SIMILAR PATTERNS OF AMINO ACIDS FOR 2ZBP_A_SAMA300

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhy P64K

(Neisseria
meningitidis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 129
GLY A 134
LEU A 157
ILE A 270
LEU A 241
 FAD  A 600 (-3.0A)
None
None
None
None
 0.86A 2zbpA-1bhyA:
3.4		 2zbpA-1bhyA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)

(Geobacillus
stearothermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 GLY A  88
LEU A 361
GLY A 377
GLY A 248
SER A 399
 CA  A3001 (-3.4A)
None
None
None
None
 1.09A 2zbpA-1brwA:
undetectable		 2zbpA-1brwA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqj SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 GLY A 176
GLY A 184
GLY A 120
ILE A 182
ASP A 180
 None
 1.11A 2zbpA-1cqjA:
6.7		 2zbpA-1cqjA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d3b PROTEIN (SMALL
NUCLEAR
RIBONUCLEOPROTEIN SM
D3)
PROTEIN (SMALL
NUCLEAR
RIBONUCLEOPROTEIN
ASSOCIATED PROTEIN
B)

(Homo sapiens;
Homo sapiens) 		PF01423
(LSM)
PF01423
(LSM) 		5 GLY A  65
LEU B  77
GLY B  74
LEU B  72
LEU B  42
 None
CIT  B 702 (-4.4A)
None
None
None
 1.10A 2zbpA-1d3bA:
undetectable		 2zbpA-1d3bA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dus MJ0882

(Methanocaldococcus
jannaschii) 		PF05175
(MTS) 		5 PHE A  35
GLY A  63
GLY A  65
ILE A  85
ASN A 129
 None
 0.72A 2zbpA-1dusA:
18.5		 2zbpA-1dusA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dus MJ0882

(Methanocaldococcus
jannaschii) 		PF05175
(MTS) 		5 PHE A  35
LEU A  62
GLY A  63
GLY A  65
ASN A 129
 None
 0.47A 2zbpA-1dusA:
18.5		 2zbpA-1dusA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE

(Methanothermobacter
thermautotrophicus) 		PF00296
(Bac_luciferase) 		5 LEU A  58
GLY A  59
GLY A  91
ASP A  35
LEU A  80
 None
 1.10A 2zbpA-1f07A:
undetectable		 2zbpA-1f07A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fy2 ASPARTYL DIPEPTIDASE

(Salmonella
enterica) 		PF03575
(Peptidase_S51) 		5 GLY A  88
GLY A 118
GLY A  86
ILE A  83
LEU A 149
 None
 1.03A 2zbpA-1fy2A:
3.3		 2zbpA-1fy2A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE

(Escherichia
virus Lambda) 		PF00149
(Metallophos) 		5 GLY A  99
LEU A 104
ILE A  81
ASN A  57
LEU A  61
 None
 1.12A 2zbpA-1g5bA:
undetectable		 2zbpA-1g5bA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF06087
(Tyr-DNA_phospho) 		5 LEU A 539
GLY A 356
GLY A 371
LEU A 354
LEU A 323
 None
 1.08A 2zbpA-1jy1A:
undetectable		 2zbpA-1jy1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzh PHOSPHOFRUCTOKINASE

(Borreliella
burgdorferi) 		PF00365
(PFK) 		5 GLY A 174
GLY A 145
GLY A  81
LEU A  79
ASP A 382
 SO4  A 601 ( 3.9A)
None
SO4  A 601 ( 3.8A)
None
None
 1.01A 2zbpA-1kzhA:
undetectable		 2zbpA-1kzhA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m93 SERINE PROTEINASE
INHIBITOR 2

(Cowpox virus) 		PF00079
(Serpin) 		5 LEU B 300
GLY B  67
ILE B 128
SER B 298
LEU B 119
 None
 1.02A 2zbpA-1m93B:
undetectable		 2zbpA-1m93B:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8y PROTOONCOPROTEIN

(Rattus
norvegicus) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 GLY C 503
LEU C 434
GLY C 433
GLY C 501
ILE C 429
 None
 1.08A 2zbpA-1n8yC:
undetectable		 2zbpA-1n8yC:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ne2 HYPOTHETICAL PROTEIN
TA1320

(Thermoplasma
acidophilum) 		PF06325
(PrmA) 		6 GLY A  56
GLY A  58
LEU A  62
ILE A  79
ASP A  80
ASN A 114
 None
 0.56A 2zbpA-1ne2A:
17.5		 2zbpA-1ne2A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyr HIGH LEVEL
KASUGAMYCIN
RESISTANCE PROTEIN

(Escherichia
coli) 		PF00398
(RrnaAD) 		5 GLY A  45
GLY A  47
LEU A  51
ASP A  68
ASN A 113
 None
 0.56A 2zbpA-1qyrA:
12.6		 2zbpA-1qyrA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2z HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Saccharomyces
cerevisiae) 		PF08123
(DOT1) 		5 GLY A 399
GLY A 401
ILE A 423
ASN A 479
LEU A 487
 SAH  A 801 (-3.1A)
SAH  A 801 ( 4.2A)
SAH  A 801 (-3.7A)
SAH  A 801 (-4.4A)
SAH  A 801 ( 4.9A)
 0.60A 2zbpA-1u2zA:
9.2		 2zbpA-1u2zA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2z HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Saccharomyces
cerevisiae) 		PF08123
(DOT1) 		5 GLY A 399
LEU A 477
ILE A 423
ASN A 479
LEU A 487
 SAH  A 801 (-3.1A)
None
SAH  A 801 (-3.7A)
SAH  A 801 (-4.4A)
SAH  A 801 ( 4.9A)
 1.03A 2zbpA-1u2zA:
9.2		 2zbpA-1u2zA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy7 HYPOTHETICAL PROTEIN
PH1948

(Pyrococcus
horikoshii) 		PF05175
(MTS) 		5 GLY A  57
GLY A  59
LEU A  63
ASP A  81
ASN A 119
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 ( 4.3A)
None
SAH  A1001 (-4.6A)
 0.49A 2zbpA-1wy7A:
16.5		 2zbpA-1wy7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy7 HYPOTHETICAL PROTEIN
PH1948

(Pyrococcus
horikoshii) 		PF05175
(MTS) 		5 LEU A  56
GLY A  57
GLY A  59
LEU A  63
ASN A 119
 None
SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 ( 4.3A)
SAH  A1001 (-4.6A)
 0.86A 2zbpA-1wy7A:
16.5		 2zbpA-1wy7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt8 THIOSULFATE
SULFURTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00581
(Rhodanese) 		5 PHE A 119
GLY A 120
LEU A 310
LEU A 342
LEU A 325
 None
 0.91A 2zbpA-1yt8A:
undetectable		 2zbpA-1yt8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5o FERREDOXIN--NADP
REDUCTASE

(Synechococcus
sp. PCC 7002) 		PF00175
(NAD_binding_1) 		5 GLY A 361
GLY A 259
ILE A 298
LEU A 288
LEU A 317
 None
 1.06A 2zbpA-2b5oA:
4.3		 2zbpA-2b5oA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		5 GLY A  96
LEU A  87
GLY A  93
LEU A  72
LEU A  43
 None
 1.00A 2zbpA-2bp1A:
undetectable		 2zbpA-2bp1A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzx PUTATIVE TATD
RELATED DNASE

(Staphylococcus
aureus) 		PF01026
(TatD_DNase) 		5 LEU A 123
GLY A  89
LEU A 252
ILE A  60
LEU A 117
 None
 1.07A 2zbpA-2gzxA:
undetectable		 2zbpA-2gzxA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6g PUTATIVE
METHYLTRANSFERASE

(Salmonella
enterica) 		PF03848
(TehB) 		5 LEU A  37
GLY A  38
GLY A  40
LEU A  87
LEU A  90
 None
 0.90A 2zbpA-2i6gA:
15.4		 2zbpA-2i6gA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n0s FE-HYDROGENASE

(Chlamydomonas
reinhardtii) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C) 		5 GLY A 243
GLY A 241
SER A 164
LEU A 424
LEU A 429
 None
 1.01A 2zbpA-2n0sA:
undetectable		 2zbpA-2n0sA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN

(Cyanothece) 		PF00805
(Pentapeptide) 		5 LEU A 107
GLY A 129
LEU A 147
LEU A 112
LEU A  92
 None
 1.10A 2zbpA-2o6wA:
undetectable		 2zbpA-2o6wA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Escherichia
coli) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		5 PHE A 146
GLY A 145
GLY A 289
ILE A 230
LEU A 279
 None
 0.77A 2zbpA-2o7pA:
undetectable		 2zbpA-2o7pA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oby PUTATIVE QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 218
ILE A 246
ASP A 245
LEU A 237
LEU A 261
 None
 0.92A 2zbpA-2obyA:
10.7		 2zbpA-2obyA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1z ANTI-SIGMA FACTOR
CHRR,
TRANSCRIPTIONAL
ACTIVATOR CHRR

(Rhodobacter
sphaeroides) 		PF12973
(Cupin_7)
PF13490
(zf-HC2) 		5 PHE B 163
LEU B  34
GLY B 166
GLY B 164
LEU B 150
 None
 1.07A 2zbpA-2q1zB:
undetectable		 2zbpA-2q1zB:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf8 EXCINUCLEASE ABC
SUBUNIT A

(Deinococcus
radiodurans) 		PF00005
(ABC_tran) 		5 GLY A 535
GLY A 533
ASN A 511
LEU A 513
LEU A 516
 ADP  A1844 (-3.2A)
ADP  A1844 (-3.3A)
ADP  A1844 (-3.6A)
None
None
 0.98A 2zbpA-2vf8A:
undetectable		 2zbpA-2vf8A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Thermus
thermophilus) 		PF14589
(NrfD_2) 		5 GLY C 103
GLY C  97
GLY C  99
LEU C  61
LEU C  64
 None
None
None
None
MQ7  C1252 (-3.5A)
 0.98A 2zbpA-2vpwC:
undetectable		 2zbpA-2vpwC:
28.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy0 ANGIOTENSINOGEN

(Mus musculus) 		PF00079
(Serpin) 		5 GLY C  97
GLY C  94
ILE C  99
ASN C 448
LEU C 351
 None
 0.98A 2zbpA-2wy0C:
undetectable		 2zbpA-2wy0C:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 GLY A 599
GLY A 596
ASP A 644
LEU A 623
LEU A 627
 None
 1.10A 2zbpA-2xf2A:
undetectable		 2zbpA-2xf2A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xva TELLURITE RESISTANCE
PROTEIN TEHB

(Escherichia
coli) 		PF03848
(TehB) 		5 LEU A  37
GLY A  38
GLY A  40
LEU A  87
LEU A  90
 None
SFG  A1198 (-4.3A)
SFG  A1198 (-3.2A)
SFG  A1198 (-3.8A)
None
 0.81A 2zbpA-2xvaA:
14.2		 2zbpA-2xvaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA

(Methanocaldococcus
jannaschii) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 GLY A 182
GLY A 190
GLY A 126
ILE A 188
ASP A 186
 None
 1.02A 2zbpA-2yv1A:
7.0		 2zbpA-2yv1A:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Aeropyrum
pernix) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 GLY A 183
GLY A 191
GLY A 127
ILE A 189
ASP A 187
 None
 1.08A 2zbpA-2yv2A:
7.4		 2zbpA-2yv2A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		6 PHE A 207
GLY A 241
GLY A 243
LEU A 247
ASP A 264
ASN A 305
 SAH  A 376 (-3.4A)
SAH  A 376 (-3.1A)
SAH  A 376 (-3.4A)
SAH  A 376 ( 4.4A)
None
SAH  A 376 (-4.4A)
 0.57A 2zbpA-2zwvA:
17.9		 2zbpA-2zwvA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		6 PHE A 207
LEU A 240
GLY A 241
GLY A 243
LEU A 247
ASN A 305
 SAH  A 376 (-3.4A)
None
SAH  A 376 (-3.1A)
SAH  A 376 (-3.4A)
SAH  A 376 ( 4.4A)
SAH  A 376 (-4.4A)
 0.63A 2zbpA-2zwvA:
17.9		 2zbpA-2zwvA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 GLY A 187
GLY A 217
ILE A 268
LEU A 288
LEU A 287
 None
 1.10A 2zbpA-2zxoA:
undetectable		 2zbpA-2zxoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp. A1) 		no annotation 5 GLY C 336
GLY C 326
LEU C 294
LEU C 340
LEU C 357
 None
 1.09A 2zbpA-3amjC:
undetectable		 2zbpA-3amjC:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anx SPERMIDINE SYNTHASE

(Thermus
thermophilus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		6 GLY A  85
GLY A  87
ILE A 109
ASP A 110
LEU A 159
LEU A 172
 MTA  A 315 (-3.2A)
MTA  A 315 (-4.0A)
MTA  A 315 (-3.7A)
None
None
MTA  A 315 (-4.3A)
 0.96A 2zbpA-3anxA:
11.7		 2zbpA-3anxA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 314
LEU A 132
GLY A 135
LEU A 127
LEU A  98
 None
 0.93A 2zbpA-3bjsA:
undetectable		 2zbpA-3bjsA:
21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3cjt RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF06325
(PrmA) 		12 PHE A  99
GLY A 100
LEU A 127
GLY A 128
GLY A 130
LEU A 134
ILE A 150
ASP A 151
SER A 175
ASN A 191
LEU A 192
LEU A 196
 SAH  A 258 ( 4.3A)
SAH  A 258 (-3.1A)
None
SAH  A 258 (-3.1A)
SAH  A 258 (-3.6A)
SAH  A 258 (-4.2A)
SAH  A 258 (-4.0A)
None
SAH  A 258 (-2.6A)
SAH  A 258 ( 3.8A)
None
SAH  A 258 (-4.6A)
 0.31A 2zbpA-3cjtA:
37.1		 2zbpA-3cjtA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7d COBH, PRECORRIN-8X
METHYLMUTASE

(Brucella
abortus) 		PF02570
(CbiC) 		5 GLY A 191
LEU A 174
GLY A 159
LEU A 140
LEU A 143
 None
 1.05A 2zbpA-3e7dA:
undetectable		 2zbpA-3e7dA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE

(Pseudomonas
putida) 		PF13489
(Methyltransf_23) 		5 LEU A  58
GLY A  59
GLY A  61
LEU A  65
ASN A 122
 None
SAH  A 300 (-4.2A)
SAH  A 300 (-3.1A)
None
SAH  A 300 (-3.8A)
 0.89A 2zbpA-3e8sA:
14.4		 2zbpA-3e8sA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8u TAPASIN

(Homo sapiens) 		PF07654
(C1-set) 		5 LEU B  55
LEU B 118
ILE B   5
LEU B 115
LEU B 113
 None
 1.00A 2zbpA-3f8uB:
undetectable		 2zbpA-3f8uB:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		5 GLY A  38
GLY A  40
ILE A  60
ASP A  61
ASN A 101
 None
 0.71A 2zbpA-3fydA:
14.0		 2zbpA-3fydA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		5 GLY A  38
GLY A  40
LEU A  44
ILE A  60
ASP A  61
 None
 0.84A 2zbpA-3fydA:
14.0		 2zbpA-3fydA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gry DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		6 GLY A  38
GLY A  40
LEU A  44
ILE A  60
ASP A  61
ASN A 101
 SAM  A 300 (-3.3A)
SAM  A 300 (-3.3A)
SAM  A 300 ( 4.7A)
SAM  A 300 (-3.9A)
None
SAM  A 300 (-3.6A)
 0.87A 2zbpA-3gryA:
13.5		 2zbpA-3gryA:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3grz RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE

(Lactobacillus
delbrueckii) 		PF06325
(PrmA) 		5 GLY A 184
GLY A 186
LEU A 190
ILE A 207
ASN A 248
 GOL  A 322 ( 3.7A)
None
None
GOL  A 322 (-4.1A)
None
 0.60A 2zbpA-3grzA:
26.2		 2zbpA-3grzA:
30.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpf MUCONATE
CYCLOISOMERASE

(Oceanobacillus
iheyensis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A  36
GLY A  99
GLY A  38
LEU A 104
LEU A  56
 None
 0.95A 2zbpA-3hpfA:
undetectable		 2zbpA-3hpfA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE

(Pimelobacter
simplex) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 GLY A 663
LEU A 395
GLY A 403
LEU A 410
LEU A 632
 None
 0.83A 2zbpA-3k30A:
5.3		 2zbpA-3k30A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k94 THIAMIN
PYROPHOSPHOKINASE

(Geobacillus
thermodenitrificans) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		5 GLY A 104
LEU A  98
GLY A   9
ASP A  31
LEU A 115
 None
 1.02A 2zbpA-3k94A:
undetectable		 2zbpA-3k94A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lga SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
abyssi) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		5 GLY A 101
GLY A 103
LEU A 107
ILE A 126
LEU A 170
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.3A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.2A)
 0.75A 2zbpA-3lgaA:
17.6		 2zbpA-3lgaA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Novosphingobium
aromaticivorans) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 LEU A 165
GLY A 164
GLY A 246
LEU A 180
LEU A 211
 None
 1.08A 2zbpA-3lxdA:
undetectable		 2zbpA-3lxdA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkq COATOMER
BETA'-SUBUNIT

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF04053
(Coatomer_WDAD) 		5 PHE A 295
GLY A 294
GLY A  18
GLY A 290
LEU A  32
 None
 1.06A 2zbpA-3mkqA:
undetectable		 2zbpA-3mkqA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n01 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE-LIKE N

(Homo sapiens) 		PF11548
(Receptor_IA-2) 		5 GLY A 555
GLY A 553
LEU A 527
ILE A 549
LEU A 514
 None
 1.11A 2zbpA-3n01A:
3.4		 2zbpA-3n01A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzg PUTATIVE RACEMASE

(Pseudovibrio
sp. JE062) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 293
LEU A  45
GLY A  46
GLY A 109
LEU A 354
 None
 0.91A 2zbpA-3nzgA:
undetectable		 2zbpA-3nzgA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om8 PROBABLE HYDROLASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		5 GLY A 105
GLY A  97
LEU A 100
ILE A 116
LEU A  82
 None
None
EDO  A 266 (-3.7A)
None
None
 1.10A 2zbpA-3om8A:
2.5		 2zbpA-3om8A:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE

(Thermoplasma
acidophilum) 		PF01494
(FAD_binding_3) 		5 GLY A 223
GLY A 208
GLY A 225
LEU A 201
LEU A 357
 None
OZ2  A 502 ( 3.9A)
OZ2  A 502 ( 4.0A)
None
None
 1.11A 2zbpA-3oz2A:
undetectable		 2zbpA-3oz2A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp8 GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE A

(Salmonella
enterica) 		PF02826
(2-Hacid_dh_C) 		5 GLY A 304
LEU A  43
ILE A 286
ASP A 287
LEU A  63
 None
 1.11A 2zbpA-3pp8A:
4.7		 2zbpA-3pp8A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqi GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Coxiella
burnetii) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 LEU A 246
GLY A 332
SER A 217
LEU A 375
LEU A 378
 None
 1.10A 2zbpA-3tqiA:
3.3		 2zbpA-3tqiA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 PHE A   9
GLY A   8
GLY A  11
GLY A 366
LEU A  66
 None
 0.95A 2zbpA-3w15A:
undetectable		 2zbpA-3w15A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 LEU A 195
GLY A 532
ASN A 399
LEU A 398
LEU A 389
 None
 1.09A 2zbpA-4b56A:
undetectable		 2zbpA-4b56A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Mus musculus) 		PF06325
(PrmA) 		5 GLY A  72
GLY A  74
LEU A  78
SER A 123
LEU A 145
 SAH  A1689 (-3.0A)
SAH  A1689 ( 3.7A)
SAH  A1689 (-4.5A)
SAH  A1689 (-3.0A)
SAH  A1689 (-4.4A)
 0.49A 2zbpA-4c4aA:
9.5		 2zbpA-4c4aA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli) 		PF05175
(MTS) 		5 PHE A 208
LEU A 235
GLY A 236
GLY A 238
ASN A 305
 SAM  A 401 (-3.6A)
None
SAM  A 401 (-3.5A)
SAM  A 401 ( 3.7A)
SAM  A 401 (-3.8A)
 0.38A 2zbpA-4dcmA:
13.6		 2zbpA-4dcmA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6e CELL DIVISION
PROTEIN FTSZ

(Thermobifida
fusca) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A  65
LEU A  56
GLY A  59
ASP A  81
ASN A  41
 None
None
None
None
SO4  A 607 ( 4.3A)
 0.80A 2zbpA-4e6eA:
2.3		 2zbpA-4e6eA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqf PEX5-RELATED PROTEIN

(Mus musculus) 		PF13181
(TPR_8)
PF13432
(TPR_16) 		5 PHE A 183
GLY A 181
GLY A 174
LEU A 179
ASP A 188
 None
 0.96A 2zbpA-4eqfA:
undetectable		 2zbpA-4eqfA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL

(Mus musculus) 		PF00398
(RrnaAD) 		5 GLY A  63
GLY A  65
ASP A  87
ASN A 141
LEU A 142
 ACT  A 402 (-3.4A)
None
None
None
None
 0.50A 2zbpA-4gc5A:
12.8		 2zbpA-4gc5A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h41 PUTATIVE
ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF14488
(DUF4434)
PF17134
(DUF5109) 		5 GLY A 184
LEU A 132
ILE A  94
ASP A  95
LEU A  65
 None
 0.96A 2zbpA-4h41A:
undetectable		 2zbpA-4h41A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbz PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE, SIXA

(Nakamurella
multipartita) 		PF00300
(His_Phos_1) 		5 LEU A 148
GLY A 145
GLY A 143
LEU A 175
LEU A 159
 PGE  A 203 ( 4.8A)
None
None
None
None
 0.93A 2zbpA-4hbzA:
undetectable		 2zbpA-4hbzA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k22 PROTEIN VISC

(Escherichia
coli) 		PF01494
(FAD_binding_3) 		5 GLY A  15
GLY A  12
LEU A 117
ASP A 164
LEU A 312
 None
 0.87A 2zbpA-4k22A:
undetectable		 2zbpA-4k22A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN

(Rattus
norvegicus) 		no annotation 5 GLY A 354
LEU A 508
ILE A 360
ASP A 359
SER A 490
 None
 1.03A 2zbpA-4lc9A:
undetectable		 2zbpA-4lc9A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhs UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF14606
(Lipase_GDSL_3)
PF14607
(GxDLY) 		5 GLY A 198
GLY A 191
SER A 219
LEU A 101
LEU A  98
 None
None
PEG  A 400 ( 4.3A)
None
None
 0.86A 2zbpA-4lhsA:
undetectable		 2zbpA-4lhsA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nrh COPN

(Chlamydia
pneumoniae) 		PF07201
(HrpJ) 		5 LEU A 115
GLY A 120
ASP A 127
LEU A 149
LEU A 146
 None
 0.99A 2zbpA-4nrhA:
undetectable		 2zbpA-4nrhA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqr CYP105AS1

(Amycolatopsis
orientalis) 		PF00067
(p450) 		5 GLY A 391
LEU A 256
GLY A 252
GLY A 250
LEU A 275
 None
 1.08A 2zbpA-4oqrA:
undetectable		 2zbpA-4oqrA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqs CYP105AS1

(Amycolatopsis
orientalis) 		PF00067
(p450) 		5 GLY A 391
LEU A 256
GLY A 252
GLY A 250
LEU A 275
 None
 1.07A 2zbpA-4oqsA:
undetectable		 2zbpA-4oqsA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		5 GLY A1044
LEU A1555
GLY A1554
ILE A1604
ASP A1605
 None
 1.02A 2zbpA-4r04A:
undetectable		 2zbpA-4r04A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		5 GLY A 262
LEU A 226
ILE A 186
LEU A 224
LEU A 200
 None
 0.94A 2zbpA-4u7lA:
undetectable		 2zbpA-4u7lA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yei BETA1MUT

(synthetic
construct) 		PF00805
(Pentapeptide) 		5 LEU A  67
GLY A  89
LEU A 107
LEU A  72
LEU A  52
 None
 1.12A 2zbpA-4yeiA:
undetectable		 2zbpA-4yeiA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Brucella ovis) 		PF00497
(SBP_bac_3) 		5 GLY A 183
LEU A 188
ILE A 293
SER A 179
LEU A  22
 None
None
None
None
GSH  A 401 ( 4.7A)
 1.08A 2zbpA-4z9nA:
undetectable		 2zbpA-4z9nA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ca5 NONO-1

(Caenorhabditis
elegans) 		PF00076
(RRM_1)
PF08075
(NOPS) 		5 GLY A 151
LEU A 118
GLY A 121
ILE A 170
LEU A 155
 None
 1.03A 2zbpA-5ca5A:
3.5		 2zbpA-5ca5A:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqr 7-HYDROXYMETHYL
CHLOROPHYLL A
REDUCTASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04422
(FrhB_FdhB_N)
PF04432
(FrhB_FdhB_C) 		5 PHE A 247
LEU A 186
GLY A 239
GLY A 243
ASP A 293
 None
 1.08A 2zbpA-5dqrA:
undetectable		 2zbpA-5dqrA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqs ELONGATION FACTOR
1-GAMMA

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 LEU A 139
LEU A 146
ASP A 105
LEU A 168
LEU A 171
 None
 1.11A 2zbpA-5dqsA:
undetectable		 2zbpA-5dqsA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL

(Homo sapiens) 		PF03630
(Fumble) 		5 GLY A 561
GLY A 558
LEU A 336
ILE A 349
LEU A 275
 None
 1.11A 2zbpA-5e26A:
undetectable		 2zbpA-5e26A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 GLY C  53
GLY C 101
GLY C  55
ASP C  40
ASN C  57
 None
 0.99A 2zbpA-5fseC:
undetectable		 2zbpA-5fseC:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5giu PROLINE DIPEPTIDASE

(Deinococcus
radiodurans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 GLY A 316
LEU A 262
ILE A 331
ASP A 329
LEU A 297
 None
 1.01A 2zbpA-5giuA:
undetectable		 2zbpA-5giuA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i51 TRANSKETOLASE

(Scheffersomyces
stipitis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 123
GLY A 119
ILE A 421
LEU A 178
LEU A 175
 None
 1.00A 2zbpA-5i51A:
2.2		 2zbpA-5i51A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum) 		PF00920
(ILVD_EDD) 		5 GLY A 204
GLY A 275
ILE A 267
ASN A 278
LEU A 284
 None
None
None
KCX  A 129 ( 3.9A)
None
 0.88A 2zbpA-5j84A:
undetectable		 2zbpA-5j84A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jho ELECTRONEUTRAL
SODIUM BICARBONATE
EXCHANGER 1

(Homo sapiens) 		PF07565
(Band_3_cyto) 		5 GLY A  51
ILE A 310
ASP A 313
LEU A 329
LEU A 120
 None
 0.90A 2zbpA-5jhoA:
undetectable		 2zbpA-5jhoA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m45 ACETONE CARBOXYLASE
BETA SUBUNIT

(Xanthobacter
autotrophicus) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		5 LEU B  14
GLY B  75
ASP B 260
LEU B  72
LEU B  69
 None
 1.10A 2zbpA-5m45B:
undetectable		 2zbpA-5m45B:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m7r PROTEIN O-GLCNACASE

(Homo sapiens) 		PF07555
(NAGidase) 		5 LEU A 628
ILE A 636
ASP A 639
LEU A 561
LEU A 558
 None
 1.10A 2zbpA-5m7rA:
undetectable		 2zbpA-5m7rA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nit GLUCOSE OXIDASE

(Aspergillus
niger) 		no annotation 5 GLY A 304
GLY A 302
ILE A 308
SER A 307
LEU A 324
 None
 1.06A 2zbpA-5nitA:
undetectable		 2zbpA-5nitA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		no annotation 5 GLY C 502
LEU C 433
GLY C 432
GLY C 500
ILE C 428
 None
 1.02A 2zbpA-5o4gC:
undetectable		 2zbpA-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u25 DIHYDROLIPOAMIDE
DEHYDROGENASE (E3
COMPONENT OF
PYRUVATE AND
2-OXOGLUTARATE
DEHYDROGENASE
COMPLEXES)

(Neisseria
gonorrhoeae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 124
GLY A 129
LEU A 152
ILE A 265
LEU A 236
 FAD  A 601 (-3.3A)
None
None
None
None
 0.88A 2zbpA-5u25A:
undetectable		 2zbpA-5u25A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9r CITRATE-SODIUM
SYMPORTER

(Klebsiella
pneumoniae) 		PF03390
(2HCT) 		5 GLY A 403
GLY A 189
GLY A 184
LEU A 216
ASN A 186
 FLC  A 501 ( 3.8A)
None
None
None
FLC  A 501 (-3.7A)
 1.07A 2zbpA-5x9rA:
undetectable		 2zbpA-5x9rA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysm CYTOCHROME P450

(Amycolatopsis
mediterranei) 		no annotation 5 GLY A 409
LEU A 272
GLY A 268
GLY A 266
LEU A 296
 None
 1.09A 2zbpA-5ysmA:
undetectable		 2zbpA-5ysmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq6 THERMOSPERMINE
SYNTHASE

(Medicago
truncatula) 		no annotation 5 GLY A 108
ILE A 130
ASP A 131
LEU A 179
LEU A 191
 CL  A 401 (-4.6A)
None
None
None
None
 1.11A 2zbpA-6bq6A:
11.9		 2zbpA-6bq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ej2 BETA-SECRETASE 1

(Homo sapiens) 		no annotation 5 GLY A 743
GLY A 422
LEU A 563
ILE A 519
LEU A 439
 None
B7E  A 901 (-3.8A)
None
None
B7E  A 901 (-4.6A)
 1.07A 2zbpA-6ej2A:
undetectable		 2zbpA-6ej2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsh OXYB PROTEIN

(Actinoplanes
teichomyceticus) 		no annotation 5 GLY A 390
LEU A 252
GLY A 248
GLY A 246
LEU A 276
 None
 1.01A 2zbpA-6fshA:
undetectable		 2zbpA-6fshA:
undetectable