SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZBU_D_ADND504_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bvy | PROTEIN (CYTOCHROMEP450 BM-3) (Bacillusmegaterium) |
PF00258(Flavodoxin_1) | 3 | PHE F 628ASN F 629PHE F 509 | None | 0.88A | 2zbuD-1bvyF:2.7 | 2zbuD-1bvyF:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cp9 | PENICILLIN G AMIDASE (Providenciarettgeri) |
PF01804(Penicil_amidase) | 3 | PHE B 460ASN B 458PHE B 50 | None | 1.06A | 2zbuD-1cp9B:undetectable | 2zbuD-1cp9B:17.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eg7 | FORMYLTETRAHYDROFOLATE SYNTHETASE (Moorellathermoacetica) |
PF01268(FTHFS) | 3 | PHE A1275ASN A1277PHE A1304 | NoneNoneSO4 A 1 (-4.8A) | 1.04A | 2zbuD-1eg7A:2.4 | 2zbuD-1eg7A:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ezv | UBIQUINOL-CYTOCHROMEC REDUCTASE COMPLEXCORE PROTEIN I (Saccharomycescerevisiae) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C) | 3 | PHE A 76ASN A 81PHE A 118 | None | 0.99A | 2zbuD-1ezvA:undetectable | 2zbuD-1ezvA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gp1 | GLUTATHIONEPEROXIDASE (Bos taurus) |
PF00255(GSHPx) | 3 | PHE A 105ASN A 56PHE A 101 | None | 0.99A | 2zbuD-1gp1A:undetectable | 2zbuD-1gp1A:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ipk | BETA-CONGLYCININ,BETA CHAIN (Glycine max) |
PF00190(Cupin_1)PF07883(Cupin_2) | 3 | PHE A 11ASN A 9PHE A 317 | None | 1.04A | 2zbuD-1ipkA:undetectable | 2zbuD-1ipkA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kb0 | QUINOHEMOPROTEINALCOHOLDEHYDROGENASE (Comamonastestosteroni) |
PF13360(PQQ_2)PF13442(Cytochrome_CBB3) | 3 | PHE A 338ASN A 336PHE A 340 | None | 0.99A | 2zbuD-1kb0A:undetectable | 2zbuD-1kb0A:16.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kcw | CERULOPLASMIN (Homo sapiens) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 3 | PHE A 748ASN A 746PHE A 947 | None | 0.55A | 2zbuD-1kcwA:undetectable | 2zbuD-1kcwA:15.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lxy | ARGININE DEIMINASE (Mycoplasmaarginini) |
PF02274(Amidinotransf) | 3 | PHE A 158ASN A 155PHE A 45 | CIR A 500 ( 3.8A)CIR A 500 (-3.6A)CIR A 500 ( 4.9A) | 1.07A | 2zbuD-1lxyA:undetectable | 2zbuD-1lxyA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m2v | PROTEIN TRANSPORTPROTEIN SEC24 (Saccharomycescerevisiae) |
PF00626(Gelsolin)PF04810(zf-Sec23_Sec24)PF04811(Sec23_trunk)PF04815(Sec23_helical)PF08033(Sec23_BS) | 3 | PHE B 241ASN B 239PHE B 255 | None | 0.90A | 2zbuD-1m2vB:2.8 | 2zbuD-1m2vB:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pd1 | PROTEIN TRANSPORTPROTEIN SEC24 (Saccharomycescerevisiae) |
PF00626(Gelsolin)PF04810(zf-Sec23_Sec24)PF04811(Sec23_trunk)PF04815(Sec23_helical)PF08033(Sec23_BS) | 3 | PHE A 241ASN A 239PHE A 255 | None | 0.83A | 2zbuD-1pd1A:2.9 | 2zbuD-1pd1A:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qho | ALPHA-AMYLASE (Geobacillusstearothermophilus) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG)PF02806(Alpha-amylase_C) | 3 | PHE A 294ASN A 342PHE A 297 | None | 0.99A | 2zbuD-1qhoA:undetectable | 2zbuD-1qhoA:16.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sb7 | TRNA PSEUDOURIDINESYNTHASE D (Escherichiacoli) |
PF01142(TruD) | 3 | PHE A 160ASN A 204PHE A 165 | None | 0.88A | 2zbuD-1sb7A:undetectable | 2zbuD-1sb7A:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u2e | 2-HYDROXY-6-KETONONA-2,4-DIENEDIOIC ACIDHYDROLASE (Escherichiacoli) |
PF12697(Abhydrolase_6) | 3 | PHE A 50ASN A 53PHE A 273 | None | 1.09A | 2zbuD-1u2eA:2.9 | 2zbuD-1u2eA:23.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uik | ALPHA PRIME SUBUNITOF BETA-CONGLYCININ (Glycine max) |
PF00190(Cupin_1) | 3 | PHE A 150ASN A 148PHE A 460 | None | 1.02A | 2zbuD-1uikA:undetectable | 2zbuD-1uikA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vfg | POLY A POLYMERASE (Aquifexaeolicus) |
PF01743(PolyA_pol) | 3 | PHE A 106ASN A 109PHE A 159 | None | 1.02A | 2zbuD-1vfgA:undetectable | 2zbuD-1vfgA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xn6 | HYPOTHETICAL PROTEINBC4709 (Bacillus cereus) |
PF08327(AHSA1) | 3 | PHE A 42ASN A 40PHE A 37 | None | 0.77A | 2zbuD-1xn6A:undetectable | 2zbuD-1xn6A:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xrs | D-LYSINE5,6-AMINOMUTASEALPHA SUBUNIT (Acetoanaerobiumsticklandii) |
PF09043(Lys-AminoMut_A) | 3 | PHE A 509ASN A 507PHE A 281 | None | 1.02A | 2zbuD-1xrsA:undetectable | 2zbuD-1xrsA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ybf | AMP NUCLEOSIDASE (Bacteroidesthetaiotaomicron) |
PF01048(PNP_UDP_1) | 3 | PHE A 34ASN A 33PHE A 93 | None | 0.95A | 2zbuD-1ybfA:2.8 | 2zbuD-1ybfA:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z2z | PROBABLE TRNAPSEUDOURIDINESYNTHASE D (Methanosarcinamazei) |
PF01142(TruD) | 3 | PHE A 170ASN A 279PHE A 175 | None | 0.92A | 2zbuD-1z2zA:undetectable | 2zbuD-1z2zA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b3d | MODULATOR OF DRUGACTIVITY B (Escherichiacoli) |
PF02525(Flavodoxin_2) | 3 | PHE A 162ASN A 166PHE A 97 | None | 1.06A | 2zbuD-2b3dA:2.1 | 2zbuD-2b3dA:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c4t | 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE (Streptomycescattleya) |
PF01887(SAM_adeno_trans) | 3 | PHE A 213ASN A 215PHE A 254 | None | 0.29A | 2zbuD-2c4tA:30.3 | 2zbuD-2c4tA:28.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cv6 | SEED STORAGE PROTEIN (Vigna radiata) |
PF00190(Cupin_1) | 3 | PHE A 16ASN A 14PHE A 328 | None | 1.02A | 2zbuD-2cv6A:undetectable | 2zbuD-2cv6A:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dd7 | GREEN FLUORESCENTPROTEIN (Chiridiuspoppei) |
PF01353(GFP) | 3 | PHE A 119ASN A 15PHE A 126 | None | 0.89A | 2zbuD-2dd7A:undetectable | 2zbuD-2dd7A:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dw1 | CATROCOLLASTATIN (Crotalus atrox) |
PF00200(Disintegrin)PF01421(Reprolysin)PF08516(ADAM_CR) | 3 | PHE A 197ASN A 195PHE A 199 | None | 0.93A | 2zbuD-2dw1A:3.4 | 2zbuD-2dw1A:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eaa | 7S GLOBULIN-3 (Vigna angularis) |
PF00190(Cupin_1) | 3 | PHE A 22ASN A 20PHE A 332 | None | 0.99A | 2zbuD-2eaaA:undetectable | 2zbuD-2eaaA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ehq | 1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE (Thermusthermophilus) |
PF00171(Aldedh) | 3 | PHE A 506ASN A 202PHE A 255 | None | 1.07A | 2zbuD-2ehqA:2.6 | 2zbuD-2ehqA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g6y | GREEN FLUORESCENTPROTEIN 2 (Pontellinaplumata) |
PF01353(GFP) | 3 | PHE A 121ASN A 15PHE A 128 | None | 0.93A | 2zbuD-2g6yA:undetectable | 2zbuD-2g6yA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2glj | PROBABLE M18-FAMILYAMINOPEPTIDASE 1 (Clostridiumacetobutylicum) |
PF02127(Peptidase_M18) | 3 | PHE A 309ASN A 312PHE A 88 | None | 1.05A | 2zbuD-2gljA:undetectable | 2zbuD-2gljA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gw3 | KAEDE (Trachyphylliageoffroyi) |
PF01353(GFP) | 3 | PHE A 114ASN A 65PHE A 87 | NoneCR8 A 63 ( 4.8A)None | 0.87A | 2zbuD-2gw3A:undetectable | 2zbuD-2gw3A:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gw4 | KAEDE (Trachyphylliageoffroyi) |
PF01353(GFP) | 3 | PHE B 114ASN B 65PHE B 87 | NoneRC7 B 63 ( 4.8A)None | 0.85A | 2zbuD-2gw4B:undetectable | 2zbuD-2gw4B:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hpi | DNA POLYMERASE IIIALPHA SUBUNIT (Thermusaquaticus) |
PF02811(PHP)PF07733(DNA_pol3_alpha)PF14579(HHH_6) | 3 | PHE A 915ASN A 874PHE A 947 | None | 1.06A | 2zbuD-2hpiA:undetectable | 2zbuD-2hpiA:12.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i3y | EPIDIDYMAL SECRETORYGLUTATHIONEPEROXIDASE (Homo sapiens) |
PF00255(GSHPx) | 3 | PHE A 132ASN A 83PHE A 128 | None | 1.02A | 2zbuD-2i3yA:undetectable | 2zbuD-2i3yA:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ijx | DNA POLYMERASESLIDING CLAMP A (Sulfolobussolfataricus) |
PF00705(PCNA_N)PF02747(PCNA_C) | 3 | PHE A 67ASN A 113PHE A 65 | None | 0.94A | 2zbuD-2ijxA:undetectable | 2zbuD-2ijxA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nya | PERIPLASMIC NITRATEREDUCTASE (Escherichiacoli) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4) | 3 | PHE A 758ASN A 766PHE A 782 | MGD A3001 (-3.9A)MGD A3001 (-2.8A)MGD A3001 (-3.6A) | 0.72A | 2zbuD-2nyaA:2.9 | 2zbuD-2nyaA:16.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o62 | HYPOTHETICAL PROTEIN (Nostocpunctiforme) |
PF12204(DUF3598) | 3 | PHE A 8ASN A 11PHE A 78 | None | 1.00A | 2zbuD-2o62A:undetectable | 2zbuD-2o62A:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2phl | PHASEOLIN (Phaseolusvulgaris) |
PF00190(Cupin_1) | 3 | PHE A 14ASN A 12PHE A 300 | None | 0.99A | 2zbuD-2phlA:undetectable | 2zbuD-2phlA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q01 | URONATE ISOMERASE (Caulobactervibrioides) |
PF02614(UxaC) | 3 | PHE A 121ASN A 118PHE A 130 | None | 0.89A | 2zbuD-2q01A:undetectable | 2zbuD-2q01A:18.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2q6k | CHLORINASE (Salinisporatropica) |
PF01887(SAM_adeno_trans) | 3 | PHE A 186ASN A 188PHE A 228 | None | 0.14A | 2zbuD-2q6kA:31.4 | 2zbuD-2q6kA:32.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r37 | GLUTATHIONEPEROXIDASE 3 (Homo sapiens) |
PF00255(GSHPx) | 3 | PHE A 132ASN A 83PHE A 128 | None | 1.07A | 2zbuD-2r37A:undetectable | 2zbuD-2r37A:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r3s | UNCHARACTERIZEDPROTEIN (Nostocpunctiforme) |
PF00891(Methyltransf_2)PF16864(Dimerisation2) | 3 | PHE A 269ASN A 239PHE A 271 | None CL A 335 ( 4.3A)None | 0.92A | 2zbuD-2r3sA:undetectable | 2zbuD-2r3sA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r73 | TRICHOSURIN (Trichosurusvulpecula) |
PF00061(Lipocalin) | 3 | PHE A 112ASN A 127PHE A 114 | None | 1.08A | 2zbuD-2r73A:undetectable | 2zbuD-2r73A:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rgy | TRANSCRIPTIONALREGULATOR, LACIFAMILY (Paraburkholderiaphymatum) |
PF13377(Peripla_BP_3) | 3 | PHE A 344ASN A 327PHE A 347 | None | 1.09A | 2zbuD-2rgyA:5.6 | 2zbuD-2rgyA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rh7 | GREEN FLUORESCENTPROTEIN (Renillareniformis) |
PF01353(GFP) | 3 | PHE A 118ASN A 69PHE A 91 | NoneCRO A 66 ( 4.8A)None | 0.87A | 2zbuD-2rh7A:undetectable | 2zbuD-2rh7A:24.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yv9 | CHLORIDEINTRACELLULARCHANNEL EXC-4 (Caenorhabditiselegans) |
no annotation | 3 | PHE A 38ASN A 93PHE A 42 | None CA A1002 (-3.8A)None | 0.99A | 2zbuD-2yv9A:undetectable | 2zbuD-2yv9A:21.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zbv | UNCHARACTERIZEDCONSERVED PROTEIN (Thermotogamaritima) |
PF01887(SAM_adeno_trans) | 3 | PHE A 180ASN A 182PHE A 220 | None | 0.08A | 2zbuD-2zbvA:41.5 | 2zbuD-2zbvA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a9v | 4-COUMARATE--COALIGASE (Populustomentosa) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 3 | PHE A 107ASN A 105PHE A 442 | None | 1.09A | 2zbuD-3a9vA:undetectable | 2zbuD-3a9vA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a9v | 4-COUMARATE--COALIGASE (Populustomentosa) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 3 | PHE A 107ASN A 105PHE A 503 | None | 1.01A | 2zbuD-3a9vA:undetectable | 2zbuD-3a9vA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aqk | POLY(A) POLYMERASE (Escherichiacoli) |
PF01743(PolyA_pol)PF12626(PolyA_pol_arg_C)PF12627(PolyA_pol_RNAbd) | 3 | PHE A 152ASN A 155PHE A 204 | None | 1.09A | 2zbuD-3aqkA:undetectable | 2zbuD-3aqkA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b4w | ALDEHYDEDEHYDROGENASE (Mycobacteriumtuberculosis) |
PF00171(Aldedh) | 3 | PHE A 452ASN A 464PHE A 161 | NAD A 500 (-4.6A)NoneGOL A 602 (-4.0A) | 0.94A | 2zbuD-3b4wA:undetectable | 2zbuD-3b4wA:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c6g | CYTOCHROME P450 2R1 (Homo sapiens) |
PF00067(p450) | 3 | PHE A 196ASN A 192PHE A 207 | None | 0.91A | 2zbuD-3c6gA:undetectable | 2zbuD-3c6gA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c9f | 5'-NUCLEOTIDASE (Candidaalbicans) |
PF00149(Metallophos) | 3 | PHE A 410ASN A 412PHE A 521 | None | 0.90A | 2zbuD-3c9fA:undetectable | 2zbuD-3c9fA:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cgg | SAM-DEPENDENTMETHYLTRANSFERASE (Corynebacteriumglutamicum) |
PF13649(Methyltransf_25) | 3 | PHE A 146ASN A 115PHE A 186 | None | 0.94A | 2zbuD-3cggA:undetectable | 2zbuD-3cggA:23.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3czb | PUTATIVETRANSGLYCOSYLASE (Caulobactervibrioides) |
PF03562(MltA)PF06725(3D) | 3 | PHE A 245ASN A 287PHE A 215 | None | 1.09A | 2zbuD-3czbA:undetectable | 2zbuD-3czbA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3do6 | FORMATE--TETRAHYDROFOLATE LIGASE (Thermotogamaritima) |
PF01268(FTHFS) | 3 | PHE A 260ASN A 262PHE A 289 | None | 1.02A | 2zbuD-3do6A:undetectable | 2zbuD-3do6A:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ecq | ENDO-ALPHA-N-ACETYLGALACTOSAMINIDASE (Streptococcuspneumoniae) |
PF12905(Glyco_hydro_101)PF17451(Glyco_hyd_101C) | 3 | PHE A 367ASN A 453PHE A 347 | None | 0.59A | 2zbuD-3ecqA:undetectable | 2zbuD-3ecqA:10.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f0h | AMINOTRANSFERASE ([Eubacterium]rectale) |
PF00266(Aminotran_5) | 3 | PHE A 271ASN A 341PHE A 4 | None | 0.82A | 2zbuD-3f0hA:undetectable | 2zbuD-3f0hA:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fdg | DIPEPTIDASE AC.METALLO PEPTIDASE.MEROPS FAMILY M19 (Rhodobactersphaeroides) |
PF01244(Peptidase_M19) | 3 | PHE A 14ASN A 12PHE A 53 | None | 1.09A | 2zbuD-3fdgA:undetectable | 2zbuD-3fdgA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fr8 | PUTATIVE KETOL-ACIDREDUCTOISOMERASE(OS05G0573700PROTEIN) (Oryza sativa) |
PF01450(IlvC)PF07991(IlvN) | 3 | PHE A 302ASN A 274PHE A 304 | None | 1.01A | 2zbuD-3fr8A:undetectable | 2zbuD-3fr8A:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fvw | PUTATIVENAD(P)H-DEPENDENTFMN REDUCTASE (Streptococcusmutans) |
PF03358(FMN_red) | 3 | PHE A 46ASN A 88PHE A 45 | None | 1.03A | 2zbuD-3fvwA:3.1 | 2zbuD-3fvwA:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3giu | PYRROLIDONE-CARBOXYLATE PEPTIDASE (Staphylococcusaureus) |
PF01470(Peptidase_C15) | 3 | PHE A 8ASN A 17PHE A 11 | ACY A 214 (-4.2A)ACY A 214 (-3.2A)ACY A 214 (-4.0A) | 1.07A | 2zbuD-3giuA:3.0 | 2zbuD-3giuA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gra | TRANSCRIPTIONALREGULATOR, ARACFAMILY (Pseudomonasputida) |
PF01965(DJ-1_PfpI) | 3 | PHE A 63ASN A 56PHE A 65 | None | 0.96A | 2zbuD-3graA:2.7 | 2zbuD-3graA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h2i | ESTERASE (Xanthomonasoryzae) |
PF03583(LIP) | 3 | PHE A 302ASN A 308PHE A 298 | None | 1.06A | 2zbuD-3h2iA:undetectable | 2zbuD-3h2iA:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iqd | OCTOPINEDEHYDROGENASE (Pecten maximus) |
PF02317(Octopine_DH) | 3 | PHE B 210ASN B 351PHE B 337 | None | 0.75A | 2zbuD-3iqdB:undetectable | 2zbuD-3iqdB:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m99 | UBIQUITINCARBOXYL-TERMINALHYDROLASE 8 (Saccharomycescerevisiae) |
PF00443(UCH)PF02148(zf-UBP) | 3 | PHE A 464ASN A 158PHE A 279 | None | 0.79A | 2zbuD-3m99A:undetectable | 2zbuD-3m99A:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ndy | ENDOGLUCANASE D (Clostridiumcellulovorans) |
PF00150(Cellulase) | 3 | PHE A 96ASN A 93PHE A 7 | None | 1.06A | 2zbuD-3ndyA:undetectable | 2zbuD-3ndyA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sn0 | PUTATIVEL-ALANINE-DL-GLUTAMATE EPIMERASE (Paraburkholderiaxenovorans) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | PHE A 270ASN A 294PHE A 275 | None | 1.05A | 2zbuD-3sn0A:undetectable | 2zbuD-3sn0A:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sun | DNA POLYMERASE (Escherichiavirus RB69) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 3 | PHE A 280ASN A 558PHE A 282 | None | 1.09A | 2zbuD-3sunA:2.1 | 2zbuD-3sunA:15.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vn5 | RIBONUCLEASE HIII (Aquifexaeolicus) |
PF01351(RNase_HII) | 3 | PHE A 187ASN A 185PHE A 193 | None | 0.95A | 2zbuD-3vn5A:undetectable | 2zbuD-3vn5A:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wky | PROPHENOLOXIDASE B (Marsupenaeusjaponicus) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 3 | PHE A 567ASN A 194PHE A 479 | None | 0.86A | 2zbuD-3wkyA:undetectable | 2zbuD-3wkyA:17.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wo0 | ALANINE-ANTICAPSINLIGASE BACD (Bacillussubtilis) |
PF13535(ATP-grasp_4) | 3 | PHE A 329ASN A 107PHE A 20 | None | 0.95A | 2zbuD-3wo0A:3.0 | 2zbuD-3wo0A:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zus | BOTULINUM NEUROTOXINTYPE A,SYNAPTOSOMAL-ASSOCIATED PROTEIN 23 (Clostridiumbotulinum;Homo sapiens) |
PF01742(Peptidase_M27)PF07952(Toxin_trans) | 3 | PHE A 425ASN A 509PHE A 587 | None | 1.09A | 2zbuD-3zusA:undetectable | 2zbuD-3zusA:13.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4evq | PUTATIVE ABCTRANSPORTER SUBUNIT,SUBSTRATE-BINDINGCOMPONENT (Rhodopseudomonaspalustris) |
PF13458(Peripla_BP_6) | 3 | PHE A 306ASN A 130PHE A 150 | PHB A 406 (-4.4A)PHB A 406 (-3.7A)None | 1.00A | 2zbuD-4evqA:4.4 | 2zbuD-4evqA:23.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i8v | CYTOCHROME P450 1A1 (Homo sapiens) |
PF00067(p450) | 3 | PHE A 224ASN A 222PHE A 319 | BHF A 602 (-3.3A)BHF A 602 ( 3.8A)BHF A 602 ( 4.7A) | 0.94A | 2zbuD-4i8vA:undetectable | 2zbuD-4i8vA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p7y | METHIONINEGAMMA-LYASE (Citrobacterfreundii) |
PF01053(Cys_Met_Meta_PP) | 3 | PHE A 32ASN A 63PHE A 37 | None | 0.94A | 2zbuD-4p7yA:undetectable | 2zbuD-4p7yA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qdf | 3-KETOSTEROID9ALPHA-HYDROXYLASEOXYGENASE (Rhodococcusrhodochrous) |
PF00355(Rieske) | 3 | PHE B 354ASN B 195PHE B 193 | None | 1.05A | 2zbuD-4qdfB:undetectable | 2zbuD-4qdfB:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qg5 | PUTATIVEPHOSPHOGLUCOMUTASE (Leishmaniamajor) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 3 | PHE A 313ASN A 280PHE A 312 | None | 0.91A | 2zbuD-4qg5A:undetectable | 2zbuD-4qg5A:18.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yjf | D-AMINO-ACID OXIDASE (Sus scrofa) |
PF01266(DAO) | 3 | PHE B 133ASN B 134PHE B 213 | None | 1.05A | 2zbuD-4yjfB:4.3 | 2zbuD-4yjfB:23.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yxt | POLYKETIDEBIOSYNTHESIS3-HYDROXY-3-METHYLGLUTARYL-ACP SYNTHASEPKSG (Bacillussubtilis) |
PF01154(HMG_CoA_synt_N)PF08540(HMG_CoA_synt_C) | 3 | PHE A 54ASN A 57PHE A 405 | None | 1.03A | 2zbuD-4yxtA:undetectable | 2zbuD-4yxtA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z9n | AMINO ACID ABCTRANSPORTER,PERIPLASMIC AMINOACID-BINDING PROTEIN (Brucella ovis) |
PF00497(SBP_bac_3) | 3 | PHE A 206ASN A 100PHE A 37 | None | 1.00A | 2zbuD-4z9nA:undetectable | 2zbuD-4z9nA:23.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zba | PCURE2P8 (Phanerochaetechrysosporium) |
PF00043(GST_C)PF02798(GST_N) | 3 | PHE A 173ASN A 177PHE A 119 | None | 0.85A | 2zbuD-4zbaA:2.5 | 2zbuD-4zbaA:23.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zkt | BONTOXILYSIN A (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07951(Toxin_R_bind_C)PF07952(Toxin_trans)PF07953(Toxin_R_bind_N) | 3 | PHE A 520ASN A 518PHE A 411 | None | 0.94A | 2zbuD-4zktA:undetectable | 2zbuD-4zktA:11.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a4j | FORMATE--TETRAHYDROFOLATE LIGASE (Tepidanaerobacteracetatoxydans) |
PF01268(FTHFS) | 3 | PHE A 274ASN A 276PHE A 303 | NoneNoneEDO A1560 ( 4.2A) | 1.01A | 2zbuD-5a4jA:2.6 | 2zbuD-5a4jA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a55 | ENDO-ALPHA-N-ACETYLGALACTOSAMINIDASE (Streptococcuspneumoniae) |
PF12905(Glyco_hydro_101)PF17451(Glyco_hyd_101C) | 3 | PHE A 367ASN A 453PHE A 347 | None | 0.60A | 2zbuD-5a55A:undetectable | 2zbuD-5a55A:13.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cfi | BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE(DIADENOSINETETRAPHOSPHATASE),PUTATIVE (Plasmodiumfalciparum) |
PF00293(NUDIX) | 3 | PHE A 30ASN A 28PHE A 32 | None | 1.02A | 2zbuD-5cfiA:undetectable | 2zbuD-5cfiA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d8g | TRYPTOPHANASE (Escherichiacoli) |
PF01212(Beta_elim_lyase) | 3 | PHE A 39ASN A 37PHE A 399 | None | 1.09A | 2zbuD-5d8gA:undetectable | 2zbuD-5d8gA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h5z | MHC CLASS I ANTIGEN (Ctenopharyngodonidella) |
no annotation | 3 | PHE A 120ASN A 134PHE A 84 | None | 1.09A | 2zbuD-5h5zA:undetectable | 2zbuD-5h5zA:15.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ig2 | SHORT-CHAINDEHYDROGENASE/REDUCTASE SDR (Paraburkholderiaphymatum) |
PF00106(adh_short) | 3 | PHE A 18ASN A 90PHE A 22 | NAD A 301 (-4.1A)NAD A 301 (-3.3A)None | 1.06A | 2zbuD-5ig2A:2.8 | 2zbuD-5ig2A:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iob | BETA-GLUCOSIDASE-RELATED GLYCOSIDASES (Corynebacteriumglutamicum) |
PF00933(Glyco_hydro_3) | 3 | PHE A 133ASN A 182PHE A 216 | None | 1.04A | 2zbuD-5iobA:undetectable | 2zbuD-5iobA:24.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jzb | 4,5:9,10-DISECO-3-HYDROXY-5,9,17-TRIOXOANDROSTA-1(10),2-DIENE-4-OATE HYDROLASE (Mycobacteriumtuberculosis) |
PF12697(Abhydrolase_6) | 3 | PHE A 55ASN A 58PHE A 279 | None | 1.04A | 2zbuD-5jzbA:2.8 | 2zbuD-5jzbA:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lmz | FLUORINASE (Streptomycessp. MA37) |
PF01887(SAM_adeno_trans) | 3 | PHE A 213ASN A 215PHE A 254 | 1DA A 301 (-3.0A)1DA A 301 (-2.0A)1DA A 301 (-3.3A) | 0.25A | 2zbuD-5lmzA:30.3 | 2zbuD-5lmzA:29.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n4l | CERULOPLASMIN (Rattusnorvegicus) |
no annotation | 3 | PHE A 742ASN A 740PHE A 941 | None | 0.84A | 2zbuD-5n4lA:undetectable | 2zbuD-5n4lA:17.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o00 | GLUTATHIONETRANSFERASE URE2P5 (Phanerochaetechrysosporium) |
PF00043(GST_C)PF02798(GST_N) | 3 | PHE A 173ASN A 177PHE A 117 | None | 0.80A | 2zbuD-5o00A:undetectable | 2zbuD-5o00A:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t77 | PUTATIVE LIPID IIFLIPPASE MURJ (Thermosiphoafricanus) |
PF03023(MVIN) | 3 | PHE A 457ASN A 423PHE A 461 | None | 0.93A | 2zbuD-5t77A:undetectable | 2zbuD-5t77A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uja | BOVINE MULTIDRUGRESISTANCE PROTEIN 1(MRP1),MULTIDRUGRESISTANCE-ASSOCIATED PROTEIN 1 (Bos taurus) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 3 | PHE A 329ASN A 442PHE A 325 | None | 1.07A | 2zbuD-5ujaA:undetectable | 2zbuD-5ujaA:11.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w2m | DNA DC->DU-EDITINGENZYME APOBEC-3F (Homo sapiens) |
no annotation | 3 | PHE A 361ASN A 206PHE A 336 | None | 1.07A | 2zbuD-5w2mA:undetectable | 2zbuD-5w2mA:12.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xap | PROTEIN TRANSLOCASESUBUNIT SECD (Deinococcusradiodurans) |
PF02355(SecD_SecF)PF07549(Sec_GG) | 3 | PHE A 468ASN A 695PHE A 470 | OLC A 803 (-3.9A)NoneOLC A 803 ( 4.2A) | 1.01A | 2zbuD-5xapA:undetectable | 2zbuD-5xapA:16.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6acd | - (-) |
no annotation | 3 | PHE A 22ASN A 135PHE A 76 | None | 0.93A | 2zbuD-6acdA:undetectable | 2zbuD-6acdA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6acd | - (-) |
no annotation | 3 | PHE A 529ASN A 530PHE A 551 | None | 1.03A | 2zbuD-6acdA:undetectable | 2zbuD-6acdA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cza | - (-) |
no annotation | 3 | PHE A 802ASN A 827PHE A 843 | MGD A 903 (-3.7A)MGD A 903 (-2.2A)MGD A 903 (-4.2A) | 0.97A | 2zbuD-6czaA:undetectable | 2zbuD-6czaA:undetectable |