgwA-6c8zA:
2.9		 2zgwA-6c8zA:
15.25