SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZBU_B_ADNB502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zbv UNCHARACTERIZED
CONSERVED PROTEIN

(Thermotoga
maritima) 		PF01887
(SAM_adeno_trans) 		5 ASP A   7
TRP A   8
PHE A  41
TYR A  69
VAL A  71
 ADN  A 501 (-3.0A)
ADN  A 501 (-4.6A)
ADN  A 501 (-4.3A)
None
ADN  A 501 ( 4.5A)
 0.19A 2zbuB-2zbvA:
41.8		 2zbuB-2zbvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 ASP A 480
TRP A 599
TYR A 484
VAL A 486
 None
 1.41A 2zbuB-3a24A:
0.0		 2zbuB-3a24A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7x FEMALE-SPECIFIC
HISTAMINE-BINDING
PROTEIN 2

(Rhipicephalus
appendiculatus) 		PF02098
(His_binding) 		4 TRP A 137
PHE A 152
TYR A 134
VAL A 124
 None
None
None
HSM  A 174 (-4.4A)
 1.33A 2zbuB-3g7xA:
0.4		 2zbuB-3g7xA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		4 ASP W 136
PHE W 154
TYR W 156
VAL W 164
 None
 1.27A 2zbuB-3iylW:
1.0		 2zbuB-3iylW:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pin PEPTIDE METHIONINE
SULFOXIDE REDUCTASE

(Saccharomyces
cerevisiae) 		PF01625
(PMSR) 		4 ASP B  73
PHE B  74
TYR B  48
VAL B  77
 None
 1.21A 2zbuB-3pinB:
0.0		 2zbuB-3pinB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cj0 ENDOGLUCANASE D

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 ASP A 399
TRP A 560
PHE A 398
VAL A 464
 GOL  A1583 (-3.6A)
None
None
None
 1.47A 2zbuB-4cj0A:
0.0		 2zbuB-4cj0A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il3 STE24P

(Saccharomyces
mikatae) 		PF01435
(Peptidase_M48)
PF16491
(Peptidase_M48_N) 		4 ASP A 193
TRP A 196
PHE A 190
VAL A 200
 None
 1.17A 2zbuB-4il3A:
2.0		 2zbuB-4il3A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9g 2,4'-DIHYDROXYACETOP
HENONE DIOXYGENASE

(Alcaligenes sp.) 		PF07883
(Cupin_2) 		4 ASP A  63
TRP A  61
PHE A 128
VAL A  82
 GOL  A 403 (-3.1A)
GOL  A 403 (-4.4A)
None
None
 1.19A 2zbuB-4p9gA:
0.0		 2zbuB-4p9gA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpx 2,4'-DIHYDROXYACETOP
HENONE DIOXYGENASE

(Alcaligenes sp.) 		PF07883
(Cupin_2) 		4 ASP A  63
TRP A  61
PHE A 128
VAL A  82
 GOL  A 203 (-3.0A)
GOL  A 203 (-4.3A)
None
None
 1.23A 2zbuB-5bpxA:
0.0		 2zbuB-5bpxA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgc ANTI-HCV E2 FAB
HC33.8 HEAVY CHAIN
ANTI-HCV E2 FAB
HC33.8 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TRP B  90
PHE E 114
TYR E 113
VAL E 101
 None
 1.40A 2zbuB-5fgcB:
undetectable		 2zbuB-5fgcB:
21.28