SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZBZ_A_VDXA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 ARG A 626
LEU A 746
VAL A 683
ILE A 681
ALA A 573
 None
 1.23A 2zbzA-1bf2A:
0.0		 2zbzA-1bf2A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dov ALPHA-CATENIN

(Mus musculus) 		PF01044
(Vinculin) 		5 LEU A 221
VAL A 218
ARG A 241
ILE A 161
ALA A 179
 None
 1.03A 2zbzA-1dovA:
undetectable		 2zbzA-1dovA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdz 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE

(Sulfolobus
solfataricus) 		PF01048
(PNP_UDP_1) 		5 SER A 156
LEU A 201
VAL A 203
ILE A 103
ALA A 208
 None
 1.11A 2zbzA-1jdzA:
0.0		 2zbzA-1jdzA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdz 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE

(Sulfolobus
solfataricus) 		PF01048
(PNP_UDP_1) 		5 VAL A 179
SER A 156
LEU A 201
VAL A 203
ALA A 208
 FMB  A 270 (-4.6A)
None
None
None
None
 1.22A 2zbzA-1jdzA:
0.0		 2zbzA-1jdzA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpt M-PROTEASE

(Bacillus
clausii) 		PF00082
(Peptidase_S8) 		5 SER A 221
LEU A  96
VAL A  95
ILE A 107
ALA A 114
 None
 1.17A 2zbzA-1mptA:
undetectable		 2zbzA-1mptA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 VAL A  17
VAL A  26
SER A  43
ILE A  49
ALA A 104
 None
 1.19A 2zbzA-1ozhA:
0.0		 2zbzA-1ozhA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1php 3-PHOSPHOGLYCERATE
KINASE

(Geobacillus
stearothermophilus) 		PF00162
(PGK) 		5 THR A  91
VAL A  88
VAL A  76
ILE A  37
ALA A  57
 None
 1.16A 2zbzA-1phpA:
0.0		 2zbzA-1phpA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qz9 KYNURENINASE

(Pseudomonas
fluorescens) 		PF00266
(Aminotran_5) 		5 LEU A 105
VAL A 104
MET A 170
ILE A 199
ALA A 237
 None
 1.22A 2zbzA-1qz9A:
0.0		 2zbzA-1qz9A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r18 PROTEIN-L-ISOASPARTA
TE(D-ASPARTATE)-O-ME
THYLTRANSFERASE

(Drosophila
melanogaster) 		PF01135
(PCMT) 		5 SER A 124
LEU A 141
SER A  87
ILE A 111
ALA A  31
 None
 1.22A 2zbzA-1r18A:
0.0		 2zbzA-1r18A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rt8 FIMBRIN

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		5 THR A 498
VAL A 614
SER A 520
MET A 521
ILE A 552
 None
 1.18A 2zbzA-1rt8A:
0.0		 2zbzA-1rt8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		5 THR C 317
LEU C 308
VAL C 309
SER C 241
ILE C 299
 None
 1.02A 2zbzA-1wa5C:
0.0		 2zbzA-1wa5C:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B

(Aspergillus
kawachii) 		PF05270
(AbfB)
PF09206
(ArabFuran-catal) 		5 THR A 170
SER A 268
VAL A 166
SER A 266
ILE A 328
 None
 1.23A 2zbzA-1wd3A:
undetectable		 2zbzA-1wd3A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x7p RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00588
(SpoU_methylase) 		5 THR A  36
VAL A 164
VAL A 185
ILE A 156
ALA A 114
 None
 1.22A 2zbzA-1x7pA:
undetectable		 2zbzA-1x7pA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekc TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Aquifex
aeolicus) 		PF00290
(Trp_syntA) 		5 VAL A 215
LEU A 252
VAL A 253
SER A 235
ALA A  18
 None
 1.14A 2zbzA-2ekcA:
undetectable		 2zbzA-2ekcA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		6 VAL A 194
VAL A 202
ARG A 197
SER A 355
ILE A 232
ALA A 271
 None
 1.42A 2zbzA-2eq9A:
undetectable		 2zbzA-2eq9A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fli RIBULOSE-PHOSPHATE
3-EPIMERASE

(Streptococcus
pyogenes) 		PF00834
(Ribul_P_3_epim) 		5 THR A  92
VAL A 132
SER A 170
ILE A 173
ALA A 122
 None
 1.24A 2zbzA-2fliA:
undetectable		 2zbzA-2fliA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jj4 ACETYLGLUTAMATE
KINASE

(Synechococcus
elongatus) 		PF00696
(AA_kinase) 		5 VAL A 110
VAL A 102
ARG A 109
ILE A  74
ALA A 188
 None
None
None
NLG  A1292 (-4.8A)
NLG  A1292 (-3.3A)
 1.14A 2zbzA-2jj4A:
undetectable		 2zbzA-2jj4A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfm ADENYLOSUCCINATE
LYASE

(Bacillus
anthracis) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 THR A 176
LEU A 322
SER A 234
ILE A 286
ALA A 222
 None
 1.17A 2zbzA-2pfmA:
undetectable		 2zbzA-2pfmA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pge MENC

(Desulfotalea
psychrophila) 		PF13378
(MR_MLE_C) 		5 SER A  94
ARG A  88
SER A  98
ILE A 103
ALA A 329
 None
 1.16A 2zbzA-2pgeA:
undetectable		 2zbzA-2pgeA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk3 GDP-6-DEOXY-D-LYXO-4
-HEXULOSE REDUCTASE

(Aneurinibacillus
thermoaerophilus) 		PF16363
(GDP_Man_Dehyd) 		5 THR A  88
VAL A 147
LEU A  97
VAL A  96
ILE A 109
 A2R  A 401 ( 4.1A)
None
None
None
None
 0.73A 2zbzA-2pk3A:
undetectable		 2zbzA-2pk3A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4

(Azotobacter
vinelandii) 		PF12708
(Pectate_lyase_3) 		5 LEU A 222
VAL A 252
MET A 209
ILE A 239
ALA A 280
 None
 1.13A 2zbzA-2pyhA:
undetectable		 2zbzA-2pyhA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyv XAA-HIS DIPEPTIDASE

(Histophilus
somni) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 THR A  62
VAL A 126
VAL A  71
ILE A 166
ALA A 481
 None
 1.22A 2zbzA-2qyvA:
undetectable		 2zbzA-2qyvA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rtx PEPTIDYL-TRNA
HYDROLASE YAEJ

(Escherichia
coli) 		PF00472
(RF-1) 		5 THR A 100
LEU A  91
VAL A  92
SER A  46
ILE A   2
 None
 1.08A 2zbzA-2rtxA:
undetectable		 2zbzA-2rtxA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Yersinia
enterocolitica) 		PF13416
(SBP_bac_8) 		5 VAL A 336
LEU A 341
VAL A 345
ILE A 361
ALA A 349
 None
 1.18A 2zbzA-2uvjA:
undetectable		 2zbzA-2uvjA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x75 ADENYLOSUCCINATE
LYASE

(Staphylococcus
aureus) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 LEU A 320
VAL A 316
SER A 232
ILE A 284
ALA A 220
 None
 1.15A 2zbzA-2x75A:
undetectable		 2zbzA-2x75A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xb6 NEUREXIN-1-BETA

(Rattus
norvegicus) 		PF02210
(Laminin_G_2) 		5 LEU C 126
VAL C 127
SER C 118
ILE C 115
ALA C 272
 None
 1.18A 2zbzA-2xb6C:
undetectable		 2zbzA-2xb6C:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 THR A 170
VAL A 479
LEU A 186
ILE A 486
ALA A 462
 None
 1.24A 2zbzA-2xf2A:
undetectable		 2zbzA-2xf2A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfs LEVANSUCRASE

(Lactobacillus
johnsonii) 		PF02435
(Glyco_hydro_68) 		5 ARG A 436
THR A 281
VAL A 428
VAL A 276
ILE A 351
 None
 1.07A 2zbzA-2yfsA:
undetectable		 2zbzA-2yfsA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		5 THR A  39
VAL A  22
ARG A 225
SER A 264
ALA A  14
 None
 1.11A 2zbzA-2ymuA:
undetectable		 2zbzA-2ymuA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG

(Mycobacterium
tuberculosis) 		PF01474
(DAHP_synth_2) 		5 SER A 136
VAL A 251
ARG A 135
SER A 146
ILE A 152
 None
None
None
SO4  A1467 ( 4.5A)
None
 1.17A 2zbzA-2ypqA:
undetectable		 2zbzA-2ypqA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		5 LEU A 541
VAL A 540
MET A 554
ILE A 557
ALA A 565
 None
 1.07A 2zbzA-3a5iA:
undetectable		 2zbzA-3a5iA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		5 THR A 330
VAL A  57
LEU A 341
ILE A  37
ALA A 325
 None
 1.14A 2zbzA-3ai7A:
undetectable		 2zbzA-3ai7A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1

(Homo sapiens) 		PF00071
(Ras) 		5 VAL A 236
LEU A 161
VAL A  18
SER A 241
ILE A  16
 None
 1.23A 2zbzA-3c5hA:
undetectable		 2zbzA-3c5hA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		5 LEU A 538
VAL A 537
SER A 522
ILE A 517
ALA A 418
 None
 1.24A 2zbzA-3dlaA:
undetectable		 2zbzA-3dlaA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0h AMINOTRANSFERASE

([Eubacterium]
rectale) 		PF00266
(Aminotran_5) 		5 THR A 136
VAL A 131
MET A 146
ILE A 147
ALA A 165
 LLP  A 187 ( 3.0A)
None
None
None
None
 1.19A 2zbzA-3f0hA:
undetectable		 2zbzA-3f0hA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyl TELOMERASE REVERSE
TRANSCRIPTASE

(Tribolium
castaneum) 		PF00078
(RVT_1)
PF12009
(Telomerase_RBD) 		5 VAL A 588
LEU A 581
VAL A 543
ILE A 472
ALA A 480
 None
 1.14A 2zbzA-3kylA:
undetectable		 2zbzA-3kylA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzw CYTOSOL
AMINOPEPTIDASE

(Staphylococcus
aureus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 THR A 446
VAL A 362
LEU A 256
ILE A 484
ALA A 384
 None
 1.23A 2zbzA-3kzwA:
undetectable		 2zbzA-3kzwA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 LEU B 161
VAL B 160
SER B 128
ILE B 175
ALA B  89
 None
 1.17A 2zbzA-3m2rB:
undetectable		 2zbzA-3m2rB:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odm PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Clostridium
perfringens) 		PF14010
(PEPcase_2) 		5 THR A  33
SER A 108
VAL A  45
ILE A  47
ALA A  26
 None
 1.17A 2zbzA-3odmA:
undetectable		 2zbzA-3odmA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oee ATP SYNTHASE SUBUNIT
ALPHA

(Saccharomyces
cerevisiae) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 VAL A  99
SER A 129
LEU A 105
ILE A 232
ALA A 236
 None
 1.17A 2zbzA-3oeeA:
undetectable		 2zbzA-3oeeA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 SER A 326
LEU A  26
MET A 331
ILE A  15
ALA A 338
 None
 1.11A 2zbzA-3oytA:
undetectable		 2zbzA-3oytA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p13 D-RIBOSE PYRANASE

(Staphylococcus
aureus) 		PF05025
(RbsD_FucU) 		5 VAL A  60
LEU A  44
SER A  14
ILE A  42
ALA A 129
 None
 1.23A 2zbzA-3p13A:
undetectable		 2zbzA-3p13A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Vibrio cholerae) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 VAL A 343
LEU A 261
VAL A 260
ILE A 333
ALA A 184
 None
 1.22A 2zbzA-3p4eA:
undetectable		 2zbzA-3p4eA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5s CD38 MOLECULE

(Bos taurus) 		PF02267
(Rib_hydrolayse) 		5 THR A 195
VAL A 198
SER A 119
LEU A 252
ILE A 249
 None
None
AVU  A 280 (-2.9A)
None
None
 1.21A 2zbzA-3p5sA:
undetectable		 2zbzA-3p5sA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		5 SER B1006
LEU B 866
VAL B 863
ILE B 910
ALA B1041
 None
 1.21A 2zbzA-3p8cB:
undetectable		 2zbzA-3p8cB:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 THR A 413
VAL A 387
MET A 454
ILE A 456
ALA A 477
 STU  A   1 (-3.9A)
None
None
None
STU  A   1 ( 4.1A)
 1.11A 2zbzA-3s95A:
undetectable		 2zbzA-3s95A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v47 FLAGELLIN

(Salmonella
enterica) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C) 		5 VAL C 164
SER C 166
LEU C  88
VAL C  91
ILE C 421
 None
 1.18A 2zbzA-3v47C:
undetectable		 2zbzA-3v47C:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vly NITRITE REDUCTASE

(Nicotiana
tabacum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 VAL A 422
VAL A 376
SER A 427
ILE A 371
ALA A 385
 None
 1.19A 2zbzA-3vlyA:
undetectable		 2zbzA-3vlyA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CMR6

(Archaeoglobus
fulgidus) 		PF03787
(RAMPs) 		6 THR H 248
LEU H 258
VAL H 291
SER H  33
ILE H 123
ALA H 245
 None
 1.32A 2zbzA-3x1lH:
undetectable		 2zbzA-3x1lH:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aal CYTOCHROME C551
PEROXIDASE

(Geobacter
sulfurreducens) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		5 THR A  89
SER A 269
VAL A 287
MET A 297
ILE A 296
 None
HEC  A 424 (-3.4A)
None
HEC  A 424 (-2.3A)
None
 1.22A 2zbzA-4aalA:
undetectable		 2zbzA-4aalA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Trypanosoma
brucei) 		PF01704
(UDPGP) 		5 THR A 465
SER A 493
LEU A 522
VAL A 518
ILE A 530
 None
 1.22A 2zbzA-4bqhA:
undetectable		 2zbzA-4bqhA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eud SUCCINYL-COA:ACETATE
COENZYME A
TRANSFERASE

(Acetobacter
aceti) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 VAL A 273
LEU A 246
SER A 268
MET A 360
ILE A 400
 None
 1.24A 2zbzA-4eudA:
undetectable		 2zbzA-4eudA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4faj PRGZ

(Enterococcus
faecalis) 		PF00496
(SBP_bac_5) 		6 VAL A  70
SER A 250
LEU A 241
VAL A  90
ILE A 255
ALA A 553
 None
None
None
None
None
GOL  A 602 (-3.7A)
 1.28A 2zbzA-4fajA:
undetectable		 2zbzA-4fajA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		5 LEU A 258
ARG A 340
SER A 456
ILE A 461
ALA A 477
 None
 1.16A 2zbzA-4iaoA:
undetectable		 2zbzA-4iaoA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iiw LMO1499 PROTEIN

(Listeria
monocytogenes) 		PF02618
(YceG) 		5 VAL A 252
LEU A 263
MET A 232
ILE A 235
ALA A 328
 None
 1.07A 2zbzA-4iiwA:
undetectable		 2zbzA-4iiwA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		5 THR A 365
VAL A 318
LEU A 305
ILE A 355
ALA A 413
 None
 1.24A 2zbzA-4kf7A:
undetectable		 2zbzA-4kf7A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3s DNA POLYMERASE ETA

(Homo sapiens) 		PF00817
(IMS)
PF11799
(IMS_C) 		5 VAL A 243
LEU A 225
VAL A 221
ILE A 255
ALA A 300
 None
 0.96A 2zbzA-4o3sA:
undetectable		 2zbzA-4o3sA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3s DNA POLYMERASE ETA

(Homo sapiens) 		PF00817
(IMS)
PF11799
(IMS_C) 		5 VAL A 243
LEU A 225
VAL A 221
MET A 250
ALA A 300
 None
 1.25A 2zbzA-4o3sA:
undetectable		 2zbzA-4o3sA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pic ARGININE PHOSPHATASE
YWLE

(Geobacillus
stearothermophilus) 		PF01451
(LMWPc) 		5 THR A  82
SER A  65
LEU A   5
VAL A  78
ILE A  72
 None
 1.23A 2zbzA-4picA:
undetectable		 2zbzA-4picA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgk UNCHARACTERIZED
PROTEIN

(Yersinia pestis) 		PF07350
(DUF1479) 		5 THR A 180
LEU A 159
VAL A 155
ILE A  86
ALA A 146
 None
 1.17A 2zbzA-4rgkA:
undetectable		 2zbzA-4rgkA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr6 DNA POLYMERASE III
SUBUNIT BETA

(Bacillus
subtilis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 SER A 352
LEU A 344
VAL A 343
ILE A 370
ALA A 180
 None
 1.23A 2zbzA-4tr6A:
undetectable		 2zbzA-4tr6A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 VAL A 254
VAL A 351
SER A 169
ILE A 348
ALA A 176
 None
 1.25A 2zbzA-4ud8A:
undetectable		 2zbzA-4ud8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufc GH95

(Bacteroides
ovatus) 		PF14498
(Glyco_hyd_65N_2) 		5 VAL A 679
LEU A 332
MET A 638
ILE A 639
ALA A 700
 None
 1.19A 2zbzA-4ufcA:
undetectable		 2zbzA-4ufcA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw2 CSM1

(Thermococcus
onnurineus) 		PF01966
(HD) 		5 SER A 172
LEU A 278
VAL A 274
ILE A 298
ALA A 292
 None
 1.23A 2zbzA-4uw2A:
undetectable		 2zbzA-4uw2A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio cholerae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 SER A 322
LEU A  26
MET A 327
ILE A  15
ALA A 334
 None
 1.09A 2zbzA-4xoxA:
undetectable		 2zbzA-4xoxA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio cholerae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 SER A 322
LEU A  26
VAL A  22
MET A 327
ILE A  15
 None
 1.21A 2zbzA-4xoxA:
undetectable		 2zbzA-4xoxA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoq INTRACELLULAR SERINE
PROTEASE

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		5 THR I 204
SER I 376
LEU I 209
VAL I 208
ALA I 226
 None
 1.23A 2zbzA-4zoqI:
undetectable		 2zbzA-4zoqI:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3

(Acinetobacter
baumannii) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		5 THR A 790
LEU A 646
SER A 672
ILE A 678
ALA A 772
 None
 1.19A 2zbzA-4zxiA:
undetectable		 2zbzA-4zxiA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cej 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Yersinia pestis) 		PF13561
(adh_short_C2) 		5 THR A 175
SER A 113
VAL A 179
ILE A 136
ALA A 223
 None
 1.21A 2zbzA-5cejA:
undetectable		 2zbzA-5cejA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwp DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 5 VAL A 188
SER A 190
LEU A 153
VAL A 154
ALA A  81
 None
 1.14A 2zbzA-5cwpA:
undetectable		 2zbzA-5cwpA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fi5 TETRAHYDROALSTONINE
SYNTHASE

(Catharanthus
roseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 206
SER A 227
LEU A 244
ILE A 247
ALA A 167
 None
 1.18A 2zbzA-5fi5A:
undetectable		 2zbzA-5fi5A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 VAL q 189
SER q 379
VAL q 182
ILE q 384
ALA q 406
 None
 1.16A 2zbzA-5gw5q:
undetectable		 2zbzA-5gw5q:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Dictyostelium
discoideum;
Homo sapiens) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 LEU A 815
VAL A 816
SER A 861
ILE A 893
ALA A 899
 None
 1.07A 2zbzA-5i4eA:
undetectable		 2zbzA-5i4eA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jos CYCLOHEXADIENYL
DEHYDRATASE

(synthetic
construct) 		PF00497
(SBP_bac_3) 		5 VAL A 224
LEU A  16
SER A  59
ILE A  19
ALA A  86
 None
 1.00A 2zbzA-5josA:
undetectable		 2zbzA-5josA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzw AEROLYSIN

(Aeromonas
hydrophila) 		PF01117
(Aerolysin)
PF03440
(APT) 		5 LEU A 393
VAL A 392
SER A 354
ILE A 345
ALA A 120
 None
 1.21A 2zbzA-5jzwA:
undetectable		 2zbzA-5jzwA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		5 THR A 174
VAL A 180
LEU A 244
ILE A 246
ALA A 161
 None
 1.21A 2zbzA-5kdxA:
undetectable		 2zbzA-5kdxA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA

(Homo sapiens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 LEU B 587
VAL B 614
SER B 602
ILE B 611
ALA B 630
 None
 1.14A 2zbzA-5l3qB:
undetectable		 2zbzA-5l3qB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA

(Homo sapiens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 VAL B 597
LEU B 587
VAL B 614
SER B 602
ILE B 611
 None
 1.18A 2zbzA-5l3qB:
undetectable		 2zbzA-5l3qB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA

(Pyrococcus
furiosus) 		PF08423
(Rad51) 		5 VAL A 136
LEU A 120
SER A 142
ILE A 347
ALA A 152
 None
None
PO4  A 401 (-4.8A)
None
None
 1.17A 2zbzA-5l8vA:
undetectable		 2zbzA-5l8vA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltq GREEN FLUORESCENT
PROTEIN BLFP-Y3

(Branchiostoma
lanceolatum) 		PF01353
(GFP) 		5 THR A 120
LEU A  53
SER A  41
MET A  22
ILE A  11
 None
 0.82A 2zbzA-5ltqA:
undetectable		 2zbzA-5ltqA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6

(Azotobacter
vinelandii) 		no annotation 5 LEU A 222
VAL A 252
MET A 209
ILE A 239
ALA A 280
 None
 1.24A 2zbzA-5lw3A:
undetectable		 2zbzA-5lw3A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 VAL A 272
SER A 274
LEU A 293
VAL A 294
ALA B 283
 None
 1.22A 2zbzA-5mkkA:
undetectable		 2zbzA-5mkkA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mte PUTATIVE
UNCHARACTERIZED
PROTEIN ORF60T

(Vibrio phage
phi16) 		no annotation 5 THR A  36
VAL A  48
LEU A  27
VAL A  28
ILE A  54
 None
 1.19A 2zbzA-5mteA:
undetectable		 2zbzA-5mteA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC

(synthetic
construct) 		no annotation 5 THR D 130
LEU D  63
SER D  51
MET D  32
ILE D  21
 None
 0.87A 2zbzA-5mwcD:
undetectable		 2zbzA-5mwcD:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 5 THR B 342
VAL B  85
LEU B 184
VAL B 185
ALA B 335
 None
 1.16A 2zbzA-5my0B:
undetectable		 2zbzA-5my0B:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oo7 SLA2

(Chaetomium
thermophilum) 		no annotation 5 LEU A 164
SER A 211
MET A 212
ILE A 161
ALA A 235
 None
 1.17A 2zbzA-5oo7A:
undetectable		 2zbzA-5oo7A:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ov3 RETINOBLASTOMA-BINDI
NG PROTEIN 5

(Mus musculus) 		no annotation 5 SER A 314
LEU A 276
VAL A 267
SER A 319
ILE A 310
 None
 1.17A 2zbzA-5ov3A:
undetectable		 2zbzA-5ov3A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqb 60S RIBOSOMAL
PROTEIN L4-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00573
(Ribosomal_L4) 		5 THR A 145
VAL A 182
VAL A 256
ILE A 211
ALA A 175
 None
None
EDO  A 301 ( 4.7A)
None
None
 1.21A 2zbzA-5tqbA:
undetectable		 2zbzA-5tqbA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue0 CT622 PROTEIN

(Chlamydia
trachomatis) 		no annotation 5 THR A 473
LEU A 555
VAL A 551
SER A 534
ILE A 541
 None
 1.20A 2zbzA-5ue0A:
undetectable		 2zbzA-5ue0A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w81 CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Danio rerio) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		5 THR A1424
SER A1253
LEU A1216
ILE A1268
ALA A1235
 None
ATP  A1502 (-3.5A)
None
None
None
 1.18A 2zbzA-5w81A:
undetectable		 2zbzA-5w81A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqn PROBABLE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00106
(adh_short) 		5 VAL A 220
LEU A 204
SER A 134
MET A 133
ILE A  81
 None
 1.19A 2zbzA-5wqnA:
undetectable		 2zbzA-5wqnA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7u TREHALOSE SYNTHASE

(Thermobaculum
terrenum) 		no annotation 5 THR A 365
SER A 352
LEU A 278
ARG A 355
ALA A 488
 None
MG  A 603 (-3.6A)
None
MG  A 603 (-3.2A)
None
 1.25A 2zbzA-5x7uA:
undetectable		 2zbzA-5x7uA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8t 50S RIBOSOMAL
PROTEIN L4,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00573
(Ribosomal_L4) 		5 THR E  68
VAL E 169
SER E 167
LEU E 245
VAL E 246
 None
 1.20A 2zbzA-5x8tE:
undetectable		 2zbzA-5x8tE:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo6 -

(-) 		no annotation 5 THR A 455
VAL A 289
VAL A 418
ARG A 288
ILE A 296
 None
 0.93A 2zbzA-6bo6A:
undetectable		 2zbzA-6bo6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d4j PROTEIN PATCHED
HOMOLOG 1

(Homo sapiens) 		no annotation 5 VAL A1035
SER A1033
VAL A1084
ILE A 565
ALA A 578
 None
 1.01A 2zbzA-6d4jA:
undetectable		 2zbzA-6d4jA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et0 PQSB

(Pseudomonas
aeruginosa) 		no annotation 5 SER B 262
LEU B 150
VAL B   6
ILE B   3
ALA B 249
 None
 1.13A 2zbzA-6et0B:
undetectable		 2zbzA-6et0B:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fml RUVB-LIKE HELICASE

(Chaetomium
thermophilum) 		no annotation 5 VAL D  73
VAL D 294
ARG D  71
MET D  62
ILE D  63
 None
 1.25A 2zbzA-6fmlD:
undetectable		 2zbzA-6fmlD:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3d ARGININOSUCCINATE
LYASE

(Chelativorans
sp. BNC1) 		no annotation 5 THR A 419
LEU A 410
VAL A 411
ILE A 406
ALA A 385
 None
 1.06A 2zbzA-6g3dA:
undetectable		 2zbzA-6g3dA:
12.13