SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZE2_A_T27A556

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f20 NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		5 ILE A1362
VAL A1247
TYR A1347
PRO A1243
LEU A1339
 None
 1.25A 2ze2A-1f20A:
0.7		 2ze2A-1f20A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixk METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		5 ILE A  35
TYR A  16
PRO A 251
LEU A 249
TYR A 298
 None
 1.46A 2ze2A-1ixkA:
1.9		 2ze2A-1ixkA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8w PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Pyrococcus
furiosus) 		PF01470
(Peptidase_C15) 		5 ILE A 103
ASN A 143
TYR A 111
LEU A 148
TYR A 144
 None
 1.48A 2ze2A-1z8wA:
0.5		 2ze2A-1z8wA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmf RNA HELICASE

(Dengue virus) 		PF07652
(Flavi_DEAD) 		5 PRO A 593
ILE A 600
VAL A 441
TRP A 562
LEU A 542
 None
 1.27A 2ze2A-2bmfA:
0.3		 2ze2A-2bmfA:
21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 PRO A  95
PRO A 226
TRP A 229
LEU A 234
TYR A 318
 PC0  A 999 ( 4.9A)
None
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 1.24A 2ze2A-2hnzA:
35.3		 2ze2A-2hnzA:
98.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 PRO A  95
TYR A 181
TRP A 229
LEU A 234
TYR A 318
 PC0  A 999 ( 4.9A)
PC0  A 999 (-3.9A)
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.71A 2ze2A-2hnzA:
35.3		 2ze2A-2hnzA:
98.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 PRO A  95
VAL A 179
TYR A 181
TRP A 229
TYR A 318
 PC0  A 999 ( 4.9A)
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.3A)
 0.80A 2ze2A-2hnzA:
35.3		 2ze2A-2hnzA:
98.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 TYR A 181
TYR A 188
PRO A 225
LEU A 234
TYR A 318
 PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
None
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.81A 2ze2A-2hnzA:
35.3		 2ze2A-2hnzA:
98.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 VAL A 179
TYR A 181
TYR A 188
PRO A 225
TYR A 318
 PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
None
PC0  A 999 (-4.3A)
 0.86A 2ze2A-2hnzA:
35.3		 2ze2A-2hnzA:
98.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ism PUTATIVE
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF07995
(GSDH) 		5 ILE A  53
TYR A  93
PRO A  90
LEU A 110
TYR A  64
 None
 1.47A 2ze2A-2ismA:
0.5		 2ze2A-2ismA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kmt CCDB

(Aliivibrio
fischeri) 		PF01845
(CcdB) 		5 PRO A  56
ILE A  94
VAL A  37
TYR A  20
LEU A  87
 None
 1.35A 2ze2A-2kmtA:
0.0		 2ze2A-2kmtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5i RESPONSE
REGULATOR/SENSORY
BOX PROTEIN/GGDEF
DOMAIN PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF00072
(Response_reg) 		5 PRO A  49
ILE A   6
TYR A 100
LEU A 120
TYR A  28
 None
 1.08A 2ze2A-3h5iA:
0.0		 2ze2A-3h5iA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2q UNCHARACTERIZED
GST-LIKE PROTEIN
YIBF

(Escherichia
coli) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 PRO A  64
ASN A 152
VAL A  90
PRO A  77
LEU A  18
 GSH  A 301 (-4.7A)
None
None
None
None
 1.25A 2ze2A-3r2qA:
0.8		 2ze2A-3r2qA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsn 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Campylobacter
jejuni) 		PF04166
(PdxA) 		5 ASN A  12
TYR A 108
PRO A 132
LEU A  16
TYR A 340
 None
 1.34A 2ze2A-3tsnA:
1.5		 2ze2A-3tsnA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d72 GLYCOSIDE HYDROLASE

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		5 PRO A 433
ILE A 428
VAL A 475
TYR A 473
TYR A 584
 None
 1.39A 2ze2A-4d72A:
0.3		 2ze2A-4d72A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fus RTX TOXINS AND
RELATED CA2+-BINDING
PROTEIN

(Hahella
chejuensis) 		PF02011
(Glyco_hydro_48) 		5 PRO A 118
ILE A 116
TYR A 250
LEU A 182
TYR A  85
 None
 1.29A 2ze2A-4fusA:
undetectable		 2ze2A-4fusA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lqx TENA/THI-4
DOMAIN-CONTAINING
PROTEIN

(Sulfolobus
solfataricus) 		PF03070
(TENA_THI-4)
PF16293
(zf-C2H2_9) 		5 ILE A 223
ASN A  91
TYR A 218
LEU A  97
TYR A 229
 None
None
UNL  A 402 ( 4.7A)
None
None
 1.30A 2ze2A-4lqxA:
undetectable		 2ze2A-4lqxA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npa PUTATIVE
UNCHARACTERIZED
PROTEIN

(Vibrio cholerae) 		PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478) 		5 PRO A  84
ILE A  68
PRO A  12
LEU A 102
TYR A  39
 None
 1.43A 2ze2A-4npaA:
undetectable		 2ze2A-4npaA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqv ALGM1
ALGM2

(Sphingomonas
sp.) 		PF00528
(BPD_transp_1) 		5 ILE A 147
ASN B 211
VAL B 271
PRO B 227
LEU B 232
 None
 0.76A 2ze2A-4tqvA:
undetectable		 2ze2A-4tqvA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BOTULINUM NEUROTOXIN
TYPE E,
NONTOXIC-NONHEMAGGLU
TININ COMPONENT,
NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		5 ILE B 234
ASN B 320
TYR B 240
PRO B 315
LEU B 303
 None
 1.34A 2ze2A-4zktB:
undetectable		 2ze2A-4zktB:
19.22