SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZBU_C_ADNC503_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE

(Streptomyces
cattleya) 		PF01887
(SAM_adeno_trans) 		4 PHE A 213
ASN A 215
PHE A 254
ASN A 278
 None
 0.41A 2zbuC-2c4tA:
30.7		 2zbuC-2c4tA:
28.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q6k CHLORINASE

(Salinispora
tropica) 		PF01887
(SAM_adeno_trans) 		4 PHE A 186
ASN A 188
PHE A 228
ASN A 251
 None
 0.16A 2zbuC-2q6kA:
31.6		 2zbuC-2q6kA:
32.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zbv UNCHARACTERIZED
CONSERVED PROTEIN

(Thermotoga
maritima) 		PF01887
(SAM_adeno_trans) 		4 PHE A 180
ASN A 182
PHE A 220
ASN A 243
 None
 0.10A 2zbuC-2zbvA:
42.9		 2zbuC-2zbvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ets 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE

(Staphylococcus
aureus) 		no annotation 4 PHE B 123
ASN B  56
PHE B  54
ASN B  53
 5RX  B 202 (-3.3A)
5RX  B 202 (-3.2A)
5RX  B 202 (-3.4A)
None
 1.39A 2zbuC-5etsB:
0.0		 2zbuC-5etsB:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmz FLUORINASE

(Streptomyces
sp. MA37) 		PF01887
(SAM_adeno_trans) 		4 PHE A 213
ASN A 215
PHE A 254
ASN A 278
 1DA  A 301 (-3.0A)
1DA  A 301 (-2.0A)
1DA  A 301 (-3.3A)
1DA  A 301 ( 4.4A)
 0.28A 2zbuC-5lmzA:
30.4		 2zbuC-5lmzA:
29.17